A high throughput screening system

Abstract

The application discloses a high-throughput screening system. The screening system of the application comprises a feeding device, a reactor, a separation device, an analysis device and a control device. The feeding device is used for the selection and accurate metering of reaction solvents and reaction materials, the reactor is used for the reaction of the reaction solvents and the reaction materials, and the analysis device is used for the characterization of the reaction solvents, the reaction materials and products. The control device controls the stable operation of each system respectively, analyzes the data of the analysis system, obtains the optimal reaction condition, and the multifunctional continuous flow reactor is selected as the reactor, so that not only liquid phase reaction can be operated, but also gas-liquid-solid multiphase reaction can be realized through the solid catalyst, in addition, the increase of the pipe diameter is also helpful to the increase of the reaction flux, and the application has practical guiding significance for industrialization.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of organic synthesis chemistry, in particular to a high-throughput screening system. BACKGROUND

[0002] In the drug research and development, the scarcity of complex intermediates promotes the exploration of sub-milligram reaction optimization scheme, and high-throughput experiment (HTE) as an important tool of modern drug development and synthetic methodology workflow has attracted more and more attention. The main trend of high-throughput is to miniaturize the experiment, such as hole plate reaction and droplet microfluidic reaction, so as to save the cost consumption in the reaction process, in addition, the efficiency of HTE can be as high as thousands of reactions per day at the level of nanomoles by machine automation system.

[0003] At the beginning, high-throughput experiment in chemistry is to carry out many chemical reactions in hole plate at the same time in batches, but the hole plate intermittent high-throughput reaction has great limitations, such as the reaction solvent should have high boiling point and non-volatility (for example, DMSO), and in order to avoid solvent volatilization, the chemical reaction cannot be heated. In addition, the platform uses low-resolution mass spectrometry for analysis. The introduction of continuous flow technology largely overcomes the above limitations. High-throughput experiment and continuous flow technology are usually located at the two ends of the synthesis scale, the former contains hundreds of small-scale intermittent reactions for optimizing conditions, and the latter helps to efficiently batch produce single compounds in a wide range of temperature and pressure.

[0004] At present, although there are micro-reactor automatic experiment platforms for rapid chemical reaction and rapid screening, but because there is no online analysis system, it is impossible to realize high-throughput continuous screening work, and because the pipeline is small, it is only limited to the screening of reactions without solid participation, and the application range of the platform is limited. There are also some platforms that can realize high-throughput screening, but the reactor is a microfluidic chip, the channel size is usually in the sub-millimeter level (100-500um), and the flow rate is 1-100μL / min, while the channel size of the continuous flow micro-channel reaction industrialization system is in the millimeter level, therefore, the sub-millimeter channel is limited to scientific research, and is not convenient for industrialization.

[0005] In summary, there is no automatic reaction screening platform that combines the advantages of continuous flow process and high-throughput experiment. SUMMARY

[0006] Therefore, it is necessary to provide a high-throughput screening system which can increase the flow rate of the pipeline and support the continuous flow high-throughput screening system of multi-phase system application.

[0007] The present application provides a high-throughput screening system, comprising:

[0008] a feeding device;

[0009] a reactor connected with the feeding device, the feeding device being used to provide a pre-designed amount of reaction solvent and reaction material, and to deliver the reaction solvent and reaction material to the reactor, the reactor being used to provide the reaction solvent and the reaction material to react, to generate reaction product, and to mix into reaction liquid;

[0010] a separation device connected with the reactor, the reactor being further used to deliver the reaction liquid to the separation device, the separation device being used to separate the components of the reaction liquid;

[0011] an analysis device connected with the separation device, the separation device being further used to deliver the reaction liquid separated by the separation device to the analysis device, the analysis device being used to qualitatively and quantitatively analyze the components of the reaction liquid; and

[0012] a control device electrically connected with the feeding device, the reactor, the analysis device and the analysis device respectively, the control device being used to screen out the optimal reaction condition according to the analysis result of the analysis device.

[0013] Further, the reactor comprises:

[0014] a heater;

[0015] a first reaction component arranged in the heater, a catalyst being further arranged in the first reaction component, one end of the first reaction component being connected with the feeding device, and the other end of the first reaction component being connected with the separation device;

[0016] a second reaction component arranged at the outer periphery of the heater, one end of the second reaction component being connected with the feeding device, and the other end of the second reaction component being connected with the separation device; and

[0017] a light source component arranged at the outer periphery of the second reaction component.

[0018] Further, the first reaction component comprises a fixed bed and a reaction channel, the reaction channel and the catalyst being arranged in the fixed bed, the reaction channel being provided with a first reaction liquid inlet and a first reaction liquid outlet, the first reaction liquid inlet being connected with the feeding device, and the first reaction liquid outlet being connected with the separation device, the reaction liquid being able to enter the reaction channel through the first reaction liquid inlet, and to react under the catalysis of the catalyst, the reacted reaction liquid flowing out through the first reaction liquid outlet.

[0019] Further, the second reaction assembly comprises a reaction tube, the reaction tube is provided with a second reaction liquid inlet and a second reaction liquid outlet, the second reaction liquid inlet is connected with the feeding device, the second reaction liquid outlet is connected with the separation device, and the reaction tube is spirally wound on the outer periphery of the heater.

[0020] Further, the light source assembly comprises an LED light source and a cooling member, the LED light source is arranged on the cooling member and located between the cooling chamber and the reactor, the cooling member is provided with a containing cavity for containing cooling liquid, the cooling liquid is used for cooling the LED light source, and the cooling member is further provided with a cooling liquid inlet and a cooling liquid outlet.

[0021] Further, the feeding system comprises a multi-way valve, a degassing machine, a solvent pump, an automatic sampler, a quantitative ring, a first six-way valve and an ultraviolet detector, the multi-way valve, the degassing machine, the solvent pump, the automatic sampler, the quantitative ring, the first six-way valve and the ultraviolet detector are electrically connected with the control device, the multi-way valve is used for connecting a plurality of solvent bottles containing the reaction solvent, one end of the multi-way valve is connected with the degassing machine, the other end of the degassing machine is connected with the solvent pump, the first six-way valve is connected with the solvent pump, the quantitative ring and the ultraviolet detector respectively, the automatic sampler is connected with the quantitative ring, and the ultraviolet detector is connected with the reactor.

[0022] Further, the separation device is a liquid chromatography separation instrument, and the liquid chromatography separation instrument is provided with a column oven for keeping the reaction liquid at a constant temperature.

[0023] Further, the analysis device comprises a DAD detector and a mass spectrometry detector, and the DAD detector and the mass spectrometry detector are electrically connected with the control system.

[0024] Further, the material of the heater comprises at least one of copper and aluminum oxide.

[0025] The high-throughput screening system provided by the application is composed of a feeding device, a reactor, a separation device, an analysis device and a control device. The feeding device is used for providing a pre-designed amount of reaction solvent and reaction material, and the control device is used for controlling different reaction conditions (such as temperature, reaction time and reaction type). The separation device is used for continuous separation of the reaction liquid. The analysis device is used for characterization of the reaction solvent, the reaction material and the product. The control device controls the stable operation of each system and analyzes the data of the analysis device to obtain the optimal reaction condition. In addition, the continuous flow reactor is selected as the reactor, which has a larger pipe diameter, thereby increasing the flow rate of the reaction liquid and facilitating the guidance of industrialization. BRIEF DESCRIPTION OF DRAWINGS

[0026] In order to more clearly illustrate the technical solutions of the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained according to the structures shown in the drawings without any creative labor for those skilled in the art.

[0027] Figure 1 A structural schematic diagram of a high-throughput screening system according to an embodiment of the present application;

[0028] Figure 2 Another structural schematic diagram of a high-throughput screening system according to an embodiment of the present application;

[0029] Figure 3 A perspective view of a reactor according to an embodiment of the present application;

[0030] Figure 4 A sectional view of a reactor according to an embodiment of the present application;

[0031] Figure 5 A structural schematic diagram of a high-throughput screening system according to an embodiment of the present application; Figure 4 An enlarged view of A in FIG. 1;

[0032] Figure 6 A flow chart of a high-throughput screening method according to an embodiment of the present application;

[0033] Figure 7 A flow chart of a high-throughput screening method according to an embodiment of the present application;

[0034] Wherein:

[0035] 100, a feeding device; 110, a multi-way valve; 120, a degasser; 130, a solvent pump; 140, an automatic sampler; 150, a dosing ring; 160, a first six-way valve; 170, an ultraviolet detector; 180, a solvent bottle; 200, a reactor; 210, a heater; 221, a fixed bed; 222, a catalyst; 223, a first reaction liquid inlet; 224, a first reaction liquid outlet; 225, an inlet fastening screw; 226, an inlet sealing ring; 227, an inlet sealing screw; 2271, an inlet sealing member; 2272, an inlet sealing sleeve; 228, a filter screen plate; 229, an outlet fastening screw; 2291, an outlet sealing ring; 230, a second reaction assembly; 231, a second reaction liquid inlet; 232, a second reaction liquid outlet; 240, a light source assembly; 241, an LED light source; 242, a cooling member; 243, a cooling liquid inlet; 244, a cooling liquid outlet; 250, a heat-conducting copper plate; 300, a second six-way valve; 400, a separation device; 500, an analysis device; 600, a control device.

[0036] The objectives, functional characteristics and advantages of the present application will be further described with reference to the embodiments in combination with the accompanying drawings. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present application will be clearly and completely described in combination with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work under the premise that the present application falls within the scope of protection.

[0038] It should be noted that all the directionality indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present application are only used to explain the relative position relationship, movement condition, etc. between the components in a certain posture (as shown in the drawings), and if the certain posture changes, the directionality indications also change accordingly.

[0039] In addition, the description of "first", "second" and the like in the present application is only for the purpose of description, and cannot be understood as indicating or implying the relative importance of the indicated technical features or implicitly indicating the number of the indicated technical features. Therefore, the features defined with "first", "second" can explicitly or implicitly include at least one of the features. In addition, "and / or" throughout the text includes three solutions, taking A and / or B as an example, including A technical solution, B technical solution, and A and B simultaneously meet the technical solution; in addition, the technical solutions of each embodiment can be combined with each other, but it must be based on the realization of ordinary skilled in the art, when the combination of technical solutions appears contradictory or cannot be realized, it should be considered that the combination of technical solutions does not exist, nor within the scope of protection claimed by the present application.

[0040] In an embodiment, as Figure 1 and Figure 2As shown, a high-throughput screening system includes a feeding device 100, a reactor 200, a separation device 400, an analysis device 500 and a control device 600, the reactor 200 is connected with the feeding device 100, the feeding device 100 is used for providing a pre-designed amount of reaction solvent and reaction material, and conveying the reaction solvent and reaction material to the reactor 200, the reactor 200 is used for reaction of the reaction solvent and reaction material, generating reaction product, and mixing into reaction liquid, the separation device 400 is connected with the reactor 200, the reactor 200 is also used for conveying the reaction liquid to the separation device 400, the separation device 400 is used for separating the components of the reaction liquid, the analysis device 500 is connected with the separation device 400, the separation device 400 is also used for conveying the reaction liquid separated by the separation device 400 to the analysis device 500, the analysis device 500 is used for qualitative and quantitative analysis of the components of the reaction liquid, the control device 600 is electrically connected with the feeding device 100, the reactor 200, the analysis device 500 and the analysis device 500 respectively, and the control device 600 is used for screening the optimal reaction condition according to the analysis result of the analysis device 500.

[0041] Specifically, the feeding system includes a multi-way valve 110, a degasser 120, a solvent pump 130, an automatic sampler 140, a quantitative ring 150, a first six-way valve 160 and a UV detector 170, the multi-way valve 110, the degasser 120, the solvent pump 130, the automatic sampler 140, the quantitative ring 150, the first six-way valve 160 and the UV detector 170 are electrically connected with the control device 600, the multi-way valve 110 is used for connecting a plurality of solvent bottles 180, the solvent bottles 180 contain reaction solvent, the multi-way valve 110 is connected with one end of the degasser 120, the other end of the degasser 120 is connected with the solvent pump 130, the first six-way valve 160 is connected with the solvent pump 130, the quantitative ring 150 and the UV detector 170 respectively, the automatic sampler 140 is connected with the quantitative ring 150, and the UV detector 170 is connected with the reactor 200.

[0042] When working, the multi-way valve 110 is connected with different solvent bottles 180, and can be used to select different reaction solvents. Different solvents are selected by switching of the multi-way valve 110, and the corresponding solvents are extracted by using the solvent pump 130, and the gas generated in the process of extracting the solvents is removed by the degassing machine 120, and at the same time, the gas is prevented from entering the solvent pump 130, so that the stable operation of the solvent pump 130 is ensured. The solvent pump 130 can be used under high pressure or low pressure conditions, and under high pressure conditions, high accuracy and low delay time can be ensured. After the solvent passes through the first six-way valve 160, it enters the ultraviolet detector 170 and appears absorption, and then enters the liquid chromatography-mass spectrometry system when passing through the reactor 200, and appears another absorption. After the analysis and characterization are stable, the time difference between the absorptions of the two detectors is defined as the reaction time of the reaction, and the whole reaction system is cleaned by using the solvent. After the system solvent is stable, the automatic sampler 140 punches different reagents into the quantitative ring 150 of the first six-way valve 160 according to a specific ratio, and then the system controller switches the first six-way valve 160. The reaction reagents in the quantitative ring 150 are sent into the ultraviolet detector 170 by using the solvent, and ultraviolet absorption is generated, and then the reaction reagents flow into the continuous flow reactor 200 to react under different temperature conditions. After the reaction is completed, the reaction liquid enters the separation device 400 through the second six-way valve 300.

[0043] In the embodiment, please refer to Figures 3 to 5 The reactor 200 includes a heater 210, a first reaction assembly, a second reaction assembly 230 and a light source assembly 240. The first reaction assembly is arranged in the heater 210, and a catalyst 222 is further arranged in the first reaction assembly. One end of the first reaction assembly is connected with the feeding device 100, and the other end of the first reaction assembly is connected with the separation device 400. The second reaction assembly 230 is arranged on the outer periphery of the heater 210. One end of the second reaction assembly 230 is connected with the feeding device 100, and the other end of the second reaction assembly 230 is connected with the separation device 400. The light source assembly 240 is arranged on the outer periphery of the second reaction assembly 230. Specifically, the material of the heater 210 includes at least one of copper and aluminum oxide. Preferably, the material of the heater 210 is aluminum oxide.

[0044] Specifically, the light source assembly 240 includes an LED light source 241 and a cooling member 242. The LED light source 241 is arranged between the cooling member 242 and the reactor 200. The cooling member 242 is provided with a containing cavity for containing a cooling liquid. The cooling liquid cools the LED light source 241. The cooling member 242 is further provided with a cooling liquid inlet 243 and a cooling liquid outlet 244. The cooling liquid enters from the cooling liquid inlet 243, flows through the LED light source 241 and then flows out from the cooling liquid outlet 244. The light source assembly 240 adopts water-cooling type heat dissipation.

[0045] Further, the first reaction assembly comprises a filter screen plate 228, a fixed bed 221, and a reaction channel, the reaction channel and the catalyst 222 are arranged in the fixed bed 221, the reaction channel is provided with a first reaction liquid inlet 223 and a first reaction liquid outlet 224, the first reaction liquid inlet 223 is connected with the feeding device 100, the first reaction liquid outlet 224 is connected with the separation device 400, the filter screen plate 228 is arranged at the first reaction liquid outlet 224, the reaction liquid can enter the reaction channel through the first reaction liquid inlet 223 and react under the catalysis of the catalyst 222, and the reacted reaction liquid flows out through the filter screen plate 228 and the first reaction liquid outlet 224. A first fastening screw is arranged at the first reaction liquid inlet 223, an inlet sealing ring 226 is arranged between the first reaction liquid inlet 223 and the first fastening screw, the first fastening screw is a hollow structure, the hollow part of the first fastening screw is sealed by an inlet sealing screw 227, in order to increase the sealing degree between the inlet sealing screw 227 and the inlet fastening screw 225, an inlet sealing element 2271 and an inlet sealing sleeve 2272 are arranged between the inlet sealing screw 227 and the inlet fastening screw 225. An outlet fastening screw 229 is arranged at the first reaction liquid outlet 224, and an outlet sealing ring 2291 is arranged between the outlet fastening screw 229 and the first reaction liquid outlet 224. Specifically, the heater 210 is in the shape of a cylinder as a whole, the fixed bed 221 is located at the center position of the heater 210, so as to increase the contact area between the heater 210 and the reaction channel, and more effectively transfer the heat of the heater 210 to the reaction channel, so as to effectively control the temperature in the reaction channel.

[0046] Further, the second reaction assembly 230 comprises a reaction tube, the reaction tube is provided with a second reaction liquid inlet 231 and a second reaction liquid outlet 232, the second reaction liquid inlet 231 is connected with the feeding device 100, the connection of the feeding device 100 with the first reaction liquid inlet 223 and the second reaction liquid inlet 231 is switched by a manual switching joint, the second reaction liquid outlet 232 is connected with the separation device 400, the reaction tube is spirally wound on the outer periphery of the heater 210, the cooling element 242 is in the shape of a cylinder as a whole, the LED light source 241 is arranged between the cooling element 242 and the reaction tube, that is, the LED light source 241 is arranged close to the surface of the cooling element 242 facing the reaction tube, the LED light source 241 can irradiate the reaction tube in all directions, and a heat-conducting copper plate 250 is arranged between the LED light source 241 and the cooling element 242. The temperature of the LED light source 241 will rise in a long time of working, the rise of the temperature will affect the operation of the reactor 200, the cooling liquid is injected into the containing cavity of the cooling element 242, and the temperature of the LED light source 241 can be effectively reduced through heat transfer between the cooling liquid and the LED light source 241.

[0047] Specifically, when the reaction is a solid catalyst 222 reaction, the reaction liquid flows into the filter screen plate 228 and reacts under the catalysis of the catalyst 222; when the reaction is a photocatalytic reaction, the reaction liquid flows into the reaction tube and reacts under the irradiation of a light source. The light source can provide light of different wavelengths, and the wavelength of the light can be selected according to the wavelength of different reactions.

[0048] The inner diameter of the filter screen plate 228 and the reaction tube is larger than the inner diameter of the pipeline in the prior art, such as a microfluidic chip. The inner diameter of the pipeline in the prior art is generally 50-100 um, the size of the filter screen plate 228 is 20-50 um, the size of the reaction tube is 800 um-2000 um, and the inner diameter of the fixed bed 221 is 10-30 mm. The flow rate of the pipeline is increased. The heater 210 can heat the filter screen plate 228 and the reaction tube, which can meet the heating requirements of the photocatalytic and solid catalyst 222 catalytic reactions, and realize the reactions that require heating.

[0049] More specifically, the material of the reaction tube includes at least one of a metal material and a resin material, and is preferably FEP material, which has better light transmittance and better chemical compatibility. The inner diameter of the reaction tube is preferably between 0.8-2 mm, which can save raw materials and reduce the cost of process development or verification under the premise of meeting the process verification and development before industrialization.

[0050] Preferably, the filter screen plate 228 is a metal material, preferably a hastelloy, and has different specifications, such as 5 um, 20 um, 50 um, etc.

[0051] More preferably, the material of the fixed bed 221 is a metal material, preferably a hastelloy, and has different inner diameter specifications, preferably between 10-30 mm.

[0052] The continuous flow high-throughput screening system of the embodiment is a multifunctional reactor 200, which not only increases the flow rate of the reaction liquid and facilitates the guidance before industrialization, but also can select the reaction of the solid catalyst 222 or the reaction of the photocatalyst 222 in the continuous flow reactor 200 according to the reaction requirements of the solvent. It solves the problem of heterogeneous chemical reactions with solid participation and can realize the reaction of gas, liquid and solid multiphase system. The separation system is used for the separation of reaction products, and the separation system is connected with the continuous flow reactor 200; the separation system includes a high-performance liquid chromatograph and a column oven, and the high-performance liquid chromatograph and the column oven are respectively electrically connected with the control system.

[0053] In the embodiment, the analysis device 500 is used for the characterization of the reaction solvent, the reaction material and the product, the separation device 400 is a liquid chromatograph, and the liquid chromatograph is provided with a column oven. The column oven is used to keep the reaction liquid at a constant temperature.

[0054] In the present embodiment, the analysis device 500 comprises a DAD detector and a mass spectrometry detector, both of which are electrically connected with the control system.

[0055] In another embodiment, as shown in the figure, a high-throughput screening method for the above screening system comprises the following steps: Figure 6

[0056] S100, set the solvent by the software operation program of the control device, select the valve site of the multi-way valve, select the reaction solvent, and the solvent pump extracts the solvent in the solvent bottle to enable constant flow of the solvent in the pipeline.

[0057] S200, degas the solvent delivered by the multi-way valve by the degassing machine to avoid the influence of bubbles and make the flow rate reach the set accuracy.

[0058] S300, set the reaction sequence by the software system of the control device and trigger the automatic sampler to sample, the sampling needle of the automatic sampler samples in the sample bottle in turn, and each reaction component is sequentially punched into the quantitative ring, the quantitative ring pre-mixes each component reaction reagent, then switches the first six-way valve, uses the solvent to punch the reaction liquid into the reactor for reaction, and the solvent pushes each component reactant into the ultraviolet detector to generate a signal intensity response, while ensuring that all reaction liquids can enter and flow out of the reactor at the same time.

[0059] S400, set the reaction temperature by the software system of the control device, and select whether the reaction liquid enters the first reaction liquid inlet or the second reaction liquid inlet according to the catalytic type of the reaction liquid, and the reaction residence time is determined according to the length of the pipeline on the heating block and the flow rate.

[0060] S500, after the reaction is completed, a part of the reaction liquid (5 μL) is separated and quantitatively analyzed by high performance liquid chromatography (HPLC), and the rest of the reaction liquid flows away as waste liquid, and the excess reaction liquid flows into the waste liquid collector for unified treatment, and then a part of the reaction liquid (1 μL) is separated from the back end of the HPLC and enters the back end mass spectrometer for qualitative analysis.

[0061] S700, based on a large amount of experimental data generated by rapid and efficient reaction, through artificial intelligence process route screening, and process verification and online analysis of the screened process by the automatic device, the rapid screening of the optimal reaction condition is obtained.

[0062] As shown in the figure, the screening method is explained: Figure 7 1. First, select a chemical reaction process and input the target value a of the product demand;

[0063]

[0064] ​​2. Edit the sequence of reaction conditions to be screened, such as temperature, concentration, reaction time, etc., and input and save to the system controller;

[0065] 3. The system controls the automatic sampler and the feed pump to start running, and pumps the reaction reagents into the continuous flow reactor according to the operation sequence, takes the product sample for LC-MS analysis, records the LC-MS value Di (i is the sequence number), and compares it with the target value a. If Di > a, the reaction condition corresponding to the i sequence is the optimal reaction condition;

[0066] 4. If Di ≤ a, the control system continues to determine whether the edited sequence has been run to completion. If not, the sequence continues to be executed. If yes, the reaction condition corresponding to the highest value of Di in the sequence is the suboptimal reaction condition.

[0067] The above only describes the preferred embodiments of the present application, and does not limit the patent scope of the present application. Any equivalent structural transformation, direct / indirect application in other related technical fields, or the like within the inventive concept of the present application, and using the content of the present application specification and drawings, are included in the patent protection scope of the present application.

Claims

1. A high throughput screening system, characterized in that, The application relates to a reaction system for preparing a reaction product, which comprises: a feeding device; a reactor connected with the feeding device, the feeding device being used for providing a pre-designed amount of a reaction solvent and a reaction material and conveying the reaction solvent and the reaction material to the reactor, the reactor being used for reacting the reaction solvent and the reaction material to generate a reaction product and mixing the reaction product into a reaction liquid; a separation device connected with the reactor, the reactor also being used for conveying the reaction liquid to the separation device, the separation device being used for separating components of the reaction liquid; an analysis device connected with the separation device, the separation device also being used for conveying the reaction liquid separated by the separation device to the analysis device, the analysis device being used for qualitatively and quantitatively analyzing the components of the reaction liquid; and a control device electrically connected with the feeding device, the reactor, the separation device and the analysis device, the control device being used for screening optimal reaction conditions according to the analysis result of the analysis device. The reactor comprises: a heater; a first reaction assembly arranged in the heater, a catalyst being further arranged in the first reaction assembly, one end of the first reaction assembly being connected with the feeding device, and the other end of the first reaction assembly being connected with the separation device; a second reaction assembly arranged at the periphery of the heater, one end of the second reaction assembly being connected with the feeding device, and the other end of the second reaction assembly being connected with the separation device; and a light source assembly arranged at the periphery of the second reaction assembly.

2. The screening system of claim 1, wherein, The second reaction assembly comprises a reaction tube spirally wound at the periphery of the heater, and the inner diameter of the reaction tube is 800-2000 um.

3. The screening system of claim 1, wherein, The first reaction assembly comprises a fixed bed and a reaction channel, the reaction channel and the catalyst being arranged in the fixed bed, the reaction channel being provided with a first reaction liquid inlet and a first reaction liquid outlet, the first reaction liquid inlet being connected with the feeding device, and the first reaction liquid outlet being connected with the separation device, the reaction liquid being able to enter the reaction channel through the first reaction liquid inlet and react under the catalysis of the catalyst, and the reacted reaction liquid flowing out through the first reaction liquid outlet.

4. The screening system of claim 1, wherein, The reaction tube is provided with a second reaction liquid inlet and a second reaction liquid outlet, the second reaction liquid inlet being connected with the feeding device, and the second reaction liquid outlet being connected with the separation device. The light source assembly comprises an LED light source and a cooling member, the LED light source being arranged at the inner side of the cooling member and between the cooling member and the reactor, the cooling member being provided with a containing cavity for containing a cooling liquid, the cooling liquid being used for cooling the LED light source, and the cooling member being further provided with a cooling liquid inlet and a cooling liquid outlet.

5. The screening system of claim 1, wherein, The feeding device comprises a multi-way valve, a degasser, a solvent pump, an automatic sampler, a quantitative ring, a first six-way valve and an ultraviolet detector, the multi-way valve, the degasser, the solvent pump, the automatic sampler, the quantitative ring, the first six-way valve and the ultraviolet detector are electrically connected with the control device, the multi-way valve is used for connecting a plurality of solvent bottles, the solvent bottles contain the reaction solvent, one end of the multi-way valve is connected with the degasser, the other end of the degasser is connected with the solvent pump, the first six-way valve is connected with the solvent pump, the quantitative ring and the ultraviolet detector respectively, the automatic sampler is connected with the quantitative ring, and the ultraviolet detector is connected with the reactor.

6. The screening system of claim 1, wherein, The separation device is a liquid chromatography separator, and a column oven is arranged in the liquid chromatography separator, and the column oven is used for keeping the reaction liquid at a constant temperature.

7. The screening system of claim 1, wherein, The analysis device comprises a DAD detector and a mass spectrometry detector, and the DAD detector and the mass spectrometry detector are electrically connected with the control device.

8. The screening system of claim 1, wherein, The material of the heater comprises at least one of copper and aluminum oxide.

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