A hybrid particle scanning irradiation method and system

Abstract

The present application discloses a hybrid particle scanning irradiation method and system, which relate to the technical field of high-speed particle beam experiments. The hybrid particle scanning irradiation method includes the following steps: obtaining target medium area information, target medium total dose information and a scanning judgment model; dividing the target medium area into sub-areas based on the target medium area information; allocating doses to each of the sub-areas based on the target medium total equivalent information; distinguishing and judging the sub-areas; if the sub-areas are continuously scanned, a continuous scanning mode is applied; if the sub-areas are point scanning, a point scanning mode is applied; the combination of point scanning and continuous scanning effectively reduces the number of times the beam is switched on and off, thereby reducing the leakage dose when the beam is turned off, improving the accuracy of the experimental results, and ensuring uniform irradiation of the entire target medium area.

Description

Technical Field

[0001] The present application relates to the field of high-speed particle beam experiments, and in particular to a hybrid particle scanning irradiation method and system. Background Art

[0002] Particles refer to electrons, protons, neutrons and other positively or negatively charged ions. With the continuous in-depth research on high-speed particle beams, high-speed particle beams are widely used in many fields such as modern weapons.

[0003] In high-speed particle beam research experiments, a high-speed particle beam is used to bombard a target medium to observe its response. This is typically accomplished using spot scanning irradiation. Specifically, the target medium is divided into regions and a predetermined dose is assigned to each region. When the predetermined dose is delivered to a specific point, the scanning control device receives a dose arrival signal from the dose monitor, and the beam emission control device terminates beam emission based on a point switching instruction. Simultaneously, the electromagnetic power supply, which provides the excitation current to the scanning electromagnets that scan the particle beam, begins setting the current value corresponding to the coordinates of the next irradiation point. Upon receiving a signal from the electromagnetic power supply that completes the current setting, the scanning irradiation device outputs a beam start command to the beam emission control device, initiating irradiation of the next point. This process is repeated until every region of the target medium has been irradiated.

[0004] In experiments, a target medium is often divided into many areas. Every time the scanning point is changed, the beam emission control device needs to be turned on and off, which seriously affects the efficiency of the scanning test. At the same time, during actual experimental operation, even if the beam emission control device outputs a beam termination instruction, the beam emission cannot actually be terminated immediately, and a certain degree of delay error will occur. Therefore, when the irradiation position is moved, a leakage dose will appear at the current irradiation point. When the set irradiation dose for each point is very small, the leakage dose / set dose will be very large, which seriously affects the accuracy of the experimental results. To prevent this problem, the beam intensity needs to be reduced so that the proportion of leakage dose is relatively small. However, the reduction in beam intensity will lead to an increase in experimental time.

[0005] Therefore, there is room for improvement in the point scanning irradiation method in high-speed particle beam experiments. Summary of the Invention

[0006] In order to address the technical problems that the point scanning method used in particle beam experiments leads to low experimental efficiency and large errors in experimental results, the first purpose of this application is to provide a hybrid particle scanning irradiation method. By combining point scanning with continuous scanning, the number of times the particle beam is switched on and off is greatly reduced, thereby effectively improving the experimental efficiency. Based on the above-mentioned hybrid particle scanning irradiation method, the second purpose of this application is to protect a hybrid particle scanning system.

[0007] The hybrid particle scanning irradiation method provided in this application adopts the following technical solution:

[0008] A hybrid particle scanning irradiation method comprises the following steps:

[0009] Obtaining target medium area information, target medium total dose information, and a scanning judgment model;

[0010] Dividing the target medium area into sub-areas based on the target medium area information;

[0011] allocating a dose to each of the sub-areas based on the total equivalent information of the target medium;

[0012] P1: Irradiate the current sub-region with a set dose of particle beam. Based on the set scanning judgment model, determine whether the dose allocated to the next sub-region is a continuous scanning sub-region. If yes, proceed to P2; otherwise, proceed to P3. When all sub-regions are irradiated, the cycle ends.

[0013] P2, keep the particle emission state, move the particle irradiation head to the next sub-area, and return to P1;

[0014] P3. Turn off the particle beam, move the particle irradiation head to the next sub-area, turn on the particle beam, and return to P1.

[0015] By adopting the above technical solution, the target medium area is first divided into multiple sub-areas, and then the dose corresponding to the sub-area is allocated to each sub-area. If the next scanning area of ​​the current scanning sub-area is a continuous scanning sub-area, the current scanning mode is the continuous scanning mode, that is, the particle emission state is maintained and the particle irradiation head is moved to the next sub-area. If the next scanning area of ​​the current scanning sub-area is not a continuous scanning sub-area, the current scanning mode is the point scanning mode, the particle beam is turned off, the particle irradiation head is moved to the next sub-area, and then the particle beam is turned on for irradiation, which greatly reduces the number of times the particle beam is turned on and off, increases the ratio of irradiation time to operation time, and effectively improves the experimental efficiency. At the same time, by combining point scanning with continuous scanning, the number of times the beam is turned on and off is effectively reduced, thereby reducing the leakage dose when the beam is turned off, reducing the ratio of leakage dose to set dose, and effectively improving the accuracy of the experimental results. Since the total irradiation dose is fixed, the combination of continuous scanning and point scanning ensures uniform irradiation of the entire target medium area.

[0016] Preferably, judging whether the next sub-region allocated dose is a continuous scan sub-region based on the scan determination model includes:

[0017] Dividing the sub-region into a central sub-region and an edge sub-region based on whether the sub-region has complete upper, lower, left, and right adjacent regions;

[0018] When the next sub-region is the central sub-region, the next sub-region is a continuous scanning sub-region.

[0019] By adopting the above technical solution, after the target area is divided into multiple sub-areas, when the sub-area has complete upper, lower, left and right adjacent areas, the sub-area is located at the center of the entire target medium area and is the central sub-area. When the sub-area has only one, two or three adjacent areas, the sub-area is located at the edge of the entire target medium area. Since the sub-area located at the center position must have an adjacent central sub-area, and the area of ​​the sub-area located at the center is larger, it meets the conditions for continuous scanning. Therefore, all central sub-areas are set as continuous scanning sub-areas, which saves judgment time and further improves the efficiency of scanning and irradiation.

[0020] Preferably, judging whether the next sub-region allocated dose is a continuous scan sub-region based on the scan determination model includes:

[0021] Obtain continuous scan determination dose;

[0022] obtaining a dose allocated to the edge sub-region;

[0023] When the dose allocated to the edge sub-region is greater than the continuous scanning determination dose, the edge sub-region is the continuous scanning sub-region;

[0024] When the dose allocated to the edge sub-region is greater than the dose determined by continuous scanning, the edge sub-region is a point scanning sub-region.

[0025] By adopting the above technical solution, a continuous scanning determination dose is preset, and the continuous scanning determination dose is used to determine whether the dose allocated to the edge sub-area is sufficient to be suitable for the continuous scanning mode. If the dose allocated to the edge sub-area is greater than the continuous scanning determination dose, then although the edge sub-area is located at the edge of the target medium, its area is larger and can be suitable for continuous scanning. If the dose allocated to the edge sub-area is less than or greater than the continuous scanning determination dose, then the edge sub-area can only be suitable for point scanning.

[0026] Preferably, obtaining the continuous scanning determination dose includes:

[0027] Obtaining the current beam intensity data, the distance data between adjacent sub-area irradiation points, and the moving speed data of the particle irradiation head;

[0028] The continuous scanning determination dose is acquired based on the current beam intensity data, the distance data between adjacent sub-area irradiation points, and the moving speed data of the particle irradiation head.

[0029] By adopting the above technical solution, the continuous scanning determination dose is the dose received by the target medium when the particle irradiation head maintains the particle emission state and moves from one sub-area to another. The preset continuous scanning determination dose is changed to be obtained based on the current beam intensity data, the distance data between the irradiation points of adjacent sub-areas, and the movement speed data of the particle irradiation head. The determination result will be more accurate, so that more sub-areas with larger areas can be applied to the continuous scanning mode, further improving the experimental efficiency.

[0030] Preferably, irradiating the current sub-region with a particle beam of a set dose comprises:

[0031] When the current sub-region is the first sub-region or the point scanning sub-region, the set dose is the dose allocated to the first sub-region or the point scanning sub-region;

[0032] When the current sub-region is a continuous scanning sub-region, the set dose is the difference between the dose allocated to the continuous scanning sub-region and the continuous scanning determination dose.

[0033] By adopting the above technical solution, the point scanning sub-area and the first scanning sub-area are also irradiated according to their assigned doses. When scanning a continuously scanning sub-area with a larger area, the assigned dose is deducted from the dose consumed when moving between sub-areas, effectively ensuring that the total dose received by the target medium is constant, effectively reducing experimental errors.

[0034] Preferably, the target medium region information includes target medium region area data and target medium region shape data;

[0035] The dividing the target medium area into sub-areas based on the target medium area information includes:

[0036] Obtain sub-region division model and particle beam size data;

[0037] Based on the target medium region area data, the target medium region shape data and the particle beam size data, the target medium region is divided into a plurality of sub-regions according to the sub-region division model.

[0038] By adopting the above technical solution, the particles are divided into as many continuous scanning sub-areas as possible according to the beam size data, namely the beam width, the shape and area of ​​the target medium, so that the ratio of continuous scanning sub-areas to all sub-areas in the entire target medium area is improved, so that more sub-areas can be applied to the continuous scanning mode, further reducing the time of switching the beam during point scanning, improving the efficiency of the experiment, and reducing the experimental error.

[0039] Preferably, the sub-region information includes sub-region position data, a dose allocated to the sub-region, and whether an adjacent region of the sub-region is the continuously scanned sub-region (1);

[0040] The hybrid particle scanning irradiation method further includes obtaining a scanning path based on sub-region related information, including:

[0041] Get the path planning model;

[0042] Based on the sub-region position data, the dose allocated to the sub-region, and whether an adjacent region of the sub-region is the continuously scanned sub-region, a scanning path of the current target medium region is acquired according to the path planning model.

[0043] By adopting the above technical solution, the scanning path with the shortest time is obtained based on the information related to the sub-areas, so that the efficiency of the entire hybrid scanning irradiation is further improved. All continuously scanned sub-areas are connected together and continuously scanned as a whole according to the set dose. The starting and end points of the overall scan are planned according to the position and number of the point scanning sub-areas, and the scanning path with the shortest time is planned.

[0044] Preferably, allocating the dose to each of the sub-areas based on the target medium total dose information includes:

[0045] Get sub-region area data;

[0046] Obtaining a dose distribution model;

[0047] Based on the target medium total dose information, the sub-region area data and the target medium region area data, a dose is distributed to each sub-region according to the dose distribution model.

[0048] By adopting the above technical solution, the dose can be evenly distributed according to the area of ​​each divided sub-region, so that the entire target medium can be evenly irradiated, thereby improving the accuracy of the experiment.

[0049] A hybrid particle scanning irradiation system includes a particle irradiation head for emitting a high-speed particle beam, a motion device for controlling the movement of the particle therapy head, and a detection device for detecting the dose received by the current area; and further includes:

[0050] An information acquisition unit, used to acquire target medium area information and target medium total dose information;

[0051] an information storage unit, data-connected to the information acquisition unit and the information processing unit, storing a sub-region division model, a dose distribution model, and a scanning determination model;

[0052] an information processing unit, data-connected to the information acquisition unit, for dividing the sub-regions, allocating doses to the sub-regions, and determining whether the next sub-region is a continuously scanned sub-region;

[0053] The execution unit includes a controller, which outputs a control signal to the particle therapy head to control the on / off state of the particle therapy head.

[0054] By adopting the above technical solution, the information acquisition unit can receive and obtain the target medium area information and total dose information, and transmit it to the information processing unit. The information processing unit calls the various models stored in the information processing unit to perform optimal area division, dose distribution, and scanning mode determination, and outputs the area division results, dose distribution results, and scanning mode determination results to the execution unit. The controller of the execution unit controls the particle therapy head to scan according to the determined scanning mode. Through the above settings, the hybrid particle scanning irradiation system can effectively shorten the time for scanning and irradiating the target medium area of ​​the same area, thereby improving the experimental efficiency.

[0055] Preferably, the information processing unit includes:

[0056] A sub-region division module, configured to divide the target medium region into a plurality of sub-regions according to the sub-region division model;

[0057] A dosage distribution module, configured to distribute the total dosage of the target medium to each sub-area distribution dosage according to the dosage distribution model;

[0058] The scanning determination module is used to determine whether the sub-region is a continuous scanning sub-region according to the scanning determination model.

[0059] By adopting the above technical solution, the sub-area division module divides the target medium area into the most favorable parts for continuous scanning according to the sub-area division model in the information storage unit, the dose distribution module distributes doses uniformly to the sub-areas according to the dose distribution model in the information storage unit, and the scanning judgment model divides the sub-areas into continuous scanning sub-areas and point scanning sub-areas according to the scanning judgment model in the information storage unit.

[0060] Preferably, the information storage unit further stores a path planning model;

[0061] The information processing unit further includes a path planning module for generating scanning path data according to the path planning model. The controller receives and outputs a control signal to the motion device in response to the scanning path data to control the motion trajectory of the particle irradiation head.

[0062] By adopting the above technical solution, the path planning module plans the shortest scanning path according to the path planning model stored in the information storage unit, and outputs the planning result to the controller. The controller controls the motion device to make the particle irradiation head move according to the predetermined trajectory.

[0063] In summary, this application includes at least one of the following beneficial technical effects:

[0064] 1. By combining point scanning with continuous scanning, the number of times the particle beam is switched on and off is greatly reduced, the ratio of irradiation time to operation time is increased, and the experimental efficiency is effectively improved;

[0065] 2. By combining point scanning with continuous scanning, the number of times the beam is switched on and off is effectively reduced, thereby reducing the leakage dose when the beam is turned off, lowering the ratio of leakage dose to set dose, and effectively improving the accuracy of the experimental results;

[0066] 3. Since the total irradiation dose is fixed, the combination of continuous scanning and point scanning ensures uniform irradiation of the entire target medium area;

[0067] 4. Through double scanning judgment of sub-areas, precise division of point scanning sub-areas and continuous scanning sub-areas is carried out, effectively and accurately determining when continuous scanning mode is applicable;

[0068] 5. By adaptively adjusting the irradiation dose of different sub-areas, when scanning a large continuous scanning sub-area, the dose consumed when moving between sub-areas is deducted from the allocated dose, effectively ensuring that the total dose received by the target medium is constant, effectively reducing experimental errors;

[0069] 6. By planning the scanning path based on sub-region related information before scanning, a scanning path with shorter time consumption and more uniform irradiation results is planned, which further improves the experimental efficiency and the accuracy of the experimental results. BRIEF DESCRIPTION OF THE DRAWINGS

[0070] Figure 1 This is an operational flow chart of Example 1 of the present application;

[0071] Figure 2 This is a schematic diagram of the steps of Example 1 of the present application;

[0072] Figure 3 Schematic diagram of target medium area A in Example 1 of the present application;

[0073] Figure 4 This is a schematic diagram of the target medium area A divided into sub-areas in the first embodiment of the present application;

[0074] Figure 5 Schematic diagram of the scanning path of target medium area A in the first embodiment of the present application;

[0075] Figure 6 1 is a schematic diagram of the determination result of the target medium area A in the first embodiment of the present application;

[0076] Figure 7 This is a schematic diagram of the scanning determination process of Example 1 of the present application;

[0077] Figure 8 This is a module schematic diagram of a hybrid particle scanning and irradiation system according to Example 1 of the present application;

[0078] Figure 9 This is a schematic diagram of the steps of Example 2 of the present application;

[0079] Figure 10 Schematic diagram of the scanning path of target medium area A in the second embodiment of the present application;

[0080] Figure 11 This is a module schematic diagram of a hybrid particle scanning and irradiation system according to Example 2 of the present application.

[0081] Figure numerals: 1. continuous scanning sub-area; 2. point scanning sub-area; 3. information acquisition unit; 4. information storage unit; 5. information processing unit; 6. execution unit. DETAILED DESCRIPTION

[0082] The following is combined with Figure 1-11 This application is described in further detail.

[0083] Example 1

[0084] The present application embodiment discloses a hybrid particle scanning irradiation method. Figure 1-2 , a hybrid particle scanning irradiation method, comprising the following steps:

[0085] S100: Acquire target medium area information, target medium total dose information, and a scanning determination model.

[0086] Specifically, the target medium area information includes target medium area data and target medium area shape data, such as Figure 3 As shown in the example of this application, a target medium region A with a relatively small area and simple shape is selected for ease of illustration. The area of ​​target medium region A is 5. It should be noted that this area does not have units and does not represent the actual physical area of ​​region A. This area can be manually input or acquired through image recognition. The Canny edge detection algorithm in image recognition is used to extract the outline of target medium region A, perform grayscale processing, and filter it to obtain relatively accurate area data and relatively clear shape data.

[0087] The total dose information of the target medium is the total dose that the target medium needs to receive in this experiment. It is determined by the experimental process and input by the operator. For the sake of convenience, in this embodiment, the total dose of the target medium is also set to 5, that is, the area corresponds to the dose. In the experimental operation, the total dose is not always linearly related to the area.

[0088] The scanning determination model is used to determine whether the current applicable mode is the point scanning mode or the continuous scanning mode. The specific determination method is as described in S400.

[0089] S200: Divide the target medium area into sub-areas based on the target medium area information.

[0090] S200 includes the following steps:

[0091] S201. Obtain a sub-region division model and particle beam size data. The particle beam size data refers to the width of the particle beam, or the diameter of the beam spot at a set distance. A larger particle beam size means a larger area of ​​the target medium will be affected when the particle beam strikes a point on the target medium. This allows a larger area to be divided into sub-regions, resulting in fewer sub-regions. Conversely, a smaller particle beam size increases the number of sub-regions.

[0092] S202 : Based on the target medium region area data, the target medium region shape data, and the particle beam size data, the target medium region is divided into a plurality of sub-regions according to the sub-region division model.

[0093] According to the size of the particle beam, the area of ​​the target medium area, and the shape of the target medium, the target medium area is divided into multiple sub-areas. The role of the shape in the embodiment of the present application is that each sub-area needs to be divided into regular or irregular convex shapes as much as possible. At the same time, the divided sub-areas need to be concentrated as much as possible to avoid the appearance of long strip-shaped sub-areas, which facilitates subsequent scanning model judgment and scanning.

[0094] In the embodiments of this application, Figure 4 As shown, the target medium area A is divided into five sub-areas, namely A1, A2, A3, A4, and A5, according to the sub-area division model. The sum of the areas of the five sub-areas is 5, and the areas of the sub-areas are S1, S2, S3, S4, and S5 respectively.

[0095] S300 : Allocate dosage to each of the sub-areas based on the total equivalent information of the target medium.

[0096] S300 includes the following steps:

[0097] S301 , obtaining sub-region area data, that is, the areas S1 , S2 , S3 , S4 , and S5 of each sub-region.

[0098] S302: Obtain a dose distribution model.

[0099] S303: Based on the target medium total equivalent information, the sub-region area data, and the target medium region area data, a dose is allocated to each sub-region according to the metering distribution model. The dose allocated to each sub-region is proportional to its area. In the embodiment of the present application, the areas of each sub-region are D1, D2, D3, D4, and D5, and the sum of the areas is the total dose D.

[0100] S400, P1, irradiate the current sub-region with a set dose of particle beam, and determine whether the dose allocated to the next sub-region is a continuous scan sub-region 1 based on the set scan judgment model. If yes, proceed to P2, otherwise proceed to P3. When all sub-regions are irradiated, the cycle ends;

[0101] P2, keep the particle emission state, move the particle irradiation head to the next sub-area, and return to P1;

[0102] P3. Turn off the particle beam, move the particle irradiation head to the next sub-area, turn on the particle beam, and return to P1.

[0103] In the embodiment of the present application, the working mode of the particle irradiation head is a scanning mode determination while irradiating and determining the next sub-area, that is, the scanning path is fixed, such as Figure 5 As shown, one scanning path is A1 to A2 to A3 to A5 to A4.

[0104] During the scanning process, two sub-region judgments are performed, such as Figure 7 As shown, the steps for determining the first heavy sub-region are:

[0105] S411, based on whether the sub-region has complete upper, lower, left, and right adjacent regions, the sub-region is divided into a central sub-region and an edge sub-region.

[0106] S412. When the next sub-region is a central sub-region, the next sub-region is continuous scanning sub-region 1. When a sub-region has complete upper, lower, left, and right adjacent regions, the sub-region is located at the center of the entire target medium area and is a central sub-region. Since a sub-region located at the center must have an adjacent central sub-region, and the sub-region located at the center is large in area, it meets the conditions for continuous scanning. Therefore, all central sub-regions are set as continuous scanning sub-region 1, saving judgment time and further improving the efficiency of scanning and irradiation. When a sub-region has only one, two, or three adjacent regions, that is, it does not have complete upper, lower, left, and right adjacent sub-regions, the sub-region is located at the edge of the entire target medium area. For example, the five sub-regions in the embodiment of the present application do not have complete adjacent sub-regions and are all edge sub-regions.

[0107] The steps for the second level of judgment are:

[0108] S421. Obtain a continuous scanning determination dose. The continuous scanning determination dose is the dose received by the target medium when the particle irradiation head maintains a particle emission state and moves from one sub-region to another. It is determined by the current beam intensity data, the distance data between irradiation points in adjacent sub-regions, and the movement speed data of the particle irradiation head. In this embodiment of the present application, the continuous scanning determination dose is Dt, which is calculated using the above data.

[0109] S422: Obtain the dose allocated to the edge sub-region.

[0110] S423: When the dose allocated to the edge sub-region is greater than the continuous scanning determination dose, the edge sub-region is the continuous scanning sub-region 1.

[0111] S424 : When the dose allocated to the edge sub-region is greater than the continuous scanning determination dose, the edge sub-region is designated as point scanning sub-region 2 .

[0112] If continuous scanning is used for a small-dose sub-area, when the particle irradiation head moves to the small-dose sub-area, irradiating the sub-area will cause the overall dose to exceed the standard. Failure to irradiate the sub-area will cause the overall dose distribution of the target medium to be uneven. Therefore, the small-dose area is not suitable for the continuous scanning mode. The continuous scanning determination dose is used to determine whether the dose allocated to the edge sub-area is sufficient for the continuous scanning mode. If the dose allocated to the edge sub-area is greater than the continuous scanning determination dose, although the edge sub-area is located at the edge of the target medium, its area is larger and can be used for continuous scanning. If the dose allocated to the edge sub-area is less than or equal to the continuous scanning determination dose, the edge sub-area can only be used for point scanning.

[0113] In the embodiment of the present application, after judgment and comparison, the doses D1, D2, D4, and D5 of A1, A2, A4, and A5 are all greater than the continuous scanning determination dose Dt. A1, A2, A4, and A5 are continuous scanning sub-area 1, and the dose D3 allocated to A3 is less than the continuous scanning determination dose Dt. A3 is a point scanning sub-area 2. Figure 6 shown.

[0114] To further ensure a constant total dose to the target medium, when irradiating the first sub-area of ​​the scanning path or point scanning sub-area 2, the dose irradiated there is the dose allocated to the first sub-area or point scanning sub-area 2. When the currently irradiated sub-area is continuous scanning sub-area 1, the dose irradiated there is the difference between the dose allocated to continuous scanning sub-area 1 and the continuous scanning determination dose. The dose consumed when moving between sub-areas is deducted from the allocated dose, effectively ensuring the uniformity of the dose received by the target medium and reducing experimental errors.

[0115] According to the workflow in step S400, the particle irradiation head moves along the scanning path A1 to A2 to A3 to A5 to A4. The workflow of the embodiment of the present application is as follows:

[0116] The first step is to irradiate the sub-area A1 with a dose of D1, and at the same time determine that the sub-area A2 is a continuous scan sub-area 1;

[0117] Step 2: Keep the particle irradiation head turned on and move it to sub-area A2, irradiate sub-area A2 with a dose of D2-Dt, and at the same time determine that sub-area A3 is a point scanning sub-area 2;

[0118] Step 3: After irradiating sub-area A2, the particle irradiation head is turned off, moved to sub-area A3, and then turned on to irradiate sub-area A3. During the irradiation, sub-area A4 is determined to be a continuous scan sub-area 1.

[0119] Step 4: Keep the particle irradiation head turned on and move it to sub-area A4, irradiate sub-area A4 with a dose of D4-Dt, and determine that sub-area A4 is a point scanning sub-area 2 during irradiation;

[0120] Step 5: Keep the particle irradiation head turned on and move it to sub-area A5, irradiate sub-area A5 with a dose of D5-Dt. After all areas are irradiated, turn off the particle irradiation head.

[0121] A hybrid particle scanning irradiation system, such as Figure 8 As shown, it includes a particle irradiation head for emitting a high-speed particle beam, a motion device for controlling the movement of the particle therapy head, and a detection device for detecting the dosage received in the current area; it also includes an information acquisition unit 3 for obtaining target medium area information and target medium total dosage information, an information storage unit 4 storing a sub-area division model, a dosage distribution model, and a scanning determination model, an information processing unit 5 for dividing sub-areas, distributing dosages to each sub-area, and determining whether the next sub-area is a continuously scanned sub-area 1, and an execution unit 6 for controlling the on / off state of the particle therapy head.

[0122] Among them, the information acquisition unit 3 is data-connected with the information processing unit 5, receives and obtains the target medium area information and total dose information, and transmits it to the information processing unit 5. The information processing unit 5 calls the various models stored in the information processing unit 5 to perform optimal area division, dose distribution, and scanning mode determination, and outputs the area division results, dose distribution results, and scanning mode determination results to the execution unit 6. The execution unit 6 controls the particle therapy head to scan according to the determined scanning mode.

[0123] The information acquisition unit 3 includes a data communication component for acquiring the total dose of the target area, an identification and detection component for acquiring the area data and shape data of the target medium area, and a dose detection component for detecting the dose received by the target medium.

[0124] The information processing unit 5 includes a sub-area division module, a dose distribution module and a scanning judgment module. The sub-area division module divides the target medium area into multiple sub-areas according to the sub-area division model. The dose distribution module distributes the total dose of the target medium to each sub-area distribution dose according to the dose distribution model. The scanning judgment module determines whether the sub-area is a continuous scanning area according to the scanning judgment model.

[0125] In the embodiment of the present application, the information processing unit 5 can be configured as an FPGA module or a single-chip microcomputer module or a customized DSP chip module with a built-in setting program.

[0126] The execution unit 6 includes a controller, which is connected to the particle irradiation head and outputs a control signal to the particle irradiation head to control the on / off state of the particle therapy head.

[0127] Example 2

[0128] A hybrid particle scanning irradiation method, such as Figure 9 As shown, the following steps are included:

[0129] S100: Acquire target medium area information, target medium total dose information, and a scanning determination model.

[0130] S200: Divide the target medium area into sub-areas based on the target medium area information.

[0131] S300 : Allocate dosage to each of the sub-areas based on the total equivalent information of the target medium.

[0132] S400: Obtain a scanning path based on sub-region related information, including sub-region position data, a dose allocated to the sub-region, and whether an adjacent region of the sub-region is the continuous scanning sub-region 1;

[0133] Step 400 includes the following steps:

[0134] S401, obtaining a path planning model. The path planning model in this embodiment exhaustively simulates all possible paths, records the time consumed, and selects the path with the shortest time consumption. Other path planning algorithms can also be used as long as they can simulate a scanning path with the shortest time consumption.

[0135] S402 : Based on the sub-region position data, the dose allocated to the sub-region, and whether the adjacent region of the sub-region is the continuous scanning sub-region 1 , obtain a scanning path for the current target medium region according to the path planning model.

[0136] Through the above steps, all the continuous scanning sub-areas 1 are connected together and continuously scanned as a whole according to the set dose. The starting point and end point of the overall scan are planned according to the position and number of the point scanning sub-areas 2, and the scanning path with the shortest time is planned. In the embodiment of the present application, A1, A2, A4, and A5 in Example 1 are all continuous scanning sub-areas 1, so they are scanned as a whole. A3 is the point scanning sub-area 2, so the final planned scanning route is A1 to A5 to A4 to A2 to A3.

[0137] In the embodiment of the present application, only one point scans sub-area 2, and the time consumption difference between performing path planning and not performing path planning is not obvious. In actual applications, a target medium area can be divided into more sub-areas. In this case, performing optimal path planning can effectively reduce experimental time and improve experimental efficiency.

[0138] S500, P1, irradiate the current sub-region with a set dose of particle beam, and determine whether the dose allocated to the next sub-region is a continuous scan sub-region 1 based on the set scan judgment model. If yes, proceed to P2, otherwise proceed to P3. When all sub-regions are irradiated, the cycle ends;

[0139] P2, keep the particle emission state, move the particle irradiation head to the next sub-area, and return to P1;

[0140] P3. Turn off the particle beam, move the particle irradiation head to the next sub-area, turn on the particle beam, and return to P1.

[0141] The difference from Example 1 is that it also includes step S400, which first plans a scanning path based on the sub-region related information. After obtaining the scanning path, subsequent scanning and irradiation are performed according to the planned path. In this embodiment of the present application, the path planning can also directly obtain the distance between the center points of each sub-region, so that a different and more accurate Dt can be calculated, making the measurement of the irradiation of each consecutive scan sub-region 1 more accurate.

[0142] The workflow of the embodiment of this application is as follows:

[0143] The first step is to obtain relevant information and plan the scanning path.

[0144] The second step is to perform scanning and irradiation according to the planned path and predetermined pattern.

[0145] A hybrid particle scanning irradiation system, such as Figure 11 As shown, the difference from the embodiment is that the information storage unit 4 also stores a path planning model, and the information processing unit 5 also includes a path planning module for generating scanning path data according to the path planning model. The controller receives and responds to the scanning path data, outputs a control signal to the motion device to control the motion trajectory of the particle irradiation head, and realizes scanning irradiation according to the planned route.

[0146] The above description is merely a preferred embodiment of the present application. The scope of protection of the present application is not limited to the above embodiments. All technical solutions based on the concept of the present application are within the scope of protection of the present application. It should be noted that for those skilled in the art, certain improvements and modifications that do not depart from the principles of the present application should also be considered within the scope of protection of the present application.

Claims

1. A hybrid particle scanning irradiation method, characterized in that: The following steps are involved: Obtaining target medium area information, target medium total dose information, and a scanning judgment model; Dividing the target medium area into sub-areas based on the target medium area information; allocating a dose to each of the sub-areas based on the total equivalent information of the target medium; P1, irradiate the current sub-region with a set dose of particle beam, and judge whether the dose allocated to the next sub-region is a continuous scanning sub-region (1) based on the set scanning judgment model. If yes, proceed to P2, otherwise proceed to P3. When all sub-regions are irradiated, the cycle ends; P2, keep the particle emission state, move the particle irradiation head to the next sub-area, and return to P1; P3, turn off the particle beam, move the particle irradiation head to the next sub-area, turn on the particle beam, and return to P1; Determining whether the next sub-region allocated dose is a continuous scan sub-region based on the scan determination model (1) includes: Dividing the sub-region into a central sub-region and an edge sub-region based on whether the sub-region has complete upper, lower, left, and right adjacent regions; When the next sub-region is a central sub-region, the next sub-region is a continuous scanning sub-region (1); obtaining a dose allocated to the edge sub-region; When the dose allocated to the edge sub-region is greater than the continuous scanning determination dose, the edge sub-region is a continuous scanning sub-region (1); When the dose allocated to the edge sub-region is less than the dose determined by continuous scanning, the edge sub-region is a point scanning sub-region (2).

2. A hybrid particle scanning irradiation method according to claim 1, characterized in that: The obtaining of the continuous scanning determination dose comprises: Obtaining the current beam intensity data, the distance data between adjacent sub-area irradiation points, and the moving speed data of the particle irradiation head; The continuous scanning determination dose is acquired based on the current beam intensity data, the distance data between adjacent sub-area irradiation points, and the moving speed data of the particle irradiation head.

3. The hybrid particle scanning irradiation method according to claim 1, characterized in that: The particle beam irradiating the current sub-area with a set dose includes: When the current sub-region is the first sub-region or the point scanning sub-region (2), the set dose is the dose allocated to the first sub-region or the point scanning sub-region (2); When the current sub-region is the continuous scanning sub-region (1), the set dose is the difference between the dose allocated to the continuous scanning sub-region (1) and the continuous scanning determination dose.

4. The hybrid particle scanning irradiation method according to claim 1, characterized in that: The target medium region information includes target medium region area data and target medium region shape data; The dividing the target medium area into sub-areas based on the target medium area information includes: Obtain sub-region division model and particle beam size data; Based on the target medium region area data, the target medium region shape data and the particle beam size data, the target medium region is divided into a plurality of sub-regions according to the sub-region division model.

5. The hybrid particle scanning irradiation method according to claim 1, characterized in that: The sub-region information includes sub-region position data, the dose allocated to the sub-region, and whether the adjacent region of the sub-region is the continuously scanned sub-region (1); The hybrid particle scanning irradiation method further includes obtaining a scanning path based on sub-region related information, including: Get the path planning model; Based on the sub-region position data, the dose allocated to the sub-region, and whether the adjacent region of the sub-region is the continuous scanning sub-region (1), the scanning path of the current target medium region is obtained according to the path planning model.

6. The hybrid particle scanning irradiation method according to claim 4, characterized in that: The allocating doses to the sub-areas based on the target medium total equivalent information includes: Get sub-region area data; Obtaining a dose distribution model; Based on the target medium total equivalent information, the sub-region area data and the target medium region area data, a dose is distributed to each sub-region according to the dose distribution model.

7. A hybrid particle scanning irradiation system for implementing a hybrid particle scanning irradiation method according to any one of claims 1 to 6, comprising a particle irradiation head for emitting a high-speed particle beam, a motion device for controlling the movement of the particle therapy head, and a detection device for detecting the dose received by the current area; characterized in that: Also includes: An information acquisition unit (3) is used to acquire target medium area information and target medium total dose information; An information storage unit (4) is data-connected to the information acquisition unit (3) and the information processing unit (5), and stores a sub-region division model, a dose distribution model, and a scanning determination model; An information processing unit (5) is data-connected to the information acquisition unit (3) and is used to divide the sub-regions, allocate doses to each sub-region, and determine whether the next sub-region is a continuous scanning sub-region (1); The execution unit (6) includes a controller, which outputs a control signal to the particle irradiation head to control the on / off state of the particle therapy head.

8. The hybrid particle scanning irradiation system according to claim 7, characterized in that: The information processing unit (5) comprises: A sub-region division module, configured to divide the target medium region into a plurality of sub-regions according to the sub-region division model; A dosage distribution module, configured to distribute the total dosage of the target medium to each sub-area distribution dosage according to the dosage distribution model; A scanning determination module is used to determine whether a sub-region is a continuous scanning sub-region (1) according to the scanning determination model.

9. The hybrid particle scanning irradiation system according to claim 8, characterized in that: The information storage unit (4) also stores a path planning model; The information processing unit (5) further comprises a path planning module for generating scanning path data according to the path planning model; the controller receives and outputs a control signal to the motion device in response to the scanning path data to control the motion trajectory of the particle irradiation head.

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