Facial cream with moisturizing and soothing effects and preparation method thereof

Abstract

The present invention relates to a facial cream with moisturizing and soothing effects and a preparation method thereof. The facial cream comprises components including a moisturizing and soothing agent, an emulsifier, a thickener, a humectant, a grease, and a solvent; the moisturizing and soothing agent comprises avocado oil and sodium carboxymethyl β-glucan. The facial cream of the present invention specifically combines avocado oil and sodium carboxymethyl β-glucan as moisturizing and soothing ingredients, and is supplemented with an emulsifier, a thickener, a humectant, a grease, a solvent, and other ingredients. The cream not only has excellent moisturizing and soothing effects, but also has a simple formula and good safety. It is particularly suitable for the delicate skin of infants and children, and is not likely to cause irritation risks to infants and children's skin.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and relates to a facial cream with moisturizing and soothing effects and a preparation method thereof, and in particular to a facial cream with moisturizing and soothing effects, a minimalist formula, and suitable for infants and children, and a preparation method thereof. Background Art

[0002] The structure and composition of infant skin are significantly different from those of adults. In terms of basic skin structure, the thickness of the infant epidermis is thinner than that of adults. Therefore, skin care products or external skin products penetrate through the skin of infants and children more directly and easily than those of adults. They also react more strongly to harmful substances and allergenic ingredients. Skin care products with complex formulas and containing allergenic ingredients such as fragrances, alcohol or pigments should be avoided as much as possible for infants and children.

[0003] The barrier function of infant skin is not yet fully developed. It is weaker and more easily damaged than that of adults, and the corresponding transepidermal water loss rate is also faster than that of adults. Therefore, it is particularly important to increase moisturizing and hydration of infant skin to stabilize the skin barrier. Melanin is produced by melanocytes in the skin. Melanin can absorb radiation energy from sunlight, thereby protecting the skin from UV damage. Studies have found that the melanin content in infant skin is significantly lower than that in adults, and children's melanocyte function is not yet fully developed. These characteristics make infant skin more susceptible to UV damage, which can easily lead to a series of skin inflammatory reactions, such as itching and redness.

[0004] Prior art discloses several functional facial creams for infants and children. For example, CN108904330A discloses a camellia oil-based facial cream for infant skincare. The cream is composed of water, camellia seed oil, diglycerin, butylene glycol, glycerin, triglycerides, shea butter oil, polydimethylsiloxane, cetearyl alcohol, glyceryl stearate, citrate, phytosteryl oleate, 1,2-ethylene glycol, meadowfoam seed oil, crabapple seed oil, sodium hyaluronate, gentiana root extract, panthenol, tocopheryl acetate, acrylates / C10-30 alkyl acrylate crosspolymer, allantoin, sodium stearoyl glutamate, caprylyl glycol, xanthan gum, and arginine. This cream effectively soothes everyday skin problems in infants and young children, quickly improving dryness, redness, and roughness, protecting delicate skin with its mild, hormone-free ingredients.

[0005] The formulation design of infant and child cosmetics should adhere to the principles of safety first, essential efficacy, and minimalist formulas. Clearly, the requirements for infant and child skincare products differ significantly from those for adult skincare products, focusing on high safety, essential efficacy, and minimalist formulas. In recent years, consumers have placed increasing emphasis on the safety and efficacy of cosmetics. In particular, the formulation requirements for infant and child cosmetics go beyond safety and efficacy to include minimalist formula design. However, few infant and child cosmetics on the market can meet all of these requirements. Therefore, it is crucial to develop infant and child cosmetics that not only offer excellent moisturizing and soothing properties, but also feature minimalist ingredients and excellent safety. Summary of the Invention

[0006] In view of the deficiencies in the prior art, the object of the present invention is to provide a facial cream with moisturizing and soothing effects and a preparation method thereof, and in particular to provide a facial cream with moisturizing and soothing effects with a minimalist formula suitable for infants and children and a preparation method thereof.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a facial cream with moisturizing and soothing effects, wherein the components of the facial cream include: a moisturizing and soothing agent, an emulsifier, a thickener, a humectant, oil, and a solvent; the moisturizing and soothing agent includes shea butter and sodium carboxymethyl β-glucan.

[0009] The facial cream involved in the present invention specifically combines avocado oil and sodium carboxymethyl β-glucan as moisturizing and soothing ingredients, and is combined with emulsifiers, thickeners, humectants, oils, solvents and other ingredients. It not only has excellent moisturizing and soothing effects, but also has a simple formula and good safety. It is particularly suitable for the delicate skin of infants and children and is not likely to cause irritation risks to infants and children's skin.

[0010] Avocado butter is a natural oil with a fat content of 15%-30%, including up to 80% unsaturated fatty acids. It also contains phytosterols, tocopherols, and squalene, similar to components found in human sebum. Because it lacks soluble proteins that bind to IgE, it rarely causes allergies, whether consumed or used topically. Sodium carboxymethyl β-glucan is a carboxymethylated modification of β-1,3-glucan extracted from yeast walls, resolving the water insolubility of β-1,3-glucan, which makes it difficult to use in cosmetics. Furthermore, its degree of substitution is controlled to no more than 0.75, preserving its biological activity.

[0011] Preferably, the mass percentages of the moisturizing soothing agent, emulsifier, thickener, humectant and oil in the facial cream are 1-35%, 0.3-3%, 0.1-5%, 5-30% and 2-30% respectively.

[0012] When the components of the facial cream of the present invention are combined in the above-mentioned specific mass ratio, the facial cream system is stable, highly safe, and can ensure the moisturizing and soothing effects to the greatest extent.

[0013] The mass percentage of the moisturizing and soothing agent in the facial cream can be, for example, 1%, 5%, 7%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, 33%, 35%, etc.

[0014] The mass percentage of the emulsifier in the facial cream can be, for example, 0.3%, 0.4%, 0.5%, 0.7%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, 2.3%, 2.5%, 2.7%, 2.8%, 3%, etc.

[0015] The mass percentage of the thickener in the cream can be, for example, 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, etc.

[0016] The mass percentage of the moisturizing agent in the facial cream can be, for example, 5%, 7%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, etc.

[0017] The mass percentage of the oil in the facial cream can be, for example, 2%, 5%, 7%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, 30%, etc.

[0018] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0019] Preferably, the moisturizing soothing agent comprises 5-30 parts of avocado oil and 0.05-0.5 parts of sodium carboxymethyl β-glucan in parts by mass.

[0020] When the shea butter and sodium carboxymethyl beta-glucan in the facial cream of the present invention are combined in a specific mass ratio, the synergistic effect in moisturizing and soothing effects is more significant.

[0021] The mass proportions of the avocado tree fat can be 5 parts, 7 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, etc.; the mass proportions of the sodium carboxymethyl β-glucan can be 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc.

[0022] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0023] Preferably, the emulsifier is a combination of hydrogenated lecithin and phytosterols.

[0024] The emulsifier in the face cream of the present invention is preferably a combination of hydrogenated lecithin and phytosterols because the emulsifier formula can achieve excellent emulsification performance at a relatively low addition amount, and at the same time, there are no great restrictions on the choice of oils and fats. The hydrogenated lecithin and phytosterols work together to form a phospholipid bilayer membrane, which is similar in composition and structure to the human cell membrane, has good affinity with the skin, and is safe. At the same time, it also plays a role in protecting and repairing the skin barrier, further promoting the moisturizing and soothing effects.

[0025] Preferably, the emulsifier is a combination of 0.5-2 parts by mass of hydrogenated lecithin and 0.05-0.5 parts by mass of phytosterols.

[0026] When hydrogenated lecithin and phytosterols in the emulsifier are combined in the above-mentioned specific mass ratio, they can more effectively exert excellent emulsifying properties and protect and repair the skin barrier.

[0027] The mass fractions of the above-mentioned hydrogenated lecithin can be selected from 0.5 parts, 0.7 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.7 parts, 2 parts, etc.; the mass fractions of the above-mentioned plant sterols can be selected from 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc.

[0028] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0029] Preferably, the thickener comprises hectorite.

[0030] Hectorite is a natural inorganic mineral with excellent hydrophilic swelling and suspension thixotropy. It can be well dispersed in water, helping to stabilize and thicken the emulsion. It does not contain impurities contained in chemically synthesized thickeners and is relatively safer.

[0031] Preferably, the moisturizer includes any one or a combination of at least two of glycerin, butylene glycol, propylene glycol, methylpropanediol, or sorbitol; more preferably, a combination of glycerin and butylene glycol. This combination of glycerin and butylene glycol can result in smaller emulsified particle size and more stable emulsification, thereby further enhancing the moisturizing and soothing effects of the product.

[0032] Preferably, the oil comprises any one of coconut oil caprylate / caprate, caprylic / capric triglyceride, dicaprylyl carbonate, isopropyl palmitate, cetyl ethylhexanoate, squalane, mineral oil, silicone oil, alkanes, camellia seed oil, olive oil, sunflower oil, rice bran oil, wheat germ oil, cetyl alcohol, cetearyl alcohol, stearyl alcohol or behenyl alcohol, or a combination of at least two thereof.

[0033] Preferably, the solvent is selected from any one or a combination of at least two of deionized water, aloe vera leaf water, birch sap, anthemis nobilis flower water, rose water, witch hazel water or calendula water.

[0034] Preferably, the components of the facial cream further include a preservative.

[0035] Preferably, the preservative comprises any one of p-hydroxyacetophenone, raspberry ketone, 1,2-hexanediol, 1,2-pentanediol, phenoxyethanol, ethylhexylglycerin, caprylyl glycol or caprylhydroxamic acid, or a combination of at least two thereof.

[0036] In a second aspect, the present invention provides a method for preparing the facial cream with moisturizing and soothing effects according to the first aspect, the preparation method comprising the following steps:

[0037] (1) mixing and dissolving avocado oil and fat to obtain a first mixture; mixing and dissolving an emulsifier and a moisturizer to obtain a second mixture; mixing and dissolving sodium carboxymethyl β-glucan, a thickener, and a solvent to obtain a third mixture;

[0038] (2) mixing and dissolving the second mixed material obtained in step (1) with the third mixed material to obtain a fourth mixed material;

[0039] (3) The first mixed material obtained in step (1) and the fourth mixed material obtained in step (2) are mixed and emulsified by high-speed homogenization to obtain the facial cream with moisturizing and soothing effects.

[0040] The preparation process of the facial cream with moisturizing and soothing effects of the present invention is simple and easy to operate, has strong practicality, and is conducive to industrial scale-up production.

[0041] Preferably, the temperature of the mixed dissolution in each step is independently 70-75°C, such as 70°C, 71°C, 72°C, 73°C, 74°C, 75°C, etc.

[0042] Preferably, after emulsification in step (3), the temperature is lowered to 40-45°C, for example, 40°C, 41°C, 42°C, 43°C, 44°C, 45°C, etc.

[0043] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0044] Preferably, when preparing the third mixed material in step (1), a preservative is also added for mixing and dissolving.

[0045] Compared with the prior art, the present invention has the following beneficial effects:

[0046] The facial cream involved in the present invention specifically combines avocado oil and sodium carboxymethyl β-glucan as moisturizing and soothing ingredients, and is combined with emulsifiers, thickeners, humectants, oils, solvents and other ingredients. It not only has excellent moisturizing and soothing effects, but also has a simple formula and good safety. It is particularly suitable for the delicate skin of infants and children and is not likely to cause irritation risks to infants and children's skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 This is a graph showing the results of testing the safety of the facial cream of the present invention using a keratinocyte model;

[0048] Figure 2 This is a diagram showing the results of a zebrafish embryo toxicity test to detect the safety of the facial cream of the present invention. DETAILED DESCRIPTION

[0049] The technical solution of the present invention is further described below by way of specific embodiments. It should be understood by those skilled in the art that the embodiments are merely to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0050] The sources of some of the raw materials involved in the following examples or comparative examples are as follows:

[0051] Shea butter was purchased from AAK Sweden AB under the model number LIPEX Shea.

[0052] Sodium carboxymethyl β-glucan was purchased from Onlida in Texas under the model number CM-Glucan;

[0053] Hydrogenated lecithin was purchased from COSPHATEC GMBH under the model number Cosphaderm SB-75H;

[0054] Phytosterols were purchased from Advanced Organic Materials SA under the model number Advasterol90;

[0055] Hectorite was purchased from Guangzhou Huashi Cosmetics Technology Co., Ltd. under the model HSCLAY EW;

[0056] Cetearyl alcohol was purchased from Teck Guan (China) Ltd. under the model Cetearyl Alcohol;

[0057] Coco-caprylate / caprate is a product available from BASF under the brand name Cetiol C 5C.

[0058] Example 1

[0059] The present embodiment provides a facial cream with moisturizing and soothing effects, the components of which include, by mass percentage: a moisturizing and soothing agent (15% avocado oil, 0.2% sodium carboxymethyl β-glucan), an emulsifier (0.9% hydrogenated lecithin, 0.1% phytosterols), a thickener (1% hectorite), a humectant (10% glycerin, 8% 1,2-butylene glycol), an oil (2% cetearyl alcohol, 10% coconut oil caprylate / caprate), a preservative (0.3% raspberry ketone, 2% 1,2-pentanediol), and the balance is deionized water.

[0060] The preparation method is as follows:

[0061] (1) mixing and dissolving avocado oil and fat at 70° C. to obtain a first mixture; mixing and dissolving an emulsifier and a moisturizer at 70° C. to obtain a second mixture; mixing and dissolving sodium carboxymethyl β-glucan, a thickener, a solvent, and a preservative at 70° C. to obtain a third mixture;

[0062] (2) mixing and dissolving the second mixed material obtained in step (1) and the third mixed material at 75° C. to obtain a fourth mixed material;

[0063] (3) The first mixed material obtained in step (1) and the fourth mixed material obtained in step (2) are mixed at 75° C. and emulsified by high-speed homogenization, and then cooled to 40° C. to obtain the facial cream with moisturizing and soothing effects.

[0064] Example 2

[0065] The present embodiment provides a facial cream with moisturizing and soothing effects, the components of which include, in percentage by mass: a moisturizing and soothing agent (5% avocado oil, 0.05% sodium carboxymethyl β-glucan), an emulsifier (0.9% hydrogenated lecithin, 0.1% phytosterols), a thickener (1% hectorite), a humectant (8% glycerol, 10% propylene glycol), an oil (2% cetyl ethylhexanoate, 10% caprylic / capric triglyceride), a preservative (0.3% raspberry ketone, 2% 1,2-pentanediol), and the balance is deionized water.

[0066] The preparation method is as in Example 1.

[0067] Example 3

[0068] This embodiment provides a facial cream with moisturizing and soothing effects, the components of which include, in percentage by mass: a moisturizing and soothing agent (25% avocado oil, 0.5% sodium carboxymethyl β-glucan), an emulsifier (0.9% hydrogenated lecithin, 0.1% phytosterols), a thickener (1% hectorite), a humectant (10% glycerol, 8% sorbitol), an oil (2% cetyl ethylhexanoate, 10% isopropyl palmitate), a preservative (0.3% raspberry ketone, 2% 1,2-pentanediol), and the balance is deionized water.

[0069] The preparation method is as in Example 1.

[0070] Example 4

[0071] This embodiment provides a facial cream with moisturizing and soothing effects. The composition of the cream differs from that of Example 1 only in that the emulsifier comprises 1% PEG-100 stearate and 1% glyceryl stearate, while the other components remain unchanged. The preparation method thereof is similar to that of Example 1.

[0072] Example 5

[0073] This embodiment provides a facial cream with moisturizing and soothing effects, the composition of which differs from that of Example 1 only in that the moisturizer is only 18% glycerol, and the other components remain unchanged. The preparation method thereof refers to that of Example 1.

[0074] Example 6

[0075] This embodiment provides a facial cream with moisturizing and soothing effects, the composition of which differs from that of Example 1 only in that the moisturizer is only 18% butylene glycol, and the other components remain unchanged. The preparation method thereof refers to that of Example 1.

[0076] Comparative Example 1

[0077] This comparative example provides a facial cream, the composition of which differs from that of Example 1 only in that the shea butter component is missing and its reduced amount is allocated to the coconut oil caprylate / caprate component, while the other components remain unchanged. The preparation method thereof is similar to that of Example 1.

[0078] Comparative Example 2

[0079] This comparative example provides a facial cream, the components of which differ from those of Example 1 only in that the sodium carboxymethyl β-glucan component is missing and its reduced amount is distributed over deionized water, while the other components remain unchanged. The preparation method thereof is similar to that of Example 1.

[0080] Comparative Example 3

[0081] This comparative example provides a facial cream whose components differ from those of Example 1 only in that the shea butter component and the sodium carboxymethyl β-glucan component are missing. A reduced amount of shea butter is allocated to the coconut caprylate / caprate component, and a reduced amount of sodium carboxymethyl β-glucan is allocated to the deionized water component. All other components remain unchanged. The preparation method is similar to that of Example 1.

[0082] Test Example 1

[0083] Product stability evaluation:

[0084] Product stability is the most important performance indicator for emulsified cream formulations and is crucial for ensuring shelf life. Stability tests were conducted on the creams prepared in Examples 1-3. Specific test conditions and results are shown in Table 1. Stability test results were considered passed based on visual observation of samples after returning to room temperature under each test condition. A passing result was considered acceptable if no significant differences in properties were observed between the sample state and pre-test state.

[0085] Table 1

[0086]

[0087] It can be seen from the results in the above table that the facial cream product of the present invention has good stability and can ensure the quality of the product during its shelf life.

[0088] Test Example 2

[0089] Product safety evaluation:

[0090] (1) Safety evaluation of keratinocyte model using MTT method

[0091] The specific method is as follows: Experimental grouping: HaCaT cell (human immortalized keratinocyte) model was used, and 96-well plates were laid for detection, with 6 wells per group, and repeated three times. Control group: normal cell culture medium; Sample group: the cream of Example 1, diluted with cell culture medium to prepare multiple concentration gradients, and HaCaT cell viability was detected after each group was treated for 24 hours. The results are shown in Figure 2. Figure 1 As shown, from Figure 1 It can be seen that the facial cream product of the present invention has a relatively high safety concentration for HaCaT cells. When the concentration is ≤800 mg / L, the cell viability is >95%.

[0092] (2) Zebrafish embryo toxicity test

[0093] The specific method is as follows: 5hpf fertilized zebrafish embryos were placed in a 60mm culture dish, 30 per group, repeated 3 times. The control group was treated with normal embryo culture medium; the sample group was treated with the cream of Example 1, diluted with cell culture medium to prepare multiple concentration gradients, and the hatching rate was tested after 72hpf. The results are shown in Figure 2. Figure 2As shown, from Figure 2 It can be seen that the facial cream product of the present invention is highly safe for zebrafish, and when the concentration is <640 mg / L, the hatching rate is >95%.

[0094] (3) Human skin patch test

[0095] The facial creams prepared in Examples 1-6 were selected for human skin patch tests.

[0096] For specific methods, please refer to Chapter 7, 2 Human Skin Patch Test, 2015 Edition of the "Technical Specifications for Safety of Cosmetics".

[0097] Subjects: A total of 33 subjects, including 5 males and 28 females, aged 21-46 years (mean age 29.9 years), met the voluntary inclusion criteria.

[0098] Test method: Select an area not exceeding 50mm 2 Using a closed patch test method, place approximately 0.020-0.025 mL (g) of the test substance into a suitable patch tester with a depth of approximately 1 mm. Apply the patch tester to the flexed side of the subject's forearm. Remove the test substance after 24 hours. Observe skin reactions 0.5, 24, and 48 hours after removal. Record the results according to the skin reaction grading standards in the "2015 Cosmetic Safety Technical Specifications."

[0099] The skin reaction grading standards of the skin occlusive patch test are shown in Table 2 below, and the human skin patch test results are shown in Table 3 below.

[0100] Table 2

[0101]

[0102] Table 3

[0103]

[0104] It can be seen from the results in the above table that the facial cream product of the present invention has good safety.

[0105] Test Example 3

[0106] Moisturizing effect evaluation:

[0107] According to QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics, the moisturizing effect of the cream products prepared in Examples 1-6 and Comparative Examples 1-3 was tested.

[0108] The subjects were 30 adults aged 18-65 years with healthy skin and no history of skin diseases or allergies, meeting the volunteer inclusion criteria. The test area, the inner forearms of both hands, had no previous skin treatments or cosmetic procedures. The test environment was maintained at a temperature of 21-22°C and a humidity of 50-60%. The test instrument was a MoistureMeter SC (Delfin).

[0109] Before the test, wipe it clean with dry tissue paper and mark the measurement area on the corresponding test area. The test area is 3cm×4cm, and each test area is 2cm apart. After sitting still for 20 minutes, start measuring the blank value. The sample is measured at (2.0±0.1) mg / cm 2 The amount of the product was evenly applied to the measurement area, with pure water used as a blank. The skin moisture content was measured 0.1, 1, 2, 3, and 4 hours after application. The difference between the values ​​and the blank values ​​was used to determine the moisture content increase. The larger the value, the better the moisturizing effect of the test sample. The results are shown in Table 4.

[0110] Table 4

[0111] Test products 0.1h 1h 2h 3h 4h Example 1 45.97 36.57 35.35 32.69 31.91 Example 2 41.16 33.45 30.56 28.42 26.34 Example 3 47.28 39.54 36.88 35.98 33.32 Example 4 42.55 35.17 31.26 30.79 27.68 Example 5 43.21 34.26 32.95 30.88 29.90 Example 6 41.84 33.98 32.24 29.76 28.86 Comparative Example 1 34.76 28.55 24.02 18.84 14.65 Comparative Example 2 41.23 31.13 28.28 24.07 21.98 Comparative Example 3 33.55 26.87 23.46 17.76 13.78 Blank group 31.76 26.94 21.02 15.21 10.34

[0112] As can be seen from the data in Table 4, the facial cream of the present invention has excellent moisturizing effect, wherein the type of emulsifier, the formula of the moisturizing soothing agent, and the type of moisturizer all affect the moisturizing effect.

[0113] Test Example 4

[0114] Soothing effect evaluation:

[0115] Experimental method: The number of zebrafish neutrophil migration was measured, and the soothing effect of the cream products prepared in Examples 1-8 and Comparative Examples 1-3 was tested.

[0116] Experimental Grouping: Neutrophil transgenic zebrafish larvae were placed in 60 mm culture dishes 24 hours after hatching, with 10 fish per group, and repeated three times. Each group was tested at 24 hpf, and the concentration of the sample group was 40 mg / L.

[0117] Control group: normal neutrophil transgenic zebrafish larvae (normal embryo culture medium);

[0118] Model group: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium);

[0119] Sample group 1: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + Example 1);

[0120] Sample group 2: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + Example 2);

[0121] Sample group 3: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + Example 3);

[0122] Sample group 4: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + Example 4);

[0123] Sample group 5: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + Example 5);

[0124] Sample group 6: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + Example 6);

[0125] Sample group 7: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + comparative example 1);

[0126] Sample group 8: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + comparative example 2);

[0127] Sample group 9: tail-broken neutrophil transgenic zebrafish larvae (normal embryo culture medium + comparative example 3);

[0128] The test statistical results are shown in Table 5.

[0129] Table 5

[0130]

[0131]

[0132] As can be seen from the data in Table 5, the facial cream of the present invention has excellent soothing effect, wherein the type of emulsifier, the formula of the moisturizing soothing agent, and the type of moisturizer all affect the soothing effect.

[0133] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate a moisturizing and soothing facial cream and its preparation method, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent replacements for various raw materials in the product of the present invention, addition of auxiliary ingredients, and selection of specific methods, etc., are all within the scope of protection and disclosure of the present invention.

[0134] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the scope of protection of the present invention.

[0135] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A facial cream with moisturizing and soothing effects, characterized in that: The components of the facial cream include: moisturizing soothing agent, emulsifier, thickener, moisturizing agent, oil, and solvent; The mass percentages of the moisturizing soothing agent, emulsifier, thickener, moisturizer, and oil in the cream are 1-35%, 0.3-3%, 0.1-5%, 5-30%, and 2-30%, respectively; The moisturizing soothing agent comprises 5-30 parts of avocado oil and 0.05-0.5 parts of sodium carboxymethyl β-glucan in parts by mass; The emulsifier is a combination of 0.5-2 parts by mass of hydrogenated lecithin and 0.05-0.5 parts by mass of phytosterols; The moisturizing agent includes any one of glycerin, butylene glycol, propylene glycol, methylpropylene glycol or sorbitol, or a combination of at least two of them.

2. The facial cream with moisturizing and soothing effects according to claim 1, characterized in that The thickener includes hectorite.

3. The facial cream with moisturizing and soothing effects according to claim 1, characterized in that The moisturizing agent is a combination of glycerin and butylene glycol.

4. The facial cream with moisturizing and soothing effects according to claim 1, characterized in that The oil includes any one of coconut oil caprylate / caprate, caprylic / capric triglyceride, dicaprylyl carbonate, isopropyl palmitate, cetyl ethylhexanoate, squalane, mineral oil, silicone oil, alkanes, camellia seed oil, olive oil, sunflower oil, rice bran oil, wheat germ oil, cetyl alcohol, cetearyl alcohol, stearyl alcohol or behenyl alcohol, or a combination of at least two thereof.

5. The facial cream with moisturizing and soothing effects according to claim 1, characterized in that The solvent is selected from any one or a combination of at least two of deionized water, aloe vera leaf water, birch sap, anthemis nobilis flower water, rose water, witch hazel water or calendula water.

6. The facial cream with moisturizing and soothing effects according to claim 1, characterized in that The components of the cream also include preservatives.

7. The facial cream with moisturizing and soothing effects according to claim 6, characterized in that The preservative includes any one of p-hydroxyacetophenone, raspberry ketone, 1,2-hexanediol, 1,2-pentanediol, phenoxyethanol, ethylhexylglycerin, caprylyl glycol or caprylhydroxamic acid, or a combination of at least two thereof.

8. The method for preparing a facial cream with moisturizing and soothing effects according to any one of claims 1 to 7, characterized in that: The preparation method comprises the following steps: (1) mixing and dissolving avocado oil and fat to obtain a first mixture; mixing and dissolving an emulsifier and a moisturizer to obtain a second mixture; mixing and dissolving sodium carboxymethyl β-glucan, a thickener, and a solvent to obtain a third mixture; (2) mixing and dissolving the second mixed material obtained in step (1) with the third mixed material to obtain a fourth mixed material; (3) The first mixed material obtained in step (1) and the fourth mixed material obtained in step (2) are mixed and emulsified by high-speed homogenization to obtain the facial cream with moisturizing and soothing effects.

9. The method for preparing the facial cream with moisturizing and soothing effects according to claim 8, characterized in that: The temperature of the mixed dissolution in each step is independently 70-75°C.

10. The method for preparing the facial cream with moisturizing and soothing effects according to claim 8, characterized in that: After emulsification in step (3), the temperature is lowered to 40-45°C.

11. The method for preparing the facial cream with moisturizing and soothing effects according to claim 8, characterized in that: When preparing the third mixed material in step (1), a preservative is also added for mixing and dissolving.

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