An interventional intelligent 360-degree ultrasound radiation intravascular thrombolysis catheter

Abstract

The present invention relates to an interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, comprising a catheter body, an ultrasonic guidewire, an ultrasonic transducer, a monitoring device, a driving device and a host; the ultrasonic guidewire runs through the catheter body and both ends of the ultrasonic guidewire are located outside the catheter body; the ultrasonic transducer is located inside the catheter body and fixedly connected to the ultrasonic guidewire; the monitoring device is fixed to the head of the ultrasonic guidewire or the head of the catheter body; the monitoring device is used to monitor blood pressure or thrombus morphology in real time and send it to the host; the driving device is connected to the tail of the ultrasonic guidewire; the driving device is used to drive the ultrasonic guidewire to rotate around its own central axis; the host is located outside the catheter body, for receiving and processing information sent by the monitoring device, and controlling the ultrasonic guidewire to rotate through the driving device to fully dissolve the thrombus. The present invention drives the ultrasonic guidewire of the ultrasonic transducer to rotate through the driving device, thereby achieving a 360-degree ultrasonic irradiation function, ensuring that the thrombus in the entire blood vessel is completely dissolved.

Description

Technical Field

[0001] The present invention belongs to the technical field of thrombolytic devices and relates to an interventional intelligent 360-degree ultrasonic radiation intravascular thrombolytic catheter. Background Art

[0002] Thromboembolic disease is becoming an increasingly significant global health concern. Studies have shown that the top three causes of cardiovascular death worldwide are all related to thrombosis. Thrombosis is a common clinical vascular disease. When blood clots form within a blood vessel to the point of occlusion, thromboembolism occurs. For example, thrombosis in an artery can lead to peripheral artery disease. In advanced stages, thrombosis that completely occludes a blood vessel can cause acute limb ischemia (ALI), potentially leading to amputation or even death. Thrombosis in a coronary artery can cause myocardial infarction, and thrombosis in a cerebral artery can cause ischemic stroke. Abnormal clotting of blood within the lumen of a deep vein can cause deep vein thrombosis (DVT). If the clots travel through the venous system to the lungs, they can lead to pulmonary embolism (PE). In severe cases, PE can cause sudden death.

[0003] Interventional surgical treatment has become the first choice for treating thrombosis worldwide, mainly including the following types of surgery: catheter-directed thrombolysis (CDT), percutaneous mechanical thrombectomy (PMT), percutaneous transluminal angioplasty (PTA) and other interventional techniques. Percutaneous mechanical thrombectomy mainly uses the principle of rotating turbines, fluid dynamics or mechanical shear force to break up or aspirate thrombi, quickly removing or reducing thrombi, but its clinical use also has its limitations. The catheter-directed thrombolysis method is to directly inject thrombolytic drugs into the site of vascular embolism through a multi-side hole catheter for direct thrombolysis, but clinical data show that the risk of massive bleeding, especially intracranial hemorrhage, is relatively high. Therefore, intravascular ultrasonic thrombolysis systems have also been gradually studied and promoted for clinical use. Its working principle is that high-frequency, low-energy ultrasound helps separate fibrin, and can open the ultrastructure of the thrombus to allow it to combine with thrombolytic drugs, thereby achieving more effective thrombolysis at a lower dose.

[0004] Patent CN103228224 discloses an ultrasonic catheter for treating thrombosis caused by intracranial hemorrhage. The ultrasonic catheter uses an ultrasonic guidewire to emit ultrasonic waves and simultaneously injects thrombolytic drugs to dissolve the thrombus.

[0005] Patent CN105025977 discloses a device for delivering compounds to a target area, which is a device for advancing an ultrasonic catheter to the target area, and utilizes a hole in the side of the distal end of the catheter to achieve the function of drug delivery.

[0006] Patent CN113974765 discloses a thrombolytic module for driving microbubble precursors to penetrate into thrombi, and utilizing a combined ultrasound and microbubble treatment method to achieve accelerated dissolution of thrombi.

[0007] Although the above inventions have improved the thrombolysis effect to varying degrees, none of the ultrasonic catheters have achieved 360-degree ultrasonic irradiation function, resulting in low separation efficiency of thrombus fibrin chains and inability to achieve more effective thrombolysis function at a lower dose.

[0008] Therefore, it is of great significance to study a method to realize the 360-degree ultrasound irradiation function of the ultrasound catheter, thereby achieving more effective thrombus thrombolysis function at a lower dose. Summary of the Invention

[0009] The purpose of the present invention is to solve the problems existing in the prior art and to provide an invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter.

[0010] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0011] An interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, comprising a catheter body, an ultrasonic guidewire, an ultrasonic transducer, a monitoring device, a driving device, and a host;

[0012] The ultrasonic guidewire passes through the catheter body and both ends of the ultrasonic guidewire are located outside the catheter body;

[0013] The ultrasonic transducer is located in the catheter body and is fixedly connected to the ultrasonic guidewire; the number of the ultrasonic transducers is one or more, and when the number is two or more, they are spaced apart along the length direction of the ultrasonic guidewire;

[0014] The monitoring device is fixed to the head of the ultrasonic guidewire or the head of the catheter body; the monitoring device is used to monitor blood pressure or thrombus morphology in real time and send it to the host;

[0015] The driving device is connected to the tail of the ultrasonic guidewire; the driving device is used to drive the ultrasonic guidewire to rotate around its own central axis, and the maximum rotation angle is 360 degrees;

[0016] The host is located outside the catheter body and is used to receive and process information sent by the monitoring device, and control the rotation of the ultrasonic guidewire through the driving device to fully dissolve the thrombus.

[0017] As the preferred technical solution:

[0018] As described above, the interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter has one or more delivery ports on the outer wall of the catheter body, and the diameter of the delivery port is 0.01-0.1 mm.

[0019] The interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter described above also includes a condensate delivery device; the tail of the catheter body is provided with a condensate inlet channel, and the head is provided with a condensate outflow channel; the condensate inlet channel is connected to the condensate delivery device, and the condensate delivery device is connected to the host.

[0020] The interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter described above also includes a temperature sensor; the temperature sensor is fixed to the head of the ultrasonic guidewire or the head of the catheter body; the temperature sensor is used to detect the temperature of the condensate and blood mixture and send it to the host; the host is also used to receive the information sent by the temperature sensor and control the rate at which the condensate flows out of the catheter body through the condensate delivery device to ensure that the temperature of the condensate and blood mixture is not higher than 40°C.

[0021] In the above-mentioned interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, the operating frequency of the ultrasonic transducer is 0.5-20 MHz.

[0022] In the above-mentioned interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, the ultrasonic transducer is a sheet-layer structure. When the number of ultrasonic transducers is two or more, the thickness directions of different ultrasonic transducers are parallel to each other.

[0023] As described above, an interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter has a driving device consisting of a spur gear and a servo motor with a gear. The spur gear is fixedly sleeved on the tail of the ultrasonic guidewire, and the gear in the servo motor with a gear is fixedly sleeved on the motor shaft and meshes with the spur gear. When the servo motor rotates a certain angle, the tail of the ultrasonic guidewire can be rotated a certain angle, and the rotation is transmitted to the transducer through the ultrasonic guidewire. The transducer also rotates a certain angle, so that the ultrasonic transducer can achieve 360-degree ultrasonic coverage. The meshing part of the spur gear and the servo motor with a gear is encapsulated in a shell, so that the gear structure is always inside, which is conducive to protecting this structure.

[0024] In the aforementioned invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, the monitoring device is a pressure sensor, which is used to monitor blood pressure in real time and transmit the information to the host. The host controls the movement of the ultrasonic guidewire according to the following process:

[0025] (1) Determine whether the blood pressure monitored by the pressure sensor continues to change. If so, no adjustment is made; otherwise, proceed to the next step;

[0026] (2) Determine whether the time for which the blood pressure monitored by the pressure sensor remains constant exceeds a min. If so, proceed to the next step; otherwise, return to step (1); the value range of a is 0.1-5;

[0027] (3) The ultrasonic guide wire is controlled by a driving device to rotate b degrees around its own central axis in a clockwise direction (or counterclockwise direction, ensuring that the direction of each cycle is the same, that is, the ultrasonic guide wire is always rotated clockwise or always rotated counterclockwise during the entire cycle), and it is determined whether the total angle of rotation of the ultrasonic guide wire around its own central axis (assuming that it undergoes two cycles in total, the ultrasonic guide wire rotates 90 degrees in the first cycle and 60 degrees in the second cycle, then the total angle is 150 degrees) is less than 360 degrees. If so, return to step (1); otherwise, proceed to the next step; the value range of b is 30-90;

[0028] (4) Determine whether the blood pressure monitored by the pressure sensor continues to change. If so, no adjustment is made; otherwise, proceed to the next step;

[0029] (5) Determine whether the time for which the blood pressure monitored by the pressure sensor remains constant exceeds a min. If so, proceed to the next step; otherwise, return to step (4);

[0030] (6) After the doctor manually controls the ultrasonic guidewire to advance c mm axially, return to step (1); the value range of c is 1-20.

[0031] In the above-mentioned invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, the monitoring device is an optical imaging device or an acoustic imaging device. The optical imaging device and the acoustic imaging device are used to monitor the thrombus morphology in real time and transmit it to the host. The host controls the movement of the ultrasonic guidewire according to the following process:

[0032] (1) Determine whether the thrombus distribution in the circumferential direction of the blood vessel is uniform. If not, proceed to the next step; otherwise, proceed to step (3);

[0033] (2) determining whether the front of the ultrasonic transducer is aligned with the portion with the most thrombus; if so, returning to step (1); otherwise, controlling the ultrasonic guidewire to rotate around its own central axis by a certain angle through a driving device so that the front of the ultrasonic transducer is aligned with the portion with the most thrombus, and then returning to step (1);

[0034] (3) After the doctor manually controls the ultrasonic guidewire to advance c mm axially, the process returns to step (1); the value range of c is 1-20.

[0035] The monitoring device is a pressure sensor, an optical imaging device or an acoustic imaging device. The pressure sensor is used to monitor blood pressure in real time and send it to the host. The optical imaging device and the acoustic imaging device are used to monitor the thrombus morphology in real time and send it to the host. The host controls the ultrasonic guide wire to rotate at a certain speed, angle and frequency.

[0036] During operation, as the thrombus dissolves, the pressure sensor can collect the pressure changes in the blood and transmit this change to the host. The host controls the servo motor to rotate a certain angle according to certain program settings to achieve the purpose of 360-degree ultrasound coverage;

[0037] During actual use, the thrombolysis process will last for several hours. According to the pressure value transmitted back by the pressure sensor of the thrombolysis catheter, the angle of the transducer on the ultrasonic guidewire is continuously changed to make the thrombolysis process more uniform and controllable. During the operation, the general position and number of thrombi can be determined by angiography, but angiography only shows information of a cross section, and the exact thrombus situation is still difficult to judge. After the thrombolysis catheter enters the blood vessel and approaches the thrombus area, a pressure value is tested using the pressure sensor at the front end of the ultrasonic guidewire. After the entire catheter passes through the thrombus, a pressure value is tested. Due to the presence of thrombus, the pressure in the blood vessel is affected. Simply put, the more thrombus there is, the greater the difference between the two pressures before and after. Therefore, the degree of thrombolysis can be used to infer the extent of thrombolysis. The degree of pressure change can also be used to feed back to the system host to control the speed, angle and frequency of the ultrasonic guidewire rotation.

[0038] According to the Poiseuille flow formula of fluid in a circular pipe, Where Q is the flow rate per unit time, r is the pipe radius, ΔP is the pressure drop, η is the dynamic viscosity of the fluid, and l is the pipe length. In this application, ΔP = P1 - P2, converting the Poiseuille formula to:

[0039] like Figure 2 and Figure 6 As shown, during use, the pressure sensor at the distal end of the ultrasonic guidewire is initially located proximal to the thrombus and has not yet passed through it. At this time, the pressure value P1 is measured. After the distal end of the ultrasonic guidewire passes through the thrombus, the pressure value P2 is measured at the distal end of the ultrasonic guidewire. Within a section of blood vessel, the blood flow Q is consistent at the same time. However, due to the presence of thrombus in the vessel, the value of P2 is small and the value of ΔP is large. As the thrombus is gradually dissolved, the value of P2 gradually increases. The distal end of the ultrasonic guidewire monitors the value of P2 in real time. When the value of P2 no longer changes, it indicates that the thrombus at this location in the same direction has been completely dissolved. The signal is transmitted to the host computer, which controls the ultrasonic guidewire to rotate a certain angle, such as 90°, and continues to monitor the value of P2 in real time. When the value of P2 remains unchanged after a total rotation of 360°, it indicates that the thrombus in this section of the vessel has been completely dissolved. The ultrasonic guidewire is then advanced distally, and the above process is repeated until the thrombus in the entire section of the vessel has been completely dissolved.

[0040] Optical imaging equipment and acoustic imaging equipment collect image changes of thrombus morphology and send them to the host. The host judges the extent of thrombolysis based on the returned images and whether there are any areas that have not been dissolved. Then, based on the position information on the image, the host controls the speed, angle and frequency of the ultrasonic guidewire rotation.

[0041] Both intravascular optical imaging equipment and acoustic imaging equipment are devices that have been disclosed in the prior art. The present invention uses the image information they transmit back to determine the location, size, and morphology of the thrombus. In the circumferential direction, if it is detected that there is more thrombus on one side and less on the other side, the rotation angle of the ultrasonic guide wire is controlled so that the transducer can be aligned with the side with more thrombus and work.

[0042] Beneficial effects

[0043] (1) The present invention provides an invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter. As the thrombus dissolves, the blood pressure changes. The pressure sensor feeds back the change to the host, which controls the ultrasonic guidewire to rotate at a certain speed, making the thrombolysis process more stable and controllable.

[0044] (2) The present invention provides an interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter. As the thrombus dissolves, the thrombus morphology changes. The optical imaging device and the acoustic imaging device feed back the changes to the host computer, which controls the ultrasonic guide wire to rotate at a certain speed, thereby effectively controlling the degree of thrombolysis.

[0045] (3) The present invention is an interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, which has a 360-degree ultrasonic irradiation function. The ultrasonic guide wire of the ultrasonic transducer is driven by a driving device to rotate to achieve a 360-degree ultrasonic irradiation function, ensuring that the thrombus in the entire blood vessel is completely dissolved. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 and Figure 2 This is a schematic structural diagram of the invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter of the present invention;

[0047] Figure 3 It is a front view of the ultrasonic transducer of the present invention;

[0048] Figure 4 is an axial cross-sectional view of the catheter body of the present invention;

[0049] Figure 5 Schematic cross-sectional view of a catheter main body section with a delivery port on the wall according to the present invention;

[0050] Figure 6 It is a control logic schematic diagram of the present invention;

[0051] Among them, 1-catheter body, 2-ultrasonic guidewire, 3-ultrasonic transducer, 4-monitoring device, 5-condensate inflow channel, 6-condensate outflow channel, 7-straight gear, 8-servo motor with gear, 9-delivery port, 10-housing. DETAILED DESCRIPTION

[0052] Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiments are only used to illustrate the present invention and are not used in limiting the scope of the present invention.In addition, should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms fall equally within the scope limited by the appended claims of the application.

[0053] An interventional intelligent 360-degree ultrasound radiation intravascular thrombolysis catheter, such as Figures 1 to 5 As shown, it includes a catheter body 1, an ultrasonic guidewire 2, an ultrasonic transducer 3, a condensate delivery device, a host, a temperature sensor, a driving device and a monitoring device 4;

[0054] like Figure 4 and Figure 5 As shown, the outer wall of the catheter body 1 is provided with one or more delivery ports 9 for delivering drugs, and the diameter of the delivery ports 9 is 0.01-0.1 mm;

[0055] like Figure 2 As shown, the ultrasonic guidewire 2 passes through the catheter body 1 and both ends of the ultrasonic guidewire 2 are located outside the catheter body 1;

[0056] like Figure 3 As shown, the ultrasonic transducer 3 (working frequency 0.5-20 MHz) is a laminar structure located inside the catheter body 1 and fixedly connected to the ultrasonic guidewire 2. When there are two or more ultrasonic transducers 3, the ultrasonic transducers 3 are spaced apart along the length direction of the ultrasonic guidewire 2, and the thickness directions of different ultrasonic transducers 3 are parallel to each other.

[0057] like Figure 2 As shown, the tail of the catheter body 1 is provided with a condensate inflow channel 5, and the head is provided with a condensate outflow channel 6; the condensate inflow channel 5 is connected to the condensate delivery device, and the condensate delivery device is connected to the host; the host is located outside the catheter body;

[0058] The temperature sensor is fixed to the head of the ultrasonic guidewire 2 or the head of the catheter body 1, and is used to detect the temperature of the condensate and blood mixture and transmit the information to the host. The host is used to receive the information sent by the temperature sensor and control the rate at which the condensate flows out of the catheter body 1 through the condensate delivery device to ensure that the temperature of the condensate and blood mixture does not exceed 40°C.

[0059] like Figure 1As shown, the driving device is used to drive the ultrasonic guidewire 2 to rotate around its own central axis, and the maximum rotation angle is 360 degrees; the driving device is composed of a spur gear 7 and a servo motor with a gear 8. The spur gear 7 is fixedly sleeved on the tail of the ultrasonic guidewire 2, and the gear in the servo motor with a gear is fixedly sleeved on the motor shaft and meshes with the spur gear 7; the meshing part of the spur gear 7 and the servo motor with a gear 8 is encapsulated by a housing 10, so that the gear structure is always inside, which is conducive to protecting this structure;

[0060] The host is also used to receive and process information sent by the monitoring device, and to control the rotation of the ultrasonic guidewire through the driving device to fully dissolve the thrombus;

[0061] like Figure 1 As shown, the monitoring device 4 is fixed to the head of the ultrasonic guidewire 2 or the head of the catheter body 1; the monitoring device 4 is a pressure sensor, an optical imaging device or an acoustic imaging device; the pressure sensor is used to monitor the blood pressure in real time and send it to the host, and the optical imaging device and the acoustic imaging device are used to monitor the thrombus morphology in real time and send it to the host;

[0062] When the monitoring device 4 is a pressure sensor, Figure 6 As shown, the host controls the movement of the ultrasonic guidewire 2 according to the following process:

[0063] (1) Determine whether the blood pressure monitored by the pressure sensor continues to change. If so, no adjustment is made; otherwise, proceed to the next step;

[0064] (2) Determine whether the time for which the blood pressure monitored by the pressure sensor remains constant exceeds a min. If so, proceed to the next step; otherwise, return to step (1); the value range of a is 0.1-5;

[0065] (3) Control the ultrasonic guide wire 2 to rotate clockwise around its own central axis by b degrees through the driving device, and determine whether the total rotation angle of the ultrasonic guide wire 2 around its own central axis is less than 360 degrees. If so, return to step (1); otherwise, proceed to the next step; the value range of b is 30-90;

[0066] (4) Determine whether the blood pressure monitored by the pressure sensor continues to change. If so, no adjustment is made; otherwise, proceed to the next step;

[0067] (5) Determine whether the time for which the blood pressure monitored by the pressure sensor remains constant exceeds a min. If so, proceed to the next step; otherwise, return to step (4);

[0068] (6) After the doctor manually controls the ultrasonic guidewire 2 to advance c mm in the axial direction, the process returns to step (1); the value range of c is 1-20;

[0069] When the monitoring device 4 is an optical imaging device or an acoustic imaging device, the host controls the movement of the ultrasonic guidewire 2 according to the following process:

[0070] (1) Determine whether the thrombus distribution in the circumferential direction of the blood vessel is uniform. If not, proceed to the next step; otherwise, proceed to step (3);

[0071] (2) Determine whether the front of the ultrasonic transducer 3 is aligned with the portion with the most thrombus. If so, return to step (1); otherwise, control the ultrasonic guide wire 2 to rotate around its own central axis by a certain angle through the driving device so that the front of the ultrasonic transducer 3 is aligned with the portion with the most thrombus, and then return to step (1);

[0072] (3) After the doctor manually controls the ultrasonic guidewire 2 to advance c mm in the axial direction, the process returns to step (1); the value range of c is 1-20.

Claims

1. An interventional intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter, characterized by: It includes a catheter body, an ultrasonic guidewire, an ultrasonic transducer, a monitoring device, a driving device and a host; The ultrasonic guidewire passes through the catheter body and both ends of the ultrasonic guidewire are located outside the catheter body; The ultrasonic transducer is located in the catheter body and is fixedly connected to the ultrasonic guidewire; the number of the ultrasonic transducers is one or more, and when the number is two or more, they are spaced apart along the length direction of the ultrasonic guidewire; The monitoring device is fixed to the head of the ultrasound guidewire or the head of the catheter body. The monitoring device is an optical imaging device or an acoustic imaging device. The optical imaging device and the acoustic imaging device are used to monitor the thrombus morphology in real time and send it to the host. The host controls the movement of the ultrasound guidewire according to the following process: (1) Determine whether the thrombus distribution in the circumferential direction of the blood vessel is uniform. If not, proceed to the next step; otherwise, proceed to step (3); (2) determining whether the front of the ultrasonic transducer is aligned with the portion with the most thrombus; if so, returning to step (1); otherwise, controlling the ultrasonic guidewire to rotate around its own central axis by a certain angle through a driving device so that the front of the ultrasonic transducer is aligned with the portion with the most thrombus, and then returning to step (1); (3) After the doctor manually controls the ultrasonic guidewire to advance c mm in the axial direction, the process returns to step (1); the value of c ranges from 1 to 20; The driving device is connected to the tail of the ultrasonic guidewire; the driving device is used to drive the ultrasonic guidewire to rotate around its own central axis, and the maximum rotation angle is 360 degrees; The host is located outside the catheter body and is used to receive and process information sent by the monitoring device, and control the rotation of the ultrasonic guidewire through the driving device to fully dissolve the thrombus.

2. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 1, characterized in that: The outer wall of the catheter body is provided with one or more delivery ports, each of which has a diameter of 0.01-0.1 mm.

3. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 1, characterized in that: It also includes a condensate delivery device; the tail of the catheter body is provided with a condensate inflow channel, and the head is provided with a condensate outflow channel; The condensate inflow channel is connected to the condensate delivery device, and the condensate delivery device is connected to the host.

4. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 3, characterized in that: It also includes a temperature sensor; the temperature sensor is fixed to the head of the ultrasonic guidewire or the head of the catheter body; the temperature sensor is used to detect the temperature of the condensate and blood mixture and send it to the host; the host is also used to receive the information sent by the temperature sensor and control the rate at which the condensate flows out of the catheter body through the condensate conveying device to ensure that the temperature of the condensate and blood mixture is not higher than 40°C.

5. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 1, characterized in that: The operating frequency of the ultrasonic transducer is 0.5-20MHz.

6. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 1, characterized in that: The ultrasonic transducer has a layer structure. When there are two or more ultrasonic transducers, the thickness directions of different ultrasonic transducers are parallel to each other.

7. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 1, characterized in that: The driving device consists of a spur gear and a servo motor with a gear. The spur gear is fixedly sleeved on the tail of the ultrasonic guide wire, and the gear in the servo motor with a gear is fixedly sleeved on the motor shaft and meshes with the spur gear.

8. The invasive intelligent 360-degree ultrasonic radiation intravascular thrombolysis catheter according to claim 1, characterized in that: The monitoring device is a pressure sensor, which is used to monitor blood pressure in real time and send the information to the host. The host controls the movement of the ultrasonic guidewire according to the following process: (1) Determine whether the blood pressure monitored by the pressure sensor continues to change. If so, no adjustment is made; otherwise, proceed to the next step; (2) Determine whether the time for which the blood pressure monitored by the pressure sensor remains constant exceeds a min. If so, proceed to the next step; otherwise, return to step (1); the value range of a is 0.1-5; (3) Control the ultrasonic guidewire to rotate b degrees clockwise around its own central axis through the driving device, and determine whether the total angle of rotation of the ultrasonic guidewire around its own central axis is less than 360 degrees. If so, return to step (1); otherwise, proceed to the next step; the value range of b is 30-90; (4) determining whether the blood pressure monitored by the pressure sensor continues to change, and if so, making no adjustment; Otherwise, proceed to the next step; (5) Determine whether the time for which the blood pressure monitored by the pressure sensor remains constant exceeds a min. If so, proceed to the next step; otherwise, return to step (4); (6) After the doctor manually controls the ultrasonic guidewire to advance c mm axially, return to step (1); the value range of c is 1-20.

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