Skin care composition comprising a combination of vitamin b3 and two peptides

Abstract

The present invention provides a skin care composition comprising a combination of a vitamin B3 compound, palmitoyl pentapeptide-4, acetyl tetrapeptide-11, and a dermatologically acceptable carrier. The combination of the vitamin B3 compound, palmitoyl pentapeptide-4, and acetyl tetrapeptide-11 increases activation of the antioxidant response element (ARE) of cells (e.g., synergistically) to improve visible signs of aging skin.

Description

Technical Field

[0001] This disclosure generally relates to improving skin health through the synergistic combination of skin-care active ingredients. More specifically, this disclosure relates to a combination of vitamin B3 and two or more peptides that synergistically stimulate cellular antioxidant and repair processes. Background Technology

[0002] Skin is the first line of defense against environmental damage, which can harm sensitive underlying tissues and organs, and it plays a crucial role in a person's physical appearance. Signs of aging, such as wrinkles and age spots, are an unwelcome reminder of the passing of youth. Therefore, in today's youth-conscious society, addressing signs of skin aging has become a rapidly growing industry.

[0003] Skin is composed of a variety of different cells that work together in a dynamic and complex relationship to maintain skin health. However, as skin cells age or become damaged, they often lose the functions needed to maintain youthful, healthy skin. Skin cells can be damaged by a variety of endogenous and exogenous stressors, such as ultraviolet radiation, pollution, and smoking. In some cases, these stressors lead to the production of reactive oxygen species (ROS), which disrupt normal cellular processes. As a response, human cells have evolved defenses against ROS, but these defenses can be overwhelmed by stressor-induced spikes in ROS, leading not only to acute but also chronic changes in intracellular homeostasis. As ROS accumulate over time, they cause oxidative stress at the cellular level, which can ultimately manifest as visible signs of aging, such as fine lines, wrinkles, hyperpigmentation, and thinning skin.

[0004] The antioxidant defense system of most cells is typically controlled by a master switch called antioxidant response elements (AREs). AREs are cis-acting enhancer sequences located in the regulatory regions of antioxidant and detoxification genes. AREs are activated via redox cycles of phenols and electrophiles. Some studies have shown that a protein called nuclear factor erythroid 2-associated factor 2 (Nrf2) may be a key transcription factor essential for ARE activation, even though many other transcription factors also bind to ARE sequences. When AREs are activated in response to ROS-induced damage, the corresponding genes signal the cell to begin producing redox / oxidation regulators and / or ROS-quenching proteins and enzymes. In addition to regulating the production of redox regulators and ROS-quenching compounds, AREs can also signal the cell to initiate repair processes. Therefore, promoting ARE activation in aging skin cells is desirable to combat signs of skin aging caused by oxidative stress.

[0005] Many compounds that promote ARE activation have been discovered. For example, US20160317419 provides data showing that the combination of nicotinamide and nicotinamide nucleoside promotes ARE activation. However, there is still a need to identify compounds and methods that improve cellular antioxidant capacity by promoting ARE activation. There is also a need to identify compounds and methods that beneficially regulate genes involved in cellular antioxidant and repair processes. Summary of the Invention

[0006] This disclosure relates to a skincare composition comprising a combination of a vitamin B3 compound, palmitoyl pentapeptide-4 (pal-KTTKS) [SEQ ID NO:1], acetyl tetrapeptide-11 (ac-PPYL) [SEQ ID NO:2], and a dermatologically acceptable carrier. The combination of the vitamin B3 compound, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2] has been found to activate cellular antioxidant response elements (AREs) and / or beneficially regulate genes involved in cellular antioxidant and repair processes, in some cases synergistically. This disclosure also relates to methods of using the above composition. Detailed Implementation

[0007] Improving cellular antioxidant and repair processes is crucial for enhancing skin health and / or appearance. Therefore, there has long been a need to identify novel ingredients for use in topical skincare compositions that deliver these beneficial effects. Specifically, there is a need to identify compounds that promote ARE activation in skin cells, which are more susceptible to oxidative stress than some other cell types due to their high exposure to UV radiation and other exogenous stressors. It has now been surprisingly found that the combination of vitamin B3 compounds, palmitoyl pentapeptide-4 [SEQ ID No:1], and acetyl tetrapeptide-11 [SEQ ID NO:2] stimulates both antioxidant and cellular repair processes. Specifically, this combination of ingredients has been found to synergistically promote ARE activation and / or regulate certain genes believed to be involved in cellular antioxidant and repair processes.

[0008] References to "implementation" or similar methods herein refer to specific materials, features, structures, and / or characteristics described in connection with that implementation being included in at least one implementation, or optionally multiple implementations, but do not imply that all implementations include the described materials, features, structures, and / or characteristics. Furthermore, materials, features, structures, and / or characteristics may be combined in any suitable manner in different implementations, and materials, features, structures, and / or characteristics may be omitted or replaced in their description. Therefore, unless otherwise stated or declared as incompatible, although not expressly illustrated in the combination, the implementations and aspects described herein may include elements or components of other implementations and / or aspects, or may be combined with elements or components of other implementations and / or aspects.

[0009] In all embodiments, unless otherwise specified, all ingredient percentages are based on the weight of the cosmetic composition. Unless otherwise specified, all ratios are by weight. Significant figures do not express any limitation on the quantities shown or on the accuracy of the measurement. All values ​​should be understood to be modified by the word “about” unless otherwise specified. Unless otherwise specified, all measurements are understood to have been performed at approximately 25°C and ambient conditions, where “ambient conditions” means conditions at approximately 1 atmosphere and approximately 50% relative humidity. All numerical ranges are inclusive and can be combined to form narrower ranges not explicitly disclosed. For example, the upper and lower limits of the depicted ranges are interchangeable to form additional ranges.

[0010] The compositions of the present invention may comprise, consist of, or be composed of the basic components described herein, as well as optional ingredients. As used herein, “consistently consisting of” means that a composition or component may contain only additional ingredients that do not substantially alter the essential and novel features of the composition or method protected by the claims. As used in the specification and appended claims, unless the context clearly indicates otherwise, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well.

[0011] sequence list

[0012] A sequence listing of the amino acid sequences of SEQ ID NO:1 and SEQ ID NO:2, and the nucleotide sequences of SEQ ID NO:3 to SEQ ID NO:7 (which are primary sequences and include variants with conserved modifications) is submitted with this application as an ASCII text file entitled “15964_seq_list_ST25”. This ASCII text file was created on January 19, 2021, and is 201 KB in size. Subject matter of this ASCII text file is incorporated herein by reference in accordance with MPEP §605.08 and 37 CFR §1.52(e).

[0013] definition

[0014] The word “about” modifies a specific value by referring to a range equal to or less than 20 percent (+ / - 20%) of the specified value (e.g., less than 15%, 10%, or even less than 5%).

[0015] As used in this article with respect to a composition or material, “apply” means placing or applying the composition onto a surface of human skin, such as the epidermis.

[0016] "Cosmetic composition" means a composition that contains cosmetic agents and is intended for non-therapeutic (i.e., non-medical) use. Examples of cosmetic compositions include tinted cosmetics (such as foundation, lipstick, concealer, and mascara), skin care compositions (such as moisturizers and sunscreens), personal care compositions (such as rinse-off and leave-on bath products and soaps), and hair care compositions (such as shampoos and conditioners).

[0017] "Derivative" refers to an amide, ether, ester, amino, carboxyl, acetyl, or alcohol derivative of a given compound.

[0018] "Effective amount" means an amount of compound or composition sufficient to significantly induce a positive beneficial effect on keratinocytes during the treatment period. Positive beneficial effects can be health, appearance, and / or sensory benefits, including individual or combined beneficial effects disclosed herein.

[0019] "Regulation" and its variants refer to upregulating or downregulating gene expression.

[0020] "Skincare" refers to conditioning and / or improving skin condition (e.g., skin health, appearance, or texture / feel). Some non-limiting examples of improving skin condition include improving skin appearance and / or feel by providing a smoother, more even appearance and / or feel; increasing the thickness of one or more layers of skin; improving skin elasticity or resilience; improving skin firmness; and reducing the oily, shiny, and / or dull appearance of skin; improving skin hydration or moisturization; improving the appearance of fine lines and / or wrinkles; improving skin peeling or flaking; plumping the skin; improving skin barrier properties; improving skin tone; reducing the appearance of redness or rashes; and / or improving skin radiance, luminosity, or translucency.

[0021] "Skincare active ingredients" refer to compounds or combinations of compounds that, when applied to the skin, provide immediate and / or long-lasting beneficial effects to the skin or the cell types typically present therein. Skincare active ingredients can modulate and / or improve the skin or its related cells (e.g., improve skin elasticity, hydration, skin barrier function, and / or improve cell metabolism).

[0022] "Skincare composition" means a composition that contains skincare active ingredients and regulates and / or improves skin condition.

[0023] "Skin cells" refers to cell types commonly found in human skin. Non-limiting examples of skin cells include keratinocytes, fibroblasts, melanocytes, Langerhans cells, and Merkel cells.

[0024] "Synergistic effect" and its variations refer to the cellular antioxidant and repair effects provided by the combination of nicotinamide, palmitoyl pentapeptide-4 [SEQ ID NO:1], and acetyl tetrapeptide-11 [SEQ ID NO:2] being greater than the expected additive effect of these components individually. For example, a synergistic effect is demonstrated when the combination of nicotinamide, palmitoyl pentapeptide-4 [SEQ ID NO:1], and acetyl tetrapeptide-11 [SEQ ID NO:2] increases ARE activation by a greater margin than the calculated additive effect of each of the three components individually. ARE activation levels can be quantified using the ARE assay described in more detail below.

[0025] As used herein, “treatment period” refers to the length of time and / or frequency of application of a material or composition to the target skin surface.

[0026] "Upregulation" and its variations refer to an increase in gene expression. Conversely, "downregulation" and its variations refer to a decrease in gene expression. Gene expression can be quantified using conventional methods such as microarray analysis, rt-PCR, and proteoblotting.

[0027] Skin care composition

[0028] The novel skincare compositions described herein are intended for topical application to human skin to provide beneficial cellular antioxidant and / or repair effects. The skincare compositions of this invention contain safe and effective amounts of a vitamin B3 compound, palmitoyl pentapeptide-4 (pal-KTTKS) [SEQ ID NO:1], and acetyl tetrapeptide-11 (ac-PPYL) [SEQ ID NO:2]. The combination of these three ingredients in effective amounts synergistically promotes the activation of antioxidant response elements, which is important for combating oxidative stress and reducing visible signs of skin aging.

[0029] The combination of vitamin B3 compounds, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2] can also synergistically regulate one or more genes selected from nuclear factor erythroid 2-associated factor 2 (NFE2L2) [SEQ ID NO:3] (primary sequence) and its conserved modified variants, Schlafen family member 5 (SLFN5) [SEQ ID NO:4] (primary sequence) and its conserved modified variants, glycerol phosphate diester phosphodiesterase 1 (GDE1) [SEQ ID NO:5] (primary sequence) and its conserved modified variants, inositol polyphosphate phosphokinase 1 (MINPP1) [SEQ ID NO:6] (primary sequence) and its conserved modified variants, and 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL) [SEQ ID NO:7] (primary sequence) and its conserved modified variants. Unconstrained by theory, these genes are thought to play important roles in cellular antioxidant and / or repair processes, and have been shown to be downregulated due to chronological aging and / or photoaging in the epidermis and / or dermis. For example, NRF2 is thought to play a crucial role in activating ARE (Annu RevPharmacol Toxicol. 2013; 53:401–426). In another example, SLFN5 is thought to play a role in controlling extracellular matrix (ECM) remodeling enzymes. Oxidative stress conditions stimulate ECM degradation by upregulating metalloproteinases (MMPs). Upregulation of SLFN5 reduces the expression of these MMPs, thus enhancing ECM integrity.

[0030] Regarding the promotion of ARE activation and / or regulation of the expression of one or more of the above-mentioned genes, the combination of vitamin B3 compound, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2] may exhibit a synergistic effect of a factor of 1.2 or higher (e.g., greater than 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or even 2.0) relative to the sum of responses to treatment with nicotinamide, pal-KTTKS, and ac-PPYL alone, such as a vector control or a predetermined threshold. In some cases, the composition may contain a weight ratio of vitamin B3 compound to pal-KTTKS [SEQ ID NO:1] to ac-PPYL [SEQ ID NO:2] between 500:1:2 and 1:1:0.5 (e.g., between 50:1:2 and 1:1:1). Methods for determining synergistic factors are described in more detail below.

[0031] The skincare compositions described herein may be cosmetic compositions, pharmaceutical compositions, or medicated cosmetic compositions, and may be provided in various product forms, including but not limited to solutions, suspensions, lotions, creams, gels, toners, sticks, sprays, aerosols, ointments, cleansing liquids and solid sticks, pastes, foams, mousses, shaving creams, wipes, strips, patches, motorized patches, hydrogels, film-forming products, facial and skin masks (with and without insoluble sheets), cosmetics such as foundation, eyeliner, and eyeshadow. In some cases, the composition form may conform to a selected, dermatologically acceptable carrier. For example, the composition (and carrier) may be provided as an emulsion (e.g., water-in-oil, oil-in-water, or oil-in-water) or an aqueous dispersion.

[0032] The compositions described herein can be prepared using conventional methods for preparing topical skincare compositions. Such methods typically involve mixing the ingredients to a relatively homogeneous state in one or more steps, with or without heating, cooling, applying vacuum, etc. Preferably, the compositions are prepared to optimize stability (physical stability, chemical stability, photostability) and / or delivery of the active substance. Such optimization may include an appropriate pH (e.g., less than 7), excluding substances that can complex with the active agent and thus negatively affect stability or delivery (e.g., excluding contaminating iron), using methods to prevent complex formation (e.g., appropriate dispersants or double-compartment packaging), using appropriate photostability methods (e.g., combining with sunscreens, using opaque packaging), etc.

[0033] Vitamin B3 compounds

[0034] The compositions described herein contain a safe and effective amount of a vitamin B3 compound. In some cases, the compositions of the present invention may contain 0.01% to 10% (e.g., 0.1% to 10%, 0.5% to 5%, or even 1% to 3%) of a vitamin B3 compound based on the weight or volume of the composition.

[0035] As used in this article, "vitamin B3 compound" refers to a compound having the following formula:

[0036]

[0037] Wherein: R is CONH2 (i.e., nicotinamide), COOH (i.e., nicotinic acid), or CH2OH (i.e., nicotinic alcohol); their derivatives; and a salt of any of the aforementioned substances.

[0038] Exemplary derivatives of vitamin B3 compounds include nicotinic acid esters, which include non-vasodilatory nicotinic acid esters (e.g., nicotinic acid tocopheryl ester, nicotinic acid tetradecyl ester), nicotinamide nucleoside, nicotinic amino acid, nicotinic acid esters of carboxylic acids, nicotinic acid N-oxide, and nicotinamide N-oxide.

[0039] Pentapeptide

[0040] The compositions described herein contain a safe and effective amount of palmitoyl pentapeptide, pal-KTTKS [SEQ ID NO:1] (INCI: palmitoyl pentapeptide-4). In some cases, pal-KTTKS may be present in the compositions of the present invention at 0.0001% to 3% (e.g., 0.001% to 2%, 0.01% to 1%, or 0.1% to 0.5%). Pal-KTTKS is obtained under the trade name PROMATRIXYL from Sederma (France).

[0041] Tetrapeptide

[0042] The compositions described herein contain a safe and effective amount of acetylated tetrapeptide ac-PPYL [SEQ ID NO:2] (INCI: Acetyl Tetrapeptide-11). In some cases, ac-PPYL may be present in the compositions of the present invention at 0.0001% to 3% (e.g., 0.001% to 2%, 0.01% to 1%, or 0.1% to 0.5%). Ac-PPYL is available under the trade name SYNIORAGE from BASFCare Creations (New Jersey).

[0043] Dermatologically acceptable carriers

[0044] The compositions described herein include dermatologically acceptable carriers (which may be referred to as "carriers"). The phrase "dermatologically acceptable carrier" means that the carrier is suitable for topical application to keratinocytes, has good aesthetic properties, is compatible with the active substances in the composition, and does not cause any unreasonable safety or toxicity issues. In one embodiment, the carrier is present in an amount of about 50% to about 99%, about 60% to about 98%, about 70% to about 98%, or about 80% to about 95% by weight of the composition.

[0045] The carrier can take many forms. In some cases, the solubility or dispersibility of the components (e.g., extracts, sunscreen active ingredients, additives) determines the form and characteristics of the carrier. Non-limiting examples include simple solutions (e.g., aqueous or anhydrous), dispersions, emulsions, and solid forms (e.g., gels, sticks, flowable solids, or amorphous materials). In some cases, dermatologically acceptable carriers are in the form of emulsions having a continuous aqueous phase (e.g., oil-in-water or water-in-oil-in-water emulsions) or a continuous oil phase (e.g., water-in-oil or water-in-oil-in-oil emulsions). The oil phase of the emulsion may contain silicone oils, non-silicone oils (such as hydrocarbon oils, esters, ethers), and mixtures thereof. The aqueous phase may contain water and water-soluble ingredients (e.g., water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other skin-care active ingredients). In some cases, the aqueous phase may contain components that are not water, including but not limited to water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other water-soluble skin-care active ingredients. In some cases, the non-aqueous components of the composition include wetting agents, such as glycerin and / or other polyols.

[0046] In some cases, the compositions herein are in the form of an oil-in-water (“O / W”) emulsion that provides a mild and non-greasy sensory experience. Suitable O / W emulsions herein may comprise a continuous aqueous phase of greater than 50% by weight of the composition, with the remainder being a dispersed oil phase. The aqueous phase may comprise 1% to 99% water by weight, along with any water-soluble and / or water-miscible components. In these cases, the dispersed oil phase will typically be present at less than 30% by weight of the composition (e.g., 1% to 20%, 2% to 15%, 3% to 12%, 4% to 10%, or even 5% to 8%) to help avoid some undesirable sensory effects of oily compositions. The oil phase may comprise one or more volatile and / or non-volatile oils (e.g., vegetable oils, silicone oils, and / or hydrocarbon oils). Some non-limiting examples of oils suitable for use in the compositions of the present invention are disclosed in U.S. Patent 9,446,265 and U.S. Publication 2015 / 0196464.

[0047] The carrier may contain one or more dermatologically acceptable diluents. As used herein, “diluent” means a material in which the skincare active ingredient described herein can be dispersed, dissolved, or otherwise incorporated. Some non-limiting examples of hydrophilic diluents include water, organic hydrophilic diluents such as lower monovalent alcohols (e.g., C1-C4) and low molecular weight diols and polyols, including propylene glycol, polyethylene glycol (e.g., molecular weight 200 g / mol to 600 g / mol), polypropylene glycol (e.g., molecular weight 425 g / mol to 2025 g / mol), glycerin, butylene glycol, 1,2,4-butanetriol, sorbitan ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitan ester, butylene glycol, ether propanol, ethoxylated ether, propoxylated ether, and combinations thereof.

[0048] Conditioner

[0049] The compositions described herein may contain 0.1% to 50% by weight of a conditioning agent (e.g., 0.5% to 30% by weight, 1% to 20% by weight, or even 2% to 15% by weight). Adding a conditioning agent can help provide the composition with desired sensory properties (e.g., a silky, lubricating feel upon application). Some non-limiting examples of conditioning agents include hydrocarbon oils and waxes, siloxanes, fatty acid derivatives, cholesterol, cholesterol derivatives, diglycerides, triglycerides, vegetable oils, vegetable oil derivatives, acetylglucosides, alkyl esters, alkenyl esters, lanolin, wax esters, beeswax derivatives, sterols and phospholipids, their salts, isomers and derivatives, and combinations thereof. Particularly suitable examples of conditioning agents include volatile or non-volatile silicone fluids such as polydimethylsiloxane copolyols, dimethylpolysiloxanes, diethylpolysiloxanes, mixed C1-30 alkylpolysiloxanes, phenyl polydimethylsiloxanes, polydimethylsiloxane alcohols, polydimethylsiloxanes, polydimethylsiloxanes, polydimethylsiloxane crosspolymers, and combinations thereof. Polydimethylsiloxanes may be particularly suitable because some consumers associate the sensory properties provided by certain polydimethylsiloxane fluids with good moisturizing properties. Other examples of silicone fluids suitable for use as conditioning agents are described in U.S. Patent No. 5,011,681.

[0050] rheology modifiers

[0051] The compositions described herein may contain 0.1% to 5% of a rheology modifier (e.g., a thickener) to provide suitable rheological and skin-feel properties to the composition. Some non-limiting examples of thickeners include cross-linked polyacrylate polymers, polyacrylamide polymers, polysaccharides, gums, and mixtures thereof. In a particularly suitable example, the composition may contain a superabsorbent polymer thickener, such as sodium polyacrylate, starch-grafted sodium polyacrylate, or combinations thereof. Some non-limiting examples of superabsorbent polymer thickeners are described, for example, in U.S. Patent 9,795,552.

[0052] Some consumers have found that compositions using siloxane fluids as conditioners have an undesirable greasy or heavy feel. Therefore, it may be desirable to provide compositions that are free of or substantially free of siloxane fluids. It may also be desirable to customize superabsorbent polymer thickeners to provide a light, breathable feel to the composition, for example, by adjusting the amount of water in the composition, the water:oil ratio (e.g., 12:1 to 1:1), and / or the ratio of water to thickener or oil to thickener.

[0053] emulsifier

[0054] When a dermatologically acceptable carrier is in emulsion form, it may be desirable to include an emulsifier to provide a stable composition (e.g., no phase separation). When an emulsifier is included, it may be present in amounts from 0.1% to 10% (e.g., 1% to 5%, or 2% to 4%). The emulsifier may be nonionic, anionic, or cationic. Some non-limiting examples of emulsifiers suitable for use herein are disclosed in U.S. Patent Nos. 3,755,560; 4,421,769 and McCutcheon's "Detergents and Emulsifiers," North American Edition, pp. 317-324 (1986).

[0055] Other optional ingredients

[0056] The compositions of the present invention may optionally contain one or more additives commonly used in cosmetic compositions (e.g., colorants, skin-care active substances, anti-inflammatory agents, sunscreens, emulsifiers, buffers, rheology modifiers, combinations thereof, etc.), provided that the additive does not adversely alter the beneficial effects on skin health or appearance provided by the compositions of the present invention. When incorporated into a composition, the additive should be suitable for contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, etc. Some non-limiting examples of added active substances include vitamins, minerals, peptides and peptide derivatives, glycosamines, sunscreens, oil-controlling agents, particles, flavonoids, hair growth regulators, antioxidants and / or antioxidant precursors, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliating agents, skin brighteners, sun-free tanning agents, lubricants, anti-acne active substances, anti-cellulite active substances, chelating agents, anti-wrinkle active substances, anti-atrophy active substances, phytosterols and / or plant hormones, N-acyl amino acid compounds, antimicrobial agents, and antifungal agents. Other non-limiting examples of adjunct ingredients and / or skincare active substances applicable herein are described in U.S. Patent Publications 2002 / 0022040, 2003 / 0049212, 2004 / 0175347, 2006 / 0275237, 2007 / 0196344, 2008 / 0181956, 2008 / 0206373, 2010 / 00092408, 2008 / 0206373, 2010 / 0239510, and 2010 / 0189669. US Patent Nos. 2010 / 0272667, 2011 / 0262025, 2011 / 0097286, 2012 / 0197016, 2012 / 0128683, 2012 / 0148515, 2012 / 0156146 and 2013 / 0022557, and US Patent Nos. 5,939,082, 5,872,112, 6,492,326, 6,696,049, 6,524,598, 5,972,359 and 6,174,533.

[0057] When optional ingredients are included in the compositions herein, it may be desirable to select ingredients that do not form complexes or otherwise undesirably interact with other ingredients in the composition, particularly pH-sensitive ingredients such as nicotinamide, salicylates, and peptides. When present, the optional ingredients may be included in amounts from 0.0001% to 50%; 0.001% to 20%; or even 0.01% to 10% (e.g., 50%, 40%, 30%, 20%, 10%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.1%) based on the weight of the composition.

[0058] How to use

[0059] The method of the present invention includes identifying a target skin portion to be treated and applying a composition comprising an effective amount of a vitamin B3 compound, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2], and optionally one or more additional skin-care active ingredients to the target skin portion. The target skin portion may be on the surface of facial skin (such as the forehead, perioral area, chin, periorbital area, nose, and / or cheeks) or another part of the body (e.g., hands, arms, legs, back, chest). The person or target skin portion to be treated may be a person or target skin portion exhibiting signs of skin aging (e.g., fine lines, wrinkles, hyperpigmentation). In some cases, the target skin portion may not exhibit signs of skin aging, but if the skin portion is typically exposed to high levels of exogenous stressors (e.g., sun-exposed skin such as facial and arm skin), the user may still wish to treat that skin portion. In this way, the method and composition of the present invention can be used preventively to help delay skin aging.

[0060] The composition may be applied to the target skin area and, if necessary, to the surrounding skin at least once daily, twice daily, or more frequently daily during the treatment period. When applied twice daily, the first application should be at least 1 to 12 hours apart from the second application. Typically, the composition may be applied in the morning and / or at bedtime. The treatment period described herein is ideally the time sufficient to improve skin appearance for vitamin B3 compounds, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2]. The treatment period may last at least 1 week (e.g., about 2, 4, 8, or even 12 weeks). In some cases, the treatment period may be extended to several months (i.e., 3 to 12 months). In some cases, the composition may be applied for most of the week (e.g., at least 4, 5, or 6 days per week), at least once daily or even twice daily during a treatment period of at least 2, 4, 8, or 12 weeks.

[0061] The application of the composition can be achieved through topical application. Regarding the application of the composition, the terms "topical," "local," and "partially" mean delivering the composition to a target area (e.g., a hyperpigmented spot or portion thereof) while minimizing delivery to skin surfaces to which treatment is not desired. The composition may be applied to and gently massaged into the skin area. The form of the composition or a dermatologically acceptable carrier should be chosen to facilitate topical application. While some embodiments herein envision topical application of the composition to a specific area, it should be understood that the compositions herein can be applied more comprehensively or extensively to one or more skin surfaces. In some embodiments, the compositions herein can be used as part of a multi-step cosmetic regimen, wherein the compositions of the present invention may be applied before and / or after one or more other compositions.

[0062] ARE measurement

[0063] This method provides a way to quantify ARE activation using the ARE-32 reporter cell line from CXR Biosciences. The ARE-32 cell line is a stable MCF7 cell line containing pGL8x-ARE (eight copies of rat GSTARE linked to the luciferase gene) and pCDNA3.1 (containing a neomycin-selective marker). A detailed description of the ARE-32 cell line and its development and use can be found in “Generation of a Stable Antioxidant Response Element–DrivenReporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents.”, Cancer Res 2006;66(22):10983-94. U.S. Publication No. 2011 / 0262570 describes a general schematic diagram of how the ARE reporter gene assay is performed to identify agents that promote ARE transcription.

[0064] Method Overview :

[0065] ARE assays used expanded and cryopreserved culture stock solutions. Cells were expanded in culture flasks for 4 to 5 days, passaged every 3 to 4 days, at which point the cells reached approximately 80% confluence. When cells were >70% confluence or ready to be seeded into 96-well plates, they were trypsinized, seeded, and grown in 96-well plates. After 1 day of growth in the 96-well plates, the medium was replaced with fresh treatment medium (phenol red-free, FBS-free), and the cells were treated with the compound and incubated overnight (24 hours). After treatment, the cells were washed with 1X PBS, lysed, and subjected to a luciferase kit reagent for luminescence measurement.

[0066] equipment :

[0067] Biosafety cabinet

[0068] Multichannel pipette

[0069] Inverted microscope

[0070] Water bath

[0071] Benchtop centrifuge

[0072] Incubator

[0073] • Board reader (can read illuminated content)

[0074] • Corning 3275 cell culture flask (or comparable product)

[0075] • Pipettes and pipette controllers (excluding Pipet Boy and Drummond Pipet)

[0076] • A suction device that uses pipette tips and hooks to create a vacuum.

[0077] • 96-well plate (Costar, catalog number 3903 or 3610)

[0078] Reagents and materials :

[0079] • Dulbecco modified Eagle medium (DMEM) (Gibco, catalog number 11054-020)

[0080] • Single-injection, heat-inactivated fetal bovine serum (Gibco, catalog number A31604)

[0081] • Genomycin sulfate G418 (G418) (Gibco, catalog number 10131-027)

[0082] • Penicillin-Streptomycin 100X (Gibco, catalog number 15140-148)

[0083] • GlutaMAX supplement 100X (Gibco 35050-061)

[0084] • 0.25% trypsin EDTA (Gibco 25200-056)

[0085] • 0.4% trypan blue, if using a hemocytometer to count cells

[0086] 1X PBS

[0087] • Luciferase assay system including lysis buffer (Promega, catalog number E4530)

[0088] Plate-laying culture medium :

[0089] · 500ml DMEM (Gibco, catalog number 11054-020)

[0090] 0.8 mg / ml G418

[0091] 5ml GlutaMAX

[0092] ·50ml FBS

[0093] ·5ml Pen / Strep

[0094] Treatment culture medium :

[0095] · 500ml DMEM (Gibco, catalog number 11054-020)

[0096] 5ml GlutaMAX

[0097] ·5ml Pen / Strep

[0098] New starting culture :

[0099] Thaw frozen AREC32 cells (frozen in 90% FBS and 10% DMSO) rapidly and place them in a 50ml conical tube containing 25ml of plating medium. Centrifuge at 1500-2000 RPM for 5 minutes. Remove the medium without disturbing the cell pellet. Resuspend the cells in 12ml of medium and add to a T-75 tissue culture flask. Cells should reach >80% confluence within 4-5 days. If more cells are needed, aliquot into T-150 flasks at a 1:3 ratio to allow for cell growth before plating.

[0100] Cell maintenance and passage culture :

[0101] Maintain and plate the cells in 96-well plates with plating medium. Passage the cells every 3 to 4 days or when they reach approximately 75% to 80% confluence (passage). To passage the cells, aspirate the medium from the flask and add 6 ml of 0.25% trypsin. Tilt the flask in all directions to distribute the trypsin across the bottom and place it in an incubator. After 2 to 3 minutes, observe the cells under a microscope to see if they have separated. If the cells have not completely separated, incubate for another 2 to 3 minutes. Once separated, add 6 ml of maintenance medium to neutralize the trypsin and pipette into a centrifuge tube. Centrifuge at 1200 RPM for 5 minutes. Remove the medium without disturbing the cell pellet. Resuspend the pellet in 12 ml of maintenance medium and add it to the flask. If lysing or separating cells from a T-150 flask, double all volumes and follow the same procedure.

[0102] Laminated cells :

[0103] Aspirate the culture medium from the flask and add an appropriate volume of 0.25% trypsin, depending on the flask size (6 ml for T-75, 12 ml for T-150). Vortex the flask to distribute the trypsin at the bottom and return it to the incubator for 2-3 minutes. Observe the cells under a microscope. If the cells are not completely separated, incubate for another 2-3 minutes. Once the cells are separated, add an equal volume of DMEM to the trypsin, mix gently, and transfer to a centrifuge tube. Centrifuge at 12000 RPM for 5 minutes. Aspirate the culture medium without disturbing the cell pellet. Resuspend the pellet in 10 ml of DMEM. Dilute the cells 1:5 with 50 μl of cells + 200 μl of DMEM. Use 20 μl of this dilution and 20 μl of 0.4% trypsin blue. Mix and add 10 μl / chamber to a disposable hemocytometer and insert it into a Countess II instrument. Non-viable cells will be blue, and viable cells will be unstained. Cell seeding density can vary between approximately 10,000 cells / well or more, depending on cell passage growth. On the day of treatment / administration, the cell density should be approximately 70% to 80%. On day 2, replace the plating medium with treatment medium, but do not add penicillin / streptomycin. The medium must be phenol red free.

[0104] Positive control :

[0105] tert-Butylhydroquinone (tBHQ) (Aldrich, catalog number 11294-1). Prepare a 100 mM stock solution (1 M = 166.21 mg / ml; 100 mM = 16.62 mg / ml). Dilute to 750 μM (1:133) with 30 μl of 100 mM tBHQ and 3.62 ml of treatment medium. A 2 μl positive control should produce a final concentration of 7.5 μM in the test wells.

[0106] Test materials :

[0107] The test material can be prepared in DMSO or water, with the final concentration of DMSO not exceeding 1%.

[0108] program :

[0109] Cell preparation and processing:

[0110] 1. In a 96-well plate, place 1.5 × 10 4 One cell per well was seeded in 100 μl of plating medium.

[0111] 2. After keeping the cells at room temperature for 15 minutes, place them in an incubator.

[0112] 3. Incubate the cells at 37°C, 5% CO2 and 95% humidity for 24 hours.

[0113] 4. Replace the culture medium with 99 μl of treatment medium and treat with test compound (2 μl / well), vector control (2 μl / well) and positive control tBHQ (2 μl / well).

[0114] 5. After treatment, 99 μl of culture medium was added, and the final measured volume was 200 μl: adding half the culture medium after administration ensured better distribution of the material.

[0115] 6. Incubate the cells at 37°C, 5% CO2 and 95% humidity for another 24 hours.

[0116] 7. Remove the culture medium and wash the cells once with 100 μl of 1X PBS buffer. Remove the PBS and follow the instructions for the luciferase assay.

[0117] Luciferase assay :

[0118] 1. Prepare 1X lysis reagent by adding 4 volumes of water to 1 volume of 5X lysis reagent.

[0119] 2. Add 20 μl of lysis buffer to each well. Gently shake the plate to dispense the buffer into the wells. Place the plate in an 80°C freezer for 15 minutes to promote dissolution. Thaw the plate completely and confirm dissolution under a microscope.

[0120] 3. Prepare the luciferase assay reagent by adding the luciferase assay buffer to the vial of lyophilized luciferase assay substrate, following the manufacturer's instructions. Mix gently. Add 100 μl of luciferase assay reagent to each well. Ensure there are no air bubbles.

[0121] 4. Immediately use a board reader (e.g., Synergy from BioTek). TM Neo2 brand micro-board reader) reads the board.

[0122] Data computation :

[0123] ARE activation value = luminescence of test sample / (average luminescence of carrier control)

[0124] Vector control = average number of cells + DMSO or water (n=8)

[0125] Gene regulation assay

[0126] This method provides a way to measure the ability of a compound or material to regulate the expression of a target gene.

[0127] cell tertiary keratinocytes (tKC)

[0128] BJ fibroblasts

[0129] planking Cells were plated the day before processing.

[0130] For tertiary keratinocytes: For 12-well plates (e.g., type I collagen-coated plates, Corning catalog number 356500), 100,000 cells / well in 2 ml of culture medium / well; or for 24-well plates, 50,000 cells / well in 1 ml of culture medium / well.

[0131] For BJ fibroblasts: For 12-well plates (e.g., Corning catalog number 3512), 88,000 cells / well in 2 ml of medium / well; or for 24-well plates, 44,000 cells / well in 1 ml of medium / well.

[0132] culture medium For tertiary keratinocytes: EpiLife (e.g., Thermo Fisher Scientific catalog number MEPI500CA+HKGS (e.g., Thermo Fisher Scientific catalog number S-001-5).

[0133] For BJ fibroblasts: EMEM (e.g., ATCC catalog number 30-2003) + 10% FBS (e.g., HyClone catalog number SH30071.02).

[0134] Wafergen method: Total RNA purification and qPCR

[0135] Cell lysates were thawed at 4°C and then isolated using the Biomek FxP and RNAdvance Tissue Isolation Kit (Beckman Coulter, part number A32646). RNA was quantified using a Nanodrop 8000 (Nanodrop, ND-8000). cDNA was generated using 500 ng of total RNA and the Applied Biosystems High Capacity cDNA and Reverse Transcription Assay Kit (Applied Biosystems, part number 4368814). cDNA, assay samples, and dilution buffer from the PrimeTime GeneExpression MasterMix (IDT, part number 1055771) were plated onto a Wafergen MyDesign SmartChip (TakaraBio, part number 640036) using a Wafergen Nanodispenser. Slides were then loaded into a SmartChip circulator and qPCR was performed under the following PCR conditions:

[0136] Holding phase: 50°C for 2 minutes (heating), then 95°C for 10 minutes;

[0137] PCR phase (40 cycles): 95°C for 15 seconds, then 60°C for 1 minute.

[0138] Export the data in .txt file format for analysis.

[0139] Example

[0140] Example 1: Formulation .

[0141] Table 1 below provides examples of the skincare compositions of the present invention. An exemplary composition was prepared by blending phase A components with a suitable mixer (e.g., a Tekmar RW20DZM or equivalent) and heating to a temperature of 70°C to 80°C, while maintaining the temperature through stirring. Phase B components were separately blended with a suitable mixer and heated to 70-75°C, while maintaining the temperature during blending. Phase B was added to phase A while thoroughly mixing to form an oil-in-water (O / W) emulsion. The emulsion was then milled for 5 minutes using a suitable grinder (e.g., a Tekmar T-25 or equivalent). When the emulsion reached 60°C, phase C was added while continuing to mix. When the emulsion reached 40°C, the components of phases D and E were added to the emulsion. The emulsion was then milled for 5 minutes to provide a homogeneous composition.

[0142] Table 1

[0143]

[0144]

[0145]

[0146] Example 2: Vitamin B3 compound, Pal-KTTKS [SEQ] ID NO:1] and Ac-PPYL [SEQ ID NO:2] Simultaneous regulation of NRF2 [SEQ ID NO:4] .

[0147] This example demonstrates the ability of the combination of nicotinamide, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2] to synergistically activate ARE. The test composition and control composition were prepared and tested accordingly in the ARE assay as described above. The vitamin B3 compound used in this example was nicotinamide [Sigma catalog number N5535], pal-KTTKS was PROMATRIXYL from Sederma (France), and ac-PPYL was SYNIORAGE from BASF Care Creations (New Jersey). The results of this test are summarized in Table 2 below. N+P+A refers to the combination of nicotinamide (N), pal-KTTKS (P) [SEQ ID NO:1], and ac-PPYL (A) [SEQ ID NO:2].

[0148] The synergy factor is calculated as follows:

[0149]

[0150] Synergy factors with p-values ​​≤ 0.05 and greater than 1.00 indicate statistically significant synergistic effects. A preferred synergy factor is greater than 1.3.

[0151] Table 2 - Synergistic ARE Activation

[0152]

[0153]

[0154] As can be seen in Table 2, the data indicate that nicotinamide synergistically activates ARE at ratios (N:P:A) between 500:1:2 and 1:1:0.5 with pal-KTTKS [SEQ ID NO:1] and ac-PPYL [SEQ ID NO:2]. However, N:P:A ratios of 500:1:0.05, 50:1:2, 10:1:0.05, 1:1:2, and 1:1:0.05 do not appear to provide a synergistic factor greater than 1.3. Therefore, it is important to select the correct combination of vitamin B3 compounds, pal-KTTKS [SEQ ID NO:1], and ac-PPYL, as shown in Table 2, to provide the desired synergistic effect.

[0155] Example 3: Tetrapeptide Specificity Required for Synergistic Effect .

[0156] This example demonstrates the importance of selecting specific tetrapeptides to provide the desired synergistic activation of ARE. In this assay, the amino acids from ac-PPYL [SEQ ID NO:2] were rearranged to form a new tetrapeptide ac-YPLP [SEQ ID NO:3]. The test composition and control composition were prepared as described above in the ARE assay and tested accordingly. The results of this assay are summarized in Table 3 below.

[0157] Table 3 - ARE activation and the specificity of Ac-PPYL for Ac-YPLP

[0158]

[0159]

[0160] Surprisingly, as can be seen in Table 3, tetrapeptides with the same amino acids as ac-PPYL [SEQ ID NO:2] but in a different order did not provide the expected synergistic effect. These data suggest that specific peptide sequences are important for providing the desired synergistic effect.

[0161] Example 4: Synergistic upregulation of genes involved in cellular antioxidant and repair .

[0162] This example demonstrates that the combination of nicotinamide, pal-KTTKS [SEQ ID NO:1], and ac-PPYL [SEQ ID NO:2] synergistically upregulates SLFN5 [SEQ ID NO:4], GDE1 [SEQ ID NO:5], MINPP1 [SEQ ID NO:6], and HMGCL [SEQ ID NO:7], which are involved in cellular antioxidant and repair processes. The test and control compositions were prepared as described above in the gene regulation assay and tested accordingly. The pal-KTTKS used in this example was PROMATRIXYL pal-KTTKS from Sederma (France), and the ac-PPYL was SYNIORAGE tetrapeptide from BASF Care Creations (New Jersey). The results of this assay are summarized in Table 4 below. The fold changes shown in Table 4 are based on the sum of the combination (N+P+A) versus the individual treatments (N, P, and A). A p-value of 0.05 or less was considered significant.

[0163] Table 4 - Synergistic upregulation of selected biomarkers

[0164]

[0165] Exemplary combinations

[0166] A. A skincare composition comprising:

[0167] 1) A combination of vitamin B3 compound, palmitoyl pentapeptide-4 (pal-KTTKS) [SEQ ID NO:1], and acetyl tetrapeptide-11 (ac-PPYL) [SEQ ID NO:2], wherein, according to ARE assays, this combination of vitamin B3 compound, pal-KTTKS, and ac-PPYL increases the activation of cellular antioxidant response elements (AREs); and

[0168] 2) Dermatologically acceptable carriers.

[0169] B. The skincare composition according to paragraph A, wherein the combination of the vitamin B3 compound, pal-KTTKS, and ac-PPYL synergistically promotes the activation of ARE.

[0170] C. The composition according to paragraph A or B, wherein the combination of the vitamin B3 compound, pal-KTTKS [SEQ ID NO:1] and ac-PPYL [SEQ ID NO:2] exhibits a synergistic factor of at least 1.3.

[0171] D. The composition according to any of the preceding paragraphs, wherein the combination of the vitamin B3 compound, pal-KTTKS [SEQ ID NO:1] and ac-PPYL [SEQ ID NO:2] synergistically upregulates at least one selected from nuclear factor E2-related factor 2 (NRF2) [SEQ ID NO:3], Schlafen family member 5 (SLFN5) [SEQ ID NO:4], glycerophosphate diester phosphodiesterase 1 (GDE1) [SEQ ID NO:5], inositol polyphosphate phosphokinase 1 (MINPP1) [SEQ ID NO:6] and 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL) [SEQ ID NO:7].

[0172] E. The composition according to any of the preceding paragraphs, wherein the vitamin B3 compound is present at 0.05% to 10% by weight of the composition.

[0173] F. The composition according to any of the preceding paragraphs, wherein the vitamin B3 compound is selected from nicotinamide, nicotinic acid, nicotinic alcohol, and combinations thereof.

[0174] G. The composition according to paragraph F, wherein the vitamin B3 compound is nicotinamide.

[0175] H. The composition according to any of the preceding paragraphs, wherein the pal-KTTKS [SEQ ID NO:1] is present in 0.0001% to 2% by weight of the composition.

[0176] I. The composition according to any of the preceding paragraphs, wherein the ac-PPYL [SEQ ID NO:2] is present in 0.0001% to 2% by weight of the composition.

[0177] J. The composition according to any of the preceding paragraphs, wherein the ratio of the vitamin B3 compound to pal-KTTKS [SEQ ID NO:1] to ac-PPYL [SEQ ID NO:2] is between 500:1:2 and 1:1:0.5.

[0178] K. The composition according to any of the preceding paragraphs further comprises at least one additional ingredient selected from vitamins, minerals, peptides, glycosamines, sunscreens, oil-controlling agents, flavonoids, antioxidants, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliating agents, skin brightening agents, anti-acne agents, anti-wrinkle agents, phytosterols, N-acyl amino acid compounds, antimicrobial agents, antifungal agents, pH adjusters, thickeners, preservatives, and combinations thereof.

[0179] L. A method for treating skin oxidative stress, comprising:

[0180] Identify the target skin region to be treated; and

[0181] Apply any of the skincare compositions described in the preceding paragraphs to the target skin area.

[0182] M. According to the method described in paragraph L, the composition improves the appearance of visible signs of skin aging.

[0183] N. A method for upregulating NRF2 [SEQ ID NO:4] in skin cells, comprising: contacting skin cells with an effective amount of a vitamin B3 compound, pal-KTTKS [SEQ ID NO:1] and ac-PPYL [SEQ ID NO:2], wherein, according to ARE determination, the effective amount of vitamin B3 compound, pal-KTTKS [SEQ ID NO:1] and ac-PPYL [SEQ ID NO:2] synergistically increases the activation of the antioxidant response element.

[0184] The dimensions and values ​​disclosed herein should not be construed as strictly limited to the precise numerical values ​​cited. Rather, unless otherwise specified, each such dimension is intended to represent the stated value and a range around which it is functionally equivalent. For example, a dimension disclosed as “40 mm” is intended to represent “approximately 40 mm”.

[0185] Unless expressly excluded or otherwise limited, every reference cited herein, including any cross-references or related patents or patent applications, and any patent application or patent claiming priority to or benefiting from it, is incorporated herein by reference in its entirety. Reference to any reference is not an endorsement of it as prior art to any disclosed or protected art herein, nor is it an endorsement of any such invention, either on its own or in combination with any one or more references. Furthermore, where any meaning or definition of a term in this invention conflicts with any meaning or definition of the same term in referenced documents, the meaning or definition given to that term in this invention shall prevail.

[0186] While specific embodiments of the invention have been illustrated and described by way of example, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications falling within the scope of the invention be covered by the appended claims. sequence list <110> Procter & Gamble <120> Skin composition and its application method <130> 15964 <160> 7 <170> PatentIn version 3.5 <210> 1 <211> 5 <212> PRT <213> Artificial sequence <220> <223> Description of the artificial sequence: Palmitoyl pentapeptide-4 (pal-KTTKS) <400> 1 Lys Thr Thr Lys Ser 1 5 <210> 2 <211> 4 <212> PRT <213> Artificial sequence <220> <223> Description of the artificial sequence: Acetyl tetrapeptide-11 (ac-PPYL) <400> 2 Pro Pro Tyr Leu 1 <210> 3 <211> 34829 <212> DNA <213> Homo sapiens <400> 3 aaatcaggga ggcgcagctc ctacaccaac gcctttccgg ggctccgggt gtgtttgttc 60 caactgttta aactgtttca aagcgtccga actccagcga ccttcgcaaa caactcttta 120 tctcgcgggc gagagcgctg cccttatttg cgggggaggg caaactgaac gccggcaccg 180 gggagctaac ggagacctcc tctaggtccc ccgcctgctg ggaccccagc tggcagtccc 240 ttcccgcccc cggaccgcga gcttcttgcg tcagccccgg cgcgggtggg ggattttcgg 300 aagctcagcc cgcgcggccg gcgggggaag gaagggcccg gactcttgcc ccgcccttgt 360 ggggcgggag gcggagcggg gcaggggccc gccggcgtgt agccgattac cgagtgccgg 420 ggagcccgga ggagccgccg acgcagccgc caccgccgcc gccgccgcca ccagagccgc 480 cctgtccgcg ccgcgcctcg gcagccggaa cagggccgcc gtcggggagc cccaacacac 540 ggtccacagc tcatcatgat ggacttggag ctgccgccgc cgggactccc gtcccagcag 600 gtgctgcctc ggccctctgg gccctgcggt ggtgccggga cggggcgggg ggagctaggg 660 aaccgcggcc cgggaggac agccgcaacc ggcttccccc acgtctggcc agagccagga 720 ccgcggcgct gggtagagcc gccgcgcttg cgccggggca gggcggggag gggcagcggg 780 gacgcggccg ggtgatccga ccgaccacga gcccgagggc gaacgggtgg gaagttgcgg 840 gaaggtctgg ggactgagcc cgctcgcgtg ggccttgggg gagaatccag ccgcgtcccc 900 gggcccgaga gctgggactc cggagcccct aagtttgagc ggcccggtgg gcggcggggc 960 aagagggggc ggacgctggc cgtctgagcc ggcgcggccc ggcccttccg gggctgcgcg 1020 gctcccccgc ctcggtgccg gcaaaaatgt gcctagtcac ggggccgctc tcgggggaac 1080 tgaggtcgcc ttcgggctgg gacccggagc cccttcgccg cgccccaaga cctccttgag 1140 tgcgggctgc gacgcgctca ccccgctggg ccgtctgtgg gcgcggcttt gcgaagtcat 1200 ccatctctcg gatcactctc tggcagcctt gagctctctt gaaagcccag ccccgggacg 1260 agggaggagc gccttaagtg cccagcgggc tcagaagccc cgacgtgtgg cggctgagcc 1320 gggccccgcg cactttctcg gccggggagg ggttcgggct cgggcacccg gagttggccc 1380 ctcgtaacgc cgcgggaaag tgcgggcgag ggcagtggac tctgaggccg gagtcggcgg 1440 cacccggggc ttctagttcg gacgcggtgc cccctggtgg cgctcaccgc gcgcgtggcc 1500 ttggcttccg tgacagcgct cggttggccg tcacagcagc cctcggttgg ccctttcctg 1560 ctttatagcg tgcaaacctc gccgcgccag ggccaaggga caggttggag ctgttgatct 1620 gttgcgcaat tgctattttc cccagagcgg ctttgtcttt ggatttagcg tttcagaatt 1680 gcaattccaa aatgtgtaag acgggatatt ctcttctgtg ctgtcaaggg taagagttgc 1740 gagtgtagat tagaatttct gttgctttta gtctgttagt aattttttgc tttcagctat 1800 tatttctccc ctgagtactt tatatatgtt tccttttcag ttgagaattt gcctcaattt 1860 cttaacatgt tccccctctt ctgcaggggc agagagtgga acgcttgcgt ttcaaaacac 1920 ttgctaattt ctgtgaattg ttataaaagt gaaaagaagt ttctgctcat cctttgtaga 1980 aactttaaaa gtagatattt atatttctaa cttcttttgt aaatgaattt taggaaaaaa 2040 attggaattc aaggaaatgt gtacttgatg tacagtaat acgtttatgc tgttaaatgt 2100 aaagttttcg gttaattcca aagatctatt gtaaagtttt aagttatgga caatgtatta 2160 attgtgcttt tttccccctt taaagttgtt tgtcttgaac ttttccccag tcttcattgg 2220 gattgtattc ttctggttcc aactagtgaa gaattaaatt gtaccttccg atttatttaa 2280 tagctgctgt tcaagagtta tctataggaa tgcttgtttg actgaaggat atatgataaa 2340 aatgaacttt agtttttctg atttccggaa ttgtctacag ccctctatta tttttgaatt 2400 tttctttctt tgctgtgtaa tataacattc cttatacaaa aatgcgtgaa acatatgtac 2460 cgcattaagt gtgtattttc cattacgtt tgataaaaat aactgctttt ctaccttttgt 2520 atcagacat cgatttgcat atttgaaac agaaaagaa caagaaaatt tagattgat 2580 tttgtttatg attcatatta gattgttgtc atccataag atttgaacag agtcaaacat 2640 tttcttgacc tttgtcaaa aaaaactc caggtgtgaa gtggtagtag gatatagtttt 2700 ttcaccttct gtgcagagga tgtgttgata aacagggcag taaggagc cttagattca 2760 gtatctccat taggtggaag gaaccatcca ttacttttt caagggtgtc ttggagagat 2820 aaagcacttt cctagatgag ggatgaagtt gatttgaa taggaccgatg agattatttt 2880 tagtcaac aaaaaaaaa taggacaggc ctctcatctc ctgaatgaat gttaagcaaa 2940 gaacaacttg actttttaga tatgtgaaaa atctcttgag aggttgtgga agcagcatgt 3000 aggaggataa atgcatact cacatcagtc ttttacgcat taaaaataac tggggccatt 3060 ttgaaatctt tctcttgc cctgggttct tataagcaat gttgggggga aactgactc 3120 tgtctttagg attaccagga aaagttgaaa gccaaatgca tcattttct taatatttgt 3180 ttttattgag gataaatcat gtttaacaaa gctgcatgaa aaaaaggaac ccaacaagta 3240 cattttttt tctgggaatt tcctctgtcc tgactgaaga catttaaagg gggttttgtg 3300 tcaatattc ctccttaact gttcctcaag cctgggttaa cttttcagta tgcaggaaga 3360 atttggcact aagataataa tagataagtt actgggcacg tccctgggtg ccagacataa 3420 ttgcttcaca tgcataattt tacagtaacc tcacgggaaa tattattatc cctggtttcc 3480 aggttgggaa aaccaggcat atagttaga tcaggcatta ggttaggaaa ggttaggaga 3540 gaggcataga gaaaggccag gacctgctaa ggtgaccata ctattgagtg gccaaggtag 3600 cattcaaaca ggtttgactc ctgggggct ctaatcacca cttccagact gtaccaaaac 3660 tccttaaact ctaaatagga agaaaagctc acactttaaa aagtgggtaa gttgagattt 3720 gcctattctg ggggaaggag aggccggaat ataaaagatt aatgtctgca gcttttccat 3780 ttagcaagac attaatcac tgtatgtgac gtggggaggt ggaccttgtt aaatacaggg 3840 agagtgaata caatccatca atggtaccca ctgtggtcct tttaaggaag acacagaggc 3900 ctcggtggat tcaatttaga aaggcaggac tgttttttgt tttttgtttt tttttttttt 3960 tgagatgaag tcttgttctg ttgcccaggc tggaatgcag tggcctgatc ttggctcact 4020 gcagcctcta cttccccgggt tcaagtgatt ctcctgcttc agcctcccga gtagctggga 4080 ttataggcac ccactgcccg gctaattttt gtatttttag tagagatggg gttttaccat 4140 gttggccagg ctgggctggt ctcgaactcc tgacctcagg tgatccaccc gcctcggcct 4200 cccaaagtgt tgggattaca ggtgtgagcc actgcgccag tctgtttctt aatataataa 4260 tagttttaaa aatttctgat gtttggcaat gtccaagatt ctgcctcaca tttttcagaa 4320 actgccttt ttcttaatta aatctcttag ctactggagt ctttgccttt gtttgccttg 4380 ctacttggta catttcttct gttccattgg ctcttttgt tttgaagtag tgctcaaaaa 4440 taagtttggt agtaagaata tggtgaagag tgtgacagac agggttaaac caggctgaag 4500 gaagagagc agaatggga aaatttgagt tgaaaacagc tagcagaaag ctgatggcgc 4560 aaattcaacc ctaatctcat gttttggcac ttctgaacta tagcaagcat aagggctcaa 4620 ctcttatcta gttgaagctt acttgggtct ttgagaatag tacatctcaa aattaaacac 4680 tttcttagtc cttattgtta agttgttttt ggaattattg tcttatttgt ctgaattaag 4740 tgtgctgcag gacttatagg atctgatgga tgatttgcct aaaagttggt ccaggtcaac 4800 ctcagggcat ttaaatgctt ggtccagcca cttctgaaa gttgactgaa atatgttgca 4860 cagcagggta gaggaggaca agtttactag atgtcatttt taacctgctt gtcttcatct 4920 ctgactgtag aaatgtatat tcattataag tttgccacaa atagagaata gagtttattc 4980 tttgatcatc taatttctag gagctattga aatttcactg ctacctgctt ttaaataagc 5040 gccaacaaac attattaaa agggctttaa ggtataggcc aagatttatt caattgctaa 5100 tggtatgttt tctgtaaatg aaagcaaaaa tatgttcaag tgtataat taaatattaa 5160 cattcagaaa cttggagaaa tacagatggc tttttttttt gagacgcagt cttgctctgt 5220 cgcccaggct ggagtgcagt ggcatgatct ccgctcactg caagctccac ctcccgggtt 5280 cacgccattc tctgcccca gcctcccgag tagctggtac tacaggcacc cgccaccacg 5340 cctggctaat tttttgtatt tttagtagag atggggtttc actgtgttag ccaggatgat 5400 ctcgatctcc tgacctcatg atccgcctgc ctcagcctcc caaagtgctg ggattacaag 5460 cttaagccac cgcgcctggc ctagatggat ttcttgtacc agactatacc ctagacatga 5520 aaacaagact gttaaacaaa atcctgtgct acctaaagtt tgagccttct gtgtgtcagt 5580 ttctgccata ataaataact cttaactatg attattaagt atattaagaa ctttgagtag 5640 gggaggcacg tttaatcatt cgtttttacg gcatatgtac tataatacct gtgtgttgca 5700 aatcctggta tttaaaagtc tttttgtgta tttgagcatg taagtttatt tggtccaaac 5760 tgctggtact agtaaagaca agtccagggc ataagtagga cttacagcac caagttcgtc 5820 tttttttttt gagacagagt ctcagtcggt cacccaggct ggagtgcatt ggtacagtct 5880 gggctcactg caccctccac ctcccgagtt caagcgattc tcctgcctca gcctcccaag 5940 tagctgggat tacaagtgtg tgccgccacg cccggttaat ttttgtattt ttagtagaga 6000 tggagtttca ctatgttggc caggctgatc ccgacctcag gtgatgtgcc caccttggtc 6060 tccgaaagtg ctgggattat aggcgtgagc cactgcgcct gacctccaag tccatctttc 6120 aaaggctctg ttgaaattg actcttgaga gtcattacag tccatcaaca gcctgtattc 6180 tgaatatttg ttttaattc taagacaatg ctaaatagcc attccaaata aggtgagaac 6240 tgagacttta gggcctgtat tatcagctgt acactgacaa gctctgaact ctattgcttt 6300 ttcaaatcag agaagaaaaa tgagtaagaa aagaaaaata tggatcactt aggctttgat 6360 gcctctctg agtttatagt gtttaccttc tgtattactt aggtgatcct cctaatggc 6420 atttaaatc tctgttgata cttgtcttac ttatgtatct gtttttttttt cctctatagt 6480 agatagaatt tatagatata tatgtatttt aaagtaagat acaatttacg taccttacaa 6540 tttacccatt taatctaatt cagggttatg caaccctatg aatttagtag tttattcata 6600 gagttatgca accatcactg taatcaattt tcaacaccct caaaagaaac cccatatcca 6660 ttagcagtca cttcccattt cccctcaact ctcctggccc ctggtaacta ctcagttatt 6720 ttctgtacct atggatttgc ctattctgga catatcatgt aaatggaata gcatgtaaat 6780 ggaatcatac agtatttatc cttctgttgc tggcttcttt cacagcaata tgttttcaag 6840 gtttaaaaat gttgcaacgt atatcaatag cgtcattcct ttttatggct gcatactatt 6900 ccattgtatg gctataccac attttattta tccagttgat gatcatttga gttgtttcca 6960 ctttttatgt ttctgtttgt ttcttacagc agtggttctc aaactgttgt atattagact 7020 caccatcagt atttaaaaaa ctaatgccca ggccatatcc ctcatgaaat caaaatctct 7080 gggggtgggg cccaggcatc actatttttt aaagattctg aggggattct aacgagcagt 7140 caggtttgag agccagtgcc ctagggcagc agtccacaac ctttttagca ccagggacta 7200 gttttgtgga agacagtttt tccatagaag gaggtagagg atggtttcag gatgaaactg 7260 ttccacctca gatcatcagg cattagattg tcctaaggag ctggcaacct acatcccttg 7320 catactcagt ttacaacagg gttccggctt ctctgataaa ctaatgctgc tgctaatctg 7380 acaggaggtg gagctcaggc gggaatgctc gcctactgct cacctcctgc tgtgcggcct 7440 ggttcctaat gggccactga cccctccgca gccagcaggt ggggacccct gccctagggg 7500 acccacctca gtgcttggta tccattgaag tatatagtga tttagaaaat ctggttagga tgtcttattt aaatcatgaa agcaagtgct tttgtctttg atcattgccc ttcacagcct 7680. acctacattc aggaactgtg tttcaaagtg cctggcgagt gtttgaaact cactaaatat fatheracctg ggctcattaa acccctccag aagattttggg taactttgtt atgaaagggc ttccctgaag tgggtcagca ggattgctct gtgttttttc aggaatgtgg cctgtgataa cttgcaatct agattatttg gaaatagcac tgagagaagc cagtgaggac agaatgctca gaagcttggg ataggtgttg aacatcctgg aggccaggac ggaacactgt cttactctag gaagctgtgt tcctgggcct cattatcttc ctccgttaaa aacaaaagac ttaatctcc acagcagctt tcagcaactt cattttttgg ttctctgtat ctgcctgata aagtcccact ttgtagtggc tcccacttat atttacctga atggcttttg ggttgacata 8100. tttggaaact ggggctaact tccaaactgt tggcaacttg tgtgtgggtg tgcgtgccac 8160. agcacagcag tcccacttga gagacttgat ggtgtggtgg tggttggggg gcttctgaag ctggcttagc cccagcccta tacacccacc ccacagatgg tgggaacaag cccagaagag 8280 agtgggtaac tctgtccact gtggcctcca cagccaaggt tgccaggcag agctcgcaag 8340 gcccaattcc agtcttgtct ttgaccgttg cccctttgtg ttgggggggt gtatttagtc 8400 acctttctgg aagcatgctt ttctaattct agtcatcagt agtttgttgc tttaagattt 8460 tgaaaatggt atcctgttat tttacttagg agtttcgtat tgaatggtgt acataatgtg 8520 attcaagtac ctcaaaacag aggacttca gttaagattt aggctctatg caacatacac 8580 ttcttgcatt ttctcattca atgtcctttc cttttttttt tttttttttt ttgcaagaat 8640 gtagctgaca ttcagagtag attagtacct tcaatgtctg tgtgaaagaa atgaccttaa 8700 tatgaggaca atattgactg tgtatttagg gggcccactg ttaaggcata tagaattttg 8760 ctttatttca gacctgacaa tctcttgtct gctctgcttc cgcataaat tatatactg 8820 cacatggatg taaaacccaa cctattccct gcctgaggga ctagaataga gggaagaatg 8880 actatagttc tttgttgcct tttgtgaagg taacaggcac agaggtatga tgcatgatgg 8940 aattatatac ctcttcttga ggtgtttgag ggctgactaa ggacctgtac ttttttttg 9000 gtttgtttg cagtactggg gccagggagc cttgctgttg tgtctagaga gtgttgaaga 9060 accatgaata ttcgcaaaa agaaaataat ttttttaacc attaaaattc ctggtagtga 9120 cttcctctgg caagtaaaaa actctcattt tccttaaaaa atgagagttt tttacttgca 9180 ataggaaaac ttgccaattt ttcaagttat ttttattctt gatgattctc aatgagacat 9240 attaaaata cacatagaaa aaacaaccgt aggccaggtg cagtggctca caccagtaat 9300 ccaacactt tgggaagtca aggtgggagg atcactagag accaggagtt tgagatgagc 9360 ctgggcaaca tattgagaca ctgtctcctc aaaaaattaa aaaaattagc tggatccagt 9420 ggtgcacacc tgcaattgta gctatttggg aggctaaggt ggaagaatag cttgagccca 9480 ggagtttgaa ggtgcagtga gccataatca tgccactgta ctccagccca ggcaacagag 9540 taagatcatg tctcaatgaa aaaaagaaaa atcaacccta gtggactgga acagggctgg 9600 tttactttgt gtcagctgca gtgcccccac tcgccaaccc acatgttctt ctcctgctgg 9660 ttcccaagca gagaccagaa ccaagaatga gaatcatcct gtgggtgcag gttgtatctt 9720 atcctccaga gacagcactt caccctctgt tagaaacttc tttaccacac tgcctgtttg 9780 gtgaaatcct tagggcagtg acttccaaac tgtgatccag gggccaccct tggtgggagg 9840 atcaggaagg agggggaatg tatcttaaga aaagttgggg gaagctcata tctcttctcg 9900 ttgatcctga gaagtaaagt ctttcctcct cagagagatg cgggtagaca tgactcgcct 9960 agatagaagc tcattcatct ccctcccttc tgcctctgca ggactcttgg aagtctgggt 10020 ccccgggagt atgcggctct tgctctgtgc tacaggtttc caaagttcac ttgataacag 10080 tacaattgtg ctgtaaattg tgcagtaatg gagactgagg aaacaattag tctttcatct 10140 tcattcatgt taccagctca cttcctatgg tgtgaaaaga gccagacttt ggagttagga 10200 gacatctgaa tacagacaga actggcaaga ttatgggaa gaaaagggaa aagtaatgaa 10260 tattttcaaa gaggttaagc catttggcca ggacaacact gcttgcaggt agcagaactg 10320 ggattttgac tgtccataat ccctattctc tgcttgttt actctcttcc tctcttcttt 10380 cttttttcat tgtctaatga cctacagaca ttctgtcagc tgctaaagaa tgagggactc 10440 ctttaaaag attgatagga cagtgtcgct acttaaggag ttccttccat gtggaccagt 10500 gggggcgctg ttgacgcatg ggggctggact tctctttgga gcagagtcct gttccacgga 10560 tcgctgtgac aagcagaaag tgccccaccc cacctccata caattcctaa tgctcctggg 10620 tgatacaacc gccccagtgg aagcacggtg gtgcatggac ttctagagac catttgaagc 10680 caggacattg ctgcttgttc ttaggaaatg gcagaatatt actttcttgt tttttgtagg 10740 gaagcctgcc atctcaccag gtggcagctt gtttatacct tttatcctaa cctgaagcag 10800 gtgatgggac agaggtcatc gaatataatg aaagtgccac aaaggtagag tctgggtata 10860 tttttttat gcaggtagag tgacttgtcc agatcccttc acacagagca acatttaata 10920 tggtaattgt tactgctgaa gttggccatt tctcggacct acagctgcaa ggaattggta 10980 acaaaaggat aaactaaaca ttgttactat tttaatttc aaggagatga agtttaaaatc 11040 atatatgtca tatctctctg gggcttagcc acctttctg ctgggcactt tttgaagaag 11100 tctgaatact gagataggag agtaaagggg ggaaagtaag tttgcccact tctcatcctt 11160 tttctgacca tcagcctgag ggaagtaact agaatccgct aagaaaattc acttaatcag 11220 cagttgattg attgttatat tgtccacatt gcaaaattct ttaaaggata tttgaagata 11280 tttcacatt tgttctctta caatctattg tattgttat ttgaaggggt gagtgttaat 11340 agttcttaag atatcgtact ttatttccgg tagcatatcc aagaaataat ttagaagtat 11400 tgttaatggg aatgatgtta aataattttt ctatgactag tagttgggac atatatgata 11460 taaaacatgg tatctttgtt acttaagtaa tttgaactct aaccccatat atcttaggta 11520 gacaatgaaa atactgaatt gttagtctaa ataataca cgtactcatt ccgcaaatat 11580 ttattaggta tctacacacc ctaggaatct ttcagggcat gaagctgttt taatcttcca 11640 agataatgca gcacgtatcc cccttgaggg acatttgttt ttcaaattgc tcctctgtgt 11700 ctcctctgct taggatatga gttcctctaa gactgtattt taatcttttg tgtaattctg 11760 atgtctagcg ccatgcctgg tgcttacgta atagttgctc agtcagtttg agggtgagtc 11820 cattaactgc cctctaggag cttgatattt aataaact agtctgtgat acatgacaat 11880 gctgtgacag tgcagatgag aaaatgtgac ttctaactgg ggtgctcaga gaggatatcc 11940 tggaggaact gccattttaa ctagactttt cttttaagca ggtagattttt gtttggttca 12000 ggcttcagct ggaagcccaa gcaatggtgc agatatgagc tggactatga cagactattg 12060 ggccagtggg gctgacaagg ttaacttggg ggttgccata gagggccttc agtgctcatg 12120 tgcactgttt caagtttgta cagggcatct ggaaaccatg gaagaagatt ctggaaaggg 12180 cagggcaggt aaactggatg tggataggaa gttactgtgg caggtgaatt ggaagatgga 12240 caggttggag gcagggagat ggtgagcggg ctcctgccaa ggtgtaggtc tgagcattgt 12300 tgtgacggct tagttggttt gacatcagca cacagattga ggatctgtca ttgtaactct 12360 aaattgtatc cttgttagac atgtaaaaat aactttttag agcctccgtt tttaaggagg 12420 gaagtggatt gtgctcaagc ttgcatgctc cgctgttcct gtgctttaaa aatactcatc 12480 caccagtgtg gtcactgatg aaaggggagg aaaaactagc cagaagttgc cattttgctt 12540 aaagaatgga ttcatttctt cctcaaggtg gcacagagag agttctctc ttttgcccc 12600 tctcttagat tgatttacta tttttagtaa attctaacag tctgatcctt gcttccaatt 12660 acaatgatta gcaatatttg cccaagacaa gaaaaaacaa tttcctctct tttctctcct 12720 atgagctttt cctgtgagcc ccaagcagac agatgtggac atctagcaat gctgttaaca 12780 acagctgcag tccgttggac tctctgcaac actgggcacg gtacaaagtg ctctgacaaa 12840 ctcttctgcc ctttgcaatc cttactacgc cctgtgaggt gaggagtatt cttcctgttt 12900 tgtaggtgaa gaactgaggc aaagagaggt tatgtcatta gatttcacaa tagggtgtgt 12960 ttccgtttca tcatctttag attgatgtta ctgtgacatc atcttcctag aattaaaaa 13020 gtgaactggg cacaggaaat agcacatggc acaccttcag caaatggtgg ttgtgatcat 13080 tttcatt ccatttcttc ttgaaaaaaa tcccttttt tttttttt tgagacagag 13140 tctcactctg tcgcccaggc tggactggtg tgatctcggc tcactgcaag ctccgcctcc 13200 cgggttcacg ccattcttct gcctcagcct cctgagtagc tgggactaca ggcacgggcc 13260 accacgcctg gctaattttt ttgtattttt agtagcg gagtttcacc gtgttagcca 13320. ggatggtctc gaactcctga cctcgtgatc cgcccacctc ggcctcccaa agtgctggga 13380. ttacaggcat gagccaccac gcctggcaaa aatccctcga gttccagtgt aaacactcac gccctttttt gctgtttgct ataaacctct cattctcctt ggtcttcttg tccttgtgtg 13500 aggtcctggt tgttgtggag actgaggtct tctgagacag aaaaccaacc ccatagcagg 13560 cctggtgtgt gccctagaat ggcagaggcc ccacacgttg ccccggctcc tctggaagac 13620 cctccagcct gtctgctgga ttccttgtac ttatgaggat tgttaaacca tctcatagga ttcctttcca gactcagccc ttcacttgtg gcagcatttc ttactctgag gttctgggcc 13740 tagaaaccca gtgtccatag gcaaggtcta gggacagaga gagtttgtag aaagtgggaa tgcatcagtg gaaggctaaa tccaaacagg aactgagctg gcctgggtgg ctttgtcctt ttgccatctt cgtaaccctt taaaggcttt aagacacttc ttttgtaata actaccccaa 13920 ctaaatttgg ccagagctgt gaagggaaag aaaatctaag acccttgagg gagatgacag 13980 ccgaacgttt tacattttta ccacctttgt tgttgccatg cacagctgat acataaacaa 14040 gtaatggcct catcttctat tcttttattt actggttaga cccagaaccc taaaaggtag 14100 atgcttctca tggtcatttg gcatttgcaa caggagctga atttattaat agtactaata 14160 cctcatcctt ggacatcctt gggttgtccg atatttttaa ggggcattta catcctttgt 14220 ttttcatatg gaaaactttt ccgtaagggc tggtatcatc ttggccttcc attgcaggaa 14280 cagcacaggg aggttcggtg gctaggccac agttacccac gcagctaggt agcagcagag 14340 gccccacctg gcaccccctg gcttcctaag cacatcgcac tgtgcagcct ccctgaggaa 14400 gcctcgagtg gataggaact ctggttcttt aagataaacc tgagttggat ctcactgtca 14460 ccatttatca gatggggcga tgtcttcagg caaaagtact taacctctct gtttttgttt 14520 ccttactcca aaatggtaat gatcatacta ctacccacct gggtggattg gtgtgcatat 14580 gaaggaggtc atgggacaa gtggttgaa gagtgttgag cacatagaa gtacagata 14640 aatggtggcc attgttac tacttagact attcatact tgtctttatc tgggcttaga 14700 atcttgacac tgagatttt cattctcaga tcttatatg aaagcttacc aggtaacac 14760 tacccaaca taatttatta gtgggttcat acatgtgaaa gcagttgaaa tacaatttct 14820 gaactccgggg ttaatttata tccttagttg gaacaggtag tacctccca gcacctagg 14880 cctctcactt ctatccattc ttcagatgac ctttgcaata atcatgtaa ttgaatagca 14940 tctgcaccat aacattgttg aacatca aaatgatcca tttagccatc atgagccttc 15000 ctagtaattc agactcacac cagttctttc aggttattga gtagcttta caaayattg 15060 ctaacagtac aaatactgtc tcaggtattt tggaagggtg aatttccca ttgatttcag 15120 tgtatcttta ggaggtaatt tgcaaaccg aagagttgg ttccgtcaa gtcaccccta 15180 aggagtgtgg aggaccacat tgtaggttta tactgcactg tcccatgc tgaaatttg 15240 gctcatgcaa ccaggact gatttttaa ttcgttaaa ttttgattta aattttaaaa 15300 cagaaatagt ataaaatatt tttctgttaa ataccttg tagtgttggc aagactacat 15360 ttcgtgttac catgctgggt aagatttctt gtagtgtgta ttgtgttttg tcacctcgtt 15420 aaattttc ttattttggt tgcatgttaa aaattttg gatatattgg gttaataaa 15480 tatattgtta aaatttaatt cacttgttta ttttttgtt ggtgaggcta ggctactaaa 15540 aaatttaaaa ttacccatgt ggattgcatt atatttctat tagtgctgct ttagctgcaa 15600 gtagcctatt taaaaaaaat cattatttc agacttatgg acttcataga atcagaggta 15660 tttagaggaa aggatctgg gggtcaccta atccagctcc aacattttgc aagtgataag 15720 accaaggcca gaggctacaa taaaatgact gacctcctcc cagatgggga ctggatccca 15780 gtggctttat agccttttgcc ttggatcctg gttttacttg gaacatagc agacatcaga 15840 gctgcagaga acttctacca gatcggagt gagaaaatg ccttatttat ttattatt 15900 atttattat ttatggagac cgggtattgc tgtggcctag gctgtagtat agtggcagaa 15960 acatggttca ctgcagcctc aacctcctgg gctccaggat cctcatgcct caaccttctg 16020 agtagccggg gccacaggta cgcgccacca cgcctggcta ttttttttt tctcttttgt 16080 agagactgcg tcttccatgt tggccaggct gatatcaaaa ctcctgggct caagtggtcc 16140 tcctaccttg gtcccccaaa gtgctgggat aacaggtgtg agccatcatg cctgttttgg 16200 cagtttttag gggcccacgc taattttgag ccaggtttgc gcttgataat gtaatgctgg 16260 aggctgggca ggggacatga tctgcctgaa agggctgaga actgggaggc tcttattcct 16320 atagtattga gagcaaaggc acagctcttac agaaccacac aatattcaga gcttgtgggt 16380 tggagaagga aagtcctctg aaaaataaaa aaaagagtac agaggccaga ggcggtggct 16440 catgcctgta atgccagcac tttgggaggc ccaggcaggc ggatcaccta aggtgaggag 16500 atcgagacca gcctgaccaa catggagaaa ccctgtctct actaaaaatg caaaattggc 16560 caggcatggt ggcgcatgcc tgtaatccaa gctacttggg aggctgaggc aagagaatcg 16620 cttgaacccg ggaggcggcg gttgcggtga gctgagatca cgccattgca ctccagcctg 16680 ggcaacaaga gtgaaactct gtctcaaaaa aaaaagaaac agagtacagg tcagacattg 16740 ggcaattttc tcataacaat ttcataggcc attaatttgg ttacagactt gaatagcaca 16800 caacagttct ctaagggtca gtttccaaag taattcctaa tatttaatga atttttaagt 16860 gatagaaatt gcagtaggaa agtctagctt gaaatctaat ttgtgttagg ttgaccaggt 16920 gacaaccacc cacccctgga ttctgctcag ttaggtcaga cctggggcca gttgcccatt 16980 tagcatctca ggcctcagga tcctcattta taaacctggg gtttgaactg cggtctccac 17040 gatcactgtc agctctcctt agtcagttgg ttgttctaaa tgtagtttag tggccagtaa 17100 acacctgttc ctgagtgata catctttaag gagccggtag atgggtcaac ctggctggac 17160 ttgctttttc aagtctgcct tgtctattag aaaggctgag cttactgatt ttgcctgtca 17220 cgtttgagtg ttcctgagac tttgcccagc ctcggtctta tctgcgggta ccccagcctc 17280 tgcattcctt gcccctacaa aatgtgctgc cagttccaaa ggcacaaatg aaaattagct 17340 tggctggagc atggctaggc acacaccagt ggttaaagaa atgctgtttg ctggctgaca 17400 cttctggagt ggaagtttat tcttttttct tttttttttt tttttttgcg gggtggggca 17460 gagttttgct cttgttgccc aggttggagt gcaatggcac gatctcggct tggagcgatc 17520 ttgggtcacc ataacctccg cctcctgggt tcaagcgatt ctcttgcctc agcctctgga 17580 gtagctgaga ttataggctc ccgctaccac gcccggctaa ttttttgtat ttttagtaga 17640 gacagggttt caccatgttg gccaggctgg tcttgaactc ctgaccttac gatccacctg 17700 cctcggcctc ccaaagtgct gggattacag gcttgagcca cggcgcccgg cctttattcc 17760 tttctttggc ctcaatttta ttgttaagag atagtgggaa gggcccaatt ttgaaatgat 17820 cctggaatta atgtaggagg ccttgtataa gcagttaatg tgtatttatt gagtgggtac 17880 cctgtgccaa tatgatacaa ggtgtgaagg acacatgagt tgggaaaggc atggggaaat 17940 gcacgctcac actgctggtg cgagtgtaaa aggtacagtc tctatgtagg gctatttggc 18000 agtatatact ctttgaccca gcaactccac tttagtat ttatcttagg gataccctca 18060 cacatttatg aaatgattta tatacagga tattcattat agcaattt gtaatggcaa 18120 aaagaaaaaaagtcagatg ggggactgat taaatatta tgttattag taatactgtt 18180 tcagtacatc tgtgtaatga aaatgtcc agtcattaaa atagtgagg caagtctgg 18240 gtgcagtggc tcacgcctgt aatcccagca ccttgggagg ctgaagccgg aggattgctt 18300 gagaccagcc tgggcacat agtgagaccc tgtctgtaca aaaaaaaaa aaaaaaagta 18360 aaatattagc gctagt gcacatgcc tgtaatctca gctattcag ggcttagt 18420 gggaagattg cttgagccca ggaggttgag gctgcagtga gctgtgattc tgccactgca 18480 ctccagcctg ggcaacagaa cagacccta tcttagaaaaaaaaaaaaaaaagg 18540 gandacttac aactctgtgc cctgatgtag aaccatctcc aaaatatatt aaatgagtgt 18600 gggatactat gcttatatgc gattgtgtgt atttaatggc ttcctaagaa aaaaaaaa 18660 aacctgatac tagtgattgc cttggaggag ggtaactggg aaattacttt tgcaactttt 18720 aaatcttata ccatgtacac ctggtatcta tttttaaaaa gccattttca tgccctaaat 18780 gagtttagtc agaccatagt aagaaaatcc tgtaagacat acaaagtatg gggtaattac 18840 tggctttatg ggaagactga tttcaatgca aaactctccc tatgcaaggg agttgtcctg 18900 atttcaatgc taagctctct ttaggcaagt tacgttggcc tgatttgcct gttaagtcgt 18960 atggggcagg caagtctgag tgtccagagg gcagaccttt aactcttagt ttcctgcctt 19020 gggagaaggc acagggctaa agtggtttcc agaacgtgtc tgttgtggtg tgaacaccaa 19080 ggagcagtgg acaagcttcc caggctcaag gtcagaaggt ctggactgga gtcctgcctc 19140 tgctacttgg tgaatatgtg atttggggca ggttgcttaa tccccgaagc ctcaacgtgt 19200 tcatctagaa atgaagatta caggctggac gcagtggctc atgcctgtaa tcccagcact 19260 ttgggaggct gaggcaggca gatcatctga ggtcaggagt tcgagaccag cttggccaac 19320 atggcaaaac cccatcccta ctaaaaatac aaaaattagc tgggcatggt ggcaggtgcc 19380 tgtaatccca actactcgggg aggctgaggc aggagaatca cttcaaccca ggaggtggag 19440 gttgcagtga gctgagatg tgccactgca ctccagccta ggcacagag tgagactctg 19500 tctcaaaaaa aaaaaagact acaatacctg gccaactcc ctcatgctac tgtagtgagg 19560 ctcaatgag atagcaccca tgaacactcc tgtaaaccat gaagtagca aacaccaggt 19620 gtaatagaag ctgttaggta cctgtgaggc cagcagacaa gagcagaga tgctaattta 19680 aaagaatta aggtgagca aagatcttt ccctctgcca ataacttgg caagagttgt 19740 aaaattagaa aagtagaccc ttagtagtttt gataatcctt tgaccctga ccctgcacaa 19800 atgatctcac cctttagacc tgttccctta ttgcaaac agaggggct gtctgggtga 19860 ttcctgtggt cccttccagt tgtagcgttc cgtgacagtg tggcattaac agtaattccc 19920 atcttggctg agatgatga gtcatactaa ctgaaaagtc aaatacgag gagaagtct 19980 ctttatgtat gagaatttc ctgagctag agactcagag cctcttgggg aggagatgag 20040 ggaaaacatt gccaccacca agaagggaga cgaaggatgt ataaagaga tggagatgta tttacttttt tttttttttt tttttttttg agacagagtc tcactctgtc cttctggctg gagtgcagtg gcacgatctt gggttactgc aatctccacc tcccaggttc acgccattct 20220. cctgcctcag cctcccaagt agctgggaca caggcgccca ccaccacgcc cagctaattt tttgtgtttt tagtagat ggggtttcac cgttagccag gatggtctcc atctcctgac 20340 ctcgtgatcc gcccgcctcg gcctcccaaa gtgctggggat tacaggcgtg tgccaccgca 20400. cccagccgag attatttact tcttgtgtgt tcttgccatc tccatagcct cctttgcttt 20460 caaatgccca cttgggctgg gcctttgga aatagatttta acccttgttt attggaagga 20580. tattcacaca gtaggccagt tatacacttt gtggcagtcg ttacctcttc tgtgaggtct ttctgtgcag atttagtggc acctcctcca tgctgcctgg gcttctactt gcttctcatc 20640 actttgtctc ataactcaga tcagagactg tgtcttactc atctttgtat ccctggcatc tgagggggtg gtatctgatg ggtagtgga ttagtgatcc acttagggta tttacactaa tcttgttgat cttgactact acctttata ccaccaccat tctacaagtt ttaacttttt tttttttttg agacagagtt ttgctcttgt cacccaggct ggagtgcaat ggcgcgatct 20880 tggctcactg caacctctgc ctccccgggt tcaagcgatt ctcctgcctc agcctcccga 20940 gtagctggga ctacaggcac ccgccaccat gcctggctaa tttttttgta tttttagtag agacggggtt tcaccgtgtt agccaggatg gtctcaatct cctgatcctg tgatccacct 21060 acctcagcct cctaaagtgc tgggattaca ggcgtgagcc accgcaccca gcaaggatct tttttttttt ttttaaagct aagtgtttta tacatataat aatattgtta aataaatgta tctaaaattc ataccaccag cacacaaggt ctccggctag cagcagtaaa tggcatttag tacttactta gcccccaagc ctggatgact gactatactg acttattatt acttttagct atttgtaggt agttacatct gaaaattgac caggcacagt ggttcatgcc tgtaatctca gcactttggg aggaccaaggc aggaggatca gttggggcca agaatttgag accagcatga gtaacatagc aagaaccatc tctacaaaa aaaaatta accaggcatg gtgatgcatg 21480 ctacttggga ggccaaggtg ggaggatcac ttgagctgg gatttagaag ctgcagtgag 21540 ctaggaaggt gccactgcac tccagcctgg gcacagagc agactctta atctcttta 21600 aaaaaaaaat ctgaaagga ccccaaggat tgaacttat ctttacattt atctttacaa 21660 atccaggatc aaagagagg gtaaaggatc acttggggag tttagaagtg gcagaagtat 21720 ctgtagaagc cttacggtgt gatgtgctg gattgtgtgt gcccaccctc atgggggact 21780 tccttggagg atgaggtac accagcatgg gcagcaagc tgtttgacct caggtggag 21840 atctgagcca cctggtcagt ccatgcccag ttaatttcta tggaggttg gtaagtagg 21900 ttaggggtt ggatccaatg ttcctgaagt ttctgttggt aatggcag gggtcggggtc 21960 gggtgtgggg agggttggat cattctaagg gcagtacaag acctaatccc aaggtgaga 22020 agttcctctc tgtggaggac agcatttaga accaataca tacatggctt gttcaaaat 22080 ggggaagaga ttagaaaat ttactaat gtttgctgt caaccaagc cattctctca 22140 gcaaagtagt gaaaccctta cataagtcct ttgaagccta gcagcagtat cctactcaaa 22200 cacaaaccac caaaaaaaaa acaaaaaaaa aacaaaacct ccttggggac tcagatgtga 22260 acctctcatg gaaaattcag taccatgtgc tttttgtagc aggtaggatc acctgctgtt 22320 ttggaaatta actttttttc tgacatcttt ttgaccgaac tctgcatgtg cctcttgaga 22380 aaataatcca aattcttgct ttcttcactt tccagttttg ctttatcttt gcatcatgct 22440 ctgcagttta cagacaagca taatgggtga gagttccagt aaattggctg gatcatattt 22500 cttagattga gtcatgactg aggaacttgt ttgggaacag gaagcagccc atgaaaatgg 22560 ctgcacatag taacctgcca gattgaagaa accggaccac tttctagtgg aaagataaaa 22620 gggcagaaaa atggttctat aactcaggga atggtaaatt tgtgaactag ggttttaact 22680 tgttgaataa tacgtctttg tgtgtatttg ggctttttta tgctgttaaa agtctctagt 22740 tattcaagat aagggaaagg aaaacttgga ttcgtggtaa ctgttgctac ctcttaaatg 22800 tctctgctga tgtatacaac atgttgctag gccagttatt ttttttaagg cactgtagtt 22860 acatagaaat aaacctggca acatttacac ttggcctcga taggctgtaa ggcccctttt 22920 gtctccagta ttctgtgttt ctgtatttta atcacctact ttacacttac tgtagcaaca 22980 caatcaagat agcaaatcag tctaataaaa ccaaaagtac tggaatgtgg gaaatagaaa 23040 gaatgaccta gaattcttgc tgagaaaaca attggtattg ctatattctt gtaatgcagt 23100 gtgagagaag ccagagaagt aaataggcag atacatatct atgaaatgta attagtcatc 23160 agcaagatgt attttaaaaa cacatctgct tggtgtcatt ttgctttatc tataaggat 23220 tacgactgca aggcagagat ttgtaaatga aggagatctc tgttgttttt gttttgtttt 23280 tgctttgtt ttgttttaag acagggctgg agggcagtac atgatcatgg ctcactgcaa 23340 ccttcatctc ctgggctcaa gtgatcctcc cacatcagtt tcccaagtag ctgggactac 23400 agcagtgtct caccatgtct ggctaattttt taaattttt tgtagagttg aggcctgtgt 23460 tgcccaggct ggtctcaaac tcctgggctc aagtgattct cacacctcag cctcccaaag 23520 agctgggatt acaggtgtga gccaccgtgc ctggctgtta ttttatcaat tcctcaaat 23580 tcaagcatgc cctcaaatat tttgcagcc tcatatagct cttaatttgg ttatattca 23640 tccagatggt aggatatgat tcatgttcca cctggttttc ttcagaaata cttagacagt 23700 gtctatggaa aaaaacattg aaccagattt agctttagg taatatat aatcacctgg 23760 gaatattag aagaatgaaaaaaataa tcaagtgtaa cttagactct 23820 gatgctggt aactaagatt tggatgagg aaggattctca ggggaatac atttaaataa 23880 gattttttt aaatggaat acatgatttt aagaaggaat aacttaagac attccaactt 23940 tatactacat gaagtaaa agatchagga tcagttttct ctttggagca aggctcagtt 24000 tcgctttctg ttgagagtta gtagtgtgta taattaattt ttttacag tttattg 24060 aaatttattt ttagaggaa atctcccacc accttcctgt cattctcagg gcaagataga 24120 gggtaggaga gggaagggag actcggggga atgggaggtg caagccttaa ttagacattt 24180 gagtgtctaa aagattactt ttcatttcaa atactttgtc tcagtttact gaatagcttt 24240 aatttaggac agggattgta ttatctttgc tttatctttt ccaatatttt ggatcatcta 24300 agcatgatag atgctggttt attcaaggca ctaaaattga cttgcaaaag acatatttaa 24360 tatggattct gtgttcaagt cctttcttct ttgtttatcc tggtacaaag atgtttgttt 24420 taaagtggta tgagttaatt gtccaacttc agatttccct aaaatgtgta acagattacc 24480 cagttggcaa atgatgatat atatttttta aacatgaata tttctgttag gccagatggt 24540 gatttaacat gaattgtcca acatttgtgt ttcttatcaa attgtcttct tttgtctaag 24600 ccaagctagc aacataattt ggaacacact caggaatcac taaaggacaa gagcaaaaaa 24660 aattcagaca ccaagtggca gacggcattt gctccatatg ccatgcaaag gctcctggcc 24720 agtgctcgca tggcccttgg gaagctttct cacccgttgt aagaaagtat ctgtgcagtg 24780 ctgtgcaacc catctacctg ctttcctctc tctacccaaa ccctacttat ctaacacttt 24840 gtactgtggc cttcctccat gggggacttg cacttcctca aagccctgga tttctgtgca 24900 gaagagcagt tttagttctt ccttaggcac ttccctttcc tcctgtccag tgtcatgttc 24960 ttgtttgtta tgggctccac ccagacgatt atttcctctt agatgatgtg tgagccttgc 25020 agagagctgg gtcatttgtg gaataaatca tgtgcccagt cacacggctc cttacaggaa 25080 atggttggtg catattagct tagcacaaaa tacagtagtg agcttgtggt ccccaacagt 25140 gagtcttcag ttaacttctg ctgttttttt tttttttttt ttaacataaa gctttgaatg 25200 tttcatacag tatcaaatct ctgcaggatt ttgcctgctg aaacagatgt gaaaatctga 25260 gtagcacaga gtatgacatt aaggccataa caataaacct attgttgctg cattctaaat 25320 ttgatcaaga tgtctgtttt tgggaatcca aaatagttgc ttcaaattta gcttttttct 25380 tttatgaagc agttttgttt tgttttgttt tgagacctct catagcaaga aaaaacatta 25440 cataaacttt tttttgagac aaggtctcac tttgttaccc aggctggagt gcagtggcac 25500 gatcttggct cactgcagcc tcgacctcct gggctcaagc agtcctccca ccttagtccc 25560 ccacgtagct gggactacag gcacatgcca ccacgcccgg ctaatttttg tatttttagt 25620 agagacaggg tttcaccatg ttgcccaggc tggtctcgaa ctcctgagca caagcgatct 25680 gccgcctg gcctcccaaa gtgctaagat tataggcgtg agccaccatg cctggccaca 25740 taaatataaa cttaaaaata cacaggaaaa cctttcagaa cactttgaaa cctattttgg 25800 tcctattacg attgcactga atgtccccca gcctaatgaa gagcaattag atgtcatttg 25860 gtggcattct tggtggagac agtaagctag ggccgcagga gctgcttagt ctcccagggt 25920 ccagcattgt ttcaggtaac gtgaacagga tgctcaagag ctagtctaaa taatgcttca 25980 tgtcttattt ttcctgtttg ttgataagga ttcataaaga tgtctttttc tggtcatgtc 26040 aagggaaatt caaataaaaa acattgaatt ggtttggagc tgtccattga agggtactca 26100 cagcaggaat tgagtggcaa ttgaatgtgt gtgtgtgtat gtttgtaaac atttatatta 26160 gagtgtatgc aaatgtatat gggcgtgccc actgccatca ccattacccc caccaacagt 26220 aacaaaacca ccatcaagag caatatccac taaaacttct aatttgctta ttaatttgct 26280 ttattattg taaatattc agaatctctg agatcaaat ccttttt tacaacatgt 26340 taatagtagt ctattcaga cctgccctga ggaagaacca agcaatgaag ctgtccatga 26400 ttttagaagt taattggctc attctttctg accatctagg tagtcccac attattg 26460 gctccccta gttaggtcca caactcatt atttaccatt gggctggact ttggtctcgc 26520 ttatacagca agtagtagag cctacactg tcacatgta aacatttgca tattttacat 26580 ttatagagag atactttca cgtgcctcat ttgatccact aacatctgta tgcttgggta 26640 ggatggaata atttaacaat gtatagctaa agccatccaa acccctcaa tattatcatc 26700 tgatgggaag gaaaaggggg ggaaaggaaa ttaatagtt atttcaatc ttggcatgat 26760 tgacactgac aattataaat tccattcaat atttttcc agctcatgag ggttggttgt 26820 aaggatactt tgcaagtcag atttatgagc agagatgtt tgcaaccta attgcttcag 26880 ttgcatgaaa aagtcacaac cttttactga ttttactcct gggatctcct taacaagaaa 26940 aaacctcagg cccaggaagt ctagggtgag gcagggatgt gtcaaagtac acttttcccc 27000 acgtacaggg acaagtattt gagtttcttt gattgacttt gcaaagagct ttgcacactt 27060 tgcacatcac ttcttgagat gggtgggaac atggactgcc tattttacag agttcaatta 27120 agatcgcagg atcatgcatt cctttcattt ttggtgctag tacctagaag atgggaacat 27180 attgaacact taataccttg cttgggcaga tagctccagt ttgcagaaag tctagacagg 27240 ataccctgct atgtatctag atttactgag aagaagcggc ccaagctaat cagaatttta 27300 aagtaggttt ctcagctggg cgtggtggct cacacctgta atcccagcac tttgggaggc 27360 cgaggcaggc agatcacttg aggtcagggg ttcgagacca gcctggccaa catggcgaaa 27420 tcctgtctct actaaaaata gaaaaattag ccgggcatgg tggcacgcac ctgtaatccc 27480 agctattcag gaggctgagg tgagagaact gcttgaaccc tggaggcgga agttgcagtg 27540 agctgagatt gtgccactgc actccagcct gggcgacaga gcgagactcc gtctcaaaaa 27600 aaaataaaat aaagtaggtt tctctatacc tttgaatttt ctgtctccca tgataacctt 27660 tgggtaaaca tgtccatcag aatggaaaca atcatttt taaaatagaa attackctca 27720 tacctatttt agtgggaatc cccctgagaa gatagccatg tatagtcgac tgaatgctct 27780 gtggttgcta tttgttgct cttggccagg aactgatct aggtgaccta cagacttaat 27840 ctgacctgca gactggccgc ttcatactac caattcca aagccaagtg tatatacagt 27900 cggcccatgc agcctctggt tccatgatgc aaccaatggc agattggttc aaaaatattt 27960 ggaaaaaggc caagcacagt ggagtggttc atgcctgtaa tcctagcact tgggaagct 28020 gaggcaggaa atcaatgga gcccgggaat tcagaccag cctgggcaa atggcaagc 28080 gccatctcta caaaagtaa ttagctgggc ttgtggcat gtgcctgtag tcccagctac 28140 ttgggaggct gaggtgggag gatcacttga gcccaggtga aggctgcagt gagccatgat 28200 tgcatcacca cactccagcc tgggtgacag agtgagaccc tatctcaaa tgagtaata 28260 aaataaaa ttcaaagg aaaaaagtgg aaaaaaaacc cgaaaaaata acaatacaca 28320 cataaataac agtataac ctatttacac agcatttaca ctttactagg tattgtaagt aatccaggga tgagttaaag tataaagg gatatgcata ggttatttgc agcaaatgcc atgccatttt father aggctcatgg ctaataagc atgaacccga ctgaagctgc ctgggtatgt gtctttgttc agccactttc tggtagtatc ttttttctta acctcagtat 28560 tcttatactg fathercagga atgttttctc tgtataggc tgttttgagg aatagtttct 28680. cccttaatag atactggctt 28680. cccttaatag atactggctt aaagataatt aggtatgtcc tagtgaggta tacctaacta caagtgctac tttaactatg cctactttgt gtgctttaca atatatattg ttcaaggcta gaatatgag ccccatgagc agggtttcat agcatttaag attccaacgc caaccttcaa tcatggacac aggtggcctg tgccatctag ctagctgcgc tgcctccagg ctgggtggcc tgctcctctg ttggataaaa 28920 atagcctgac tcctcactga aacaaccacc atgttatttg cgtccttggg aagctgaaag father ctaagtctgg cgttgccagc tgtcagcaga atgaaatgca aagtgtgacg tgtctacact gtacccactg gccttcaagt cccaactccc gttcccccat cttgattttt 29100 ttccattctc aaattaatta tttcccctat aggtgatttg tggaatggaa acagatttag 29160 atttcctacc tatttagatt tttccaaaga ctaaaattac aaatcagaaa aactgctatt 29220 gacacatttt tggttaggaa aatctggatg tggttcctat gcctagccta gtcatataaa 29280 ttctctcccc atgtatcttt ttgtgtgtgt gaaacagggt cttgtcaccc aagctggagt 29340 gcagtggtac aatcacagct caccatggcc ttgacttcct gggctcaagc aatcctctca 29400 cttcagtctc cctaatagtt gggactacag gctcgtatca ccacgtgcaa ctaatttgtt 29460 ttgatttgg gtagaaacag gtgtcactat ggtgcccagg ctagtaactc ctgtgctcca 29520 gcaatcctcc tgccttggcc tcccaaactc ctgggattac aggcctgagt caccaagctc 29580 agcctctcct catcaaaacc attccctctt tgtaagattc ttcctatgtc ttaaaactta 29640 ataccttaa tccttccctg gagccatagt tttatttatt tatttattta tttatgagac 29700 agggtctcac tttgttgccc gggctggagt gcagtgacac gatcatagct cactgctgcc 29760 atgacctcct ggactgaagt gatcctccta cctcagcctc ctgagtagct gggaccacag 29820 gtgtgcgcca ccacaccagt tgttgttgtt gttgtttgtt tttgttttgg tagaaacagg 29880 gtctctccat gttgcccagg ctggtcgcga actcctgggc tcaagcaatc cacctgcctc 29940 agcctcccaa agtgctgggc ttgtaggcgt gagccaccgc acctgtccct gtctgctttt 30000 attttttt tttttgagat ggagtcttgc tctgttgccc aggctggagt gcagtggtgc 30060 gatctcagct gactgcaacc tctgcctccc aggttcaagc cgattctcct gcctcagcct 30120 cctgagtagc tgggattaca ggcacgtacc accacacccg gctgattttt gtatttttag 30180 tagagacgtg gtttcaccat gttggccagg ctgatctcga actccagacc tcaggtgatc 30240 cacccacctt ggcctcccaa agtgctggga ttacaggcat ataggtaagc cacagagata 30300 agatagcaa gcagtgatgg ggagaagata atctagtgta ggaaagatgg aaagaatggt 30360 gatattcac aactgctaga ttgacacttt aacttgagag ttatccctct ataaactgga 30420 tatttgctga gcaaagttta aagaaaactc catgtattca gtaatgtttt ccagacccca 30480 cttctcttat ataagccagt ggcttagagt gcttgctcta atttctatat tccattaaac 30540 aagggtggga tttcttctca ttcaaaccat ttgtgacttt gccctttagt gacctctacc 30600 atcaccctat cattaatgat ccaagtgatt agaatggatg gctatgtgtt tgtaggttgt 30660 30720 gatctgtgtt ctcatttaga ttgtatttgt aatctcccca cttcccacca tcaacagtgg 30780 cataatgtga attaatttat gtggtatctg tcatttaaaa aacatgagct ctctccttcc 30840 tttttttgtc ttaaatag gacatggatt tgattgacat actttggagg caagatatag 30900 atcttggagt aagtcgagaa gtatttgact tcagtcagcg acggaaagag tatgagctgg 30960 aaaaacagaa aaaacttgaa aaggaagac aagacaact ccaaaaggag caagagaaag 31020 cctttttcgc tcagttacaa ctagatgaag agacaggtga attctccca attcagccag 31080 cccagcacat ccagtcagaa accagtggat ctgccaacta ctcccaggta cagagtactc 31140 agttcttggg aaagttatgg caggtttaag gaaacactga gcaaggaatt aaaatatctg 31200 gatttgagtt ccagctttgc cttctttta cttaaccttg tcaaatctac tttccaacct 31260 cagcctcctg atgagttcag tacctaacct gagttcagta cccaacctat tgatcttaac 31320 agtgttattg tgaggattgg gaagacttaa gttacaccaa agagttttgt aaagtataga 31380 aacatcctgt aaggatcaag tagcagcaac agaagtagta gcaggagaac caagtagcag 31440 ggattactgg cgttactgtg tgtggcaagc actgttttaa gaacatatac tgactgattt 31500 attaacaca actatattaa ttagttacca ttatccctgt tttatctacg atgagcaact 31560 gaagctcaca aaggttaaat aatttgccca gatcactcag aaaattggag gagctaagat 31620 ctgaacccat gtggtctagt tcaaattgtg catcaaagtg atctctgaaa taagataaat 31680 attacttaa cttgattata aatattttat gaacatcaat tattgaatat ttagcttggc 31740 aatggaatat ttaaccattt ttgttttcct ttgtgtcatt cccttttatc aggttgccca 31800 cattcccaaa tcagatgctt tgtactttga tgactgcatg cagctttgg cgcagacatt 31860 cccgtttgta gatgacaatg aggtgaggta taaatacc tggttaatag aaaaactcca 31920 tcataactat aaataaca tctattctat gtaagtcccg tcaatgaatc tccatttaaa 31980 agataaaaa cattttagg aggaattttt tcaaccaagg aatactct gtcaaggaaa 32040 ccttagccta taaatactt aaaaaaaaa acccttcaca caatacaaaa 32100 ccaaaaccat tgactattgc atagccagaa acatggacag cataaccatg gaaacaata 32160 accattgc tgcaagtatc taagaggttt ggtgagtaaa gagccagctg ggcaataac 32220 gaagacttgt tcagttaaca attttaataa atctgtttta tctagtacca ctgtgctaga 32280 tattatataa actaaatcct aaagattgta cttacgcatt ttaaagttta ctttcaaatg 32340 cttaagctga aacagaccag caattataa atttgagtca gtggggtagg aaaaaagat 32400 ttgttattta caaacggggt catgactggt tagtagtag agagacacag aactgcagct 32460 gattccattt tgttttgtag tggtgcctta gagcttactc atcccctgtt ggtggaagac 32520 tcataaatca atgccttatc aattttaggt ttcttcggct acgtttcagt cacttgttcc 32580 tgatattccc ggtcacatcg agagcccagt cttcattgct actaatcagg ctcagtcacc 32640 tgaaacttct gttgctcagg tagcccctgt tgatttagac ggtatgcaac aggacattga 32700 gcaagtttgg gaggagctat tatccattcc tgagttacag gtaactaaaa tagaatgtaa 32760 tactggagat ttttttatta ttcagtgcct ttagtcattc tgattattta tataccacct 32820 attatagga aggattggag ggtgctatta acttagtcat gagtactgcc catgctagtt 32880 aaattggttg gacatcttga ggatagaatg ttataaacct gacgtctgat ctgggaactc 32940 tgaaaataat acataacgct taggcgtaaa tatgtattgg aaatgagaat tatctctgaa 33000 ttatagataa taaattatag agataagcct gaagataatg tgggtaggga gtttatctaa 33060 attatcacg tattatcatg gattaacttt gatttatata gtataaactt ccttctcatg 33120 cagtgtctta atattgaaaa tgacaagctg gttgagacta ccatggttcc aagtccagaa 33180 gccaaactga cagaagttga caattatcat ttttactcat ctataccctc aatggaaaaa 33240 gaagtaggta actgtagtcc acattttctt aatgcttttg aggattcctt cagcagcatc 33300 ctctccacag aagaccccaa ccagttgaca gtgaactcat taaattcaga tgccacagtc 33360 aacacagatt ttggtgatga attttattct gctttcatag ctgagcccag tatcagcaac 33420 agcatgccct cacctgctac tttaagccat tcactctctg aacttctaaa tgggcccatt 33480 gatgtttg atctatcact ttgcaaagct ttcaaccaaa accaccctga aagcacagca 33540 gaattcaatg attctgactc cggcatttca ctaaacacaa gtcccagtgt ggcatcacca 33600 gaacactcag tggaatcttc cagctatgga gacacactac ttggcctcag tgattctgaa 33660 gtggaagagc tagatagtgc ccctggaagt gtcaaacaga atggtcctaa aacaccagta 33720 cattcttctg gggatatggt acaacccttg tcaccatctc aggggcagag cactcacgtg 33780 catgatgcc aatgtgagaa cacaccagag aaagaattgc ctgtaagtcc tggtcatcgg 33840 aaaacccat tcaaaaga caacattca agccgcttgg aggctcatct cacaagagat 33900 gaacttagggg caaagctct ccatatccca ttccctgtag aaaaaatcat taacctccct 33960 gttgttgact tcaacgaaat gatgtccaaa gagcagttca atgaagctca acttgcatta 34020 attcgggata tacgtaggag gggtaagaat aaagtggctg ctcagaattg cagaaaaaga 34080 aactgaaa atatagtaga actagagca gatttagatc atttgaaaga tgaaaaagaa 34140 aaattgctca aagaaaaagg agaaatgac aaagccttc acctactgaa aaaacaactc 34200 agcaccttat atctcgaagt ttcagcatg ctacgtgatg aagatggaaa accttattct 34260 cctagtgaat actccctgca gcaacaaga gatggcaatg ttttccttgt tcccaaagt 34320 aagaagccag atgttaagaa aaactagat taggatt tgaccttttc tgagctagtt 34380 tttttgtact attatactaa aagctcctac tgtgatgtga aatgctcata ctttataagt 34440 aattctatgc aaatcatag ccaaactag tatagaaat atacgaac tttaaaagc 34500 attggagtgt cagtatgttg atcagtagt ttcactttaa ctgtaaacaa tttcttagga 34560 caccatttgg gctagtttct gtgtaagtgt aaatactaca aaaacttatt tatactgttc 34620 ttatgtcatt tgttatattc atagatttat atgatgatat gacatctggc taaaaagaaa 34680 ttattgcaaa actaaccact atgtactttt ttataaatac tgtatggaca aaaaatggca 34740 ttttttatat taaattgttt agctctggca aaaaaaaaaa attttaagag ctggtactaa 34800 taaaggatta ttatgactgt taaattatt 34829 <210> 4 <211> 30584 <212> DNA <213> Homo sapiens <400> 4 ctctgctctg gacttgggag gctccgttgc ctgctcccgg agggagacgc gctgccgagg 60 agaacccagc gggtaatgaa tcccccgcgc ttctttgccc aggccttccc caaacctccc 120 cccggtctgc gcgggttctc ctattgggct gtggtgaaga caaggtgcgg cgactgcagc 180 tccccaggtc tgggcgctgc cgggagagag tctttcccgc tggggagatt tagtttgttg 240 actcaggagc acctccaacg acagctagtg gcagaggacc cgggagctgg gaggttcgga 300 acgcggggcg agctggggag gagggagagg cgccgaccca gcgcagccta catcttagca 360 aaccaaacct ggcaacattt ccccacggtt caggagcacg aggacttaa gggaaaacga 420 cgaaatcggg gctcccgagg atgaagttaa atgggttgtg gcctggggac aaatagggcc 480 aatgtccagt ctattacaag aggctttgtt ccagaggctt gcctataagc ccctggcttg 540 gaacgtcagt cttcaaactg taacaacagg ggcaggctac tagggtagcc cacaaagccc 600 tgtatcccc atacagtgac taactagagc cctagttggt catatccgca gtggctgaga 660 ctgcggtgtg attccgtttc cctcttgcat gtgtcccggg agcccgagtt gtcgaagccc 720 aaattcaggc tcaggaacct gatgtgctgt tgatgccaaa cactgacaca cagatgcttg 780 gagacagagg aagatttat ccatttggcc aaagcgagaa ggcaagaggt caagatctct 840 caaatccacc ctaacaaaaa gaagtagtgg ggagttttta tgagaccagg aagtaaggga 900 gggggaattt cagggaacct cgggggaaaag tctttcttcg tctcagatta catcttgaac 960 caccagactt ctgggcgtca gcagctggtc acaatgccct taaaggcatt cattccttct 1020 gcaaaatttt tttcttgact ctgaagctat atcctcctgc ttgacaaaga aacggtgcat 1080 cagcagttta taattatatt gctagaaaaa ggaatattgg gcaaaaagtg ggtagttaac 1140 atatgcaaat aagcaagggc ctcatcggaa ttttcatggt ttcatcacta aaaatgttgg 1200 ggtgctgaaa tcttgagggg ctcggttgca ccagaagggg atcctttgtc actagtgcag 1260 gcaggaaggg atgcttgagg gaggatgggg ggaacttttc aatagttcct cccctcccct 1320 accaatagcg ggtgggaggg cgttggttta gagccaagcc tctaggagaa gatgagagca 1380 atggctaaag tttgtctggc ctcgccctat gagaaggggg cggaggctgt gcctgccttt 1440 gtgggggaaa aagaagccga ttcctaatct gtctgtctca tgggaggtga gagttcctgt 1500 ggcaggataa cagacaagca attcagtgtg ataacatcct gtgtcagaag tattcattta 1560 aatgtcacaa gaggccgggc gccgtggctt atgcctgtaa tctcagcact ttgggaggct 1620 gaggctggtg gatcacgtga ggtgggcgga tcacttgagg tcaggagttc gagacagcct 1680 ggccaacatg gtgaaacccc atctgtacaa aaaatgcaaa aattagctgg atgtgatgac 1740 acatgcctgt aattccagct actcggagcc tgaggcagga gaattgcttg aaccaccccc 1800 tccccccacc aaaaaaag tcacagaat taaactctt tgtttaagaat ataagcagt 1860 ttttattt ccatgtaaga ggaagagag gaaatgctg tgatccactc ctggcctgat 1920 tatgaaaatt cacacgtgtt tatagcagcc ccactttaac catgggat gtcccagac 1980 cctaagttga tgcctaaaac cagatgcctg aaaccatggg tagcaccaaa ccctatatct 2040 aatgtgtttt ttccctatac ttcactgtt tcacttaag aaagcactta aagaaaggct 2100 tttctttggc atatctgaat tgccagcatc actactctgg agatttgggg ccattaaata 2160 aaatagagt tacttgaca taagcagtat tagttgat ctggtaagta agaaggctac 2220 caagtgacta agggctagta gcatatacgg ggtgagtaca ccagacaag gatgatca 2280 tgtcctgggg tgagaggg tggatggcat gagatttcat caggctactc agaatgaaac 2340 ttgaaactta taaattattt atttctggaa tttcattt atattttg gactagagct 2400 gactgtgta actaaagcat ggaaaaccac cagataaggg aggacta tatactatca 2460 gaaaatagaa atcattcca gtattattgt tatggcaat tgaatcatat gatatacact 2520 cttttatgtc tggcttctgt cactcagcat cattgttttc agattcatct atgtcattgt 2580 gggtaccaat agttctttcc tttttattac ggttgagtag tcttctatta tatggataat 2640 caatattggc ttcttcattc atctactgat gggcatttgg attgtttcca gtctatgtct 2700 ttcacaaata aaaatgttat gaacattcat gcacaagtct ttgtatggac atatgctttt 2760 tttttttttt cctcttgggt aaatactttg gtgtggaatg gctgggtcat atggcaagcg 2820 tacgcagaac ttcttaagaa actgccaaat tcttttccaa aatggtcgta cccctttata 2880 tccctacaag gagtatatga cgatgcccat tccttcacat cttcaccaac aactagcatg 2940 gttagtcatt ttagccattc taatagatgt gtagtggtat ctcactgaag ttttaatagg 3000 catttcccta acgactaatg atgttgagca taattcaatg tgcttatttg tatccatata 3060 ttttctttgg taaattgtct attcaagtat tttattcatt tttaaattgg gtttttttat 3120 cattactttt tgagtgttct atatataatc tacttacaag ttctttatca gttatgtaat 3180 ttgcaaatac cttcttccag tcagaggttt atattttctt tttttcttaa acttttactt 3240 taagttcagg agtacttgtg cctgacgtgc aggtttgtta catagataaa tgtgttgcca 3300 tggtggtttg ctgcacagat catcccatca cctaggtatt aagcccagca gccattagca 3360 ccattctgat gctctcgctc ctcctgttgc cccctcctct gacaggctgg ggcttatatt 3420 ttcattctct taatagtgtc tttcagaagg agaagttctt aaagtccaat atatcattta 3480 aaaaaattta ttgtgcatct aggccaggtg cagtggctca tgcctgtaaa cccagcactt 3540 tgggaggccg aggcagggag atcacttgag gtcaggagtt tgagaccagc ctggtcaaca 3600 tggtgaaatg ccatctctac taaaattaca aaatttaccc aggcgtggtg gtgggcacct 3660 gtaatcccag ctactagaga ggctgaggca ggagaatcgc ttgaacccaa ggggtggagg 3720 ttccagtgac cgaaatagca ccactgcact ccagcctggg cagcagaggg agactccatc 3780 tcagaaaaaa aaaaaaaaat tattttgttc atctaatatc atctgtaaga aatgtttgcc 3840 taacccaagg caaaaatatt ttctcttata tttttctcta gaaattttat ggttgacagg 3900 ctaaatatac atacaaactc tggccaggac atatgcaaaa atagaactct gacccagaac 3960 tgctgcagta accagcctgg gaagccaaac acaacttctg cagcagttga ctggtagtgg 4020 tcaggacctt gtcaataact gacagcatcc ttaatttttg ctcctgattc caatttagga 4080 ccagtcagag aaagccaaat atgttcccca aactaatcat acaggatgtt catttctagt 4140 tagcctgctt ccaacttccc tacgacaaca cccttgaatc atatcatacc tgagcattcc 4200 ctttttgtca ctatcaatct ttcccctgcc tgtctatgag gctttgacaa atgtgagtga 4260 tgatggcggc tgactccctc gttatagtga gctctgaata aacagcctct gcttgttctc 4320 atccaggcag acttcattaa tgtctttagt ttccttgcag gttccaccaa ggtaccatct 4380 gcccactgtg tggactccca ttttcaaaca ggatggctgc tacagaggca ccttgcacct 4440 tgcagagagt ggtttgttga gtttgcactg ataggataag tcagcactga ctgaatgtct 4500 cttttttttg agttcctcag ctactgattc tcatttgata cccgggtttt gttattggtt 4560 cccatttatt tggcacccta ggtggaatca ggccattctc tttcacctct tttggctctc 4620 ttttttgtgt gtttgtgttg tgctgtttaa aagcggtttg tccgaagaag gagaatgaca 4680 gggtcagaca taggcatagg tcctacaagc ctgttcaagc ttgcttcaca gtccagtgag tttgtggttc tccctgaacc catgtccatg tggacaaact ttgttgtggg tcaccaata 4860. aaccagctca ggttctcctt ccatcttgcg tttttgtcct gagagcttca ctttggtcca cggggagtgc tttctctggt tttctgccta ctgaggggca cagattgtct ggtctgtgtt 4920 aggaggtgcc caactgtacg gttggggacc tgagacacaa agtgcacaag aattatactc ctactgatgg tcaacagctc tcatggggtc ttctaagtct aaataccctc ctcatctagg 5040 agaaactgct tcttatttgt acaacactag ctcatgcacc taccttccta ccttcctaat ggcataactc caaggatgat ctgggccttt actggctatt ttggggtaca tttgacttga acaaattgt tcatttgaca tgcaccttag aaaagtagga ataagatttc tcaggatgaa tggggctgcc gttttttgtt ggtaggcaga ggcctccaaa tgaattctg atcaaaaatt gcttcattaa aagattcttt gcccaaaacc aatgggaaat ttgacacact taacaacaa caaactagac tcatttccct agtaaatgct tctttttctt gtcttccaga tgcctccgtg tatccagctc tctcttttcc cccttatcct tctattaggt tggtgcaaga gtaattgcaa 5460 tttttgccat gactttcaat aatctctctc ctatacttca gtcaactgct cactttctt 5520 cccccttttc agacccccac cctttgccca ataactctcc taaactccaa aattccagtt 5580 gcctctgaat atccatccct ctctttaagc caggtatgca gacatctgta gaatttaaac 5640 cttggatcca agctgaatta agagttatac ttaaaggttt ccctaaaccc agcaagacta 5700 gcaaaaattc acaaaagaat ttagaattct tctaggtaca tatgacccaa ggttacctaa 5760 cctctatcaa cttgtacaca tgttggtcag aatctcaggt gctaaatcct ggagggcaaa 5820 agctgattgg agactcag aaagggaccc aagtatccc tctttccata gtaaatccga 5880 gggttttaaa aaaaaggatc caaaaagtaa ggcaaagtct cctaaaagcc atacccaaat 5940 catttctaat aaaaatccat tggaccatgc aaacaaaaaa ataaactgt tggactttt 6000 caggatagac taggaaatac cttccaacac atcagttaaa gaaggtggta aaaagcagcc 6060 ctttcatctc attttgtcag tggagttaaa catgaaattg gagacttaat tctaaaacag 6120 aaattggaat ggaaacaac ccctttatct gattgtaac accaagcaga acatttgaa 6180 agagctttag aactaaatg agacaggact caaataac tgtggccca cttcccaatc 6240 aaccacctat tgacaaggac actacagata tgtaaacag aaccaagaca aaaaaatc 6300 catcagttca gatcaatgag ggtgctcaga ggaggagaa actacccaat agtctgcctt 6360 tccctaaaca ctcaggtga tttaactata atacaggtg gtcaacttca tcaatttctg 6420 gtaaacatgg tactactct tctatgttaa acactgccc tttgctca tctctctc 6480 tgagtaaaca taccacag gtggtaggta ttcaagtaa cccacatata agccacatat 6540 ttattccatc tcccagccct taactgtagc ccttggtccc tgactgaaaa acatccttc 6600 ctcctctttg atatcatgcc tatgagttta atgagactt atttgcaa tggaactgta 6660 atatgtattg atgttccaga gactctcta ttcataatca agttgcacct gctatgaata 6720 cacctttgct ttctctatta tatttgatgc atactccaaa taataatctt gataccaac 6780 ctgacagtgt aaggggctaa aaattccact cacataggac gaataattgg agaagcaaaa 6840 taatagcag aacttacta gttcagacag atcctgtcaa accattaccc aaacttcccc 6900 atatccata gaagtcagac gcaaggaat ggctcgaacc tacagttgaa ggccttatat 6960 gcaaggtcc tctcctatcc cctagtaaca ctcctgtccc gccagcaag aaaccaagtg 7020 gatgagata ttgatttaag acttcagaac catcacaa attgtcattt cttttttccc 7080 agtagtgcct aaccacaca ccatctgtca ttattac tgaagtcac tgctttact 7140 gtagtagaaa ttttctctgc cttttcagt gcacctttag acaagacag tcaatacttt 7200 tctgcctttg ccttgggaag gatagta taactggaca gtcatactcc agagattcat 7260 tgaagcccct gttttgtcc agatgctcaa gtaagagtta aagatggct gggcgcggtg 7320 gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcggatcac gaggtcagat 7380 caaccaccatc ctggctaaaa cggtgaaacc cggtctctac taaaaaaaaa tatcaaaat 7440 tagccaggcg tggtggcggg cgcctgt cccagctact cgggaggctg aggcaggaga 7500 atggcgtgaa cccgggaggc ggagcttgca gtgagccgag gtcgcgccac tgcactccag 7560 cctgggcgac agagcaagac tcatctcaaa aaaaaaaaaa aagagttaaa agacataaat 7620 ttcccttgtg accttgtgat tcagttctga tacaatataa aaatgatctc ctactttgtt 7680 cagagaacaa ggaagcctgt taaaaggatt ccattttctt gctctcagcc ttagtagaga 7740 agggacataa aatttttaag gctaaattac aattttacca aaacacaatt cattatttga 7800 agtaaacctc tctaaggagg gataaatatt ctctcctgat aaagattatc cgaagttatt 7860 gtaaatccct cacaaaatga cagatgagag gatttctagg ttaactggat attgcaaaca 7920 ataggtgcca aagttttctg aaattggagc acctctttat ggattgactg tcttcagtga 7980 gggattctct cctttgaaag tccaaacata aagacctcct ggaacctgaa atcagttctt 8040 caacagcctc cttcccaaag caccccaact gtagaaagcc attttgtcta tttgtgcgag 8100 agcgatgtag agaagccctt gggccttcaa cttcatggaa accatgaaaa ccccattatt 8160 tgctgtagcc tcactcttga cctgtttaaa aggcttattt ctattggttt agggcattag 8220 ctgtcactgc aaaacttgat gatgcttctg ccaaactagc tctaggctca ttccccgcct 8280 gacctcatgg tttctcatgc aacacaaaca ttactaattt ggggtttttt tttgtttgtt 8340 tttttgtttt ttgagacgga gtctcgctct gtcacccagg ctggagtgca gtggcgcgat 8400 ctcggctcac tgcaagctcc gcctcccggg ttcacgccat tctcctgcct caacctcccg 8460 agtagctggg actacaggca cccgccacca cgccaggtta attttttgta tttttagtag 8520 agacggggtt tcaccgtgtt agccaggatg gtctcaatct ctgacctcgt gatctgccag 8580 cctcggcctc ccaaagtgct gggattacag gcatgagcca tggcgcccgg actttttttt 8640 tttttttttt ttttttttta aagacagagt cttgttctgt cgcccacgct ggagtgcaat 8700 ggcatgattt cggctcactg caacttctgc ctcctaggtt caagcgattc tcctgcctca 8760 acctcccgag tagctgggat tacaggcaca caccaccacg ccctgctaat ttttgtaatt 8820 ttagtagaaa cagggtttca ccatgttggc caggctggtc tcaaactcct gcccccaggt 8880 gatccaccca tgaaaaaatc tggttgaatc tttactctca taatctctgg tgctctcaaa 8940 atggccactt gctggcacca aattatttaa aatggatatt agctaaattt ctccatgaaa 9000 ttactcatta tatatagac aaattggtca ctatcttaaa tccacatccg tgggaaaact 9060 aaaaagacag ctgagcggtg gggcatggtg gctcatacct gtaatcccag cactttaaga 9120 ggctgaggca ggaggattgc ttgaggttat gagtttgaga ccagcctagg caatcttgta 9180 agaccctatc tgtacaaaaa attaaaaaa ttagctgtgc attgtggcgc gttcttgtag 9240 tcctagctac ttgggaggct aaggcaggag gatagcttga gcctaagagt tcaaggctat 9300 agtgagccat gactgcactc cagcctgggt gacagagtga aaagccctgt ctctaaaaaa 9360 acaaaaacca aaaaggacag ctgaggatat tttcaggtta tgtgtcgcct gtcaacaaca 9420 taatcctgga aaaattctaa tgtcatcttt tgttcctcta tagataatgt gcctttttcc 9480 tctggatgct tttaagattt ttttctgtat cactggtttt gaacaattta attatgatgt 9540 tcctcagtat ttttttttt cacatttctt gtgcttaagg tttgtgtaac atcttagatt 9600 ttagatcttg atttttcta gtgttcatca aatttctttc aaaaatgttt tagttgtttc 9660 agacaggaga gtagcctagt ccctagtact ttattctgac tggaagtgaa agtctcatga 9720 atgtagtttt gaaaatcata gttccttaga cacagtaagg aaaccaatgg cctcagcctc 9780 tcccacttct gcttgccagg agcctcttgt ctctcgggct ttttcttctg gcacgtgttt 9840 ctgtatttct aaacagcatg cttattttct cctttctccc tcccaccccc tctcatttta 9900 gatattgtct tagtcaattt gggctgctgt aacaaaatac catggactgg gtggctttta 9960 aacaacaaaa atttattgca cacaattttg gtggctggga agtccaaggt gctgagagat 10020 ttggtatctg gagagggccc tcatagatgg tgccttctca ctgggtcctc gcatggtagc 10080 gggggtgtat atgctccctt ggacctcttt cataagggca ctaatctcac ttatgagggt 10140 acatcatcat gacctaatca ccttccaatg gccctatctc ctaataccag cacctttagg 10200 gttaggattt gcacaatgaa ctttagggag ttgcaaacat tcagaccata aaagatactg 10260 tttatttctg gaagatgact gtatagcact ctctctctct ctctctttta aatctttgga 10320 gacagggtct ccctctgttg cccaggctgg agtgcagtgg tatgatcttg gctcactgca 10380 gcctcaatcc actgggctca ggagatcctc ctacctcagc ttcccaagta ggtaggacta 10440 caggtgcatg ccaccatgct tggtgttttg gtttttgaag agataagaac tcgttatccc 10500 attatgttgc ccaggctggt cttaagctcc tggcctcaag caatcctccc accttggcct 10560 cccaaaatgg gggaattaca ggtgtgagcc gctgtgcctg gcctgagtat agctaacagt 10620 tttttttttt tttttttttt ttttgagatg gagtctcact ctgtcaccca ggctggagtg 10680 cagtggcatg atctcagctc actgcaatct ccagctcctg ggctcaagtg attcttgtgc 10740 ctcagcctcc tgagtagctg agactacagc cgcatgccac cttgcctggc taatttttgt 10800 atttttcgta gagatgggat ttcactgtgt tggccaggct ggtcttgaac tcctaacctc 10860 aggtgatccg cccaccttgt cttcccaaag tgctgggatt acaagcatga gccactgtgc 10920 ctggccaaca cttcttatcc tatgccttcc ttctccacat cctgccaata caactatatc 10980 ttatatcatc attttttatc agaacaatat tcggagttta tattatcatg actaggactt 11040 tatttacaac ggtgccaaat aatgccttat ggttatcttt tatttactat actacttttt 11100 attttaactt agcattattg tcttatattt gtatttgtct gtcttcctaa gtgcctatga 11160 ccaattcatc ccctactctc caccctctca gtttactaag tgatctgtca attgcatggt 11220 cttaggctct gtccaccgaa gcctgctgct ctgttgtgca gttttgcctg tgatctgtag 11280 gcctgctctg cagctgttat tcccagacct cccttcacaa acatccaggg gatttttaaa 11340 cttcctttcc ttgttgaatc tcttgtttcc tgcatccact tttttgaggg aagaaatgca 11400 gggggcaggg caaagacagt gtccagagag catgaaatct gaaatctcag ttcacagtgc 11460 caactcttac gacacagggt tctgtaatca tgcatgagtc actgtttttc ttcctacttc 11520 agagaacttc aaattttgcc agcaatgccc agcatccatt actgcaggca ttctattttg 11580 gtgtcatcaa cttccctgct caagttttca gtgcacttgg cattccttct gcgtacatgt 11640 tgaggtttaa atttctggat ttcggccggg cgtggtggct cacgcctgta atcccagcaa 11700 tttgggaggc tgaagcgggt ggatcacctg aggtcaggag ttcgagacca gcctggctaa 11760 catggcgaaa ccctgtctct actaaaaata caaaaattag ctgggcatgg tggcttgtgc 11820 ctgtagtccc agctactcag aaggctgagg aaggagaatc acttgaaccc aggaggcaga 11880 ggttgcagtg agctgagatc acaccactgc actacagcct gggcaataga gcgaggctct 11940 gtctcaaaa aaatcaaata aaaaaa taaatttctg gattttaaa aactcactat 12000 tgtttttcaa taatcttga ggggtgaagg aggtacagac atctttctg ggattcttta 12060 gttagaatct cctgttattc ttctattag aaaaggatt atgatgtta aaaagacaa 12120 atcttattgt taatggctct gcaaccaac aacacaaaa tattagaga aaagtgctga 12180 aggaaatgca ttagaatgct aaatctttaa atggtgaatc tataagtgtt ctttttcttt 12240 aattctgcct ttggttttc tttcttgac acattgagca catacttttgctgg 12300 gaaaaatgta agttgaata aaaaacacat agaaaacact gatctgctt ttagaaatg 12360 actaccatga tatgtgtgtg tatgcgtgcg cacatgtgca tacgcatggg tgtttagcg 12420 gatctaatc taatctgtgt gtctctcaga gttgggaggt agagccttag ggctttaact 12480 agagatgaaa agacatacat ggaacaatgg atggagtcct gcagggaacc attgtctgcc 12540 tgagcagaaa gcttgtactt gtataacagt gcctgggaaa aaaaatgaaa actcatttca 12600 ttttgggata attttattgt aaagtatacc acacatacaa cagagaataa aactttatta 12660 catagttaaa aaaatattaa aataaacaca catgtattca ctccagatta agaaatacat 12720 ttctagaagc taagaagctt cctgtatatt tctcccctat ttctctgtct ccctaattcc 12780 acccttcc tccccaaaca gaggtagcca ctattttgaa tgttctatta tttccttact 12840 tttcttatg atattactac ctatatatgt ctccctaaat aacacattat ttagttttac 12900 ctgtttttga acttcatata aatggaatca tatagatgt attctgtggt ttgtgtattt 12960 tttacaacat tatattctta gagttcattc aaaatagtgc atgtaggctg ggcgcggtgg 13020 cttacgcctg taatgccagt atattgggag gccaaggcgg gcagatcacc ggaggtcagg 13080 agttcaagac cagcctggca aacatggtga aaccctgtct ctactaaaaa tacaaaaatt 13140 agccgggaat ggtggcaggc acctgtagtc ccagatcctc gggaggctga ggcaggagaa 13200 13260. tcgcttgac ctgggaggca gagtttacac tgagccgaga tcacaccact gcactccagc ctgggcaaca agaagtagac tccatctcaa aaaacaaaac aaaatagtgc atgtaatagt gaaagtggat gtcattttcc attack tgactttatt actgtgtatt tccaattttt tgctattttg aacagcaatc ctttgaaaat tcttgttcat ctctccagga tatctgcttt ttttttctg ttttaatctc acaaaacact accagttttgg ttctttttaca cctgttttcag agtatgca agtagttaa aacaatttc ctaaagacac aaagctggca aatactggga gtttgaactc agggtttcct cattccacag cccaagtgat ttactattac acgatgccac cttcctttta gtgattgcct tgtggcacag ctgcatgaaa ttgtggatac tgaggtcaat 13680 caggtcataa aaagcctctt ttgatctgat ttcatgctta tcaagcagcc ttctgaaatc tggcttcaca tactctacac caggggtccc cctggccctg gaccagtacc tgactgtggc ctgttagga ccaggctgaa cagcaggagg tgagtgtaag tgagcattac cgcctgagct ttgcctcctg tcgtatcagc ggtggcatta gattctcata ggaacatgaa ccctattgtg 13920 aactgtgcat gtgagggatc taggctgcgc actccttatg agaatctaac taatgcctgg 13980 tgatctgagg tagaacagtg ccatcctgaa accatctcct caccaacccc caacccccat 14040 ccgtgaaaaa attgtcttcc aagaaactga tcctggggac cactgctcta aatctacagg 14100 aaggaatgag atgctttgaa ataaacacct gagctccccc atattacat ttcccactga 14160 acagtaatca agtatcactg tgactcagct atttctgttt tgagtttggg gtacgaaatc 14220 accttccctc agaagggaac tttggggtcc taaaaagatt aattttatgg tcctgacatg 14280 tcgaagacta ggtcttagat acaattaatt tcaccaagga cctgccattc cagtggcaat 14340 tcttggcagc cggacaggtg gcttttcctg gcaacacccc aacaaaaact tgagctcttt 14400 tgccaatgtt tacattgtgt actcatgatt tattatctac tggatctcag atcctttgtt 14460 cccgctggag taaagcaatt tttttttt tgcactagtg cttgatgtct tgtggagtta 14520 ctatggagca agctgaataa ctgcagcctg gtgctgagat gttgggctca gtcttgccta 14580 tgccccttgt cactgaaaat gcccctgctc acagaaacac agctaggatg tatatatatg 14640 attttttttt gacaagatgg aaaccgtttg gattaggggga agctgacgtc gttgctatgt 14700 atctgttcca tagcaacaat gacaggttgc caactcaatc agatgtgtcc cctcccaata 14760 ttaggctaca aaataatctg aaaattgccc aagtctcagg gaggagaa agacaaagaa 14820 tcaagaaaaa caataatat tagcacaccc cagagatact tctgaccacg aaagctttct 14880 cattgctttc cagctccagt ccacaaatat caatgtaaaa ttttctattt tctgcaggtg 14940 acctgcgaga ctctgccact ttgagaactt ggcagatagt tactaaatac acagcataaa 15000 tataacctgt tggtcatttc tgtggtggtg gtgtgcttcc agcagactca gctcctcaac 15060 tcaccttaca agcttaattc atgtataaat ctgacctcaa gctatgtggg aatttcattc 15120 atccattttc acactgctgt taaagacata cctgagacta atttataaag aaaaagaggt 15180 ttaatggact cacagttcca catggctggg gagtcctgac aatcacggtg gacggtgaaa 15240 ggcacgtctt acatggaggc agcaagta gaatgaag ccaagtgaa gggaaccc 15300 tttatgaaac catcagacct cgtgagactt attcactacc atgagaacaa atgggggaa 15360 actgcccccc atgactcaat tatctcccac cggcttccctc ctacacatg tgggaattat 15420 gggagctaca attcagatg agatttggggt ggggacacag tcaatcata tcaggaataa 15480 atgaagggac caactcagt aggatggcct taatctgttg gttttcctgc ctctcctatt 15540 cttgtcctgt tctaatggtt ctatctttct gttttcagg agaacatttc aggataggaa 15600 taggccaagt gctgagaga tgagtcttag gattgatgtg gatcaact ttcctgagtg 15660 tgttgtagat gcaggaaag tcacctgg gactcagcag aggcaggaga tggaccctcg 15720 cctgcgggag aaacagaatg aaatcatcct gcgagcagta tgtgctctgc tgaattctgg 15780 tggggcata atcaggctg agattgagaa aaggctac atcatgac gtcatggagt 15840 aggattggat gtgcctccaa ttttcagag ccatttagat aagatgcaga aggaaaacca 15900 ctttttgatt ttgtgaat catggacac agaggctggt gtgccacttg ctaccttatg 15960 ctccaatttg taccacagag agagaacatc caccgatgtc atggattctc aggaagctct ggcattcctc aaatgcagga ctcagactcc aacgaatatt aatgtttcca attcattagg tccacaggca gctcagggta gtgtacaata tgaaggtac ataaatgtgt cagctgctgc tttatttgat agaaagcggc ttcagtatct ggaaaaactc aaccttcctg agtccacaca tgttgaattt gtaatgttct cgacagacgt gtcacactgt gttaagaca gacttccgaa gtgtgtttct gcatttgcaa atactgaagg aggatatgta ttttttggtg tgcatgatga gacttgtcaa gtgattggat gtgaaaaaga gaaaatagac cttacgagct tgagggcttc tattgatggc tgtattaaga agctacctgt ccatcatttc tgcacacaga ggcctgagat aaatatgtc cttaacttcc ttgaagtgca tgataagggg gccctccgtg gatatgtctg 16560. tgcaatcaag gtggagaaat tctgctgtgc ggtgtttgcc aaagtgccta gttcctggca ggtgaaggac aaccgtgtga gacaattgcc cacaagaga tggactgctt ggatgatgga agctgaccca ggttagggag caatatccac aatggttgta atgtttgctg gcagcaaggc 16680 agggcgggtc agagaggaaa gagggatatg gtattccttg gaatctgggg aaagagattt 16740 actctctgat ttgcaattgt ctgacttatt aatccctgta gatgtagttc gtggattatt 16800 gcccttcctt tcttctgcca tcttaaatag tcttcattca acagatgccc tggctagtag 16860 ccccattaaa ggctggtgca gggggctgtt tgacctagtt atttcaattt tcacatcctt 16920 tcttatgttc atagtcaagc ctcttatttt tcaattatga gcttgcattt aattatttag 16980 gaaatttctt tttttcacat gtacagatgt gtccacttta atttactgcc actttcctct 17040 gactttccct tcttaaatat tcaccctttc tcactgccca cttccatttt ttgaaccaaa 17100 atatgaccaa atcacggctt tcgctctgct ttcccatttt tcctttgggg agccggtacg 17160 tgataagcca gaggatggtt ggtgacatgc atctatcctg gaaaaggaaa gcctgagata 17220 aaattagaca gagaaaacca atagtaactt cttcaaaggt ccagaaaaaa caaagtccac 17280 ctcagaatct gctcaggtgt ctatatccat tggcctttgc atcttctcat catttttctt 17340 taaaaagtag cattctaaaa ataaaaaac agtctgggca cggtggctca tgcctgtaac 17400 tccagcactt tgggaggccg aggggggcag atcacctgag gtcaggagtt tgagaccagc 17460 ctggccaaca tggtgaaact ccgtctctac caaaaataca aaaaattagc tggatgtggt 17520 gacgcacgcc tgtaatccca gctgctcagg aggattgctt gaacctgaga gacggaggtt 17580 gcagtgaggt gagatcatgc cactgcactc cagcctgggc aacagagtga gactgtttca 17640 ataataaat aaataaataa tagaataaa aatagttttg ttttgacata ataaaattaa 17700 aaagtgttgc tttatgctag gttattttt ccttcaaaaa cctcagtagg ctttcctgag 17760 ctgacctgag atgtaaaggc aagtatctgt gggccgtggc ttgagttgta agactaggtg 17820 aaagactttg tagcacagct cagctataag ttggggtctg cctttttgca tattgaatcc 17880 ttggttcttg tttcctaaga cctttccagg tgtcctgaga tggttctcca gttgagtttg 17940 tcatctgcca cgccccgcag caagcctgtg tgcattcata agaattcgga atgtctgaaa 18000 gagcagcaga aacgctactt tccaggtaat tggccatctc tggttgcttt ggaatatgtt 18060 gattgttcat tcatataaaa aattgactcc tactttatat tatatacaga atcaattcca 18120 gaggtttaag gacttaaata tgaaagccaa acctttaaaa cttttagtag aaagtgtata 18180 tgaataattg tatcattggg gtaggaaagc atttcctaaa ccagacacaa aggatcaaa 18240 cttaaaaaga ctgataaatt ttactacatt aaaattaaga actgttcctc aaaatatacc 18300 ttaaagaaag tgaaaagact gggcacagtg gctcatacct gtaatcccag cactttggga 18360 gggtgaggtg tggaattgct taagtccagg aatttgagac cagcctgggc aacatagcaa 18420 gaccccatct ctacaaagta gcagcactct actatgccag gctaattttt taacttttgt 18480 agagatggag tctccctgtg ttgcccaggt tggtttcaag ctcctggact caagcgatcc 18540 ttccacctga gcttcccaaa gtgctgggat tacaggcatg agccaccacg ccaagccacc 18600 agtctttttt tttttttttt tgagatgaag tttcgctctt gttgcccagg ctggagtgca 18660 acggtgaaac tttggctcat tgcaaccttc acctcccggg ttcaagcagt tcttctgcct 18720 cagcctctca ggtagctgga attagaggcg catgccacca cacccagcta atttttttg 18780 cattttcagt agagacaggg tttcaccatg ttggccaggc tggtcttaaa cttctgacgt 18840 caggtaatac acccacctcg gcctcccaaa gtgctgggat tacaggcatg agccactgcg 18900 ccagcccaa tcattttttt gatggacttt tatatgacgt ctaatttttt catttttaaa 18960 caatgctata atatacattt taccataata tacctgaggt gttctttaag gataaattcc 19020 aagtagtggc caggcacagt ggctcaggcc tgtaatccca gagctttggg aggccaatgc 19080 aggcggatca caaggtcaag agatcgagac catcctggct aacacagtga aaccctgtct 19140 ctactaaaaa tacaaaaaat tagctgggtg tggtggcatg cgcctgtggt cccagctcct 19200 cgggaggctg agacaggaga atcgcttgaa ccctggaggc ggaggttgca gtgagccaag 19260 atggcaccac tgcactccag cctgggcgac agaggagac tccatctcaa aaaaaaaaaa 19320 aaaagaaaag gaaaagaaaa aaaaattcca agtagtaata attacttgta actttagatg 19380 gatattgcca gattgtaagc taaaacatat acccaaatac actttgacca accaacatgg 19440 tattatcacg gcatttctct tctggaagaa gcttagaatc attttatcct atcaaaaaga 19500 aaaaaagatg gccgggtgag gtggctcaca cctgtaatcc tggcacttta ggagaccgag 19560 gtgggaggat cacttgagcc caggagttca agaccagcct aggcaacatg gtgaaactct 19620 gtctctacaa agaaatacaa aaattagctg catgtggtgg catgcacttg tagtcccagc 19680 tacctagaaa gctgaggtgg gagaatcacc tgagctcagg aagtagaggc tgcagtgagc 19740 catgatcata ccattgtacc ccagtttagg tgacagagca agaccccgtc ccccccaaaa 19800 aaaagtctcc atgctgtccc tttttagtca aactctcccc aaatccctaa cctctagcat 19860 ccattgatct gttgcctgta cctatagttg tgctttacag aatgtcaggt aagtgaaacc 19920 atacagtacg taatcttgcc aggtgttaag atggcactct aatgccttcc tcaccatcct 19980 tgtttccacc tctttgcctc gcactttgga tgtcagcaac acaaactgct tggagtgacc 20040 tgaatggacc ttgcttttta tttatttatt ttttttgag acaggatctc actctgttgt 20100 gcaggctgga gtgcagtggt gtgacctcag ctggctgcaa cctccgcctc ctgggtttaa 20160 gcgattctcg tgcctcagcc ccccgagtgg gtgggattac aggcacgcac caccatgccc 20220 ggctaagttt tgtatttttt gtagagatgg ggtttcacca tgttggccag gctggtgttg 20280 aactcctggg cttaagtgat ccaactgcct cggcctccca tggtgctggg attacaggca 20340 tgagccacca cgcccggctt ccttgctgtt tcttgtccct gagtgttagt catgtgccct 20400 cttttgacca tgtctctatt ctcctcttca actcactaac tccaagtcat cctttaataa 20460 tcagctcagg gctgggtgcg gtgacgcacg cctgtgatcc cagcactttg ggaggcccag 20520 gcgggcagat cacttgagcc caggagtttg agaccagcct ggccaacatg gtgaaacccc 20580 agctctacta aaaatacaaa aattagccag gcttggtggc acacgccttt ggtcccagct 20640 acttgggagg ctgaggcagg agaatcactt gaacccagga gacagaagtt gcagtgagcc 20700 gagatcgcac cactggtgcg acagagcaag actccatctc aaaaaaaaaa aaaaagaaga 20760 agaaagaaaa agaaaaaaga aaaaaaagaa tcagctcagg tgtttccttc ttcataaaga 20820 ctttcatatt ttcttctttc ctaaattgta cctttccttg gtattcacat aatactttct 20880 gtccttctct ctagttgtat tgaccacttt ttaccataat tattattgtc tgtttatacc 20940 agctaattag cgccccatca aaataagaat tgttatctt tttattacta atgtataacc 21000 tattgtagat acatagtaga gtcccagtgt tgattaattc ttctacgtat aatgatgatt 21060 actagcttgt ctgaggcttt tctaatttct tcccatcctt tccctgcta gtattttcag 21120 acagagtggt atatactcca gaaagcctct acaaggaact cttctcacaa cataaaggac 21180 tcagagactt aataaataca gaaatgcgcc ctttctctca aggaatattg atttttctc 21240 aaagctgggc tgtggattta ggtctgcaag agaagcaggg agtcatctgt gatgctcttc 21300 taatttccca gaacaacacc cctattctct acaccatctt cagcaagtgg gatgcggggt 21360 gcaagggcta ttctatgata gttgcctatt ctttgaagca gaagctggtg aaaaggcg 21420 gctacactgg gaggttatgc atcaccccct tggtctgtgt gctgaattct gatagaaaag 21480 cacagagcgt ttacagttcg tatttacaaa tttaccctga atcctataac ttcatgaccc 21540 cccagcacat ggaagccctg ttacagtccc tcgtgatagt cttgcttggg ttcaaatcct 21600 tcttaagtga agagctgggc tctgaggttt tgaacctact gacaaataaa cagtatgagt 21660 tgctttcaaa gaaccttcgc aagaccagag agttgtttgt tcatggctta cctggatcag 21720 ggaagactat cttggctctt aggatcatgg agaagatcag gaatgtgttt cactgtgaac 21780 cggctaacat tctctacatc tgtgaaaacc agcccctgaa gaagttggtg aggtatgctg 21840 cttgtctgtg ttcactttat tttcttgagt gactgtggct ggtgtggctt tcagtttact 21900 tgctaaaatt catattgtat ttaccatgac cagaggggtt taagagtaga atctgctttc 21960 tttgtttcat tggggaaaaa cctgactctg tttcttacag tttcagcaag aaaaacatct 22020 gccagccagt gacccggaaa accttcatga aaaacaactt tgaacacatc cagcacatta 22080 tcattgatga cgctcagaat ttccgtactg aagatgggga ctggtatggg aaagcaaagt 22140 tcatcactca gacagcaagg gatggcccag gagttctctg gatctttctg gactactttc 22200 agacctatca cttgagttgc agtggcctcc cccctccctc agaccagtat ccaagagaag 22260 agatcaacag agtggtccgc aatgcaggtc caatagctaa ttacctacaa caagtaatgc 22320 aggaagcccg acaaaatcct ccacctaacc tccccctg gtccctggtg atgctctatg 22380 aacctaaatg ggctcaaggt gtcccaggca acttagagat tattgaagac ttgaacttgg 22440 aggagatact gatctatgta gcgaataaat gccgttttct cttgcggaat ggttattctc 22500 cgaaggatat tgctgtgctt ttcaccaaag caagtgaagt ggaaaaatat aaagacaggc 22560 ttctaacagc aatgaggaag agaaaactgt ctcagctcca tgaggagtct gatctgttac 22620 tacagatcgg tgatgcgtcg gatgttctaa ccgatcacat tgtgttggac agtgtctgtc 22680 gattttcagg cctggaaaga aatatcgtgt ttggaatcaa tccaggagta gccccaccgg 22740 ctggggccta caatcttctg ctctgtttgg cttctagggc aaaaagacat ctgtatattc 22800 tgaaggcttc tgtgtgacag gaaacccaag cctaagaaac aattaagtgg ttctcatctc 22860 taattaactg tgaaaccatt taatccaaac atgtaagcac acactcactt attaagtcac 22920 atacttttct aggtgctggg gattgagaac gaatcgatgt aagattcctc ctttagggca 22980 gagacagacc actgacaaat acacagatag acaaggaatt tcccatggta aaaaaggata 23040 tcagtaatta gaggaccgtg agactcagag atgtgtgtgt gtgtgtgtgt gtgtgtgtgt 23100 gtgtgtgcgc gcgcgcacgt gcacatgtgt gtaggtagat ggagggggtg attattttgg 23160 gtggtcagg aagtgctcag tgagggaaga acttgtcatg agaatctctg agcgtgccag 23220 gcagactcgg atatttttat aaatttttaa catggccact tgcagaagag cttgaatggg 23280 acgtgcagcg agaatgtgaa ggatggagca ggtagctcat ctggccttgt aggtgccggg 23340 aacgggcaag acatgttttg aaatgtaaga tcacagactg ttttttgcaa gaccacatta 23400 tattacttta ttattttctg ctttttcttt taacgacatt agtgtttttg atcactatat 23460 tttaaaatgc tttttgtgag ccttttggtt atgtggaatc tgttccttag ctctgatttt 23520 ttatctttat ggagcgtctt aggttactac atgaaggtaa gactgccaca gtcccccagg 23580 gaggcacact gtgttttact gattgatttg aagatgatag agagcctagg gggatgagtc 23640 tattggactc aaaggttaca ttttgtttt ccatttaatt taataatcaa caaaacgaca 23700 aagtcagttt aatatctttc ttctgctgag tcttcaggat gttagctagt ctttcaaaag 23760 ccattgctac aaaagtgcaa attctcatt tcctgtgggt ctctagaaac tctctcaata 23820 tttaaagcca aacaaatcca tcttttctga gagacagaaa ctaaaaaatt cagagttaat 23880 tcactattaa aaacagcaag gccctgctat ttcccaagaa taaagaaatt taaaattctc 23940 attgtaagaa gtatgaactt gaagctagaa ttggtttatt tctggcagct acttacaata 24000 ttaagaactt tactttttaa atttgagaca atttcacagg aaagcaagaa attagtctat 24060 tgtgaaatgt tttacaact aacttggaat atactgcaaa tcactagtaa gtagagacac 24120 atttaagata aaatgattaa taaaacaatt ggtaattctg aataaggatc tgaataaatc 24180 cagatcacag actgttcctt taccaatatg taaaagaatg tgcaaaatta gtaaaaaatat 24240 acccaaaaat ttaccagca cagagaagca agaatggag ttcacctta cactaaac 24300 atctaataga tatgtatgaa aatttaaaaa ctagaaaagg ttgggcatgg tggctcatgc 24360 ttgtgatccc aggactttag gaggccaagg tgggaggatt gttgagccc aggagttcaa 24420 gaccagcttg agcaatag tgaccctg tctctacaa aaaaaaaaaaaca 24480 aaaaaaa taaataaat tagctgggaa tggtgatgca cacctggagt cctagctact 24540 cagaaggctg agcaggacg atcacttgac ctcagaagctc tgaggttaca gtgagctatg 24600 atcataccag tgcactccag tctgggtgac agaacagac cctgtctcca aaaattaaat 24660 aaaaaaaaaaaaaaga atttaaaagt tttataaa ggcatagcta ctatctcatc 24720 tgcccagtgt agtcatgaat agatgtcaca taaagaaag aaaaccagaa ttcttgttaa 24780 tatggccagt tgaagggtg gtggcggagg tattgagcag gcagctcagg gaatgccag 24840 ggagaccctt gagcacagaa actcctgatt gtccccagggg actctccgtg gacaggag 24900 ggattttcca ggatttcaca tgaattcaat gaagggggct gtgtcttatt cctggatgct 24960 ttgcctcctt catggaatttc agtggatttta atggagttc ctaggcaaca ataagagta 25020 gaaaccaggt taacagcgag ggcctcatct cacaccagat catacaggc tacacaaag 25080 tagatggaag acaccacca ggcctccagc tatacactgg agagaagcc aaactagtct 25140 acttcatcta agaaagttgt caagagc ccttctatac tatctttagg taaaaagaaa 25200 gacttaccc agctgccctg attaagcatt agaagataa gtgttctgat cattaggcga 25260 aagacaatgg ggaaaaatgt agaaaaaaa tatgacatga gccagatgaa gaacccatcc 25320 tgaaaggata tataactcag gggacaaag acaactcacc ataagttggg cgcagtggat 25380 cacgcctgta atctcagcat ttggtaggc ggatcacctg aggtcaggag 25440 ttcaagtcca gcctggccaa cgtggtgaaa tcctgtctct actaaaaata caaaaattag 25500 ctgggtgtgg tggtgcatgc ctgtaatacc agctactcag aaggctgagg caagagaatt 25560 gcttgaatca aggaggcaga ggttacagtg agccagatc aggcattgt acttcagcct 25620 25680. gggcgacaaa gtgagaccct gtctcaaaaa acaaacaaag cctccccata gatgtctcct gccatagaag aatttaaga gttcataaat tcaataaaac aagagttgaa ggcctgtccc actgtaccca atttctccct ctctgaactg cagcctagaa actctctaca ggcagtaagc tggggcagtc acagaggtga cctcatctgt ttcccacatc ctgcattagg acagtgatca gggatcagta tccttcattg actgatttcc aatatctcga gacctgttgt ttcatatatt ttgccttatt ttgcaattgt ttcatatatt ttgtcttatt ttgcaattgt ttcaggaggg 25980. aggataaata tggtccctgt tcctctatct tgaccagaag catctaagaa ggcagtgaag caacatgtgt acagttctta gggaaacaaa ttttgaccta aaaatattaa acctagtcaa aatattattc tagtacaaag gcagcacatg ggtatttttg aacataaaag agttctagaa atacaggacc catgaatcat tcttgaagaa aagttactca gtaaggaaat ctagctaagc 26280. aagcaacatg tacaaataaa agattatt aattggacca aagttaagtt taaatccatt cacatgtata taattaagat atataggaat tataattaca gaaaagaatg ttacaaacct 26340 tcacaaagta aaaatatttt tatatcagat agattcttct gtttcaatcc ataaaaccag 26400 ggtttggatc atttaaaaa aacaaacaaa aataatttat tggaatcatt agggaggacc 26460 tgatagaata aaatgacaag ctgaccaaat aggccttaga aggagaggt gcctgggcag 26520 ttacaaggac ctaggtagca ggggtgactt ggccacagtc atttcttta cttgatttaa 26580 ggaggttaaa ttacagtgag agagttgcac ttatttagtt tgcataccgt actcaactct 26640 tagctagcat agggcaggtt ccttagttga aaaatttcca caaaacatga tgtaaagtgg 26700 aaagatcagt tcccccaaag aatatcagtt accaaagtag gatgaaagga tgttgggtag 26760 atcaaaacaa caaatgtcca ttacagcaat taacaaaagt tagggagtgg ggaagtctga 26820 gtgctaatat ggatttcaaa acaactttaa aaatggcttc aaacatttta tgctttttgt 26880 aatttagtca ttttaatatt agataaatct tcctgtaact gaaagttctt gagttaaaga 26940 aaaatattcg gtagttcagc tcttccttca attttattag ttgctttttc ttttgttcaa 27000 gtgaataaa cataaaaata atttttaaat attatgtac atatccttcg atttacata 27060 attctatcta gctgttctta tattttctct gatatatttt taaaagcttt ctggaatatt 27120 attackaccttg atatttcta gttgatgagt ttatgagtga tttattgctt ccttttctct 27180 ttcagtattg ctagaattaa ttttattgac ttgcccctt tgcataaga ccttgaaggt 27240 cacatgctga aatcgccctc tactaaaca aactcataga ataatgggg agatatttc 27300 aaaacattgc catatgcata gccatcctca caaccaagaa aagcgccctct ccatgaacta 27360 aaacctatga gtcattggta caggtaggga aaatctaggt aaaccacggt atacactga 27420 ggctggcacc accacaggcc aggacaccg ttgtcacaa gccaggacag aatctcccag 27480 ccagaaagtg ttgccctgag gctgaagcca aattcatttt gccccagtt ggccagacca 27540 aagcctagaa ctaaaaaacc catacctcag gtttgtcag cattggcact gctggctttt 27600 tgggctggac aaccatttat tgtgagaggc ttctctatgc actgtaggat gtttagcagc 27660 atccttggcc ctactcccta gacgccagta gcaatccac caccctccct cccctacccc 27720 agggttggtt gtcagttgtg acaaccaaaa atgtctccag acatcgccaa atgtcccttg 27780 gggggtaaaa tcaccac catacccttt ttgactaaaa gagttttccag atagtggca 27840 gatatatatag gtcaagcata acacattaca atcaatttc agacatca agattcttt 27900 ttaatcctaa aagaaaaagt ttggaaatc tacaaaaga agtgtgaatt tgacataac 27960 tatttcacta gcaagggtag acgtaagcag atacaggta gcatattcaa actgctgtgg 28020 aaaaaaaca tcaacctag acttctctcc tcaactac attcagagtc gaggggcaaaa 28080 taaatagatt ttctgacttg gacaagtag gatataatgta cttatagtat tcatcttcat 28140 acagggatgg actataagtg atttttaaaa acttcctac ttgttccaag tcagaaaaac 28200 tattcatata gggatgggct attagcaaga gtatatgaat aacgtactat aacaagaaaa 28260 aatgaattga gagaagta gtggtttta gagaaagg agaaaata attagtgaa 28320 actaaggtt aagtctatac atattattt ctaattgcct attatgtcag actacatgta 28380 gttagaaaat acgatgaaag aaaaagccat atttaatttc caaaaaag atataaaat 28440 windows tgcacaaaataagt tctgcacaa windows catgaact 28500 aaagagcaca aaaagaact tAAacagata aaagcagac cacgttttg gatagaga 28560 ttaaaatta taaatatatc aattttcact gttaatctat aattcagtg taatcccaat 28620 aaaaatgcca acaggttttc cccaatagca ttgaaatgat ttaaattt aatgaaggcc 28680 aagcatggtg gctcactcct gtaatcccag cacttgaga ggccgaggca ggtggattgc 28740 ctgagtccag gagttccaga ccagcctgga cacatgtg aaatcccgtc tctatttaaa 28800 atgcaagaaa ttagctgggt gtggtggtgt gcacctatag tcctagctac tcgggaggct 28860 gaggtgggag atcacca gccttgggag gtcgaggctg tagtgagcca aaatcacatc 28920 actgcactcc agtctgggca gccagagtga gaccctgct CAAAAAAAAAAAAAATTATTG 28980 gaaactacga ggcaagaata tccaagaaa atcgaaaa gagaaacct gagtgagtca 29040 gcatgaccaa atattaaac atcttataaa gctacaataa ttaaaacaat gtggtgctga 29100 tatgtggagg gtcaatggaa caatgaaa tggccaaaa taatttaaa atacatgttg 29160 aaatgtatta acagcatatg ttaaagttaa gttatgttaa ctttatatgt taattcaag 29220 ttaattgggg aagatggat tattcaat atgatgaca actctgtcac ccagctaaaa 29280 aaaattaagc ttgggccata tgccagacta gataccaaaa taaattccag gaggaccaag 29340 ttttaaaag taaaaatg gatcatgga agtgcatgaa gagaagtag cacttaaaaa 29400 ataataatc tcagcatggg gaggtctaa gtatggccct caatcagaa ccaggagga 29460 aaatattgac tattttaac aaaattatct ctgtaccaa aacagcataa aaggtcaaga 29520 aacacacac tggaaaaga attgcaatga attcacagc caatagtta atttcttatt 29580 ttcaaaaat agcttctaca atcgagag aaaaattcta aggtctcaa ggaaaaatga 29640 gcaaggatt tgacaggtgg tagatacag aaaagaatt tAAatagct cctaagata 29700 tggaacatt actcatgata gcagaagtat cattgacaa attackcag attggtaca 29760 aactttaagg gggaaagcac ttccatgcat tgctgtaaat tggtacatct tctactgaga 29820 acaatccggc agtagttaac aaaattgtga atgcatatat ctctttctct agaaatttct 29880 cttttgggaa tttattctac atatatattc aaacgtgtga aatacttcta tacaggtgat 29940 tgaatttcac tttattccta agagcagaag actgcaaaat agtaaatata tacccaaaag 30000 ggtctaatgg attagtttt ggcatatcag cacatgataa tactatgaag ccataaaaaa 30060 gagagatctc tatatgtatt gatgggggac catctttaag atatactgtg gtgttgaaca 30120 aaacaacatg ctgaaaatgt ctcttattct tttagaatca atataagtct gtgcttgtaa 30180 atgcagtaag tatctttgga agtataccta aaaattggta atagtgtttg actccaggga 30240 agaacagatg ggtgccagag tgaaaaaaag atagcttttg ctttttatga cttttggatt 30300 ctgtaccacg tataattt gatgtaaatt ttgctgtgtg tgtttttact tgttcatgta 30360 gtgattttat aaattactct tttaattttc tatcaatgaa tatcctggga taaacccctc 30420 atgatcataa tgaataatga tgtgtggaga gtggggaggg tttacatatg aaaaatgtag 30480 aaaatacaaa aagtgtctat atatacaaaa atgtaagtgt taacattttt atatttgctt 30540 caagcttttt ttttaaataa aagaaatgca atattgcaat taaa 30584 <210> 5 <211> 20406 <212> DNA <213> Homo sapiens <400> 5 attgtgcggc gctggtcccc tcagagggtt cctgctgctg ccggtgcctt ggaccctccc 60 cctcgcttct cgttctactg ccccaggagc ccggcgggtc cgggactccc gtccgtgccg 120 gtgcgggcgc cggcatgtgg ctgtgggagg accagggcgg cctcctgggc cctttctcct 180 tcctgctgct agtgctgctg ctggtgacgc ggagcccggt caatgcctgc ctcctcaccg 240 gcagcctctt cgttctactg cgcgtcttca gctttgagcc ggtgccctct tgcagggccc 300 tgcaggtgct caagccccgg gaccgcattt ctgccatcgc ccaccgtggc ggcagccacg 360 acgcgcccga gaacacgctg gcggccattc ggcaggtgag acccccacgt tcgcgcccct 420 cggtcctccc gagagctcgg acttctactt ttccttccca gggttccccg atcttctcag 480 gacggccttc ccacttcctc attcgtccac aaggcacact cccggccctt gatcgctccc 540 agtgtctagg gatctccgga cttgaggttt tatatttaca gaagacagca gatatgtata 600 tagtttctgt gcgcctgacg ctaaggttac atacagccag gaacaaggtc aaaagtgtcc 660 ctggtttaca gagtgtacat cggaatgggg gaggcaagcc ttaaacaagt aaacacataa 720 atgagataac tttaagagag tgaaaggtgc aatgaaaaa tcgggggaac tcgaaggaaa 780 gagttacgct attttattta gatggaatag tcaagagaaa tcgtctccga agaagcaaca 840 tttgaacaga aaccggaatt ataaggagcc aggcaggtgc agaaggtcct gagatgggaa 900 tatatataggg gtgttcaggt aacagaagag gcagtgtgtg gcctgacttc aagaagaga 960 aaaagaactg gtgtgtgaat gagaatgaaa atgggtcagg tcaaataggt tcttggtcag 1020 taattgaggt tagtctaaat agatcaccct tcaaagaca tacgtttgct tgtcttgtaa 1080 atcacttgag tcatttcctt atcacctttt ccccagacac acacattcgc actcgcacaa 1140 ccctggcagc tggactcaca tcagtttctg ccccctcctt ttcacaaggc actcctgaaa 1200 cttttgatac ctcccagctc ttggcattct cctagcttca taataatgac agcttacaga 1260 gagggctttt cagtggatta ggcacttttg catctgtgta aatatatctg attctcttct 1320 tttttatttt tctctctctt cttccttcct tcttcttctt tttttttttt ttactttaca 1380 gagtctcact cttttaccca ggctggaggg cagtggtgca atctccacgc actgcaaccc 1440 ctgcctcccg tgttcaagcg attctcgtgc ctcagcctcc ggagtagctg ggattacagg 1500 cgtgtgccac cacgcccagc taatttttgt atttttagta gagatggggt tctgctatgt 1560 tggccagact ggtctcaaac tcctggcctc aaagtgatcc acccgcctcg gcctcccaag 1620 gtactaggat tacaggcatg agccatcatg cctggcctcc ctcatttcct ttttttttct 1680 tttttttttt cttttttttt aaacgaagtc tcactgtctc ccaggctaca gtgcatcggc 1740 gcaaccccag ctcactgcaa cctctgtatc ccaggttcaa gtgattctac tgcctcaacc 1800 tcccgagtag ctgcgattac aggcatgagc caccgtgccc ggccaagatt tatactttta 1860 aagctgcact ctggcccatg tggagaatgt actgtgggtg taatttcatt cctttgccac 1920 tgtttatagt agtgtatctg ttttggaat acaccact cacatttatc aagttttttcc 1980 ttctatatct catttataat ctaccagaaa ttctagcact gtcagaaatg tatatatgta 2040 tgtatacatt cgactttacc ataatttta tttatttatt tattttg acagggtctc 2100 tctctgtcac ccaggtttga gtgcagtggg gcgatctcaa ctcactgcaa cttccaccc 2160 ccaggttgaa gcgattcttg tgcctcaggc tcccagtag ctaagattac agatgtactc 2220 ctccactccc agctatttt tgttttttgtt tttagtaga gatggtgttt tgccatgttg 2280 gcaaggctgg tctcaactc ctgacctca gtgatccacc tgcctcagtg gattacagag 2340 tgctgggatt acaggcaag tgctgggatc acaggcatga gccactgcct ggccagcttt 2400 accagtactt ctagttatt ccagtattg agataaaag atgaatccct ggttctaatt 2460 cacatattag tatatatagg agatattgca agttcagttc cagacctgag taatagtca 2520 aaagcaa tatagtata aagggagtca caattttt ggtttcccag tgcatataaa 2580 agttatgttt acactatatt gtaatctatt aagtattgtg tatgtatata tatatatata 2640 tatatatag cacatacaca cacatatata ggtttcatc catggttcct ggctcataac 2700 tctcagccct tgctacagta tttgttagg catcctaggc cttaggagca ggccttggga 2760 aacagaatct ctcctgccct ccttcacct accxaggc aggactggaa tctttccctg 2820 tctttcaaat tgtgagtctt agaccctcc tcagagaggg accccaccct ataccctggg 2880 ggaaggaatg ctgacatcat gaagctcca taaaaaccta agaggatta aaaaaaayaa 2940 aactaaaata aacctaagag gacttgaagc caatggtca gaagttccat aggccccagc 3000 ttgctatttg tgtctggagg agggtggggt gcagtcttgg ggaccaagcc ctcacctat 3060 gatctgacac tatctccagg tagatagt gt caaattgag ttggatta cccagctggt 3120 gtccactact tattggtggg gaaaaacccc cacatttg gtcacagacg tcggggttga 3180 ttgttgtgag agcagaggga aaatgtgatg tgtttttcca aaatagtcgt acatctgtat 3240 cacatgggaa aaggaaaaga tttaaaaa gcagaaaaat ctccaccat aaggacgtt 3300 attgataaat ttgactatat tacctttaa gatgtgtttta aaggacata ataaca 3360 atggctaaca tttattgaaa tcttaactat tcactagcac agtgctctgt gttgtttatg 3420 ggtacttaaa taaaaaccgg taagggagtg acatgagaat gatatacacc aactttaaga 3480 tggtattac ctctggagag gaaggagga gatgaaagg gagaatttca gctgtatctg 3540 tagtgttgat agtaaaactg aagcggataa gagtgcaact tctactgcat cctagcttgt 3600 gcagccctgg gcaagtttcc tactctct tgtctcagt ttcttatct gttaatgag 3660 atattaata gtacctgctt caggggttgtg aggatcaaat agttaac atttaagca 3720 cttagaagag tgcctggcaa gtagaaaagg ctcaataaat atagtttt gtttttgtttt 3780 ttgttttagt acagaaagag actgaggaaa ttaggtcaa atattcacat atgttaaatc 3840 ttttttactg tagatgttg caatagacca tgacttaaa tattttttaa aaaattaaa 3900 atcttgatca tagctgggca cagtggctca cacctgtaat cccagcactt tgggagactg 3960 aggcaggagg attgcttgat ctcaggagtt cgagaccagc ctggacaca tggtgaaacc 4020 ccatcttac aaaaaataca aaaattagct gggcatgtg gcacgtgcca gtagtcccgg 4080 ctacttggga gactgaggtg ggaggatggc ttgaacccag gaggcggagg ttttagtgag 4140 ccgagatcat gccactgcac tctagcctga acaacagagc cagatcctgt ctccaaaaaa 4200 aaaaaaaag aaagaaatct tcatcgtaat gagcatttca catctttatt gtgatgagga 4260 agccaaggaa gcaaacatta aatagtgtgt ctccagagga gcatggctcg tgtaatttaa 4320 ggttcaaatt ctctttttag ataaattcta atctacctca tcaagcttaa caacttatgg 4380 gccaacagcc agtgctgctt acataaacaa aatgtgatat gtcctagaag caggcgtggt 4440 gtctttgtgg tagagggtgg aattaaacca acaaaaacct gactcattta tgccaaagta 4500 gtgaaatatc tgactaatca acaaccgtag ggtgatcatc agaactgctg taccaacaaa 4560 tagtgtaggt aaacagtgga attgtctaag tattcataag ccattgatga cccatatagt 4620 taaacatcca gagaaaacat aagttcctga agtctcctag tcttccactg tgaaagtaag 4680 aagagtggga aaattaaagt ttttaaggaa tccatcagtt aggaattgaa gtaaggttat 4740 atacacagaa aacagaaaca gatcaggatt gctgtttggt gggggaagtg gaaggaaaat 4800 4860. cttaggagcc ctgctggtct tttgggtggt tagatgcaaa fathergtttg tggccatttg acagtaatat tcttgatgtt tttgttaagg cagctaagaa tggagcaaca ggcgtggagt tggacattga gtttacttct gacgggattc ctgtcttaat gcacgataac acagtagata ggacgactga tgggactggg cgattgtgtg atttgacatt tgaacaaatt aggaagctga atcctgcagc aaaccacaga ctcaggtaag tagtttattg tcacttaaac agatcttttta gcttttattg gaaatgacag acactggtgc cttctaatta catctgcccc aggagagttg tcttgttttg ttttgaactg tacgtaggtc ttgtaagtaa 5220 tgagcaagtg ccaggaca cagaaatttg gcattatgtt tttaatcttt cccactgagg ctaaatttgg cttcagaatt attgtcaaga fatherctgtc tagtcataga atcatgaggc tgaaagtcat tgcttggcaa tcttcttgcc ttcaggtgta ccaagaagca aattatacat tcattaaag cttcaagtaa cattataata tcacatttta acttaaccca tttaattctt ctgatcctca taacaaactt ctgaggaatc acagaattgt aggaatag agtatcctag aaatcatcta gaatagcact ttgcagtaga actttctgca atgatggaaa tattttatat 5580 ctgcactgtg tatatggta ggtacttgtg gctattgagc acttgatatg tggctagtga 5640 cacgaggaag tgaattttta atttaaatgt aaatttaaac tgaaatagcc atgtgtggct 5700 accatatagg atactacaga tctagatcaa tcttgccttt agatataatc ccagaaaagt 5760 taaattattt actcaagggc aaataactag ttcataaaga agccaaaact agaatctatc 5820 ccaagtttta gtccaaatca tgctgttttt agctgccccc aatgtctttc aaccctgtaa 5880 gagcaaaagt tctttcagtg tctaatttaa ttccttcctg gtagagtgta aacgtagctt 5940 ccaaagtata tacactagag ctaatcttac aagatgttct gcaaaaacag ggttcaagta 6000 agatcaaaca gtgtattctg aatacttctg ttgtggataa acagtccaca tcagctgatt 6060 cttacttgta acttagcttt tctcaaactt acatgatcac agaacctaca tcctcttccc 6120 cacttacagc ggtaaacacc cttggaattg gtatgctgag tatatactg tactttggaa 6180 tgtggttatt taaatccctc tctgcttgtc atctttgcag tactgaaaag ggtgtgctca 6240 ctggttattc atgtataatc attatchag acatgatcg attctctgg aaaattaagt 6300 atttgaccca acagttaagt tatacttttt cctaaagat gatccagacc tgttttccta 6360 ggatctgaaa aacattagtc tgccgaagga agtcatactg taggcagga agaatattgg 6420 taacacttga gattatgag tccaagttgc tagattgtt ctgagtgtc atcagatact 6480 gtattgctct gcttatgcaa gggaaaggct ggtttgaata ttataatgac attgcagcta 6540 aaaatgtc aggttcaag ttaatactta aaagcaaaat gtttagggtc atcattaccc 6600 ttaaaaatcc tttaagggag cactgagtcc atttctctgg aatttgtgca tcctaggaaa 6660 aaaaattgtg attttcaaa aatcccttaa gagacagca aaggcacat attatctcag 6720 tgtctttaac acaccagtc ttgctccac tattggaaca gagtgtgttc tatgattgaa 6780 aactaaatga agtaattggc tgtgtttac ggattatgtt gtgggaaaa atagatattt 6840 tcttagaat tatgctcagt gtgatgagat gcttgtcctg agaggagat aaggaggaaa 6900 ctaagatcag ccaaggaat aaaattca ggtctcccat ctttcactct cagggaatag 6960 aaattgatta gaatggctgg gataattgcc tgtaatgttt aaattatcct tatctttttt 7020 tttttttttt ttgagttgga gtttcactct tgttgcccag tttggagtgc aatggcatga 7080 tcttggctca ctgcaacctc cacctcccgg gttcaagtga ttctcctgcc tcagcctcca 7140 gaatgctggg attacaggca catgccacca cacccagcta atttttgcat ttttagtaga 7200 aacggggttt cgccatgttg gccaggctgg tctcgaactc ctgacctcag gtgatctgcc 7260 tgcctcagct tcccaaagtg ctgaatttac aggcatgagc ccactgtacc tggcctatcc 7320 ttaccctttt ttaaaagcat gatcttacag ttgaaataat gcagttgaat tagcattaag 7380 ttaaataata attttattat gagagaaaag ctaatttctt ttgtatcaag cacttagttt 7440 tcattttctt tatcagaaaa ttatgtctta gaacattat tattttaaac agttgcactt 7500 aataaatac acaatacagt taacagattt atgtattcct aagaattcct cctgcatagc 7560 attctattag ggaaattaca atctgaaaat taagtctttg agttttccaa aggtggcata 7620 tactctgccc tttgggaagt agggttatta ataatgttat taattcaata gaaattcagt 7680 gatttcttaa aaattaaatg atttttgttg ttgttgctgg tctttggtca agaatatctg 7740 tatttgaaca catggaggtt cctgaatgat ggagcactca gaaagggcat ggaagctcta 7800 tgccccttc cccatacctc accctatgca tgtcttcatc tgtatgctgt gtaacatact 7860 ttataataaa cctgtaaacg tgtttgagtt ccgcaagcca ctctaacaaa ttaattgaac 7920 ccaaggagga ggaggtggga acccaattt atagctagtg tcagaagcac agaattacca 7980 gaaaaggaaa acaaatcaaa acaaaacaaa acaaaaaaca gaaaaataac atccattata 8040 caatataaga aaccaaagac catcaatctc taatctctgt gctcaggtgt ctgtgtgctt 8100 caattcttct catctacgag tcttgggttt tcaatgctca cttgtcacca ggatatgaat 8160 taaaaatgtc ttgggcacca ccatgtggtc cagttgtctt aacctttcta aaagtgcttg 8220 tgcaaaccat ttacttgttg cttcttacac aattacagcc caacctactt gtgtttaaaa 8280 gcaaccacag catgtttgaa agtcttatgc aataaaaggg aagtttatga ttacatttag 8340 tctgtactta ctggatactt tcagttttat cagttccaag tacagcaaac tctggataat 8400 atggttaatt acttcctcca tgattcttc gaccttcata tcaatttgc taaatatgga 8460 atgattgact agccagagca atcaggaag agaagaat aaaggcatc CAATTTGA 8520 aaagaggaag tcagattgta cctctttgct gandacatga tttgtatgt agaaaaacct 8580 aaagacttca ccaaaaaact gttaaaactg aaaaaaat ttagtaaat tgcaggatat 8640 aaaatcaacg tacaaaatc agtagcatgt ctatacgtaa atatgaact agctgtaaaa 8700 gaatcaag aagtaatccc attackattag ctaccaaaaaaaataca aaatacctag 8760 gaataat aaccaagag gtgaaagagc tcttacaagg aaaactaca aacactgatg 8820 agaaaactta agaggacaca aatggaaag catcccatgc tcatggatca gagaattta 8880 tattcctaaa gtgaccattc tactcaaat atttacaat tcagtgcaat ccctatcaa 8940 attack cattctcag agaatagaa agcaacaat cctaaaatttc atatggaacc 9000 gtaaagaagc ccaatagct aaagcaatac tgaaaaaa ggacaagct ggacatatca 9060 cactacctca ttcaagata tactacaaag ccacagtaac caaacagca tggtattggt 9120 aaatactg acacacac acacacac acacacac aaaacagata 9180 catagaccag tggaataca tagagaacca agaataat ccatatattt acagccaact 9240 gattttccat gaaggcacca agacattac agtggggga aggactctc ttcaatact 9300 ggtactgggt aactggata tccatatgca ggataatgaa actagacccc tatctctcac 9360 tatattaa aaatcacac aaatggatt aaagtttta atttagacc agaactata 9420 aaactactag aagaaacac agggaaag ctctgggaca ttgatctagg siaagatttt 9480 atggctaaga cctcaaagc acaggcaca aaaacaggca atgtgacta tattaaacta 9540 aaaagcttct gcacagcaaa ggaataatc aacagagtaa aaagaaaacc tgttgaatag 9600 gagaaaat ttgcaacta ttcaacac aagtaacta tattccagaat atachaaggaa 9660 cttaacagca aaaaacataa taatcccatt aaaaacatct attcaatcc taatttgaat 9720 aaacattttt haaagagga cacacaatg gccacaggc attgaaaaaacacaaa 9780 ttattaggga atgcaatc aaaaccaca tgaagtacca tcttatctag ttagaatggc 9840 cattatttaa aagattttta aaatacaga tgctggcgag gatacagagc aaaggaact 9900 cttatattct gttggtggga atgtaatta gtacagccat tatggaaac agtatggagg 9960 tttctcaaaa actaaaaat atagaactac catacaatcc agtaatccca ctagttggta 10020 tctatccaaa agaaggaaa ctagtgtatc aaaggcatac ttgcacccc atgtttattg 10080 storm storm storm gcc agatacaga atcaccta gtgttcatca gtggatgaat 10140 ggataactg tggtaatat actcaatgga atactgta gttagccata aaaaaggatg 10200 atatcctgtc atttacagca acatggatgg aactgaaggt attatgttaa atgaataag 10260 ataagccagg cacagaaagg caatattac atgttgtcac tcatatatgg gagctaaaaa 10320 agttgatctc atggaggtag agaggagaat gatagttacc agaggctggg aagggttttgg 10380 ggttggggga agaggagaat aaggagaattt tggttaatga gtacaacat acagttcgat 10440 agaaggtata attctagtg ttcaataca tagtaagtg attatagtta acatctgtt 10500 gtatattca aaatagctag gagatttaga tgttcctaac aaagaat gataaatatt 10560 tggggtgatg gacatcctaa ataccctgat tttatcatta tacattatgc gcatatcaca 10620 aaaatatgtc taagtgtata gcaataaaaa tgtggaaaaa agaatatcta taatttggtt 10680 caaattatta footggaca ggcgcagtgg ctcacacctg taatcctagc actttgggag 10740 gccaaggcag gtagatcact tgaggtcagg agttcaagac cagcctggcc accatggtga 10800 aaccccgcct ctactaaaaa cacaaaaaat tagccaggcg tggtgtcaca cgcctgtagt 10860 cctagctact tgggaggctg gggcgggaga attgcttgaa cctgggagtt ggtagttcca 10920 gtgagctgag attgcaccac tgcactccag gctgggcaac agagcaagac tccgtctcaa 10980 aaaaaaaaaa aaaaatctta aagtaaaagta tctttggact ttgctatggt cgaaaaaagg 11040 aagttggaga aaacactctt tccttttgat tgagagacat atgcaaaatg tttgttgcaa 11100 tacagtttat ctgtttctct tttttcctac aacgtatttt ctcttctctt acaggaatga 11160 tttccctgat gaaaagatcc ctaccctaag ggaagctgtt gcagagtgcc taaaccataa 11220 cctcacaatc ttcttgatg tcaaggcca tgcacacaag gtacagttta aattgtggac 11280 ttcactttgt taaaaagaca tcttatttca ttgacggtca tttccgaagt tacatatatt 11340 ttgttatttta ttctttttaa acttatttt tataaattgt atttgtttta tggagtgta 11400 caatgcagga atctatatca ttaggaaa cagtgcatta tggaactttt taacctttta 11460 tggaaacttt acaaaccag cataaaatgg agagtcaag tttcttat ttacataag 11520 catttacaa agatattaag taacagtaa aaagacatt tctagaaaa aaccactgta 11580 gtaaccttga gttacttga aaaaaggaat tccgaagttg tacacagac caatttatc 11640 tagcttaaa gttaagggcc ttatatggac aactatggac tgcatttaaa gagaatttcct 11700 atattaaag cttctaatag ttacagac atacctttt tacatagatt tatccctttg 11760 tataatttat atcccttatg tatagttttt tattcattga tttagcagt tatacttta 11820 tcagaaaatc atttattc ttcaatgta tttgacattc ctagataaaa tttgcttaa 11880 attttaggc ctgcacttac accataga acatattatt acagtgaaaa tcagtgggaa 11940 gatatgattc tgattacatt tgttctctta taaccagctt ttcagtgca agtacttttt 12000 tccccattg gggcaacttga gtatttttcc cctagcaata ttaataatcg gtaagggcca 12060 tctactggtt gagaattctg atgatgccaa tttttttt taattaatcc catgatatca 12120 ttgaaaccag ttgttaaaac ccaaaatggg ccggtgcag tggctcacac ctgtaatccc 12180 agcactttgg gagtgatca cctgaggtca ggagttcgag accagctgg ccacatggt 12240 gaaacccctg tctccactaa aaatacaaa atttagctgga cttggtggcg ggcacctgta 12300 atcccagcta ctcgggaggc tgaggcagga gatcgcttg aaccggggag acagaggttg 12360 cactgagccg agatgcgcc agtagtactc cagcctgggt gagagcga gactccgtct 12420 aaaaaaaa aaaaaaaacct gaatgtgga gcctaagtat acacttaat tttaca 12480 gttaatttcct atttttgaag aaggagata atgtaacta atttatt ctagtaacc 12540 gatagttgta tacgtctagg tttccaatt ggtctgcgtt agaatcacct gtacctattt 12600 12660. attcctgggc cattctccct agggagaga ttctgaaaat gtctagggtg ggctcaagga acatgtattt ttaatgagca cctcaggtgc tcattgttga tgttgcagcc cacatttggg aaccctgata ggtcctacat ttcacccatg gtatactgac ttttatgctt attctcttag attttttgag acagagtctc actctgtcac ctaggctgga gtgcattggc gcgatctcgg ctcaatgcaa cctctgcctc cggggttcaa gcaattctcc tgcctcagcc tcccaagcag ctgagattag aggcatgtgc catcacaccc ggctaatttt tgtatattta gtaggatgg ggttttgcca tgttggccag gctggtctca aactcctggc ctcgagtgat ccgcccacct tggcctccca aagtgctggg attackgtg tgagccacca cgcctggctt 13080 ctcttagaat actttttaaa aagaagtaga catttaaaaa agaaaatcta gctatttgag tcttctgaat gggtgctcat gggtgttcag ccaagactgg gtagaacata gtgacctaat tcaccaagat ggtagtagaa aggcacaagt gtaggcaaca aagtggagct agtagcac agtggccaaa atcatgggct tgggactcca acagtccttg actgagctct tactacaggg taaccttaac tttgatgagc ttcagtttct tcatgggtaa aatggggata ctaaaagcag 13380 ttaccacata aggttgttgt gagaattaaa taatgtaaat gctaagagtt tacagtgcat 13440 gtctttgttc aaacagaaaa aaaaatgctt tctatagctt gccttcagtt gcattagcga 13500 agaggaggca tgacatggat aatttgtgtc cttttttatt ttggtggggg aatgcatttt 13560 gctcatcata tttggttagg ggtatgtgta acattccaaa aattagcagt gtttcacaaa 13620 ttatgcagca gcagcattgc gtcccacatg gctggtgact ttcttgttgt tagctgctat 13680 tgatgtcact tcactagggg ttaccaaata atacttaaat tctatcatgt cttcttcatt 13740 tcgtagctag actactataa aaagaaactt ctgttcacct tgggaagaat tgggagcccc 13800 ttaactcttc ccagtccctc ctacccttgc cccattactt ctccctccat attggtgatg 13860 ggtaatgcgt cctctcagtc ccctggactg agaaatctat cctctgtagt tcccagactg 13920 gctggctcat gtttcattta gaaaaggcac agagtgatag agctgtgggt atgaaaggac 13980 ttttcatagt ggctaaacta gggtataagg caaggaaaaat tttgcctctg gcctcatctg 14040 acctacggct taccacactt ttcaaaagta ttccaaaagg ggtgaggccc tcagagggag 14100 taagcagca gtactccacc ttcttccttg tttgctgctg gtgtgagttt aaaatgcatc 14160 ccagtggata atagactcta ccaatacttt footcctcc atttctagta aacttctgtt 14220 ttatccata gggttgtact taatatgtga tagttatgg ctggggctat ctatcacatt 14280 ttaatcaatt ttaaatat gaatctcttt attttacagg ctactgaggc tctaaagaaa 14340 atgtatatgg aatttcctca actgtataat aatagtgtgg tctgttcttt cttgccagaa 14400 gttatctaca aggtaacatt cgggattttt cttgtcata ttaggtgagc tggtgtagat 14460 aattgcaatg ggctgcgtaa gcacaggata gatgcctatt aaattgaact gcatcagggt 14520 cacagttgag aagctcctct tttaaattaa ccagagaaat tccagaaggg gaatgtactc 14580 ataccctta cagaatgcca ttatccctct tttgcccctt cttttatgtt gtttataggc 14640 tcactcagat tactgtagta aaattctcac aacagaaaag aattatgtag cccctacttc 14700 tcaccaacta acagcagaac ataccttcat aaaataatt cttaattatg gagaatctaa aacatgcata aaataagta gtagtgtacc ccccctttaa ctgtgatcca gctcatttca cccataaccc cattgatcct ccccagtgtt attttgaagc aaatcttatt ccatccataa aattgcatta agaatcttta aaaagtgatg ccattttatt tatttttt ttttttttt tatttattta tttattttaa aagacgggtt ctccctcagt ttcccaggct ggagtgcagt ggtgtgatca cagctcactg cactcttgac cttccaggct caaatgatcc tcctgcctca gccttccaag tagctgggac cacaggcgca cgtcaccacg cccagctaat tttttatttt tattttttgt agagacaggg tctccctgta ttacccaggc agttctccaa ctcctaagct caagcaatcc ttccacctca gcctctcaaa gtgctgggat tacaggcatg agccacagta accagcctag tgatgccttt ttaaaaacat agccacaatg ccattgtccc atctaaaaat fathers aaattattca fathers tatccagtgt fathers acttgtctcg gaaatgtcat aaatggttgt ttttcataaa ttgctcattc gaataggacc caagtaagat 15420 cggcgtgtta caatcgtaaa tctttttttg tttgtttttg agacggagtc ttgctctgtc 15480 gcccagtggt atgatctcgg ctcatcgcaa cctctgcctc ccgggttcaa gcaattctct 15540 tgcctcagcc tcctgagtag ctgggattac aagcacacac caccatgcct ggctaatttt 15600 ttttgtattt tagtagagac ggggttttgc catgttggcc aggctggtct cgagctcctg 15660 acctcaggtg atctgcctgc ctcggcctcc caaaatgatt acaggtgtga gccactatgc 15720 cctgccggca actgtaaatc ttaaaacttg caggttctgt ctctctctct ctctgttttt 15780 tttgtttgtt tgttttgggg ggggtccttg ttttgtattt actgaagaaa ccggattatt 15840 gttttgtaga gtttacccaa gtccaaattt tgctgattat gccatgatat ggcttaatat 15900 ttttttctct ttattttcta taaactggta gcgagagctg gaagcttgcc ttgatgaggt 15960 tagggttggt tattcttggc aagataactc tagagatgag ggtgtttttc cgtcaggagg 16020 cacttgacat ctggttgact cctgttgttt ttggctgcta ttgatgctca ttggccagat 16080 ctgtccattt tctagggagc tacaaaatgc tgatatttta attctattac ttcttgcatt 16140 agctgaaata gatctttaaa aagaaacttt tcctcctcta ctatttagtt accaaatagg 16200 cagaataaat gctttatctt tccttttatt taccagtttc cagaataaca agctggttcc 16260 gtagcattct ttaccagtga ccaacagagc atacattgaa aatttttaca gtgaggatag 16320 agcctatcaa tagaagctgt catggagttg aatagggtca tggggcttgc agacatttgg 16380 aacagtgttt cccaaacttc cttgaccaca gagtccttta aaacgtataa gacattcccc 16440 cagaggagca caagagcaga gactaaagga actccatcca catctctcca tttctctgtt 16500 gtcctctccc attctctcgt cacaatccct tctctccctt cccacctcac ttccccatcc 16560 ccctcctcac ccctacaact cttcagccat ttgctctgga aagggtcaaa actaaacagc 16620 ccatcttgaa ctgaccttgg ttccctcctc attgagttct aattaattat ctctggccag 16680 gatttaagtc aatagccaat taaaagttta ttctcatgac attattaaaa tttgatcctg 16740 aagttttaat ttttccattt taaagatagg attgcagttt ttaaggactg ggaaaaaaaa 16800 gttctcatat gtgctgcata ttagtgcttt acattcttca cattattttc tcaaagggtt 16860 tatgattgag aacttattta gtagataccg gggcagggta ccaaccatga ccacctcatc 16920 tgattgagca cattggctaa atctaaacta ataagtattc aactttacat atgatcatta 16980 ttttacttcc ccaaattcct ttgcagatga gacaaacaga tcgggatgta ataacagcat 17040 taactcacag accttggagc ctaagccata caggagatgg gaaaccacgc tatgatactt 17100 tctggaaaca ttttatattt gttatgatgg acattttgct cgattggagc atgcataata 17160 tcttgtggta cctgtgtgga atttcagctt tcctcatgca aaaggatttt gtatccccgt 17220 aagttggaag gttttttatt ttacccagac agacatcctg aatgctctta tttgaaagga 17280 aggattaaca gagtagacaa cctgaattgg ttctgacctg caaagcttac catacctcta 17340 aattggatta ccaatttcgc ttcttaggtg ggaagagttc aggcatattt cactgttttc 17400 agaccgagtc gatcacatat tttcggtttt ttagtgtatt ttgaagaaaa aaaatgaacc 17460 tgtgacacta tgctgagcaa gggattttat ttctgtgact gttttttg aaagccaaca 17520 caggatcctg ggcagaacca cagtgaagac atcctgtggg caccagccctc cccactaccg 17580 tcttatgtta taggcactcc cccacctc cccataaaat ttccattcc taacctgcta 17640 gcgatctcgg aatcatttct ttggcaattc tgtatctgta tatttcagct aattagagtt 17700 gtaggtctag tattattca gatacatg attcagttca attaatattt ggtaagtgcc 17760 tatactattg caggttcca tgttgagaag ctgagatgc agtgggtaaa gatcaagc 17820 catgatctct gccctcgtga cgtttatagc caagtgggag agtgagagat gctaatcaa 17880 taaaaatcca atcaataa agttaaact aagatacagg ctatgtcaga gaaaactgtg 17940 catgggctat aatctaatct ggtctgggtt gtcagaaaca gcatccccaa ggaagtgaca 18000 gttaagctaa gatctgaagg gtgagtggga attgggagga atccagatca gagaaaaa 18060 tacatgtaat gtgctctggc aggaggaac atggttcttt ccaggaagtg aaagaaaatt 18120 aatattcttt caattaattt aaaattaatc agcacagaaa agaaaggg aatgtggtgt 18180 gagatgaagc caaggaca ggtcggggcc aggtcaggca caccttcagt ggctgtgcca 18240 aggacatttg ggggtggcga tcattagtga gctactgaaa tgttttaagc tgggacagtg 18300 tagaggggt tcatggcatc ctgggttttg gaacagtccc tctgatcaca gtgcagaggc 18360 cagttaggag gcattctctg ggcaccattg gtatgcagtg aacaccatac ttagtggcca 18420 ttatggattc ctgagacagc tgcttattat tctaacagga ttggctttcc tctttcccca 18480 gggcctactt gaagaagtgg tcagctaaag gaatccaggt tgttggttgg actgttaata 18540 cctttgatga aaagagttac tacgaatccc atcttggttc cagctatatc actgacagca 18600 18660 actgccaggg gcctcataca gggatatcaa aatacccttt gtgctagccc aggccctggg 18720 gaatcaggtg actcacacaa atgcaatagt tggtcactgc atttttacct gaaccaaagc 18780 taaacccggt gttgccacca tgcaccatgg catgccagag ttcaacactg ttgctcttga 18840 aaatctgggt ctgaaaaaac gcacaagagc ccctgccctg ccctagctga ggcacacagg 18900 18960 catgggacat gcatgataac tcagagttga cattttaaaa cttgccacac ttattcaaa 19020 tatttgtact cagctatgtt aacatgtact gtagacatca aacttgtggc catactaata 19080 aaattattaa aaggagcact aaaggaaaac tgtgtgccaa gcatcatatc ctaaggcata 19140 cggaatttgg ggaagccacc atgcaatcca gtgaggcttc agtgtacagc aaccaaaatg 19200 gtagggaggt cttgaagcca atgagggatt tatagcatct tgatagaga gctgcaaacc 19260 accaggggc agagttgcat ttttccaggc tttttaggaa gctctgcaac agatgtgatc 19320 tgatcatagg caattagaac tggaagaaac ttccaaaaat atctaggttt gtcctcattt 19380 tacaaatgag gaactaaac tctgtggaag ggaaggggtt gcctcaaaag tcacagctta 19440 gctgggcaca gtggctcatg ccgataatcc cagcaattca gaaagctgag gcaggagat 19500 tacttgaggc cagactgggc aatatagcaa gaccccatct ctaaaaaatt aggcatggtg 19560 gtgcatgcct gtattcccag ctactcagga ggttgaggtg ggaggatcac ttgagcccag 19620 aagttcaagg ctgcaatgag ccatgattac accacggcac tacaaccttg gtggcacagt 19680 gagaacctga ctcttaaaaa aaaaaaaaa aaaaaaaaa aaaagataac tagaacttct 19740 agaacatctt gtttacagtt agccagaaac tatacaagtg gtttaacatg cattatctta 19800 ctcaatccat acaaaagtct tatggaggtg ttagcactct ttctactgat gaagaactga 19860 ggtacttcat aaaaccactt acccaaggtg tcttgagtct ggtacaactg gcattcaaat 19920 ctaggtcagt ctgcccccag agccactacc cttacccctc actgaatctg cctttatatt 19980 gttgagccca tgaccccaaa ctgctctttc caatttgaac ttccagggat tttattgtga 20040 acttacatag caacattaaa atgaagttga attgttttta atggcaacgc cgtctgtctc 20100 ctctagctta ccgcttctca cctttcaacc ccatctgtgg cctttgtcca ggcccacagc 20160 ttagccatgg cttccctcct gcatccctgc cgtgggttgc tggcctcaca cttgcagcag 20220 ctggacagtg attttagaag gccaccagtc cccatagcta tgtgacaatg agaagcaaac ttttttgtga cagattgtat tggcataggc atgatagtg gggattggta cgttttgaat cagcatttgc aaaaaattg tcttgaattt taaataaac aacaaagatt tgttcattga gtgcaa 20406 <210> 6 <211> 48569 <212> DNA <213> Man(Homo sapiens) <400> 6 60. gcactccact gaccgtcccg acgatgctac gcgcgcccgg ctgcctcctc cggacctccg tagcgcctgc cgcggccctg gctgcggcgc tgctctcgtc gcttgcgcgc tgctctctc 120 tagagccgag ggacccggtg gcctcgtcgc tcagccccta tttcggcacc aagactcgct 180 acgaggatgt caaccccgtg ctattgtcgg gccccgaggc tccgtggcgg gaccctgagc 240 tgctggaggg gacctgcacc ccggtgcagc tggtcgccct cattcgccac ggcacccgct 300 accccacggt caaacagatc cgcaagctga ggcagctgca cgggttgctg caggcccgcg 360 ggtccaggga tggcggggct hold gcagccgcga cctgggtgca gcgctggccg 420 actggccttt gtggtacgcg gactggatgg acgggcagct ggacggcagg 480 atatgcgaca gctggcgctg cgtctggcct cgctcttccc ggcccttttc agccgtgaga 540 actacggccg cctgcggctc atcaccagtt ccaagcaccg ctgcatggat agcagcgccg 600 ccttcctgca ggggctgtgg cagcactacc accctggctt gccgccgccg gacgtcgcag 660 gtgacccccc gggcggcccc tgtgctgtcc cggtcctccc acccgccctg gatgctctcc 720 cgcctccccc agaccctggg cttttccgat gccccccagt tctctttcct cttttcccaa 780 gccatcatcc ctcgggctac gtcctccctg tcgagggata ttacagactt ggctatctct 840 ttttcccctt acacgtatgt tcatttatta attcatcagg tgtaaattca gcaccttgta 900 ctcgctgcct gctttagtag agttggggat ccaacaggaa agggacaga cgaggtctcc 960 cgcaattttt gcgctcccgt tcccaaactg aattgcccct tcgagcgcca acccatccct tccccttcc ctggcgtcta gtttcacaat tgggcgcacg ttttaaaaaa cagaatctag aattttcttc ctcgggcttt gcttccgata ctagtttttc cttctttctt tttttttttt 1140 tttaaactca tcatctttt cagatgacag tttagacct acaccctgtt ttaggaacct 1200 gatctcaagc ctttgtgtcc tccttttttc ttctgttttg ttcatgtttt tactgtagcg 1260 ttcccatcgt tgtagctgtg gtccgtggtc acaagcagta acaactcatt tattccatta 1320 attacacttt ttcgaaattt gagaaatcat ctagtaaggc cccgttattt cacaggtgaa 1380 gaacccgagc ccaagagtat gcctttttaa ttgtctttct ctaaggtcta gtatccaagt 1440 cttctgtttt cctagaatgg ttctttttct cttagaaaat gttgtaatag ttacaaataa 1500 taatgatagc atacacctca tgcctattgt atgccaggta tgcctcacat ttattttaca 1560 aaatccttac aaccacaatc tggagttgat agtattttcc ccttatctca aagatgagga 1620 aattgataca cgaacacatt aaataatttg cccattttca tacagctagc tgtggaccca 1680 ggaaatctga ttcagagctt gctttcttag ccattatgct atactgcctc catttgtcca 1740 ataacatacc taataagaat aaaaacatgt aacatttttg taccacagag atgagcaagc 1800 attaatagtt tcttgatcac ttttaaggcc agaattgaag tgaggattat tgtttagctt 1860 caaagcccaa gtgaaaaatt agaagtaggc tggtttgta tttctctgt agctgttgaa 1920 cagtgaaacc atctgtagg gatttctcca ctgattctgt gtcatgttat tgtgggtaat 1980 tcagttagct gacttgtgtc taattactg tgaactgtg tttttttta atatatact 2040 ttttccatta gcatgagtga aaattcctca taaatctgtt aattacag aatggtgaaa 2100 gcagaacata ttttaata acacaatc tatagcgact tcctggaaca agtgaatttt 2160 tgttctcaga tggcattgcg aagactggca tttgactctc agtacagagc cagggatgaa 2220 atactacag ttcagaataa gccactcct gaccgttttc agtgtcagat agcaaccct 2280 ttgcctagcc actttattat tctctataga caatagtttt gcctattatg tacatctggt 2340 cttttgagggg agtctgctga attagatttg tagttttgta gaacagaac aatgcctttg 2400 tttttgtttta aagactagca atattagat agtaacagg aaaatacc cagatgcact 2460 tgggaaatta tattttagtg tacacagaaa aaggtgaca aagttcgctt attttcctag 2520 tcaagatatt ttcttaagaa ttgcaatcca gttgacaag tgggcagaat tatccattc 2580 aagagaaaca aacatacata ctgatttt ttgcatacac atccaagcc cagataaaac 2640 tatattcaat tttctcatat tttagtaca aaaatgatat acttggtgtt cttttcgtgg 2700 taaattgttg gagaatgat tgaaaatgt gtgttttgaa tatgactga aaaaacgtaa 2760 agggcacacc agtagttgaa gcatgattat gatgcttct ccaatacata ttgttgccc 2820 aattgggggc ataatgtaat ttattaatt ttatatagaa agttatctgg ggcttcagtt 2880 aaaagataaa ccaattcaca ggcccagcac agtgagcac aggagaccca aaacatcagt 2940 gcgttttgtg ctgctgtcag tagttttttgt ccaagcaga atctttgtaa agtaatacag 3000 agttgggaag gttaattgag aaaaaaat actctgttta gactttggct taggtgaaa 3060 aaatagattc catatgttga attctctctc accttgtaag tagaacttt gctgattttt 3120 agtttgcttt ctaaagtttt ccgtgcctga cagaaacagt acttattaat gtatgatgca 3180 atttcattgc gtagcatctc tacacacat ttaatctca atctctattt ctttagcctt 3240 ttctagctat tctcatgcgt tacagccatt ataaatgggg ataatttta cccaagagt 3300 ttcctgacca atatgtgctt atttcagctg tgcggattag taagatgtta gtgttccttt 3360 ttcacactta acattttcaa taatttgaaa ctgtcattta tgtcagtgat ttacaaatac 3420 atataaattt ttttctcttt cagatatgga gtttggacct ccaacagtta atgataaact 3480 aatgagattt tttgatcact gtgagaagtt tttaactgaa gtagaaaaaa atgctacagc 3540 tctttatcac gtggaagcct tcaaaactgg accagaaatg cagaacattt taaaaaaagt 3600 tgcagctact ttgcaagtgc ftaaatga tttaaatgca ggtaatatgt ctgttgtctt 3660 ttatttgaac ttaacagttt aaataatttt gaactgtgaa aatgaaaaca taaggaaaca 3720 gtctttttta aagaccata attgatctac attaagaaaa taatatgttc tgggtcaaaa 3780 aaattgtata ccttgtgctt actatttacc atttttagat tcatattctt ctttgagtgt 3840 tatttaaatt actgtacaag attctagtta tattctggag tttttttgag ggcagagtaa 3900 tataaagcct caactgtagg cattattttt aaaacaaatt atcttttctg aatttccccc 3960 tgataaagtg atacaaatgg aaaaatcata taaattcttt agcttttgaa gcagttcaaa 4020 agtacctgtt aatgtgtaag aggggtaagt tttagaaagt gaaagcaa gtactatgat 4080 gtttttgag ttatagtag caatgctgag aagatgagca gtcatgtcta tcataagtta 4140 ttgcagtgga tgggctgact atgcaactta ccatccaac tggtgggaca ctttcgaaag 4200 tgaaagggaa cactattaat aattgcca ggaaagcagg tgggaacca tggcacatgg 4260 tcacctagca atgggatt aagaaaataa gatttttttc tgttttctag gatttatgt 4320 tccatagggt agatgttgac aagatacat gcaagattg tagattacat tatactctga 4380 attaatttcc aaagactgg aagtagatgt tgggaaaa atagattaga atttatcagt 4440 cacaggggcct ggatgcttta taaggatca aaagagatg cctagactag catttgaat 4500 tgaattttt ctctctcc aaactggcag tacattggca tcgcctgtgg agctttaaaa 4560 attatttact ttattgggaa atattcaa cacgagata aaaaaagg ctaatgtggt 4620 gaacatccct atacccacaa cttggtttta ctaaatttta actttgtgct tcagttactt 4680 gccttaaata aattgaggtc tactgtccc ttcctggat cccattctc ttccttctc 4740 accagtgta attgttgtca tgaattgagc attatatta tcccatgcca gttttataca 4800 taaatgggat attgttttgc agattttaa acttttaaga gtggtatcaa agtttatacc 4860 agtccaaaat tctatttt tgcaactttt tgttttgat gtaatgtttg caatctct 4920 cctacatttt aaatgtatgt atttcattct acacctatac caatctag ccattattct 4980 gttagtaggc agttaggttg tgaaaaga tttttaaaa ctagtttag tctctgaatg 5040 ggcaagaattt atgtatttta ctgatgaagt aactgacagc aacttcttt tggagcagt 5100 attaagtata gtggttaaaa taatggattc tggaattgga ctatttgcat ttgaatcttg 5160 acttactat cctattgaat aactatgatt tttgacaagt ttattaatgt ctttatgcca 5220 cagttttcctt ttctgtaaaa tgaacatggg aattattctt gtcttatagg attattgcaa 5280 agattatata agattaatttc atacaaagca tttagtacct ggcgcagtaa ttgcgcaata 5340 atactttg ctatttaaat acccttttgt ttacataggg ggtgatgcta tatgtatttt 5400 cagtaactta ctatttttac ttaacaat atttgtctct agacaatat agaactgtct 5460 cattctttta aatcctgtgt tatttcatgg gatatgaa tgactcgatt tgtaagtca 5520 tgctagttaa attgtttaac ccatcatcga attttactgc tgtaagaggc tgttgctaat 5580 gcagtccaaa ttctttt agaaaccatt ttcctactga agttttctt agttttaac 5640 tctttcaggt atgctacag tgacattct tgtagtctgt tttcact tgagagttta 5700 tttgtaagat aaataggtg aggccgagtg ccgtggcata acctataatc ccagcacttt 5760 gggaggccaa ggtgggtgga tcactggagc ccaggagttc agaccagcc ttggcacat 5820 ggtgaaaccc tgcctctatc aagacacaa aagttagcca gtcttataac ttggtctcca 5880 aaaaaat tagattctta aaatgtttt ttaagataa ataggtgaa ttgctgggtt 5940 aacacacatg atattttac atcttgacat atatttttaa attgttctct gaaggtgtag 6000 taaaaattta tatccacagt atatgagaat gttcattttc ccatactctc cacagtaga 6060 tattattagt cattttaatt ttcgccaatt tgattaatga aaatagtat ctagctttaa 6120 tttgcagttc tttgattact tctgaaagtg aacatatttt catgtttagt agccatttgc 6180 atttcttcta aaaattaccc cttcataatt ttgttcattt tctattgggt tatttttgtt 6240 ttcttatgaa tcacaaatac cttttatgta ttatggatat attaattata tcttttaatt 6300 ctgcctgaca aaggattcgc cctttgcttg ttgtatgttg ctaatatttt aatttcttgc 6360 ttatctctta ggtttgttga tggtgccttt gattgcacag aagtttacat cttttacata 6420 gccatatctg tctcttcatt atggcttctg agtgttgtat tttgtctagg aatcctccca 6480 ccgcaagatt attatgtttt cctattgtct tccttttttg ttgttttatt tttttctcag 6540 gggagtggag ggaaagggtc tatttcgttt tttaaatatt taaatttctt atccacctga 6600 aatatttttg aggttctgaa agattgacca cgaaatcaga agggtcataa cagataagtc 6660 agagctataa cttaaataag atagtgtatc taacctcttt actttgtaag tggggaaatt 6720 gacactaaag agagcttacc caggataatt agtggtaaag tcaggtctca gcctgtcttc 6780 atctgatgct ttttctccct gtactctgaa gagttttttg gtgaattttt tttttctggt 6840 aaactctctt ccggtttaag aatataccat gtggactgac ttcatagttt cagaattaga 6900 gcttcgagtg taaataagcc aggtcctttc atcaaatgta cctggtactt acaagccact 6960 atattgtatc aggtattgag attataaaac cttttcttta cgtaagcaaa gttttgaatg 7020 gctttctgt atattcccaa tgaaatacat ttttttgta ttatatactg cctcaggaat 7080 tctttaaact cagaactagt gcaaaatgca tgtaacgcca gttgattttt ggtcccattt 7140 tcctttagga aaacaggaaa ggcagtaaaa ttaaagaaaa atcaaagcaa tggaggcaac 7200 cactgcagtt gacttttttt tctctctagc attaaatatc acccacttct cattgactag 7260 agagcagcag tgtttttatt tactaacaaa ggctactttt tatagcccaa gcattcattc 7320 ccttatcact tctcttcaat acccatatgt atctcaaagt aatgtaatca gcaaattagc 7380 agtgtaaaaa tgctagataa cttattctga aatccacttc cgaaatcatt tgagcagcta 7440 agtttgaaaa actcatgttg gtaccaacat ttctctcttt agtgtgtgat ttttcccttt 7500 ttgtgcttct cctccttggc tgtctctcct ttctccttc ccctcactta cttgcactt 7560 ccttccctct ccatctctgt agcttctct ctccttttat atctttctg tacttactgc 7620 tgcttcttag ttaaaatg aattgtataa tttaaactgt ttaataaatg tactttgtta 7680 tttgtaattt tcaagtcggg tactaaaacc tttataacct tagccccct ccttgaaccc 7740 tctaaaatta acaaaatcat attaagtttt atatagcaag tccttgggtt atactttg 7800 ttgatattgc taggcaata tgctcttaac aagtaattgc ctgaggcagg aggattgctt 7860 gagcccagga atccgagtttt gcagtgagct gtgatcacca ctgcactcta gcctggacaa 7920 cagagcaaga ccctgtccaa aaaaaaaagg cagaaaaag ttaccatta cagaaaattt 7980 cttagtttta ttgggctgaa atttatactt cctcatggtt tctcctgat agttcagttc 8040 tgcaccctta atacacag agaaagtctc ttaatcttt gatagccagg agaaactaa 8100 attatttctt ccccaaactg aagatgtcca ttttattgag ctgtaccaca catggcattc 8160 tacagatatt tagcctttga aaaattgcag aaaataatga cccacaaat tttacctttt 8220 tttcccccca gatttaattc aagtagcctt ttcacctgt tcattgacc tggcaattaa 8280 aggtgttaaa tctccttggt gtgatgtttt tgacatagat gatgcaagg tagtattat 8340 ttttgcagtt tctttgcttt tttaaaaaaa ttttttttgg cttgcttgtt tgcatttggt 8400 tacttgaagc agcttttcag aaaatgagta gttagggaac ataaactgtt ttgtgactaa 8460 ctcctaattt tccttaaata aagagagatt aaaggttcaa attggtccca cctacttgta 8520 aattagtttag gttcaaaaaa ctctggaaac atttttcca tgatgatttg atttctaaat 8580 catcccattt acagacctac ttttaaccca tcatcaaatt ttactgcttg gaagggatta 8640 tagagctgat ataatcccag attcttttta tgggaagcca aagctcagag agaataaatg 8700 ggttccaaa gtcctagcaa ctattttata acagttttca tgggaaattg tgttctgtgt 8760 tttacagtga acacttgtat gtccttcacc tatatttacc agttaacctt ttttgccaca 8820 tttcctttat cactctctct actatattag tttcctattg gtgctctaac aagttaccac 8880 aaacttactg gcttaaaaca atataagttt attatcttat ggttctggag gtcagaagtt 8940 caaattgaat cttacagggc tgaaatcaag gtatcaatag agccgtatac aatagagccg 9000 tattctttca gggggcttta ggagaacatc tgtaccctgc tttttctgat ctccagaggc 9060 tgcttgcatt tcctatcact cagacttctg acgggtacat ctccagctct aactgtcctt 9120 cctgcctgcc tctcgtaagg atacttgttg attacactgg gcccacctag atagtccagg 9180 atttatctct ccatctcgag attcataagt taatcacact ggcagattcc cttttatcag 9240 gtaaggtaac atattcatag gatgtcaggg attagaatgt ggacatatgg gagctgtttt 9300 ttctgtctac cgtgtgtata taatcttttt ttccccgccc caccatcagg atgcttcacc 9360 cttaaatact tgggcatgca tctaggacaa gaacattctt ttgtataacc acaatacaga 9420 atactatagt tcatatttat gtatatcata tatatcacaa tattttctaa tgtacagtca 9480 actttcaaat tttcacgtct taagtctttt atagctgttt tttgtttgct ttgttttata 9540 agattcagga tctaataagg gatcattcat tgcatttggt tgcatttctt ttagtctcgt 9600 ttaacctgaa agagtgctcc agcctttctt ttgtccttcg tacattggcg ttttggaaga 9660 gtctaggcca ggttttttgc agaatgtttt tggatgtgtc tgatattttt tactcaggat 9720 tagattcaga ttaaacattt ttgacaagag cactacgtaa gtgatatatc cttctcagtg 9780 catcatatca gaaggactga tgtctgcttg tcatgtcatt gattattatt actatttttt 9840 tgagacagtg tctctctctg ttgcccaggc tggagtgcag tggcgcaatc tcagctaact 9900 gaaacctctg cctcccggat tcaagtgatt ttcctgcctc agcctctcca gtagctggga 9960 ttacaggcgt gtgctaccat gcccaggtaa tttttttatt tttagtagag atggggtttc 10020 accatgttag ccaggctgat cttgaactcc tgaccttagg tgatctgccc gcctgggccc 10080 cccaaagtgc tggtattaca ggcatcagcc accactcctg gccagtgatg tttgatcatt 10140 agattacaat ggtgcctgcc tgatttcttt attgtagagg tacttttttt ccttgtaaat 10200 aaagaacttc ttggccgggc gtggtggttc atgcctgtaa tcccagcact ttgggcggcc 10260 aaggcgggtg gatcacctga ggttaggagt tcgagaccag cctggccaat gtggtgaaac 10320 cccgtccata ctaaaaatta aaaaattagc caagcgtggt ggtgcacacc tgtgatccca 10380 gctactcggg aggctgaagc aggagaatcg cttgaaccca ggaggtggag gttgcagtga 10440 gccaagattg tgccactgca ttccagcctg ggcaacaaag caagactctg tctcagaaaa 10500 aaaaggaaa aaggaaaaaa aagaacttct aatttaaatg actgtgactt gaaaatttaa 10560 atacatgttt attaaattaa ttgaataata gtttcttttt acatgtgaaa agaaattaaa 10620 ttcttcttt aaaattaag gttgtcttttt gattgaggta ttttctatta tttacttcag 10680 caatttgtta gaaaatatt tatccctgct taggactttc actgtgaaat aggtttatat 10740 gctgaagtat ttacaggtga aataaaatga tacctgggat ttgcttcaaa ataatacagt 10800 ggtggtggta ggagcaaagc tgaaatggga ttggttgaat gttgattatt gttgaagttg 10860 gatgagtaca cagaggttcg ttatactact gttttatatt ttttatgtgt ttaaagttct 10920 ttgttaagaa tttttttttt tttttttt ttttgacaca gagtcttcct ctgtcgccca 10980 ggctggagtg cagtggccca atctcagctc actgcaacct ctgcctcttg cgttcaagca 11040 gtcctcctgc ctcagcctcc ccagtagctg ggattacagg catgtgccat catgcccggc 11100 taatgtttgt atttttagta gagacggggt ttcaccatgt tggccaggct ggtctcgaac 11160 tcctgaactc aagtgatccg cccgcctcac cctcccaag tgctgggttt acaggtgtga 11220 gccaccgcac ctggccaaga atgtttttta cattaaaaa ttatagaca tttatgaat 11280 tctgagataa ttagatatcc tggacttgt gtaccttcag caagcatttt ttgagtttcc 11340 gttctgtgac aagcacttgc ttggaactaa agacactaac ataagataga tattgtccctc 11400 aaagaatgcc aaggaatg aagacatgt aactaaacca ttgcaagaca ataggatgtc 11460 tatacagtga tagagtata ctcagatgct ccttaagtta tggtggggtt gcatccagat 11520 aaacccatgg taggattgaat atcttaagtt ggagtacat tacgactta caatggattt 11580 atccacacat agcctcgttg taagtcagg agcgcactga aagtgtattg ctttgaacc 11640 attgtaagt tgaaaaattt tagtcaac catcataagt tgcagactgc ccatgaaagg 11700 tgtagtgggg cacaaggag aaagttaatt tgtaggatag ctttttgca atttgtgtct 11760 gctttaataa gtatatctag attttctc tcctgggatt agttttggta ttatatatac 11820 ctataaaagt catttatgtt atccattatt tgctgaatta agcaatata tcttttgatt 11880 ttaaaaagtg ttttccttct ctgaaattat ttctccgtaa ttgtgtattt ttgctttcaa 11940 ttttttcttt attacagtag tttattgttt actaatttat ttttcccta agaaacagtt 12000 tagctttatc tgtttttgaa ctttataatg atggaattac tcagcgtgtg ttttttttct 12060 tttggtatct agctcttgtt caacattaag ttttaagat ttatttggga gctaaatggt 12120 gagaacacat ggacagatag aggggaacaa catacactgg ggcctttcag agggcagagg 12180 atgggaagag agagaggatc aggaaaaata actaatgggc actaggatta ataactgggt 12240 aatgaagtaa tccatacaac aaactcccac gacacaagtt aaaaaaaag cttcccattt 12300 atagattgct acttagaagg cagggatttg aactgggagg aattaaaat gatcttgacc 12360 tgttgtgttg tgaaaaggtt tacaaatttc aggaaaatat acctcttctc aaatggattg 12420 ggaattatga ggtcacagac atttctcagg attccgtaaa acatgtacct gtagcagagt 12480 attagaggag attgaagcaa aggggcaagc ggtaacttct tgggggcgat taagtcattg 12540 tattatcatg gtgggggcag gttatacagt tgtttatatt tgtcgaaagt catcagcctg 12600 tatatttaaa tcatgtgtat gtaaattaca atttaataaa gttttaaaaa tgaaaaaaga 12660 tttatgaggt tgcatatagc tacaattttt aattttcatt actgtataat attccattat 12720 atgaatattt tacagtttat tcattatctt ttcagtagac attgttttta gtttggggct 12780 attatgaacc ttgttgctat gaacattatt gtatatgttt attggggtac aggtatacct 12840 gtttctgaag gtgtatgtct ggtagaatta tcgattctca tgcttcagcc tcctgagtag 12900 ctgggaccac aggcatccgc caccacacct ggctaatttt tgtattttta gtagagacgg 12960 ggttttgcca tgttggccag gctggtcttg aactcttgac ctcaagggag ccacttgcct 13020 cagcctccca aactgttggg attacaggtg tgagccactg cacctggcct tttttttttt 13080 tttttgagac agagtcttgc tctgtcaccc aggctggagt acagaggcgt gatctcggct 13140 cactgcaagc tccacctccc gggttcaagc cattctgctg cctcagcctc ccgagcagct 13200 gggattacag gcacccgcca ccacacccgg ctaatttttt gtgtttttag tagagacggg 13260 gtttcaccct gttagccagg atggtctcga tctcctgacc tcgcaatccg cctgtctcag 13320 cctcccaaag tgctgggatt acaggcgtga gccaccgcac ccggcccttt ttttttta 13380 atataagt tttagtgta agcatgtgag aattttaa atctccagtt gcctcctttt 13440 tatttctaat agtagatttt attatttga taggattgaac agactattat ctattcctt 13500 tttaaatttc ttagtgttta cgtctctttg ttaacttct gatttcattg cctttgtgta 13560 aggacagact ctctcaagcc gtgtttcc tttactca caccaccatc acatcatca 13620 accagaga cttctgtgac caatgtgtg ggagccttc ccctgcacgc caagcaggag 13680 acaccagctg gtgtcctcc agttcagat tgacattgtc tacctggagg tagtattaga 13740 13800 ttcaagttgg cgttcccatg acctctctt tgggttcagt taatttgctg tagcagctca 13860 cagaactcaa ggaacactt tgctggttt attataaagg atgttacaa ggatacagat 13920 gaagagatga gtagggcgag atatggggga agggcgtgg agcttccatg tcctccctgg 13980. gcatgccacc ctccaggaag ctccacatgt tcagctatct gtaagctctc taaacccagt cctcttgggt tttatggaa gtattccttc cccccaggat atgaggcagg accctttcag ggcaggatct tagccccc agaaaggcag gaggc gttctgcctc cgcacaggtg 14160 aaagggaggc aggagagga ttctgtttcc tgaggcctgc cctggaggcc taacacaccc agcattac caaaagacta caacaggga tatgggagtt acaaaccagg aagtgtggac 14340. 14340. 14340. 14340. 14340. 14340. 14340. 14340 accttacatc aaaagatc attackcatc father gtccatcatc tgtatgaatg tcttccaggg caaggccact caggtttgcc agcttccttt caatcctgtc aggttccaaa accaggagtg gtcttggcaa atttatggct tcaccctttc atgcatctgt catacttgag ctaagagaca gcgtcacctt ttgctctgag ccccgttcaa ggcgttcatg taatatgtca tttccttcaa tttataaccc gtttattcat cctttttccc tcagctgttc tccttttctt cattaataaa tatctacact gctacctttg gaagggacac aagttgccat tgtgctgtgc 14700 tagtctagat tgtaggcagc aatgctagtg tagcaagtag ctcctcctca cccctttaat 14760 gtattttttg ttttgttttt atatatggca ctgacccacc cctgctctta aaacttacta 14820 tgacatgcac tagtttctc taggagctct ttcggggaaga aaggtttgtg actattgtag 14880 tcatcttgaa cctctttgg gttacatatt ttagtcccct agttgtggtt ttagctacag 14940 gttttagttc tagatagaga tttcagttct ccacttctac atgagcaaat gatcaaatga 15000 tatgtaagtg gaaaatttaa ccctcagata aaggctactt aattaccagc tcccggttcc 15060 agacctttca gcagaggtta ataactgtaa tcagtgatag gtaggtttca aaccgttttc 15120 tatactttta taatctgtat cattcttaga aataaaag gtatagtgtg tgtgtgtgtg 15180 tgtgtgttgg tataaatgg tattataggg tatgtattat ttttaatggg ttcttattca 15240 acattgtgtc ttggagattt ttccatgtca gtacatggaa atctataata tagaactttt 15300 tgataactgc aaagtattct gaagtatgtg tataccatag tttatttaac catctaccta 15360 ctattggaat ttagttgttt ctggggattt tttggcttct ataagcagtg ctactataag 15420 tcattcttgt acattctccc tggtgttcct ctgtgaatat cactttataa gaaatggaat 15480 taaatgggtc atagggtatg tgtgttttca tggattttgc caatttgccc tctagaatgt 15540 ctataccaat atacattcct tccaacagta cccatttccc catatccttg gtacactttt 15600 attattt tttcaccaaa cagatacatg aaccaaagta actcatttttc tatttgactt 15660 ctaccttctc aaaattctta tacatttctc atccacctat ggtatctttc tgtgctttaa 15720 tgaatattct tcttcttat tctttcttct aaatgtatcc ttgacattta gaagaaagaa 15780 taaagaagaa tattaatata atatcatctt aatataatgt tagaagaaag gagaggtgag 15840 cacatgtcct tactccactc tcttgagctg tcctgacctt ggatgattgg ctgtgagcac 15900 ttactggctt gctcttgcac accagcatct acattccccc aatccaaatt tgtgatgcag 15960 cataaatctc tctgtggtat gaaccttagg gaccaactct taaatgctgg aaaggacaaa 16020 tactatattt tgtgcagaat ggtaattaaa cattgtaacc atttcttaga gaatcattat 16080 taaatcaggg aatcttgtta tatttttgaa aatattag aaattatttt tgaatttttt 16140 taggtattag aatatttaaa tgatctgaaa caatattgga aaagaggata tgggtatact 16200 attaacagtc gatccagctg caccttgttt caggatatct ttcagcactt ggacaaagca 16260 gttgaacaga aacaaaggta agaactttct aaaaaatgtg aagtacattt tgagttacta 16320 ctaaacttct ggaaattttt ttataatgag taattttaaa aaatagtttt tgcttgtgtt 16380 tttaaaaaat tttaatataa tgtgatacaa aagaattcga taacatatat gtaaattata 16440 aaacatacga accttccact ctacccaaga actagaatat tcataataaa ttgcatttgt 16500 ttacttatgt gttcctcaac tattccattt tcctgcctcc tcttgccctt ccctttcctc 16560 cagaaactat tctttggaat tttgtattgg tcattcctt gcctctttaa aacagtttat 16620 attatgaatg tattggtgcc caaagaatat atttagttt tcttggaatc atactgctta 16680 ttgtcttttg ggacttgctt tgttccccc ctcaacttta tgtttttaat attcaacata 16740 ttattgcata tagctgtagt tcattttcac tgtagtacaa tattcaataa tgtgaatata 16800 ccatctactc ttgtcagtgg gcatttagat agttcctatc ttttgctgtt ataattagtg 16860 taattatgaa ctctatgtgg ctcctgctat gaatgtgcaa aatgtttttg ttttgaaaga 16920 gaaaaagctt ttgttaacat ttataatctt caattaaaaa taatttttca tgacttgaac 16980 cttgataga acctcaattc caggcttgtt tcaaacttct gggctcaagg aatcctctcc 17040 cgttggtctc ccaaagtgtt gggattacag gcatgagcca ctgcacccag ctgagcacag 17100 agaactttgt aggtggtaga agttttccca aactggattg tggtgattac acagacagct 17160 gtatacattt gttaagatat ctaactcttt aattaaaact gatgaatttc atggtagtta 17220 tgcttcagta aaacttaatc tgagtattta acaaaagtgt aaaaaaaac ggaatgaaat 17280 aatttttgg taaaagtgga aaaattttt ttaaagaaga ctccattttt ctgaattagt 17340 aaagtttttt tttacaaggc aacaccaaaa tgcttatgac ataattactg aaaatgtttt 17400 aaaattatta gatcacttcc ctgcattgat gcgcaata ttggaaata attgaatttt 17460 tttattaag gattttacag tgtcatagggg tcattatttt ttaaaacagt ttgagaata 17520 attcatatgt aggcatgtct caatagt gcaagttca ttccagacca ctgcaaaaaa 17580 gtgaatatca caatgaaggg agtcacacaa ttttttggt ttcccggtgc atataaagt 17640 tatgtttata ctataatag tgtgcaatag cattttgtct taaaaaaaa tacatacata 17700 ccttaattta aaatgcttt attactagga aatgcccatg atcatctgag ccttcagaga 17760 gttgtaatct tttgcaggt gaagggtttt gcctcaggtg tgaggctgc tgactgatga 17820 gagtggtggt tgctgaggc tggggtggct gtggcaattt attgtaaag aaataatcaa 17880 tgaggtttgc tgcatcagtt gactttct ttcatgaag atgtctctgt aacacatgat 17940 gccgtttaat aacattttac ccacagtaga acatatttta aaattggagt caatccctc 18000 aaagcctgtc actgctttgt cactgtcaca atccttgtt gtcatttca caatattcat 18060 agtatcttca ccaggcgtag atttcatctc aagaaaccac tttgttcatc cataagaagc 18120 aactcctcag gtgttcaagt ttgatcatga tattgcagta attcagtcac atctttgggc 18180 accacttgta attttcttgc tatttccacc acatctgcag ctacttccta tcatccatga 18240 gggttggaat cagcctcttc caaactcctg gtaatgttga tattttgacc tcctcccatg 18300 aattacaaat attcttaatg gcatctagag tggtgaaacc tttctgggag gtttccagtt 18360 tacattcctc agatccatta aaggcatcac tgtctatgac agctatagcc ttatgacatt 18420 tatttcttaa ataaataata tttctctgtc atatgaaatt tctgtttttt ttttttgaga 18480 cagagtctcg ttctgtcacc caggctggag tgcagtggcg tgatctcggc tcattgcaag 18540 ctccgcctcc tgggttcacg ccattctcct gcctcagcct cccgagtagc tgggactaca 18600 ggcacctgcc accacaccca gctaattttt tttttttttt gtatttttag tagagatggg 18660 gtttcacctt gttagccagg atggtctcga tctcctgacc ttggatccgc ctgcctcggc 18720 ctcccaagaa atttatttct taaataattt atttcttaaa tatttcttaa atttatttct 18780 taattaattt cttaaaattt ataatgaaat caaaattact acttgatcta tgggatgcag 18840 aatagatttt gttttagcag acatgaaaac aacattaatt tccttgtaca tctccatcag 18900 agctcttgga tgaccaagtg tattgtcaat gagcagtaat atttgaaag gaatctttct 18960 ttctgagcag gaggtctcaa tagtaggctt caaagagcca gtaagccatg ctgtgtaaaa 19020 atagatgtgc tgtcatccag gctttgttgt tctatttata gagcacaggc agaatagatt 19080 tagcataatt cttacgggcc ctagaatttt tggaatgacc agtgagtatt ggcttcaact 19140 tacagtcagg agctgcgtta tctgctaaca agagagtcat cctatccttt gaagccagac 19200 attgatgttc tagatggtat cttcttccaa aagaaggctg ttttgtctac attgaaaatc 19260 tgcttagtat agtgaccttc agttatctta gctagatctt ctggatcact tgcagtttct 19320 acatcaggac ttgctgcttc aacttacatt tttgtgttat ggagatagct tttttcctta 19380 aaccccatga gctaacctct gccagcttct aacttttcttt ttgcagctttc cttacctct 19440 agctttcta gattgagga gagttagagc cttgctgtgg attaggcttt ggctaagggg 19500 aatgttgcag ctgttttggat ctctaccag agcactgaaa ctttctcct atcagcaata 19560 acattcttcc actttcttat catccatgtg ttcactggag tagcacttt aatttcctcc 19620 aagaactttt cctttcatt cataacttgg ctaactgacc caagacct agttttttggc 19680 ctgtttcagc ttaggacatg ccttcctcac taagctat catatcttagc tttgagtta 19740 aagtgaaaga tgtgtgagtc ttgcttcat ttgacactt agaggccatt gtaggattat 19800 taattgacgt aatttcagta tattatctca gggaataggg agactggagg agaggaaga 19860 ggatggagaa tggctggtcg gtggagcagt cagaacatat acaattta tcagttaaat 19920 ttaccatctt atagggtgg gttcatggc acccaaac aattacaaaa gtaacataaa 19980 agatcactga tcacagatca ccatacaga tataataatc atagtaataa ttaaaaaac 20040 tttgaaatat tgtgtattac taaaatgtga tacattacta aaatgtgata cattactaaa 20100 atgtgataca caaatgagc acgtgctgtt ggaaaatta cacagatggc cttgcttaac 20160 tcaggattgc cacaaacctt ccatttgtgg caaaatgcag tatctacaaa gcacaataaa 20220 tcaaagcaca agatgaggta atacctgtat catatacagt ttacctactt aaagtgcaca 20280 attcagtgtt ttagtatatt cacagagttg cacaaccatc actactgcaa ctttagaaca 20340 tttcatcgc ctcaaaaaga aactctatat gctgtgcctt agcagtcact ctccattcac 20400 cctcactctg ccatcccctg gcaaccacta atatattttc tgtctgcatg cattggcata 20460 ttctggacat ttcatataaa tggaatgata tatatgtgg ttctttgtga caggctttta 20520 tgattagca tcatattttt aaggttcttc catgttgtac atgtagcagt agcatgtatc 20580 attcttttc atggctgaat aatattcctt tgtattacta tatcatgttt ttgttcatct 20640 tatttcttt ttttcacctt ttttaaagtt atacttcaag ttctagggta catgtgcaca 20700 atgtgcaggt ttgttacata tgtatacatg tgccatgctg gtgtgctgca cccattaact 20760 cgtcatttac gttaggtata tctcctaatg ctatcctttc cccctccccc taccccacga 20820 caggcccacg ccatgacagg tgtgtgatgt cccccatgct gtgtcaagtg ctctcattgt 20880 tcagttccca cctatgagtg aaaacatgca gtgcttggtt ttctgtcctt gcgatagttt 20940 gctcagaatg atggtttcca gcttcatcca tgtgcctaca aaggacatga actcatcctt 21000 ttttatggct gcatagtatt ccatggtgta taagtgccac attttcttaa tccagtctat 21060 cattgatgga catgtgggtt ggttccaagt ctttgctatt gtgaatagtg ccgcaataaa 21120 catacatgtg catgtatctt tatagcagca tgatttataa tcctttgggt atatacccag 21180 taatgggatg gctgggtgaa atggtatttc tagttctaga tccttgagga atcaccacac 21240 tgtcttccac aatggttgaa ctagtttaca gtccaaccaa cagtgtaaaa gtgttctcac 21300 atcctctcca gcacctgttg tttcctgact ttttaatgat tgccattctg actggtgtga 21360 gatggtatct cattgtggtt ttgatttgca tttctctgat ggccagtgat gatgagcatt 21420 ttttcatgtg tctgttggct gcataaatgt cttgttttga gaagtgtctg ttcatatcca 21480 cccacttttt gatggggttg tttgattttt tcttgtaaat ttgtttaagt tctttgtaga 21540 ttctggatat tagccctttg tcagatgggt agattgtaaa aattttctcc cattctgtag 21600 gttgcctgtt cactctgatg gtaggttctt ttgccgtgca gaagctcttt agtttaatta 21660 gatcccattt gtcaattttg gcttttgttg ccattgcttt tggtgtttta atcatgaagt 21720 ccttgcccat gcctatgtcc tgaatagtac tgcctaggtt ttcttctagg gtttttatgg 21780 ttttaagtct aacttttaag tctttaaccc atcttgaatt aatttttgta taaggtgtga 21840 ggaagggatc cagtttcagc tttctacata tggctagcca gttttcccag caccatttat 21900 taaataggga atcctttccc catttcctgt ttttgtcaga tttgtcaaag atcagatggt 21960 tgtagatgtg tggtattatt tctgagggct ctgttctgtt ccattggtct atatctttgt 22020 tttggtacca gtaccatgct gttttggtta ctgtagactt gtagtgtagt ttgaagtcag 22080 gtagcatgat gcctccagct ttgttctttt ggcttaggat tgtcttggca atgtgggctc 22140 ttttttggtt ccatgcgaac tttaaagtag ttttttccaa ttctgtgaaa aaagtcattg 22200 gtagcttaat gaggatggca ttgaatctat acattacctt gggcagtatg accattttca 22260 ctatattgat tcttcctatc catgagcatg gaatgttctt ccatttgttt gtgttctgtt 22320 ttatttcctt gagcagtggt ttgtagttct ccttgaagag gtccttcaca tccctacaat 22380 tgtgaatggg agttcactca tgatttggct ctatgttgag taggagtggt gagagaaggc 22440 atccctgtct tgtgccagtt ttcaaaggga atgcttccag ttttgccca ttcagtatga 22500 tattggttgt gggttgtca taaatagctt ttattatttt gagatatgtc ccatcaatac 22560 ctagtttatt gagagttttt agcatgaagg gctgttgaat tttgtcaaag cccttttctg 22620 catctattga gataatcatg tggttttttc ctttggttct gtttatatga tggattactg 22680 atttattgat ttgcatatat tgaaccagcc ttgcatccca gggatgaagc caacctgatc 22740 atggtggata agctcatcag ggatattggt ctaaaattct ttttttttgt tgtgtctctg 22800 ccaggctttc aggatgatgc tggcctcata aaatgagtta gggaggattc cctctttttc 22860 ttttaactgg aatagtttca gaaggaatgg taccagctcg tctttgtacc tcttgtagaa 22920 tttggctgtg aatccgtctg gtcctggact tttttggtt ggtaggctat taattattgc 22980 ctcaatttca gagcctgcta ttggtctatt cagggattca ccttcttcct ggtttagtct 23040 tgggagggtg tatgtgtcca ggaatttgtc catttcttct agattttcta gtttgtttgc 23100 gtagagatgt ttatactatt ctctgatgat agttatattt ctgtgggatt ggtggtgata 23160 tcccctttat catttttat tgtgtctatt tgattcttct ttcttttctt ctttattagt 23220 cttgctagca gtctatcagt tttgttgatc ttttcaaaaa cccacctcct agattcactg 23280 attttttttg aagggttttt tgtgtctcta tctccttcag ttctgctctg atcttagcta 23340 tatcttgcct tctgctagct tttgaatgtg tttgctcttg tttctctagt tcttttaatt 23400 gtgatgttag ggtgtcaatt ttagatcttt cctgctttct cttgtgggca tttagtgcta 23460 taaatttccc tgtacaccct gctttaaatg tgtcccagag attctggtat gttgtgtctt 23520 tgttctcatt ggtttcaaag aacatcttta tttctgcctt catttcgtta tgtacccagt 23580 agtcattcag gagcagtttg ttcagtttcc atgtagttga gcggttttga gtgagtttct 23640 taatcctgag ttctagtttg attgcactgt ggtctgagag acagtttgtt ataatttcta 23700 ttcttttaca tttgctgagg agtgctttac ttccaactat gtggtcaatt ttggaataag 23760 tgtgatgtgg tgctgagaag aatgtatatt ctgttgattt ggggtggaga gttctgtaga 23820 tgtctattag gtctgcttgg tgcagagctg agttcaattc ctggatatcc ttgttaactt 23880 tctgtttcgt tgatctgtct gatgttgaca gtggggtgtt aaagtctccc gttattattg 23940 tgtgggagtc taagtctctt tgtaggtctc taaggacttg ctttatgaat ctgggtgctc 24000 gtgtattggg tgcatatata tttgggatag ttagctcttc ttgttgaatt gatccctcta 24060 ccgttatgta atggccttct ttgtctcttt tgatctttgc tggtgtaaag tctgttttat 24120 cagagactag gattgcaacc cctgcttttt tttgttttcc atttgcttgg tagatcttcc 24180 accatccctt tattttgagc ctatgtgtgt ctctgcacat gagttgtgtc tcctgaatac 24240 agcacactga tgggtcttga ctctttatcc aatttgccag tctgtgtctt ttaattggag 24300 catttagccc atttacattt aaggttaata ttgttatgtg tgaatttgat cgtgtcatta 24360 tgatgttagc tggttttttg ctaattagtt gatgcagttt cttcctagcc tcgatggtct 24420 ttacaatttg gcttgttttt gcagtggctg gtaccggttg ttcctttcca tgtttagtgc 24480 ttccttcagg agctcttgta aggcaggcct ggtggtgaca aaatctttca gcatttgctt 24540 gtctgtaaag gattttattt ctccttcact tatgaagctt agtttggctg gatatgaaat 24600 tctgggttga aaattcttta agaaggtaga atattggccc ccactctctt ctggcttgta 24660 gagtttctgc caagagatcc actgttagtc tgatgggctt ccctttgtgg gtaacccgac 24720 ctttctctct ggctgccctt aacatttttt ccttcatttc aactttagtg aatctgacaa 24780 ttatgtgtct tggagttgct cttctcaagg agtatctttg tggcgttctc tgtatttcct 24840 gaatttgagt gttggcctgc cttgctaggt tggggaagtt ctcctggata acatcctgaa 24900 tagtgttttc caacttggtt ccattctccc catcactttc aggtacacca gtcagacgta 24960 gatttggtct tttcacatag tcccatattt cttggaggct ttgttcattt ctttttgttc 25020 ttttttctct aaacttctct tctcgcttca tttcattcat ttgatcttca atcactgata 25080 ccctttcttg cacttgattg aatcggctac tgaagcttgt gcatgcatca cttagttctc 25140 gtgccatggt tttcagctcc atcaggtcat ttaaggtctt ctctaggctg tttattctag 25200 ttaaccattc gtctaatctt ttttcaaggt ttttagcttc ttcgtgatgg gttcgaacat 25260 cctcctttag ctcacagaag tttgttatta ccaatcgtct gaagccttct tctctcaact 25320 cgtcaaagtc attctccgtc cagctttgtt ccattgctgg tgaggatctg tgtttctttg 25380 gaggagaaga ggtgctctga tttttagaat cttcagcttt tctgttctgg tttctcccca 25440 tctttgtggt ttcatctacc tttggtcttt gatgatggtg atgtacagat ggggttttgg 25500 tgtggatgtc ctttctgttt gttagttttc cttctaacag tcaggaccct cagcttcagg 25560 tctgctggag tttgctggag gtccactcca gaccctgttt gcctgggtat caccagcgga 25620 ggctgcagaa cagcaaatat tgcagaatgg caaatgttgc tgcctgatcc ttcctctgga 25680 agcttcgtct cagaggggat gggttgtcag tcggccccta ctggggaggtg cccccccagt 25740 taggctactt gggggtcaag gaccctcttg aggaggcagt ctgtccgttc tcagatctca gactccgtgc tgggagaacc agtactctct tcaaagctgt cagacaggga cgtttaagtc tgcagaagtt tctgctgcat tttgttcagc tacgccctgc ccccagaggt ggagtctaca gaggcaggca ggcctccttg agttgcagtg ggctccacac agttcaagct tcctggcggc 25980. tttgtttacc tacccaagcc tcagcaatgg tggacgccct tcccctagcc tcactgctgc cttgcaattc gatttcaggc tgctgtgcta gcagtgagcg aggctctgtg ggcatgggac 26100 cctccgagcc aggcgcagga fatherctcc tggtgtgccg tttgctaaga ccattggaa agtgcagtat tagggga gtgtcctgat tttccaggta ctgtctgtca tggcttcctt 26220 tggctaagaa agggaattcc ctgaccccgt gcgcttccccg ggtgaggcga tgccccgtcc 26280 tgctttgtct catgctccgt gggctacacc cactgtctga caagccctag tgggatgaac ccgctacctc agttggaaat gcagaaatca cctgtcttct gcatggctca cactgggagc 26400 tgtagactgg agctgttctt ggaacctcct cctcatcatc ttgcttattt tcttataatt 26460 tgcttatctc acctacaaat aaattacaga gggaaaaatg caactaattg agcactccat 26520 ttttggtagc tagtagctga tggtatttta ataaactgag aagctaatga ggtgaatttt 26580 catgcatggc ttgtagtagc aggtgcagtt ctgtggtgta gaggcaatat gacatagtag 26640 gcagttgctt ggatttggtt tgactcctgg tcctgcttta tggatgctgc agattcctta 26700 cttggaaaa gaggaatgaa gaatgcctag ccctaatgtg aaaattcaaa atactccaaa 26760 ctccaaaact ttttgagtgc ggatgtgatg cagcaagtca aaaattccac acctgacctc 26820 ctgtgatggg ttgtagttga aacttttaaa attatttaaa atatcgtata aaactacctt 26880 catgctatgt atgtaaggtg tatatggaac ataaatgaat ttcatgtcta gacttgggtc 26940 ccatccccaa gattatatat atgaaaatat ttcaaaatct gaaaaaattt gaaatccaaa 27000 agatttatgg tcacgaacat tttggataag gaatactcaa cctatacctc acctgactca 27060 tggaattgtg ataatcaagt gagataatac ttattaaagc acttagtata atatgatata 27120 cagacatggt attggtatta tatgtgatag ttctctggcc caaacatgtc cttaatgtct 27180 ttttcagata ttcacacacc cttcccctct accacccctg ccccccttgg caattgtcca 27240 aataatgaaa acaagagctt tgtgagactt attcttttca aactttatgg cgtcatttat 27300 taaactaact tccttttcat tgcaagatgg aaaacatttt tacttctttt ggatgattat 27360 gccttgtggc ttgaaaggaa aattcattca acaaagcagc tactatgttt atatgtcagg 27420 cagtgatgac tgaggcaaag tcattgcact gtggctctta cagtcttagag aaaataaaaa 27480 cattttataa aagccatgta taatgatata actgtttatg taagattgtg aaacaatgta 27540 agaagttgaa agagagagtt tgacccttta agacaggaaa tcgttttggc caccgcctct 27600 tgttctaact gaagaaggaa tcaacaaaca ctgctcagca gtgagcgatg atgaagaaac 27660 tggcagatgg tttcctggga ctgggtatct ctgtactaaa agactgatga ggattttaaa 27720 agatgcttat tttgctgaat taagattaaa ccttaaaata ggaaaggaga ataaagtacg 27780 gtttgagact tctgtcaggt ttctctccta aaaacagatt gactagtgct gtgagaagca 27840 cttctaaaga aaatcaatat atgctcagca aggagcaagt aagttgtttt ttgtttgttt 27900 gtttttaact aatggacttt taaaagtaat tttaggttca cagcaaaatt gagtagaaag 27960 tacagagagt tcctacttac tgcttttctc cacacattga cagtcaggca ccagtgtggt 28020 agaataataa gcttttaata gaatgtttat ctttgtgttt ttcctgatct cttctatcaa 28080 aacattagcc tttttttttt ttgtacatga cttaaaatcc tttttttaaa tttggaatta 28140 gagtttataa gtgagtattt tgacatccat attttctgac aaaatgactt tcactttccc 28200 aagttcccag gctatttttg ctttctccat cccaccccta ccccttgtta gaatgttagt 28260 atgtatacag attggttttt tttaatatta acattaaatc agggacattc ttcagtgcca 28320 ctgaattttt ttttcaacat aattttgata gcatggtttt acttcatgga aaaaatggaa 28380 gattgcaaat tgttaaattt tcagttaaat ataaccggcc cttgaaattc agctccttgc 28440 attttattag gaacttgatt tttattttcc tttttgcacc atcactatag taatgggatt 28500 aaagttaaaa ccagcaaatt taagcagata tttctattta agcagatatt tctatttaag 28560 cagctgtgat tagaaaagca gattgaattc actgaagaaa tgaagtatct ccagatttta 28620 ttttactgtc tccttcccca tatatctgtt aatataatct ttttagattc gaggatttca 28680 acaagttact tcatgttttc tcaaagattt attttgggtc tataattact tgcctcgaga 28740 tcttccatt taagttaatt actataaaat attttttact gttactaaat acctcaactc 28800 tcagtgttaa cctttttttt ctaccttttt gttgggtttc aaatcattga tatttttcaga 28860 tttcatagtc tataaggtat ggctttttaa agctgtgtag tcccatattt taacgtaaga 28920 tggcagcatt gagataaatg tgtagtgaca ccaagtgatt ttagttatt ggtcaattag 28980 cccattgtaa caggggaaac ttgctgcttt aaagttctta gaaatgtacg ccaattctag 29040 gtgtttttgc caactttttg aagtcacagt tccatggagt ttagccaggg gtatcaggaa 29100 tctttcagt gctaggaatc tctgtagtgt tgaaagatac tggctaaata tttttttttt 29160 tttttttttt ttttttgga gacagagtct cgctctatcc cccaggctgg agtgcagtga 29220 catcgtctcg gctcactgca acctctacct cccaggttca agtgattctc atgcctcagc 29280 ctcccaagta gctgggatta caggcacctg ccaccatgcc cagctaattt ttatattttt 29340 agtagagaga cagggtttcg ccatgttggc caggctggtc ttgaactcct aacctcaggt 29400 ggtctgcctg ccttggcctc ccacagtgct gggattacag gattacaggg gtgagccaca 29460 gtgcccggcc acatactggc taaatattaa taagtaaaag tttatataac tagcctggct 29520 gtactctgaa ttcatattca aatgtccagc tgccttttga atagacactt tttgactatc 29580 actagattgt aggtctacta agtagttatt cattatttct gcacaattat tttacctttg 29640 tacattttt tttaaaacta ttcttgttga attgtatcca gttttgtaag aatcactctt 29700 aaatctgttg tcatatctat tcttgtcata gttggagagt atacctactc tgtgctgacc 29760 ccaacagtag aaccggaagg caaatcttgt ttcagttact atttaaaaa aagaaacctc 29820 acacacacaa aaccccaca ctttttaata actgttaaat aagtagaata ggctgttttg 29880 tgaagtagta agtgtcctat tttagaata tgctagttga atctggataa ctgtgtcaga 29940 gattctatgg aagaaatgct tctaccacct aagaggttag gaattattt catggctcca 30000 taactaaagg ctcagttcat ttcattcag caagcagtttt ttgagcacat acatgtgtg 30060 gtcacaatgc taggcattgg gatacata acatggataa gaagttatac ccgctacatc 30120 aaggggctc tcagtctagt aaggagatg tcttagaaa gtaatttagt caaagcgaa 30180 aggatgcttg ggaaagtaag tcatctctgc agttcatggt agttggaat ggctctgtg 30240 tggatgtaag atgtaggtg agccttaatc attgacactg tagtgtaatg gatttgcat 30300 tggcatagga ttattaaac tcaatcctt gttcagcgtt tcctaccaa aatttgtca 30360 tctttaaaat tcaggtaata ctcatgtttc aaggtgttga gaagttgag tggattctg 30420 tgttcatgta tgtctgtgta ccacacaat acatgtaaag acacatttat cttttactac 30480 tatgctttac acaattaagt attttattaa ttgttattaa taccatcatg acaatcattc 30540 caggcaaaat ttggctagag aagaataagg aagacatcaa ggagaagaag tattgagcaa 30600 aggcctatgt gggaatgaaa atgtaaaatg cccaagttaa tttgatggtt tgagttagac 30660 agtgttggga aataagctgt tagggtgtta tctatgccag agaaaaacag tatactttac 30720 ctgtcatcta gatgctgatt taaaaatttt cctggcctgg cgtggtggct cagacctgta 30780 atcccagcac tttgggaggc caaggcagga ggatcgcttg agcccaggag tttgagacca 30840 gcctgggcaa caggggtaat ccctacctct acaaaagaaa aaaaaaatta gccaggcgtg 30900 gtggcatgtg cctgtagtcc cagctactca cgaggctgag gtgggaggat cacctgagcc 30960 agggagctcg agtctagggt gagccgtgat catgccactg tactccagct tgggcaacag 31020 agcaagaccc tgtctctaaaa taaataaata aataaattaa gattgttcct atttctgctt 31080 tagttatttg tgttaatttt aaataagttc catgtattct gaggtttaca cttaaacatc 31140 tctctcctta attagaacat agacaagtaa agtctattgt tatttttcaa gaatatttgg 31200 acaaatctat tgaaataaat atacagcgtt ttccaggtta tctttgataa cccactatgt 31260 tcaggttatt tggctggcaa cagaggggtat atacaagat gatgcattg aaattgtctc 31320 siaactcaa gtttagagaa cacttataat agcactaaa cagataaaa aaaattact 31380 gagagagaat taatttgaac tctttggtt ttggtaagg ctttatgagg agtctttgaa 31440 gtaggctacc aagacttttt ctttcactaa tctcagcata tcagctctta gtaattgttt 31500 tgatgtgttt attattaact cgattgaggt attattcatg taaactgtac attattaag 31560 tgtacaattt ggtcagtttt tacatatatata tatacccca tgaaaccatc accataatca 31620 agataaaata catcatcatcatcatcatcatcatcatcatcatcatcccc ccattttcag gtaacactga tacactttct gtcactatac attaagttgt atttctagg 31740 attttatata atggaatcat atgaattttt tttgttgg gctctttca ctcacatag 31800 tgattgtaag attcatctgt gttgctgatg aatctaatag ttcattcctt tttaagacca 31860 agtagtattc tgttacatag atccaccacc atttgttcac cttttgatga acatttggtt attcacagtt ttaaggctat tgcaaataat gcttctgaat atttgtgatc tttgtatgtt atgatttgat ttcttgggaa cctacctaat tagtagt ggttgagtct tagtagtg ttttttcac tttttttttt ttgagacaga gtcttactct gttggccagg ctagagtgca gcggcacgat cttggctcac ttcagcctct gtctcgtggg ctcaagcagt tctcctggct 32160 cagcctccca agaagctggg attackcaggca tgtgccacca cgcccagata atttttgtat ttttagtag gatggggttt catcatgttg gccagactgg tctcgaactc ctgacctcag ataatccacc cacctcagcc tcccaaagtg ctgggattac aggcatgagc caccgtgccc ggccgtcttt ttcacttttt aagaaactgc caaacttttc ccaccaatgt atgagagttt cagttgttcc acatcctgcc aacgcttcat atggcaggtc tttttaattt taaccattct aatgggtgtg tagtagtact ttgttgtggt tttagtttgc attttcataa tgattagtga 32520. 32580. cttgagcat cttttcatgt gcttatttac atctatatat ctagtttggt gaagtcttta ttttgtgtgc ttttaattg ggttatcttt attactgttt gtgtgtgtgt gtgtgtgtgt 32640 gtgtgtgtgt gtgtgtgttg tctaggtaca agtcctttgt cagatttatg cctatagga 32700 atatatctc tagtctatg gtttgccttt cttaaaaaat atatatatat taatggactg 32760 atttgcccc attattgagg catttcaccc tgagtattta tatgtaccct gtgtattttg 32820 aggttttccc actctggctt atgtgaaaac tattctgttt ttttgtgtta gctttgggaa 32880 ttttttttct ttttttagac ggggtctcac tctgttaccc aggccagaga acagtggtgc 32940 gatcatagct cactacagcc tcaacctccc aggctcaggc aatcctccca cctcagcttc 33000 ccaagtagct gcgactacat gcatatacca ccatgcctgg ctaatcctta aaaaattttt 33060 aatacatgga acttattttt atttatttat ttatttttat ttttttctca ctgtgttgcc 33120 caggctggtc tcctggtggg ctcaagcagt cttcccctc tgcttctgga gtcactggga 33180 ttatagatag gagtaatctg taattagctc tgctaattttt tttttttttt ttacctattc 33240 cttttcaatg ttttttctcc gggatttgga tagttttctc atacgcatgt gctgttcagt 33300 gccagctgaa aatttgaggg agcccctgct ggtctgcagc actctcttct caggtactcc 33360 tgctgtgaat tcagccagtg tgcctccct aaattctcac tcccatctca gctgctcagg 33420 gcgacttccc gagctgtttg ggcatcccct ccctgtgcca tagtctggaa actcggcagt 33480 aagctggggc agttgttgga gtcacctcct ttgccttcct tttcttataa ctattgttga 33540 gtgtctgaaa ctttgtatgt tttgttcagc tttctggtac tttaaggtag gacagtaaat 33600 ctggtcccta ttactccgtc ttgactggaa gtggaaactg ttcagtgta ttttgcttg 33660 aggaagaaaa atgtcatact tgagtcattt tagttcttga tttatgttaa gctgttggat 33720 tggtgcttct ccaaatactc actggaactg atgtttcaat tagatgtgga agacttaaca 33780 acaaattttt ttctggtaat tttcttccca aagcatctgg cagttcatgt tgcttatttg 33840 tatacttaca taaatatggg aattatatga gttgtgtaaa gctgtatttg atattcctgg 33900 atcatgttta aaaacatact ttgcataaca tcaattgagt gtgaaacgtg attaagagc 33960 ttagaaagat ctagctgagt acatttgggg ggaaaacatg caattattag ttgttttttc 34020 tggttgagct ttttgaataa cttgaagtag ttgctttgta tcctttatct actttgaaca 34080 cacacatagt tatcaaccct cattaaaaga caggatttta gacttaaact ttgtttttgg 34140 ttgaagacat aataaaatct cctcaccaat ttctgtaagt aaaaggaggg gtgtaatttg 34200 gagaactgca gtaatcctct taaccatttt cacgctgtta ttcctaaaat aagaagggtt 34260 gaccagatct caaacctaaa acattatgat tctgtatatt tctatccaga cattatata 34320 gattactcat ttgctttcat atatttgtat tatagttta cattttcaag caaaatatgt 34380 atcttttcaa gtggttttgt cactttttgg aaaatgcaac attccaagtt taatgcattt 34440 tttcaagga gagagcagag ttaaaggtgt aattcctttt ctttgggata cttctgccaa 34500 gagtctcaaa gaaagaatag tcattacaat gtaatggggg atgtaagtta atttgagaac 34560 tatgactagt tggatcagaa tgcagagcat ctgaattttt cttaatttgg tgttaaatat 34620 tcattctact tagacatttt aaatagta taggacaaa attcagac atttgtggaa 34680 tatatatgac tttgggata taaaccata tgggacagaa ttatagacac attattccctc 34740 aggatgtcac attgtatatat atagcacgggg gattcttggg gtatagagtc tgaaatccca 34800 aaactatatt taagttttt tggaccacat gcctttcttt agtacgaagt tccattttct 34860 tagattctca gatggtttca tgtccttttgt gaagttaag aaccacagat gcagtgagga 34920 ttgagtgatt gctttggcag cccctcttta aaaaacattt acctctcct gtattttg 34980 cttgtttgtt tgtttgaga caggtctta ctctgacacc ctggagtgca gtggcgtaat 35040 catggcttat tgcatcctcg acttcctggg ctcaagtgat cctcatacct cagcctccca 35100 agtagctggg actacaggca tgcgccacag cgcctggcta atttgtggg gagttttcgt 35160 agacacaagg tctctccatg ttcccaggc tagtctcaa ctcctgggct caagcagttc 35220 tcccatctga gcctcccaaa gtgctgggat tacaggcgtg agccaccatg cccagcttat 35280 tcttctgtta aaggaaaac tggtcttt ctgtcatggt atcctgaacc cat 35340 gtttattgaa tggtagtgac aaagccacat gagaccatag ataaaatata gcaatcttta 35400 tgctcttagc aatcttatga caaaatacat gcaagaggtt ttatataaga agagcataat 35460 tatgagtata aactgagaag gaattcgttt cacatttgtt gtgttttttg ccctcctata 35520 cctacatgcc tatgtttctc tctctttctc ctctctgtca gtctctctcc tctctctgtc 35580 tctgtctctg tctctctctc tgtcacacac acacacacac acacacacac acactttctt 35640 actccctcat tcagacatat acacatgctc atacccattt attgttgcca gtattttggg 35700 cttgttcata gaccagcttt ggtttgttgg agaaggttgg aagtgaaacc agaaaagttg 35760 tcataccatc tttgtgattt tggtgtattc aaagagaaac tggagatttg gttccttcaa 35820 atagtgattg ggcatatact aactggagtt cctaggagat ggtttaagaa ccagattgga 35880 ctcttttaag attaactcta aattgtgaca cagggcaaag agcagcatgt tcatagactt 35940 ggaaccaaat cacttcttca tagaaattag tgatttactt tatacagtcc tggcatatac 36000 ctttaatggc ttctggtaaa aattggatca taaataaata cttttgtgaa tttgtttttc 36060 ggtgtttaaa agttataaaa acaaacaaac cctactgtat gtgcacacac acaaactcca 36120 cagctgtctc agcttccacc agttgaaggt atccaagtct ccatttttgg tgtctgtata 36180 cttgcaatag aaacataatt tgtttttcca tttgacacta tgctacttaa cttgtcaaa 36240 gaaatagaa atgtgagtaa tccttataaa tgggcaaaca cagctattta agaaggatta 36300 tatattagct ctttggaagc tctttggtc atagataatt acctggaggc agttgttttt 36360 ttatataccc gagtttgata ttttgccagt tgagtttcaa acaatgaagt agaaatttgt 36420 ttatatattg cttagtcatt cttgttcata agaagagcat tctgaaattc ttaactatga 36480 atgggacctt gatttgaacc atatagttta aaatgcctga aaaattattg gctaagtcct 36540 cttgaatttt atacctcatg attatgagtt agatgtttta cttattcctt ctttgggagt 36600 tgtttggaaa aaactcaaac cctgtttttc ctctgccttc acaccaacac aacaatagtc 36660 aacacaactt ctgcgttagt ccattcttgc attgctataa agaaatacct gaggctgggg 36720 aagagacact taattggctc acagttctgc aggttgtaaa agcatggctc cagcatctgc 36780 ttctgatgag ggcctcagga agcttacagt catggtggaa gagaaaggga gccagtgtac 36840 cacatggtga gagcaggagc gaagcgaga gagagag gtcccaggct tctttacaca 36900 accaaatctc atatgaacta actgagcaag aactgacttg tcaccaaggg gatgatgcta 36960 aaccatttga gagggatcct ccccatgtc ccagtctct cccaccaggc cctacctcca 37020 atgttgggaa tcacgtttca acatgagatt gggaggggac aaacatccaa accatatcat 37080 tccaccctg gcccctaaa tctcatatcc ccacatttca aaatacagtc atgccttcac 37140 atagttccc caagtcttaa ctcattccag cattaactca aaagtcccca gtctgaagtc 37200 tacaaagtct catctggaga tgagttctt ccacctgtga tcctgtgaga tcagaaatga 37260 gttatttact cccaagatac agtgtagta cagacattg gtatacctcc tattccaaaa 37320 gggagaaatc agccaaaga aaggggcagt aggctctgtg aaatctgaa accagcagggg 37380 cagttgttaa atcttttttt ctttttcttt ttctctctct ctctcttttt ttttttaaac 37440 agagtctcac tctcttggcc caggctgcat gatcacagct cactgcagcc ttgacctctc 37500 tggcacaagc catcctccca cctcaccctc ccaggtagct aggacctcag gagtgcacca 37560 ccatgcctgg ctaatttttg tatttttagt agagaccgga ttccgccatg ttggccaggt 37620 tggtcttaac ctcctgagct caagtgatct gcccacctca gcctcccaaa gtgctaggat 37680 tacaggtgtg accactctg ccaagccagt ctttaaatct taaagcttca aaacagtttc 37740 cttcttgcca tgtgaaacct gcttccccct tgccttccgt catgattgta agcctcctga 37800 ggccctcccc agaagcagat gctagagcca cgcttcctgt acagcctgca gaaccgtaag 37860 ccaaaataca cttgttttct ttaataaatta cccagtctca ggtatttctt tatagcattg 37920 cagaaacgga ctaacacaaa attggtacca aggcatgggg cactgctata aagatacctg 37980 aagatgtgga agtagctttg gaactgggta aaaggcaaag gctggaagag tttggagggc 38040 aaagaagaca ggaagatgaa gaaaaatttg gaacttctga gagactggtt aaatggttgt 38100 gaacaaatg ctgatagcga tatgaacagt gaagtctagg ctgatgaggt tccagatgga 38160 agtgaggatg ttattgggaa ctagagcaaa tgttaccct gtcacatcct agcaaagac 38220 ctggctgtac tgtgtgccct agggataccc tcatcagttt ttcctcattc aagatgtggc 38280 ctggctgctt ctaacagcct atgatctaat atgggagca agaatgact taagttaga 38340 acttatatac aaagggaag cagagtgtaa aagtttggaa attttcagt caagccatgt 38400 ggtagagaaa gaaaaagtat ttcaggaga agaatcctag caggctgtgg agcaaccacc 38460 tgaaaaagag gttatcatgg ccaggggcaca gtagctcatg cctgttaatt ccagaacttt 38520 gggaggtcaa ggaaggagga tcactgggc ccaggagttc agaccactc tgggcagaa 38580 agtgagacct catctctaca aaaaaayaaa taattagctg ggtgtggtgg tgcatgcctg 38640 tagtcccagc tactcagggg cagaggcgggg aggactgttt gagtctgagg ggtcaggtt 38700 gcagtgagct atgatcacta aaatgagtttt ggtcatttct aagacactgg attataagac 38760 attaaaag aagatgtttt aagttagtat tatgtccagg taaggttct taaaaataa 38820 tttttaaaa agaaaaaaa gttagtttta tgagagaagg gggaggcccc agacttta 38880 acaaccagat ttcatgtgaa ctgagaagtc actcatcacc aagggatgg cactaagcca 38940 ttcaagagggg atccatcccc atgatcagt acccccact aggtcccgcc ttcacattg 39000 gggatcactt ttcagcatga gatttggagg agacaaacat ccaactata tcaacttctg 39060 tgacccagtg tgggggatg ggggttcccc accaatagc agcagacacc agctaggtat 39120 cctctaattt tgacactatc tgctgatg tagcatcaga tcttacaagt tgaggactca 39180 atccccaaga ttgccccctg cccttttcag acaccagtca taagtctggg cctctggaac 39240 acctgactga ctggctca gttggttt tcacagcccc ctcttgggt tcacttatt 39300 tccaggagtg gctcacagag ctcaggaaaa catgtttacc agtttagt aaatattac 39360 agaggataca atgacacat aaatgaggt atgggggaa ggatgtggag cttccatgcc 39420 ctcccagggc cacaccgccc tccaggacc tccacatttt cagctgtcca taagctctcc 39480 aaaccctgtc ctcttgggtt cttatggagg cctcattact tagacatgat taattaaact 39540 attggccatt ggtgatcaac ttgaccttca gcccctcttg ctcttccctg aggttgaggg 39600 atgggcttga aaatgctaac cctgtaatca tgcctttgcc tttttgctga ccagctccat 39660 cctgaagcta tcaatcaaca tgagcatgca aaaagacagc actttggaga tttcaaggat 39720 tttaggagtt ttgtaccagg aaacaggaac aaagaccaaa tatatattat atttcacaat 39780 atcattggaa ccttaagaaa gaagcctctc tcctttctta cggagcctag aggaataaag 39840 atataataa agattacttt atttatgaat agtaatactt tacaaagtaa tctttatt 39900 ctttattcta gtttgccctt gaaccattaa aggttactaa gttgaattca ggctgagaaa 39960 aacaaaatag caaagaaaaa catttatgtt tgagatttta gtgatttata ttctgagatg 40020 ttatgtaatg gaaatacttt tgagataaag caaaaaatac ttaacattct tttagttgtt 40080 gcaacttatt taagagtgtg tgtaattctt acccttgaaa cctcaaccta gacatttagt 40140 gattctgtt ttgaatgg gaaatcaag aaaagtca gattttaaa attgtataaa 40200 acatgtagtt gctaaaatgt aattttaagt cctccttagg gttcagtttt tatgaccct 40260 atgtcctcct taaggtttca ggaaacctcc ttaggttttc atgttgatag catattatat 40320 gattattat ggcagttttttctatttt aagttgtttt tctctgagat aaaatttctc 40380 taagtgggat ttttaatatt caagctttct tgacttttt tttaaaaag acataaacca 40440 aaccaagtat attcttacct gtatcttagta aagatttgtg tacatacatt taggatgat 40500 ttacatat gtcttgaagt gatattgt tttaggtgat tatatgtttt atacatgttt 40560 gtgttatact tcaccagtag tgatattgtc aaagcaaaaa aaatatgcag catcataaaa 40620 ttaacttgt ttcttttta aaaaatttat tcttaagaaa ccttacctgg acatatact 40680 aacttaaaat atcttctttt atatgtctt ataatccagt gtcttagaaa tgaccaaact 40740 cattttagtt attackctagga atcaaggt aagatggag agattggcaa ggagagggg 40800 ttcatgaatt gagagtagaa tgtgtaagaa gcatgaaata gatcacatcg agtctggata 40860 caacctcaga atccttctca atgcagtgtt ccaaatagct attaattact gattggagat 40920 ttggcccaga tactggtttt atgactaaaa gttgtcattt attgacatat tctctttctt 40980 ctaagcaaga gtaaaaaattt agatgcatac acccttgtct ttgttcatct gcttagaggc 41040 ttacatcatt agtgatcatg tcgtggggca aaattgggat tcagccccgg aggccacatg 41100 gttcttggct tcacggaggc aagaattcaa gagtgagcca aaagactaga gcgaaagcaa 41160 gtttattaaa aagtaaaagga ataaaaggga ggctgccaca taggcagagt agccttgagg 41220 gctgctggtt ggctattttt tatggttatt aataaataat agcataaatt aatcgtatgc 41280 taaacaagga gtggattatt catgagtttt ctgggaaagg gtagggaatt gtcaggacca 41340 agagttcctt ccctttttag accttatagg gtaacttcca ggagttgccg tggcatctgt 41400 aaactgtcac ggcacagatg ggagtgtctt ttagcatgct agtgtattct agttagcaca 41460 taatgagcag tgaggatcat tgaggatgag cagaggtcac tgtctttgcc ctcttgattc 41520 tggctggttg tggctggctt cttaccaca tcctgtttta tcagcagggt ccttgtgacc 41580 tgtgtcttga gaaacacgtt ctgccgaatt atctcaatca gctttttata gaactgtgct 41640 tttcactgaa tatttttttc ttattgcacg ttcatttcag atgaaaaacc tgagaaatgt 41700 ggtcttcgcc tttgcgttgg aaaagaattg atgccttatt taagaaacaa tcagctaggt 41760 gtggtggttc acacctatga tcccagcact ttgggaggcc gaggtgagag catcacttgg 41820 ggccaggagt tcaagaccag cttgggcaac aagctaagac cccgtttcta caaaaaaaaa 41880 cttaaaatg agttgggcat ggtggtgcac tcctgtggtc ctagttactt gggaggccta 41940 cgtgggaaga gtgcttgagc ccaggaggtc gaggctgcag tgagccatga tcacaccact 42000 gtattccagc ctgggtgaca gagcgagctc ctgtatcttt aaacaaaaac aaggaaaaaa 42060 atatcattta aaaaaaattt tgtgggattt tacatgtgct tttgccaaat tgcatgttgc 42120 tgaagagtgt tactaagcac tgacaacaga gtcttcctca gtcattatgt tgaaatacta 42180 tgtttcttcc cacaaataag aactgatttg atttaaatt attattattt tttttccaag 42240 acagattctt gctctgtcac ccgggctaga gtgcagtgac gtgatcttgg ctcactgtga 42300 ccactgcccc ctgggtcaag tgattcttct gccttgggct tctgagtagc ttggactaca 42360 gtcatgtgcc accacaccca gctagttttt ttgtatattt gatagagatg ggattttact 42420 aggttggccc acctgttctc aaactcttgg cctcaagaga tctgcccatg gcctccctaa 42480 gtgctgggat tacttgattt taaatgattt taatcagcaa tggtttgaaa gtaaatttaa 42540 gtgactaaga agtgactaag ttcctaaatt atttactcta ctcctcataa acaagtattt 42600 tcttataaaa ggcattaagg tttttccaag taaaattttt tggtataaat tgtttccata 42660 caatttaatt tatggtatac ctgtggtttt gcttttgcat ttggatcttt agcacttttg 42720 gatatctgat gaattttaac atatgctatt caatgaaatg agtttgttac ttgataccgt 42780 gtttaccttt agaataaagt gttaggtact aatattttag gagaactgac ttgaactcat 42840 ctcctggatt ctaaactcag cacaccacta atttgtgtgc tgggtcactt cactgctaga 42900 actgctgtgg cttttgctgc cactgtggct gtttgctatc acagattgat tgatggctct 42960 gtggcaaaca ctaccataga gccatcgatc aatatgtgat agcaaatatg tgagttttt 43020 tctgtagctc aaatccaaca gctttgcaag ggaagtagct tatcttcatt tggcaggaat 43080 gaagcctgag agagattgag tcatttgccc taaaatttgc tcataaccaa gttatgccct 43140 gtagttttca agcttcttag tttttccctc tctaaaaggg tatgacagaa cctgtatcat 43200 aagtagca attactttgc taaggctaca cagagcagca tttctgtttt aagacttagt 43260 aggagtgtat tcatgaccca gctcaaacac cacctcctca gcaaagcgca ttcaattctt 43320 ccttagtcac areatttgt tctctgggtt tctctaaaga acacatgcga atctgaaaga 43380 gccagaaatg tttcatttgt gtttttgttc ttttatccca ctattcttct cccctcccct 43440 ccccctccaa gaagaacta gcatggtgcc tggcacttgg catgaaatga cagagcctgt 43500 cacatctaac aaattaacca aatgggtctt ttgaaaagtc tcttctttat tacgttttgg 43560 aaaactgagt gcagcttatt tgcccagggg cttttgtatg aatatgagca tcatcagcta 43620 gcggcttttt cttgagtagc aagctatgtt aagtcacaaa gggtaaaagt aaaaaaaataa 43680 ttattatgaa tgaaattgtg ctctttttta atactttcca ttatcacaaa cttaaaatat 43740 ttatacttgg ttattgtaaa aatatataaa ttataaaaaat aaaattaataa gtgtattatt 43800 cccttaggc acatttcaat ttctaagcaa aatcttgttt ttgcttttaa tggctctact 43860 ttttttaaac tattaccctt gtcttattat tgttttacta gtgcatttaa ctagaccttt 43920 aagatattgg gggtttttgg tgtgtttcaa atttgtataa tagacattgc tctatgtaag 43980 aagataatca atacttacgg actttataaa aagttagcac tttccttcc tattgaaaat 44040 tgtctggaat tctaaaatac aattttaaaa caaattggat tcatcaaatg gtagaagaca 44100 gtaatttatt tttgatggga tggtttactg tgagaatcta atatataaac ttccttgatt 44160 tcccataaaa cttccagtaa gcatttttaa gtataatttt cctcaaattt cttctgaaga 44220 attcactgat tttaacatat cactgacagt aaggcagtaa aaaaaggggg gaaggtgttt 44280 actgcctttt gtataaaccc aaagcacctt gaaatttaca acttaaattt gagtcacagt 44340 ctagatttca tttcttctgt agcttgaatg caattaatag aactttgaac tcataatttg 44400 tgcatagctc ttttggtctc tttctttcc ccaatttata gttttcatgt gtgtgttttt 44460 atttgtcttg tatcttttct cctatttgct atttatttga ttaacttttg aatctaagta 44520 tgtaagactg tccataccac tgtctgtcct gtgctctcca acacagtagc caccagcaac 44580 atgtgattgt ttggtgctta aaaagcagct ggtctgagcg aagctgtcca tactgtaaat 44640 tatgcactgg atctcagaca cttggtagaa aaaagaatgt aaagtttact aatggcgtat 44700 aaattacttg ctgaaatgac aatagtttgg atatatcgtc atatcttgtc cccagtttat 44760 tagagttctt ctgtggggga aaggagag agttactgac agtaaattct tctggttaga 44820 cagtggaggt gttgctgctg ttgctgctat cctccctgac ctgttttgtg tgctaataga 44880 ttccatggag agcaataact gaaagttgaa tttaggattg cttctggctt tgaggtttct 44940 gcctaatggc taaaggattt aaaatgtaaa ccagtatatt tatattactt gtttttcttt 45000 taacttgtat ccttattaaa tttcattatt tagatggtga cagtagtgtt agtttagact 45060 tgaatatact cagatgtata aaggggccag gcaagtaaca aaggaatgaa ttcatcctat 45120 gttagacaat gtggaatgat acatgtgctg tgtaacaagt atatgccctc tctacagggt 45180 gggtaacctt attcctgttt agctgattat ggtcttacgg gtatatatgg acttgtgttg 45240 ccagatcttt cagatttcta agaagagcaa aaatctggat ttttaagaat cttaaacctc 45300 tcaattttta aatactgata agtaatgtaa aatttaaaaa tacttatgct ggtcaaacta 45360 aatatggctg tgttctgaat gctaccgctt ggtaacttca gacctaagag attgcttctt 45420 ggaaataaat acaggtttta ggtattttag atgacctaat taaagtatac cagttatgaa 45480 gagaggcttg gtaagcgcct gttgatgaat ggcttttaag ttttacacct tttagagaat 45540 attaatctga aagtagtgaa taattgtctt ttagtttgtt ttgaaatact gttaacagtt 45600 tcagtgtact ttttgagtat atatttctag cgtactctta tatatggaag ttattctgct 45660 ccttattttt tcttacatgc ttttctgtag ttattttgat atgaattgtt ttcctgaaca 45720 tttagaaaaa ggtttgtgtc agattgcttg tctcatctca cagagccccc ccgttctggt 45780 gtgtgtactg ttcagaagta tgatgggttg ttttctgaga tttcctggct ctgttcccct 45840 ccccccactt tcatctagac ttactttttc ctttatctct tctgtccctc tcctgcttgg 45900 ctgaaattcc actcccagca gtttctctag tgtgagccct gtgtttggag agttcacagg 45960 agctccagga ttctctagcc ccgggcctca ctgtaggcct gccttgcact caccaagtcc 46020 tggagaggac taaatacttc ccaatttcag ctgctatatc cagttcacac acagcgcttc 46080 cagtgaatac ctgtgggctg tttgggattc tcttgttctc agattgctca gatgctctgt 46140 ggcttctctc tgctttcttc aacagatact gataatatct agtgcttgag gttggatgct 46200 acttggagtg gttcatagag aatacttttc cacctagtta tgttgtaaat gtttcccatg 46260 ggtttttgga tttgctatct gcttgctgtg tttgtgtgtg ttgggggcag agggaatcag 46320 gaaggtctag aactgctgct tctatcctcc cagaaaatcc agatgcacta aattgataac 46380 ctgatgagtg gtggcaaaaa gtcacacagt catgttttgaa taggtttaca aattatattt 46440 aagaaaaata ttttttc tataaaggta gggaaaggc tagcagtca ttcactgctt 46500 cttataaaa attctttacc agaaaaaaaa atcatagaa acttcaaga aaagaattg 46560 attcagctca gtgttgaaag tggtttgtat tcctggcact ttatactccc actccCacc 46620 agagacacat tgttcagcc acaataggtt acatcactaa ccttttgg gttttgtaaa 46680 ccattaagga ttacatgaat taccatgtaa tcctgttcag acttggtaag acatttactg 46740 atattgctt gttcttattc cctagatata aaaaata taacacttta ttcaaagag 46800 ctccatggag taatattac taagggccag gttgctcagt tttgcaca gaaaggcaat 46860 acagtgttga atacacatc tgtttcaagt tcccatatct atagacact tctctctt 46920 taaacttaaa ggaaataatg tatgcacact tatggatt tacacagta cagtgatctg 46980 aatttcggaa cttaactttc agtataaaaa gtttagttct ctgccacacg gatttcagc 47040 cgtatgcttg tgtaatgtat ataaagattt aaaaaaatag atgggattat ttaaactaaa 47100 aaaagatgtg gaagttactc ctaagtgtaa atactatgtt ctatgacatt aatatatata 47160 ccttattttc tcttaatttc tatttgaagg tctcagccaa tttcttctcc agtcatcctc 47220 cagtttggtc atgcagagac tcttcttcca ctgctttctc tcatgggcta cttcaaagac 47280 aaggaacccc taacagcgta caattacaaa aaacaaatgc atcggaagtt ccgaagtggt 47340 ctcattgtac cttatgcctc gaacctgata tttgtgcttt accactgtga aaatgctaag 47400 actcctaaag aacaattccg agtgcagatg ttattaaatg aaaaggtgtt acctttggct 47460 tactcacaag aaactgtttc attttatgaa gatctgaaga accactacaa ggacatcctt 47520 cagagttgtc aaaccagtga agaatgtgaa ttagcaaggg ctaacagtac atctgatgaa 47580 ctatgagtaa ctgaagaaca tttttaattc tttaggaatc tgcaatgagt gattacatgc 47640 ttgtaatagg taggcaattc cttgattaca ggaagctttt atattacttg agtatttctg 47700 tcttttcaca gaaaaacatt gggtttctct ctgggtttgg acatgaaatg taagaaaaga 47760 tttttcactg gagcagctct cttaaggaga aacaaatcta tttagagaaa cagctggccc 47820 tgcaaatgtt tacagaaatg aaattcttcc tacttatata agaaatctca cactgagata 47880 gaattgtgat ttcataataa cacttgaaaa gtgctggagt aacaaaatat ctcagttgga 47940 ccatccttaa cttgattgaa ctgtctagga actttacaga ttgttctgca gttctctctt 48000 cttttcctca ggtaggacag ctctagcatt ttcttaatca ggaatattgt ggtaagctgg 48060 gagtatcact ctggaagaaa gtaacatctc cagatgagaa tttgaaacaa gaaacagagt 48120 gttgtaaaag gacaccttca ctgaagcaag tcggaaagta caatgaaaat aaatattttt 48180 ggtatttatt tatgaaatat ttgaacattt tttcaataat tcctttttac ttctaggaag 48240 tctcaaaaga ccatcttaaa ttattatatg tttggacaat tagcaacaag tcagatagtt 48300 agaatcgaag tttttcaaat ccattgctta gctaactttt tcattctgtc acttggcttc 48360 gatttttata ttttcctatt atatgaaatg tatcttttgg ttgtttgatt tttctttctt 48420 tctttgtaaa tagttctgag ttctgtcaaa tgccgtgaaa gtatttgcta taataaagaa 48480 aattcttgtg actttactac caggactttt ctcttcccca tgtcaaaata caatcaataa 48540 ttgatggtaa aagtttggaa attcaagca 48569 <210> 7 <211> 23545 <212> DNA <213> Homo sapiens <400> 7 gattctgggc caagatggca gcaatgagga aggcgcttcc gcggcgactg gtgggcttgg 60 cgtccctccg ggctgtaagt gccccgagcc gccgaggcgg cggccctgca ggcactctga 120 ctgtcagggt tgggggcttg gcccgtggtg actgctctct tagaggcgag gccggacagc 180 tctcaggcca gagtcgggag ggcgttggag tcctggaccc tcccttttcc cctcaaatcc 240 tttgaagggg atgggaaaac tgaggtccgg agaggtggag tgacttgtct gggtcatgga 300 gacctgggac gccatcctag gtgccctgat tccccgccca gggccctttc cgatgaccct 360 ggcccctttc tccctctaat tgaacttcag acctctccaa ctcttcatta gtgaaaatca 420 agaacacgct tccatttcct tcgtctccat ttccaactgt tgttgctttt agagatgctt 480 ggggaactat cccagcctac cgagcgggac ttgcgttgat tggagccaag ctgtgattcc 540 cttggaattg cactttgatc ctgttcgatc ctgatgtttt cccctccc attctcagcg 600 cagaaaaagt gtgggagacg tagctgtatg gagcagaaaa aataaaagct gaagctaggg 660 tgtcccaata gttctgccac tttctagact taatgacata gttatttact ttctctaaac 720 ctcagctctt tcgtctgtaa aacggacaac attcccttgg ggttgttttg gaaattagag 780 aaaatgtaag taacacatct ggcagtgttc tggctcctaa taagtgatca gtcggtggtg 840 gtatttttac cttagggagt tgagaaggag ttataactgt atagagggaa aaatacactc 900 ctggcactgg gtccctctca gaaagccacg ttaatactct tacttggcca ttcacctgca 960 ccacctgctc atgtgtaaaa tgaagatggc aattccaact tggaaagtta aacgcaatag 1020 tagatattaa tagactttta agaaatattt ggtgtaatga gatggccctc catggggttc 1080 caagcatagg aaccagtatt agtattaggc ctagatatgg gttcaagtcc aagctctgtc 1140 actttctaat tgtgattttt gggtaacctt tctgaggctt agtttcttca cctacggagt 1200 tgggataata atagtccctg gcctgtagtt taacactggg tttagtcagt attcgctgtt 1260 ggtgttgatg caggtacacc atacctcagg acactgtggc acagtactg tgtggttagg 1320 gggaccctct ctgagcagag ctttacagag gaggaacgggg atgttttacc aggagagac 1380 tgtggaccga acgaacggtg gtaaagaggc aacagtggcc cagaggttag gagcttgtgc 1440 tcgagcca cactgccagg tttagatt gcctcagtga gtactcccc atgtcacctc 1500 gggaagatta cttaatctct tggtctca gatttcttt ctttctttc tttttttt 1560 tcctgagacg gtgtcttgct ctgtcatctg tcacccagac tggtgcag tggtcaatc 1620 tcagctcact gcaacctctg cctcccaggt tcaagcgatt cttctgcctc agcctccca 1680 gtggggcctt agatttctta cagtaaatg gggatgatga tagttcctac ctgataagat 1740 tgttgagagg acagtatggg ttatatgta aatggctcac caggcgtggt ggctcatgcc 1800 tataatccta gcactttggg aggctgaggt gggtggattca cttgaggtcg ggagttcgggg 1860 accagcctgg ccaacctgt gaatcctgt cttactaaa atacaaaaa ttagccaggt 1920 gtggtggtgc gcacctgtag tcccagctac tcgggaggct gaggcaggag aatcacttga 1980 acctgggagg tgaaggttgc agtgagccaa gatcgcgcca ctgctctcca gcctggagac 2040 agaatgagac tgtatctcaa ataaataaat aaataaataa atatgtaaat ggctcttgta 2100 tgtgcctggc aaatattaag tgtttaaaaa ctgaattatt atgtgaagag ctgttacggg 2160 gaaggaagga agtggaattg agtttataat gttctaataa aagcagcttg gaagcaggtt 2220 ttagaagctt tttttttttt tttttttttt gagatgaaga agtctcgctc ttgtacccca 2280 ggctggagta caatggcacg atctcagctc actgcaacct cctcctcctg ggttcaagca 2340 attctcctgc ctcagcctcc cgagtagctg ggattgcagg cacctgctgc catgcctagc 2400 taatttatgt gtttttagta gagatagggc ttcaccatgt tggctaggct ggtctcgaac 2460 ttctgacctc aggtgatctg cccacctcgg cctcccaaag tgctgggatt acaggcgtga 2520 gccaccacgc ttggcctgaa gcaggtttta gattatttca gcaacactca actgttattt 2580 atcgagcccc tattatgtcc cagggcctta gaaatacagc attgaataaa acaaagtccc 2640 tgtctcatga aacttatgtt ccagtgagat agttttagg tgatatacta gcagaggctg 2700 aacatccctg ttggaggg attcaagttg cagggacctt ccaacttagc ctgttgacgt 2760 catgaaattc aatggctcat cgccttagtc tctaagaag cttgttggct aaaacaaggc 2820 cagtcaggtg agttgtacat gttccagctg cttcctagca gggaatttcct gggggacttc 2880 agggggttga gatccttagc ggatcacaca gtgtgccttc cgctttgcct cgttgtagta 2940 tatttatcca gatttaatct gtaaaacaa gttgatttga aaagttacag tatcagaca 3000 ggtagaggaa agaggaaaaaaagtattg tgttacttga tagggac tagattttg 3060 agctgacttt atagagga gactcaggggc atttgtaaa aactgtcttc agctactggg 3120 ggtgtcacct ccccttagac ccatgctgt catcacccag cctatgactg taacagaaga 3180 gagccctcct gcatctcgcc cataccccga aaagtccagg actgactact cctccccaca 3240 ctcagtaatt gctctcttct gggacagctg tgtccttcat gtttatgtg ttattttaat 3300 aactttaaag agtggctact ttgtaccaaa cacggtgcca aacactaggg atgaagtgga 3360 gttgagacag acaaggtccc tcaaagagct tatgttctac tggaagagac attgagtagg 3420 cattctttat cgtgctttga aggaaataat tatagctctg caatagcgaa aataatgggg 3480 gtgggaggaa tggcagcttt gcaaagggtg gtcagaggaa gcctctctgc aactgaaaga 3540 tgagagagag atgtaagaac agccagtttt tttaaaaaaa gccagatgag gaaccctggg 3600 gcagagggaa gagaaggcag ggagcttagc aacctgttgg gtggaggttg ggagtggaca 3660 gtaggggcga gtgatgattc caggaggtca gaggaggcaa ctcatacagt cttttctttt 3720 cttaattgga aagcatcaag tgacatatag agtcatttaa tttttttttt tgagacaggg 3780 tctcgctctg ttgcccaggc tggagtgtag tggcacagtc atagctcact gcaggctcaa 3840 ccttctgggc tcaagcgatt ctcccacctc agcctcttga gtagctggga ctacatgtcc 3900 attccaccac acctggctaa tttttctatt tttagtagag acggggtttc ttcatcatgt 3960 tggccaggct gatctcgaac ctctggcctc aagtgatctg cctgccttgg cctcccaaag 4020 tgctgggatt acaggcatga gccaccgtgc ctggcctttt tttatttttt ttggaaatgg 4080 agtcttcctc tgtcgcccaa ggtggagtac agtggcacga tcttggctca ttgcaacttc 4140 cacctccctg gttcaagcaa ttctcctgcc tcagcctctt gagtagctgg agttacaggc 4200 gtgcaccacc acacccggct attttttgtg tatttttagt agagatgggg tttcaccatg 4260 ttggtcaggc tggtctcaaa ctcccgacct caagtgatcg cccgcttcgg cctcccaaag 4320 tactgggatt acaggcatga gccactgccc cccgcaatac ctggcctttt taaactactt 4380 ctaacataca tacagcagca tacagagtcc tataggccat ggtgaatagg tgaaatggct 4440 caatgaagtt ctggcttatg cagtagggta catgcgatgc ctttgacaga gatggaaagg 4500 atggagtcag atgggcttta ggagaaatta gagttctgtt tcgggactgc tatatgaaga 4560 gatgcgaata gagctgtcag gtaggcagtg gaaaaggagt ctggacttca ggggagaacc 4620 ggtactggaa ggatgaatct cttgcttgtt cctgttacta agtgaaatat tctttttgtt 4680 cttaattcta aaatagacca aatgtgaatt aaatggtgag aaatatttct tcttgtctca 4740 ttattagtga agatagatcc attctttcat attggtctcc ctgggaattg tggcaatctc 4800 ttcctcatac tttgtttc ctctttaaa ccaaggtca gcacctcatc tatgggcact 4860 ttaccaaagc gggtgaaat tgtggaagtt ggtccccgag atggactaca aaatgaaag 4920 gtaaagttgg aaatgagcca aaaaaacagt ttttcaagc atctgctttg agtattacgt 4980 gtgataggtg caatggcagt tgacagagct atgcagatg tgattcctct gcacaagtta 5040 ggggagagta gaggaggcca aacagggaca gandacctgtg acagttaat gatctaaat 5100 ggtggggcaa gctggatggg tggctcatgc ctgtcatccc taattactg ggaggctgag 5160 gtgggaggat ggcttgagcc caggagttg agaccagtct gggcaata gcaagactct 5220 atcttattaa aaatatatg tatatatata aactgaatgg tggtgcaa ggttttggtgt 5280 ccccaggtcc acagccagt ggggtggggt agacccacca attccatgta aggggattta 5340 tccaaagcaa gtcacgaagg ccaatgtag agatttagcc tggggtgt tccttacaaa 5400 cctgttttggt aagcacagaa cagttggaaa caacttaat atttagtg aggaagttg 5460 ggtcagatac actatggact ttttataaaa tgaaatatta tgaagccatt ataacatag 5520 gtatatataa agtgactcaa gcagtttata aaatagtaca tgtgactggg catggtggtg 5580 gctcatgcct gtaatcccag cacttcagga ggctgaggca gagcacgatt ctgtctccaa 5640 acaaaaaaa atagtgcatg tgcgcgtacg cacgcgcgcg tgtgtgtgtg tgtgtttttg 5700 ggagatggca tctcactctg tcacccaggc tggagtgcaa tggcgcaatc tcggctcacc 5760 tcaacctcct cctcccgggt tcaagtgatt ctcctgcctc agcctcccga atagctagga 5820 ttacaggccc ctgccaccat gcccagctaa tttttgtatt tttagtagag atggggtttc 5880 accaggttgg ccgggctggt cttgaactcc cgacctcagg tgatccacct gcctcagcct 5940 cccaaagtgc tgggattaca ggcatgagcc aatgcgcctg gccatgtatt tttaatctt 6000 aacactttta tgtaagaaaa aagtttatat atgtatggga gcatttatct agactaggac 6060 ctagaccagc actttctgtg aagatggaaa tattctggac ctgagctttt ccatgtggtg 6120 gccactatac ccatgtggcc cttgagaact tgagatgtga ctagtgtggc caaggaattg 6180 tatttttatt tttatacaat ttttattaaa tttaaataac cacatgtgac tagtgacata 6240 ttgggctgca cagatctaga aagttacaca ccagggtgtt aatagcgtta tcactgggag 6300 attctaaggg tggttttctt ttgtttttgg catgtttttc tgaaagaatc atatattgat 6360 tattttttca ataagaaaag cttttttctt tttctctttt tttttttttt tttttttttt 6420 tttagcacgt ccatcctagc tttaatagtg agtgcttgtt ggaaacaata gtgtgtaagt 6480 tcccgaaggg cagaatcctg tctgttctgc ttctgcttac tgctatatcc ccggcaccta 6540 gcacaatgcc tgcaacatgg agggctttca aaaattattt gacaggctgg gcatgatggc 6600 tcatgcctgt aatactggca ctttgggagg ctgaggcagg cagatcacct gaggtcagga 6660 gtttgagacc agcctggcca acatggtgaa accccatctc tactaaaata aatgagctgg 6720 ggtggtggca tgcttgtgta atcccatcta ctctggaggc tgaggcagga gaatcgcttg 6780 aacccggaag gcggaggtcg cagtgagctg agattgtgcc actgcactcc actctgggca 6840 atacagtgag actccatctc aaaaaaaaaa aaattttgtg gaaagattaa gttagagcag 6900 tgggagagaa actggagaag gcaggcaagg ggaggaccta gcgagaagga cctggagtat 6960 ttttgtgtgt tctttttgtt tgagacaggg tcttgctctg tgtcactcag tgcagtggca 7020 caatcattgc tcactgcagc ctcgacttcc caggctccag tgatccacct cagcctcctg 7080 agtagctgga tcacagacac gtgccaccac gcctggctaa tttttgtatt ttttgtagag 7140 agggggtttc gccatgttgc ccaggctggt ctcaaactcc taagcttaaa tgatctgcct 7200 gtctcagcct cccaaagtgc tgggattaca ggcgtgagcc aatgtgtccg cctggacctg 7260 gagttcttag aattttttgc gtaatcctgt aaatattagg gagccataga aagcttttga 7320 tgcaagagaa tggaaggttg gaagctgcat tttaggagga ttcctgtgta agatgaatta 7380 gtggcttgag actatgccat gttatataca ggataatgat ggtagatttg gaaagaggaa 7440 tccatggaat ctgttgagct actggacatg gtggggagga agataaagaa gctatacgct 7500 gaacacatga ggctgaagtc ctatgccaat tgggagacag aagcgaggag ggtgtgatac 7560 tttgggggcc ccatcccata ctccccagag ggttagtcat ctctgccctt tcaggccatc 7620 acacattgct ctcagtttgt ttatgatggg attataaatt aacacacatt tacttacggg 7680 aaagcctgca tggcagaata atgtttctat gtaaataact ccttttcagg tgagaagctg 7740 catccactgc aaaaaattat ctatagtact tgaactaaca ggtactgcat tttgaggctg 7800 ttttgttact aactttgctg ccttggtgtt tctctctcca ctatagaata tcgtatctac 7860 tccagtgaaa atcaagctga tagacatgct ttctgaagca ggactctctg ttatagaaac 7920 caccagcttt gtgtctccta agtgggttcc ccaggtgagc cctagccctc aatgaaaggc 7980 ctttctctag ggatgaaaag ttttgcattt gcctttgaag caagtagaag ttgagaacat 8040 aggtttccaa gcccctggct ttgagaggtc tcaggtgatt catagcactg tgttgcagca 8100 aaagaacatg acccaggatt cagggccttg ggttcagtct tggctctgct ctgacttgct 8160 cagtgacatt gctaaggcct tcccctcctc agtgttagag atgacctctt ctagccctaa 8220 agtctaaaac cctctatgcc tgtctgtggt ttctttgttt gtaaaagagg aagactgaca 8280 actcctgctt cacaaagata gttaagtgaa gaagaaacat cctgttacaa aggagtgctt 8340 aacacagagc tgagctcagt gcctggccca gagtacattc tcaataaatg gctggtagta 8400 gtattcctgc tgtttctgca tatgtaagc tggcagtag ggccatatgg agaaattggg 8460 atctcagcca aaccaagggc ccttctgagc catcagcagt siaaaaca gtaaagtat 8520 tggagact cagctctgca gaaggaatta ctcgctaaga gttctggaga acagaggtttt 8580 tgtgatgaaa aggttttctc taactgaact ctctgtctgc tctggtgat gacttggcaa 8640 tgtctccctt gttcctaga tgggtgacca cactgaagtc tgaagggca ttcagaagtt 8700 tcctggcatc aactacccag tcctgacccc aaatttgaaa ggctcgagg cagcggtaag 8760 aggatagctt gttggtgggg gctcctgaaa tgagatgat ggcattggtc cctgccttgt 8820 cttggcgcct cagtcccctg tcctgggatg tccatctgaa tagctgtct gtcagccaga 8880 ccctggggca aacctggccc tgccactcac tgctctgtga tctgacag ttgacaagcc 8940 tataaaatag ggctaaatga tagtacctga agttgtgagc atttcagag atggatgca 9000 tgtacattgc ttagcaagg ccagataaaa ggtaactgct taataatgt tagctctttt 9060 gattatccac ttctttagag aaatgtaacc aaactcca caagtttc aacagtagtt 9120 gctggcatct gccaactttc ttacaatttt agacaagaac atctttggag gcgttggttc 9180 tgtatttagg caaaaacctt ttttggctg ggcacagtgg ctcacaccta taatcccagc 9240 actttgggag gctgaggccg gagaacagct tgaggccaga agcttgagac cagcctgagc 9300 aacataagga gaccttgtct ctacaaaaaa aaaaaaaaa atcaattagc tggctgtgat 9360 ggcatgcacc tgtagtccta gctactcggg agactgaggc acaggatggc ttgagactag 9420 gagttcgagg ctgcagtgag ccatgataat accgctgcac tcttccagcc tgggtgacac 9480 agcaagaaaa aaaaaaagc ttttctcaa gagtgacttc cagggtggtg atggcagtgg 9540 tggtggttc cttggggaaa atcaaagtttt tttttttttt attaagaga aattactgtg 9600 tttgtttcct agtgctactg taagaaagca ctacaggccg ggcgcggtgg ctcacgcctg 9660 taatcctagc actttgggag accagggcgg gcggatcatg aggtcaggag atcgagacca 9720 tcctggctaa cacgatgaaa ccccgtctct actaaaaata caaaaaatta gccaggcttg 9780 gtggcaggta cctgtaatcc tagctactca ggaggctgag gcaggagaat cacttgaacc 9840 cggaaggcgg aggttgcagt gagccaagat catgccactg cattccagcc tgggtgacag 9900 agcaagactt tgtctcaaaa aaagaaaaaa gaaaaaaaaa aagaaagcac tacaaattgg 9960 gtggcttaaa aacaacagaa atttattctc tcacagtctg gaggccagaa gtcccaaatc 10020 aaggtgtcag caggattggt tccttctgag gcctctggga gaatctgtcc tatgcctctc 10080 tgctggggtc tggtggtggc cagcagtcct tggcattgcc tggcttgtag atgcatctct 10140 ccagtctttg cctccgtttt cccagggcca ccttttctgt gtctctgtgt cttcacttgg 10200 ccatcttttg tttttgtttt ttttagacag agtcttgctc tgtcgcccag gctggagtac 10260 agtggcatga tctcggctca ctgcaagctc cacctcccag gttcaagtga ttctcccacc 10320 tcagcctccc gagtagctgg gactacaggc gtgtgccacc acgaccggct aattttttgt 10380 atttttagta gagatggggt ttcactgtgt tagccaggat ggtctcgatc tcctgacctc 10440 atgatctgcc cgcctcggcc tcccaaagtg ctgtgattac aagcgtgagc cactgcgccc 10500 ggctggccat ctttttttaa ggtcaccagt cgtatgggat taggggccca ccctattcca 10560 gtatggcttc atcttaacta atgatatctg caatgacgct gtttccaaat aaggtcacat 10620 tctgaggtgc tgggttttaa tccttcaaca tatattttta ggaggacaca attcaaccca 10680 taacattcac ataacataa atttacctta agagaaattt tttgctactc tgtgtcagtg 10740 ttctttaaag agaaaagtgc tggccgggca tgatggctga cacctgtaat ctcagcactt 10800 tgggaggctg aggtgggtgg atcacaaggt caggagttcg aaaccagcct gaccaacatg 10860 gtgaaacgct gtctctacta aaaatacaaa aattagccgg gcgtggtggt gggctcctgt 10920 aatcccagct actcaggagg ctgaggcagg agaatcgctt gaacccagga ggtggaggtt 10980 gcagtgagcc gagatcatgc cactgcactc cagcctgggc aacaaagcaa gactccatct 11040 caaacaaaaa aagaaaag tgctgaaagg agttcacctg gatgttggca ggttgctgct 11100 ggagccaagg aagtagtcat ctttggagct gcctcagagc tcttcaccaa gaagaacatc 11160 aattgttcca tagaggagag ttttcagagg tttgacgcaa tcctgaaggc agcgcagtca 11220 gccaatattt ctgtgcgggg gtgagtcaga gcacattggt atcctttcct ctgtaccgtt 11280 ctggaatggg gctagactct gactcaagtg gtcctcctgc cacaaacttc ttatcctggg 11340 tgggggcagc ctgagctcca cacctagaca tcttttccca aataagtgtg gtcagaagaa 11400 atcctaggaa gtactttctc tcaaacctga attttgggtc agtttaccag ctagccatga 11460 tagcatgcgc ctgtagtcct agcaacttgg gagactgagg cagaggatgg cttgagacca 11520 ggagtttgag gctgcagtga gccatgatag caccactgct atcatgctaa aggaatctag 11580 caggacagga cactaacggg tttgtggagg tcagttgagt cctggcttta tcactagctc 11640 ttcacacatc cctggagaat tacctaggct tctatgtttc caacatcaca tctctaatat 11700 cagtggttcc aggcattgtg tgtgtattat ctataataat tgaaacctca caatagccca 11760 gcagggagta ggttatcctc actttataaa ttacaaaacc gaggcccagg aagggcgaat 11820 actctactgt aaggtcacac tgctgtgcaa attgcagcca gaggccgggc atggtggctc 11880 acacctgtaa tcccagcact ttgggaggac aaggcaggtg gatcacctga ggtcaagagt 11940 tcaagaccag cctggccgac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 12000 tgggcgtggt agtggataga aaccccgtct tacaaaaa tacaaaatt agctgtaatt 12060 ccatctactt gggaggctga ggcaggagaa tcacttgaat ctgggaggcg gaggttgtgg 12120 tgagccgaga tcaccact gtactccggc ctgggtgaca gagcaaact ccatctcaa 12180 aaaaaaaaaaaaaaaaaaaacattgcag ccagatgat cgttgaaag tgcacatctg 12240 ggctgaacat ggtggctcat gcctgtaatc ccaccactt gggaggccga ggcggggcaga 12300 tcacctgagg taaggattt gaaaccagcc tggccacat ggggaaaccc catctctact 12360 aaaaatacaa aaattagccg gggcgtagtgg catgcacctg taatcccagc tactcaggag 12420 gctgaggcgg gagaatcact tgaacccagg aggagggt tgcagtgagc gagatcacg 12480 ccactgcact ccagcctagg tgacagagtg agactctgtc tcaaaaaaaaaaaaaaaaa 12540 aaccccacaa aagtgcacat ctgatcacat ccctcctggt taaaaagctt tcagtgacta 12600 atcaagtgca gactttttaa tgaggtttac aaaccctgca tgatttggtc ccggctcttt 12660 tctgtagccg taccgttcaa gttcccttct ggcccctgct tcctcttcat ggtacactcc 12720 agcccaactg gaacttcttt ctgtttgtca catgcctcca ctcttgcctc tgggcctttg 12780 cacgtgctct ctctagactc agaacaacct tccttgggag gccaaggtgg gcaggttgct 12840 tcagcccagg agtttgtgac tggcttgggc ctgggcaaca tggtgaaacc ccagctctac 12900 aaaaaaaaag ccaggtgtgg ttgcatgtgc ctgtagtccc agctactcag gaggctaagg 12960 tgggaagatc acctgagcct gggaggtcca agctgaagtg agccaaaatc atgccactgc 13020 acaccagcat gggtgaaaga gtaagactct gtctccaaaa aataaagaac acttcctcca 13080 catcatgctt ctcggggata actcctgctc atccttcagg tcttcttgtg ggagtcagtt 13140 cctctgagaa gctgctccag tccttcagct ggagttagtg cccttctctg ggaccccatg 13200 gtgtcgggac atcctctaaa tgtagcactt agctgcttgt taaattccct ccctgcccca 13260 ccccactaga ccgtgcactc catgagggca aagcccacat ctctcccagt ccctggggtg 13320 ctccactctc ccagcttggg gcctagccac agtgggcact cagtcactga cgggcaggtg 13380 gatgaatggg gaagcaggtg ctccagtaac attggcccaa ctcccagatc tgtgtctttc 13440 taagcatctc tcttaccttt ttcttgctca gcagtggttg gagaataagt gggagcatca 13500 aaatggaaaa gtacactgag atctttgagt ctgaaattat ttatctgttg aacatttatt 13560 atgcctctta atatgcagaa tttgcttgac tctaaagggt tttaaagaca gctcccaaaa 13620 gggcaggtgg gaatagaagt cacctacatc ccaaatccac cctccttacc atagccctaa 13680 gacccatgat cagacctgtg cccaccttgc tgacctcctc atctcatact tcctttcccc 13740 ttgctctgtc tgcctcagct gtcctttgtt ctgtctggag catgcctggc tcttctgtct 13800 cagggctttg cccaggtctt ccctctgcct ggaatgctct tctcacagac cacccccggc 13860 tcctctcggc tccagcatcc tgtcctcaga gggatctttc ctggaccctc actagttggc 13920 ctcctccact tgttcctatc atttcccatc tttcctctgt ggcacatcac ttctgagatt 13980 ttctccatta cttacttggt tgctttttta ttggccatct ccctaacttg agataagctc 14040 tgagagggca ggaaccttat cagtcttgcc cactgctctg tgccagtgcc tggcacatag 14100 caggcaactc agtaaacatc aggtgaataa atgaatgaat gaatcctcta gcatctcact 14160 ggggcagctc atcccttggt cctcaggcca gcccagcctg ttactgactc atatccaact 14220 cagctcttgt tctgagtttg gttttaccca gtctttggtc tccttttgga gtactggccc 14280 cagctcctct ggcacgtagt tttgctccat ctccccacct tacaacccag ctgcttactc 14340 tccttgccct ctctagctcc tcctccgctt attgtaaatc cttggctgcc tctcctgagg 14400 cctgtgcaac ttctgcttcc tcaattgtag gtccattgtc ccccagttcc ctgccattgc 14460 tctctactgc ctcctcctgg cactgaattg taccatccct gcccttactc cgcccagctg 14520 caggtgttga ttgcacactg atcagaaatg tgtgttaaac agccctgcct cagttctgct 14580 agccaaaaag ctcaggacac tgacctcatt cctcccctgt cttcccacag gtacgtctcc 14640 tgtgctcttg gctgccctta tgaagggaag atctccccag ctaaagtagc tgaggtgtgt 14700 gcatgtgtca gggcgggggg tttggtgagg gttggccacc ttgtctgccc ctgagcgcat 14760 aggttcctct ccccaccctt tctggcaggt tcctgacttc attcattcac ccagctcctt 14820 cattaagctc ctgctgtgag cacagccctg cacttgctcc ctagaggccc ccctcctagc 14880 cgaacatgta gtccttgaag cccctggcct ctatccagcc tgaaaacctc caattcagtt 14940 tccagtctgg tcgttgaggt gattctctga ggaggggctc cttacccagg agttcccata 15000 gttccttgta gtgattgaaa ggccacaacc ctgatgtcct ctgaacagtc accaggtcaa 15060 cactgagaag aacatggcat gggaattgag tttgaccagc ccaagaactt atgtcattta 15120 gtcctcaaaa ccactgtgca aatttggtat tattattccc ttttacagtt gagaaaactg 15180 acactaaata acttgccaca caggttacaa atggtgaaat caggtatcaa accccatttt 15240 ttctctctcc aaagcccact tcttcccagg atactttgtg gcatccagat aggtggaatg 15300 gtaacagtag caactgtttc ttgagagcag ctgccctgct ccaggtctta gcctcagttg 15360 ccacaatcct tgccgtatga ccaaagggtc atcaccattt ttcagaagca gaaattgaag 15420 ctcagaaaag tgaagttgct tgccaaggcc cacagctagt gaacagcaga actaggactt 15480 taacccagca tctcgtgact tcaaaggcct gctccttccc ctgcaccctg ctgcccccta 15540 aaggccagcc actgccgccc cacactctgc agggccactg gggaagcgac gtcaccattt 15600 catttattta gcagatcact ggtgtcttct ggtccccttt ccctgccaca tccctctgca 15660 ccttgtccag cagccccgtg tgggcagcag ctccttgggt gaggccatct ttttttaagt 15720 tcaccagtcg tatgggatta ggggcccacc ctattccagt atggcttatt ccaattggac 15780 ccatattgga cctattccaa tatggaccca ttttgcagtg gttttagaga tgtgcaaatg 15840 ggcttccaaa aatttaaata gtgatgtacc tctattaaaa aatataacta ttggccgggc 15900 acggtggctc acgcctgtaa tcccagcact ttgggaggct gagatgggca gatcacaagg 15960 tcaggagatc gagaccatcc tggctaacat ggtgcaaccc cgtctctact aaaaatacaa 16020 aaaattagcc gggggtggtg gtgggcgccg gtagtcccag ctactcggga ggctgagaaa 16080 ggagaatggc gtgaacccgg gaggcggagc ttgcagtgag ctgagattgc gccaccgcac 16140 tccagcctgg gcaacagagg gagactccat ctaaaaaaaa aaaaaaaaa atatatatat 16200 atatatatat atggactatt gattggccgg gtatggtggc tcatgactgt aatcccagca 16260 cttcgggagg ccgaagcatg tggatcacct gaggtcagga gttcaagacc agcctggcca 16320 acatggtgaa actccgtctc tactaaaaat acaaaaaata gtggggcgtg gtggtaggtg 16380 cctatgatcc cagctacttg ggagactgag acaggagaat cacttgaacc caggaggcag 16440 agcttgcagt gagccgagat tgtgccactg cactccagcc tgggcgacag agtgagactc 16500 tgtctcaaaa aatatata tgtaaaatat atacattttt atacatatgg tccaagctac 16560 ttgggaggct gaggtgggag gattgcttga gtctgagagg ccaaggttgc agtaagccga 16620 gatcacacca ctgcactcta gccgaatgac agagtgagac ccggtctcaa aaaaaaaaa 16680 aaaaaaagaa aaaaata actagcatct cagacccatg atttcatgga ttttattgct 16740 gaggataaaa cgacatggaa ggaatcaact tcactgattc cagcacctgg gtctgacagt 16800 atgatgtgac agccgtaagt gagactgaag tctgaggggc acaggtaggg aggaaagcac 16860 gggggttgga gcttcaggac tgtgggctgg ctccagcggc tggctctgcc ccttacgcct 16920 cagtctcctg atcatagatt gaggatcatc attcccagtt ggagtggtga ggagcatgta 16980 atccagtagg aactgagtgc gtcataccca gaagtgttct gcccaggcaa aggccccctc 17040 ttctgagtgc atggatcccc tggctggtgg attctgtatc ctccaagtgc ctgcttgctt 17100 ccttaggtca ccaagaagtt ctactcaatg ggctgctacg agatctccct gggggacacc 17160 attggtgtgg gcaccccagg gatcatgaaa gacatgctat ctgctgtcat gcaggaagtg 17220 cctctggctg ccctggctgt ccactgccat gacacctatg gtcaagccct ggccaacacc 17280 ttgatggccc tgcaggtaat caaaagcata tgcccattct cccaaaggtc acggtgggca 17340 ggacagcttg ttatcattta ttctttcagc aaacatttac tgatgccagt atgccaggtt 17400 ccaagctggc aatggtggac acagtcatgg tgaccctgcc cagatgtgaa gtgtacagct 17460 ctgtgttggg gagacagtca agggagttac atggcaatcc cactgcatta tgacagatgc 17520 catgaaggga ggaagcatgg ggctcaggaa gcctagaggg gccccatccc agctgaggag 17580 atctgggagg atttgcaaaa gaggcctcag tgaagcttga agaacataaa gtaagctgct 17640 gttgagggaa gaggaaagat gactaggcag aattgcacct caggactgat gtggggttca 17700 gggaggactc atacaatata cagggttttc agtgtgcggg tgtgtagcag aagcagatga 17760 ggaagcagga ggtagagaag ctagcagagg tcactcagag ggagaggctt taatgccgtt 17820 ccccacagat tgagctaaga cctcagatta gtttcctttg aggtttgctt ctcgtgggct 17880 ggtccagaat ggagatccat tggctggcag ccagatagaa ggagcattct tagtgtctga 17940 ccacagctac cttgctgtag cattggccta accttccatc tctaggatag tgatggcagt 18000 tccagccact ttttttttcc tctcaattat cccctagagg ttcgtgtcta agccaggtga 18060 gtctgttatg ttctgggtcg gtttcctcag agttgtggct gtcaaggtta aggttcgtag 18120 ttctgtggtc tcctcatttt tcagcttact gtgataccct gccctggttc ctgggctttc 18180 cttcagctca tgcgtttccc agccaggcag acaggaagag tgacttcctc tcctatgcct 18240 tgccaggcag gtaaagggga attctgcaca gctgaggtga gtctgaggca aaacttcatc 18300 ctgatcacgc tcaggacact cctgctcctc tgtgcttctc tgtttcatgg cagtgatatc 18360 tcagaatccc ctttttgaaa atttatcagg gaacaggttg agctgtgtga cgtctggcag 18420 tagcttcctc tgacctccct cttccatcag ttacttcgga aatatggatc gatgtgccag 18480 gttaagtgct gacttagaca atggtaacaa gacccaatcc ctgccctctg ggagctcatg 18540 ttatggtggg tggggaagac agatggaaga ttacaggcgt gtaaatagca cattgtaaga 18600 ccatttattc acctattaaa acctaaccta acggtgccta gtgtgctagg cactgttctc 18660 agcattaagg attcagctgt gaccaaaaca gagtctctgc cctcatgagg ctgacactct 18720 agtactatga gacagataat aaataaacaa acatacagca ggccaggtgt tcataaacac 18780 tgtggagaaa aaatgaagca ggttaaggca gtgccaggcc tttctgtaga gtggcctcac 18840 tcagaaggta gcatttgaga gagacctgag ggaagcgagg gagtgagccc tgcggatccc 18900 tagcagggag ggggagggaa gggagcccca cccaggaaag caggcgcaga gccctgaggg 18960 aggagtgtgc ttgctgtgtt cagggatcag gaggaggcat gtggcgggag cagtgtgact 19020 gaggagaggg gggcagagat gtcagggtta gaggaaggcc agatcggggg ccttgtagga 19080 ctttgactct ttcagactga gctgggaagc taacagagag tcttgagcag gggcggggag 19140 ggagatgatc tgaaatgttc cgtttgagag gctcctcggc tgggcacagt ggctcacacc 19200 tgtaatccca gcactttggg aggctgaggc aggtggatca cttgaggtca ggagttttga 19260 gaccagcctg gccaacatgg tgaaaccctg tctcaactaa aaataaaa attagctggg 19320 cgtggtggcg tgagcctgta atcccagcta tttgcgaggc tgaggcatga gaatcacttg 19380 agcccgggag gtggaggttg cagtgatttg cagtgagctg agatggcgcc agtgcactcc 19440 agcctaggca acagagtgag acttcttatc aaaaaaaaa aagaggctcc tctgggtgct 19500 gtgtagaga tacactgtag agagaagac cagtttggag cctacagcaa tccaggtgag agacatggca aggaggcctg gagggcagag gtgcgtgacc ggatctcagc agttcgtgtt ctgatctgtg aagctcgaga catctatagg caggtgtgtt aacctgggtg cagttaactg ggagtgagtg ggagagaga agctgtctga ggagagca gtaagggctc caaccgagat cagggaggtg aggaagagcc agcaaagact ggatcgaggc ctcaggagag gctagagcac 19800 taggaggaa accaagggat gtggagccct ggaagccaca tggagaaggt gtccaagatg atgcggctag tcaagtgcaa agatgaagag acttgacctt tgtacttagc tacatggagg ccaccagtgg ccttgactag agctgtttca gtggaggagt tgtggggacg caaacctgtt tcgaatgggt tcaaatgaga atggtaggatg ttaaatggga acagctcttt tgagggactt tgctttgaat ggggggaaag aaattggagg ttagaggggtt ccaaaaaggt ttgtaaaaga tgggagat cgcaggctgt gtgagatga cccagtggag gggagtaaca ggttgcagca gagagggaga gacttactgg agcacatcct gaagcaggtg ggaatgggcc tcacgccaag gtggaggggt tggccttggc taggctca gggtccatct caggcagcat gaggcagt gggtctgtag gcccagatgt aggcaggtgg gtagatgtga tggtgggaat caatggagac 20340 atctcttgat tgcatccatt tccataaagc agcagatgag aatgaggatg gggaaggggg tgatagaggt ttaagaagag aggagaaagt gaaatagtca tttgggatag tgggaggtga ctgacctggg aagatgggat gtggccctcg tgtggcaagg ccctgactga gtgagagtag 20520 cctggaggtg gtggggggta agtgggggggg gggtaataaa tgaatcacag taaacaacag gggtctgaaa tctcagcagt gggagggggt taggctggtg atcagaaaag gtctccctga 20640 gcaggtggct ttcagactgg aacctaaaga atgagagttc accatgaaag gaaagatact gctggcagag gaaacagttt aacagaaact aaaaggaga gcactgtctc tttctgtggg attgtcatgt caacagaatc ataagccaaa gcaaagaatg actctagaat ttcaggcaac agacgattgg gaggtttgca aggctcatct ctgtggcctc ttgtccccag caacaactgt gtttcaccat ccttatgttt ctagatggga gtgagtgtcg tggactcttc tgtggcagga 20940 cttggaggct gtccctacgc acagggggc tcaggaaact tggccacaga agacctggtc 21060. tacatgctag agggcttggg cattcacacg gtaagcccac ccaccccctg gtggcgacag ccccgaactg accagggggc ctgaagctga gaacaaaagt ggatggggggt atttggggtt gttaaggtgc tgaggagtaa agaggaag ggttagccag gcgcagtggc tcatgcctgt aatctcagca ctttggggagg ctgaggcagg agggtcactt gagcccagga gtttgaggct gcagtgagct atgatcctgc cagctgtactc cagcctgggt gaaacagcaa gaccctatct cttcaaaaca aaacaaaaga ggggaagggt gttggggatt atggatattt gatctatat tttaatgttt gtgagagtag ggttgagtga ggccacacgc atgggcataa gaaggctgga gtgtcagggt gactttgaca gttcagtcct aggagacacc aggaacatgg aaggggccct 21480 gggaagggtc aggttcatga cctgaaatga gtcagttctc tcttggcttt gttttgttct ctgtaaaatg aggacagtag cgttagacag ctcaccaggg atccgccaga gtccaccagg gccctcagtg gcgggacgga agcagaatag catctgtgct taaagatcag atggaactgg 21660 gtttaaagcc tactcctgcc actcccaggc tatgagacct cagacaaatt atttcatctc 21720 21780 aagtaagaaa acgtacgtag agggccaggc gcacgcctgt aatcccagca ctttgggaag 21840 ccaaggcggg tggatcacct gaggtcaaga gtttgagacc agcctggcca atatggtgaa 21900 acactgtctc cactaacaat agaaaaattg ctgggcacgg tggctcacgc ccgtaatccc 21960 agcactttgg gaggccaggg tgggcagatc acctgaggtc aggagttcga gaccagcttg 22020 gccgacatgg tgaaacccca tctctactaa aaatacaaaa attagctgggg tgtggtggca 22080 cgcacctgta atcccagcta ctcgggagac tgaggcagga gaattgcttg aacccaggag 22140 tcagaggttg cagtgagcca agatcacgcc actgtactcc agcctggcga cacagtgaga 22200 ctccctctca aaaaaaaagaa aagaaaaatt agctgggtgt ggtggcacac acctgtaacc 22260 ccagctactc gggaggctga ggcaggagaa tcactgaac ccgggaggca gaggttgcag 22320 tgagctgaga gcgtgccatt gcactccagc ctgggcgaca agagcaact ctgtctccaa 22380 aaaaaaaaag aaaaaaagt tgtagaat gcttatcaca gagctgagca cagagtgcac 22440 ttcagcaaat atgagctact gtatgacag agggtttctg tctggccctt tcagttggtg 22500 tttttatccc tccctctg cctcacaatt gtcacttga tatcagtttt tccctctgt 22560 gggccaggcc ctgtgctggg ccctgaagg ggagtactga acagactga tagatctgt 22620 gccctggtag tggcactaca aaccatgaca gagattgggc atcttacatg agggggtc 22680 agaggaataa cccaggtgcc agacagacag gagctcacag gcagctgtg cccgctgtc 22740 aaggaaaaag cctgtttatc ttcacctta ctttcagta tcacagttgt ctgtccatgc 22800 tgatgttttc cctgtgttg agggcatacc atgacttacc gcatcctcta acttgttttct 22860 caaagggtgt gatctccag aagctctgg aagctggaaa ctttactgt caagccctga 22920 acagaaaaac tagctccaaa gtggctcagg ctacctgtaa actctgagcc ccttgcccac 22980 ctgaagccct ggggatgatg tggaatagg ggcacacaca gatgatcat ggatggggac 23040 atggaaatga gataggtta aatggtgcag gtacctcata gccagctcta cacagaggtc 23100 tctcctggca gaagcaggc gaagggcagg aggagctgct tggcagagg accctgcc 23160 cagacctgag gagtgagagg ctttgaggggc tgaagtctcc ctttgttacg gaccctggcc 23220 caggagttga atgcctgagg acgtgtggga accccgttcc ctacttagca tgatccttga 23280 gtctccctctc tggatggaat cggcgagctg gccacctggc caccctc acggctccac 23340 cctgccatgg ccgtggggcc cttgctct gactctcag gacaggctc atggaggttc 23400 ttcccaagct ggcagaggcc atttgtggaa agtggagagc tacgtggtgg ccgtctgcca 23460 actccagcat ctctggaaaa tctccacgct gatgtgattttgaaaca gcttatgtaa 23520 ttaaggttg atggcacat cata 23545

Claims

1. A cosmetic skincare composition comprising: a) A combination of nicotinamide, palmitoyl pentapeptide-4 (pal-KTTKS), and acetyl tetrapeptide-11 (ac-PPYL); and b) Dermatologically acceptable carriers; in, The weight ratio of nicotinamide to pal-KTTKS to ac-PPYL is between 500:1:2 and 1:1:0.5; wherein the nicotinamide is present at 0.05% to 10% by weight of the composition.

2. The composition according to claim 1, wherein the pal-KTTKS is present in an amount of 0.0001% to 2% by weight of the composition.

3. The composition according to claim 1 or 2, wherein the ac-PPYL is present at 0.0001% to 2% by weight of the composition.

4. The composition according to claim 1, further comprising at least one additional ingredient selected from sunscreens, oil-controlling agents, antioxidants, protease inhibitors, anti-inflammatory agents, moisturizers, exfoliating agents, skin-brightening agents, anti-acne agents, anti-wrinkle agents, pH adjusters, thickeners, preservatives, and combinations thereof.

5. The composition according to claim 1, further comprising at least one additional ingredient selected from vitamins, minerals, peptides, glycosamines, flavonoids, phytosterols, N-acyl amino acid compounds, tyrosinase inhibitors, antimicrobial agents, and combinations thereof.

6. The composition according to claim 1 further comprises an antifungal agent.

7. A non-therapeutic method for treating skin oxidative stress, comprising: Identify the target skin region to be treated; as well as Apply the skin care composition of any one of claims 1-6 to the target skin portion.

8. The method of claim 7, wherein the method improves the appearance of visible signs of skin aging during the treatment period.

9. The method of claim 8, wherein the processing period is at least 2 weeks.

10. The method of claim 8, wherein the processing period is 4 weeks.

Images