An electric field input method for a sweat-promoting device worn by a human body

Abstract

The application discloses a detection technology field of human sweat, and particularly relates to an electric field input method of a sweat promoting device for human wearing, which comprises the following operation steps: S1: two low-voltage pulses are generated to rapidly form electrically induced pores on the surface of the skin, wherein the first pulse voltage is 2-10 V, the pulse time is 300-600 ms, then, on the basis of the pulse, a second pulse voltage of 15-35 V is output, the pulse time is 10-30 ms, and the pulse is an exponential decay type pulse; S2: the first pulse voltage is obviously lower than the second pulse voltage, after starting to work, the circuit outputs a certain voltage, the size of the skin resistance is analyzed according to the formed current, and the first pulse voltage and the second pulse voltage are adjusted according to the skin resistance, the method is safe and fast, can generate temporary permeable pores in a short time, thereby rapidly improving the permeability of sweat promoting drugs, accelerating the speed of sweat gland perspiration, and greatly improving the experience of users during use.

Description

Technical Field

[0001] This invention relates to the field of human sweat detection technology, specifically to an electric field input method for a sweat-inducing device worn on the human body. Background Technology

[0002] In recent years, the detection of human sweat has become a non-invasive and efficient medical auxiliary detection method, with the detection range including blood sugar, lactic acid, and uric acid. However, for many middle-aged and elderly people, it is difficult to first engage in a lot of exercise to sweat and then collect sweat for testing. Therefore, how to induce sweating in the human body without exercise or even while sitting has become an important issue in sweat detection. This invention applies to a sweat-inducing device, which is similar to a wristband and can be worn directly on the arm. It generates a continuous weak current to deliver specific drugs into the sweat glands of the skin, thereby inducing the sweat glands to actively sweat. This process belongs to a transdermal drug delivery system.

[0003] Transdermal drug delivery systems are novel dosage forms that deliver drugs to the skin surface at a constant (or near-constant) rate, allowing the drug to enter the systemic circulation and produce systemic or local therapeutic effects. However, drug penetration through the skin requires overcoming the barrier of the epidermis, especially the stratum corneum. Therefore, electroporation technology is commonly used in transdermal drug delivery systems to improve drug penetration efficiency. Common electroporation techniques use a series of high-voltage electric pulses applied to the skin to alter the orientation of lipid molecules in the stratum corneum, creating temporary permeable pores on the skin surface. Drugs then rapidly penetrate these pores, achieving fast and effective drug penetration. When the pulsed electric field ends, these pores close, and skin permeability is reversibly restored.

[0004] During transdermal drug delivery to promote sweat excretion, obstacles from the stratum corneum of the epidermis are encountered. Overcoming these obstacles and enabling the excretion-promoting drugs to quickly penetrate into the sweat glands is the key to achieving efficient sweat excretion promotion. If traditional electroporation technology is used to overcome these obstacles, a series of continuous high-voltage electrical pulses (100-300V) are required, which will affect the user's wearing experience. In addition, due to the need for continuous high-voltage pulse output, the size of the high-voltage output unit of the excretion-promoting device is increased, which is not conducive to the miniaturization design of the overall structure.

[0005] Therefore, we propose an electric field input method for a sweat-inducing device worn on the human body. Summary of the Invention

[0006] In view of the problems existing in the above and / or existing electric field input methods of sweat-inducing devices for human wear, the present invention is proposed.

[0007] Therefore, the purpose of this invention is to provide an electric field input method for a sweat-inducing device worn on the human body. By first generating two low-voltage pulses to quickly form electroporation holes on the skin surface, and then outputting a certain voltage through a circuit and analyzing the skin resistance based on the formed current, the voltage magnitudes of the first and second pulses are adjusted accordingly based on the skin resistance, thereby solving the aforementioned existing problems.

[0008] To address the aforementioned technical problems, according to one aspect of the present invention, the present invention provides the following technical solution:

[0009] An electric field input method for a sweat-inducing device worn on the human body, comprising the following steps:

[0010] S1: First, two low-voltage pulses are generated to quickly form electroporation holes on the skin surface. The first pulse voltage is 2-10V and the pulse time is 300-600ms. Then, based on this pulse, the second pulse voltage is 15-35V and the pulse time is 10-30ms. It is an exponentially decaying pulse.

[0011] S2: The first pulse voltage is significantly lower than the second pulse voltage. After the circuit starts working, it outputs a certain voltage and analyzes the skin resistance based on the formed current. The first and second pulse voltages are then adjusted accordingly based on the skin resistance.

[0012] S3: After the second pulse voltage drops to 2-3V, it is maintained for about 300-500ms, and then a DC voltage of 10-35V is continuously output, so that a constant weak current of 1.5-2.5mA is formed on the skin surface, which lasts for about 1-5 minutes to carry out iontophoresis of the drug.

[0013] S4: In the initial stage of iontophoresis, the DC voltage rises in a Bezier curve manner, and the skin surface current rapidly increases to 1.5-2.5 mA;

[0014] S5: As electroporation occurs and iontophoresis continues, the skin resistance decreases as the current reaches the specified output current. At this time, the voltage required to maintain a constant current on the skin surface also decreases. Therefore, the overall trend of DC voltage is to rise rapidly first, then rise slowly, and finally fall slowly.

[0015] In a preferred embodiment of the electric field input method for a sweat-inducing device for human wear described in this invention, the pulse voltage in S1 varies with the surface resistance of human skin; the greater the resistance, the higher the pulse voltage.

[0016] In a preferred embodiment of the electric field input method for a sweat-inducing device for human wear according to the present invention, the adjustment in S2 is to ensure the rapid formation of an effective electroporation aperture.

[0017] In a preferred embodiment of the electric field input method for a sweat-inducing device for human wear described in this invention, the output voltage in step S3 varies with the resistance of human skin; the higher the resistance, the higher the output voltage.

[0018] As a preferred embodiment of the electric field input method for a sweat-inducing device for human wear described in this invention, in step S4, since the voltage rise rate is fast at first and then slows down, it can both quickly increase the current on the skin surface and ensure a smooth and comfortable experience on the skin surface.

[0019] As a preferred embodiment of the electric field input method for a sweat-inducing device for human wear according to the present invention, wherein: the low-voltage pulse in S1 is used to generate a temporary electroporation on the skin surface.

[0020] As a preferred embodiment of the electric field input method for a sweat-inducing device for human wear according to the present invention, wherein: in step S3, subsequent ion introduction generates a low-voltage DC electric field.

[0021] In a preferred embodiment of the electric field input method for a sweat-inducing device for human wear described in this invention, the DC voltage is an ion-importing voltage.

[0022] Compared with existing technologies, the method of this invention is safe and fast, and can generate temporary permeable channels in a short time, thereby quickly improving the permeability of sweat-inducing drugs and accelerating the sweat gland excretion rate. In addition, since the pulse voltage used for electroporation is low and the duration is very short, it greatly improves the user experience. Furthermore, due to its small size, it is conducive to the miniaturization design of the product and makes it convenient for users to wear and use. Attached Figure Description

[0023] Figure 1 The electric field input pulse diagram provided for this invention. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the present invention clearer, the embodiments of the present invention will be described in further detail below with reference to the accompanying drawings.

[0025] This invention provides an electric field input method for a wearable sweat-inducing device. It is safe and quick, and can generate temporary permeable channels in a short time, thereby rapidly improving the permeability of sweat-inducing drugs and accelerating the rate of sweat gland excretion. Please refer to [link to relevant documentation]. Figure 1 The following steps are included:

[0026] S1: First, two low-voltage pulses are generated to quickly form electroporation holes on the skin surface. The first pulse voltage is 2-10V and the pulse duration is 300-600ms. Then, based on this pulse, a second pulse voltage of 15-35V is output with a pulse duration of 10-30ms. It is an exponentially decaying pulse. The pulse voltage changes with the resistance of the human skin surface. The higher the resistance, the higher the pulse voltage.

[0027] S2: The first pulse voltage is significantly lower than the second pulse voltage. After the circuit starts working, it outputs a certain voltage and analyzes the skin resistance based on the formed current. The first and second pulse voltages are adjusted accordingly based on the skin resistance to ensure the rapid formation of an effective electroporation.

[0028] S3: After the second pulse voltage drops to 2-3V, it is maintained for about 300-500ms, and then a DC voltage of 10-35V is continuously output, so that a constant weak current of 1.5-2.5mA is formed on the skin surface, which lasts for about 1-5 minutes to carry out iontophoresis of the drug. The output voltage varies with the resistance of human skin. The higher the resistance, the higher the output voltage.

[0029] S4: In the initial stage of iontophoresis, the DC voltage rises in a Bezier curve manner, and the skin surface current rises rapidly to 1.5-2.5mA. Since the voltage rise rate is fast at first and then slows down, it can both quickly increase the skin surface current and ensure a smooth and comfortable skin surface experience.

[0030] S5: As the electroporation process continues and iontophoresis progresses, the skin resistance decreases as the current reaches the specified output current. At this time, the voltage required to maintain a constant current on the skin surface also decreases. Therefore, the overall trend of DC voltage is to rise rapidly first, then rise slowly, and finally fall slowly.

[0031] The DC voltage is the iontophoresis voltage, which also includes a low-voltage pulse for generating temporary electroporation on the skin surface and a low-voltage DC electric field for subsequent iontophoresis.

[0032] By first generating two low-voltage pulses to quickly form electroporation pores on the skin surface, and then outputting a certain voltage through the circuit and analyzing the skin resistance based on the generated current, the voltage of the first and second pulses is adjusted accordingly. Subsequent DC voltage is then used for iontophoresis of the penetrating drug, achieving a safe and rapid process. This method creates temporary permeable pores in a short time, quickly improving the permeability of sweat-inducing drugs and accelerating sweat gland excretion. Furthermore, because the pulse voltage used for electroporation is low and the duration is short, it greatly improves the user experience. Its small size also facilitates miniaturization and makes the product easier for users to wear.

[0033] Although the present invention has been described above with reference to embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the invention. In particular, as long as there is no structural conflict, the features in the disclosed embodiments can be combined with each other in any manner. The lack of an exhaustive description of these combinations in this specification is merely for the sake of brevity and resource conservation. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A method for inputting an electric field into a sweat-inducing device worn on the human body, characterized in that: The following steps are included: S1: First, a first pulse and a second pulse are generated to form an electroporation hole on the skin surface. The first pulse voltage is 2~10V and the pulse time is 300~600ms. Then, based on this pulse, a second pulse voltage of 15~35V and a pulse time of 10~30ms are output. It is an exponentially decaying pulse. S2: The first pulse voltage is significantly lower than the second pulse voltage. After the circuit starts working, it outputs a certain voltage and analyzes the skin resistance based on the formed current. The first and second pulse voltages are then adjusted accordingly based on the skin resistance. S3: After the second pulse voltage drops to 2~3V, it is maintained for 300~500ms, and then a DC voltage of 10~35V is continuously output, so that a constant weak current of 1.5~2.5mA is formed on the skin surface for 1~5 minutes; S4: In the initial stage of the DC voltage output phase, the DC voltage rises in a Bezier curve manner. S5: During the DC voltage output process, when the current reaches the specified output current, the DC voltage is adjusted according to the change in skin resistance to maintain the constant weak current.

2. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, In S1, the pulse voltage is adjusted according to the surface resistance of human skin; the greater the resistance, the higher the pulse voltage.

3. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, The adjustment in S2 is to ensure the rapid formation of an effective electroporation.

4. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, The magnitude of the DC output voltage in S3 varies with the resistance of human skin; the higher the resistance, the higher the output voltage.

5. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, In S4, the voltage rise rate is initially fast and then slows down.

6. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, The first and second pulses are used to create temporary electroporation on the skin surface.

7. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, The DC voltage is used to generate the low-voltage DC electric field required for iontophoresis on the skin surface.

8. The electric field input method for a sweat-inducing device worn on the human body according to claim 1, characterized in that, The DC voltage is the ion-importing voltage.

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