A skin care product for anti-wrinkle firming eye skin and a preparation method thereof

By combining a specific ratio of GABA, acetyl hexapeptide-8, dipeptide diaminobutyryl benzylamide diacetate, and plant extracts, a skin care product in emulsion form is prepared, which solves the shortcomings of existing skin care products in terms of permeability and stability, and achieves significant anti-aging and skin firming effects.

CN116850106BActive Publication Date: 2026-03-03陕西中药研究所
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-07-19
Publication Date
2026-03-03

AI Technical Summary

Technical Problem

Existing anti-aging skincare products have problems with skin penetration and stability, making it difficult to effectively improve aging skin around the eyes. Furthermore, they are difficult to use in combination and lack products with clear efficacy and high safety.

Method used

A combination of aminobutyric acid, acetyl hexapeptide-8, dipeptide diaminobutyryl benzylamide diacetate, and plant extracts (such as Sophora flavescens root, Glycyrrhiza uralensis root, and Scutellaria baicalensis root) in a specific ratio is used to prepare a skin care product in the form of an emulsion, which enhances skin permeability and stability and activates the transdermal co-delivery of the composition.

Benefits of technology

It significantly enhances the skin's anti-aging effects, increases skin permeability and stability, and provides clear anti-wrinkle and firming effects, especially in improving dynamic lines and wrinkles, and enhancing skin elasticity and firmness.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides a skin care product for anti-wrinkle skin tightening of eye skin and a preparation method thereof, and active components of the skin care product comprise, in terms of weight fractions, 0.1-2 parts of aminobutyric acid, 1-3 parts of dipeptide diaminobutyryl benzyl amide diacetate, 0.5-1 part of acetyl hexapeptide-8, and 9-35 parts of plant extracts; the plant extracts comprise, in terms of weight fractions, 1-5 parts of Sophora flavescens root extract, 3-10 parts of Glycyrrhiza inflata root extract, and 5-20 parts of Scutellaria baicalensis root extract. The application constructs an effective proportion of five compositions of dipeptide diaminobutyryl benzyl amide diacetate, acetyl hexapeptide-8, Sophora flavescens root extract, Glycyrrhiza inflata root extract and Scutellaria baicalensis root extract, so as to activate transdermal co-delivery of the compositions, increase skin permeability of the product, effectively enhance skin anti-aging effects of the active peptides, and improve stability of the active peptides.
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Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a skin care product for anti-wrinkle and firming the skin around the eyes and its preparation method. Background Technology

[0002] With changing lifestyles and rising aesthetic standards, consumers are becoming increasingly discerning in their selection of skincare products, making eye care products a necessity. Developing highly effective anti-aging products has become a hot topic and a major area of ​​research and development in today's market.

[0003] The skin around the eyes is the thinnest part of the face. As we age, the body loses collagen, and the skin tissue begins to collapse and age. Around the age of 30, some of the first signs of aging around the eyes begin to appear, such as dark circles, eye bags, and crow's feet. Furthermore, modern people's long-term sleep deprivation, exposure to electronic screens, improper use of the eyes, and external environmental factors can also exacerbate the memory damage to the skin around the eyes.

[0004] Scientific research shows that the mechanisms of skin aging include endogenous and exogenous mechanisms. Endogenous factors are an irreversible and slow physiological process. Endogenous skin aging only becomes apparent after a certain age, characterized by dry, rough skin, reduced elasticity, and wrinkles. With age, the number of dermal mast cells and fibroblasts decreases, collagen secretion declines, and the dermal-epidermal junction flattens. Combined with the effects of aging in other internal organs, these factors lead to endogenous skin aging. Intervening in endogenous natural aging is extremely difficult for skin anti-aging; therefore, researchers focus more on the prevention and treatment of exogenous factors that affect the skin's physiological structure or appearance. In the 1990s, products incorporating biomolecules such as DNA and proteins were popular. However, research shows that these macromolecular active ingredients are difficult to absorb through the epidermis. Later, researchers discovered that active peptides composed of a few amino acids, as protein mimics, are more easily absorbed through the skin barrier while possessing advantages such as good safety and high bioactivity. Anti-aging active peptides can control or regulate the skin aging process, protect damaged skin, delay skin aging, and improve skin problems at different levels, showing excellent effects in anti-aging applications. However, the effects of a single substance often have certain limitations and cannot comprehensively improve skin aging phenomena. Therefore, exploring compound formulations has gradually become a major direction for companies developing skincare products. Peptides and plant extracts (containing antioxidant active substances) are common research subjects in anti-skin aging and are also common combinations for improving skin damage.

[0005] Currently, while there are many active ingredients on the market with anti-aging functions, they often suffer from poor skin penetration, poor stability, and difficulties in combined use. There is a lack of anti-aging products with clearly defined efficacy, high safety, and strong stability that protect the delicate skin around the eyes. Summary of the Invention

[0006] The purpose of this invention is to provide a skin care product for anti-wrinkle and firming the skin around the eyes and a method for preparing the same, thereby solving the problems faced by the skin care product market mentioned in the background art.

[0007] This invention is achieved through the following technical solution:

[0008] A skincare product for anti-wrinkle and firming the skin around the eyes, comprising, by weight, the active ingredients of: 0.1-2 parts of aminobutyric acid, 1-3 parts of dipeptide diaminobutyryl benzylamide diacetate, 0.5-1 parts of acetyl hexapeptide-8, and 9-35 parts of plant extracts.

[0009] The plant extracts, by weight, include: 1-5 parts of Sophora flavescens root extract, 3-10 parts of Glycyrrhiza uralensis root extract, and 5-20 parts of Scutellaria baicalensis root extract.

[0010] Preferably, the product also includes excipients, which, by weight, include: 10-15 parts butylene glycol, 5-10 parts glycerin, 2-5 parts nicotinamide, 1-3 parts sodium hyaluronate, 0.5-2 parts sodium polyglutamate, and 0.01-0.03 parts rose oil.

[0011] Preferably, by weight, its active components include: 1 part of aminobutyric acid, 2 parts of dipeptide diaminobutyryl benzylamide diacetate, 0.7 parts of acetyl hexapeptide-8, and 20 parts of plant extract;

[0012] The plant extracts, by weight, include: 3 parts Sophora flavescens root extract, 5 parts Glycyrrhiza uralensis root extract, and 12 parts Scutellaria baicalensis root extract.

[0013] Furthermore, it also includes excipients, which, by weight, include: 13 parts butylene glycol, 7 parts glycerin, 3 parts nicotinamide, 2 parts sodium hyaluronate, 1 part sodium polyglutamate, and 0.02 parts rose oil.

[0014] Preferably, by weight, its active components include: 1.5 parts of aminobutyric acid, 3 parts of dipeptide diaminobutyryl benzylamide diacetate, 1 part of acetyl hexapeptide-8, and 35 parts of plant extract;

[0015] The plant extracts, by weight, include: 5 parts Sophora flavescens root extract, 10 parts Glycyrrhiza uralensis root extract, and 20 parts Scutellaria baicalensis root extract.

[0016] Furthermore, it also includes excipients, which, by weight, include: 15 parts butylene glycol, 10 parts glycerin, 5 parts nicotinamide, 3 parts sodium hyaluronate, 2 parts sodium polyglutamate, and 0.03 parts rose oil.

[0017] Preferably, the active ingredient is prepared into an emulsion.

[0018] The method for preparing the skincare product for anti-wrinkle and firming the skin around the eyes includes:

[0019] Sodium hyaluronate was dissolved in water to obtain phase A;

[0020] Sodium polyglutamate and aminobutyric acid were pre-dissolved in butanediol, glycerol and water to obtain phase B;

[0021] Dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8, and nicotinamide were added to phase B and stirred to dissolve, thus obtaining phase C.

[0022] Sieve phase C, add it to phase A, mix well, and obtain phase D;

[0023] Add rose oil to phase D, mix well, and age to obtain a skin care product for anti-wrinkle and firming the skin around the eyes.

[0024] Preferably, the aging temperature is no higher than 38℃.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] This invention relates to a skincare product for anti-wrinkle and firming the skin around the eyes. It combines the use of highly active bioactive peptides, acetyl hexapeptide-8 and dipeptide-diaminobutyryl benzylamide diacetate, with a purity exceeding 99%. It also incorporates natural herbal extracts that significantly scaveng and inhibit superoxide anions and hydroxyl radicals: Sophora flavescens root extract, Glycyrrhiza uralensis root extract, and Scutellaria baicalensis root extract. Acetyl hexapeptide-8 is a botulinum toxin-like ingredient, possessing all the functions of botulinum toxin without any toxicity; it is a non-toxic substance. Acetyl hexapeptide-8 has similar effects in inhibiting neurotransmitters, blocking the transmission between neuromuscular pathways, thereby preventing the formation of fine lines and wrinkles. Dipeptide-diaminobutyryl benzylamide diacetate, also known as snake venom tripeptide, is also a botulinum toxin-like ingredient; it can slow muscle contraction, providing timely and long-lasting wrinkle reduction. Acetyl hexapeptide-8 and snake venom tripeptide, when combined in a specific molar ratio, exhibit excellent anti-wrinkle and collagen regeneration capabilities, particularly targeting dynamic wrinkles; they also have a good smoothing and improving effect on existing wrinkles. Scutellaria baicalensis extract, by inhibiting elastase and promoting the production of ceramides, combined with its free radical scavenging effect, shows that the extract can increase skin metabolism, improve skin elasticity, and reduce wrinkles. Glycyrrhiza uralensis extract promotes the production of collagen-4 and inhibits NO production; it also promotes skin activity. Sophora flavescens extract has a strong ability to scavenge superoxide anions and hydroxyl radicals, protecting against cellular oxidative damage and exhibiting significant antioxidant effects. This invention constructs an effective formulation of five components: dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8, Sophora flavescens root extract, Glycyrrhiza uralensis root extract, and Scutellaria baicalensis root extract. This formulation activates transdermal co-delivery of the composition, increasing skin permeability and effectively enhancing the anti-aging effects of the active peptides. Simultaneously, it improves the stability of the active peptides. This invention solves the problems of poor skin permeability, poor stability, and difficulty in combined use of products on the market, providing a skincare product with clear efficacy, high safety, and strong stability for protecting the delicate skin around the eyes. Attached Figure Description

[0027] Figure 1 This represents the change in skin elasticity; significance level is indicated by "ns" for no significant difference, "*" for a significant difference, and 0.01 for a statistical significance level. <P<0.05;“**”,0.001<P<0.01;“***”,P<0.001。

[0028] Figure 2 This is a wrinkle area plot from week 0-4 of the Visia analysis; significance level is indicated by: “ns” for no significant difference, “*” for significant difference (0.01 ≤ P < 0.05), “**” for 0.001 ≤ P < 0.01, and “***” for P < 0.001.

[0029] Figure 3 A graph showing the permeation rate of acyl hexapeptide-8 versus time was plotted.

[0030] Figure 4 A graph showing the relationship between the permeation rate of baicalin and time was plotted. Detailed Implementation

[0031] To further understand the present invention, the present invention will be described below with reference to embodiments. These descriptions are only for further explaining the features and advantages of the present invention and are not intended to limit the claims of the present invention.

[0032] The skincare product for anti-wrinkle and firming the skin around the eyes described in this invention comprises, by weight parts:

[0033] Butylene glycol 10-15 parts, glycerin 5-10 parts, nicotinamide 2-5 parts, aminobutyric acid 0.1-2 parts, dipeptide diaminobutyryl benzylamide diacetate 1-3 parts, sodium hyaluronate 1-3 parts, sodium polyglutamate 0.5-2 parts, acetyl hexapeptide-8 0.5-1 part, rose (ROSA RUGOSA) flower oil 0.01-0.03 parts, plant extract 9-35 parts;

[0034] The plant extract, by weight, comprises:

[0035] 1-5 parts of Sophora flavescens root extract, 3-10 parts of Glycyrrhiza uralensis root extract, and 5-20 parts of Scutellaria baicalensis root extract.

[0036] The method for preparing the skincare product for anti-wrinkle and firming the skin around the eyes includes the following steps:

[0037] (1) Sodium hyaluronate was pre-dissolved in an appropriate amount of purified water to prepare phase A;

[0038] (2) Polyglutamate sodium and aminobutyric acid were pre-dissolved in butanediol, glycerol and an appropriate amount of purified water to prepare phase B;

[0039] (3) Add dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8 and nicotinamide to phase B and stir to dissolve, thus preparing phase C;

[0040] (4) Sieve phase C, add phase A and stir well to prepare phase D;

[0041] (5) Add rose oil to phase D and mix well;

[0042] (6) Weigh the contents and add water to the full volume;

[0043] (7) In the D-level clean area of ​​the aging room, age at a temperature not exceeding 38°C until the preparation is complete.

[0044] Example 1

[0045] Skincare products for anti-wrinkle and firming the skin around the eyes, by weight, include:

[0046] 10 parts butylene glycol, 5 parts glycerin, 2 parts nicotinamide, 0.5 parts aminobutyric acid, 1 part dipeptide diaminobutyryl benzylamide diacetate, 1 part sodium hyaluronate, 0.5 parts sodium polyglutamate, 0.5 parts acetyl hexapeptide-8, 0.01 parts rose oil, and 10 parts plant extracts.

[0047] The plant extract comprises, by weight, the following:

[0048] Two parts of Sophora flavescens root extract, three parts of Glycyrrhiza uralensis root extract, and five parts of Scutellaria baicalensis root extract.

[0049] Its preparation method includes the following steps:

[0050] (1) Sodium hyaluronate was pre-dissolved in an appropriate amount of purified water to prepare phase A;

[0051] (2) Polyglutamate sodium and aminobutyric acid were pre-dissolved in butanediol, glycerol and an appropriate amount of purified water to prepare phase B;

[0052] (3) Add dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8 and nicotinamide to phase B and stir to dissolve, thus preparing phase C;

[0053] (4) Pass phase C through a 120-mesh sieve, add phase A and stir well to prepare phase D;

[0054] (5) Add rose oil to phase D and mix well;

[0055] (6) Weigh the contents and add water to the full volume;

[0056] (7) In the D-level clean area of ​​the aging room, age for 48 hours at a temperature not exceeding 38°C to complete the preparation.

[0057] Example 2

[0058] Skincare products for anti-wrinkle and firming the skin around the eyes, by weight, include:

[0059] Butylene glycol 13 parts, glycerin 7 parts, nicotinamide 3 parts, aminobutyric acid 1 part, dipeptide diaminobutyryl benzylamide diacetate 2 parts, sodium hyaluronate 2 parts, sodium polyglutamate 1 part, acetyl hexapeptide-8 0.7 parts, rose oil 0.02 parts, plant extract 20 parts;

[0060] The plant extract comprises, by weight, the following:

[0061] Three parts of Sophora flavescens root extract, five parts of Glycyrrhiza uralensis root extract, and twelve parts of Scutellaria baicalensis root extract.

[0062] Its preparation method includes the following steps:

[0063] (1) Sodium hyaluronate was pre-dissolved in an appropriate amount of purified water to prepare phase A;

[0064] (2) Polyglutamate sodium and aminobutyric acid were pre-dissolved in butanediol, glycerol and an appropriate amount of purified water to prepare phase B;

[0065] (3) Add dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8 and nicotinamide to phase B and stir to dissolve, thus preparing phase C;

[0066] (4) Pass phase C through a 120-mesh sieve, add phase A and stir well to prepare phase D;

[0067] (5) Add rose oil to phase D and mix well;

[0068] (6) Weigh the contents and add water to the full volume;

[0069] (7) In the D-level clean area of ​​the aging room, age for 48 hours at a temperature not exceeding 38°C to complete the preparation.

[0070] Example 3

[0071] Skincare products for anti-wrinkle and firming the skin around the eyes, by weight, include:

[0072] Butylene glycol 15 parts, glycerin 10 parts, nicotinamide 5 parts, aminobutyric acid 1.5 parts, dipeptide diaminobutyryl benzylamide diacetate 3 parts, sodium hyaluronate 3 parts, sodium polyglutamate 2 parts, acetyl hexapeptide-8 1 part, rose oil 0.03 parts, plant extract 35 parts;

[0073] The plant extract comprises, by weight, the following:

[0074] Five parts of Sophora flavescens root extract, 10 parts of Glycyrrhiza uralensis root extract, and 20 parts of Scutellaria baicalensis root extract.

[0075] Its preparation method includes the following steps:

[0076] (1) Sodium hyaluronate was pre-dissolved in an appropriate amount of purified water to prepare phase A;

[0077] (2) Polyglutamate sodium and aminobutyric acid were pre-dissolved in butanediol, glycerol and an appropriate amount of purified water to prepare phase B;

[0078] (3) Add dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8 and nicotinamide to phase B and stir to dissolve, thus preparing phase C;

[0079] (4) Pass phase C through a 120-mesh sieve, add phase A and stir well to prepare phase D;

[0080] (5) Add rose oil to phase D and mix well;

[0081] (6) Weigh the contents and add water to the full volume;

[0082] (7) In the D-level clean area of ​​the aging room, age for 48 hours at a temperature not exceeding 38°C to complete the preparation.

[0083] Comparative Example 1

[0084] The plant extracts in the formula are 10 parts of Portulaca oleracea extract, 10 parts of Astragalus membranaceus root extract, and 10 parts of Paeonia suffruticosa root bark extract.

[0085] Comparative Example 2

[0086] The plant extracts in the formula are 10 parts of Tussilago farfara flower extract, 10 parts of Aloe barbadensis extract, and 10 parts of Angelica sinensis extract.

[0087] Consumer reviews of anti-wrinkle and firming cosmetics:

[0088] Seventy-five subjects of different genders aged 22-59 years were randomly selected and divided into five groups of 15 people each. They used the skin care product formula samples of Examples 1-3 and Comparative Examples 1-2 respectively. The use period was 28 days. At the end of the test period, a related questionnaire survey was conducted.

[0089] Table 1 Sensory ratings of subjects after 28 days of using the test product

[0090]

[0091] *Evaluation metrics: 1 point indicates strong disagreement, 2 points indicates some disagreement, 4 points indicates some agreement, and 5 points indicates strong agreement; the percentage of "4 points some agreement" and "5 points strong agreement" after 1 week and 4 weeks of product use.

[0092] Based on the results of 75 subjects using this test product for 28 consecutive days, the following conclusions can be drawn from Table 1:

[0093] After 28 days of use, the overall acceptance rate of Example 3 was the highest, at 100%. Among the participants, 86.66% felt that the elasticity of the skin around the eyes had improved, 80% felt that the skin around the eyes had become firmer, and 86.66% felt that the wrinkles around the eyes had become less noticeable. The overall acceptance rate of Example 3 was higher than that of the comparative product, indicating that the anti-wrinkle and firming effects were most significant when the plant extracts were Sophora flavescens root extract, Glycyrrhiza uralensis root extract, and Scutellaria baicalensis root extract.

[0094] Human efficacy evaluation experiments for cosmetics:

[0095] Based on the consumer evaluation results, the product formula of Example 3 was selected for human efficacy evaluation experiments to further verify the safety and efficacy of the product.

[0096] Evaluation of the anti-wrinkle and firming effects of cosmetics on the human body:

[0097] Thirty-two subjects of different genders and ages between 22 and 59 years were randomly selected according to the subject criteria. They used the skin care product formula sample of Example 3 for 28 days, and the relevant instrument tests were completed on days 0, 7, 14 and 28.

[0098] The specific testing process is as follows:

[0099] D0:

[0100] 1) Subject information registration, testers screen faces, and informed consent is signed after inclusion and exclusion criteria are met;

[0101] 2) Subjects cleaned their faces with facial cleansing products and dried their skin with a dry towel. They then sat quietly for 30 minutes in an efficacy evaluation room with a temperature of 20±1℃ and a humidity of 50±10%RH.

[0102] 3) Test the elasticity and firmness of the skin on both cheeks of the subject and take a full-face photo with Visia-CR;

[0103] 4) Test personnel guide subjects on how to use the product according to the product usage requirements;

[0104] 5) The subjects received the product and usage diary, and left the efficacy evaluation room.

[0105] D7:

[0106] 1) Subjects were followed up. They cleaned their faces with facial cleansing products and dried their skin with a dry towel. They sat quietly for 30 minutes in an efficacy evaluation room with a temperature of 20±1℃ and a humidity of 50±10%RH.

[0107] 2) Test the elasticity and firmness of the skin on both cheeks of the subject and take a full-face photo with Visia-CR;

[0108] 3) Subjects sign out.

[0109] D14:

[0110] 1) Subjects were followed up. They cleaned their faces with facial cleansing products and dried their skin with a dry towel. They sat quietly for 30 minutes in an efficacy evaluation room with a temperature of 20±1℃ and a humidity of 50±10%RH.

[0111] 2) Test the elasticity and firmness of the skin on both cheeks of the subject and take a full-face photo with Visia-CR;

[0112] 3) Subjects sign out.

[0113] D28:

[0114] 1) Subjects were followed up. They cleaned their faces with facial cleansing products and dried their skin with a dry towel. They sat quietly for 30 minutes in an efficacy evaluation room with a temperature of 20±1℃ and a humidity of 50±10%RH.

[0115] 2) Test the elasticity and firmness of the skin on both cheeks of the subject and take a full-face photo with Visia-CR;

[0116] 3) Subjects sign out.

[0117] The test items include the following:

[0118] Table 2 Test Items

[0119]

[0120]

[0121] Feedback on adverse reactions during use

[0122] All 32 participants used the product as required within the specified time, and no adverse reactions occurred.

[0123] Difference analysis

[0124] Statistical analysis was performed to examine the differences in test results before and after sample use at different time points, and a normality test was conducted. If the data conformed to a normal distribution, a t-test was used; otherwise, a rank-sum test was employed. All statistical analyses were two-tailed tests, with a significance level of α = 0.05. If there was a significant difference in test results before and after sample use (P < 0.05), the sample was considered to have corresponding efficacy in the test area.

[0125] Test Results

[0126] 1. Skin elasticity test results

[0127] Skin elasticity test results, such as Figure 1 As shown.

[0128] R² value: After 1 week of product use, the skin elasticity R² value improved, but the improvement was not statistically significant compared with the initial value, with an improvement rate of 3.322%; after 2 weeks of product use, the R² value showed a statistically significant improvement compared with the initial value, with an improvement rate of 5.314%; after 4 weeks of product use, the R² value showed a highly statistically significant improvement compared with the initial value, with an improvement rate of 21.304%.

[0129] R5 value: After 1 week of product use, the skin's net elasticity R5 value improved, but the improvement was not statistically significant compared to the initial value, with an improvement rate of 2.101%; after 2 weeks of product use, the R5 value showed a statistically significant improvement compared to the initial value, with an improvement rate of 5.231%; after 4 weeks of product use, the R5 value showed a highly statistically significant improvement compared to the initial value, with an improvement rate of 11.323%.

[0130] R7 value: After 1 week of product use, the skin elasticity R7 value improved, but the improvement was not statistically significant compared with the initial value, with an improvement rate of 1.954%; after 2 weeks of product use, the R7 value showed a statistically significant improvement compared with the initial value, with an improvement rate of 7.545%; after 4 weeks of product use, the R7 value showed a highly statistically significant improvement compared with the initial value, with an improvement rate of 21.365%.

[0131] 2. Wrinkle area test results

[0132] like Figure 2 As shown, after 7 days of product use, the wrinkle area of ​​the subjects was significantly reduced, with a reduction rate of 12.18%; after 14 days of product use, the wrinkle area was significantly reduced, with a reduction rate of 17.52%; and after 28 days of product use, the wrinkle area was highly significantly reduced, with a reduction rate of 22.53%.

[0133] Determination of transdermal absorption rate of active ingredient in the composition:

[0134] Using a TK-12B transdermal diffusion assay apparatus, rat skin was fixed between the upper and lower chambers of the diffusion chamber with the stratum corneum facing upwards. 1.0 g of sample was accurately weighed and placed in the supply chamber, and stirred continuously at a constant temperature [(37±1)℃] and constant speed (300 r / min). 2 ml of the receiving solution was collected at 1, 2, 3, 4, 5, and 6 hours after application for testing.

[0135] Results of in vitro transdermal absorption:

[0136] In in vitro transdermal absorption experiments, the cumulative permeation of acetyl hexapeptide-8 and baicalin gradually increased with time. A graph showing the permeation of acetyl hexapeptide-8 and baicalin against time is shown below. Figure 3 , Figure 4 In the figure, ratio 1 is Example 1, ratio 2 is Example 2, and ratio 3 is Example 3.

[0137] Table 3. Proportions of different compositions

[0138]

[0139]

[0140] Through experimental transdermal absorption rate determination, the optimal ratio of dipeptide diaminobutyryl benzylamide diacetate, acetyl hexapeptide-8, Sophora flavescens root extract, Glycyrrhiza inflata root extract, and Scutellaria baicalensis root extract was determined to be the composition ratio of Example 3.

[0141] Product stability testing:

[0142] An electric centrifuge was used to centrifuge the sample at 2000–5000 r / min for 30 min. After centrifugation, the oil-water separation phenomenon was observed and the centrifugal stability of the sample was measured. The thermal stability of the sample was determined using a high and low temperature test chamber. The procedure was as follows: first, the sample was kept at 40℃ for 24 h, and then at 15℃ for 24 h. The changes in the oil-water separation phenomenon of the sample were observed.

[0143] Table 4. Centrifugal stability of samples

[0144]

[0145] Table 5. Thermal stability of samples

[0146]

[0147] In summary, this invention provides a skincare product for anti-wrinkle and firming the skin around the eyes, and its preparation method. The formula not only contains natural herbal extracts such as Sophora flavescens root extract, Glycyrrhiza uralensis root extract, and Scutellaria baicalensis root extract, which have significant scavenging and inhibitory effects on superoxide anions and hydroxyl radicals, but also dipeptide diaminobutyryl benzylamide diacetate and acetyl hexapeptide-8. These two are already excellent choices for improving skin firmness. Combined with the antioxidant effects of the three natural herbal ingredients, it can more quickly eliminate free radicals and deeply nourish and condition the skin. This solves the problems of poor skin penetration, poor stability, and difficulty in combined use of products on the market. It provides a skincare product with clear efficacy, high safety, and strong stability to protect the delicate skin around the eyes.

Claims

1. A skin care product for anti-wrinkle firming the eye skin, characterized by, The active component consists of the following components by weight: aminobutyric acid 1.5 parts, dipeptide diaminobutyryl benzyl amide diacetate 3 parts, acetyl hexapeptide-8 1 part, and plant extract 35 parts. The plant extract consists of the following components by weight: Sophora flavescens root extract 5 parts, Glycyrrhiza inflata root extract 10 parts, and Scutellaria baicalensis root extract 20 parts; and the auxiliary material consists of the following components by weight: butanediol 15 parts, glycerol 10 parts, nicotinamide 5 parts, sodium hyaluronate 3 parts, sodium polyglutamate 2 parts, and rose oil 0.03 parts.

2. The method for preparing a skin care product for anti-wrinkle firming the eye skin of claim 1, characterized in that, The active component is prepared into an emulsion.

3. The method for preparing a skin care product for anti-wrinkle firming the eye skin of claim 1, characterized in that, The method comprises the following steps: Sodium hyaluronate is dissolved in water to obtain phase A; Sodium polyglutamate and aminobutyric acid are pre-dissolved in butanediol, glycerol and water to obtain phase B; Dipeptide diaminobutyryl benzyl amide diacetate, acetyl hexapeptide-8 and nicotinamide are added to phase B and stirred to dissolve to obtain phase C; Phase C is sieved and added to phase A, and mixed uniformly to obtain phase D; Rose oil is added to phase D, mixed uniformly, and aged to obtain the skin care product for anti-wrinkle and firming eye skin.

4. The method for preparing a skin care product for anti-wrinkle firming eye skin according to claim 3, characterized in that, The aging temperature is not more than 38 DEG C.

Citation Information

Patent Citations

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