Water-soluble composition as well as preparation method and application thereof

Abstract

The invention relates to a water-soluble composition as well as a preparation method and application thereof, and belongs to the technical field of daily chemical products. The water-soluble composition disclosed by the invention is prepared from the following components in parts by weight: 2 to 6 parts of paeonol glycoside extract, 0.02 to 0.1 part of licochalcone A, 0.02 to 0.12 part of solubilizer and 0.94 to 4.87 parts of water. According to the water-soluble composition, solubilization is assisted by the paeonol glycoside compound, the addition amount of a solubilizer is greatly reduced, the irritation of the solubilizer is remarkably reduced, and the composition is safe and free of irritation. The water-soluble composition disclosed by the invention can be widely applied to cosmetics such as emulsion and face cream, is particularly suitable for a water agent formula, and can be used for remarkably improving the transparency of a product. Through the synergistic effect of the components, the composition disclosed by the invention has the effects of high transdermal property, efficient moisture retention, immediate soothing and red fading and tissue repair promotion. Meanwhile, the water-soluble composition disclosed by the invention is simple in preparation method, economical and feasible, and wide in market prospect.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily chemical products, and particularly relates to a water-soluble composition and a preparation method and application thereof. BACKGROUND

[0002] Licorice Chalcone A (LCA) is a chalcone active ingredient isolated from the rhizome of Glycyrrhiza uralensis, which inhibits free radical-induced skin cell oxidative damage by scavenging skin reactive oxygen species (ROS), and down-regulates the release of proinflammatory mediators such as prostaglandin E2 (PGE2), leukotriene B4 (LTB4), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and has the dual effects of antioxidant and anti-inflammatory. However, LCA is extremely difficult to dissolve in water, which leads to its dual application limitations in practical application. First, it cannot be directly used in transparent water formulations, and second, it has the possibility of crystal precipitation when used in gel, emulsion and cream formulations. Current commercially available water-soluble products mostly use hydroxypropyl-beta-cyclodextrin inclusion technology, or are solubilized by complexing a large amount of polyhydric alcohol / ethanol / solubilizer, but have problems such as sticky and strong irritating skin feel. Nano-emulsification or liposome drug delivery technology can improve solubility, but has high cost and complex process. SUMMARY

[0003] The present application aims to overcome the deficiencies of the prior art and provide a water-soluble composition and a preparation method and application thereof.

[0004] Paeonol glycoside extract is an important active ingredient extracted from Paeonia suffruticosa, and most of the chemical structures are condensates of paeonol and sugars, belonging to phenolic glycoside derivatives, mainly including paeonol glycoside, paeonol proglycoside, paeonol neoglycoside and other compounds. The benzene ring and alkyl chain of the paeonol glycoside in the paeonol glycoside compound have strong hydrophobic properties, and the sugar group provides a hydrophilic outer layer, which can form a nanoparticle micelle through self-assembly in a polar solvent. The hydrophilic shell of the micelle enhances the dispersibility of the system, so that the hydrophobic drug stably exists in the solution, and the apparent solubility is significantly improved. The paeonol glycoside compound can be a commercially available product or a self-made product. The self-made preparation method comprises the following steps: soaking Paeonia suffruticosa root powder with 95% ethanol, refluxing and extracting, combining the extract, concentrating under reduced pressure to a extract, suspending with distilled water, adding methanol extraction, extracting the water phase with saturated n-butanol, combining the n-butanol phase and concentrating, mixing the n-butanol concentrate with crude silica gel at a ratio of 1:1, eluting with ethyl acetate, removing the ethyl acetate under reduced pressure, and adding a polyhydric alcohol to obtain the paeonol glycoside extract.

[0005] Glycyrrhiza chalcone A is a kind of natural flavonoids extracted from Glycyrrhiza inflate, with significant biological activity. Its molecular structure is characterized by α, β-unsaturated ketone. Studies have shown that glycyrrhiza chalcone can inhibit inflammatory response by regulating NF-κB and other signaling pathways, and has significant inhibitory effect on propionibacterium acnes, malassezia and candida albicans, effectively inhibits the growth of acne and comedones, and also has antioxidant and melanin inhibition effects.

[0006] The present application develops a high compatibility water-soluble composition by optimizing the combination of peony phenolic glycoside extract and glycyrrhiza chalcone A. The composition solves the core problems of poor solubility of glycyrrhiza chalcone A in transparent water agent formula and strong irritation caused by high content of solubilizer, and provides an efficient solution for low-viscosity water agent skin care products containing glycyrrhiza chalcone A.

[0007] To achieve the above-mentioned purposes, the technical scheme adopted by the present application is as follows:

[0008] In a first aspect, the present application provides a water-soluble composition comprising the following components in parts by weight: peony phenolic glycoside extract 2-6 parts, glycyrrhiza chalcone A 0.02-0.1 parts, solubilizer 0.02-0.12 parts and water 0.94-4.87 parts.

[0009] The present application solves the problem of poor solubility of glycyrrhiza chalcone A in water agent products by selecting specific components for collocation to obtain a water-soluble composition containing glycyrrhiza chalcone A. At the same time, the water-soluble composition of the present application is non-irritating, effectively avoiding the problem of irritation caused by increasing solubilizer to improve the solubility of glycyrrhiza chalcone A.

[0010] As a preferred embodiment of the water-soluble composition of the present application, the water-soluble composition comprises the following components in parts by weight: peony phenolic glycoside extract 3-6 parts, glycyrrhiza chalcone A 0.02-0.1 parts, solubilizer 0.02-0.12 parts and water 0.94-3.93 parts. Under the preferred ratio range, the water-soluble composition of the present application has better effects of promoting wound healing and moisturizing.

[0011] As a preferred embodiment of the water-soluble composition of the present application, the water-soluble composition comprises the following components in parts by weight: peony phenolic glycoside extract 3-6 parts, glycyrrhiza chalcone A 0.04-0.1 parts, solubilizer 0.02-0.12 parts and water 0.94-3.9 parts. Under the preferred ratio range, the water-soluble composition of the present application has better effects of promoting wound healing and moisturizing.

[0012] As a preferred embodiment of the water-soluble composition of the present application, the water-soluble composition comprises the following components in the weight parts: 3-4.5 parts of peony glycoside extract, 0.05-0.1 parts of glycyrrhiza charltonen A, 0.05-0.12 parts of a solubilizing agent, and 2.28-3.9 parts of water. In the preferred ratio range, the water-soluble composition of the present application has better effects of promoting wound healing and moisturizing.

[0013] As a preferred embodiment of the water-soluble composition of the present application, the water-soluble composition comprises the following components in the weight parts: 3 parts of peony glycoside extract, 0.05 parts of glycyrrhiza charltonen A, 0.05 parts of a solubilizing agent, and 3.9 parts of water. In the preferred ratio range, the water-soluble composition of the present application has better effects of promoting wound healing and moisturizing.

[0014] As a preferred embodiment of the water-soluble composition of the present application, the solubilizing agent is at least one of PPG-13 decyltetradecin polyether-24, PPG-26-butanol polyether-26, polyglyceryl-10 laurate, and polyglyceryl-10 oleate; and preferably PPG-13 decyltetradecin polyether-24.

[0015] The inventors have found through experiments that, in the above preferred formula, the prepared water-soluble composition greatly reduces the addition ratio of the solubilizing agent, has excellent cold and heat resistance, transdermal absorption, safety, no irritation, and high efficiency of moisturizing, immediate soothing and redness reduction, and promotion of tissue repair.

[0016] In a second aspect, the present application provides a preparation method of the above water-soluble composition, comprising the following steps:

[0017] S1, mixing glycyrrhiza charltonen A and peony glycoside extract, ultrasonic oscillation, and mixing to obtain a first component;

[0018] S2, mixing the first component and a solubilizing agent, ultrasonic oscillation, and mixing to obtain a second component;

[0019] S3, mixing the second component and water, ultrasonic oscillation at 40-45°C, mixing, cooling to room temperature, and obtaining the water-soluble composition.

[0020] As a preferred embodiment of the preparation method of the water-soluble composition of the present application, the power of the ultrasonic is 80-150 W, and the ultrasonic time is 2 min-8 min.

[0021] As a preferred embodiment of the preparation method of the water-soluble composition of the present application, the power of the ultrasonic is 120 W, and the ultrasonic time is 4 min.

[0022] In a third aspect, the present application provides use of the above water-soluble composition in the preparation of cosmetics.

[0023] In a fourth aspect, the present invention provides a cosmetic comprising the above-mentioned water-soluble composition.

[0024] As a preferred embodiment of the cosmetic of the present invention, the dosage form of the cosmetic is an aqueous solution, a gel, an emulsion or a cream.

[0025] As a preferred embodiment of the cosmetic of the present invention, the cosmetic comprises 1 to 10% by weight of the above water-soluble composition.

[0026] In a fifth aspect, the present invention provides a toner comprising the following components in weight percentage: 1-10% of the above-mentioned water-soluble composition, 0.42-1.0% of a preservative, 2-10% of an emollient, 0.1-0.3% of a thickener, 0.03-0.5% of a chelating agent and the remainder being water.

[0027] The toner made with this formula has a refreshing and non-sticky feel and is easier to be absorbed by the skin. It has long-lasting moisturizing, instant soothing and redness-removing, and repairing effects.

[0028] As a preferred embodiment of the toner of the present invention, the thickener is at least one of xanthan gum, sodium polyacrylate, and sodium polyacryloyldimethyl taurate, preferably xanthan gum.

[0029] As a preferred embodiment of the toner of the present invention, the preservative is at least one of 4-octanoylhydroxamic acid, 1,2-pentanediol, 1,2-hexanediol, and caprylyl glycol, preferably 4-octanoylhydroxamic acid and 1,2-hexanediol.

[0030] As a preferred embodiment of the toner of the present invention, the emollient is at least one of butylene glycol, dipropylene glycol, 1,3-propylene glycol, glycerin, sorbitol, and panthenol, preferably 1,3-propylene glycol.

[0031] As a preferred embodiment of the toner of the present invention, the chelating agent is at least one of sodium gluconate, EDTA-2Na, and tetrasodium glutamate diacetate, preferably EDTA-2Na.

[0032] As a preferred embodiment of the toner of the present invention, the toner comprises the following components in weight percentage: 6.5% of the above-mentioned aqueous solution composition, 6% of 1,3-propylene glycol, 0.1% of xanthan gum, 0.1% of EDTA-2Na, 0.12% of caprylhydroxamic acid, 0.3% of 1,2-hexanediol and the balance of water.

[0033] In a sixth aspect, the present invention further provides a method for preparing the toner, comprising the following steps:

[0034] S1. Add thickener, emollient, chelating agent and water into a water pot, heat to 75-85°C, stir and homogenize to obtain phase A;

[0035] S2, A phase cooling to 45℃ or below, adding the water-soluble composition, preservative, stirring evenly, to obtain the toner.

[0036] Compared with the prior art, the present application has the following beneficial effects:

[0037] The water-soluble composition of the present application greatly reduces the amount of solubilizer by the auxiliary solubilization of peoniflorin compounds, significantly reduces the irritation of the solubilizer, and is safe and non-irritating. The water-soluble composition of the present application can be widely used in emulsion, cream and other cosmetic dosage forms, and is especially suitable for water agent formulations, which can significantly improve product transparency and achieve the dual requirements of high transparency and high stability. The composition of the present application has high skin permeability, high efficiency of moisturizing, immediate soothing and redness reduction, and promotion of tissue repair through the synergistic effect of components. At the same time, the water-soluble composition of the present application has a simple preparation method, does not require complex equipment or harsh reaction conditions, and has economic and feasibility, and has a wide market prospect. BRIEF DESCRIPTION OF DRAWINGS

[0038] Figure 1 is the product diagram of the water-soluble composition of Example 1 of the present application;

[0039] Figure 2 is the product diagram of toner 1 and comparative toner 5 in the application example of the present application, A represents toner 1, and B represents comparative toner 5;

[0040] Figure 3 is the facial comparison diagram before and after the use of toner 1 in Test Example 5 of the present application. DETAILED DESCRIPTION

[0041] In order to better illustrate the purpose, technical scheme and advantages of the present application, the present application will be further described below in combination with specific examples.

[0042] Other materials, reagents, etc. used in the examples can be obtained from commercial channels if not otherwise specified.

[0043] Peoniflorin extract, liquid, purchased from Hangzhou Guose Shengyan Biotechnology Co., Ltd.

[0044] Glycyrrhizal chalcone A, powder, purchased from Guangzhou Zhenlin Biotechnology Co., Ltd.

[0045] Plant polysaccharide, MF-800, purchased from Guangzhou Zhenlin Biotechnology Co., Ltd.

[0046] Examples 1-5 and Comparative Examples 1-6

[0047] A water-soluble composition comprising the following ingredients in parts by weight: 2-6 parts of peony glycoside extract, 0.02-0.1 parts of glycyrrhiza charltonen A, 0.02-0.12 parts of a solubilizing agent, and 0.94-4.87 parts of water.

[0048] The solubilizing agent is at least one of PPG-13 decyltetradecyl alcohol polyether-24, PPG-26-butanol polyether-26, polyglyceryl-10 laurate, and polyglyceryl-10 oleate.

[0049] The components and parts by weight of the water-soluble compositions of Examples 1-5 and the compositions of Comparative Examples 1-6 are shown in Table 1 below,

[0050] Table 1

[0051]

[0052] The preparation method of the water-soluble compositions of Examples 1-5 and the compositions of Comparative Examples 1-6 comprises the following steps:

[0053] S1, adding glycyrrhiza charltonen A to the peony glycoside extract, stirring, and ultrasonically oscillating at 80-150 W for 2-8 min to fully mix and obtain a first component;

[0054] S2, adding a solubilizing agent to the first component, stirring, and ultrasonically oscillating at 80-150 W for 2-8 min to fully mix and obtain a second component;

[0055] S3, adding water to the second component, stirring, and ultrasonically oscillating at 80-150 W for 2-8 min at 40-45°C to fully mix, and stirring to cool to room temperature to obtain the water-soluble composition.

[0056] The water-soluble compositions of Examples 1-5 are light brown clear liquids. The product diagram of the water-soluble composition of Example 1 is shown in Figure 1 .

[0057] Application Example

[0058] A toner, comprising, in percentage by weight, 1-10% of the above water-soluble composition, 0.42-1.0% of a preservative, 2-10% of an emollient, 0.1-0.3% of a thickening agent, 0.03-0.5% of a chelating agent, and the balance of water. The thickening agent is at least one of xanthan gum, sodium polyacrylate, and sodium polyacryloyldimethyl taurate; the preservative is at least one of p-octanoyl hydroxamic acid, 1,2-pentanediol, and 1,2-hexanediol; the emollient is at least one of butylene glycol, dipropylene glycol, 1,3-propanediol, glycerol, sorbitol, and panthenol; and the chelating agent is at least one of sodium gluconate, EDTA-2Na, and tetrasodium glutamate diacetate.

[0059] Toners were prepared using the water-soluble compositions of Examples 1-5 and the compositions of Comparative Examples 1-6.

[0060] The components of the toners 1-7 and comparative toners 1-6 are shown in Table 2 below,

[0061] Table 2

[0062]

[0063] The preparation method of the toners 1-7 and comparative toners 1-6 comprises the following steps:

[0064] S1, add the emollient (1,3 propanediol), thickening agent (xanthan gum), chelating agent (EDTA-2Na), and water into a water pot, heat to 75-85°C, stir, and homogenize to obtain phase A;

[0065] S2, cool phase A to below 45°C, add the composition, preservative (caprylhydroxamic acid, 1,2-hexanediol), stir until uniform, filter the product, and obtain the toner.

[0066] The toner 1-7 is a clear and transparent light yellow liquid, and the comparative toners are turbid due to different components. The product images of the toner 1 and comparative toner 5 are shown in Figure 2 , where A represents the toner 1 and B represents the comparative toner 5.

[0067] Test Example 1

[0068] The toners 1-7 and comparative toners 1-6 were used as samples to test the stability of the compositions.

[0069] The test method was as follows: equal amounts of toner samples were placed in normal temperature, -18°C±2°C, and 50°C±2°C conditions, and after 90 days, the samples were taken, returned to room temperature, and observed for stability. If there was no significant change in the pH, odor, appearance, and color of the toner, the stability was considered to pass.

[0070] The stability test results are shown in Table 3 below,

[0071] Table 3

[0072] Room temperature stability -18℃ stability 50℃ stability Toner 1 pass pass pass Toner 2 pass pass pass Toner 3 pass pass pass Toner 4 pass pass pass Toner 5 pass pass pass Toner 6 pass pass pass Toner 7 pass pass pass Comparison Toner 1 pass precipitation pass Comparison Toner 2 pass precipitation pass Comparison Toner 3 pass pass pass Comparison Toner 4 precipitation precipitation precipitation Comparison Toner 5 precipitation precipitation precipitation Comparison Toner 6 precipitation precipitation precipitation

[0073] The results in Table 3 show that the toners prepared using the water-soluble compositions of the examples have good stability, and no precipitate is formed at normal temperature, low temperature, or high temperature.

[0074] According to Examples 1 and Comparative Examples 1 and 2, only using a solubilizing agent to dissolve glycyrrhizin chalcone A, the stability at low temperature is not good, and precipitation occurs.

[0075] According to the embodiment 1 and the comparative example 4, it is known that the solubilizing agent of the present application is replaced by other solubilizing agent which affects the stability of the water-soluble composition.

[0076] According to the embodiment 1 and the comparative example 5, it is known that the peony glycoside extract is replaced by other polysaccharide material, which also affects the stability of the water-soluble composition.

[0077] Test example 2

[0078] The water-soluble compositions of the embodiments 1-5 and the compositions of the comparative examples 1-6 are taken as samples to test the efficacy of the compositions in promoting wound healing.

[0079] Test method: human immortalized keratinocytes (HaCaT cells) are inoculated in a 24-well plate, and the cell inoculation amount is adjusted to reach the fusion state every other day, and the culture solution is BASIC H-DMEM. After 24 hours of adherent culture, a straight mark is drawn on the bottom of the culture plate to ensure uniformity in force, angle and thickness, and the floating cells are washed away with PBS, and new culture solution (containing 1% fetal bovine serum) is added; the cells in the blank control group are not intervened, and the culture solution containing 0.001% sample is added to the experimental group. Select the parts with consistent scratch thickness and same cell density, record the coordinates, and take photos at 0h and 24h respectively for observation, and compare the healing speed of the scratches in each group. The scratch areas in each group are measured by using ImageJ software. The scratch healing rate of the sample is calculated according to the following formula:

[0080] Healing rate (%) = (1-C1 / C0)*100,

[0081] Wherein C1 represents the scratch area at 24H, and C0 represents the scratch area at 0H.

[0082] The test results of the compositions in promoting wound healing are shown in Table 4,

[0083] Table 4

[0084] Example 1 Example 2 Example 3 Example 4 Example 5 Blank control group Healing rate (%) 98.26 90.34 96.17 93.57 97.30 5.7 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Healing rate (%) 64.51 67.62 63.15 75.29 70.63 67.38

[0085] The results in Table 4 show that the scratch healing rate of the water-soluble composition of the embodiments reaches 90.34%-98.26%, while the scratch healing rate of the control group is only 5.7%, which is significantly lower than that of the embodiments. It is shown that the water-soluble composition of the present application has a significant effect in promoting wound healing and promoting tissue repair.

[0086] Comparative example 1 and comparative example 2 compared with embodiment 1, a large amount of solubilizing agent is used to dissolve glycyrrhizal chalcone A, but the effect of promoting wound healing is significantly lower than that of embodiment 1, which shows that the combination of peony glycoside extract and glycyrrhizal chalcone A in the present application not only reduces the amount of solubilizing agent, but also improves the effect of promoting wound healing.

[0087] Compared with Example 1, the corresponding effect of promoting wound healing of Comparative Example 3 and 6 is obviously lower than that of Example 1, which indicates that the combination of peonin glycoside extract and glycyrrhiza chalcone A in the water-soluble composition of the present application has synergistic effect. Meanwhile, it indicates that peonin glycoside extract and glycyrrhiza chalcone A are indispensable components in the composition of the present application.

[0088] Compared with Example 1, the corresponding effect of promoting wound healing of Comparative Example 4 is obviously lower than that of Example 1, which indicates that the solubilizer in the water-soluble composition of the present application must be specific.

[0089] Compared with Example 1, the corresponding effect of promoting wound healing of Comparative Example 5 is obviously lower than that of Example 1, which indicates that the peonin glycoside extract in the water-soluble composition of the present application cannot be replaced by other polysaccharides.

[0090] Test Example 3

[0091] The moisturizing properties of the compositions of Example 1-5 and Comparative Example 1-6 were tested.

[0092] Test method: 24 three-day-old zebrafish embryos were placed in 5 g / L NaCl solution (positive control group) and 0.1 g / L sample solution (experimental group) for culture, and the solvents of the NaCl solution and the sample solution were fish embryo culture solution; at the same time, a blank control group (fish embryo culture solution) was set up, and after 72 h of culture, the fish embryos were photographed under a microscope to measure the tail area and perform statistical analysis, and the changes in the tail area of the fish embryos of the experimental group / positive control group and the blank control group were compared, and the inhibition rate of the tail area reduction was calculated to evaluate the 72-hour moisturizing efficacy of the product.

[0093] The moisturizing rate is the inhibition rate of the tail area reduction of zebrafish embryos, and the inhibition rate = (S-M) / (B-M)*100, wherein: S is the average value of the tail area of the fish embryos in the test group; B is the average value of the tail area of the fish embryos in the blank control group; and M is the average value of the tail area of the fish embryos in the model control group. The inhibition rate is the moisturizing rate.

[0094] The test results of the moisturizing properties of the compositions are shown in Table 5,

[0095] Table 5

[0096] Example 1 Example 2 Example 3 Example 4 Example 5 Model control group 72-hour moisturizing rate (%) 54 37 48 41 53 0 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 72-hour moisturizing rate (%) 12 16 25 33 28 17

[0097] The results in Table 5 show that the 72-hour moisturizing rate of the water-soluble composition of the examples reaches 37%-54%, while the moisturizing rate of the control group is 0. It indicates that the water-soluble composition of the present application has good moisturizing efficacy.

[0098] Comparative Example 1 and Comparative Example 2 compared with Example 1, glycyrrhetinyl chalcone A is dissolved by using a large amount of solubilizer, but the corresponding moisturizing effect is obviously lower than that of Example 1, which shows that the combination of peony glycoside extract and glycyrrhetinyl chalcone A in the application not only can reduce the amount of solubilizer, but also can improve the moisturizing effect of the composition.

[0099] Comparative Example 3 and Comparative Example 6 compared with Example 1, the corresponding moisturizing effect is obviously lower than that of Example 1, which shows that the combination of peony glycoside extract and glycyrrhetinyl chalcone A in the water-soluble composition of the application has synergistic effect. At the same time, it shows that peony glycoside extract and glycyrrhetinyl chalcone A are essential components in the composition of the application.

[0100] Comparative Example 4 compared with Example 1, the solubilizer is replaced by other solubilizers, and the corresponding moisturizing effect is obviously lower than that of Example 1, which shows that the solubilizer in the water-soluble composition of the application must be specific.

[0101] Comparative Example 5 compared with Example 1, peony glycoside extract is replaced by other polysaccharide substances, and the corresponding moisturizing effect is obviously lower than that of Example 1, which shows that peony glycoside extract in the water-soluble composition of the application cannot be replaced by other polysaccharides.

[0102] Test Example 4

[0103] The irritation of the composition was tested by taking samples 1-7 as samples.

[0104] Human skin patch test: 30 healthy subjects aged 20-50 years old without skin disease and no history of allergy were selected, and the human skin patch test was carried out according to the human skin patch test method stipulated in the "Cosmetic Safety Technology Standard" (2015 edition) with the sample of toner.

[0105] Qualified patch material was selected, 0.02-0.025 g of sample was taken in the patch tester, and the control area was blank control (without any substance). The sample and blank control were both pasted on the flexor of the forearm of the test subject, and the palm was pressed to make it evenly pasted on the skin. After 24 hours, the test sample was removed. After removing the test sample patch tester, the skin condition of the sample area and the control area was checked at 0.5 hours, 24 hours and 48 hours respectively.

[0106] The grading standard of adverse reactions of the test area skin: 0 points for negative reaction; 1 point for suspicious: only weak erythema; 2 points for weak positive reaction: erythema, infiltration, edema, and papules may be present; 3 points for strong positive reaction: erythema, infiltration, edema, and papules may be present; 4 points for very strong positive reaction: obvious erythema, severe infiltration, edema, and confluent blisters, the reaction exceeds the test area.

[0107] The subjects all pass the patch test, and the skin lotions 1-7 remove the test material patch tester for 0.5 hours, 24 hours and 48 hours, and no adverse reactions such as skin rash, papules, blisters, etc. are observed. It shows that the skin lotions of the application are mild and have low possibility of causing skin irritation.

[0108] The irritation test results of the skin lotion 1 are shown in Table 6 below,

[0109] Table 6

[0110]

[0111]

[0112] Test Example 5

[0113] Take the skin lotion 1 and the blank skin lotion as samples, and the auxiliary materials of the blank skin lotion and the skin lotion 1 are the same, and the only difference is that the composition is replaced with water. Test the instant soothing and redness-reducing effect of the composition. The test method refers to the “T / BDCA 0005-2023 Cosmetic Soothing Efficacy Test Human Lactic Acid Prickling Test Test Method”: recruit subjects aged 18 or older, without active skin disease history and sensitive to lactic acid, 10 people in each group. In the nasal labial folds of the subjects on both sides, apply filter paper (diameter 0.8±0.1 cm) soaked with 50 mL of 10% lactic acid solution at the same time. When the subjective sensation (prickling sensation or / and itching sensation) of the subjects on both sides of the nasal labial folds is moderate or above, remove the filter paper, use VISIA to measure the red area a* value, and record the subject's semi-subjective evaluation score. 3 minutes after using the sample, set the control group (blank skin lotion), retest the red area a* value and the subject's semi-subjective evaluation score.

[0114] The subjective evaluation is itching and pricking, and the subjective evaluation is scored according to the 4-point method. The scoring standard is: 0 points for no feeling, 1 point for mild feeling, 2 points for moderate feeling, and 3 points for severe feeling. Intermediate scores can be used to describe the degree of feeling, such as 0.5 or his intermediate score.

[0115] Calculate the difference in itching and pricking sensation scores and the improvement rate of the red area a* value of the subjects in each group before and after using the sample. Itching and pricking sensation score difference ΔS = score after use - initial score, a* value improvement rate = [(initial a value - a value after use) / initial a value] x 100%.

[0116] The test results show that after 3 minutes of using the toner containing the composition of the present application and adjuvants, the itching / pain sensation is significantly reduced, and the a* value improvement rate reaches 24%; while the itching / pain sensation corresponding to the adjuvants alone without the composition of the present application is not only not reduced but also increased, and the a* value is not improved. In summary, the composition of the present application has the effect of itching / pain sensation, a* value improvement, i.e. instant soothing and redness reduction.

[0117] The soothing and redness reduction test effect of toner 1 is shown in Table 7, and the facial comparison before and after using toner 1 is shown in Figure 3

[0118] Table 7

[0119] Itching / tingling sensation change difference ΔS a* value improvement rate (%) Toner 1 -3.0 24 Blank toner 0.15 -12

[0120] Finally, it should be noted that the above examples are only used to illustrate the technical solutions of the present application and not to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present application.​

Claims

1. A water-soluble composition, characterized in that The invention comprises the following components in parts by weight: 2-6 parts of peony glycoside extract, 0.02-0.1 parts of licorice chalcone A, 0.02-0.12 parts of solubilizer and 0.94-4.87 parts of water.

2. The water-soluble composition according to claim 1, wherein The water-soluble composition comprises the following components in parts by weight: 3 to 6 parts of paeonol glycoside extract, 0.02 to 0.1 parts of licorice chalcone A, 0.02 to 0.12 parts of a solubilizer, and 0.94 to 3.93 parts of water; And / or, the solubilizer is at least one of PPG-13 decyltetradecyl alcohol polyether-24, PPG-26-butanol polyether-26, polyglyceryl-10 laurate or polyglyceryl-10 oleate.

3. The method for preparing the water-soluble composition according to claim 1 or 2, characterized in that: It includes the following steps: S1. Mixing licorice chalcone A and paeonol glycoside extract, performing ultrasonic shaking, and mixing to obtain a first component; S2, mixing the first component with the solubilizer, and ultrasonically shaking and mixing to obtain the second component; S3. Mix the second component with water, perform ultrasonic shaking at 40-45° C., mix well, and cool to room temperature to obtain the water-soluble composition.

4. The preparation method according to claim 3, wherein The power of the ultrasound is 80 to 150 W; And / or, the ultrasonication time is 2 minutes to 8 minutes.

5. Use of the water-soluble composition according to claim 1 or 2 in the preparation of cosmetics.

6. A cosmetic, characterized in that: It comprises the water-soluble composition according to claim 1 or 2.

7. The cosmetic according to claim 6, wherein The dosage form of the cosmetic is water solution, gel, emulsion or cream.

8. A toner, characterized in that: The composition comprises the following components in weight percentage: The aqueous solution composition according to claim 1 or 2 comprises 1-10%, a preservative 0.42-1.0%, an emollient 2-10%, a thickener 0.1-0.3%, a chelating agent 0.03-0.5% and the balance water.

9. The toner according to claim 8, characterized in that The thickener is at least one of xanthan gum, sodium polyacrylate or sodium polyacryloyldimethyltaurate; and / or, the preservative is at least one of p-octanoylhydroxamic acid, 1,2-pentanediol, 1,2-hexanediol or caprylyl glycol; and / or, the emollient is at least one of butylene glycol, dipropylene glycol, 1,3-propylene glycol, glycerin, sorbitol or panthenol; And / or, the chelating agent is at least one of sodium gluconate, EDTA-2Na or tetrasodium glutamate diacetate.

10. The method for preparing the toner according to claim 8 or 9, characterized in that: The following steps are involved: S1. Add thickener, emollient, chelating agent and water into a water pot, heat to 75-85°C, stir and homogenize to obtain phase A; S2. Cool phase A to below 45° C., add the water-soluble composition and preservative, and stir evenly to obtain the toner.

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