Whitening and freckle-removing cream and preparation method thereof

Abstract

The present invention relates to the technical field of daily chemical technology, and specifically provides a whitening and freckle-removing cream. The freckle-removing cream comprises the following components in parts by weight: water, glycerin, mineral oil, antioxidant microcapsules, polydimethylsiloxane, sodium ascorbyl phosphate, niacinamide, a plant compound extract, essence, and cetearyl alcohol. The present invention adds natural plant extract ingredients, which is safe and effective. A circulation device is used to promote the effective combination of active ingredients, so that the active ingredients can quickly penetrate into the inner layer of the skin, thereby improving the transdermal absorption ability of the active ingredients. A unique encapsulation technology is used to firmly adhere the active ingredients to the skin surface, thereby effectively lightening facial spots, removing dullness from the skin, and restoring luster.

Description

Technical Field

[0001] The present invention relates to the technical field of daily chemical products, and in particular to a whitening and freckle-removing cream and a preparation method thereof. Background Art

[0002] Skin problems are becoming a growing concern for people today, and they are devoting more and more time and energy to skin care. Whitening and anti-freckle creams are very popular skincare products. These creams typically use mineral oils for skin conditioning and contain various chemical raw materials to achieve the whitening and freckle-removing effects. However, most whitening and freckle-removing creams on the market have a long-lasting effect and poor efficacy, failing to achieve their intended whitening and freckle-removing effects. The numerous chemical raw materials can easily cause skin allergies. Summary of the Invention

[0003] Purpose of the Invention: To solve the above-mentioned problem, the whitening and freckle-removing cream of the present invention contains niacinamide, ascorbyl phosphate freckle-removing ingredients and antioxidant microcapsules, which can reduce skin spots and pigmentation while improving dullness and brightening skin tone. The plant compound extract is prepared, and the combination of multiple raw materials can better achieve the effect of whitening and freckle removal.

[0004] The core of the invention is that it is made from natural plant extracts, is safe and effective, has no toxic side effects, no allergic reactions, and no sequelae; uses a circulation device to promote the effective combination of active ingredients, allowing the active ingredients to quickly penetrate into the inner layer of the skin, thereby improving the ability of active ingredients to be absorbed through the skin; and through a unique encapsulation technology, the active ingredients are firmly attached to the skin surface. Secondly, it overcomes the low transdermal absorption rate of existing preparation methods.

[0005] The natural plant ingredients of the present invention are prepared by a composite extraction method and a unique extraction method, and the prepared extract has a significant freckle-removing effect.

[0006] The technical solutions of the present invention are as follows:

[0007] The invention provides a whitening and freckle-removing cream, comprising the following components in parts by weight: 60-70 parts of water, 5-7 parts of glycerin, 4-6 parts of mineral oil, 3-5 parts of polydimethylsiloxane, 3-6 parts of sodium ascorbyl phosphate, 1-3 parts of niacinamide, 4-9 parts of plant compound extracts, 0.1-1 part of butylene glycol, 0.1-0.3 part of essence, 7-9 parts of antioxidant microcapsules, and 2-3 parts of cetearyl alcohol.

[0008] Further research shows that the whitening and freckle-removing cream includes the following components in parts by weight: 60-65 parts of water, 5-6 parts of glycerin, 4-5 parts of mineral oil, 3-4 parts of polydimethylsiloxane, 3-5 parts of sodium ascorbyl phosphate, 1-2 parts of niacinamide, 5-8 parts of plant compound extract, 0.1-0.5 parts of butylene glycol, 0.1-0.2 parts of flavor, 7-8 parts of antioxidant microcapsules, and 2.2-2.8 parts of cetearyl alcohol.

[0009] Further research shows that the whitening and freckle-removing cream includes the following components in parts by weight: 65 parts of water, 6 parts of glycerin, 5 parts of mineral oil, 4 parts of polydimethylsiloxane, 4 parts of sodium ascorbyl phosphate, 2 parts of niacinamide, 6 parts of plant compound extract, 0.5 parts of butylene glycol, 0.2 parts of essence, 7.5 parts of antioxidant microcapsules, and 2.5 parts of cetearyl alcohol.

[0010] According to further research, the preparation method of the plant composite extract comprises the following steps:

[0011] Step 1: Crush and sieve the plant, mix the raw material and the extractant at a mass ratio of 1 to 10:1, heat to 50-120°C, stir and extract completely, and filter to collect the filtrate;

[0012] Step 2: Add water to the filter residue, circulate high-pressure carbon dioxide for 40-80 minutes at a temperature of 55-85°C, increase the pressure to 20-60 MPa, filter, and collect the filtrate;

[0013] Step 3: Combine the secondary filtrates and perform rotary evaporation to obtain a plant composite extract.

[0014] According to further research, the plants are 3-7 parts of Scutellaria root, 1-3 parts of Rhodiola rosea, and 0.05-1 parts of Glycyrrhiza glabra.

[0015] According to further research, the composite extractant is composed of bis(trifluoromethanesulfonyl)imide anionic liquid and ethyl acetate, and the weight ratio of bis(trifluoromethanesulfonyl)imide anionic liquid to ethyl acetate is 6-9:1-3.

[0016] Further research showed that the antioxidant microcapsules are composed of isopropyl myristate, glyceryl stearate, tocopheryl acetate, and butylated hydroxytoluene, and the mass ratio of isopropyl myristate, glyceryl stearate, tocopheryl acetate, and butylated hydroxytoluene is 4-6:1-2:0.1-0.6:0.4-0.6.

[0017] Further research has shown that the preparation method of the antioxidant microcapsules is as follows: isopropyl myristate and glyceryl stearate are added to a homogenizer and heated, tocopherol acetate and butylated hydroxytoluene are added, stirred evenly while hot, and then sheared and emulsified to obtain the antioxidant microcapsules.

[0018] Further research has shown that the preparation method of the freckle cream is as follows: first, antioxidant microcapsules are added into water and stirred and heated, then sodium ascorbyl phosphate, niacinamide and plant compound extracts are added and mixed thoroughly, then the remaining raw materials are added and mixed thoroughly, sodium hydroxide is added to adjust the pH to neutral, and then the whitening and freckle cream is obtained by circulating heating and reflux.

[0019] According to further research, the temperature of the circulating heating reflux is 40-50°C.

[0020] Beneficial effects: The present invention adds natural plant extracts, which are safe and effective; the circulation device is used to promote the effective combination of active ingredients, so that the active ingredients can quickly penetrate into the inner layer of the skin, improving the ability of active ingredients to be absorbed through the skin; through the unique packaging technology, the active ingredients are firmly attached to the skin surface, which can effectively lighten facial spots, fade dull skin, and restore luster. DETAILED DESCRIPTION

[0021] Example 1

[0022] This embodiment provides a whitening and freckle-removing cream, comprising the following components in parts by weight: 65 parts of water, 6 parts of glycerin, 5 parts of mineral oil, 4 parts of polydimethylsiloxane, 4 parts of sodium ascorbyl phosphate, 2 parts of niacinamide, 6 parts of plant compound extract, 0.5 part of butylene glycol, 0.2 part of flavor, 7.5 parts of antioxidant microcapsules, and 2.5 parts of cetearyl alcohol.

[0023] The preparation method of the plant composite extract comprises the following steps:

[0024] Step 1: crush and sieve the plant, mix the raw material with the composite extractant at a mass ratio of 5:1, heat to 100°C, stir and extract completely, and filter and collect the filtrate;

[0025] Step 2: Add water to the filter residue, circulate high-pressure carbon dioxide for 60 minutes, increase the pressure to 40 MPa at 70°C, filter, and collect the filtrate;

[0026] Step 3: Combine the secondary filtrates and perform rotary evaporation to obtain a plant composite extract.

[0027] The plants are 5 parts of scutellaria root, 2 parts of rhodiola rosea and 0.5 parts of glycyrrhiza glabra.

[0028] The composite extractant is composed of bis(trifluoromethanesulfonyl)imide anionic liquid and ethyl acetate, and the weight ratio of the bis(trifluoromethanesulfonyl)imide anionic liquid to the ethyl acetate is 7:2.

[0029] The antioxidant microcapsules are composed of isopropyl myristate, glyceryl stearate, tocopheryl acetate and butylated hydroxytoluene, and the mass ratio of isopropyl myristate, glyceryl stearate, tocopheryl acetate and butylated hydroxytoluene is 5:1:0.4:0.5.

[0030] The preparation method of the antioxidant microcapsules is as follows: adding isopropyl myristate and glyceryl stearate into a homogenizer and heating them, then adding tocopherol acetate and butylated hydroxytoluene, stirring evenly while hot, and then shearing and emulsifying to obtain the antioxidant microcapsules.

[0031] The preparation method of the freckle-removing cream comprises the following steps: firstly adding antioxidant microcapsules into water, stirring and heating, then adding sodium ascorbyl phosphate, niacinamide and a plant composite extract and mixing them thoroughly, then adding the remaining raw materials and continuing to mix them, adding sodium hydroxide to adjust the pH to neutral, and then performing circulation heating and reflux to obtain the whitening and freckle-removing cream.

[0032] The temperature of the circulating heating reflux is 45°C.

[0033] Example 2

[0034] This embodiment provides a whitening and freckle-removing cream, comprising the following components in parts by weight: 60 parts of water, 5 parts of glycerin, 4 parts of mineral oil, 3 parts of polydimethylsiloxane, 3 parts of sodium ascorbyl phosphate, 1 part of niacinamide, 4 parts of plant compound extract, 0.1 part of butylene glycol, 0.1 part of fragrance, 7 parts of antioxidant microcapsules, and 2 parts of cetearyl alcohol.

[0035] The preparation method of the plant composite extract comprises the following steps:

[0036] Step 1: Crush and sieve the plant, mix the raw material and the extractant at a mass ratio of 3:1, heat to 80°C, stir and extract completely, and filter and collect the filtrate;

[0037] Step 2: Add water to the filter residue, circulate high-pressure carbon dioxide for 40 minutes, increase the pressure to 20 MPa at 55°C, filter, and collect the filtrate;

[0038] Step 3: Combine the secondary filtrates and perform rotary evaporation to obtain a plant composite extract.

[0039] The plants are 3 parts of scutellaria root, 1 part of rhodiola rosea and 0.05 part of glycyrrhiza glabra.

[0040] The composite extractant is composed of bis(trifluoromethanesulfonyl)imide anionic liquid and ethyl acetate, and the weight ratio of the bis(trifluoromethanesulfonyl)imide anionic liquid to the ethyl acetate is 6:1.

[0041] The antioxidant microcapsules are composed of isopropyl myristate, glyceryl stearate, tocopheryl acetate and butylated hydroxytoluene, and the mass ratio of isopropyl myristate, glyceryl stearate, tocopheryl acetate and butylated hydroxytoluene is 4:1:0.1:0.4.

[0042] The preparation method of the antioxidant microcapsules is as follows: adding isopropyl myristate and glyceryl stearate into a homogenizer and heating them, then adding tocopherol acetate and butylated hydroxytoluene, stirring evenly while hot, and then shearing and emulsifying to obtain the antioxidant microcapsules.

[0043] The preparation method of the freckle-removing cream comprises the following steps: firstly adding antioxidant microcapsules into water, stirring and heating, then adding sodium ascorbyl phosphate, niacinamide and a plant composite extract and mixing them thoroughly, then adding the remaining raw materials and continuing to mix them, adding sodium hydroxide to adjust the pH to neutral, and then performing circulation heating and reflux to obtain the whitening and freckle-removing cream.

[0044] The temperature of the circulating heating reflux is 40°C.

[0045] Example 3

[0046] This embodiment provides a whitening and freckle-removing cream, comprising the following components in parts by weight: 70 parts of water, 7 parts of glycerin, 6 parts of mineral oil, 5 parts of polydimethylsiloxane, 6 parts of sodium ascorbyl phosphate, 3 parts of niacinamide, 9 parts of plant compound extract, 1 part of butylene glycol, 0.3 parts of flavor, 9 parts of antioxidant microcapsules, and 3 parts of cetearyl alcohol.

[0047] The preparation method of the plant composite extract comprises the following steps:

[0048] Step 1: Crush and sieve the plant, mix the raw material and the extractant at a mass ratio of 10:1, heat to 120°C, stir and extract completely, and filter to collect the filtrate;

[0049] Step 2: Add water to the filter residue, circulate high-pressure carbon dioxide for 80 minutes, increase the pressure to 60 MPa at 85°C, filter, and collect the filtrate;

[0050] Step 3: Combine the secondary filtrates and perform rotary evaporation to obtain a plant composite extract.

[0051] The plants are 7 parts of scutellaria root, 3 parts of rhodiola rosea and 1 part of glycyrrhiza glabra.

[0052] The composite extractant is composed of bis(trifluoromethanesulfonyl)imide anionic liquid and ethyl acetate, and the weight ratio of the bis(trifluoromethanesulfonyl)imide anionic liquid to the ethyl acetate is 9:3.

[0053] The antioxidant microcapsules are composed of isopropyl myristate, glyceryl stearate, tocopheryl acetate and butylated hydroxytoluene, and the mass ratio of isopropyl myristate, glyceryl stearate, tocopheryl acetate and butylated hydroxytoluene is 6:2:0.6:0.6.

[0054] The preparation method of the antioxidant microcapsules is as follows: adding isopropyl myristate and glyceryl stearate into a homogenizer and heating them, then adding tocopherol acetate and butylated hydroxytoluene, stirring evenly while hot, and then shearing and emulsifying to obtain the antioxidant microcapsules.

[0055] The preparation method of the freckle-removing cream comprises the following steps: firstly adding antioxidant microcapsules into water, stirring and heating, then adding sodium ascorbyl phosphate, niacinamide and a plant composite extract and mixing them thoroughly, then adding the remaining raw materials and continuing to mix them, adding sodium hydroxide to adjust the pH to neutral, and then performing circulation heating and reflux to obtain the whitening and freckle-removing cream.

[0056] The temperature of the circulating heating reflux is 50°C.

[0057] Comparative Example 1

[0058] The difference between Comparative Example 1 and Example 1 is that no plant composite extract is added in Comparative Example 1.

[0059] Comparative Example 2

[0060] The difference between Comparative Example 2 and Example 1 is that no antioxidant microcapsules are added in Comparative Example 2.

[0061] Comparative Example 3

[0062] The difference between Comparative Example 3 and Example 1 is that the plant composite extract of Comparative Example 3 is extracted with only Scutellaria baicalensis root as a raw material.

[0063] Comparative Example 4

[0064] The difference between Comparative Example 4 and Example 1 is that the plant composite extract of Comparative Example 4 is extracted with only Rhodiola rosea as a raw material.

[0065] Comparative Example 5

[0066] The difference between Comparative Example 5 and Example 1 is that the preparation method of the plant composite extract in Comparative Example 5 is different, and the preparation method is:

[0067] Step 1: Crush and sieve the plant, mix the raw material with a 60% ethanol solution at a mass ratio of 3:1, heat to 80°C, stir and extract completely, filter and collect the filtrate, and perform vacuum drying and distillation to obtain a plant composite extract.

[0068] The plants are 3 parts of scutellaria root, 1 part of rhodiola rosea and 0.05 part of glycyrrhiza glabra.

[0069] Comparative Example 6

[0070] The difference between Comparative Example 6 and Example 1 is that, in the preparation of the freckle cream in Comparative Example 6, the circulating heating reflux preparation step is lacking.

[0071] Efficacy verification

[0072] Forty mice were divided into 10 groups. The hair on the backs and between the shoulder blades of the mice was removed. The mice were then irradiated with ultraviolet light for one hour daily for five consecutive days. Samples of the freckle-removing cream of the example and comparative example were applied daily. A control group was treated with water. After one month of application, the lipofuscin content of an equivalent area was measured. The mice were sacrificed by cervical dislocation. The skin was removed, cut into pieces, weighed, and placed in a test tube. For every 50 mg of sample, 1 ml of hydrolysis solution was added, hydrolyzed at 80°C for 30 minutes, and then mixed with 10 ml of distilled water. Then, 4 ml of the solution was added to 30 mg of activated carbon, mixed, and centrifuged at 3500 rpm for 10 minutes. The lipofuscin content was measured using a VIS-7220 spectrophotometer. The test results are shown in Table 1.

[0073] Table 1

[0074]

[0075] As can be seen from the results in Table 1, the composition prepared by the present invention has a significant whitening and freckle-removing effect, effectively reduces the paper brown matter content in mice, and reduces the pigment content; as can be seen from Comparative Examples 1-2, the plant composite extract and antioxidant microcapsule added by the present invention have a synergistic freckle-removing effect, and the freckle-removing effect is significantly improved compared with not adding one of them; as can be seen from Comparative Examples 3-5, the plant composite extract added by the present invention is extracted and purified using three plant raw materials, and the freckle-removing effect is stronger than that using a single raw material or other preparation methods; as can be seen from Comparative Example 6, the present invention adopts circulating reflux to heat each component, thereby promoting the activation of more components, and the skin absorbs the effective freckle-removing components more fully, and the whitening and freckle-removing effect of the prepared composition is greatly improved.

[0076] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A whitening and freckle-removing cream, characterized in that: The invention comprises the following components in parts by weight: 60-70 parts of water, 5-7 parts of glycerin, 4-6 parts of mineral oil, 3-5 parts of polydimethylsiloxane, 3-6 parts of sodium ascorbyl phosphate, 1-3 parts of niacinamide, 4-9 parts of plant compound extract, 0.1-1 parts of butylene glycol, 0.1-0.3 parts of flavor, 7-9 parts of antioxidant microcapsules, and 2-3 parts of cetearyl alcohol. The preparation method of the plant composite extract comprises the following steps: Step 1: Crush and sieve the plant, mix the raw material with the composite extractant at a mass ratio of 1 to 10:1, heat to 50-120°C, stir and extract completely, and filter to collect the filtrate; Step 2: Add water to the filter residue, circulate high-pressure carbon dioxide for 40-80 minutes at a temperature of 55-85°C, increase the pressure to 20-60 MPa, filter, and collect the filtrate; Step 3: combining the secondary filtrates and performing rotary evaporation to obtain a plant composite extract; The antioxidant microcapsules are composed of isopropyl myristate, glyceryl stearate, tocopheryl acetate, and butylated hydroxytoluene, and the mass ratio of isopropyl myristate, glyceryl stearate, tocopheryl acetate, and butylated hydroxytoluene is 4-6:1-2:0.1-0.6:0.4-0.6; The preparation method of the freckle cream comprises: first adding antioxidant microcapsules into water, stirring and heating, then adding sodium ascorbyl phosphate, niacinamide and plant compound extract and mixing thoroughly, then adding the remaining raw materials and continuing to mix, adding sodium hydroxide to adjust the pH to neutral, and then performing cyclic heating and reflux to obtain the whitening and freckle cream; The plants are 3-7 parts of Scutellaria root, 1-3 parts of Rhodiola rosea, and 0.05-1 part of Glycyrrhiza glabra; The composite extractant is composed of bis(trifluoromethanesulfonyl)imide anionic liquid and ethyl acetate, and the weight ratio of bis(trifluoromethanesulfonyl)imide anionic liquid to ethyl acetate is 6-9:1-3; The preparation method of the antioxidant microcapsules is as follows: adding isopropyl myristate and glyceryl stearate into a homogenizer and heating them, then adding tocopherol acetate and butylated hydroxytoluene, stirring evenly while hot, and then shearing and emulsifying to obtain the antioxidant microcapsules.

2. A whitening and freckle-removing cream according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 60-65 parts of water, 5-6 parts of glycerin, 4-5 parts of mineral oil, 3-4 parts of polydimethylsiloxane, 3-5 parts of sodium ascorbyl phosphate, 1-2 parts of niacinamide, 5-8 parts of plant compound extract, 0.1-0.5 parts of butylene glycol, 0.1-0.2 parts of essence, 7-8 parts of antioxidant microcapsules, and 2.2-2.8 parts of cetearyl alcohol.

3. The whitening and freckle-removing cream according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 65 parts of water, 6 parts of glycerin, 5 parts of mineral oil, 4 parts of polydimethylsiloxane, 4 parts of sodium ascorbyl phosphate, 2 parts of niacinamide, 6 parts of plant compound extract, 0.5 parts of butylene glycol, 0.2 parts of essence, 7.5 parts of antioxidant microcapsules and 2.5 parts of cetearyl alcohol.

4. The whitening and freckle-removing cream according to claim 1, characterized in that: The temperature of the circulating heating reflux is 40-50°C.

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