Anti-rotation transmission mechanism of a tissue fixation device and tissue fixation device

Abstract

The application provides a rotation prevention transmission mechanism of a tissue fixing device and the tissue fixing device, which comprises a supporting mechanism, a clutch mechanism and a rotation prevention locking assembly. The supporting mechanism comprises a fixed connection assembly and a driving assembly which is threadedly matched with the fixed connection assembly to realize relative axial movement. The rotation prevention locking assembly comprises a locking biasing member and a locking member. The locking biasing member provides a biasing force to the locking member towards the driving assembly. The driving assembly is provided with a rotation prevention locking opening. The rotation prevention locking assembly is arranged such that when the driving assembly is in a separated state from the operating rod and moves to a preset area relative to the fixed connection assembly, the locking member is pressed into the rotation prevention locking opening by the locking biasing member to limit the rotation of the driving assembly relative to the fixed connection assembly. By arranging the rotation prevention locking assembly, the rotation of the driving assembly is limited by the locking member in the case that the driving assembly is separated from the operating rod, stable locking is realized after the valve clamping instrument completes clamping, and relative rotation of the transmission rod is avoided to affect the clamping stability.

Description

Technical Field

[0001] This invention relates to medical devices, and more particularly to an anti-rotation transmission mechanism and a tissue fixation device for a tissue fixation apparatus. Background Technology

[0002] The most common treatment for mitral regurgitation relies on artificial valve replacement and valve repair techniques, such as rectangular resection of the posterior leaflet, chordae tendineae folding, edge-to-edge repair, artificial chordae tendineae implantation, and replacement and repair. These techniques usually rely on open cardiac surgery, in which the patient's chest is typically opened via sternotomy and the patient is placed in a cardiopulmonary shunt.

[0003] Valve clamping instruments, developed based on the principle of surgical valve edge-to-edge suturing, are currently the most recognized due to their high safety, simple technical principle, and great feasibility.

[0004] In existing technologies, the locking of the closure clamp of valve clamping instruments relies on a helical groove to achieve a self-locking principle. For example, application number 202023300828.9 discloses a clamping self-locking component for a tissue fixation device. This component uses a thread helix angle smaller than the friction angle between the base thread and the drive thread. When the base housing or drive shaft is stopped, if only an axial force is applied to the base housing or drive shaft, no axial displacement will occur. Unlike existing technologies, it does not require spring plates or other structures for self-locking and can remain in any position through the threaded engagement. However, under strong vibration, the contact surface may jump, causing the transmission rod to rotate at a certain angle. This results in a corresponding change in the angle of the closure clamp. To avoid this problem, a structure is needed to achieve stable locking after the valve clamping instrument has completed clamping, preventing relative rotation of the transmission rod from affecting clamping stability. Summary of the Invention

[0005] To address the aforementioned technical problems, the present invention provides an anti-rotation transmission mechanism for a tissue fixation device and a tissue fixation device including the mechanism. By setting an anti-rotation locking component, when the drive component is disengaged from the control lever, the locking component restricts the rotation of the drive component, achieving stable locking after the valve clamping instrument completes clamping, thus preventing relative rotation of the transmission lever from affecting clamping stability.

[0006] Specifically, the following options are included:

[0007] An anti-rotation transmission mechanism for a tissue fixation device, comprising:

[0008] The support mechanism includes a fixed connection component and a drive component that is threadedly engaged with the fixed connection component to achieve relative axial movement. The drive component drives the opening and closing of the clamping mechanism of the tissue fixation device by moving axially relative to the fixed connection component.

[0009] The clutch mechanism includes a lever capable of providing driving force to the drive assembly; the lever is axially separable from the drive assembly and is anti-rotationally connected.

[0010] An anti-rotation locking assembly includes a locking biasing element and a locking element, wherein the locking biasing element provides a biasing force to the locking element toward the drive assembly;

[0011] The drive assembly is provided with an anti-rotation locking opening; the anti-rotation locking assembly is configured such that when the drive assembly is separated from the control lever and moves to a preset area relative to the fixed connection assembly, the locking member is pressed into the anti-rotation locking opening by the locking biasing member to restrict the drive assembly from rotating relative to the fixed connection assembly.

[0012] Furthermore, when the locking member is pressed into the anti-rotation locking opening, the locking member is at least partially fixed relative to the circumferential direction of the fixed connection assembly.

[0013] Furthermore, the locking biasing member is located outside the fixed connection assembly, which includes a guide hole, and the locking member is pressed into the anti-rotation locking opening after passing through the guide hole.

[0014] Furthermore, the locking biasing member includes a base and a biasing part, the base being disposed on the fixed connection assembly, and the biasing part corresponding to the position of the guide hole.

[0015] Furthermore, the drive assembly includes a transmission rod clutch end, and the control lever includes a control lever clutch end that is axially separable from and anti-rotationally connected to the transmission rod clutch end;

[0016] The anti-rotation locking opening is located at the clutch end of the transmission rod.

[0017] Furthermore, when the clutch end of the control lever and the clutch end of the transmission lever are not disengaged, the clutch end of the control lever is at least partially located within the anti-rotation locking opening to prevent the locking member from being pressed into the anti-rotation locking opening.

[0018] Furthermore, the fixed connection assembly includes a base housing, the base housing has a base cavity, the base cavity has a base threaded portion, the drive assembly includes a drive shaft, the drive shaft includes a drive threaded portion that mates with the base threaded portion; the locking opening is located at the distal end of the drive threaded portion.

[0019] Furthermore, when the drive assembly moves relative to the fixed connection assembly to the preset area, the locking member is higher than the drive thread portion and lower than the upper end of the locking opening.

[0020] In addition, this application also provides an organization fixation device, including a clamping mechanism and an anti-rotation transmission mechanism as described above.

[0021] Furthermore, the clamping mechanism includes a pair of closing members; when the driving component moves relative to the fixed connection component to the preset area, the opening angle between the pair of closing members is in the range of 0° to 60°.

[0022] As described above, the present invention has the following beneficial effects:

[0023] 1) By setting an anti-rotation locking component, when the drive component is disengaged from the control lever, the locking component restricts the rotation of the drive component, and achieves stable locking after the valve clamping instrument completes clamping, thus preventing relative rotation of the transmission rod from affecting the clamping stability.

[0024] 2) The fixed connection component is provided with a positioning pin. The positioning pin is set in the positioning opening of the fixed connection component and passes through the socket positioning port of the base to position and limit the base, which can effectively prevent the base from rotating relative to the fixed connection component.

[0025] 3) The length of the anti-rotation locking opening ensures that the closing clamp angle is within a certain specific angle range. The locking component will only work when the locking component is pressed against the transmission rod shaft. Since the locking component is pressed against the transmission rod shaft at this time, the locking component will not affect the rotation of the drive component. The operator can still try to re-enter the clutch end of the control lever into the groove of the drive component through the delivery system, rotate the drive component, adjust the closing clamp angle to a suitable position within 60°, and then release it. Attached Figure Description

[0026] To more clearly illustrate the technical solutions of the present invention, the accompanying drawings used in the description of the embodiments or prior art will be briefly introduced below. Obviously, the drawings described below are merely some embodiments of the present invention, and those skilled in the art can obtain other drawings based on these drawings without any creative effort.

[0027] Appendix Figure 1 This is a schematic diagram of the overall structure of an embodiment of this application;

[0028] Appendix Figure 2 for Figure 1 A schematic diagram of the structure after removing part of the shell;

[0029] Appendix Figure 3 This is a schematic diagram of the structure of the closure when it is opened to an obtuse angle, according to an embodiment of this application.

[0030] Appendix Figure 4 This is a schematic diagram of the structure of an embodiment of the present application where the locking element is not locked after the clutch end of the control lever is separated from the clutch end of the transmission rod.

[0031] Appendix Figure 5 This is a schematic diagram of the locking mechanism when the control lever clutch end and the transmission lever clutch end are separated in an embodiment of this application.

[0032] Appendix Figure 6 This is a schematic diagram of the joystick from two perspectives according to an embodiment of this application;

[0033] Appendix Figure 7 This is a schematic diagram of the structure of the driving component in an embodiment of this application;

[0034] Appendix Figure 8 This is a cross-sectional view of the fixed connection component according to an embodiment of this application;

[0035] Appendix Figure 9 This is a schematic diagram of the first type of locking bias member in an embodiment of this application;

[0036] Appendix Figure 10 This is a schematic diagram of the second form of the locking biasing component in an embodiment of this application;

[0037] Appendix Figure 11 (a)-(c) are diagrams showing the three states of the closing element and the capturing element in the embodiments of this application;

[0038] Appendix Figure 12 This is a schematic diagram of the structure of the closure member in an embodiment of this application when the opening angle is 60°;

[0039] Appendix Figure 13 This is a schematic diagram of the structure when the angle between the closing members in an embodiment of this application is 0°. Detailed Implementation

[0040] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. In this embodiment, "proximal end" refers to the direction closer to the operator; "distal end" refers to the direction farther away from the operator. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0041] Example 1:

[0042] See Figure 1-13In this embodiment, the tissue fixation device includes a clamping mechanism 1000 for closing tissue; a support mechanism 2000 for mounting the clamping mechanism 1000; and a clutch mechanism 3000 at the distal end of the support mechanism 2000 for being separably connected to a transport control assembly for transporting and controlling the tissue closure device.

[0043] In conventional tissue fixation devices, taking a heart valve clamping and fixation device as an example, the clamping mechanism 1000 includes a pair of closures 1100 and a pair of catchers 1200 corresponding to each closure 1100. The closures 1100 are opened and closed by a drive assembly 2200, while the catchers 1200 are opened and closed by a control line. When clamping tissue, clamping is achieved through the cooperation of the inner side of the closure 1100 and the outer side of the catcher 1200. The fixation device of this application is delivered to a designated location on the heart via a delivery control assembly, for example, to the mitral valve. After reaching the lesion location, the position where the anterior and posterior leaflets of the heart valve cannot properly align is clamped by the cooperation of the closures 1100 and catchers 1200 of the clamping mechanism 1000 in this embodiment, so that the part that cannot properly align is brought together, thereby allowing the mitral valve to close completely or reducing the opening area, thereby alleviating or treating mitral regurgitation.

[0044] After the mitral valve clamping is completed, the fixation device is then separated from the delivery control component by the clutch mechanism 3000, so that the fixation device remains at the lesion site to keep the valve fixed.

[0045] However, in existing technologies, after the fixing device separates from the conveying control component via a clutch mechanism, it is necessary to ensure the long-term stable clamping of the clamping mechanism. This application specifically addresses tissue fixing devices that achieve clamping via a threaded drive. After tissue clamping is completed, the challenge lies in how to further ensure that the fixing device can continuously and stably clamp the corresponding tissue after the conveying control component separates. This prevents potential vibrations at the contact surface during long-term operation or under strong vibrations, which could cause the transmission rod to rotate at a certain angle, resulting in a corresponding change in the angle of the closing clamp.

[0046] In this embodiment, in order to better explain how the anti-rotation function after separation is achieved, the driving method of the clamping action in this embodiment will be further explained first.

[0047] In this embodiment, the support mechanism 2000 includes a fixed connection component 2100 and a drive component 2200 that can move relative to the fixed connection component 2100. The drive component 2200 includes a drive shaft 2230, which includes a drive thread 2231 that mates with the base thread 2131. Rotational movement exists between the drive output shaft 2210 and the base housing to realize the shaft movement of the drive shaft 2230. The rotation of the drive output shaft 2210 is achieved by applying a torque through the control lever 3100 in the clutch mechanism 3000. Specifically, the clutch end 3120 of the control lever, which is axially separable and anti-relative rotationally connected to the drive component 2200, and the control lever support part 3130 are included.

[0048] The drive assembly 2200 is connected at its distal end to two closure members 1100, so that when the drive assembly 2200 moves relative to the fixed connection assembly 2100, it controls the opening or closing of the closure members 1100; the closure members 1100 cooperate with the gripping member 1200 to clamp tissue. The closure member 1100 includes a guide groove 1130 and a closing connection portion 1120, the closing connection portion 1120 being connected to the distal end of the drive assembly 2200. The fixed connection assembly 2100 is provided with a groove drive member 2150 at least partially located within the guide groove 1130; when the drive assembly 2200 moves relative to the fixed connection assembly 2100, the drive assembly 2200 drives the closing connection portion 1120 to move axially, thus the stationary groove drive member 2150 can slide relative to the guide groove 1130 within the guide groove 1130, thereby driving the two closure members 1100 to move closer or further apart. Figure 11 As shown in (a)-(c).

[0049] In this embodiment, the drive assembly 2200 further includes a transmission rod clutch end 2220, and the control lever clutch end 3120 is connected to the transmission rod clutch end 2220 in an anti-rotational manner. When the tension between the control lever clutch end 3120 and the transmission rod clutch end 2220 is greater than a preset value, the control lever clutch end 3120 disengages from the transmission rod clutch end 2220.

[0050] When it is necessary to separate the control lever clutch end 3120 from the transmission rod clutch end 2220, simply pull the control lever 3100 axially toward the proximal end while keeping the transmission rod clutch end 2220 stationary. The lever will then disengage when the preset value is reached.

[0051] In this embodiment, in order to ensure clamping stability and prevent the drive assembly 2200 from rotating further relative to the fixed connection assembly 2100 after the control lever clutch end 3120 and the transmission lever clutch end 2220 are separated, an anti-rotation locking assembly 4000 is provided. The anti-rotation locking assembly 4000 includes a locking biasing member 4100 and a locking member 4200. The locking biasing member 4100 provides a biasing force toward the driving assembly 2200 to the locking member 4200. Correspondingly, the drive assembly 2200 is provided with an anti-rotation locking opening 2221. The anti-rotation locking assembly 4000 is configured such that when the drive assembly 2200 is separated from the control lever 3100 and moves to a preset area relative to the fixed connection assembly 2100, the locking member 4200 is pressed into the anti-rotation locking opening 2221 by the locking biasing member 4100 to restrict the rotation of the drive assembly 2200 relative to the fixed connection assembly 2100.

[0052] The locking member 4200 restricts the rotation of the drive assembly 2200 relative to the fixed connection assembly 2100. This is achieved by having one part of the locking member 4200 located within the anti-rotation locking opening 2221, while the other part, located outside the anti-rotation locking opening 2221, is fixedly engaged with the fixed connection assembly 2100 circumferentially. Specifically, the locking biasing member 4100 is located outside the fixed connection assembly 2100, which includes a guide hole 2140. The locking member 4200 passes through the guide hole 2140 and is pressed into the anti-rotation locking opening 2221. In other words, the locking member 4200 can slide relative to the fixed connection assembly 2100 within the guide hole 2140, but due to the constraint of the hole, it cannot move axially relative to the fixed connection assembly 2100. When the locking component 4200 passes through the guide hole 2140, one end is inserted into the anti-rotation locking opening 2221, while the remaining part is still located in the guide hole 2140, thereby achieving the effect of restricting the rotation of the drive component 2200 relative to the fixed connection component 2100.

[0053] In other embodiments, the locking member 4200 may also be designed in a way that is circumferentially fixed to the fixed connection component 2100 and can be radially inserted with the anti-rotation locking opening 2221, thereby limiting the rotation of the drive component 2200 relative to the fixed connection component 2100. This will not be elaborated further here.

[0054] Furthermore, in this embodiment, as Figure 9As shown, in order to achieve a stable bias, the locking bias member 4100 includes a base 4110 and a biasing part 4120. The base 4110 is disposed on the fixed connection assembly 2100, and the biasing part 4120 is positioned opposite to the guide hole 2140. The biasing part 4120 is specifically made of an elastic material, preferably an elastic memory material. The original shape of the biasing part 4120 is vertical. Before the locking member 4200 is inserted into the anti-rotation locking opening 2221, the locking member 4200 squeezes the biasing part 4120 into an outwardly expanding shape. When the locking member 4200 is aligned with the anti-rotation locking opening 2221, since the biasing part 4120 needs to return to its original shape, it will generate a force on the locking member 4200 to press against the anti-rotation locking opening 2221, so that the locking member 4200 can smoothly enter the anti-rotation locking opening 2221.

[0055] The base 4110 can be partially or fully sleeved. In this embodiment, the base 4110 is sleeved on the outside of the fixed connection component 2100 in a sleeve-like shape, and is also provided with a clearance portion 4111 so that it can cooperate with the fixed connection component 2100 for positioning. Furthermore, in order to prevent the base 4110 from rotating relative to the fixed connection component 2100, a positioning pin 2110 is provided on the positioning opening 2120 of the fixed connection component 2100, and the positioning pin 2110 passes through the sleeve positioning port 4112 of the base 4110 to position and limit the base 4110.

[0056] The biasing part 4120 can be an elastic component integrally formed with the base 4110. In its original state, it is preferably located on the same plane as the base 4110. When the locking member 4200 is not inserted into the anti-rotation locking opening 2221, one end of the locking member 4200 located inside the fixed connection assembly 2100 abuts against the drive assembly 2200. Therefore, the other end located outside the fixed connection assembly 2100 abuts against the inside of the biasing part 4120, so that the biasing part 4120 is in an open state. As the biasing part 4120 deforms, it continuously provides inward biasing force to the locking member 4200.

[0057] like Figure 4-5 As shown, in this embodiment, the anti-rotation locking opening 2221 is an opening provided on the drive assembly 2200. The requirement for its provision is that it appears on the drive assembly 2200 after the drive assembly 2200 is separated from the control lever 3100. This can be achieved by pulling or removing an obstruction. When the separation action occurs, the anti-rotation locking opening 2221 is simultaneously exposed on the drive assembly 2200.

[0058] The drive assembly 2200 is threaded together. During rotation, when it rotates relative to the fixed connection assembly 2100 to a preset area, the guide hole 2140 and the locking member 4200 inside the guide hole 2140 are positioned in height to correspond to the anti-rotation locking opening 2221. Therefore, when the drive assembly 2200 rotates further and rotates to the same radial position as the anti-rotation locking opening 2221, the locking member 4200 is pressed into the anti-rotation locking opening 2221 under the drive of the locking bias member 4100, so as to achieve the locking of the drive assembly 2200 in the circumferential direction.

[0059] Preferably, in this embodiment, the anti-rotation locking opening 2221 is located at the clutch end 2220 of the transmission rod. That is, the anti-rotation locking opening 2221 is used both to engage with the locking member 4200 for locking and to serve as a connection opening when the clutch end 3120 of the control lever and the clutch end 2220 of the transmission rod are axially separable and anti-rotationally connected. As a preferred embodiment, the anti-rotation locking opening 2221 is part of the outer side of the clutch connection groove. This allows the use of the existing clutch connection groove. After the deformable buckle 3121 of the clutch end 3120 of the control lever disengages, an opening space appears for the locking member 4200 to be pressed in. While achieving the locking effect after disengagement, there is no need to set up other structures to generate the anti-rotation locking opening, which simplifies the design and effectively utilizes the original structure.

[0060] Therefore, before the lever clutch end 3120 and the transmission rod clutch end 2220 are separated, the locking member 4200 cannot be inserted into the anti-rotation locking opening 2221, ensuring that the operation of the rotation drive assembly 2200 can still be realized before the lever 3100 is disengaged; and after the lever clutch end 3120 and the transmission rod clutch end 2220 are disengaged, the space of the anti-rotation locking opening 2221 can be exposed, so that the biasing part 4120 presses the locking member 4200 into the anti-rotation locking opening 2221.

[0061] Specifically, the clutch end 3120 of the control lever is provided with a deformable latch 3121, which can be made of an elastic biocompatible material, such as some biocompatible polymer materials. Another part is provided with a clutch connection groove, in which a locking shaft 2222 is provided to engage with the deformable latch 3121. The locking shaft 2222 is inserted into the connecting shaft hole 2223. Specifically, the deformable latch 3121 has a bayonet 3122 and, after passing through the bayonet 3122, mates with the locking shaft 2222. The control lever clutch end 3123 is equipped with a buckle hole; the control lever clutch end 3120 and the transmission lever clutch end 2220 are connected by a deformable buckle 3121 and a snap-fit ​​shaft 2222. When the tension between the control lever clutch end 3120 and the transmission lever clutch end 2222 is greater than a preset value, the deformable buckle 3121 disengages from the snap-fit ​​shaft 2222. The anti-rotation locking opening 2221 is part of the outer side of the clutch connection groove. When the control lever clutch end 3120 is not located in the anti-rotation locking opening 2221, the locking member 4200 can be pressed in.

[0062] More preferably, based on the above settings, the corresponding preset area is such that when the drive component 2200 moves relative to the fixed connection component 2100 to the preset area, the locking member 4200 is higher than the drive thread portion 2231 and lower than the locking opening 2221.

[0063] Because the closing angle of the clamp varies during release, the axial positions of the fixed connection assembly 2100 and the drive assembly 2200 will also differ. The locking element 4200 will only function when the closing angle is within a specific range by setting the length of the anti-rotation locking opening 2221. For example, in this embodiment, the length of the anti-rotation locking opening 2221, i.e., the groove at the upper end of the drive assembly 2200, is set to ensure that the locking element only functions when the closing angle is within the range of 0° to 60°. Figure 12-13 As shown, the locking member 4200 only functions when the clamping mechanism 1000 and the aforementioned transmission mechanism with anti-rotation function are in use. During the clamping process, when the drive assembly 2200 moves relative to the fixed connection assembly 2100 to the preset area, the opening angle between the corresponding pair of closing members 1100 is in the range of 0° to 60°. Within this range, after the operating lever clutch end 3120 separates from the transmission lever clutch end 2220, the locking member 4200 can insert into the anti-rotation locking opening 2221 to achieve locking when the drive assembly 2200 rotates to the corresponding position.

[0064] The advantage is that the effect is significant when the valve edge-to-edge clamping angle is less than 60°. If the operator accidentally releases the valve when the angle is greater than 60°, the locking element 4200 will not affect the rotation of the drive assembly 2200 because the locking element 4200 is pressed against the shaft of the transmission rod at this time. The operator can still try to re-enter the clutch end 3120 of the control lever into the groove of the drive assembly 2200 through the delivery system, rotate the drive assembly 2200, adjust the closing clamp angle to a suitable position within 60°, and then release the valve.

[0065] Based on the above structural description, the specific operation process of the tissue fixation device used in mitral valve surgery in this embodiment is as follows:

[0066] The fixed device connected to it is pushed forward from the left atrium through the push shaft, passing through the mitral valve to reach the left ventricle. At this time, the closing member 1100 of the clamping mechanism 1000 is in the closed state.

[0067] The relative position of the tissue fixation device and the mitral valve is adjusted by pushing the shaft, so that the two closures 1100 of the tissue fixation device are close to the anterior and posterior leaflets of the mitral valve, respectively. Then, the drive shaft 2230 is rotated, and the base thread 2131 cooperates with the drive thread 2231 to move the drive connecting block to the distal end. The closures 1100 will unfold and flip. At this time, the ends of the two closures 1100 have the maximum distance. After the two closures 1100 form an angle of 180° with each other, they can be further flipped to open to an obtuse angle. This can be used when the positioning is inaccurate or other problems require the fixation device to be removed from the heart. Since the two closures 1100 are at an obtuse angle with each other, the contact surface with the tissue tends to tilt outward during the removal process, so as not to hook the tissue. The removal process is smooth and safe.

[0068] After capturing the petals, the two closing members 1100 control the control line to cause the capturing member 1200 to flip towards the closing member 1100, and the petals are clamped between the closing member 1100 and the capturing member 1200.

[0069] The closing member 1100 will perform a closing and flipping motion with the captured petals and the unfolded grasping member 1200. At this time, there will also be relative displacement or a tendency for relative displacement between the grasping member 1200 and the petals. Due to the pressure generated by the elastic deformation of the grasping member 1200 on the petals, friction will be generated on the contact surface between the grasping member 1200 and the petals during the relative displacement. The direction of the friction force exerted by the grasping member 1200 on the applied petals is towards the direction of the driving connecting block, which gives the grasping plate a "pulling" motion characteristic on the petals.

[0070] When the closing member 1100 is driven to a preset angle, such as the opening angle in this embodiment reaching the range of 0° to 60°, the operating lever clutch end 3120 is separated from the transmission lever clutch end 2220, exposing the space of the anti-rotation locking opening 2221. This allows the biasing part 4120 to press the locking member 4200 into the anti-rotation locking opening 2221, ultimately achieving the locking of the driving assembly 2200 relative to the fixed connection assembly 2100 in the circumferential rotation direction. This further achieves the locking of the opening angle of the closing member 1100.

[0071] Example 2:

[0072] In this embodiment, the difference from Embodiment 1 lies in the anti-rotation locking component 4000, specifically in the different cooperation forms of the locking biasing component 4100 and the locking component 4200.

[0073] In this embodiment, the locking biasing component 4100 and the locking component 4200 are integrally formed. Specifically, see [link to documentation]. Figure 10 To achieve a stable bias, the locking bias member 4100 includes a base 4110 and a biasing part 4120. The end of the biasing part 4120 is fixedly connected to the locking member 4200, preferably integrally formed. The base 4110 is provided on the fixed connection assembly 2100. The biasing part 4120 corresponds to the guide hole 2140. The biasing part 4120 is made of an elastic material, preferably an elastic memory material. Before the locking member 4200 is inserted into the anti-rotation locking opening 2221, the locking member 4200 squeezes the biasing part 4120 into an outwardly expanding shape. When the locking member 4200 is aligned with the anti-rotation locking opening 2221, the biasing part 4120 will return to its original shape, generating a force that squeezes the locking member 4200 towards the anti-rotation locking opening 2221, so that the locking member 4200 can smoothly enter the anti-rotation locking opening 2221. By integrating the locking member 4200 and the locking bias member 4100, the loss of the locking member 4200 can be prevented, and the alignment can be made easier. After the locking member 4200 is inserted into the guide hole 2140 of the fixed connection assembly 2100, relative rotation between the locking bias member 4100 and the fixed connection assembly 2100 can also be prevented.

[0074] In this document, the directional terms such as front, back, top, and bottom are defined based on the location of the components in the accompanying drawings and their relative positions to each other, solely for the purpose of clarity and convenience in expressing the technical solution. It should be understood that the use of these directional terms should not limit the scope of protection claimed in this application.

[0075] Where there is no conflict, the above embodiments and features described herein can be combined with each other.

[0076] The above description is merely a preferred embodiment of the present invention and should not be construed as limiting the scope of the invention. Therefore, any equivalent variations made in accordance with the claims of the present invention are still within the scope of the present invention.

Claims

1. A rotation-preventing transmission mechanism of a tissue fixation device, comprising: a support mechanism (2000) including a fixed connection assembly (2100) and a driving assembly (2200) threadedly cooperating with the fixed connection assembly (2100) to achieve axial relative movement, the driving assembly (2200) being axially moved relative to the fixed connection assembly (2100) to drive opening and closing of a clamping mechanism (1000) of the tissue fixation device; a clutch mechanism (3000) including a lever (3100) capable of providing driving force to the driving assembly (2200), the lever (3100) being axially separable and anti-rotationally connected with the driving assembly (2200); characterized in that the rotation-preventing transmission mechanism further comprises: a rotation-preventing locking assembly (4000) including a locking biasing member (4100) and a locking member (4200), the locking biasing member (4100) providing a biasing force to the locking member (4200) towards the driving assembly (2200); the driving assembly (2200) being provided with a rotation-preventing locking opening (2221), and the rotation-preventing locking assembly (4000) being arranged such that when the driving assembly (2200) is in a separated state from the lever (3100) and moved to a preset region relative to the fixed connection assembly (2100), the locking member (4200) is pressed into the rotation-preventing locking opening (2221) by the locking biasing member (4100) to limit rotation of the driving assembly (2200) relative to the fixed connection assembly (2100).

2. The rotation-preventing transmission mechanism according to claim 1, characterized in that: when the locking member (4200) is pressed into the rotation-preventing locking opening (2221), the locking member (4200) is at least partially fixed relative to the fixed connection assembly (2100) in a circumferential direction.

3. The rotation-preventing transmission mechanism according to claim 2, characterized in that: the locking biasing member (4100) is located outside the fixed connection assembly (2100), the fixed connection assembly (2100) includes a guide hole (2140), and the locking member (4200) is pressed into the rotation-preventing locking opening (2221) after passing through the guide hole (2140).

4. The rotation-preventing transmission mechanism according to claim 3, characterized in that: the locking biasing member (4100) includes a base (4110) and a biasing portion (4120), the base is arranged on the fixed connection assembly (2100), and the biasing portion (4120) corresponds in position to the guide hole (2140).

5. The rotation-preventing transmission mechanism according to claim 1, characterized in that: the driving assembly (2200) includes a transmission rod clutch end (2220), the lever (3100) includes a lever clutch end (3120) axially separable and anti-rotationally connected with the transmission rod clutch end (2220); and the rotation-preventing locking opening (2221) is arranged on the transmission rod clutch end (2220).

6. The anti-rotation transmission mechanism according to claim 5, characterized in that, when the operating lever clutch end (3120) and the transmission lever clutch end (2220) are in the undetached state, the operating lever clutch end (3120) is at least partially located in the anti-rotation locking opening (2221) to hinder the locking member (4200) from being pressed into the anti-rotation locking opening (2221).

7. The anti-rotation transmission mechanism according to claim 6, characterized in that, the fixed connection assembly (2100) comprises a base shell, and a base inner cavity (2130) is arranged in the base shell, and a base threaded portion (2131) is arranged in the base inner cavity (2130); the driving assembly (2200) comprises a driving shaft (2230), and the driving shaft (2230) comprises a driving threaded portion (2231) matched with the base threaded portion (2131).

8. The anti-rotation drive mechanism of claim 7, wherein, when the driving assembly (2200) moves to the preset area relative to the fixed connection assembly (2100), the locking member (4200) is higher than the driving threaded portion (2231) and lower than the locking opening (2221).

9. A tissue fixation device, comprising: The anti-rotation transmission mechanism according to any one of claims 1-8 is used in a clamping mechanism (1000).

10. The tissue fixation device of claim 9, wherein, The clamping mechanism (1000) comprises a pair of closing members (1100); when the driving assembly (2200) moves to the preset area relative to the fixed connection assembly (2100), the opening angle range between a corresponding pair of the closing members (1100) is 0°-60°.

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