An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and a preparation method thereof

Abstract

The present invention belongs to the technical field of cosmetics, and particularly relates to an anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and a preparation method thereof. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention is prepared from 1.5 - 4.4 parts of a skin protectant, 1 - 5 parts of a humectant, 0.2 - 0.5 parts of an antioxidant, 0.5 - 1 part of a propellant, and 89.1 - 96.8 parts of water. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention starts from both exogenous and endogenous aspects of skin aging, selects the components of the anti-wrinkle composition, and formulates the optimal ratio to achieve good anti-wrinkle effects, being mild and non-irritating, having good moisturizing effects, and enhancing skin elasticity.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and particularly relates to an anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and a preparation method thereof. Background Art

[0002] With the increase of age, the human body's metabolism begins to slow down, water and subcutaneous fat decrease, elastic fibers gradually thicken, the skin becomes wrinkled and the luster fades. Skin aging is a prominent manifestation of the aging of the whole body, especially obvious in the facial skin. The number of fibroblasts in the human body gradually decreases, and the collagen and elastic fiber proteins secreted by them are gradually reduced and broken due to oxidation, and the function of forming the epidermis disappears, resulting in uneven collapse, the dermis layer begins to thin, the skin elasticity becomes poor, and wrinkles gradually appear.

[0003] Nowadays, with the improvement of living standards and the upgrading of skin care concepts, the object of anti-aging has developed from people in their 30s and 40s to those in their 20s now. "Anti-initial aging" has been widely spread and well-known in recent years. In response to this phenomenon, there are numerous anti-aging and anti-wrinkle products. However, many anti-wrinkle products either have a single function and poor effects, or are highly irritating and suitable for few users. In view of this problem, it is particularly important to find safe and highly effective anti-wrinkle combined raw materials.

[0004] The patent text with the patent publication number CN111642658A discloses an anti-wrinkle and moisturizing composition, including several components such as collagen tripeptide, proteoglycan, rice ceramide, and sodium carboxymethyl cellulose. This anti-wrinkle and moisturizing composition can not only supplement collagen, restore skin elasticity, and fade fine lines, but also has antioxidant and moisturizing effects. However, this anti-wrinkle and moisturizing composition is an oral preparation and does not directly act on the skin, so the anti-wrinkle effect is slow.

[0005] The patent text with the patent publication number CN110812262A discloses an anti-wrinkle and firming composition, mainly containing more than a dozen active ingredients such as Lactobacillus / Soybean Ferment Filtrate, Hydrolyzed Viola Tricolor Extract, Euglena Gracilis Polysaccharide, and Apple Fruit Cell Culture Extract, and is used in combination with hydrolyzed collagen, glycerin, propylene glycol, etc. This anti-wrinkle and firming composition can not only repair damaged skin, but also nourish the skin, supplement skin moisture, and consolidate the repair effect. However, there are irritating components in its formula, which are highly irritating to sensitive skin.

[0006] In summary, there are common technical problems in the prior art such as single function, poor effects, high irritation, and few suitable users. Summary of the Invention

[0007] In order to overcome the above technical problems, the purpose of the present invention is to provide an anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and a preparation method thereof. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention has both anti-wrinkle and moisturizing effects, can resist skin photoaging, repair skin damage, is mild and non-irritating, and is suitable for people with sensitive skin.

[0008] In order to achieve the above object, the technical solution of the present invention is as follows:

[0009] An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide comprises the following components and their mass percentages: 1.5-4.4 parts of a skin protectant, 1-5 parts of a moisturizer, 0.2-0.5 parts of an antioxidant, 0.5-1 parts of a propellant and 89.1-96.8 parts of water; the skin moisturizer comprises β-nicotinamide mononucleotide.

[0010] Furthermore, the skin protectant in the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide also includes Bidens pilosa L. extract, hydrolyzed Ambrette rhoeas extract and Rosemary leaf extract.

[0011] Furthermore, the mass ratio of the skin protectant components in the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide is: β-nicotinamide mononucleotide: Bidens pilosa extract: hydrolyzed Ambrette coffee extract: Rosemary leaf extract = 3-6: 1-4: 1-3: 4-7.

[0012] Furthermore, the moisturizer in the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide consists of butanediol and 1,2-hexanediol in a mass ratio of 4:1.

[0013] Furthermore, the antioxidant in the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide is p-hydroxyacetophenone.

[0014] Furthermore, the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide also includes a pH regulator, and the pH regulator is citric acid.

[0015] Furthermore, the propellant in the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide is nitrogen.

[0016] The present invention also provides a method for preparing the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, comprising the following steps:

[0017] S1. Add the formulated amount of water to the reactor, heat to 80-85°C, keep warm for half an hour, and cool;

[0018] S2. Heat the formulated amount of moisturizer and antioxidant until dissolved, add the solid particles into the reactor after they are dissolved to be transparent, and stir until uniform;

[0019] S3. Add the formulated amount of skin protectant into the reaction kettle and stir until it is completely dissolved and transparent.

[0020] S4. Continuously add a pH regulator into the reaction kettle and stir until it is completely dissolved and transparent to obtain a liquid agent.

[0021] S5. Place the sachet into an aerosol aluminum can. After sealing the aluminum can, fill it with the formulated amount of propellant, then pour the liquid agent prepared in step S4 into the sachet, code the bottom of the tube, and install the nozzle to obtain the product.

[0022] Further, in step S1 of the preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, cool it to 60 - 65 °C.

[0023] Further, in step S4 of the preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, adjust the pH in the reaction kettle to 5.0 - 5.5 with the pH regulator.

[0024] As people age, the level of nicotinamide adenine dinucleotide (NAD+) in the human body becomes lower and lower, leading to defects in the functions of cell nuclei and mitochondria. As an important energy metabolite with anti-aging effects, NAD+ is the most important substance to maintain the youthful state of the human body and is also one of the essential molecules for maintaining life. And β-nicotinamide mononucleotide (NMN), as the most direct precursor of NAD+, can effectively increase the level of NAD+ in the body, effectively regulate the NAD+ / NADH balance, reduce the mortality rate of cells, increase the level of glutathione (GSH) in cells, repair human keratinocytes, thereby enhancing the antioxidant capacity of cells and achieving the effect of anti-aging. However, NMN belongs to the category of vitamin B derivatives and has poor stability, being prone to discoloration and inactivation, thus greatly reducing its efficacy.

[0025] Bidens pilosa L. extract, as a kind of plant A alcohol, has good effects in combating wrinkles and fine lines, improving skin texture and brightness, etc. It not only does not stimulate the secretion of pro-inflammatory cytokines, but instead reduces the activity of cytokines. And Bidens pilosa L. extract can stimulate growth factors to delay aging, regulate cell proliferation and differentiation, reduce the production of melanin, and stimulate the production of collagen and elastin. Rosmarinus officinalis leaf extract can not only strengthen capillaries, help reduce the signs of skin aging, but also stimulate biological activity and cell growth, reducing fine lines and wrinkles. During the research process of the present invention, it was found that when β-nicotinamide mononucleotide is used in combination with Bidens pilosa L. extract and Rosmarinus officinalis leaf extract, the activity of β-nicotinamide mononucleotide is enhanced and the degree of discoloration is significantly reduced. Therefore, β-nicotinamide mononucleotide, Bidens pilosa L. extract and Rosmarinus officinalis leaf extract play a synergistic effect.

[0026] In addition, the present invention also adds an extract of hydrolyzed Abelmoschus esculentus, known as "plant botulinum toxin", to the skin protectant, which can inhibit muscle contraction, giving consumers a firm feeling on the skin when used, and can increase the activity of free radicals.

[0027] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention adds the humectants butanediol and 1,2-hexanediol to the formula to maintain and increase the water content of the stratum corneum of the skin, and forms a lubricating film on the skin surface to play a sealing role and prevent the evaporation of skin moisture.

[0028] Compared with the prior art, the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention and its preparation method have the following technical advantages:

[0029] (1) The anti-wrinkle composition aerosol provided by the present invention is a two-component package. The liquid material and the propellant are separately present in two independent units and are released in the form of a spray. When using, the product is sprayed evenly back and forth about 15 cm away from the face, and then it can be gently patted with both hands until absorbed, or it can be left to absorb naturally; the spraying amount can be freely controlled by the user, which is convenient to use and can be used freely at 360 degrees; at the same time, in the form of a closed package, it can also effectively slow down the disadvantages of the instability and yellowing of β-nicotinamide mononucleotide.

[0030] (2) The present invention selects the components of the anti-wrinkle composition from both the exogenous and endogenous aspects of skin presbyopia and formulates the optimal ratio to achieve a good anti-wrinkle effect.

[0031] (3) The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention is mild and non-irritating, has a good moisturizing effect, and improves skin elasticity. Detailed Embodiments

[0032] The present invention will be further described below through specific embodiments, but the present invention is not limited to the following embodiments. Those skilled in the art can make various modifications according to the basic idea of the present invention, but as long as they do not deviate from the basic idea of the present invention, they are within the scope of the present invention.

[0033] Example 1. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0034] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide includes the following components and their mass percentages: 4.4 parts of skin protectant, 5 parts of humectant, 0.5 part of antioxidant, 1 part of propellant, and 89.1 parts of water.

[0035] The skin protectant consists of β-nicotinamide mononucleotide: Bidens pilosa extract: Hydrolyzed Abelmoschus esculentus extract: Rosemary leaf extract = 3:1:1:4. The moisturizer consists of butylene glycol and 1,2-hexanediol in a mass ratio of 4:1. The antioxidant is p-hydroxyacetophenone. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide further includes the pH regulator citric acid. The propellant is nitrogen.

[0036] The present invention also provides a preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, which includes the following steps:

[0037] S1. Add the formulated amount of water to the reaction kettle, heat to 80 °C and keep warm for half an hour, then cool to 60 °C;

[0038] S2. Heat the formulated amount of moisturizer and antioxidant until dissolved, and add them to the reaction kettle after the solid particles are dissolved to transparency, and stir until uniform;

[0039] S3. Add the formulated amount of skin protectant to the reaction kettle and stir until completely dissolved and transparent;

[0040] S4. Continue to add the pH regulator to the reaction kettle to adjust the pH value in the reaction kettle to 5.0, and stir until completely dissolved and transparent to obtain a liquid agent;

[0041] S5. Put the sachet into the aerosol aluminum can, seal the aluminum can and fill it with the formulated amount of propellant, then pour the liquid agent prepared in step S4 into the sachet, code the bottom of the tube, and install the nozzle to obtain the product.

[0042] Example 2. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0043] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide includes the following components and their mass percentages: 1.5 parts of skin protectant, 1 part of moisturizer, 0.2 part of antioxidant, 0.5 part of propellant and 96.8 parts of water.

[0044] The skin protectant consists of β-nicotinamide mononucleotide: Bidens pilosa extract: Hydrolyzed Abelmoschus esculentus extract: Rosemary leaf extract = 6:4:3:7. The moisturizer consists of butylene glycol and 1,2-hexanediol in a mass ratio of 4:1. The antioxidant is p-hydroxyacetophenone. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide further includes the pH regulator citric acid. The propellant is nitrogen.

[0045] The present invention also provides a preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, which includes the following steps:

[0046] S1. Add the formulated amount of water to the reaction kettle, heat it to 85 °C, keep it warm for half an hour, and then cool it to 65 °C;

[0047] S2. Heat the formulated amount of humectant and antioxidant until dissolved. After the solid particles are dissolved to transparency, add them to the reaction kettle and stir until homogeneous;

[0048] S3. Add the formulated amount of skin protectant to the reaction kettle and stir until completely dissolved and transparent;

[0049] S4. Continue to add a pH regulator to the reaction kettle to adjust the pH value in the reaction kettle to 5.5, stir until completely dissolved and transparent to obtain a liquid agent;

[0050] S5. Place the sachet into an aerosol aluminum can. After the aluminum can is sealed, fill it with the formulated amount of propellant, and then pour the liquid agent prepared in step S4 into the sachet. Code the bottom of the tube and install the nozzle to obtain the product.

[0051] Example 3. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0052] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide comprises the following components and their mass percentages: 2.8 parts of skin protectant, 3.4 parts of humectant, 0.3 part of antioxidant, 0.7 part of propellant, and 93.4 parts of water.

[0053] The skin protectant consists of β-nicotinamide mononucleotide: Bidens pilosa extract: Hydrolyzed Abelmoschus esculentus extract: Rosemary leaf extract = 5:3:2:6. The humectant consists of butanediol and 1,2-hexanediol in a mass ratio of 4:1. The antioxidant is p-hydroxyacetophenone. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide also includes the pH regulator citric acid. The propellant is nitrogen.

[0054] The present invention also provides a preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, comprising the following steps:

[0055] S1. Add the formulated amount of water to the reaction kettle, heat it to 83 °C, keep it warm for half an hour, and then cool it to 62 °C;

[0056] S2. Heat the formulated amount of humectant and antioxidant until dissolved. After the solid particles are dissolved to transparency, add them to the reaction kettle and stir until homogeneous;

[0057] S3. Add the formulated amount of skin protectant to the reaction kettle and stir until completely dissolved and transparent;

[0058] S4. Continue to add a pH regulator to the reaction kettle to adjust the pH value in the reaction kettle to 5.3, stir until completely dissolved and transparent to obtain a liquid agent;

[0059] S5. Place the sachet into an aerosol aluminum can. After sealing the aluminum can, fill it with the formulated propellant, and then pour the liquid agent prepared in step S4 into the sachet. Code the bottom of the tube, and install the nozzle to obtain the product.

[0060] Comparative Example 1. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0061] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method in this comparative example are similar to those in Example 3.

[0062] The difference between this comparative example and Example 3 is that in this comparative example, the extract of Vigna aconitifolia seeds is used instead of the extract of Bidens pilosa.

[0063] Comparative Example 2. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0064] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method in this comparative example are similar to those in Example 3.

[0065] The difference between this comparative example and Example 3 is that in this comparative example, ergothioneine is used instead of the extract of Rosmarinus officinalis leaves.

[0066] Comparative Example 3. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0067] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method in this comparative example are similar to those in Example 3.

[0068] The difference between this comparative example and Example 3 is that in this comparative example, the skin protectant is composed of β-nicotinamide mononucleotide, the extract of Bidens pilosa, the extract of hydrolyzed Abelmoschus esculentus, and the extract of Rosmarinus officinalis leaves in a mass ratio of 1:1:1:1.

[0069] Comparative Example 4. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0070] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method in this comparative example are similar to those in Example 3.

[0071] The difference between this comparative example and Example 3 is that in this comparative example, sorbitol is used instead of butanediol in the humectant.

[0072] Comparative Example 5. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method

[0073] The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide and its preparation method in this comparative example are similar to those in Example 3.

[0074] The difference between this comparative example and Example 3 is that propylene glycol is used to replace 1,2 - hexanediol in the humectant in this comparative example.

[0075] Test Example 1. Anti - wrinkle effect test

[0076] Test samples: Anti - wrinkle composition aerosols containing β - nicotinamide mononucleotide prepared in Examples 1 - 3 and Comparative Examples 1 - 3;

[0077] Test method: 70 testers aged between 30 and 60 years old were selected. The outer corners of the eyes and the cheeks were used as the target areas (the same area). Subjects with the same degree of wrinkle level on both sides were selected as the objects. One side was randomly selected as the spraying area of the sample, and the other side was the non - spraying area. They were randomly divided into 7 groups. Among them, 6 groups continuously used the test samples for 28 days, and the remaining group was used as the blank example, using deionized water instead of the test sample. The PROMIS system was used to analyze and evaluate the percentage reduction of the depth and area of the wrinkles at the outer corners of the eyes at 7 days, 14 days, and 28 days, and the average value of the percentage reduction of each group was recorded. The skin elasticity tester ELASTIMETER ELM1086 was used to measure the percentage increase in skin elasticity at the cheeks at 7 days, 14 days, and 28 days, and the average value of the percentage increase of each group was recorded.

[0078] Test results: The test results are shown in Table 1 and Table 2.

[0079] Table 1 Test results of anti - wrinkle effect

[0080]

[0081] Table 2 Test results of skin elasticity

[0082] Group Percentage change in skin elasticity at 7 days / % Percentage change in skin elasticity at 14 days / % Percentage change in skin elasticity at 28 days / % Example 1 +6.3 +10.1 +14.5 Example 2 +6.1 +9.7 +13.9 Example 3 +6.7 +10.5 +15.0 Comparative Example 1 +4.4 +6.5 +9.9 Comparative Example 2 +4.6 +6.8 +10.5 Comparative Example 3 +5.1 +8.0 +11.6 Blank Example -0.2 -0.5 -1.1

[0083] Note: - represents reduction, + represents increase.

[0084] As can be seen from Table 1 and Table 2, compared with the blank example in terms of the depth of the tail-eye wrinkles, the increase in the wrinkle area, and the decrease in skin elasticity at 7 days, 14 days, and 28 days, after using the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention for 7 days, the depth of the tail-eye wrinkles decreased by 5.4 - 6.5%, the wrinkle area decreased by 7.9 - 8.8%, and the skin elasticity increased by 6.1 - 6.7%; after using it for 14 days, the depth of the tail-eye wrinkles decreased by 9.1 - 10.4%, the wrinkle area decreased by 13.1 - 14.2%, and the skin elasticity increased by 9.7 - 10.5%; after using it for 28 days, the depth of the tail-eye wrinkles decreased by 11.4 - 12.4%, the wrinkle area decreased by 16.5 - 17.3%, and the skin elasticity increased by 13.9 - 15.0%. Therefore, the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention has a good anti-wrinkle effect and can maintain skin elasticity. Among them, the anti-wrinkle composition aerosol prepared in Example 3 has the best anti-wrinkle performance and is the best embodiment of the present invention.

[0085] Compared with Example 3, in Comparative Example 1, the extract of Vigna aconitifolia seeds was used instead of the extract of Bidens pilosa L., in Comparative Example 2, ergothioneine was used instead of the extract of Rosmarinus officinalis leaves, and in Comparative Example 3, the dosage ratio of each component in the skin protectant was changed. However, after using the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide for 7 days, 14 days, and 28 days, the reduction in the depth of the tail-eye wrinkles, the reduction in the wrinkle area, and the increase in skin elasticity were all less than those in Example 3. This shows that the extract of Bidens pilosa L. and the extract of Rosmarinus officinalis leaves in the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention can effectively reduce the inactivation of the β-nicotinamide mononucleotide component while playing an anti-wrinkle effect, and the three play a synergistic effect. Moreover, the dosage ratio of each component in the skin protectant of the present invention has reached the optimum, and changing this dosage ratio will reduce the anti-wrinkle effect of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide.

[0086] Test Example 2: Moisturizing Effect Test

[0087] Test samples: The anti-wrinkle composition aerosols containing β-nicotinamide mononucleotide prepared in Examples 1 - 3 and Comparative Examples 4 - 5;

[0088] Test method: Sixty subjects were randomly divided into 6 groups. Five of them used the test samples respectively, and the remaining 1 group was used as the blank group, using deionized water instead of the test samples. The inner side of the left and right arms of the subjects, 10 cm from the base of the palm, was selected as the test site. The test samples were sprayed on the test sites of the subjects, and the skin moisture content (%) was measured using a skin moisture tester before use, 30 min and 60 min after use. During the test period, the subjects were not allowed to apply any other cosmetics to the test sites. The measured values of the test sites of each group of subjects were statistically analyzed and the average values were recorded.

[0089] Test results: The test results are shown in Table 3.

[0090] Table 3 Test Results of Moisturizing Effect

[0091] Group Before use / % After 30 min of use / % After 60 min of use / % Example 1 43 81 74 Example 2 45 87 78 Example 3 45 92 85 Comparative Example 4 44 64 51 Comparative Example 5 43 57 49 Blank Group 45 77 64

[0092] As can be seen from Table 2, the skin water content of the subjects using the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention is higher than that of the blank group. Thus, it shows that the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide provided by the present invention has good moisturizing effect. Among them, the skin water content of the subjects in Example 3 is the highest, which is the best example of the present invention.

[0093] Compared with Example 3, in Comparative Example 4 and Comparative Example 5, the common moisturizer components in the art are used to replace the moisturizer components in the present invention respectively, but the moisturizing effect of the prepared anti-wrinkle composition aerosol of β-nicotinamide mononucleotide becomes worse. This shows that the components in the moisturizer provided by the present invention play a synergistic effect, and not all moisturizing components can achieve the technical effects of the present invention.

[0094] The above examples only exemplarily illustrate the preparation method of the present invention, rather than a limitation to the present invention. Any person skilled in this technology in the art shall not modify the above examples without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or changes completed by those with ordinary knowledge in the technical field without departing from the technical idea provided by the present invention are still covered by the claims of the present invention.

Claims

1. An anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide, Characterized in that, It consists of the following components and their mass parts: 1.5 - 4.4 parts of skin protectant, 1 - 5 parts of humectant, 0.2 - 0.5 parts of antioxidant, 0.5 - 1 part of propellant and 89.1 - 96.8 parts of water; the skin protectant consists of β-nicotinamide mononucleotide, Bidens pilosa extract, hydrolyzed Abelmoschus esculentus extract and Rosmarinus officinalis leaf extract; the mass ratio of each component of the skin protectant is: β-nicotinamide mononucleotide: Bidens pilosa extract: hydrolyzed Abelmoschus esculentus extract: Rosmarinus officinalis leaf extract = 3 - 6:1 - 4:1 - 3:4 - 7; the humectant consists of butanediol and 1,2 - hexanediol in a mass ratio of 4:

1.

2. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide according to claim 1, Characterized in that, The antioxidant is p-hydroxyacetophenone.

3. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide according to claim 1, Characterized in that, The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide further includes a pH regulator, and the pH regulator is citric acid.

4. The anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide according to claim 1, Characterized in that, The propellant is nitrogen.

5. The preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide according to claim 3, Characterized in that, It includes the following steps: S1. Add the formulated amount of water to the reaction kettle, heat to 80 - 85 °C and keep warm for half an hour, then cool down; S2. Heat the formulated amount of humectant and antioxidant until dissolved, and add them to the reaction kettle after the solid particles are dissolved to transparency, and stir until uniform; S3. Add the formulated amount of skin protectant to the reaction kettle and stir until completely dissolved and transparent; S4. Continuously add the pH regulator to the reaction kettle and stir until completely dissolved and transparent to obtain a liquid agent; S5. Put the sachet into the aerosol aluminum can, seal the aluminum can and fill it with the formulated amount of propellant, then pour the liquid agent prepared in step S4 into the sachet, code the bottom of the tube, and install the nozzle to obtain the product.

6. The preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide according to claim 5, Characterized in that, Cool down to 60 - 65 °C in step S1.

7. The preparation method of the anti-wrinkle composition aerosol containing β-nicotinamide mononucleotide according to claim 5, Characterized in that, The pH regulator adjusts the pH in the reaction kettle to 5.0 - 5.5 in step S4.

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