A multifunctional Chinese medicine composition for treating skin and mucosal ulcers and its preparation method

Abstract

The invention discloses a multifunctional Chinese medicine composition for treating skin and mucosal ulcers and a preparation method thereof. The composition is prepared from the following herbal raw materials in proportion by weight: 15-25 parts of cattle hoof nail, 10-20 parts of pig hoof nail, 9-16 parts of holly leaves, 8-15 parts of privet leaves, 10-15 parts of maple balsam, 6-10 parts of wax ash, 12-20 parts of scutellaria baicalensis, 13-18 parts of red aconite, 7-12 parts of haiercha and 14-21 parts of calamine. The invention is characterized in that three groups of drugs are skillfully used in the prescription, which can give full play to the advantages of drug synergy and enhanced efficacy. The pharmacology includes the functions of clearing away heat and detoxifying, relieving inflammation and relieving pain, cooling blood and relieving swelling, promoting blood circulation and promoting muscle growth, and collecting dampness and consolidating sores. The invention is used to treat skin and mucosal ulcer diseases such as recurrent oral ulcers, oral traumatic ulcers, lower limb ulcers (ecthyma), burns caused by water or fire, cervical erosion, genital ulcers, bedsore-type ulcers, diabetic ulcers that do not close for a long time, and itchy skin disease exudative inflammation. The raw material drug of the invention is rich in source, simple in preparation process, significant in efficacy, and has no toxic and side effects, and is suitable for use by different groups of people.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a multifunctional traditional Chinese medicine composition for treating skin and mucosal ulcers and a preparation method thereof. Background Art

[0002] At present, in terms of traditional Chinese medicine treatment, there are many drugs and formulas for treating a single case or disease, but there are very few that can treat several diseases with the same formula or medicine. For example, there are dozens of Chinese patent medicines for treating oral ulcers, but the effect of using these medicines to treat similar skin disease ulcers such as lower limb ulcers is not ideal; there is also a phenomenon that in order to cater to the trend of one prescription being able to treat multiple diseases, dozens of medicines are mixed together in a net-like configuration, not to mention the antagonism between the drugs. The resulting waste of resources, cumbersome preparation, increased costs and burden on patients must be taken seriously. In fact, people often encounter two or more similar diseases in daily life, such as ulcerative diseases of the same skin and mucous membranes. Although the causes are different, they also have the same commonality, that is, although the skin and mucous membranes are bounded, they are homologous, so the treatment principles are also regular. For this reason, it is particularly necessary to invent a Chinese herbal medicine formula and preparation to treat multiple ulcerative diseases of the skin and mucous membranes at the same time. . Summary of the invention

[0003] In order to solve the above existing key problems, the present invention provides a multifunctional Chinese medicine composition for treating skin and mucosal ulcers and a preparation method thereof.

[0004] The present invention is achieved through the following technical solutions:

[0005] A multifunctional Chinese medicinal composition for treating skin and mucosal ulcers is prepared from the following herbal raw materials in proportions by weight: 15-25 parts of ox hoof nails, 10-20 parts of pig hoof nails, 9-16 parts of holly leaves, 8-15 parts of privet leaves, 10-15 parts of maple balsam, 6-10 parts of wax ash, 12-20 parts of scutellaria baicalensis, 13-18 parts of red aconite seeds, 7-12 parts of haiercha and 14-21 parts of calamine.

[0006] The raw materials of the composition are further preferably: 22 parts of ox hoof nail, 16 parts of pig hoof nail, 15 parts of holly leaves, 13 parts of privet leaves, 12 parts of maple resin, 7 parts of wax wax, 14 parts of scutellaria baicalensis, 13 parts of red aconite, 8 parts of baicalensis, and 17 parts of calamine.

[0007] The present invention accordingly provides a method for preparing the above-mentioned multifunctional Chinese medicine composition for treating skin and mucosal ulcers, comprising the following steps:

[0008] ① Weigh the raw materials according to the above preferred weight ratio;

[0009] ② Saw the cattle hoof nail into small pieces and place them in the muffle furnace, adjust the heating temperature to 350℃, and when the furnace temperature reaches the set value, keep the constant temperature for 5 minutes or turn off the furnace when brown smoke comes out of the observation hole. Wait for a while, open the furnace door and take out the carbonized cattle hoof nail. The carbonized cattle hoof nail is not black or gray, but brown in color;

[0010] ③ The processing process of pig hoof nail is the same as that of cattle hoof nail, the only difference is that the carbonization temperature is set at 300℃;

[0011] ④ Calamine is prepared by calcination and quenching method. Place the calamine in a muffle furnace and set the heating temperature to 800℃. When the furnace temperature reaches the preset value, keep calcining for 5 minutes, or turn off the machine when the calamine is red through the observation hole. When the furnace turns dark red through the observation hole of the furnace door, open the furnace door, take out the calamine that has been calcined, put it into the vinegar solution while it is hot, and quench it for 10 minutes, then dry it for later use.

[0012] ⑤ Mix the carbonized ox hoof nail, pig hoof nail, calcined calamine, dried maple resin, insect wax and baby tea and grind them into powder for later use;

[0013] ⑥ Chop up holly leaves, privet leaves, safflower and red medicine seeds, put them in a sealed enamel jar, add 70% alkaline ethanol to submerge the medicinal materials, soak for 7 days, stir once in the morning and evening every day, then filter out the residue and collect the extract; add 70% alkaline ethanol to the residue for secondary soaking for 3 days, stir once in the morning and evening every day, filter out the residue again and squeeze out the residue, collect the secondary extract and combine it with the first extract; take the filtrate to recover ethanol at low temperature to obtain a fluid extract; place the fluid extract on a water bath and evaporate and concentrate it into a dry extract, and each gram of this dry extract is equivalent to 4 grams of the original drug;

[0014] ⑦ Combine the dry extract of item ⑥ and the mixed powder of item ⑤, grind them together, pass through a 200-mesh sieve to obtain the multifunctional ulcer powder. After routine sterilization, divide them into squeeze spray bottles for later use, 10 grams per bottle.

[0015] Description of the characteristics of the composition: The formula contains three pairs of medicines, ox hoof nail and pig hoof nail, holly leaf and privet leaf, maple resin and wax wax. The use of the medicines can give full play to the synergistic effect and further improve the efficacy.

[0016] Diseases treated by the composition: The prepared multifunctional ulcer powder can treat common skin and mucous membrane ulcer diseases including exudative and ulcerative diseases.

[0017] Pharmacology and function of Chinese herbal medicine used in the present invention:

[0018] Ox hoof nail: Contains keratin, cool in nature, salty and bitter in taste. The coolness can clear away heat, the saltiness can reduce swelling, and the bitterness can dry out dampness, so it can absorb moisture and heal sores, and is suitable for treating wet sores, ulcers and pain. Both "Compendium of Materia Medica" and "Hai Fang Fang" have records of using burnt ox hoof nail ash to treat ecthyma.

[0019] Pig's hoof nail: mainly contains keratin, peptides, amino acids, steroid compounds and inorganic salts; it is cold and salty in nature, and has the effects of clearing away heat and detoxification, resolving phlegm and relieving cough, stopping bleeding, removing dead tissue and promoting tissue regeneration; it can treat oral sores, ulcers and boils, promote the growth of new flesh, and accelerate the healing of ulcers. It is a complementary medicine with cattle hoof nail, and they complement each other's strengths and have a good synergistic effect;

[0020] Holly leaves: bitter and astringent, contain two antibacterial ingredients, protocatechuic acid and flavonoids, and volatile oils; have the functions of clearing away heat and detoxifying, cooling blood and stopping bleeding, and anti-inflammatory and healing sores; treat skin and mucosal ulcers (including ecthyma), skin eczema, and the initial stage of heat-toxic sores and boils, especially good at treating burns caused by water or fire, and also treats a variety of infectious diseases; have a wide anti-inflammatory spectrum and significant effects, and have killing and inhibitory effects on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, and Escherichia coli. The Song Dynasty's "Illustrated Materia Medica" records that holly leaves ground into powder and applied externally can treat scars; "Compendium of Materia Medica" says that it "tonifies the skin";

[0021] Ligustrum lucidum leaf: cool in nature, contains eugenol, tannic acid, and artemisia annua combination; clears away heat, reduces inflammation, relieves pain, and promotes tissue regeneration; treats boils, ulcers, burns, stomatitis, and traumatic bleeding; "Compendium of Materia Medica" records that it can treat various malignant ulcers, ulcers, and oral ulcers; it can also resist Staphylococcus aureus, pus aeruginosa, and Escherichia coli. It is a pair of medicines with holly, which complement each other and are more powerful;

[0022] Liquidambar resin: It tastes pungent, slightly bitter and has a neutral nature. It contains a variety of alcoholic acids, keto acids and volatile oils. It is bitter and cools blood heat, treats poisonous sores, and has a sticky and greasy nature to remove wind and dryness. Therefore, it can activate blood circulation, dredge meridians, detoxify, promote tissue regeneration, and cool blood and stop bleeding. It is often used to treat carbuncle at the beginning or rupture, and ecthyma that does not heal for a long time.

[0023] Insect wax: sweet in taste and warm in nature, composed of macromolecular esters, acids, and alcohols; sweet can nourish blood and replenish the middle, warm can dredge meridians and activate collaterals, so it can activate blood circulation and stop bleeding, relieve pain and promote tissue regeneration, and is used for wound bleeding, hematuria, and long-term ulcers; it can also be used as an excipient and lubricant. Borrowing the collateral-drying and detoxifying effects of maple resin, the effects of activating blood circulation and relieving pain, promoting tissue regeneration and healing ulcers are even better;

[0024] Jiubiying: bitter and cold, contains flavonoids, tripteroside, and tannins; can resist Staphylococcus aureus, beta-hemolytic Streptococcus, Pseudomonas aeruginosa, and Shigella dysenteriae; can clear away heat and detoxify, promote dampness and relieve pain, and can treat colds and fevers, tonsil inflammation, sore throats, acute gastroenteritis, gastric and duodenal ulcers, burns, and can be used to resist (suppurative) infections and infections of the upper respiratory tract, burns, and postoperative infections;

[0025] Red medicine seed: bitter, slightly astringent, cool in nature, contains rhubarb, rhubarb glycosides and anthraquinones, can resist Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Shigella dysenteriae, pharmacologically antibacterial and anti-inflammatory, cooling blood and stopping bleeding, relieving spasms and relieving pain, and promoting ulcer healing; can treat tonsil inflammation, gastritis, enteritis, upper respiratory tract, trauma, urinary tract infection, cellulitis, furunculosis;

[0026] Haier Tea: bitter, astringent, cool in nature, contains catechin tannin and gallic acid tannin, which can activate blood circulation, promote muscle growth, absorb moisture and heal sores. It is mainly used to treat ulcers, eczema, mouth sores and bedsores; it has a broad antibacterial spectrum and can effectively kill or inhibit Staphylococcus aureus, beta-hemolytic Streptococcus, Pseudomonas aeruginosa, Proteus, Shigella dysenteriae and a variety of skin fungi;

[0027] Calamine: Its ingredient is zinc carbonate, which decomposes into zinc oxide after calcination. It has the functions of drying dampness, astringing, antiseptic, relieving itching and promoting tissue regeneration. It is mainly used to treat ulcers that do not heal, skin eczema, and mouth sores. It can dissolve and absorb wound secretions and protect the skin and mucous membranes from inflammation. After calcination, it is quenched with vinegar to enhance the function of astringing sores and promoting tissue regeneration.

[0028] The functions of the above-mentioned drugs include clearing away heat and detoxifying, relieving inflammation and pain, cooling blood and reducing swelling, promoting blood circulation and promoting tissue regeneration, and absorbing moisture and healing sores. The pharmacology and treatment principles have covered the range of common skin and mucosal ulcer diseases.

[0029] The beneficial effects of the present invention are as follows: it is mainly based on herbs, has abundant sources of medicine, low cost and simple preparation; the use of medicines is synergistic and the therapeutic effect is enhanced; although the medicinal taste is not much, it can indeed treat a variety of diseases, and is a veritable model of one prescription treating multiple diseases; it can treat skin and mucosal ulcer diseases such as recurrent oral ulcers, oral traumatic ulcers, lower limb ulcers (ecthyma), burns caused by water or fire below degree II, cervical erosion, genital ulcers, bedsore-type ulcers, diabetic ulcers that do not heal for a long time, and itchy skin diseases, exudative inflammation and other similar diseases. The prescription has a significant therapeutic effect on the above-mentioned skin and mucosal ulcer diseases, with an effective rate of 100% and an average cure rate of 96%, and has no toxic side effects and no contraindications, and is suitable for use by most people. DETAILED DESCRIPTION

[0030] The technical solution of the present invention is explained in detail below through specific embodiments, but this cannot be used as a limitation of the content of the present invention; the so-called dialectical addition and subtraction or flexible application obtained by technicians in this field without creative work is still within the scope of protection of the present invention.

[0031] Example 1. A multifunctional Chinese medicinal composition for treating skin and mucosal ulcers, composed of the following herbal raw materials in proportions by weight: 15-25 parts of ox hoof nail, 10-20 parts of pig hoof nail, 9-16 parts of holly leaves, 8-15 parts of privet leaves, 10-15 parts of maple balsam, 6-10 parts of wax wax, 12-20 parts of scutellaria baicalensis, 13-18 parts of red medicine seeds, 7-12 parts of baby tea, and 14-21 parts of calamine.

[0032] The preferred proportion of the raw materials by weight is: 22 parts of ox hoof nail, 16 parts of pig hoof nail, 15 parts of holly leaves, 13 parts of privet leaves, 12 parts of maple resin, 7 parts of wax ash, 14 parts of scutellaria baicalensis, 13 parts of red medicine seeds, 8 parts of baby tea, and 17 parts of calamine.

[0033] A method for preparing a multifunctional Chinese medicine composition for treating skin and mucosal ulcers comprises the following steps:

[0034] ① Weigh the raw materials according to the above preferred weight ratio;

[0035] ② Saw the cattle hoof nail into small pieces and place them in the muffle furnace, adjust the heating temperature to 350℃, and when the furnace temperature reaches the set value, keep the constant temperature for 5 minutes or turn off the furnace when brown smoke comes out of the observation hole. Wait for a while, open the furnace door and take out the carbonized cattle hoof nail. The carbonized cattle hoof nail is not black or gray, but brown in color;

[0036] ③ The processing process of pig hoof nail is the same as that of cattle hoof nail, the only difference is that the carbonization temperature is set at 300℃;

[0037] ④ Calamine is prepared by calcination and quenching method. Calamine is placed in a muffle furnace for calcination. The heating temperature is set to 800℃. When the furnace temperature reaches the preset value, keep calcining for 5 minutes, or turn off the machine when the calamine is seen to be red through the observation hole. When the furnace door observation hole shows that the furnace turns dark red, open the furnace door, take out the calcined calamine while it is hot, put it into the vinegar solution for quenching for 10 minutes, and bake it dry for later use;

[0038] ⑤ Mix the carbonized ox hoof nails, pig hoof nails, processed calamine, dried maple resin, insect wax and baby tea together and grind into powder for later use;

[0039] ⑥ Chop up holly leaves, privet leaves, safflower and red medicine seeds, put them in a sealed enamel jar, add 70% alkaline ethanol to submerge the medicinal materials, soak for 7 days, stir once in the morning and evening every day, then filter out the residue and collect the extract; add 70% alkaline ethanol to the residue for secondary extraction for 3 days, stir once in the morning and evening every day, filter out the residue again and squeeze out the residue, collect the secondary extract and combine it with the first extract; take the filtrate to recover ethanol at low temperature to obtain a fluid extract; place the fluid extract on a water bath and evaporate and concentrate it into a dry extract, and 1 gram of this dry extract is equivalent to 4 grams of the original drug;

[0040] ⑦ Combine the dry extract of item ⑥ and the mixed powder of item ⑤, grind them together, pass through a 200-mesh sieve to obtain the multifunctional ulcer powder. After routine sterilization, divide them into squeeze spray bottles for later use, 10 grams per bottle.

[0041] The above preparation instructions show that the equipment for carbonization and calcination in steps ②③④ is a medical muffle furnace, which can adjust and maintain a constant temperature, especially for well controlling the degree of carbonization of medicinal materials, can simplify procedures, does not require frequent operations, and greatly shortens the carbonization time.

[0042] Continuing to explain: In step ⑥, the pH value of the 70% alkaline ethanol extract is 8.5-9.0, and the regulator is 10% sodium carbonate solution. Under this condition, the active ingredients contained in the above four raw materials such as organic acids, flavonoids, glycosides, and anthraquinones are easily dissolved and the stability is increased, and alkali-insoluble impurities can also be removed.

[0043] Continue to explain: Step ④ is to quench the calamine with vinegar after calcining it, the purpose is to enhance its effect of healing sores and promoting tissue regeneration. In addition, vinegar itself has the effect of eliminating carbuncles and treating sores and tinea.

[0044] Continuing explanation: The finished product obtained in step ⑦ is a kind of ulcer powder (hereinafter referred to as ulcer powder). For cases with exudative lesions of the skin and mucous membranes, the dry powder can be applied directly, while for diseases without exudative tendency of the skin and mucous membranes, sesame oil or honey can be added as appropriate, see the next item.

[0045] Example 2. First heat sesame oil to about 50°C, boil honey in water to about 50°C, add appropriate amount of ulcer powder, stir into a paste, and apply it on the vertical skin surface without sliding down (the same below as the ulcer cream).

[0046] Usage: For mucosal ulcers, ulcer powder is generally used. For skin ulcers with exudation, ulcer powder is used. For ulcers without exudation tendency or with astringent scabs, ulcer ointment is used. The number of times of medication per day can be determined as appropriate, and one course of treatment is three days.

[0047] Clinical application examples

[0048] Mr. Li, male, 48 years old, complained of recurrent oral ulcers for 8 years, with an average recurrence of 3-4 times per year, 6-10 ulcers, and a duration of 8-14 days. He was prone to occur on the lips, cheek mucosa, upper palate, and around the tongue, with typical "red, yellow, concave, and painful" characteristics. He had to gargle with 2% lidocaine diluted solution to relieve the pain before eating each time, which was very painful. He was cured after two courses of treatment with this powder.

[0049] Tang, male, 57 years old, had chronic ulcers in the lower part of the calf (tenthorax) caused by varicose veins of the lower limbs. The symptoms included superficial ulcers with irregular edges and bright red flesh-colored sores. Eczema occurred in the places where the hands had been scratched, and the sores broke spontaneously and oozed. The first ulcer site showed signs of infection, and the secondary site was red, swollen and painful. There were no other complications, which were typical early manifestations. Before treatment, the patient was cleaned and disinfected with hydrogen peroxide, and the secretions were removed. Then the entire affected area was sprayed with ulcer powder, bandaged with gauze, and the dressing was changed once a day. After three days, the ulcer surface shrank and there was no tendency for exudation. The treatment was changed to ulcer ointment, and the wound began to scab after six days.

[0050] Liu, female, 32 years old, was scalded by boiling water on the inner side of her right forearm, with an area of ​​5×15 cm. Blisters formed on the skin surface of the wound, the bottom of the wound was very red and edematous, the wound surface was allergic and extremely painful, and the local temperature was increased. She was diagnosed with superficial second-degree burns. During treatment, the wound was first cleaned with normal saline. For those with large blisters, 1% chlorhexidine was used for cleaning and disinfection. The blister fluid was drained out at the lower part of the blister with a syringe. The wound was then cleaned with saline, wiped dry, and ulcer ointment was applied to the wound. For those with first and second degree burns, the medicine can be applied for 10 minutes to moisturize and relieve pain. For those without infection, the wound can be exposed to dryness. The medicine should be applied twice a day for the first three days, and once a day thereafter. Most of them are cured in one week.

[0051] Chen Moumou, female, 42 years old, suffered from cervical erosion for three months, complaining of heavy vaginal discharge, lower abdominal distension and pain, vaginal stinging accompanied by bleeding during intercourse, back pain, and bladder irritation. During each treatment, 1 / 1000 potassium permanganate was used to flush the vagina, and the cervical secretions were cleared before applying the medicine. First, ulcer cream was applied on the cotton ball, and then the cotton ball was wrapped with gauze, and a 15-cm thread was left after locking the mouth. Then, the gauze ball was dipped in ulcer powder and stuffed into the cervix, and removed at night. After three courses of treatment, the cervical erosion was cured.

Claims

1. A Chinese medicine composition for treating skin and mucosal ulcers, characterized in that: The composition is prepared from the following raw materials by weight: 15-25 parts of cattle hoof nail, 10-20 parts of pig hoof nail, 9-16 parts of holly leaves, 8-15 parts of privet leaves, 10-15 parts of maple balsam, 6-10 parts of wax ash, 12-20 parts of scutellaria baicalensis, 13-18 parts of red aconite, 7-12 parts of haiercha and 14-21 parts of calamine.

2. A Chinese medicine composition for treating skin and mucosal ulcers according to claim 1, characterized in that: The composition is prepared from the following raw materials by weight: 22 parts of cattle hoof nail, 16 parts of pig hoof nail, 15 parts of holly leaves, 13 parts of privet leaves, 12 parts of maple resin, 7 parts of wax ash, 14 parts of scutellaria baicalensis, 13 parts of red aconite, 8 parts of haier tea, and 17 parts of calamine.

3. A method for preparing a Chinese medicine composition for treating skin and mucosal ulcers according to claim 1 or 2, characterized in that: The following steps are involved: ① Weigh the raw materials according to the above preferred weight ratio; ② Saw the cattle hoof nail into small pieces and place them in a muffle furnace for carbonization, adjust the heating temperature to 350°C, and when the furnace temperature reaches the set value, keep the constant temperature for 5 minutes or turn off the furnace when brown smoke comes out of the observation hole, wait for a while, open the furnace door and take out the carbonized cattle hoof nail. The carbonized cattle hoof nail is not black or gray, but brown in color as a whole; ③ The processing process of pig hoof nail is the same as that of cattle hoof nail, the only difference is that the carbonization temperature is set to 300°C; ④ Calamine is prepared by calcination and quenching method. Place calamine in a muffle furnace and set the heating temperature to 800℃. When the furnace temperature reaches the preset value, keep calcining for 5 minutes, or turn off the machine when the calamine is red through the observation hole. When the furnace turns dark red through the observation hole of the furnace door, open the furnace door, take out the calcined calamine, put it into the vinegar solution while it is hot and quench for 10 minutes, and bake it dry for later use; ⑤ Mix the carbonized cattle hoof nails, pig hoof nails, calcined calamine, dried maple resin, insect wax and baby tea together and grind them into powder; ⑥ Mix holly leaves, privet leaves, and rescue Chop the bing and red medicine seeds, put them in a sealed enamel cylinder, add 70% alkaline ethanol to submerge the medicine, and extract for 7 days, stirring once in the morning and evening every day, then filter out the residue, collect the extract, and add 70% alkaline ethanol to the residue for secondary extraction for 3 days, stirring once in the morning and evening every day, filter out the residue again and squeeze out the residue, collect the secondary extract and combine it with the first extract, take the filtrate and recover ethanol at low temperature to obtain a fluid extract, put the fluid extract on a water bath and evaporate and concentrate it into a dry extract. Each gram of this dry extract is equivalent to 4 grams of the original drug; ⑦ Combine the dry extract of item ⑥ and the mixed powder of item ⑤, grind them together, pass through a 200-mesh sieve, and obtain a multifunctional ulcer powder. After routine sterilization, divide it into squeeze-type spray bottles for standby use, and each bottle contains 10 grams.

4. A method for preparing a Chinese medicine composition for treating skin and mucosal ulcers according to claim 3, characterized in that: The apparatus for carbonization and calcination in steps ②, ③ and ④ is a medical muffle furnace.

5. A method for preparing a Chinese medicine composition for treating skin and mucosal ulcers according to claim 3, characterized in that: In the step ⑥, the pH value of the 70% alkaline ethanol extract is 8.5-9.0, and the regulator is 10% sodium carbonate solution.

6. A method for preparing a Chinese medicine composition for treating skin and mucosal ulcers according to claim 3, characterized in that: In the step ④, the calamine is calcined and then quenched with vinegar, and the acidity of the vinegar is 5%.

7. A Chinese medicine composition for treating skin and mucosal ulcers according to claim 1, 2 or 3, characterized in that: The prepared ulcer powder is used to treat skin and mucous membrane ulcerative diseases, recurrent oral ulcers, chronic ulcers of the lower limbs, and genital ulcers.