Cardiac rupture early warning cardiovascular intervention detection device based on fiber raman spectroscopy

Abstract

The application discloses a kind of heart rupture early warning cardiovascular intervention detection devices based on optical fiber Raman spectrum, including laser emission device, optical filter system, optical fiber probe, optical spectrum instrument and CCD detection device, the laser emission device is connected to the optical filter system by first optical fiber, the optical fiber probe is connected to the optical filter system by second optical fiber and third optical fiber, the inlet of the optical spectrum instrument is connected to the optical filter system by fourth optical fiber, the first optical fiber and second optical fiber are correspondingly arranged on the left and right sides of the optical filter system, the third optical fiber and fourth optical fiber are correspondingly arranged on the left and right sides of the optical filter system, the outlet of the optical spectrum instrument is installed the CCD detection device, and the CCD detection device is used to connect computer system to enable computer system to generate the characteristic spectrum of detection. Real-time, non-invasive detection and monitoring in the treatment process are realized.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of heart intervention detection, and particularly relates to a heart rupture early warning cardiovascular intervention detection device based on optical fiber Raman spectrum. BACKGROUND

[0002] Cardiac rupture (CR) is the most severe complication of acute myocardial infarction (AMI), and is commonly seen within 5 days after the onset of AMI, and is most common within 1 day after the onset. The risk of CR is higher in patients with initial AMI. In addition, persistent tension, premature activity or labor, delayed medical treatment or certain anticoagulant or thrombolytic drugs can all trigger CR. After the occurrence of cardiac rupture, there is a lack of treatment means. Once a patient has a cardiac rupture, most of them have no treatment opportunities, and emergency surgical treatment is currently the only treatment means, but surgical treatment also faces great difficulties. Previous studies have found that only about 1 / 5 of patients diagnosed with CR have received surgical treatment. Secondly, the surgical risk is high, and the postoperative prognosis is still poor. Studies have found that more than 30% of patients still die in hospital even after emergency surgery. In addition, there is controversy over the timing of surgery, and early or late surgery can cause adverse prognosis due to excessive myocardial fragility or iatrogenic enlargement of the rupture area.

[0003] In related technologies, the materials known at present related to the pathogenic characteristics and risk factors of cardiac rupture are mostly from retrospective observational studies or case reports, and are mostly irreversible factors (such as: advanced age, female, myocardial infarction site, etc.) and lack specificity. Genes and blood markers are indirect prediction indicators, and their sensitivity and specificity still need to be further improved. Studies have found that the myocardium of patients will undergo corresponding pathological changes after the onset of AMI, and there is almost no current imaging detection means. AMI patients generally need to undergo heart intervention surgery, and myocardial intervention detection can be performed at the same time as heart intervention surgery.

[0004] In summary, the acute and critical condition of cardiac rupture currently still lacks early warning pathological indicators, and therefore, if the prediction of cardiac rupture after AMI is to be achieved, a new method capable of directly and early evaluating the pathological change process leading to cardiac rupture needs to be developed. SUMMARY

[0005] To solve at least one of the problems mentioned in the background, the purpose of the present application is to provide a heart rupture early warning cardiovascular intervention detection device based on optical fiber Raman spectrum.

[0006] The present application is achieved by the following technical solutions:

[0007] A cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy includes a laser emitting device, a filtering system, a fiber optic probe, a spectrometer, and a CCD detection device. The laser emitting device is connected to the filtering system via a first optical fiber, and the fiber optic probe is connected to the filtering system via a second and a third optical fiber. The inlet of the spectrometer is connected to the filtering system via a fourth optical fiber. The first and second optical fibers are respectively disposed on the left and right sides of the filtering system, and the third and fourth optical fibers are respectively disposed on the left and right sides of the filtering system. The CCD detection device is installed at the outlet of the spectrometer. The CCD detection device is used to connect to a computer system so that the computer system can generate the characteristic spectrum of the detection. The fiber optic probe is used to irradiate the surface of the myocardial cells being tested with the laser emitted by the laser emitting device to induce Raman scattering and to collect the reflected Raman scattered light.

[0008] In one embodiment, the laser emitting device is a laser.

[0009] In one embodiment, the laser is a 785nm diode laser.

[0010] In one embodiment, the filtering system is a fiber optic grating filtering system, and the filtering system has four fiber optic interfaces on its left and right sides for connecting the first fiber, the second fiber, the third fiber, and the fourth fiber.

[0011] In one embodiment, the filtering system includes an ultra-narrow band filter and a bandpass filter. The first and second optical fibers are located on either side of the ultra-narrow band filter. The ultra-narrow band filter can transmit laser light with a wavelength of 785 nm. The bandpass filter is located below the ultra-narrow band filter, and the third and fourth optical fibers are located on either side of the bandpass filter. The bandpass filter can block the transmission of laser light with a wavelength of 785 nm.

[0012] In one embodiment, the fiber optic probe includes a central Raman excitation fiber and multiple Raman collection fibers. The central Raman excitation fiber is clad with a polyimide shell. When the second fiber is connected to the fiber optic probe, it is docked with the central Raman excitation fiber. The central Raman excitation fiber is used to irradiate the surface of the cardiomyocytes being tested with laser light to induce Raman scattering. Multiple Raman collection fibers are evenly distributed around the central Raman excitation fiber to collect the reflected Raman scattered light.

[0013] In one embodiment, one of the multiple Raman collecting optical fibers is equipped with a stress sensor for stress collection, and another is equipped with a temperature sensor for temperature collection.

[0014] In one embodiment, there are a total of eight Raman collecting fibers, six of which are used to collect reflected Raman scattered light, and two of which are used for stress collection and temperature collection, respectively.

[0015] In one embodiment, the spectrometer is a scientific-grade Ocean Optics QE65PRO-RAMAN spectrometer, and the CCD detection device is a Hamamatsu S7031-1006.

[0016] In one embodiment, a computer is also included, and the CCD detection device is connected to the computer.

[0017] The beneficial effects of the present invention are as follows: The cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy of the present invention solves at least one technical problem existing in the prior art and achieves the beneficial effects of combining fiber Raman spectroscopy detection technology with cardiac interventional methods to complete the pathological detection of myocardial tissue after AMI, thereby achieving the early warning effect of cardiac rupture (CR) and realizing real-time, non-invasive detection and monitoring in the body during the treatment process. Attached Figure Description

[0018] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0019] Figure 1 This is an overall schematic diagram of a cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy according to an embodiment of the present invention.

[0020] Figure 2 This is a schematic diagram of the implementation architecture of a cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy according to an embodiment of the present invention.

[0021] Figure 3 This is a schematic diagram of the fiber optic probe of a cardiovascular interventional detection device for early warning of cardiac rupture based on fiber optic Raman spectroscopy, according to an embodiment of the present invention.

[0022] Figure 4 This is a schematic diagram of the fiber optic probe of a cardiovascular interventional detection device for early warning of cardiac rupture based on fiber optic Raman spectroscopy, according to an embodiment of the present invention;

[0023] Among them, 1. Computer, 2. Laser emitting device, 3. First optical fiber, 4. Spectrometer, 5. Fourth optical fiber, 6. Third optical fiber, 7. Second optical fiber, 8. Optical fiber probe, 81. Central Raman excitation fiber, 82. Polyimide cladding, 83. Raman collecting fiber, 84. Temperature sensor, 85. Stress sensor, 9. CCD detection device, 10. Filtering system. Detailed Implementation

[0024] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0025] In the description of the embodiments of the present invention, it should be understood that the terms "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of the present invention.

[0026] The following is for reference Figures 1-4 The embodiments of the present invention will be described in detail regarding the cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy.

[0027] It should be noted that AMI patients generally require interventional cardiac surgery. During this surgery, interventional myocardial detection can be performed simultaneously. Raman spectroscopy is non-invasive for in vivo detection and possesses fingerprint molecular characteristics, making it highly suitable for interventional myocardial detection. Currently, early warning pathological indicators are lacking for acute and critical conditions like cardiac rupture. Therefore, to predict cardiac rupture after AMI, new methods need to be developed to directly assess the pathological changes leading to cardiac rupture at an early stage. Raman spectroscopy, with its high fingerprint molecular characteristics and non-invasive in vivo detection, is a very suitable detection method. Therefore, this embodiment provides a cardiovascular interventional detection device for early warning of cardiac rupture based on fiber optic Raman spectroscopy.

[0028] like Figures 1-4 As shown, the cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy according to an embodiment of the present invention includes a laser emitting device 2, a filtering system 10, a fiber optic probe 8, a spectrometer, and a CCD detection device 9. The laser emitting device 2 is connected to the filtering system 10 through a first fiber 3. The fiber optic probe 8 is connected to the filtering system 10 through a second fiber 7 and a third fiber 6. The inlet of the spectrometer 4 is connected to the filtering system 10 through a fourth fiber 5. The first fiber 3 and the second fiber 7 are respectively disposed on the left and right sides of the filtering system 10. The third fiber 6 and the fourth fiber 5 are respectively disposed on the left and right sides of the filtering system 10. The CCD detection device 9 is installed at the outlet of the spectrometer 4. The CCD detection device 9 is used to connect to a computer system 1 so that the computer system 1 generates the characteristic spectrum of detection. The fiber optic probe 8 is used to irradiate the surface of the myocardial cells to be tested with the laser emitted by the laser emitting device 2 to cause Raman scattering and to collect the reflected Raman scattered light.

[0029] Here, the laser emitting device 2 can be any type of laser; the appropriate wavelength can be selected based on the actual scenario. The filtering system 10 is a device for filtering stray light other than the laser beam. Therefore, the filtering system 10 should be able to transmit the corresponding wavelength of laser light. Simultaneously, when collecting Raman scattered light, the filtering system 10 also needs to filter other light besides Raman scattered light, such as the machine light beam that directly reflects into the fiber optic probe 8. The spectrometer 4 and CCD detection device 9 can be selected according to the actual scenario. The spectrometer 4 splits the Raman light, and then the scattered light is detected by the CCD detection device 9 (e.g., a charge-coupled device (CCD) detector). The CCD detection device 9 converts the optical signal into an electrical signal and transmits it to the computer 1. The host computer software on the computer 1 performs data preprocessing on the obtained spectral data to achieve the identification of the measured target tissue spectrum. The first optical fiber 3, the second optical fiber 7, the third optical fiber 6, and the fourth optical fiber 5 can be selected from optical fibers with high transmission efficiency.

[0030] Therefore, at least one technical problem existing in the background technology is solved, and beneficial effects are achieved: by combining fiber optic Raman spectroscopy detection technology with cardiac interventional methods, myocardial tissue pathological examination after AMI is completed, thereby achieving the early warning effect of cardiac rupture (CR), and realizing real-time, non-invasive detection and monitoring in the body during the treatment process.

[0031] In one embodiment, the laser emitting device 2 is a laser. The laser is a 785nm diode laser, for example, a spectrally stable 785nm diode laser with a maximum output of 300mW can be selected, and its model can be FC-D-785nm.

[0032] In one embodiment, the filtering system 10 is a fiber optic grating filtering system, and the filtering system 10 has four fiber optic interfaces on its left and right sides for connecting the first fiber 3, the second fiber 7, the third fiber 6, and the fourth fiber 5. This facilitates the connection of the optical fibers, while achieving efficient transmission of the initial laser and collection of clean Raman scattered light, reducing noise data, and improving detection accuracy.

[0033] For example, the filtering system 10 includes an ultra-narrowband filter and a bandpass filter. The first optical fiber 3 and the second optical fiber 7 are located on either side of the ultra-narrowband filter. The ultra-narrowband filter can transmit laser light with a wavelength of 785 nm. The bandpass filter is located below the ultra-narrowband filter, and the third optical fiber 6 and the fourth optical fiber 5 are located on either side of the bandpass filter. The bandpass filter can block the transmission of laser light with a wavelength of 785 nm. Here, the ultra-narrowband filter can only transmit laser light with a wavelength of 785 nm, thereby filtering out stray light in the incident 785 nm laser light and ensuring that the emitted light has a wavelength of 785 nm, thus ensuring that the subsequent Raman scattering effect forms uniform Raman scattered light. The bandpass filter can block the transmission of 785nm laser light, thereby filtering out the 785nm laser light reflected back from the object surface mixed in with the Raman scattered light transmitted from the fiber optic probe 8. This improves the purity of the Raman scattered light transmitted to the spectrometer 4, thereby enhancing the accuracy of subsequent data analysis and achieving higher detection precision.

[0034] In one embodiment, the fiber optic probe 8 includes a central Raman excitation fiber 81 and multiple Raman collecting fibers 83. The central Raman excitation fiber 81 is encased in a polyimide shell 82. When the second fiber 7 is connected to the fiber optic probe 8, it is mated with the central Raman excitation fiber 81. The central Raman excitation fiber 81 is used to diffuse laser light onto the surface of the cardiomyocytes being tested, causing Raman scattering. Multiple Raman collecting fibers 83 are evenly distributed around the central Raman excitation fiber 81 to collect the reflected Raman scattered light. Among the multiple Raman collecting fibers 83, one is equipped with a stress sensor 85 for stress collection, and another is equipped with a temperature sensor 84 for temperature collection.

[0035] In one embodiment, there are a total of eight Raman collecting fibers 83, six of which are used to collect reflected Raman scattered light, and two of which are used for stress collection and temperature collection, respectively.

[0036] In one embodiment, the spectrometer 4 is a scientific-grade spectrometer 4 Ocean Optics QE65PRO-RAMAN, and the CCD detection device 9 can be a charge-coupled device (CCD) detector, model Hamamatsu S7031-1006.

[0037] Furthermore, it also includes a computer 1, to which the CCD detection device 9 is connected.

[0038] Therefore, the cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy in this application embodiment uses a 785nm laser as the excitation source. The laser passes through the fiber optic probe 8 to excite the Raman scattered light of the myocardial tissue in front of the probe. The Raman scattered light enters the spectrometer 4 through the collecting fiber in the fiber optic probe 8. The spectrometer 4 splits the Raman light, and then the scattered light is detected by the charge-coupled device (CCD) detector. The detector converts the optical signal into an electrical signal and transmits it to the computer 1. The host computer software performs data preprocessing on the obtained spectral data to realize the identification of the spectrum of the target tissue.

[0039] Specifically, the cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy in this application includes, in terms of hardware, a laser, a fiber optic grating filter system 10, four optical fibers, a bundled fiber optic probe 8, a spectrometer 4, and a CCD detector. Regarding the light source, a 785nm wavelength light source is used as the excitation source. Its advantages are that, based on a silicon-based CCD detector, it can achieve low absorption, deep penetration, low fluorescence interference, and reasonable quantum efficiency, and can measure wavelengths up to 3500 cm⁻¹. -1 The Raman shift. Compared to light sources with wavelengths of 830nm or 1064nm, the 785nm excitation source reduces tissue fluorescence while ensuring the intensity of Raman scattering. The fiber optic probe 8 uses low-OH-bond silica fiber, with a polyimide cladding material, and incorporates corresponding fiber optic sensing devices for real-time monitoring of ambient temperature and probe tip stress. It can also acquire information about the environment of the probed tissue for spectral correction. The internal structure of the fiber optic probe 8 is shown in the diagram below. Figure 3 The cross-sectional diagram of the probe is shown below. Figure 4 As shown. During interventional cardiac testing, the fiber optic probe 8 enters the aorta along the artery of the upper limb and then into the heart to complete the detection of myocardial tissue.

[0040] In this embodiment, the overall operation process for cardiac interventional testing is as follows: the laser is turned on, and the light emitted by the light source enters the fiber optic grating filtering system 10 along the first fiber optic cable 3 to filter out stray light and ensure that only a single wavelength of 785nm light is emitted. The emitted light is transmitted along the second fiber optic cable 7 to the fiber optic probe 8, and then irradiates the surface of the myocardial cells being tested, resulting in Raman scattering. The Raman scattered light is collected by the Raman collecting fiber 83 in the bundle of the fiber optic probe 8, and transmitted to the fiber optic grating filtering system 10 via the third fiber optic cable 6. After the stray light is filtered, it is transmitted to the spectrometer 4 via the fourth fiber optic cable 5 to complete the spectral splitting. After spectral splitting, the light irradiates the CCD detector, which is connected to the host computer system in the computer 1. Finally, the characteristic spectrum of the target cardiac tissue is obtained in the host computer software, and the Raman spectral detection of the myocardium is completed.

[0041] Therefore, the cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy provided in this embodiment of the invention solves at least one technical problem existing in the prior art and achieves beneficial effects: by combining fiber Raman spectroscopy detection technology with cardiac interventional methods, the pathological examination of myocardial tissue after AMI is completed, thereby achieving the early warning effect of cardiac rupture (CR), and realizing real-time, non-invasive detection and monitoring in the body during the treatment process.

[0042] In the description of this invention, the terms "first," "second," "another," and "yet another" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the stated features. In the description of embodiments of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0043] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances. Furthermore, in the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0044] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A cardiovascular interventional detection device for early warning of cardiac rupture based on fiber optic Raman spectroscopy, characterized in that, The device includes a laser emitting device, a filtering system, an optical fiber probe, a spectrometer, and a CCD detection device. The laser emitting device is connected to the filtering system via a first optical fiber. The optical fiber probe is connected to the filtering system via a second and a third optical fiber. The entrance of the spectrometer is connected to the filtering system via a fourth optical fiber. The first and second optical fibers are respectively positioned on the left and right sides of the filtering system, and the third and fourth optical fibers are respectively positioned on the left and right sides of the filtering system. The CCD detection device is installed at the exit of the spectrometer. The CCD detection device is used to connect to a computer system so that the computer system can generate the characteristic spectrum of the detection. The optical fiber probe is used to irradiate the surface of the cardiomyocytes being tested with the laser emitted by the laser emitting device, causing Raman scattering, and collecting the reflected Raman scattered light. The filtering system is a fiber optic grating filtering system. Four fiber optic interfaces for connecting the first, second, third, and fourth optical fibers are provided on the left and right sides of the filtering system. The filtering system includes an ultra-narrowband filter and a bandpass filter. The first and second optical fibers are located on either side of the ultra-narrowband filter. The ultra-narrowband filter can transmit laser light with a wavelength of 785 nm. The bandpass filter is located below the ultra-narrowband filter, and the third and fourth optical fibers are located on either side of the bandpass filter. The bandpass filter can block the transmission of laser light with a wavelength of 785 nm. The fiber optic probe includes a central Raman excitation fiber and multiple Raman collecting fibers. The central Raman excitation fiber is clad in polyimide. When the second fiber is connected to the fiber optic probe, it is docked with the central Raman excitation fiber. The central Raman excitation fiber is used to diffuse laser light onto the surface of the cardiomyocytes being tested, causing Raman scattering. Multiple Raman collecting fibers are evenly distributed around the central Raman excitation fiber to collect the reflected Raman scattered light. Among the multiple Raman collecting fibers, one is equipped with a stress sensor for stress collection, and another is equipped with a temperature sensor for temperature collection. There are a total of eight Raman collecting fibers, six of which are used to collect the reflected Raman scattered light, and two of which are used for stress collection and temperature collection, respectively.

2. The cardiovascular interventional detection device for early warning of cardiac rupture based on fiber optic Raman spectroscopy according to claim 1, characterized in that, The laser emitting device is a laser.

3. The cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy according to claim 2, characterized in that, The laser is a 785nm diode laser.

4. The cardiovascular interventional detection device for early warning of cardiac rupture based on fiber Raman spectroscopy according to claim 1, characterized in that, The spectrometer is a scientific-grade Ocean Optics QE65PRO-RAMAN, and the CCD detector is a Hamamatsu S7031-1006.

5. The cardiovascular interventional detection device for early warning of cardiac rupture based on fiber optic Raman spectroscopy according to any one of claims 1-4, characterized in that, It also includes a computer, to which the CCD detection device is connected.

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