A kit for the detection of parathyroid blood supply

Abstract

The present application belongs to the technical field of kits, and particularly relates to a detachable kit for parathyroid blood supply detection, which comprises a box body, an openable box cover arranged at the top of the box body, a developing solution injection mechanism, a liquid medicine injection mechanism and a three-way connecting mechanism arranged in the box body, a first end of the three-way connecting mechanism being connected with the developing solution injection mechanism, a second end of the three-way connecting mechanism being connected with the liquid medicine injection mechanism, and a third end of the three-way connecting mechanism being used for connecting a remaining needle, the three-way connecting mechanism being capable of being switched between a developing solution injection function and a reagent injection function. The kit designed in the present application is used in cooperation with developing reagents such as indocyanine green aqueous solution, and can guide a doctor to make a decision on whether to retain or transplant parathyroid glands, or help the doctor to find a position of a parathyroid adenoma to be removed during a total thyroidectomy and central lymph node dissection surgery or a parathyroid adenoma resection surgery. The device can be repeatedly used, material is saved, the environment is protected, mechanical injection is achieved, and efficiency is high.

Description

Technical Field

[0001] This invention belongs to the field of reagent kit technology, specifically relating to a detachable reagent kit for detecting parathyroid blood supply. Background Technology

[0002] The parathyroid glands are small, about 3-5 mm in diameter, located near the thyroid gland, and are round or oval in shape. They are one of the important endocrine glands in the human body. The cells within the parathyroid gland are divided into chief cells and acidophilic cells. The chief cells constitute the parenchymal gland, secreting parathyroid hormone, which participates in the metabolism of calcium and phosphorus in the body. They also act on the intestines and renal tubules, and their function is crucial for maintaining normal human health. The parathyroid glands mainly receive blood from branches of the inferior thyroid artery, but can also receive blood from anastomoses between the superior and inferior thyroid arteries or from the inferior thyroid artery. Because the blood vessels of normal parathyroid glands are very fine, they are not easily visible to the naked eye. Therefore, when lesions within the thyroid gland, such as thyroid cancer invading the blood supply to the parathyroid glands, or when surgical removal of the parathyroid glands damages the blood supply, the blood supply to the parathyroid glands will be affected, thus affecting their physiological function and consequently harming human health. Therefore, detecting the blood supply and hormone secretion status of the parathyroid glands is a very useful examination for assessing their function. Secondly, when parathyroid gland lesions (such as parathyroid adenomas) require surgical removal, doctors need to visually identify their location. Therefore, detecting the location of the parathyroid glands is also a very useful examination.

[0003] Chinese patents disclose various methods for detecting the health status and location of the parathyroid glands. For example, CN109847072A discloses a parathyroid blood supply detection kit containing an indocyanine green aqueous solution. The indocyanine green aqueous solution is injected into the human body through a peripheral vein, and the blood supply of the parathyroid glands is observed through fluorescence to determine whether it is normal. This kit can help doctors accurately determine whether the blood supply of the parathyroid glands is damaged. In total thyroidectomy and central lymph node dissection, it can guide doctors in deciding whether to preserve or transplant the parathyroid glands, thereby reducing the incidence of postoperative complications such as temporary and permanent hypoparathyroidism and improving the safety of thyroid surgery. For example, CN108152273A discloses a parathyroid hormone kit for detecting peripheral blood, its preparation method, and its application. This kit includes a parathyroid hormone immunochromatographic assay card and a release agent. The parathyroid hormone immunochromatographic assay card includes a test strip, which includes a test line and a control line. The test line is coated with a mouse anti-human parathyroid hormone monoclonal antibody, and the control line is coated with a goat anti-rabbit polyclonal antibody. The parathyroid hormone kit provided by this patent has high sensitivity, strong stability, and a wide linear range, exhibiting excellent accuracy and precision. Many kits for testing parathyroid function are also available on the market, such as the human parathyroid hormone-related protein (PTHrP) ELISA detection kit – Yuntai, etc.

[0004] As can be seen from the above-mentioned publicly disclosed literature and products, the main principle of a parathyroid function detection kit is to select a characteristic target substance or target tissue and then use specific reagents for detection or treatment. However, these products do not consider the assistance of a "mechanical mechanism" for detection. Taking CN109847072A as an example, this patent only emphasizes injecting indocyanine green aqueous solution into the human body through the peripheral vein, and then observing whether the blood supply of the parathyroid gland is normal through fluorescence. The imaging agent is generally stored in a syringe and then injected into the vein through an indwelling needle. There is no injection mechanism配套 with this parathyroid detection imaging reagent. It is necessary to manually suck out the liquid medicine from the reagent bottle in the kit first, and then manually inject it into the indwelling needle, and finally flow into the vein. The medical devices consumed mainly include a syringe and an indwelling needle. The indwelling needle can also be used to inject other liquid medicines, but the syringe for injecting the imaging agent cannot be reused, resulting in relatively large waste and being unfavorable to environmental protection.

[0005] Secondly, the number of parathyroid glands in the human body is mostly 4, which are located at different positions on the dorsal side of the thyroid gland. During a thyroid surgery, it may be necessary to detect the blood supply of parathyroid glands at different positions multiple times. During a parathyroid adenoma surgery, there is also a need to perform imaging and observe the position multiple times. By manual means, injecting repeatedly multiple times is inefficient. Summary of the Invention

[0006] To solve the above technical problems, the present invention provides a detachable kit for detecting the blood supply of the parathyroid gland.

[0007] The object of the present invention is to provide a detachable kit for detecting the blood supply of the parathyroid gland, including a box body. The top of the box body is provided with an openable box cover. Inside the box body, there are provided a contrast agent injection mechanism, a liquid medicine injection mechanism, and a three-way connection mechanism. The first end of the three-way connection mechanism is connected to the contrast agent injection mechanism, the second end is connected to the liquid medicine injection mechanism, and the third end is used to connect to an indwelling needle. The three-way connection mechanism can switch between the contrast agent injection function and the reagent injection function, and the three-way connection mechanism is not simultaneously connected to the contrast agent injection mechanism and the liquid medicine injection mechanism.

[0008] Preferably, for the above-mentioned detachable kit for detecting the blood supply of the parathyroid gland, the top surface and one side surface of the box body are in an open state, and a shielding surface is provided at a position of the box cover on the same side as the open side surface of the box body.

[0009] Preferably, for the above-mentioned detachable kit for detecting the blood supply of the parathyroid gland, the three-way connection mechanism includes an outlet, a contrast agent inlet, and a reagent inlet. The outlet is connected to the contrast agent inlet, or the outlet is connected to the reagent inlet.

[0010] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, the three-way connection mechanism further includes an outer shell. The outer shell is disposed within the box and has an outlet, a developer inlet, and a reagent inlet. A three-way tube is provided within the outer shell. The first end of the three-way tube is connected and communicates with the outlet, the second end is connected and communicates with the developer inlet, and the third end is connected and communicates with the reagent inlet. A flow-blocking device is provided at the junction of the three-way tubes. The flow-blocking device is used to switch the kit between the developer injection function and the reagent injection function.

[0011] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, the flow-blocking device includes a rotating shaft and a flow-blocking plate. The rotating shaft is installed at the junction of the three-way tube, and the flow-blocking plate is connected to the rotating shaft along its axial direction. The flow-blocking plate can contact the inner wall of the three-way tube and, together with the rotating shaft, can block one liquid flow path of the developing solution inlet or the reagent inlet. The rotating shaft is provided with a drive device to control its rotation.

[0012] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, the driving device is a handle, the rotating shaft passes through the outer shell and the three-way tube, and a sealing device is provided at the connection point of the three, and the part of the rotating shaft located outside the outer shell is connected to the handle;

[0013] Alternatively, the driving device is a controller, and the flow-blocking device further includes a first float and a second float;

[0014] The first float is located on the side of the intercepting plate near the developer inlet. The intercepting plate is provided with a first pressure sensor that can contact the first float. A first elastic rope is provided around the outer periphery of the first float, and a first arc frame is provided around the outer periphery of the first elastic rope. When there is no liquid flow, the first float is separated from the first pressure sensor. Under the impact force of the liquid, the first float contacts the first pressure sensor, and the first pressure sensor generates a pressure signal.

[0015] The second float is located on the side of the throttling plate near the drug inlet. The throttling plate is provided with a second pressure sensor that can contact the second float. A second elastic rope is provided around the outer periphery of the second float, and a second arc frame is provided around the outer periphery of the second elastic rope. When there is no liquid flow, the second float is separated from the second pressure sensor. Under the impact force of the liquid, the second float contacts the second pressure sensor, and the second pressure sensor generates a pressure signal.

[0016] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, the contrast agent injection mechanism includes a first syringe and a first power unit, the front end of the first syringe is provided with a first connecting tube, and the first connecting tube is detachably connected to the contrast agent inlet;

[0017] The structure of the drug injection mechanism is the same as that of the developer injection mechanism.

[0018] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, the first power device is a peristaltic pump;

[0019] Alternatively, the first power device is a telescopic motor, and the tail end of the first injection cylinder is provided with the front end of a push rod. The tail end of the push rod is connected to the telescopic end of the telescopic motor, and the fixed end of the telescopic motor is installed on the side wall of the box body opposite to the side opening.

[0020] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, the inner wall of the box is also provided with a control panel, the control panel is provided with working switches corresponding to the first power unit and the second power unit respectively, and the controller is electrically connected to the first pressure sensor, the second pressure sensor, the first power unit, the second power unit, the power supply and the control panel respectively.

[0021] Preferably, in the above-mentioned detachable parathyroid blood supply detection kit, a support plate is longitudinally arranged on one side of the box near its side opening. The support plate is provided with a first bayonet and a second bayonet. The first bayonet is connected to the contrast agent injection mechanism, and the second bayonet is connected to the drug injection mechanism.

[0022] The three-way connecting mechanism is located between the side opening of the box and the support plate.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] 1. The reagent kit designed in this invention can be used with contrast agents such as indocyanine green aqueous solution. During total thyroidectomy and central lymph node dissection, it can guide surgeons in deciding whether to preserve or transplant parathyroid glands, thereby reducing the incidence of postoperative temporary and permanent hypoparathyroidism and improving the safety of thyroid surgery. Furthermore, based on fluorescence observation results, it can rapidly detect PTH and other diagnostic indicators of parathyroid glands in pathological tissue or blood samples from suspected parathyroid lesions with higher accuracy.

[0025] 2. The detachable developer injection mechanism and drug injection mechanism designed in this invention facilitate the holding and replacement of various reagents, are reusable, save materials and are environmentally friendly, and provide mechanized injection with high efficiency.

[0026] 3. The present invention features a specially designed three-way connection mechanism with a compact structure, which enables the reagent kit to switch between developing solution injection and reagent injection functions without worrying about cross-contamination between reagents. It only needs to be connected to the indwelling needle once to complete multiple drug deliveries, saving time and effort.

[0027] 4. Embodiment 2 of the present invention provides a three-way connection mechanism for automatically switching infusion lines, which has a high degree of automation. Attached Figure Description

[0028] Figure 1 This is a schematic diagram of the opened structure of the detachable parathyroid blood supply detection kit according to Embodiment 1 of the present invention;

[0029] Figure 2 This is a diagram showing the internal structure of the reagent kit of Embodiment 1 of the present invention after removing the lid and the front side of the kit.

[0030] Figure 3 This is a diagram showing the positional relationship between the box body and the three-way connection mechanism in Embodiment 1 of the present invention;

[0031] Figure 4 This is a longitudinal section view of the three-way connection mechanism according to Embodiment 1 of the present invention;

[0032] Figure 5 for Figure 4 Enlarged view of part A;

[0033] Figure 6 for Figure 5 Usage status diagram;

[0034] Figure 7 for Figure 6 Cross-sectional view of the structure after longitudinal sectioning along the rotation axis;

[0035] Figure 8 This is a three-dimensional structural diagram of the flow-blocking device according to Embodiment 2 of the present invention;

[0036] Figure 9 for Figure 8 The left view;

[0037] Figure 10 This is a module connection diagram of Embodiment 2 of the present invention. Detailed Implementation

[0038] To enable those skilled in the art to better understand and implement the technical solutions of the present invention, the present invention will be further described below in conjunction with specific embodiments and accompanying drawings.

[0039] In the description of this invention, unless otherwise specified, all reagents used are commercially available, and all methods used are conventional techniques in the art. In the description of the embodiments of this invention, the "reagent injection function" of claim 1 is exemplarily described using the "physiological saline injection function".

[0040] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined with "first" or "second" may explicitly or implicitly include one or more of that feature; in the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0041] Example 1

[0042] A removable kit for detecting parathyroid blood supply, see [link to kit]. Figure 1-7 The box includes a box body 1, with its top and one side open. The top of the box body 1 has an openable lid 2. Based on user habits, the lid 2 can be hinged to the box body 1, meaning the lid 2 can be opened from the top. Figure 1 The box opens from the front to the rear, and a shielding surface 21 is provided on the same side as the open side of the box body 1. Figure 1 In this design, the top and left sides of the box body 1 are set to an open state, and the left side of the box cover 2 is provided with a shielding surface 21. When the box cover 2 is closed on the box body 1, the shielding surface 21 can close the left open part of the box body 1. When the box cover 2 is opened, the shielding surface 21 is separated from the left open part of the box body 1. The left side of the box body 1 is set to an open state to facilitate the connection between the indwelling needle and the three-way connecting mechanism 5. The top of the box body 1 is set to an open state to facilitate the installation of the developer injection mechanism 3 and the drug injection mechanism 4.

[0043] The kit body 1 contains a contrast agent injection mechanism 3, a medication injection mechanism 4, and a three-way connector 5. The contrast agent injection mechanism 3 is used to hold contrast agents such as indocyanine green aqueous solution. After these contrast agents are injected into the body, it is convenient to observe the function of the parathyroid glands. The medication injection mechanism 4 is used to hold reagents such as physiological saline. Because normally, contrast agents need to be injected into a vein through an indwelling needle, and a certain amount of physiological saline needs to be injected before the medication is injected into the vein through the indwelling needle, the kit of this invention simultaneously includes a contrast agent injection mechanism 3 and a medication injection mechanism 4 for the convenience of medical personnel. The three-way connector 5 of this invention is used to connect the contrast agent injection mechanism 3, the medication injection mechanism 4, and the indwelling needle, and the three-way connector 5 can switch between the contrast agent injection function and the physiological saline injection function, that is, the three-way connector 5 is not simultaneously connected to the contrast agent injection mechanism 3 and the medication injection mechanism 4. The three-way connection mechanism 5 includes an outlet 51, a developer inlet 52, and a reagent inlet 53. The outlet 51 is connected to the developer inlet 52, or the outlet 51 is connected to the reagent inlet 53. The three-way connection mechanism 5 does not have three interconnected ends, but only two ends are always connected, thus avoiding the mixing of liquids in the developer injection mechanism 3 and the reagent injection mechanism 4. The three-way connection mechanism 5 is used to control the switching between the developer injection function and the saline injection function.

[0044] The kit designed in this invention, when used with contrast agents such as indocyanine green aqueous solution and fluorescent reagents, can guide surgeons in total thyroidectomy and central lymph node dissection surgeries regarding decisions on whether to preserve or transplant parathyroid glands. This reduces the incidence of postoperative complications such as temporary and permanent hypoparathyroidism, improving the safety of thyroid surgery. Furthermore, based on fluorescence observation results, pathological tissue or blood samples from suspected parathyroid lesions can be removed, and other diagnostic indicators such as PTH can be rapidly detected. Using multiple diagnostic results in combination increases accuracy.

[0045] See Figure 1-2The developer injection mechanism 3 includes a first injection cylinder 31 and a first power unit. The front end of the first injection cylinder 31 is provided with a first connecting tube 32, which can be connected and communicate with the developer inlet 52. Preferably, the first connecting tube 32 and the developer inlet 52 are detachably plugged in, and a sealing ring can be fitted between them to prevent leakage at the connection. The rear end of the first injection cylinder 31 is provided with the first power unit, which is used to deliver the liquid in the first injection cylinder 31 into the developer inlet 52. Specifically, the first power unit is a peristaltic pump, which is connected to the first injection cylinder 31. The first injection cylinder 31 is provided with a reagent adding port, or the first connecting tube 32 can be used as the reagent adding port. When a peristaltic pump is used as the first power unit, the first injection cylinder 31 connected to it is made of soft plastic material, which is deformable, thus facilitating the installation of the peristaltic pump. Alternatively, the first power device is a telescopic motor 34, and a push rod 33 is provided inside the tail end of the first syringe 31. The outer wall of the front end of the push rod 33 contacts the inner wall of the first syringe 31, simulating the action of a syringe. The tail end of the push rod 33 is connected to the telescopic end of the telescopic motor 34, and the fixed end of the telescopic motor 34 is installed on the side wall of the box 1 opposite to the side opening. That is to say, the fixed end of the telescopic motor 34 is installed on... Figure 1 On the inner wall of the right side of the box 1 shown, when the telescopic motor 34 is used as the first power device, the first injection cylinder 31 is made of a hard cylinder, which makes it convenient for the telescopic motor 34 to control the push rod 33. At this time, the output shaft end of the telescopic motor 34 and the tail end of the push rod 33 can be detachably snapped together.

[0046] The structure of the drug injection mechanism 4 is the same as that of the developer injection mechanism 3, including a second injection cylinder 41, a second connecting tube 42 and a second power device. The working principle of the drug injection mechanism 4 and the developer injection mechanism 3 is the same. The difference is that the second injection cylinder 41 of the drug injection mechanism 4 contains reagents such as physiological saline, while the first injection cylinder 31 of the developer injection mechanism 3 contains developer such as indocyanine green aqueous solution.

[0047] A support plate 11 is longitudinally arranged on one side of the housing 1 near its open side. The support plate 11 has a first latch 111 and a second latch 112. The first latch 111 supports the contrast agent injection mechanism 3, and the second latch 112 supports the drug injection mechanism 4. Specifically, the first latch 111 engages with the outer wall of the first connecting tube 32, and the second latch 112 engages with the outer wall of the second connecting tube 42. The first connecting tube 32 and the second connecting tube 42 are analogous to the form of a "medical syringe" without a needle, used for drawing in and injecting liquid. Preferably, to facilitate the engagement of the first connecting tube 32 and the second connecting tube 42, both the first latch 111 and the second latch 112 are U-shaped latches with an open top.

[0048] Reference Figure 3-4The three-way connection mechanism 5 includes an outer shell 50, which is disposed inside the housing 1 and located between the side opening of the housing 1 and the support plate 11. A developer inlet 52 and a reagent inlet 53 are provided on the side wall of the outer shell 50 near the support plate 11. An outlet 51 is provided on the other side wall of the outer shell 50 opposite to the developer inlet 52 and the reagent inlet 53. A three-way pipe 54 is provided inside the outer shell 50. The first end of the three-way pipe 54 is connected to and communicates with the outlet 51, the second end of the three-way pipe 54 is connected to and communicates with the developer inlet 52, and the third end of the three-way pipe 54 is connected to and communicates with the reagent inlet 53. Sealing rings are provided at the joints of the three-way pipe 54 with other components to prevent leakage. A flow-stopping device 55 is provided at the intersection of the three-way pipe 54; that is, the three-way pipe 54 is Y-shaped, and a flow-stopping device 55 is provided at the intersection of the Y-shape. The flow-blocking device 55 is used to block the flow from the outlet 51 to the developer inlet 52 and to connect the outlet 51 to the reagent inlet 53; or the flow-blocking device 55 is used to block the outlet 51 to the reagent inlet 53 and to connect the outlet 51 to the developer inlet 52. The flow-blocking device 55 is used to switch the reagent kit between the developer injection function and the saline injection function.

[0049] For the specific structure of the flow interceptor 55, please refer to Figure 5-7 It includes a rotating shaft 551 and a flow cut-off plate 552. The rotating shaft 551 is installed at the intersection of the Y-shape. The rotating shaft 551 is perpendicular to the inner wall of the section of the three-way pipe 54 near the outlet 51 and is rotatably connected to the inner wall of the three-way pipe 54. For example, refer to Figure 7 When the inner wall of the section of the three-way pipe 54 near the liquid outlet 51 is cylindrical, the upper semicircle at the intersection of the Y-shape is the same as the developer inlet 52, and the lower semicircle is connected to the reagent inlet 53. The rotating shaft 551 is located on the straight line of the cylindrical diameter and is rotatably connected to the inner wall of the cylinder. A semicircular flow-blocking plate 552 is connected to the rotating shaft 551 along its axial direction. The flow-blocking plate 552 can contact the inner wall of the three-way pipe 54 and can block one liquid flow path of the developer inlet 52 or the reagent inlet 53 together with the rotating shaft 551. A sealing sleeve is provided on the outer edge of the flow-blocking plate 552. The sealing sleeve is both flexible and sealing, and has good use and sealing effect.

[0050] This embodiment employs a manually controlled flow-stopping device 55. A handle is provided on the outside of the outer casing 50, which serves as the drive device for controlling the rotation of the rotating shaft 551. A through-hole is provided at the Y-shaped intersection of the outer casing 50 and the three-way pipe 54. The rotating shaft 551 passes through the through-hole in both the outer casing 50 and the three-way pipe 54 and is fixedly connected to the handle. By rotating the handle, the rotating shaft 551 can be rotated, which in turn drives the flow-stopping plate 552 to rotate. Figure 5 The diagram shows that the baffle plate 552 blocks the passage at one end of the drug inlet 53. Figure 6The diagram shows that the baffle plate 552 blocks the flow of the developer inlet 52 at one end. To prevent leakage, a sealing device, which is either sealing oil or a gasket, is provided at the connection between the perforation and the rotating shaft 551.

[0051] According to the usual practice of intravenous infusion with indwelling needles, a certain amount of saline is usually injected first, followed by a quantitative dose of medication, and finally, saline is injected again. The reagent kit structure designed in this invention can inject both indocyanine green aqueous solution and other contrast agents, as well as saline. Furthermore, when injecting saline, the intercepting device 55 blocks the passage at one end of the contrast agent inlet 52, so the saline will not contaminate the contrast agent. When injecting contrast agent, the passage at one end of the medication inlet 53 is blocked, so the saline end will not be contaminated. There is no need to worry about cross-contamination between reagents. Multiple drug deliveries can be completed by connecting to the indwelling needle only once, saving time and effort.

[0052] Example 2

[0053] A detachable parathyroid blood supply detection kit, with a structure basically the same as that in Example 1, differs in that:

[0054] The flow-stopping device 55 adopts an automatic control structure. In this embodiment, the flow-stopping device 55 does not include a handle, and the rotating shaft 551 does not penetrate the tee pipe 54. For the structure of the flow-stopping device 55, please refer to [link to relevant documentation]. Figure 8-9 It includes a rotating shaft 551, a flow-blocking plate 552, a first float 553, and a second float. The rotating shaft 551 is installed at the intersection of the Y-shape. When the inner wall of the three-way pipe 54 is cylindrical, the rotating shaft 551 is located on the diameter of the cylinder and is rotatably connected to the inner wall of the cylinder. The rotating shaft 551 is connected to a semi-circular flow-blocking plate 552 along its axial direction. The flow-blocking plate 552 can contact the inner wall of the three-way pipe 54 and can, together with the rotating shaft 551, block one liquid flow passage of the developer inlet 52 or the reagent inlet 53.

[0055] The first float 553 is located on the side of the throttling plate 552 near the developer inlet 52, corresponding to the developer inlet 52. Liquid entering from the developer inlet 52 first contacts the first float 553, and then contacts the throttling plate 552. The throttling plate 552 is equipped with a first pressure sensor 5521 that can contact the first float 553. A first elastic rope 5531 is arranged around the outer periphery of the first float 553, and a first arc frame 5532 is arranged around the outer periphery of the first elastic rope 5531. One end of the first elastic rope 5531 is fixedly connected to the first arc frame 5532, and the other end is fixedly connected to the first float 553. When there is no liquid flow, the first float 553 is pulled by the first elastic rope 5531 and is separated from the first pressure sensor 5521, not in contact. When liquid rushes towards the first float 553, under the impact force of the liquid, the first float 553 contacts the first pressure sensor 5521, and the first pressure sensor 5521 generates a pressure signal.

[0056] The second float has a basically the same structure and working principle as the first float 553. The second float corresponds to the reagent inlet 53 and is located on the side of the throttling plate 552 near the reagent inlet 53. A second pressure sensor that can contact the second float is provided on the throttling plate 552. Liquid entering from the reagent inlet 53 first contacts the second float and then contacts the throttling plate 552. A second elastic rope is provided around the outer periphery of the second float, and a second arc frame is provided around the outer periphery of the second elastic rope. One end of the second elastic rope is fixedly connected to the second arc frame, and the other end is fixedly connected to the second float. When there is no liquid flow, the second float is pulled by the second elastic rope and is separated from the second pressure sensor, not in contact. When liquid rushes towards the second float, under the impact force of the liquid, the second float contacts the second pressure sensor 5522, and the second pressure sensor 5522 generates a pressure signal.

[0057] The drive device uses a controller, which is a PLC controller or an 89C51 series controller, etc. The controller is electrically connected to the first pressure sensor 5521, the second pressure sensor 5522, the first power unit, and the second power unit. The inner wall of the box 1 is also equipped with a control panel, which has working switches corresponding to the first power unit and the second power unit respectively. The control panel is also electrically connected to the controller, which is also connected to a power supply. By pressing the working switch, the corresponding first power unit and the second power unit work to control the addition of developing reagent and physiological saline.

[0058] In this embodiment, the initial state of the intercepting device 55 is to intercept one end of the developer inlet 52, that is, see [reference needed]. Figure 6In this structure, when injecting saline solution, the saline solution flows from the inlet 53 to the outlet 51. The first float is not compressed and therefore does not contact the first pressure sensor 5521. The flow-blocking device 55 continuously blocks one end of the developer inlet 52. At this time, the controller disables the first power unit while the second power unit operates. When it is necessary to inject the developing reagent, the controller's second power unit stops operating, stopping the injection of saline solution. The pressure on the second float disappears, and the corresponding pressure signal from the second pressure sensor 5522 also disappears. The controller's first power unit then starts operating, and the developing reagent flows from the developer inlet 52 to the outlet 51, compressing the first float. The first float 553 then contacts the first pressure sensor 5521. The first pressure sensor 5521 receives the pressure signal and transmits it to the controller. The controller then controls the rotating shaft 551 to rotate a certain angle, causing the flow-blocking plate 552 to rotate to... Figure 5 The indicated position will cut off the flow from the drug inlet 53. When saline solution needs to be injected again, the controller disables the first power unit and activates the second power unit. The second float then contacts the second pressure sensor 5522, generating a pressure signal that is transmitted to the controller. The controller then controls the rotating shaft 551 to rotate a certain angle, causing the cut-off plate 552 to rotate to... Figure 6 The position shown will cut off the flow from the developer inlet 52.

[0059] Preferably, to prevent the first pressure sensor 5521 and the second pressure sensor 5522 from receiving erroneous pressure signals, the first elastic rope 5531 can be replaced with a first elastic waterproof surface. The outer periphery of the first elastic waterproof surface is provided with a first arc frame 5532. When the first arc frame 5532 contacts the flow-cutting plate 552 and there is no pressure applied, the first float 553 separates from the first pressure sensor 5521. Similarly, the second elastic rope can be replaced with a second elastic waterproof surface. The outer periphery of the second elastic waterproof surface is provided with a second arc frame. When the second arc frame contacts the flow-cutting plate 552 and there is no pressure applied, the second float separates from the second pressure sensor.

[0060] The flow-stopping device 55 in this embodiment is automatically controlled and has a high degree of automation. It not only avoids leakage but also prevents contamination of the reagents by hand.

[0061] It should be noted that in the above embodiments, all components are made of materials that can be disinfected and reused, so that the device can be reused, avoiding waste and saving resources and protecting the environment.

[0062] It should be noted that the connection relationships of components not specifically mentioned in this invention are all assumed to be based on existing technology. Since they do not involve the inventive point and are commonly used in existing technology, the structural connection relationships are not described in detail.

[0063] It should be noted that when numerical ranges are involved in this invention, it should be understood that both endpoints of each numerical range and any value between the two endpoints can be selected. Since the steps and methods used are the same as in the embodiments, preferred embodiments are described here to avoid redundancy. Although preferred embodiments of the invention have been described, those skilled in the art, once they understand the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of this invention.

[0064] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A removable parathyroid blood supply detection kit, comprising a housing (1), wherein the housing (1) has an openable lid (2) on its top, characterized in that, The housing (1) is provided with a developer injection mechanism (3), a drug injection mechanism (4) and a three-way connection mechanism (5). The first end of the three-way connection mechanism (5) is connected to the developer injection mechanism (3), the second end is connected to the drug injection mechanism (4), and the third end is used to connect to the indwelling needle. The three-way connection mechanism (5) can switch between the developer injection function and the reagent injection function. The three-way connection mechanism (5) is not simultaneously connected to the developer injection mechanism (3) and the drug injection mechanism (4). The three-way connection mechanism (5) includes a liquid outlet (51), a developer inlet (52), and a reagent inlet (53); the liquid outlet (51) is connected to the developer inlet (52), or the liquid outlet (51) is connected to the reagent inlet (53); The three-way connection mechanism (5) also includes an outer shell (50), which is disposed inside the box (1). The outer shell (50) has the liquid outlet (51), the developer inlet (52), and the reagent inlet (53) on it. The outer shell (50) is provided with a three-way tube (54). The first end of the three-way tube (54) is connected to the liquid outlet (51), the second end is connected to the developer inlet (52), and the third end is connected to the reagent inlet (53). A flow-blocking device (55) is provided at the intersection of the three ends of the three-way tube (54). The flow-blocking device (55) is used to block the second end or the third end of the three-way tube (54) so ​​that the reagent kit can switch between the developer injection function and the reagent injection function. The flow-blocking device (55) includes a rotating shaft (551) and a flow-blocking plate (552). The rotating shaft (551) is installed at the intersection of the three ends of the three-way pipe (54). The flow-blocking plate (552) is connected to the rotating shaft (551) along its axial direction. The flow-blocking plate (552) contacts the inner wall of the three-way pipe (54) and can, together with the rotating shaft (551), block one liquid flow passage of the developer inlet (52) or the reagent inlet (53). The rotating shaft (551) is provided with a drive device to control its rotation.

2. The detachable parathyroid blood supply detection kit according to claim 1, characterized in that, The top surface and one side of the box body (1) are open, and the lid (2) has a shielding surface (21) on the same side as the open side of the box body (1).

3. The detachable parathyroid blood supply detection kit according to claim 1, characterized in that, The driving device is a handle, the rotating shaft (551) passes through the outer shell (50) and the three-way pipe (54), and a sealing device is provided at the connection of the three. The part of the rotating shaft (551) located outside the outer shell (50) is connected to the handle. Alternatively, the driving device may be a controller, and the flow-blocking device (55) may further include a first float (553) and a second float; The first float (553) is located on the side of the intercepting plate (552) near the developer inlet (52). The intercepting plate (552) is provided with a first pressure sensor (5521) that can contact the first float (553). A first elastic rope (5531) is provided around the outer periphery of the first float (553), and a first arc frame (5532) is provided around the outer periphery of the first elastic rope (5531). When there is no liquid flow, the first float (553) is separated from the first pressure sensor (5521). Under the impact force of the liquid, the first float (553) contacts the first pressure sensor (5521), and the first pressure sensor (5521) generates a pressure signal. The second float is located on the side of the intercepting plate (552) near the drug inlet (53). The intercepting plate (552) is provided with a second pressure sensor (5522) that can contact the second float. A second elastic rope is provided around the outer periphery of the second float, and a second arc frame is provided around the outer periphery of the second elastic rope. When there is no liquid flow, the second float is separated from the second pressure sensor (5522). Under the impact force of the liquid, the second float contacts the second pressure sensor (5522), and the second pressure sensor (5522) generates a pressure signal.

4. The detachable parathyroid blood supply detection kit according to claim 3, characterized in that, The developer injection mechanism (3) includes a first injection cylinder (31) and a first power unit. The front end of the first injection cylinder (31) is provided with a first connecting pipe (32), and the first connecting pipe (32) is detachably connected to the developer inlet (52). The structure of the drug injection mechanism (4) is the same as that of the developer injection mechanism (3).

5. The detachable parathyroid blood supply detection kit according to claim 4, characterized in that, The first power device is a peristaltic pump; Alternatively, the first power device is a telescopic motor (34), and the tail end of the first injection cylinder (31) is provided with the front end of a push rod (33). The tail end of the push rod (33) is connected to the telescopic end of the telescopic motor (34), and the fixed end of the telescopic motor (34) is installed on the side wall of the box (1) opposite to its side opening.

6. The removable parathyroid blood supply detection kit according to claim 5, characterized in that, The inner wall of the box (1) is also provided with a control panel, which is provided with multiple working switches. The multiple working switches are respectively used to control the first power device and the second power device. The controller is electrically connected to the first pressure sensor (5521), the second pressure sensor (5522), the first power device, the second power device, the power supply and the control panel.

7. The removable parathyroid blood supply detection kit according to claim 1, characterized in that, A support plate (11) is longitudinally arranged on one side of the box body (1) near its side opening. The support plate (11) is provided with a first bayonet (111) and a second bayonet (112). The first bayonet (111) is connected to the developer injection mechanism (3), and the second bayonet (112) is connected to the drug injection mechanism (4). The three-way connecting mechanism (5) is located between the side opening of the box body (1) and the support plate (11).

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