An insecticidal composition and its application

Abstract

The present invention belongs to the technical field of agricultural insecticidal, and discloses an insecticidal composition and its application. The insecticidal composition contains active ingredient A and active ingredient B. The active ingredient A is an allosteric activator of nicotinic acetylcholine receptor (nAChR). The allosteric activator of nicotinic acetylcholine receptor (nAChR) is any one of spinetoram and spinosad. The active ingredient B is a compound of formula I. The mass ratio of the active ingredient A to the active ingredient B is 1:80 to 15:1. The insecticidal composition and / or its preparation of the present invention has good control effects on various pests.

Description

Technical Field

[0001] The present invention relates to the technical field of pesticides, and specifically relates to an insecticidal composition and its application. Background Art

[0002] The molecular formula of Compound I: C 23 H 10 F 12 IN3O2, chemical name: 6-fluoro-N-[2-fluoro-3-[[2-iodo-4-[1,2,2,2-tetrafluoro-1-trifluoromethyl ethyl]-6-trifluoromethylphenyl]amino]carbonyl]phenyl]-3-pyridinecarboxamide, is an anti-parasitic agent developed by Mitsui Chemicals. Compound I is an aromatic carboxylic acid amide derivative, which has insecticidal activity against Lepidoptera, Diptera, Homoptera, etc. The allosteric regulation of GABAR may inhibit its permeability to Cl, depolarize the cell membrane potential, cause insects to be overly excited, convulse and die. Its chemical structural formula is shown as follows:

[0003]

[0004] Spinetoram is a biological insecticide developed by Dow AgroSciences in the United States. It is produced by fermentation of the actinomycete Saccharopolyspora spinosa. Its mechanism of action is to directly act on the nicotinic acetylcholine receptor and γ-aminobutyric acid receptor in the insect nervous system, making it insensitive to excitatory or inhibitory neurotransmission responses, thereby affecting normal nerve activities until the insect body dies. It has stomach toxicity and contact toxicity, and can be used to control pests such as Lepidoptera, Thysanoptera, Diptera, etc. It has a fast insecticidal speed and a long residual period.

[0005] Spinosad is a secondary metabolite produced by aerobic fermentation of Saccharopolyspora spinosa. It is a new type of microbial source insecticide with contact and ingestion toxicity, and its insecticidal spectrum is very wide, mainly including Lepidoptera, Thysanoptera, Coleoptera, Diptera, Hymenoptera, etc. pests. Due to its combination of the safety of biological pesticides and the quick-acting nature of chemically synthesized pesticides, spinosad has the excellent characteristics of being broad-spectrum and highly efficient against pests, safe for humans, non-target animals and the environment, and biodegradable, and is widely accepted.

[0006] The activities of the above-mentioned individual compounds are good. However, at low application rates or when used against individual pests, they do not always meet the high requirements that insecticides, acaricides or nematicides must meet. Therefore, how to effectively protect and utilize existing pesticide resources has become one of the important research directions in the technology of integrated pest management. The inventors of the present invention conducted a large number of experimental studies and found that the compounding of spinetoram or spinosad with the compound of formula I has a significant synergistic effect on a variety of pests, especially on thysanopteran pests at different ratios, and field efficacy tests were carried out on the compound preparations with obvious synergistic effects, providing a scientific basis for the rational chemical control of pests. Summary of the Invention

[0007] Based on the above situation, the present invention provides an insecticidal composition, the active ingredients of which comprise a nicotinic acetylcholine receptor (nAChR) allosteric activator and a compound of formula I. The insecticidal composition has a significant synergistic effect on the control of plant pests at different ratios, especially showing excellent control effects against thysanopteran pests.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] An insecticidal composition, the active ingredients of the insecticidal composition comprise active ingredient A and active ingredient B. The active ingredient A is a nicotinic acetylcholine receptor (nAChR) allosteric activator, and the nicotinic acetylcholine receptor (nAChR) allosteric activator is any one of spinetoram and spinosad. The active ingredient B is a compound of formula I

[0010] The mass ratio of the active ingredient A to the active ingredient B is 1:80 to 15:1;

[0011] Further, the mass ratio of the active ingredient A to the active ingredient B is 1:80, 1:40, 1:32, 1:20, 1:16, 1:10, 1:8, 1:5, 1:3, 1:1, 3:1, 4:1, 5:1, 8:1, 10:1, 15:1;

[0012] Further, the mass ratio of the active ingredient A to the active ingredient B is 1:40 to 15:1;

[0013] Further, the mass ratio of the active ingredient A to the active ingredient B is 1:40, 1:32, 1:20, 1:16, 1:10, 1:8, 1:5, 1:3, 1:1, 3:1, 4:1, 5:1, 8:1, 10:1, 15:1;

[0014] Furthermore, the mass ratio of spinetoram to the compound of formula I is 1:32 to 15:1;

[0015] Furthermore, the mass ratio of spinetoram to the compound of formula I is 1:32, 1:16, 1:8, 1:3, 1:1, 4:1, 8:1, 10:1, 15:1;

[0016] Furthermore, the mass ratio of spinetoram to the compound of formula I is 1:8 to 8:1;

[0017] Furthermore, the mass ratio of spinetoram to the compound of formula I is 1:8, 1:3, 1:1, 4:1, 8:1;

[0018] Furthermore, the mass ratio of spinosad to the compound of formula I is 1:40 to 10:1;

[0019] Furthermore, the mass ratio of spinosad to the compound of formula I is 1:40, 1:20, 1:10, 1:5, 1:3, 3:1, 5:1, 10:1;

[0020] Furthermore, the mass ratio of spinosad to the compound of formula I is 1:40 to 3:1;

[0021] Furthermore, the mass ratio of spinosad to the compound of formula I is 1:40, 1:20, 1:10, 1:5, 1:3, 3:1;

[0022] Furthermore, based on the total weight of the insecticidal composition being 100 wt%, the sum of the contents of active ingredient A and active ingredient B in the insecticidal composition is 5 - 70 wt%;

[0023] Furthermore, the insecticidal composition, in addition to the active ingredients, further comprises auxiliaries and carriers, and the auxiliaries are one or more of a dispersant, an emulsifier, a disintegrant, a stabilizer, a wetting agent, a synergist, a penetrant, an antifoaming agent, a thickener, a preservative, a solvent or a filler;

[0024] The carrier is one or more of kaolin, diatomaceous earth, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

[0025] Furthermore, the wetting agent is selected from a mixture composed of one or more of sodium lauryl sulfate, sodium dodecylbenzenesulfonate, Nekal BX, wetting penetrant F, saponin powder, silkworm excrement or sapindus powder;

[0026] Further, the dispersant is selected from one or more of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, sodium naphthalene sulfonate formaldehyde condensate, alkylphenol polyoxyethylene ether phosphate, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ether or glycerol fatty acid ester polyoxyethylene ether;

[0027] Further, the emulsifier is selected from one or more of calcium alkylbenzene sulfonate, OP series phosphates (nonylphenol polyoxyethylene ether phosphate), phenylphenol polyoxyethylene ether phosphate, ammonium styrene polyoxyethylene ether sulfate, magnesium salt of alkyl biphenyl ether disulfonic acid, triethanolamine salt, benzyl dimethylphenol polyoxyethyl ether, alkylphenol formaldehyde resin polyoxyethyl ether, styrylphenol formaldehyde resin polyoxyethyl ether, styrylphenol polyoxyethyl polypropylene ether, ethylene oxide - propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), castor oil polyoxyethylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, sorbitan monostearate, polyoxyethylene sorbitan fatty acid ester or fatty alcohol polyoxyethylene ether;

[0028] Further, the thickener is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or aluminum magnesium silicate;

[0029] Further, the preservative is selected from one or more of sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, benzisothiazolinone, sodium p - hydroxybenzoate, methyl p - hydroxybenzoate;

[0030] Further, the disintegrant is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, sodium sulfate, low - substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;

[0031] Further, the antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol or urea;

[0032] Further, the defoamer is selected from one or more of silicone oil, silicone compounds, C 10 ~C 20 saturated fatty acid compounds or C8 - C 10 fatty alcohol compounds;

[0033] Further, the solvent is selected from one or more of N,N-dimethylformamide, cyclohexanone, butyl ether, xylene, dimethyl sulfoxide, methanol, ethylene glycol, ethanol, propanol, butanol, trimethylcyclohexanone, N-octylpyrrolidone, toluene, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, diethylene glycol, ethylene glycol methyl ether, ethyl acetate or acetonitrile;

[0034] Further, the stabilizer is selected from one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate, triphenyl phosphate;

[0035] Further, the penetrant is selected from one or more of penetrant JFC, penetrant T, azone or silicone;

[0036] Further, the carrier is one, two or three of a solvent or a filler, and water is preferably deionized water;

[0037] Further, the filler is selected from one or more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

[0038] The above substances can all be obtained commercially;

[0039] This pesticidal composition can be prepared into any preparation dosage form permitted in agriculture as needed;

[0040] Further, the preparation dosage form is a solid preparation, a liquid preparation or a seed treatment preparation;

[0041] Further, the solid preparation is a directly used solid preparation, a dispersible solid preparation or a soluble solid preparation;

[0042] Furthermore, the directly used solid preparation is a powder, a granule, a ball, a tablet or a strip;

[0043] The dispersible solid preparation is a wettable powder, an oil-dispersible powder, an emulsion powder, a water-dispersible granule, an emulsion granule or a water-dispersible tablet;

[0044] The soluble solid preparation is a soluble powder, a soluble tablet or a soluble granule;

[0045] Further, the liquid preparation is a solution preparation, a dispersion liquid preparation, an emulsion preparation, a suspension preparation or a multiphase preparation;

[0046] Furthermore, the solution preparation is a soluble solution, a soluble sol, an oil or a film-forming oil;

[0047] The dispersion liquid preparation is an emulsifiable concentrate, a latex, a dispersible liquid or an ointment;

[0048] The emulsion preparation described above is a water emulsion, an oil emulsion, a microemulsion or an ointment;

[0049] The suspension preparation described above is a suspending agent, a microcapsule suspension, an oil suspension or a dispersible oil suspension;

[0050] The multiphase preparation described above is a suspension emulsion, a microcapsule suspension-suspending agent, a microcapsule suspension-water emulsion or a microcapsule suspension-suspension emulsion;

[0051] Furthermore, the seed treatment preparation described above includes a seed treatment solid preparation or a seed treatment liquid preparation;

[0052] Even further, the seed treatment solid preparation is a seed treatment dry powder or a seed treatment dispersible powder;

[0053] The seed treatment liquid preparation is a seed treatment liquid agent, a seed treatment emulsion and / or a seed treatment suspending agent;

[0054] Furthermore, the preparation dosage form is selected from liquid preparations and / or solid preparations. The solid preparations are wettable powders and water dispersible granules; the liquid preparations are suspending agents, microemulsions, water emulsions and emulsifiable concentrates.

[0055] The present invention also discloses the application of the insecticidal composition as described above in controlling plant pests;

[0056] Furthermore, the plant pests are pests of the order Thysanoptera;

[0057] Further, the Thysanoptera includes, but is not limited to, Scirtothrips citri, citrus thrips, Scirtothrips dorsalis, yellow tea thrips, Taeniothrips rhopalantennalis, Thrips palmi Karny, Frankliniella fusca, tobacco thrips, Frankliniella occidentalis, western flower thrips, Frankliniella shultzei, Frankliniella williamsi (corn thrips), Heliothrips haemorrhaidalis, Riphiphorothrips cruentatus, Scirtothrips spp. and Thrips spp.;

[0058] Further, the thysanopteran pests are Thrips tabaci, western flower thrips, Thrips palmi, Scirtothrips dorsalis;

[0059] Further, the insecticidal composition is applied to the pests to be controlled or the medium on which they grow at an effective dose.

[0060] Compared with the prior art, the beneficial effects of the technical solution of the present invention are as follows:

[0061] 1) The obtained insecticidal composition or its preparation of the present invention has an obvious synergistic effect on the target organisms;

[0062] 2) The insecticidal composition of the present invention is environmentally friendly, can effectively reduce the dosage of pesticides, and reduce the agricultural production cost. Detailed implementation mode

[0063] To make the technical solution, purpose and advantages of the present invention clearer, the present invention is described in conjunction with the following specific embodiments, but the present invention can be implemented in various forms and should not be limited by the embodiments described herein.

[0064] Preparation example of preparation:

[0065] Preparation example 1: 40% spinetoram·compound of formula I wettable powder (1:4)

[0066] By weight percentage, 8% spinetoram, 32% compound of formula I, 7% sodium lignin sulfonate, 2% alkylphenol polyoxyethylene ether, 3.8% flaking powder BX, 3% sodium lauryl sulfate, and kaolin making up the balance;

[0067] Preparation method: The active ingredients, dispersant, wetting agent and filler are mixed according to the formula ratio, stirred evenly in a mixer, crushed in a jet mill and mixed evenly again to prepare the wettable powder of the composition of the present invention.

[0068] Preparation Example 2: 36% spinosad·Formula I compound wettable powder (1:3)

[0069] By weight percentage, spinosad 9%, compound of formula I 27%, sodium lignin sulfonate 10%, sodium polycarboxylate 2%, BX powder 2%, sodium lauryl sulfate 2%, and kaolin making up the balance;

[0070] Preparation method: See Preparation Example 1.

[0071] Preparation Example 3: 32% Spinetoram·Formula I compound water dispersible granules (1:3)

[0072] By weight percentage, 8% spinetoram, 24% compound of formula I, 3% sodium lignin sulfonate, 6.5% naphthalenesulfonate formaldehyde condensate, 3% sodium lauryl sulfate, 6% sodium sulfate, and the balance is made up of starch;

[0073] Preparation method: According to the formula ratio, the active ingredients are added to the carrier, and surfactants and other functional additives are added thereto, mixed, and after air flow grinding, 10-25% water is added, and then kneading, granulation, drying, and screening are carried out to obtain a water-dispersible granule product; or the crushed powder is sprayed with water in a boiling granulator, granulated, dried, and then sieved to obtain the product.

[0074] Preparation Example 4: 25% Spinosad·Formula I compound water dispersible granules (1:4)

[0075] By weight percentage, spinosad 5%, compound of formula I 20%, sodium lignin sulfonate 5%, sodium polycarboxylate 4%, calcium alkylbenzene sulfonate 7%, sodium lauryl sulfate 3%, ammonium sulfate 10%, and starch makes up the balance;

[0076] Preparation method: See Preparation Example 3.

[0077] Preparation Example 5: 18% Spinetoram·Formula I Compound Suspension (2:7)

[0078] Spinetoram 4%, Compound of Formula I 14%, fatty alcohol polyoxyethylene ether 2%, fatty acid polyoxyethylene ether phosphate 3%, naphthalene sulfonate formaldehyde condensate 2%, alkyl aryl polyoxyethylene polyoxypropylene ether 3%, magnesium aluminum silicate 0.5%, benzisothiazolinone 0.02%, white carbon black 0.3%, xanthan gum 0.1%, ethylene glycol 5%, silicone oil 0.5%, deionized water to make up the balance, by weight percentage;

[0079] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional auxiliaries are placed in the reaction kettle in sequence, added with water and mixed evenly, and then subjected to high-speed shearing, wet sand grinding, and finally homogenized and filtered to obtain the suspension product.

[0080] Preparation Example 6: 16% Spinetoram·Compound of Formula I Suspension (1:3)

[0081] Spinetoram 4%, Compound of Formula I 12%, fatty alcohol polyoxyethylene ether 2.5%, sodium polycarboxylate 2%, alkylphenol polyoxyethylene ether phosphate 2.5%, alkyl aryl polyoxyethylene polyoxypropylene ether 3%, magnesium aluminum silicate 0.5%, benzisothiazolinone 0.02%, xanthan gum 0.2%, ethylene glycol 5%, silicone oil 0.5%, deionized water to make up the balance, by weight percentage;

[0082] Preparation method: Refer to Preparation Example 5.

[0083] Preparation Example 7: 16% Spinetoram·Compound of Formula I Suspension (1:2)

[0084] Spinosad 5%, Compound of Formula I 10%, fatty alcohol polyoxyethylene ether 2%, lignosulfonate 1%, naphthalene sulfonate formaldehyde condensate 4%, alkyl aryl polyoxyethylene polyoxypropylene ether 3%, magnesium aluminum silicate 0.5%, white carbon black 0.5%, xanthan gum 0.2%, ethylene glycol 5%, silicone oil 0.5%, benzisothiazolinone 0.02%, deionized water to make up the balance, by weight percentage;

[0085] Preparation method: Refer to Preparation Example 5.

[0086] Indoor activity determination:

[0087] Example 1: Indoor Activity Determination Test of the Compound of Spinetoram, Spinosad and Compound of Formula I against Thrips

[0088] Test method: Glass tube rolling method;

[0089] Test target: Western flower thrips;

[0090] Test agents: 81.2% spinetoram technical, 92% spinosad technical, 96% Compound of Formula I technical, all of the above agents are provided by the R & D Center of Hailir Pharmaceutical Group.

[0091] Test materials: The test insect source was an indoor population continuously reared and propagated in the R & D center. Fresh kidney beans were used as feed for the larvae.

[0092] Rearing conditions: Constant temperature insect rearing room at 25 ± 1 °C, relative humidity 65% ± 5%, light L:D = 14:10 h.

[0093] Determination method: Single-agent stock solutions were prepared respectively, and 5 groups of ratios were designed according to the mixing purpose and agent activity. Five series of mass concentrations were prepared for each single agent and the mixed agents of each group according to the geometric ratio method. 30 adults of Frankliniella occidentalis were selected for each treatment, with 4 replicates. Then they were placed in a light incubator at 25 ± 1 °C, relative humidity 65% ± 5%, and light L:D = 14:10 h.

[0094] Data statistics and analysis:

[0095] According to the survey data, the corrected mortality of each treatment was calculated. Calculations were made according to formulas (1) and (2), and the calculation results were retained to two decimal places:

[0096]

[0097] In the formula:

[0098] P —— Mortality rate, in percentage (%);

[0099] K —— Number of dead insects, in number;

[0100] N —— Total number of insects in the treatment, in number.

[0101]

[0102] In the formula:

[0103] P1 —— Corrected mortality rate, in percentage (%);

[0104] P t —— Treatment mortality rate, in percentage (%);

[0105] P0 —— Mortality rate of the blank control, in percentage (%).

[0106] If the control mortality rate < 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be made according to formula (2); if the control mortality rate > 20%, the test needs to be redone.

[0107] Analysis was carried out using DPS software to obtain the toxicity regression line, LC 50 value and the correlation coefficient r 2 , and evaluate the activity of the test agents against the biological test materials.

[0108] The co-toxicity coefficient (CTC value) of the mixture is calculated according to Formulas (3), (4), and (5):

[0109]

[0110] Where:

[0111] ATI—the measured toxicity index of the mixture;

[0112] S—the LC 50 of the standard insecticide, in milligrams per liter (mg / L);

[0113] M—the LC 50 of the mixture, in milligrams per liter (mg / L).

[0114] TTI = TI A *P A + TI B *P B ···········(4)

[0115] Where:

[0116] TTI—the theoretical toxicity index of the mixture;

[0117] TI A —the toxicity index of Agent A;

[0118] P A —the percentage content of Agent A in the mixture, in percentage (%);

[0119] TI B —the toxicity index of Agent B;

[0120] P B —the percentage content of Agent B in the mixture, in percentage (%).

[0121]

[0122] Where:

[0123] CTC—the co-toxicity coefficient;

[0124] ATI—the measured toxicity index of the mixture;

[0125] TTI—the theoretical toxicity index of the mixture.

[0126] When the co-toxicity coefficient CTC of the compounding is ≥ 120, it shows a synergistic effect; when CTC ≤ 80, it shows an antagonistic effect; when 80 < CTC < 120, it shows an additive effect.

[0127] The test results are shown in the following table:

[0128] Table 1 Indoor bioassay results of the combination of spinetoram and Compound I against Frankliniella occidentalis

[0129] Test agents B value (SE) <![CDATA[Coefficient of correlation r 2 > <![CDATA[LC 50 (95% confidence interval) mg·L -1 > Co-toxicity coefficient CTC Spinetoram 2.177(0.229) 0.981 5.408(4.484～6.641) / Compound of formula I 2.319(0.233) 0.970 77.088(64.547～93.250) / Spinetoram: Compound of formula I = 1:80 2.051(0.223) 0.998 64.052(52.519～78.466) 103.428 Spinetoram: Compound of formula I = 1:32 2.365(0.235) 0.985 42.846(35.974～51.767) 128.362 Spinetoram: Compound of formula I = 1:16 2.362(0.233) 0.973 33.645(28.206～40.237) 128.744 Spinetoram: Compound of formula I = 1:8 2.320(0.232) 0.981 23.039(19.221～27.558) 135.316 Spinetoram: Compound of formula I = 1:3 2.338(0.234) 0.985 9.592(7.932～11.469) 186.310 Spinetoram: Compound of formula I = 1:1 2.026(0.222) 0.987 5.737(4.678～7.015) 176.172 Spinetoram: Compound of formula I = 4:1 2.291(0.232) 0.996 4.433(3.647～5.303) 149.864 Spinetoram: Compound of formula I = 8:1 2.280(0.232) 0.992 4.488(3.691～5.373) 134.383 Spinetoram: Compound of formula I = 10:1 2.281(0.231) 0.984 4.776(3.941～5.717) 123.688 Spinetoram: Compound of formula I = 15:1 2.230(0.230) 0.984 4.713(3.872～5.661) 121.826

[0130] From the results of the indoor bioassay, it can be seen that spinetoram has a relatively high toxicity to Frankliniella occidentalis, and its LC 50 is 5.408 mg / L. When the mass ratio of spinetoram to Compound I is in the range of 1:32 to 15:1, the co-toxicity coefficient is greater than 120, and the combined effect shows a synergistic effect; when the mass ratio of spinetoram to Compound I is in the range of 1:8 to 8:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is significant; when the mass ratio of spinetoram to Compound I is 1:3, the co-toxicity coefficient is the largest, which is 186.310.

[0131] Table 2 Indoor bioassay results of the combination of spinosad and Compound I against Frankliniella occidentalis

[0132]

[0133] From the results of the indoor bioassay, it can be seen that spinosad has a relatively high toxicity to Frankliniella occidentalis, and its LC 50 is 4.212 mg / L. When the mass ratio of spinosad to Compound I is in the range of 1:40 to 10:1, the co-toxicity coefficient is greater than 120, and the combined effect shows a synergistic effect; when the mass ratio of spinosad to Compound I is in the range of 1:20 to 3:1, the co-toxicity coefficient is greater than 150, and the synergistic effect is significant; when the mass ratio of spinosad to Compound I is 1:3, the co-toxicity coefficient is the largest, which is 182.311.

[0134] Field efficacy trials

[0135] Field efficacy trials of the combination of spinetoram, spinosad and Compound I against thrips

[0136] Test target: Thrips

[0137] Test crop: Cowpea 282, sown on June 10, double plants per hole, hole spacing 80 cm×40 cm.

[0138] Test site: This test was carried out in Shouguang, Weifang, Shandong Province. The test site has complete facilities and a relatively high management level. The soil quality of the test site is good and the fertility is uniform.

[0139] Spraying method: Spraying with a GF16-B knapsack electric sprayer.

[0140] Design of test agents:

[0141] Table 3 Design of test agents

[0142] Test number Treatment <![CDATA[Active ingredient dosage (g a.i / hm 2 )]]> 1 32% Spinetoram·Compound of formula I water dispersible granule (1:3) 15 2 18% Spinetoram·Compound of formula I suspension concentrate (2:7) 15 3 36% Spinosad·Compound of formula I wettable powder (1:3) 15 4 25% Spinosad·Compound of formula I water dispersible granule (1:4) 15 5 8% Spinosad aqueous emulsion 20 6 25% Spinetoram water dispersible granule 30 7 25% Compound of formula I water dispersible granule 80 8 5% Chlorantraniliprole suspension concentrate 20 9 Water control -

[0143] Test treatments: Each treatment was replicated 4 times and arranged in a randomized block design. The plot area was 40 m 2 .

[0144] Application method: From 10 days before the test spraying until the end of the test investigation, no other pest and disease control and vegetable picking work were carried out during this period. Spraying was carried out once on July 12; A GF16-B knapsack electric sprayer was used to spray the front and back sides of the cowpea stems and leaves.

[0145] For preparing the medicine, the secondary dilution method was adopted. First, a small amount of water was used to prepare the medicine into a mother liquor. After fully dissolving, the required amount of water was added to prepare the required liquid medicine concentration for spraying. When applying the medicine, thrips were at the peak occurrence period in the field.

[0146] The days of applying the medicine were all sunny days, and the medicine was applied from 4:30 pm to 6:00 pm. The liquid medicine dosage was 450 L / hm 2 , and the water was managed according to the conventional method after applying the medicine.

[0147] The five-point sampling method was adopted. 20 plants were investigated in each plot for a whole-plant investigation. The population base of insects was investigated before applying the medicine, and the control effects were investigated 1 day and 7 days after applying the medicine. The number of live thrips adults was counted, and the reduction rate of the insect population and the control effect were calculated respectively according to the following formulas.

[0148] The test referred to GB / T 17980.13 - 2000, and the reduction rate of the insect population and the control effect were calculated according to the investigation results. The calculation formulas are as follows:

[0149]

[0150]

[0151] Effects on crops and non-target organisms: During the test period, through irregular observations, it was shown that all the test medicaments had no adverse effects on the growth of cowpeas, and no effects on other non-target organisms were found.

[0152] The results of the field efficacy test are shown in the following table:

[0153] Table 4 Results of the field efficacy test of each test medicament against cowpea thrips

[0154]

[0155] Field efficacy tests showed (see Table 4) that for the control of cowpea thrips, the overall control efficacy of different treatments 1 day after application was between 80.88% and 91.24%, and the control efficacy of the mixture of spinetoram or spinosad and the compound of Formula I against cowpea thrips was over 90%. 7 days after application, when the dosage was reduced, the control efficacies of 32% spinetoram·compound of Formula I water dispersible granules (1:3), 18% spinetoram·compound of Formula I suspension concentrate (2:7), 36% spinosad·compound of Formula I wettable powder (1:3), and 25% spinosad·compound of Formula I water dispersible granules (1:4) against cowpea thrips were 92.88%, 93.56%, 94.92%, and 92.73% respectively, all better than the control single agents.

[0156] In summary, through indoor toxicity determination and field efficacy tests, it can be seen that the insecticidal composition of the present invention has good control efficacy against thrips, is safe for target crops, has significant control efficacy, is superior to single agents in delaying the development of drug resistance and prolonging the persistence, can effectively reduce costs, and reduce pesticide residues.

[0157] Although the present invention has been described in detail with general descriptions and specific embodiments above, based on the present invention, some modifications or improvements can be made, which are obvious to those skilled in the art. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of the present invention claimed.

Claims

1. An insecticidal composition, characterized in that, The active ingredients of the pesticidal composition comprise active ingredient A and active ingredient B. The active ingredient A is an allosteric activator of nicotinic acetylcholine receptor (nAChR). The allosteric activator of nicotinic acetylcholine receptor (nAChR) is any one of spinetoram and spinosad. The active ingredient B is a compound of formula I Formula (I). The mass ratio of spinetoram to the compound of formula I is 1:32 to 15:1; the mass ratio of spinosad to the compound of formula I is 1:40 to 10:

1.

2. The pesticidal composition according to claim 1, wherein The mass ratio of spinetoram to the compound of formula I is 1:8 to 8:1; the mass ratio of spinosad to the compound of formula I is 1:40 to 3:

1.

3. The pesticidal composition according to claim 1, wherein Based on the total weight of the pesticidal composition being 100 wt%, the sum of the contents of active ingredient A and active ingredient B in the pesticidal composition is 5 to 70 wt%.

4. The pesticidal composition according to claim 1, wherein In addition to the active ingredients, the pesticidal composition further comprises auxiliaries and carriers. The auxiliaries are one or more of a dispersant, an emulsifier, a disintegrant, a stabilizer, a wetting agent, a synergist, a penetrant, an antifoaming agent, a thickening agent, a preservative or a solvent; the carriers are one or more of kaolin, diatomaceous earth, bentonite, attapulgite, silica white, starch or light calcium carbonate.

5. The pesticidal composition according to claim 1, characterized in that, The pesticidal composition can be prepared into any agriculturally acceptable dosage form, and the dosage forms are selected from liquid dosage forms and / or solid dosage forms. The solid dosage forms are wettable powders and water dispersible granules; the liquid dosage forms are suspension concentrates, microemulsions, emulsifiable concentrates, and aqueous emulsion concentrates.

6. Use of the pesticidal composition according to any one of claims 1-5 in controlling plant pests, characterized in that, The plant pests are thysanopteran pests, and the thysanopteran pests are Thrips tabaci, Frankliniella occidentalis, Thrips palmi and / or Scirtothrips dorsalis.

7. The pesticidal composition according to claim 1, wherein The pesticidal composition is applied to the pests to be controlled and / or the medium on which they grow at an effective dose.

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