A small animal independent ventilation non-magnetic cage negative pressure feeding system for extreme magnetic environment

Abstract

The application discloses a small animal independent ventilation non-magnetic cage negative pressure feeding system in an extreme magnetic environment, which comprises an extreme magnetic environment generating coil, a negative pressure cover, a small animal feeding non-magnetic cage, a cage placing rack, a circulating air feeding unit, an air purification unit and an air pipe, wherein the extreme magnetic environment generating coil is mainly used for providing a variable extreme magnetic environment required by small animal culture in a space; the cage placing rack is mainly used for placing the small animal feeding non-magnetic cage and providing an independent circulating ventilation pipeline required by the small animal feeding non-magnetic cage, and is also made of non-magnetic material; and the small animal independent ventilation non-magnetic cage negative pressure feeding system in an extreme magnetic environment disclosed by the application is mainly used for deeply studying the influence mechanism of the extreme magnetic environment on living beings, so as to guarantee the life safety of astronauts in different magnetic environments in the process of space exploration and future extraterrestrial immigration.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of life instruments, and mainly relates to a small animal independent ventilation non-magnetic cage negative pressure feeding system used in an extreme magnetic environment. BACKGROUND

[0002] Generally, we usually say the static magnetic field refers to the magnetic induction intensity and the direction of the magnetic field does not change with time; According to the size of the magnetic field intensity, the static magnetic field can be divided into sub magnetic field (< 5 μT), weak magnetic field (5 μT ~ 1 mT), medium magnetic field (1 mT ~ 1 T) and strong magnetic field (> 1 T). The extreme magnetic environment generally refers to the strong magnetic field, weak magnetic and sub magnetic field environment; In scientific research and industrial production, people will also create extreme magnetic environment, the electrical properties, mechanical properties and magnetic properties of the material under the extreme magnetic environment will change, these new properties have broad application prospects and great economic value in the field of material science, life science and physics; For the animal body, long-term exposure to extreme magnetic environment may have a series of negative effects, such as: for birds, studies have shown that strong magnetic field may affect the direction of birds; Strong magnetic field can cause birds to be unable to determine the north and south direction, and affect their normal migration behavior; Extreme magnetic environment may also affect the sleep pattern and adaptability of mammals; Some studies have shown that long-term exposure to high intensity magnetic field in mammals will appear insomnia, depression and immune function decline trend; At the same time, some studies have shown that the migration of turtles will be affected by the earth's magnetic field, which shows that the change of external magnetic environment will also have negative effects on marine organisms; According to the results of previous experiments, it also shows that extreme magnetic environment may have negative effects on the behavior of insects such as bees and ants; For human beings, long-term exposure to sub magnetic field environment will cause the weakening of vision and memory ability; This is likely to affect the cognitive ability of astronauts when performing extraterrestrial tasks; Strong magnetic field will affect the nervous system and skeletal system of the fetus in the womb of pregnant women, causing various congenital diseases of the fetus; In addition, in recent years, researchers have found that strong magnetic environment can continuously improve the proliferation of mouse osteoblasts; Through further research, it is found that strong magnetic environment increases the iron content in the cells during the proliferation of mouse osteoblasts; Further increasing the strong static magnetic field can significantly inhibit the differentiation of osteoclasts and affect the absorption activity of bone cells, leading to the gradual decrease of iron content and the gradual change of oxidative stress level in osteoclasts; As the above research, when the human body is in strong magnetic environment for a long time, it also shows that the physiological activity of bone cells is continuously improved, the death number of bone cells is continuously reduced, and the dimension of bone skeleton in bone cells is continuously improved, at the same time, the iron content in bone cells is enhanced; The above research results show that extreme magnetic environment will have different effects on most organisms; The outer space away from the geomagnetic field is a typical extreme magnetic environment; Therefore, in order to protect the space exploration of astronauts and the life safety of human beings in the future immigration process, we need to study the possible effects of extreme magnetic environment on human body first.

[0003] The past research on the extreme magnetic environment of human beings is limited to the short-term influence of the extreme magnetic environment on human beings or biological bodies, and the long-term influence of the extreme magnetic environment on biological bodies is not researched, which makes it difficult to truly reflect the changes of the bodies of astronauts in different extreme magnetic environments for a long time in the space or other magnetic fields of planets, and the past research has a very limited role in the future space exploration. Therefore, the application discloses a small animal independent ventilation non-magnetic cage negative pressure feeding system in an extreme magnetic environment. SUMMARY

[0004] The application aims to solve the problem of the lack of research on the long-term influence of the extreme magnetic environment on biological bodies, and introduces a negative pressure environment to ensure the biological safety during feeding. Therefore, the application combines an extreme magnetic environment generating coil and a small animal feeding cage technology to provide a stable feeding environment for long-term feeding of small animals by the extreme magnetic environment generating coil. The application aims to realize the feeding of small animals in an extreme magnetic environment for a long time and further explore the influence of the magnetic environment on biological bodies in subsequent research. According to the small animal independent ventilation non-magnetic cage negative pressure feeding system in an extreme magnetic environment, the application has at least the following beneficial effects: the extreme magnetic environment generating coil is used to provide a stable and variable external magnetic environment for the inside; the small animal feeding non-magnetic cage and the circulating air supply unit are used to independently provide a stable gas environment and living environment for small animals in each cage; and the negative pressure cover is used to improve the biological safety by preventing gas leakage during feeding.

[0005] According to the small animal independent ventilation non-magnetic cage negative pressure feeding system in an extreme magnetic environment, the application has at least the following beneficial effects: the extreme magnetic environment generating coil is used to provide a stable and variable external magnetic environment for the inside; the small animal feeding non-magnetic cage and the circulating air supply unit are used to independently provide a stable gas environment and living environment for small animals in each cage; and the negative pressure cover is used to improve the biological safety by preventing gas leakage during feeding.

[0006] According to some embodiments of the application, the stable magnetic environment is provided by a rectangular extreme magnetic environment generating coil.

[0007] According to some embodiments of the present application, the negative pressure environment is provided by a negative pressure hood cooperating with a gas line;

[0008] According to some embodiments of the present application, the small animal breeding environment is provided by a small animal breeding non-magnetic cage and a circulating gas supply unit;

[0009] According to some embodiments of the application, a small animal independent ventilation non-magnetic cage negative pressure feeding system in an extreme magnetic environment is implemented as follows: the extreme magnetic environment generating coil disclosed in the application is a square Helmholtz coil composed of coaxial square coils parallel to each other in X, Y and Z directions, the current directions in the two coils are consistent and the sizes are the same; the inside is a cubic space, and the whole extreme magnetic environment generating coil is built on a vibration isolation foundation; the extreme magnetic environment generating coil can be used to shield the external geomagnetic environment magnetic field and form a uniform extremely weak magnetic field in the internal space, or can be used to generate a strong magnetic field much higher than the geomagnetic environment; the negative pressure small animal feeding environment guarantee unit is mainly composed of a negative pressure cover, a small animal feeding non-magnetic cage inside the cover and a cage placing rack; the negative pressure cover is made of a layer of transparent film material (including but not limited to polystyrene, polypropylene, etc.) with an open middle opening sealed with a non-magnetic zipper, the non-magnetic cage rack is covered inside, and cooperates with the circulating air unit to form a negative pressure space to the atmospheric environment to prevent internal gas from leaking to the atmospheric environment, thus ensuring the biological safety of the external experimental conditions; the small animal feeding non-magnetic cage and the cage placing rack are designed and made for small animal feeding in an extreme magnetic environment, and the main feature of the small animal feeding non-magnetic cage and the cage placing rack compared with the ordinary cage and the cage placing rack on the market is that the whole small animal feeding non-magnetic cage and the cage placing rack are designed without magnetization, and high-strength non-magnetic materials are used to replace the iron materials used in traditional cages on the market to ensure that no new magnetic source is introduced in the feeding process; the non-magnetic materials selected for the small animal feeding non-magnetic cage and the cage placing rack include but are not limited to polyether ether ketone, phenolic cotton cloth board, etc.; the small animal feeding non-magnetic cage considers the comfort and health of small animals, has independent air inlet and outlet holes at the back to cooperate with the circulating ventilation unit to make the cage interior have good air flow, and can provide sufficient oxygen for small animals in feeding; in addition, the whole cage is easy to clean and maintain and is detachable; the circulating air unit disclosed in the application is composed of two independent circulating air paths, and is the most important part for taking and exhausting air in the cage and the negative pressure cover, and one or more fans can be used to provide air circulation and ventilation as needed; the circulating air unit is connected with the inside of the negative pressure cover through the negative pressure cover air inlet pipe and the negative pressure cover air outlet pipe, so that the circulating air unit can circulate and send air to the inside of the negative pressure cover; in addition, the circulating air unit is also connected with the inside of the cage placing rack through the cage air inlet pipe and the cage air outlet pipe to circulate and send air to the inside of the small animal feeding non-magnetic cage.The circulating air supply unit disclosed by the application can detect air quality in real time, including detecting the concentration of carbon dioxide, oxygen and nitrogen in air components, and can also detect air temperature and humidity, so that the detection parameters can ensure that the circulating air supplied is the most suitable gas environment for the survival and cultivation of small animals, and ensure the health of small animals during cultivation and the accuracy and reliability of experimental results. The air filtration and purification unit disclosed by the application mainly filters and purifies the waste gas in the circulating air supply unit. When the waste gas meets the emission standard, the gas is discharged outdoors, and harmful substances and dust in the waste gas are filtered out, so that the experiment does not pose a biochemical safety hazard to the outside world. Compared with the prior art, the application has the following characteristics.

[0010] (1) The extreme magnetic environment generating coil disclosed by the application can provide a stable and variable magnetic field inside, can shield the external geomagnetic environment, and can also provide a strong magnetic field inside which is much higher than the geomagnetic environment.

[0011] (2) The small animal feeding non-magnetic cage box, cage box placing rack, negative pressure cover, gas pipeline and the like disclosed by the application are all made of non-magnetic materials, which will not introduce additional magnetic field to ensure the extremely low magnetic signal inside during the extremely weak magnetic experiment.

[0012] (3) The circulating air supply unit disclosed by the application includes two independent gas circulation pipelines, which respectively provide independent air circulation for the inside of the small animal feeding cage box and the inside of the negative pressure cover, and cooperate with the cage box placing rack to ensure the independent ventilation between each small animal feeding cage box.

[0013] (4) The negative pressure environment disclosed by the application is provided by the negative pressure cover cooperating with the gas pipeline, which can ensure that the gas does not leak during the small animal feeding process, and further ensure the biochemical safety. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 It is a schematic diagram of a small animal independent ventilation non-magnetic cage feeding system in an extreme magnetic environment.

[0015] Part No. in the figure: 1-extreme magnetic environment generating coil, 2-negative pressure small animal feeding environment guarantee unit, 3-circulating air supply unit, 4-air purification unit.

[0016] Figure 2 It is a negative pressure small animal feeding environment guarantee unit.

[0017] Part No. in the figure: 2a-negative pressure cover, 2b-plastic wheel, 2c-non-magnetic cage placing rack outer frame structure, 2d-non-magnetic cage air inlet hole, 2e-non-magnetic cage air outlet hole, 2f-cage horizontal adjuster, 2g-back plate air outlet pipe, 2h-back plate air inlet pipe. DETAILED DESCRIPTION

[0018] Embodiments of the present application are described in detail below with reference to the attached drawing figures, wherein the same or like component have the same or similar designations. The embodiments described below are presented by way of example only and are not intended to limit the present application as defined by the appended claims. In the description of the present application, it is to be understood that the orientation or positional relationship, such as up, down, bottom, etc., indicated by the terms described herein are based on the orientation or positional relationship shown in the drawings, and are merely for the purpose of facilitating the description of the present application and simplifying the description, and therefore cannot be construed as indicating or implying that the device or element indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be construed as limiting the present application. In the description of the present application, the term "a plurality of" means two or more. If the terms "first", "second", etc. are used in the description of the present application, they are used only for the purpose of distinguishing technical features for the purpose of distinguishing technical features, and cannot be construed as indicating or implying relative importance or implying the number of technical features indicated or the order of technical features indicated. In the description of the present application, the terms "arrange", "mount", "connect", etc. should be interpreted broadly, and the skilled person in the art can determine the specific meaning of the above terms in the present application in combination with the specific content of the technical solution.

[0019] The present application will be further described in detail below with reference to the accompanying drawings:

[0020] Reference Figure One For a small animal independent ventilation non-magnetic cage negative pressure feeding system principle diagram in an extreme magnetic environment; by Figure One It can be seen that the main body of the small animal independent ventilation non-magnetic cage negative pressure feeding system disclosed in the present application is composed of an extreme magnetic environment generating coil, a negative pressure cover, a small animal feeding non-magnetic cage box and a cage box placing rack, a circulating air supply unit, and an air purification unit. The extreme magnetic environment generating coil is a square Helmholtz coil composed of coaxial square coils parallel to each other and connected in X, Y, and Z axial directions, and the current directions and sizes inside the two coils are the same. According to the reference Figure One It can be seen that the extreme magnetic environment generating coil inside is a cube space, and the whole is built on a vibration isolation foundation. According to the reference Figure One The extreme magnetic environment generating coil of the extreme magnetic environment generating coil in use can be used to shield the external geomagnetic environment magnetic field, form a uniform extremely weak magnetic field in the internal space, and also can be used to generate a strong magnetic field much higher than the geomagnetic environment.

[0021] According to the reference Figure TwoIt can be seen that the negative pressure small animal feeding environment guarantee unit is mainly composed of a negative pressure cover and a small animal feeding non-magnetic cage box and a cage box placing rack inside the negative pressure cover; wherein, the negative pressure cover is made of a layer of transparent film material (the material includes but is not limited to polystyrene, polypropylene, etc.) with an open middle opening sealed with a non-magnetic zipper; the non-magnetic cage rack is covered inside, cooperates with the circulating air unit to form a negative pressure space to the atmospheric environment to prevent internal gas from leaking to the atmospheric environment, so as to ensure the biological safety of the atmospheric environment in the external experimental conditions; the small animal feeding non-magnetic cage box and the cage box placing rack are designed and made for long-term feeding of small animals in an extreme magnetic environment; compared with the existing ordinary cage box and cage box placing rack on the market, the main feature of the small animal feeding non-magnetic cage box and cage box placing rack disclosed by the application is that the whole is designed without magnetization, and high-strength non-magnetic material is used to replace the iron material used in the traditional cage box on the market, so that a new magnetic source is not introduced into the environment during feeding, and the non-magnetic material selected for the small animal feeding non-magnetic cage box and cage box placing rack disclosed by the application includes but is not limited to polyether ether ketone, phenolic cotton cloth board, etc.; the small animal feeding non-magnetic cage box considers the comfort and health of small animals, and has independent air inlet and air outlet holes at the rear to cooperate with the circulating air unit to make the cage box have good air flow, and can provide sufficient oxygen for small animals during feeding; in addition, the whole cage box is easy to clean and maintain and is detachable. Figure One It can be seen that the circulating air supply unit disclosed by the application is composed of two independent circulating air paths, and the circulating air supply unit is the most important part for taking and exhausting air in the cage box and the negative pressure cover in the extreme magnetic environment, and one or more fans can be used to provide air circulation and ventilation as needed; the circulating air supply unit is connected with the inside of the negative pressure cover through the negative pressure cover air inlet pipe and the negative pressure cover air outlet pipe, so that the circulating air supply unit can circulate and supply air to the inside of the negative pressure cover; in addition, the circulating air supply unit is also connected with the inside of the cage box placing rack through the cage box air inlet pipe and the cage box air outlet pipe to circulate and supply air to the inside of the small animal feeding non-magnetic cage box. The circulating air supply unit disclosed by the application can detect the air quality in real time, including detecting the concentration of carbon dioxide, oxygen and nitrogen in the air composition, and also can detect the temperature and humidity of the air, so that the detected parameters can ensure that the circulating air is the most suitable gas environment for small animal survival and culture, and ensure the health of small animals during culture and the accuracy and reliability of experimental results; the air filtration and purification unit disclosed by the application mainly filters and purifies the waste gas in the circulating air supply unit, and discharges the gas outside when the waste gas meets the emission standard, so as to filter out harmful substances and dust in the waste gas and prevent biochemical safety hazards to the outside.

Claims

1. A negative pressure rearing system for small animals in independently ventilated, non-magnetic cages in extreme magnetic environments, characterized in that, It includes the following parts: Extreme magnetic environment generating coil (1); Negative pressure small animal breeding environment (2); Non-magnetic cages and cage display racks for small animals; Circulating air supply unit (3); Air purification unit (4); The extreme magnetic environment generating coil (1) is a square Helmholtz coil consisting of coaxial square coils that are parallel and connected to each other in the X, Y, and Z directions. The current in the two coils is in the same direction and has the same magnitude. The interior is a cubic space. The extreme magnetic environment generating coil (1) is built on a vibration isolation foundation. The negative pressure small animal breeding environment (2) is composed of a negative pressure cover, a non-magnetic cage box for small animal breeding, and a cage box placement rack. The negative pressure cover is made of a transparent film. The negative pressure cover covers the entire non-magnetic cage box for small animal breeding and the cage box placement rack and is sealed with a zipper. Air is vented into the negative pressure cover through the ventilation pipe to keep the air pressure inside the negative pressure small animal breeding environment (2) lower than the external atmospheric pressure, thereby ensuring that the gas inside the negative pressure cover will not leak into the indoor space.

2. The negative pressure feeding system for small animals in independently ventilated, non-magnetic cages in extreme magnetic environments as described in claim 1, characterized in that: The circulating air supply unit (3) and the air purification unit (4) are connected by an exhaust gas pipeline. The air purification unit (4) purifies the exhaust gas generated inside the circulating air supply unit (3) to a level that can be discharged and then discharges it outdoors.

3. The negative pressure feeding system for small animals in independently ventilated, non-magnetic cages in extreme magnetic environments as described in claim 1, characterized in that: The circulating air supply unit (3) consists of two independent circulating air paths. The circulating air supply unit (3) is connected to the negative pressure small animal breeding environment (2) through the negative pressure hood air inlet pipe and the negative pressure hood air outlet pipe to circulate air inside the negative pressure hood. In addition, the circulating air supply unit (3) is also connected to the cage box placement rack through the cage box air inlet pipe and the cage box air outlet pipe to circulate air inside the non-magnetic cage box for small animal breeding.

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