A medical intermediate vacuum reaction equipment

Abstract

This invention relates to the field of pharmaceutical manufacturing technology, and particularly to a vacuum reaction apparatus for pharmaceutical intermediates, comprising a reaction chamber, a support plate, a pulverizing unit, and a stirring reaction unit. Existing agitators used in pharmaceutical intermediate reaction vessels have the following problems: they cannot pulverize solid particles, thus requiring more time for complete dissolution; because the chamber is connected to the outside, gases or dust in the air can easily enter the chamber through the feed inlet, disrupting the normal reaction of the pharmaceutical intermediates; furthermore, the pharmaceutical intermediates are not heated during the reaction, thus affecting the reaction rate. This invention, however, can pulverize solid particles, thereby accelerating the reaction rate between the solid particles and the solution. In addition, heating the solid particles can accelerate their dissolution, and the reaction chamber is always in a vacuum-sealed state, thereby enhancing the reaction effect between the solid particles and the solution.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical production technology, and in particular to a vacuum reaction apparatus for pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are chemical raw materials or products used in the synthesis of pharmaceuticals. They are usually solid granules. During the production process, the solid granules are typically placed into a special vacuum reaction device and a solution is poured in, allowing the solid granules to react fully with the solution.

[0003] Chinese utility model patent with publication number CN208287996U discloses a stirrer for a pharmaceutical intermediate reaction vessel. The stirrer uses a rotating shaft to drive a horizontal rod, a vertical rod, and a first rotating rod to rotate, thereby stirring the raw materials of the pharmaceutical intermediate. At the same time, the rotating shaft drives a first long rod, a second long rod, a movable horizontal plate, and a movable vertical plate to rotate, making the pharmaceutical intermediate more uniformly stirred.

[0004] However, the above patent has the following problems: 1. Since the pharmaceutical intermediate contains solid particles, and the above patent cannot crush them when stirring the pharmaceutical intermediate, the pharmaceutical intermediate needs more time to completely dissolve during the stirring process.

[0005] 2. Because the feed inlet of the pharmaceutical intermediate cannot be sealed during the stirring process, the chamber is in a state of communication with the outside world. As a result, gases or dust in the air can easily enter the chamber through the feed inlet during the reaction of the pharmaceutical intermediate, which will affect the normal reaction of the pharmaceutical intermediate. In addition, the pharmaceutical intermediate is not heated during the reaction process, which will affect the reaction rate of the pharmaceutical intermediate. Summary of the Invention

[0006] I. Technical problem to be solved: The vacuum reaction equipment for pharmaceutical intermediates provided by the present invention can solve the problems pointed out in the background art above.

[0007] II. Technical Solution: To achieve the above objectives, the present invention adopts the following technical solution: a vacuum reaction device for pharmaceutical intermediates, comprising a reaction cylinder, a support plate, a pulverizing unit, and a stirring reaction unit. The bottom of the reaction cylinder is provided with a discharge port, and the upper end of the reaction cylinder is provided with a through-hole. A one-way valve is installed inside the through-hole. Two support plates are symmetrically arranged at the bottom of the reaction cylinder. The pulverizing unit is installed on the upper side of the reaction cylinder, and the stirring reaction unit is located inside the reaction cylinder.

[0008] The crushing unit includes a feeding cylinder, which is installed at the upper end of the reaction cylinder and extends into the interior of the reaction cylinder at the lower end. A flow-dividing component is installed at the bottom of the feeding cylinder, and a positioning column is provided on the inner bottom wall of the feeding cylinder. An annular frame is rotatably connected to the inner side wall of the feeding cylinder through an annular groove. A crushing cylinder is installed on the inner side wall of the annular frame through a connecting cylinder. The bottom of the crushing cylinder is rotatably connected to the positioning column, and multiple execution columns are evenly installed on the inner wall of the crushing cylinder from top to bottom and circumferentially.

[0009] The stirring reaction unit includes electric heating blocks. Multiple electric heating blocks are detachably installed inside the reaction cylinder and below the feed cylinder. A support plate is installed on the inner wall of the reaction cylinder via circumferentially arranged support rods. A drive motor is installed at the lower end of the support plate via a motor base. A rotating shaft is installed between the output shaft of the drive motor and the lower end of the feed cylinder. The rotating shaft is rotatably connected to the feed cylinder. A linkage plate is sleeved on the outer wall of the rotating shaft and above the support plate. The linkage plate is rotatably connected to the inner wall of the reaction cylinder. Multiple discharge ports are opened on the linkage plate. Multiple conical stirring cylinders are evenly installed circumferentially on the upper part of the linkage plate. Multiple through holes are evenly opened through the side walls of the conical stirring cylinders. Multiple grinding strips are symmetrically arranged on the outer wall of the conical stirring cylinders.

[0010] As a preferred embodiment of the present invention, the diversion assembly includes a discharge cylinder. The bottom of the feed cylinder is uniformly circumferentially mounted with a discharge cylinder connected thereto. On the side of the inner wall of the discharge cylinder away from the feed cylinder, a plurality of fan-shaped plates are uniformly hinged circumferentially by a torsion spring. A sealing strip is provided between adjacent fan-shaped plates. A plurality of fixing blocks corresponding to the positions of the fan-shaped plates are uniformly arranged circumferentially on the inner wall of the discharge cylinder. An installation groove is opened inside the positioning column. An air pump is installed inside the installation groove. A plurality of air outlet pipes extending into the discharge cylinder are uniformly installed circumferentially at the air outlet end of the air pump.

[0011] As a preferred embodiment of the present invention, a plurality of connecting rods are uniformly installed circumferentially on the inner wall of the reaction cylinder above the linkage plate. A first heat-conducting rod that is engaged with the electric heating block is provided inside the connecting rod. A plurality of second heat-conducting rods are installed at equal intervals along the length of the lower end of the first heat-conducting rod, which are staggered with the position of the conical stirring cylinder.

[0012] As a preferred embodiment of the present invention, two triangular plates are symmetrically arranged on the outer wall of the second heat-conducting rod. The upper side of the triangular plates is parallel to the length direction of the first heat-conducting rod, and the side of the triangular plates away from the second heat-conducting rod is parallel to the grinding strip. A material passage hole is opened on the triangular plate, and multiple combing strips are installed at equal intervals from top to bottom inside the material passage hole.

[0013] As a preferred embodiment of the present invention, the top of the positioning column is a tapered structure with a diameter that gradually increases from top to bottom, and the outer wall of the positioning column is uniformly provided with multiple vertical protrusions. A hemispherical crushing block that abuts against the vertical protrusions is installed at one end of the execution column near the positioning column.

[0014] As a preferred embodiment of the present invention, the diameter of the crushing cylinder gradually decreases from top to bottom, a material leakage hole is provided at the bottom of the crushing cylinder, the diameter of the multiple hemispherical crushing blocks on the inner wall of the crushing cylinder gradually decreases from top to bottom, and the distance between the multiple hemispherical crushing blocks and the positioning column gradually decreases from top to bottom.

[0015] As a preferred embodiment of the present invention, the upper end of the support plate is rotatably connected to a rotating pad, the rotating pad is sleeved on the outer wall of the rotating shaft, and a push rod is installed on the upper end of the rotating pad through waterproof cylinders arranged evenly in the circumference. A sealing post corresponding to the position of the discharge port is provided on the top of the push rod.

[0016] As a preferred embodiment of the present invention, the outer wall of the annular frame is fitted with an annular gear ring, and a positioning motor is installed at the upper end of the reaction cylinder and on any side of the feed cylinder. The output shaft of the positioning motor is fitted with a transmission gear that meshes with the annular gear ring.

[0017] III. Beneficial Effects: This invention utilizes a diversion method formed by multiple discharge cylinders, combined with the air pump's blowing action, to accelerate the guidance of pulverized solid particles into the reaction cylinder, thereby saving solid particle filling time. The multi-stage pulverization of solid particles is achieved through the cooperation of multiple hemispherical pulverizing blocks in the pulverizing unit and the vertical protrusions on the outer wall of the positioning column. The grinding strips and triangular plates in the stirring reaction unit further pulverize the solid particles during stirring, resulting in even smaller particles. The sealing performance of the reaction cylinder is ensured through the cooperation of a one-way valve, a closed fan-shaped plate, and a discharge port inserted into the sealing column. The solution inside the reaction cylinder is heated by an electric heating block, a first heat-conducting rod, and a second heat-conducting rod, ensuring comprehensive heating. During this process, the conical stirring cylinder and triangular plates can perform forward and reverse stirring of the solid particles and solution in the reaction cylinder, accelerating the reaction rate and ensuring uniform reaction.

[0018] In summary, this invention can rapidly fill solid particles while simultaneously pulverizing them, and can further pulverize them during stirring, thereby increasing the contact area between the solid particles and the solution and accelerating the reaction rate. In addition, heating can be applied during the stirring of the solid particles and solution to accelerate the dissolution rate of the solid particles, and the reaction chamber is always under vacuum during the reaction process, which enhances the reaction effect between the solid particles and the solution. Attached Figure Description

[0019] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0020] Figure 1This is a three-dimensional structural diagram of the present invention.

[0021] Figure 2 This is a cross-sectional view of the present invention (a longitudinal section along the reaction cylinder and the feed cylinder).

[0022] Figure 3 This is a partial structural schematic diagram of the pulverizing unit of the present invention.

[0023] Figure 4 This is the invention Figure 3 A magnified view of a portion of point S.

[0024] Figure 5 This is a partial cross-sectional view of the reaction cylinder and pulverizing unit of the present invention.

[0025] Figure 6 This is the invention Figure 5 A magnified view of a portion at point F.

[0026] Figure 7 This is a first three-dimensional structural schematic diagram of the reaction cylinder and stirring reaction unit of the present invention.

[0027] Figure 8 This is the invention Figure 7 A magnified view of the Z-axis.

[0028] Figure 9 This is a second three-dimensional structural schematic diagram of the reaction cylinder and stirring reaction unit of the present invention.

[0029] Reference numerals: 1. Reaction cylinder; 11. One-way valve; 2. Support plate; 3. Crushing unit; 31. Feed cylinder; 32. Diverting assembly; 321. Discharge cylinder; 322. Sector plate; 323. Fixing block; 324. Air pump; 325. Air outlet pipe; 33. Positioning column; 331. Vertical protrusion; 34. Annular frame; 341. Annular gear ring; 342. Positioning motor; 343. Transmission gear; 35. Connecting cylinder; 36. Crushing cylinder; 37. Actuating column; 371. Hemispherical crushing block; 4. Stirring reaction unit; 41. Electric heating block; 411. Connecting rod; 412. First heat conducting rod; 413. Second heat conducting rod; 414. Triangular plate; 415. Material passage hole; 416. Combing bar; 42. Support rod; 421. Support plate; 422. Rotating pad; 423. Waterproof cylinder; 424. Push rod; 425. Sealing column; 43. Drive motor; 44. Rotating shaft; 45. Linkage plate; 46. Conical stirring drum. Detailed Implementation

[0030] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings, but the present invention can be implemented in many different ways as defined and covered by the claims.

[0031] See Figure 1 and Figure 2 A vacuum reaction device for pharmaceutical intermediates includes a reaction cylinder 1, a support plate 2, a pulverizing unit 3, and a stirring reaction unit 4. The reaction cylinder 1 has a detachable assembly structure to facilitate the assembly and disassembly of its internal parts. The bottom of the reaction cylinder 1 has a discharge port, and the upper end of the reaction cylinder 1 has a through-hole. A one-way valve 11 is installed inside the through-hole. The one-way valve 11 can only discharge the air in the reaction cylinder 1 and cannot allow external air to enter the reaction cylinder 1. Two support plates 2 are symmetrically arranged at the bottom of the reaction cylinder 1. The pulverizing unit 3 is installed on the upper side of the reaction cylinder 1, and the stirring reaction unit 4 is located inside the reaction cylinder 1.

[0032] See Figure 2 , Figure 3 , Figure 5 and Figure 6 The crushing unit 3 includes a feed cylinder 31, which is installed at the upper end of the reaction cylinder 1. The lower end of the feed cylinder 31 extends into the interior of the reaction cylinder 1. The feed cylinder 31 has a sizing structure for easy assembly and disassembly of its internal components. A diversion assembly 32 is installed at the bottom of the feed cylinder 31. A positioning post 33 is provided on the inner bottom wall of the feed cylinder 31. The top of the positioning post 33 is a tapered structure with a gradually increasing diameter from top to bottom. Multiple vertical protrusions 331 are evenly distributed around the outer wall of the positioning post 33. An annular frame 34 is rotatably connected to the inner side wall of the feed cylinder 31 via an annular groove. An annular toothed ring 341 is fitted on the outer wall of the annular frame 34. A positioning motor 342 is installed at the upper end of the reaction cylinder 1 and on any side of the feed cylinder 31. The output shaft of 342 is fitted with a transmission gear 343 that meshes with the ring gear 341. The inner wall of the ring frame 34 is fitted with a crushing cylinder 36 via a connecting cylinder 35. The bottom of the crushing cylinder 36 is rotatably connected to the positioning column 33. Multiple actuating columns 37 are evenly installed on the inner wall of the crushing cylinder 36 from top to bottom and circumferentially. A hemispherical crushing block 371 that abuts against the vertical protrusion 331 is installed on the end of the actuating column 37 near the positioning column 33. The diameter of the crushing cylinder 36 gradually decreases from top to bottom. A material leakage hole is opened at the bottom of the crushing cylinder 36. The diameter of the multiple hemispherical crushing blocks 371 on the inner wall of the crushing cylinder 36 gradually decreases from top to bottom, and the distance between the multiple hemispherical crushing blocks 371 and the positioning column 33 gradually decreases from top to bottom.

[0033] In practice, the solution is first poured into the reaction cylinder 1 from the feed cylinder 31, and then the solid particles are poured into the feed cylinder 31. Since the diameter of the solid particles is larger than the discharge hole, the solid particles will remain in the crushing cylinder 36. At this time, the positioning motor 342 is started, which drives the transmission gear 343 to rotate. The transmission gear 343 drives the annular frame 34, connecting cylinder 35, crushing cylinder 36, and execution column 37 to rotate circumferentially around the axis of the positioning column 33 through the annular gear ring 341. The execution column 37 drives the hemispherical crushing block 371 to cooperate with the vertical protrusion 331 to crush the solid particles. During this process, multiple hemispherical crushing blocks are used to crush the solid particles. The ball crusher 371 can gradually crush solid particles into smaller particles, thereby enabling multi-stage crushing of solid particles to enhance crushing efficiency, reduce the diameter of solid particles, increase the contact area between smaller solid particles and solution, and thus improve the reaction rate. Subsequently, the crushed solid particles fall into the reaction cylinder 1 through the discharge hole. Then, the external vacuum pump is connected to the one-way valve 11 to extract the air from the reaction cylinder 1, making the inside of the reaction cylinder 1 a vacuum state. Then, the solid particles and solution inside the reaction cylinder 1 are vacuum stirred and reacted by the stirring reaction unit 4.

[0034] See Figure 3 , Figure 4 and Figure 5 The diversion assembly 32 includes a discharge cylinder 321. The bottom of the feed cylinder 31 is circumferentially and evenly fitted with discharge cylinders 321 that are connected to it. Multiple sector plates 322 are circumferentially and evenly hinged to the inner wall of the discharge cylinder 321 away from the feed cylinder 31 via torsion springs. Sealing strips are provided between adjacent sector plates 322. Multiple fixing blocks 323, corresponding to the positions of the sector plates 322, are circumferentially and evenly arranged on the inner wall of the discharge cylinder 321. A mounting groove is provided inside the positioning column 33, and an air pump 324 is installed inside the mounting groove. Multiple extension bars are circumferentially and evenly installed at the air outlet end of the air pump 324. The air outlet pipe 325 extends into the discharge cylinder 321, and the air inlet end of the air pump 324 is connected to the outside of the positioning column 33 to facilitate the replenishment of gas. In this embodiment, when there is no external force, the fan-shaped plate 322 rotates towards the side closer to the feed cylinder 31 under the action of the torsion spring and abuts against the fixing block 323. At this time, multiple fan-shaped plates 322 can form a complete circular plate. At this time, the gap between two adjacent fan-shaped plates 322 can be compensated by the setting of the sealing strip, thereby preventing gas leakage in the reaction cylinder 1 and ensuring the sealing of the pharmaceutical intermediate during the reaction process.

[0035] In actual operation, after the solution is poured into the feed cylinder 31, it flows into the discharge cylinder 321 through the leakage hole. Under the gravity of the solution, the fan-shaped plate 322 rotates away from the feed cylinder 31, thus the fan-shaped plate 322 is in an open state. At this time, gaps are formed between adjacent fan-shaped plates 322, and the solution flows out through the gaps. The solution is guided into the reaction cylinder 1 through multiple discharge cylinders 321. When the crushed solid particles are scattered in different discharge cylinders 321, the air pump 324 is started. The air pump 324 blows air into the discharge cylinder 321 through the air outlet pipe 325, so that the fan-shaped plate 322 is always in an open state. This ensures that the solid particles fall smoothly into the reaction cylinder 1 along the discharge cylinder 321. The diversion method formed by multiple discharge cylinders 321, combined with the air blowing action of the air pump 324, can speed up the process of guiding the crushed solid particles into the reaction cylinder 1, thereby saving the filling time of solid particles and preventing the discharge cylinder 321 from clogging.

[0036] See Figure 2 , Figure 7 , Figure 8 and Figure 9 The stirring reaction unit 4 includes electric heating blocks 41. Multiple electric heating blocks 41 are detachably installed inside the reaction cylinder 1 and below the feed cylinder 31. A support plate 421 is installed on the inner wall of the reaction cylinder 1 via circumferentially arranged support rods 42. A drive motor 43 is mounted on the lower end of the support plate 421 via a motor mount. A rotating shaft 44 is installed between the output shaft of the drive motor 43 and the lower end of the feed cylinder 31, and the rotating shaft 44 is rotatably connected to the feed cylinder 31. A linkage plate 45 is sleeved on the outer wall of the rotating shaft 44 and above the support plate 421. The linkage plate 45 is connected to the reaction cylinder. The inner walls are rotatably connected. Multiple discharge ports are opened on the linkage plate 45. A rotating pad 422 is rotatably connected to the upper end of the support plate 421. The rotating pad 422 is sleeved on the outer wall of the rotating shaft 44. A push rod 424 is installed on the upper end of the rotating pad 422 through waterproof cylinders 423 arranged evenly in the circumference. A sealing column 425 corresponding to the position of the discharge port is set on the top of the push rod 424. Multiple conical stirring cylinders 46 are evenly installed in the circumference of the upper end of the linkage plate 45. Multiple through holes are evenly opened through the side wall of the conical stirring cylinder 46. Multiple grinding strips are symmetrically arranged on the outer wall of the conical stirring cylinder 46.

[0037] In the initial state, the telescopic end of the waterproof cylinder 423 is in the extended state. At this time, the push rod 424, under the action of the waterproof cylinder 423, drives the sealing column 425 to insert into the discharge port, so as to close the discharge port (e.g. Figure 2 As shown), ensure that the reaction cylinder 1 on the upper side of the linkage plate 45 is in a sealed state to prevent the solution from flowing out of the feed port, thereby prolonging the reaction time between the solid particles and the solution.

[0038] Continue reading Figure 7 and Figure 8Multiple connecting rods 411 are evenly installed circumferentially on the inner wall of the reaction cylinder 1 above the linkage plate 45. A first heat-conducting rod 412 is provided inside the connecting rod 411 and is engaged with the electric heating block 41. Multiple second heat-conducting rods 413 are installed at equal intervals along the length of the lower end of the first heat-conducting rod 412, which are staggered with the position of the conical stirring cylinder 46. Two triangular plates 414 are symmetrically arranged on the outer wall of the second heat-conducting rod 413. The upper side of the triangular plate 414 is parallel to the length of the first heat-conducting rod 412. The side of the triangular plate 414 away from the second heat-conducting rod 413 is parallel to the grinding strip. A material passage hole 415 is opened on the triangular plate 414. Multiple combing strips 416 are installed at equal intervals from top to bottom inside the material passage hole 415.

[0039] In practice, after the air in the reaction cylinder 1 is evacuated, the electric heating block 41 is activated to heat the solution in the reaction cylinder 1. The electric heating block 41, through the first heat-conducting rod 412 and the second heat-conducting rod 413, heats the solution inside the reaction cylinder 1, ensuring comprehensive heating and accelerating the dissolution rate of the solid particles. Simultaneously, the drive motor 43 is activated, driving the linkage plate 45 to rotate via the rotating shaft 44. The linkage plate 45 then drives the conical stirring cylinder 46 to stir the solid particles and solution in the reaction cylinder 1. At this time, the solution and solid particles in the reaction cylinder 1 are rotating. Since the second heat-conducting rod 413 and the triangular plate 414 are stationary, therefore... The second heat-conducting rod 413 and the triangular plate 414 can apply opposite forces to the solution and solid particles, causing them to move in opposite directions relative to the solution. This allows the triangular plate 414 and the combing strip 416 to stir the solid particles and solution in opposite directions, thereby accelerating the reaction rate between the solid particles and the solution and ensuring a uniform reaction. During this process, the grinding strip and the triangular plate 414 can perform secondary pulverization of the solid particles, breaking them down into tiny particles. This further increases the contact area between the solid particles and the solution, further accelerating the reaction rate. Subsequently, the solid particles and solution react to form a pharmaceutical intermediate.

[0040] After the pharmaceutical intermediate reaction is complete, a dedicated collection container is placed at the lower end of the discharge port. Then, the waterproof cylinder 423, through the push rod 424, drives the sealing column 425 to be pulled out of the discharge port and moved downwards (e.g., Figure 9 As shown), the pharmaceutical intermediate flows into the collection container after passing through the feed port and discharge port in sequence. At this time, the rotating shaft 44 continues to drive the linkage plate 45 to rotate, so that the solution at the upper end of the linkage plate 45 is thrown out into the feed port under the action of centrifugal force, thereby ensuring that the solution is completely discharged.

[0041] The working process of this invention is as follows: S1: First, the solution is poured into the feed cylinder 31. After passing through the leakage hole and the discharge cylinder 321, the solution flows into the reaction cylinder 1. Then, the solid particles are poured into the feed cylinder 31. At this time, the positioning motor 342 is started. The positioning motor 342 drives the transmission gear 343 to rotate. The transmission gear 343 drives the ring frame 34, the connecting cylinder 35, the crushing cylinder 36 and the execution column 37 to rotate circumferentially around the axis of the positioning column 33 through the ring gear ring 341. The crushing cylinder 36 drives multiple hemispherical crushing blocks 371 to cooperate with the vertical protrusions 331 to perform multi-stage crushing of the solid particles, thereby reducing the diameter of the solid particles.

[0042] S2: When the crushed solid particles are scattered into different discharge cylinders 321 after passing through the discharge hole, the air pump 324 is started. The air pump 324 blows air into the discharge cylinder 321 through the air outlet pipe 325, so that the fan-shaped plate 322 is always in an open state, thereby ensuring that the solid particles fall smoothly into the reaction cylinder 1 along the discharge cylinder 321. Then, the external vacuum pump is connected to the one-way valve 11 and the air in the reaction cylinder 1 is extracted, so that the reaction cylinder 1 is in a vacuum state.

[0043] S3: Start the electric heating block 41. The solution inside the reaction cylinder 1 is heated by the electric heating block 41, the first heat-conducting rod 412 and the second heat-conducting rod 413, so that the solution is heated in all directions. At the same time, start the drive motor 43. The drive motor 43 drives the linkage plate 45 to rotate through the rotating shaft 44. The linkage plate 45 drives the conical stirring cylinder 46 to stir the solid particles and solution in the reaction cylinder 1. At this time, the solid particles and solution are stirred in reverse by the triangular plate 414 and the combing strip 416. During this period, the solid particles can be pulverized a second time by the grinding strip and the triangular plate 414, so that the solid particles are pulverized into tiny particles, thereby further accelerating the reaction rate between the solid particles and the solution. Subsequently, the solid particles and solution react to form a pharmaceutical intermediate.

[0044] S4: After the pharmaceutical intermediate reaction is completed, a special collection container is placed at the lower end of the discharge port. Then, the waterproof cylinder 423 drives the sealing column 425 to be pulled out from the discharge port and moved downward through the push rod 424, so that the pharmaceutical intermediate flows into the collection container after passing through the discharge port and the discharge port in sequence, thereby completing the collection of the pharmaceutical intermediate.

[0045] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A pharmaceutical intermediate vacuum reaction apparatus, characterized by, The reaction cylinder (1) includes a discharge port at the bottom and a through hole at the top. A one-way valve (11) is installed inside the through hole. Two support plates (2) are symmetrically arranged at the bottom of the reaction cylinder (1). A pulverizing unit (3) is installed on the upper side of the reaction cylinder (1). A flow divider (32) is installed inside the pulverizing unit (3). A stirring reaction unit (4) is installed inside the reaction cylinder (1). A heating unit is installed inside the reaction cylinder (1). The pulverizing unit (3), the flow divider (32), the stirring reaction unit (4) and the heating unit cooperate to complete the rapid and uniform reaction of the pharmaceutical intermediate. The crushing unit (3) includes a feeding cylinder (31), the upper end of the reaction cylinder (1) is equipped with the feeding cylinder (31), the lower end of the feeding cylinder (31) extends into the interior of the reaction cylinder (1), the bottom of the feeding cylinder (31) is equipped with a diversion component (32), the inner bottom wall of the feeding cylinder (31) is provided with a positioning column (33), the inner side wall of the feeding cylinder (31) is rotatably connected with an annular frame (34), the inner side wall of the annular frame (34) is equipped with a crushing cylinder (36) through a connecting cylinder (35), the bottom of the crushing cylinder (36) is rotatably connected with the positioning column (33), and multiple execution columns (37) are evenly installed on the inner wall of the crushing cylinder (36). The stirring reaction unit (4) includes an electric heating block (41). Multiple electric heating blocks (41) are installed inside the reaction cylinder (1) and below the feed cylinder (31). A support plate (421) is installed on the inner wall of the reaction cylinder (1) via a support rod (42). A drive motor (43) is installed at the lower end of the support plate (421) via a motor seat. A rotating shaft (44) is installed between the output shaft of the drive motor (43) and the lower end of the feed cylinder (31). A linkage plate (45) is sleeved on the outer wall of the rotating shaft (44) and above the support plate (421). The linkage plate (45) is rotatably connected to the inner wall of the reaction cylinder (1). Multiple discharge ports are opened on the linkage plate (45). Multiple conical stirring cylinders (46) are evenly installed on the upper end of the linkage plate (45). Multiple through holes are evenly opened on the side wall of the conical stirring cylinder (46). Multiple grinding strips are provided on the outer wall of the conical stirring cylinder (46). The heating unit includes multiple connecting rods (411) that are uniformly installed circumferentially on the inner wall of the reaction cylinder (1) and located on the linkage plate (45). The connecting rods (411) are provided with a first heat-conducting rod (412) that is engaged with the electric heating block (41). The lower end of the first heat-conducting rod (412) is provided with multiple second heat-conducting rods (413) that are equally spaced along its length and are staggered with the position of the conical stirring cylinder (46). Two triangular plates (414) are symmetrically arranged on the outer wall of the second heat-conducting rod (413). The upper side of the triangular plate (414) is parallel to the length direction of the first heat-conducting rod (412). The side of the triangular plate (414) away from the second heat-conducting rod (413) is parallel to the grinding strip. A material passage hole (415) is opened on the triangular plate (414). Multiple combing strips (416) are installed at equal intervals from top to bottom inside the material passage hole (415).

2. The vacuum reaction equipment for pharmaceutical intermediates according to claim 1, characterized in that: The diversion component (32) includes a discharge cylinder (321). The bottom of the feed cylinder (31) is uniformly circumferentially mounted with a discharge cylinder (321) connected to it. On the side of the inner wall of the discharge cylinder (321) away from the feed cylinder (31), a plurality of fan-shaped plates (322) are uniformly hinged circumferentially by a torsion spring. A sealing strip is provided between adjacent fan-shaped plates (322). A plurality of fixing blocks (323) corresponding to the positions of the fan-shaped plates (322) are uniformly arranged circumferentially on the inner wall of the discharge cylinder (321). An installation groove is opened inside the positioning column (33). An air pump (324) is provided inside the installation groove. A plurality of air outlet pipes (325) extending into the discharge cylinder (321) are uniformly installed circumferentially at the air outlet end of the air pump (324).

3. The vacuum reaction apparatus for pharmaceutical intermediates according to claim 1, characterized in that: The top of the positioning column (33) is a tapered structure with a diameter that gradually increases from top to bottom. Multiple vertical protrusions (331) are evenly distributed on the outer wall of the positioning column (33). A hemispherical crushing block (371) that abuts against the vertical protrusions (331) is installed on one end of the execution column (37) near the positioning column (33).

4. The vacuum reaction apparatus for pharmaceutical intermediates according to claim 3, wherein: The diameter of the crushing cylinder (36) gradually decreases from top to bottom. A material leakage hole is provided at the bottom of the crushing cylinder (36). The diameter of the multiple hemispherical crushing blocks (371) on the inner wall of the crushing cylinder (36) gradually decreases from top to bottom, and the distance between the multiple hemispherical crushing blocks (371) and the positioning column (33) gradually decreases from top to bottom.

5. The vacuum reaction apparatus for pharmaceutical intermediates according to claim 1, wherein: The upper end of the support plate (421) is rotatably connected to a rotating pad (422), which is sleeved on the outer wall of the rotating shaft (44). The upper end of the rotating pad (422) is equipped with a push rod (424) through a circumferentially evenly arranged waterproof cylinder (423). The top of the push rod (424) is provided with a sealing column (425) corresponding to the position of the discharge port.

6. The vacuum reaction apparatus for pharmaceutical intermediates according to claim 1, characterized in that: The outer wall of the ring frame (34) is fitted with an annular gear ring (341). A positioning motor (342) is installed at the upper end of the reaction cylinder (1) and on any side of the feed cylinder (31). The output shaft of the positioning motor (342) is fitted with a transmission gear (343) that meshes with the annular gear ring (341).

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