An analytical liquid chromatography column

Abstract

The application discloses the technical field of liquid chromatography column, and particularly relates to an analytical liquid chromatography column, which comprises a chromatography column, which can distribute and place each component substance of a mixture, a self-locking device, which is arranged at the two ends of the outer wall of the chromatography column and can cooperate with a sealing device to seal the two ends of the chromatography column, the sealing device, which is screw-connected at the two ends of the outer wall of the chromatography column and can seal the two ends of the chromatography column, and a clamping device, which is arranged around the sealing device and clamps the self-locking device, and can drive the self-locking device and the sealing device to rotate to tightly seal the two ends of the chromatography column. The application can conveniently disassemble and replace the inner cavity, thereby reducing the maintenance and replacement time, facilitating the replacement and alternating use of the inner cavity, saving time and labor and being simple and convenient to operate when fastening, and the sealing device can be more conveniently fastened, thereby increasing the detection efficiency.

Description

Technical Field

[0001] This invention relates to the field of liquid chromatography column technology, specifically to an analytical liquid chromatography column. Background Technology

[0002] A liquid chromatography column is an instrument used for liquid chromatography analysis, consisting of column tubes, pressure caps / ferrules, sieve plates / filters, etc.

[0003] Liquid chromatography (LC) is a physical or physicochemical separation and analysis method, particularly suitable for separating multi-component samples. It is one of the most efficient and widely used separation techniques. Its principle is based on the fact that the components of a mixture have different partition coefficients in two phases. When the two phases move relative to each other, these substances undergo repeated partitioning to achieve separation. As the site and tool for chromatographic separation, the performance of the LC column fundamentally determines the separation effect. Commonly used LC columns are filled with fine-particle-size packing to obtain high resolution. However, the fluid resistance of fine-particle-size packing is often very high, and a high-pressure pump must be used to force the mobile phase through the column. Therefore, the chromatographic column itself must have good pressure resistance and sealing performance.

[0004] Existing chromatographic column structures on the market typically use a line seal connection with a conical sleeve. This sealing structure has high processing requirements, is expensive, and requires considerable effort to connect and seal, necessitating the use of significant force to tightly secure the nuts to both ends of the chromatographic column to ensure sealing performance. To address this, we propose an analytical liquid chromatography column. Summary of the Invention

[0005] In view of the problems existing in the above and / or existing analytical liquid chromatography columns, the present invention is proposed.

[0006] Therefore, the purpose of this invention is to provide an analytical liquid chromatography column that, by holding an external drive device and inserting it into the outer wall of a sealing device, drives the sealing device to clamp the self-locking device. After clamping, the self-locking device and the sealing device are rotated for secondary tightening, thus solving the aforementioned problems.

[0007] To address the aforementioned technical problems, according to one aspect of the present invention, the present invention provides the following technical solution:

[0008] An analytical liquid chromatography column comprising:

[0009] A chromatographic column is used to distribute and position the components of a mixture.

[0010] The self-locking device is located at both ends of the outer wall of the chromatographic column and can cooperate with the sealing device to seal both ends of the chromatographic column.

[0011] A sealing device, which is threadedly connected to both ends of the outer wall of the chromatographic column and can seal both ends of the chromatographic column;

[0012] The clamping device is arranged around the sealing device and clamps the self-locking device. At the same time, it can drive the self-locking device and the sealing device to rotate, so as to tighten and seal both ends of the chromatographic column.

[0013] An external drive unit is detachably mounted on the outer wall of the sealing device and can drive the sealing device to rotate, thereby driving the clamping device to perform clamping and rotation operations.

[0014] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the chromatographic column comprises:

[0015] An outer cavity assembly, the interior of which can accommodate an inner cavity assembly;

[0016] The first limiting component is disposed around the inner wall of the outer cavity component and is capable of squeezing the periphery of the inner cavity component.

[0017] The second limiting component is disposed around the inner wall of the outer cavity component and is staggered with the first limiting component, and can limit the placement of the inner cavity component.

[0018] The internal cavity assembly has two ends that allow for the distribution and placement of the various components of the mixture.

[0019] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the external cavity assembly includes:

[0020] The outer cavity allows for the placement of the inner cavity components.

[0021] External cavity threads are located at both ends of the outer wall of the external cavity and can be used to connect the sealing device.

[0022] The first limiting component includes:

[0023] The first limiting plate is disposed around the inner wall of the outer cavity assembly;

[0024] The pressing plate is slidably connected inside the first limiting plate, and its outer side is pressed against the outer wall of the inner cavity assembly.

[0025] A spring, one end of which is connected to the inner side of the pressing plate and the other end of which is connected to the inside of the first limiting plate, is capable of pushing the pressing plate out.

[0026] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the second limiting component includes:

[0027] The second limiting plate is disposed around the inner wall of the outer cavity assembly and is staggered with the first limiting plate.

[0028] The limiting groove is located inside the second limiting plate and is internally slidably connected to the outer wall of the inner cavity assembly.

[0029] The cavity assembly includes:

[0030] The inner cavity is detachably installed inside the outer cavity;

[0031] The recessed groove is located around the outer wall of the inner cavity and is slidably connected to the pressing plate inside, and can be squeezed by the pressing plate.

[0032] The limiting block is set around the outer wall of the inner cavity and is placed alternately with the inner groove, and is slidably connected to the inside of the second limiting plate.

[0033] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the self-locking device includes:

[0034] The self-locking assembly is located at both ends of the outer wall of the outer cavity;

[0035] The tapping assembly is threaded onto the outer wall of the self-locking assembly and is held by the clamping device, so that the sealing device is tightly connected to both ends of the outer cavity.

[0036] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the self-locking component includes:

[0037] The I-shaped sleeve is set at both ends of the outer wall of the outer cavity;

[0038] The inner groove is located in the middle of the outer wall of the I-beam sleeve;

[0039] The self-locking thread is set around the outer wall of the inner groove, and the outer wall thread is connected to the tapping assembly;

[0040] The tapping assembly includes:

[0041] The tapping nut has internal tapping threads, and the tapping nut is connected to the self-locking thread through the tapping threads, so that the tapping nut can move between the inner grooves of the I-beam sleeve;

[0042] The clamping groove is located around the outer wall of the tapping nut and can be clamped and fixed by the clamping device.

[0043] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the sealing device includes:

[0044] A sealing assembly, whose threaded connection is located at the external cavity thread, and which can seal both the external and internal cavities at their respective ports;

[0045] The movable component is rotatably connected to the center of the outer wall of the sealing component and is capable of driving the clamping of the clamping device;

[0046] A support assembly is connected to the outside of the sealing assembly, and a central rotating connection between the support assembly and the sealing assembly is made between the support assembly and the sealing assembly.

[0047] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the sealing assembly includes:

[0048] The sealing cap has an internal thread on its inner wall, which connects with the external cavity thread, and the sealing cap can seal the two sides of the external cavity and the inner cavity.

[0049] The compression plug is located inside the center of the sealing cap and is designed in an I-shape. It is inserted into the two side ports of the outer cavity and compresses the two side ports of the inner cavity, thereby sealing the two side ports of the inner cavity.

[0050] The plug is located at the outer port of the squeeze plug and is inserted into the two side ports of the inner cavity, thereby sealing the two side ports of the inner cavity.

[0051] The active components include:

[0052] The screw is rotatably connected at the center of the sealing cap and the bracket assembly;

[0053] The movable block is threadedly connected to the outer wall of the screw.

[0054] The protruding post is located around the outer wall of the movable block and can be connected to the clamping device, and can drive the clamping device to perform clamping operation.

[0055] The support assembly includes:

[0056] The limiting plate has a limiting bracket around its inner wall, and the other end of the limiting bracket is connected to the outer wall of the sealing cap.

[0057] The positioning groove is set around the outer wall of the limiting plate and can be used to position the connection of the external drive device.

[0058] The drive slot is located at the center of the limiting plate, and the outer port of the screw is inserted inside it.

[0059] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the clamping device includes:

[0060] The clamping block is clamped around the inside of the clamping groove;

[0061] The guide rod has one end rotatably connected to both ends of the inner side of the outer wall of the clamping block, and the other end rotatably connected to both ends of the outer wall of the first guide shaft seat.

[0062] The first guide shaft seat is disposed around the outer wall of the sealing cap;

[0063] The folding rod has one end rotatably connected to both ends of the outer wall of the clamping block, the middle end rotatably connected to both ends of the outer wall of the second guide shaft seat, and the end rotatably connected to both ends of the outer wall of the drive connecting rod.

[0064] The second guide shaft seat is disposed around the outer wall of the sealing cap and placed outside the first guide shaft seat;

[0065] The drive connecting rod has one end rotatably connected to the folding rod and the other end rotatably connected to the outer wall of the protruding column, and can be driven by the protruding column, thereby driving the clamping block to perform clamping operations.

[0066] As a preferred embodiment of the analytical liquid chromatography column described in this invention, the driving device includes:

[0067] The drive motor is located on the outer wall of the mounting plate and can be detachably mounted on the outside of the sealing device;

[0068] Positioning posts are set around the inner wall of the mounting plate and can be inserted into the positioning slot to position the mounting plate during installation.

[0069] The drive rod has one end connected to the output end of the drive motor, and the other end passes through the center of the mounting plate and the drive groove, and is inserted into the inside of the screw, and can drive the screw to rotate.

[0070] Compared with existing technologies:

[0071] By designing and coordinating the first limiting component and the second limiting plate of the chromatographic column, the inner cavity can be securely placed inside the outer cavity, thereby preventing the inner cavity from shaking. At the same time, it allows for easy disassembly and replacement of the inner cavity, thereby reducing maintenance and replacement time, facilitating the alternation of inner cavities, and increasing the efficiency of detection experiments.

[0072] By cooperating with the self-locking device, the sealing device, and the clamping device, the clamping device can clamp the self-locking device, compressing and sealing the outer and inner cavities of the sealing device. After clamping, the continuous rotation of the clamping device causes the sealing device and the tapping nut to rotate simultaneously, thus tightening the threads of the sealing device. This increases the compression force on the outer and inner cavities, enhances their sealing performance, and ensures that the inner cavity maintains a high air pressure, facilitating testing operations.

[0073] The clamping device is driven by the screw, which moves the movable block and the protrusion, thereby clamping the clamping block inside the clamping groove. This causes the sealing cap to be squeezed between the outer and inner cavities. When the movable block moves to the bottom, it contacts the sealing cap, generating a large frictional force, which tightens the screw and prevents it from rotating. When the screw is rotated again, it will drive the sealing cap and the clamping block to rotate simultaneously, and at the same time, it will drive the tapping nut to be threaded onto the self-locking thread of the I-beam sleeve, thus achieving secondary tightening and increasing the sealing and airtightness of the inner cavity.

[0074] By holding the external drive device, place it on the surface of the limiting plate, insert the positioning pin into the positioning groove, and insert the drive rod into the drive groove. By starting the drive motor, the screw can be driven to rotate, which in turn drives the sealing device and the self-locking device to rotate and tighten. After installation, it can be manually removed for easy tightening of the other end. This makes the operation simple, saves effort and time when driving the sealing device to tighten the seal, and increases the efficiency of the test. Attached Figure Description

[0075] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0076] Figure 2 This is a schematic diagram of the overall disassembled structure provided by the present invention;

[0077] Figure 3 This is a schematic diagram of the chromatographic column splitting structure provided by the present invention;

[0078] Figure 4 This is a schematic diagram of the connection structure between the first limiting component and the second limiting component provided by the present invention;

[0079] Figure 5 This is a schematic diagram of the disassembled structure of the first limiting component provided by the present invention;

[0080] Figure 6 This is a schematic diagram of the second limiting component structure provided by the present invention;

[0081] Figure 7 A schematic diagram of the internal cavity assembly structure provided by the present invention;

[0082] Figure 8 This is a schematic diagram of the disassembled structure of the self-locking device provided by the present invention;

[0083] Figure 9 This is a schematic diagram of the tapping assembly structure provided by the present invention;

[0084] Figure 10 This is a schematic diagram of the disassembled structure of the sealing device provided by the present invention;

[0085] Figure 11This is a schematic diagram of the disassembled structure of the sealing assembly provided by the present invention;

[0086] Figure 12 This is a schematic diagram of the connection structure of the clamping device provided by the present invention;

[0087] Figure 13 This is a schematic diagram of the clamping device structure provided by the present invention;

[0088] Figure 14 This is a schematic diagram of the external driving device provided by the present invention.

[0089] In the diagram: chromatographic column 1, outer cavity assembly 11, outer cavity 111, outer cavity thread 112, first limiting assembly 12, first limiting plate 121, pressing plate 122, spring 123, second limiting assembly 13, second limiting plate 131, limiting groove 132, inner cavity assembly 14, inner cavity 141, embedded groove 142, limiting block 143, self-locking device 2, self-locking assembly 21, I-beam sleeve 211, inner groove 212, self-locking thread 213, tapping assembly 22, tapping nut 221, tapping thread 222, clamping groove 223, sealing device. 3. Sealing assembly 31, sealing cap 311, internal thread 312, compression plug 313, plug 314, movable assembly 32, screw 321, movable block 322, protruding post 323, bracket assembly 33, limiting plate 331, limiting bracket 332, positioning groove 333, drive groove 334, clamping device 4, clamping block 41, guide rod 42, first guide shaft seat 43, bending rod 44, second guide shaft seat 45, drive connecting rod 46, external drive device 5, drive motor 51, mounting plate 52, positioning post 53, drive rod 54. Implementation

[0090] To make the objectives, technical solutions, and advantages of the present invention clearer, the embodiments of the present invention will be described in further detail below with reference to the accompanying drawings.

[0091] This invention provides an analytical liquid chromatography column with advantages such as easy disassembly and replacement of the inner cavity, reducing maintenance and replacement time, facilitating alternating use of the inner cavity, and simplifying tightening operations by saving time and effort. It also makes tightening the sealing device easier, thereby increasing the efficiency of detection experiments. Please refer to [link to relevant documentation]. Figure 1-14 It includes a chromatographic column 1, a self-locking device 2, a sealing device 3, a clamping device 4, and an external driving device 5;

[0092] The chromatographic column 1 is capable of distributing and placing the various components of a mixture internally. Through the design and cooperation of the first limiting component 12 and the second limiting plate 131, the inner cavity 141 is securely placed inside the outer cavity 111, preventing the inner cavity 141 from shaking while facilitating its disassembly and replacement. This reduces maintenance and replacement time, allows for convenient alternation of the inner cavity 141, and increases the efficiency of the detection experiment. The chromatographic column 1 includes: an outer cavity component 11, an outer cavity 111, an outer cavity thread 112, a first limiting component 12, a first limiting plate 121, a pressing plate 122, a spring 123, a second limiting component 13, a second limiting plate 131, a limiting groove 132, an inner cavity component 14, and an inner cavity 141. The outer cavity assembly 111 includes an inner groove 142 and a limiting block 143, and an outer cavity assembly 11, which houses the inner cavity assembly 14. An outer cavity thread 112 on the outer wall of the outer cavity 111 allows the sealing cap 311 to be threaded onto both sides of the outer cavity 111. This allows the compression plug 313 and the plug 314 of the sealing cap 311 to continuously compress the inner cavity 141, thereby increasing sealing performance and preventing leakage of the components of the internal mixture. The outer cavity 111 houses the inner cavity assembly 14. The outer cavity thread 112 is located at both ends of the outer wall of the outer cavity 111 and allows for threaded connection to the sealing device 3. The first limiting assembly 12 is located around the inner wall of the outer cavity assembly 11 and allows for compression around the inner cavity assembly 14. The pressure, through the cooperation of the first limiting component 12 and the second limiting plate 131, allows the inner cavity 141 to be securely placed inside the outer cavity 111, thereby preventing the inner cavity 141 from shaking and facilitating its disassembly and replacement. This reduces maintenance and replacement time, facilitates the alternating use of the inner cavity 141, and increases the efficiency of testing experiments. The first limiting plate 121 is disposed around the inner wall of the outer cavity component 111. The pressing plate 122 is slidably connected inside the first limiting plate 121, and its outer side presses against the outer wall of the inner cavity component 141. The spring 123 has one end connected to the inner side of the pressing plate 122 and the other end connected to the inside of the first limiting plate 121, and can push the pressing plate 122 out. The second limiting plate 123... Positioning component 13 is disposed around the inner wall of outer cavity component 11 and is staggered with first positioning component 12, and can limit the placement of inner cavity component 14. Second positioning plate 131 is disposed around the inner wall of outer cavity component 11 and is staggered with first positioning plate 121. Positioning groove 132 is disposed inside second positioning plate 131 and is internally slidably connected to the outer wall of inner cavity component 14. Inner cavity component 14 has two internal ends that can distribute and place the various components of the mixture. Through the embedded groove 142 and positioning block 143 designed on the outer wall of inner cavity component 14, inner cavity 141 can be easily inserted into outer cavity 111, and inner cavity 141 can be stably installed inside outer cavity 111, preventing inner cavity 141 from shaking.The inner cavity 141 can be easily disassembled and replaced. The inner cavity 141 is detachably installed inside the outer cavity 111. An inner groove 142 is located around the outer wall of the inner cavity 141 and is internally slidably connected to a pressing plate 122, allowing it to be pressed by the pressing plate 122. A limiting block 143 is located around the outer wall of the inner cavity 141, interleaved with the inner groove 142, and slidably connected inside a second limiting plate 131.

[0093] The self-locking device 2 is located at both ends of the outer wall of the chromatographic column 1 and can cooperate with the sealing device 3 to seal both ends of the chromatographic column 1. Through the cooperation of the self-locking device 2, the sealing device 3, and the clamping device 4, the clamping device 4 can clamp the self-locking device 2, compressing and sealing the outer cavity 111 and the inner cavity 141 of the sealing device 3. At the same time, after clamping, the continuous rotation of the clamping device 4 causes the sealing device 3 and the tapping nut 221 to rotate simultaneously, tightening the threads of the sealing device 3. This increases the compression force of the outer cavity 111 and the inner cavity 141, while also increasing the sealing performance of the outer cavity 111 and the inner cavity 141, ensuring that the inner cavity 141 maintains a high gas pressure for convenient detection operations. The self-locking device 2 includes: a self-locking component 21, an I-beam sleeve 211, an inner groove 212, a self-locking thread 213, a tapping component 22, and a tapping nut 221. The device includes a tapping thread 222 and a clamping groove 223, a self-locking assembly 21, which is located at both ends of the outer wall of the outer cavity 111; an I-beam sleeve 211, which is located at both ends of the outer wall of the outer cavity 111; an inner groove 212, which is located in the middle of the outer wall of the I-beam sleeve 211; a self-locking thread 213, which is located around the outer wall of the inner groove 212 and is threadedly connected to the tapping assembly 22; the tapping assembly 22, which is threadedly connected to the outer wall of the self-locking assembly 21 and is clamped by the clamping device 4, so that the sealing device 3 is tightly connected to both ends of the outer cavity 111; a tapping nut 221, which has a tapping thread 222 inside, and the tapping nut 221 is threadedly connected to the self-locking thread 213 through the tapping thread 222, so that the tapping nut 221 can move between the inner groove 212 of the I-beam sleeve 211; and a clamping groove 223, which is located around the outer wall of the tapping nut 221 and can be clamped and fixed by the clamping device 4.

[0094] The sealing device 3 is threadedly connected to both ends of the outer wall of the chromatographic column 1, and can seal both ends of the chromatographic column 1. The sealing device 3 can compress and seal the outer cavity 111 and the inner cavity 141 on one side, and on the other side, by rotating the screw 321, it can drive the clamping device 4 to perform a clamping operation. After clamping, it drives the clamping device 4, the sealing device 3, and the tapping nut 221 to rotate, thereby tightening the threads and further increasing the sealing performance. The sealing device 3 includes: a sealing component 31, a sealing cap 311, an internal thread 312, a compression plug 313, a plug 314, a movable component 32, a screw 321, and a movable block 32. 2. A protruding post 323, a bracket assembly 33, a limiting disc 331, a limiting bracket 332, a positioning groove 333, a driving groove 334, a sealing assembly 31 (threadedly connected to the external cavity thread 112, sealing both sides of the external cavity 111 and the inner cavity 141), a sealing cap 311 (with an internal thread 312 on its inner wall, threadedly connected to the external cavity thread 112, sealing both sides of the external cavity 111 and the inner cavity 141), and a compression plug 313 (located at the center of the sealing cap 311, I-shaped, and inserted into both sides of the external cavity 111). The inner cavity 141 is compressed and sealed at both sides. A plug 314, located at the outer port of the compression plug 313 and inserted into the inner cavity 141, seals both sides of the inner cavity 141. A movable component 32, rotatably connected to the center of the outer wall of the sealing component 31, drives the clamping device 4. A screw 321, rotatably connected to the center of the sealing cap 311 and the support assembly 33. A movable block 322, threadedly connected to the outer wall of the screw 321. Protrusions 323, located around the outer wall of the movable block 322. It can be connected to the clamping device 4 and can drive the clamping device 4 to perform clamping operations. The bracket assembly 33 is connected to the outside of the sealing assembly 31, and the central rotating connection between the bracket assembly 33 and the sealing assembly 31 is the movable assembly 32. The limiting plate 331 has a limiting bracket 332 on its inner wall, and the other end of the limiting bracket 332 is connected to the outer wall of the sealing cap 311. The positioning groove 333 is set on the outer wall of the limiting plate 331 and can position the connection of the external driving device 5. The driving groove 334 is set in the center of the limiting plate 331 and the outer port of the screw 321 is inserted inside.

[0095] The clamping device 4 is arranged around the sealing device 3 and clamps the self-locking device 2. It also drives the self-locking device 2 and the sealing device 3 to rotate, thus securing and sealing both ends of the chromatographic column 1. The clamping device 4 is driven by the screw 321, which moves the movable block 322 and the protrusion 323, causing the clamping block 41 to be clamped inside the clamping groove 223. This causes the sealing cap 311 to press against the outer cavity 111 and the inner cavity 141. When the movable block 322 moves to its lowest position, the movable block 322... When the sealing cap 311 contacts, it generates significant friction, thereby tightening the screw 321 and preventing it from rotating. When rotational force is applied to the screw 321 again, it will cause the sealing cap 311 and the clamping block 41 to rotate simultaneously. This also causes the tapping nut 221 to tighten onto the self-locking thread 213 of the I-beam sleeve 211, achieving secondary tightening and increasing the sealing and airtightness of the inner cavity 141. The clamping device 4 includes: a clamping block 41, a guide rod 42, a first guide shaft seat 43, a folding rod 44, and a second... The guide shaft seat 45 and drive connecting rod 46, clamping block 41, which is clamped around the inside of the clamping groove 223, guide rod 42, one end of which is rotatably connected to the two ends of the inner side of the outer wall of the clamping block 41, and the other end of which is rotatably connected to the two ends of the outer wall of the first guide shaft seat 43, guide rod 42 to guide the rotation of the clamping block 41, facilitating the clamping operation of the clamping block 41, the first guide shaft seat 43, which is set around the outer wall of the sealing cap 311, and folding rod 44, one end of which is rotatably connected to the two ends of the outer side of the outer wall of the clamping block 41, middle The first guide shaft seat 43 is rotatably connected to both ends of the outer wall of the second guide shaft seat 45 and rotatably connected to both ends of the outer wall of the drive connecting rod 46. By rotating the folding rod 44, the clamping block 41 at the front end of the folding rod 44 can clamp it. The second guide shaft seat 45 is set around the outer wall of the sealing cap 311 and placed outside the first guide shaft seat 43. The drive connecting rod 46 is rotatably connected to the folding rod 44 at one end and rotatably connected to the outer wall of the protrusion 323 at the other end, and can be driven by the protrusion 323, thereby driving the clamping block 41 to perform the clamping operation.

[0096] An external drive device 5 is detachably mounted on the outer wall of the sealing device 3 and can drive the sealing device 3 to rotate, thereby driving the clamping device 4 to perform clamping and rotation operations. By holding the external drive device 5, the drive device 5 is placed on the surface of the limiting plate 331, while the positioning pin 53 is inserted into the positioning groove 333 and the drive rod 54 is inserted into the drive groove 334. By starting the drive motor 51, the screw 321 is driven to rotate, thereby driving the sealing device 3 and the self-locking device 2 to rotate and tighten. After installation, it can be manually removed for easy tightening of the other end, thus achieving simple operation and driving the sealing device 3. When performing sealing and tightening, it is more labor-saving and time-saving, and increases the detection efficiency of the experiment. The driving device 5 includes: a driving motor 51, a mounting plate 52, a positioning post 53 and a driving rod 54. The driving motor 51 is set on the outer wall of the mounting plate 52 and can be detachably installed on the outside of the sealing device 3. The positioning post 53 is set around the inner wall of the mounting plate 52 and can be inserted into the interior of the positioning groove 333, and can position the installation of the mounting plate 52. One end of the driving rod 54 is connected to the output end of the driving motor 51, and the other end passes through the center of the mounting plate 52 and the driving groove 334 and is inserted into the interior of the screw 321, and can drive the screw 321 to rotate.

[0097] In practical use, those skilled in the art insert the inner cavity 141 into the outer cavity 111, making the outer wall of the inner cavity 141 in close contact with the first limiting component 12 and the second limiting component 13. Then, install the sealing cap 311 at the tail of the inner cavity 141. Simultaneously, hold the drive motor 51 to insert the positioning pin 53 into the positioning groove 333, and insert the drive rod 54 into the screw 321. At this point, start the drive motor 51, causing it to drive the drive rod 54 and the screw 321 to rotate. This causes the movable block 322 and the protrusion 323 to move on the outer wall of the screw 321, thereby guiding the guide rod 42... The guide drives the bending rod 44 to rotate, causing the clamping block 41 to clamp the clamping groove 223 of the tapping nut 221. After the clamping is tightened, the drive motor 51 continues to rotate, thereby driving the sealing cap 311 and the tapping nut 221 to rotate, causing the extrusion plug 313 and the plug 314 to extrude into the inner cavity 141, sealing the tail of the inner cavity 141. Then, the components of the mixture are distributed into the interior of the inner cavity 141. Then, by installing the sealing cap 311, the sealing cap 311 is installed on the head of the outer cavity 111, thereby sealing both ends of the inner cavity 141, which facilitates experimental testing.

[0098] Although the present invention has been described above with reference to embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the invention. In particular, as long as there is no structural conflict, the features in the disclosed embodiments can be combined with each other in any manner. The lack of an exhaustive description of these combinations in this specification is merely for the sake of brevity and resource conservation. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. An analytical liquid chromatography column, characterized in that: include: The chromatographic column (1) is capable of distributing and placing the components of the mixture inside; the self-locking device (2) is located at both ends of the outer wall of the chromatographic column (1) and can cooperate with the sealing device (3) to seal both ends of the chromatographic column (1); the sealing device (3) is threadedly connected to both ends of the outer wall of the chromatographic column (1) and can seal both ends of the chromatographic column (1); the clamping device (4) is located around the sealing device (3) and clamps the self-locking device (2), while driving the self-locking device (2) and the sealing device (3) to rotate, thus securing and sealing both ends of the chromatographic column (1); the external drive device (5) is detachably installed on the outer wall of the sealing device (3) and can drive the sealing device (3) to rotate, thereby driving the clamping device (4) to perform clamping and rotation operations. The chromatographic column (1) includes: an outer cavity assembly (11). The outer cavity assembly (11) is capable of housing the inner cavity component (14); the first limiting component (12) is disposed around the inner wall of the outer cavity component (11) and can squeeze the inner cavity component (14); the second limiting component (13) is disposed around the inner wall of the outer cavity component (11) and is staggered with the first limiting component (12) and can limit the placement of the inner cavity component (14); the inner cavity component (14) has two ends inside which the components of the mixture can be distributed and placed, and the outer cavity component (11) includes: an outer cavity (111) which is capable of housing the inner cavity component (14); an outer cavity thread (112) which is disposed at both ends of the outer wall of the outer cavity (111) and can be threaded to the sealing device (3); the first limiting component (12) includes: a first limiting plate (121) which is disposed around the inner wall of the outer cavity component (11); and a pressing plate (122). The first limiting plate (121) is slidably connected inside the first limiting plate (121), and its outer side is pressed against the outer wall of the inner cavity assembly (14); the spring (123) is connected at one end to the inner side of the pressing plate (122) and at the other end to the inside of the first limiting plate (121), and can push the pressing plate (122) out; the second limiting assembly (13) includes: a second limiting plate (131), which is disposed around the inner wall of the outer cavity assembly (11) and is staggered with the first limiting plate (121); a limiting groove (132), which is disposed inside the second limiting plate (131) and is slidably connected to the outer wall of the inner cavity assembly (14); the inner cavity assembly (14) includes: an inner cavity (141), which is detachably installed inside the outer cavity (111); an inner groove (142), which is disposed around the outer wall of the inner cavity (141) and is slidably connected to the pressing plate (122). It can also be squeezed by the pressure plate (122);A limiting block (143) is disposed around the outer wall of the inner cavity (141) and is staggered with the inner groove (142), and is slidably connected to the inside of the second limiting plate (131).

2. The analytical liquid chromatography column according to claim 1, characterized in that, The self-locking device (2) includes: a self-locking assembly (21), which is disposed at both ends of the outer wall of the outer cavity (111); and a tapping assembly (22), which is threadedly connected to the outer wall of the self-locking assembly (21) and is clamped by the clamping device (4), so that the sealing device (3) is tightly connected to both ends of the outer cavity (111).

3. The analytical liquid chromatography column according to claim 2, characterized in that, The self-locking assembly (21) includes: an I-beam sleeve (211), which is disposed at both ends of the outer wall of the outer cavity (111); an inner groove (212), which is disposed at the middle position of the outer wall of the I-beam sleeve (211); and a self-locking thread (213), which is disposed around the outer wall of the inner groove (212), and the outer wall is threadedly connected to the tapping assembly (22); the tapping assembly (22) includes: a tapping nut (221), which is provided with a tapping thread (222) inside, and the tapping nut (221) is threadedly connected to the self-locking thread (213) through the tapping thread (222), so that the tapping nut (221) can move between the inner groove (212) of the I-beam sleeve (211); and a clamping groove (223), which is disposed around the outer wall of the tapping nut (221), and can be clamped and fixed by the clamping device (4).

4. The analytical liquid chromatography column according to claim 1, characterized in that, The sealing device (3) includes: a sealing component (31) which is threaded to the outer cavity thread (112) and can seal the two side ports of the outer cavity (111) and the inner cavity (141); a movable component (32) which is rotatably connected to the center of the outer wall of the sealing component (31) and can drive the clamping device (4); and a support component (33) which is connected to the outside of the sealing component (31) and the movable component (32) is rotatably connected to the center of the support component (33) and the sealing component (31).

5. The analytical liquid chromatography column according to claim 4, characterized in that, The sealing assembly (31) includes: a sealing cap (311) with an internal thread (312) on its inner wall, which is threaded to the external thread (112), and the sealing cap (311) can seal the two sides of the external cavity (111) and the internal cavity (141); a compression plug (313) which is located at the center of the sealing cap (311), is I-shaped, and is inserted into the two sides of the external cavity (111), and compresses the two sides of the internal cavity (141), while sealing the two sides of the internal cavity (141); a plug (314) which is located at the outer side of the compression plug (313), and is inserted into the two sides of the internal cavity (141), while sealing the two sides of the internal cavity (141); and a plug (314) which is located at the outer side of the compression plug (313), and is inserted into the two sides of the internal cavity (141), while sealing the two sides of the internal cavity (141); the movable assembly (32) includes: a screw (321) which is rotatably connected to the center of the sealing cap (311) and the support assembly (33); and a movable block (322). Its threaded connection is on the outer wall of the screw (321); the protrusion (323) is set around the outer wall of the movable block (322) and can be connected to the clamping device (4), and can drive the clamping device (4) to perform clamping operation; the bracket assembly (33) includes: a limiting plate (331) with a limiting bracket (332) on its inner wall and the other end of the limiting bracket (332) is connected to the outer wall of the sealing cap (311); a positioning groove (333) is set around the outer wall of the limiting plate (331) and can position the connection of the external driving device (5); a driving groove (334) is set in the center of the limiting plate (331) and the outer port of the screw (321) is inserted inside.

6. The analytical liquid chromatography column according to claim 1, characterized in that, The clamping device (4) includes: a clamping block (41) clamping around the inside of the clamping groove (223); a guide rod (42) with one end rotatably connected to both ends of the inner side of the outer wall of the clamping block (41) and the other end rotatably connected to both ends of the outer wall of the first guide shaft seat (43); the first guide shaft seat (43) being disposed around the outer wall of the sealing cap (311); a folding rod (44) with one end rotatably connected to both ends of the outer side of the outer wall of the clamping block (41), the middle end rotatably connected to both ends of the outer wall of the second guide shaft seat (45), and the end rotatably connected to both ends of the outer wall of the drive connecting rod (46); the second guide shaft seat (45) being disposed around the outer wall of the sealing cap (311) and placed outside the first guide shaft seat (43); and the drive connecting rod (46) with one end rotatably connected to the folding rod (44) and the other end rotatably connected to the outer wall of the protrusion (323), and capable of being driven by the protrusion (323). This causes the clamping block (41) to perform a clamping operation.

7. The analytical liquid chromatography column according to claim 1, characterized in that, The external drive device (5) includes: a drive motor (51), which is located on the outer wall of the mounting plate (52) and can be detachably installed on the outside of the sealing device (3); a positioning post (53), which is located around the inner wall of the mounting plate (52) and can be inserted into the interior of the positioning groove (333) and can position the mounting plate (52) for installation; and a drive rod (54), one end of which is connected to the output end of the drive motor (51), and the other end passes through the center of the mounting plate (52) and the drive groove (334) and is inserted into the interior of the screw (321) and can drive the screw (321) to rotate.

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