A composition for use in water-based cosmetics, an essence containing the composition, and a method for its preparation.

Abstract

This invention discloses a composition for water-based cosmetics, an essence containing the composition, and a preparation method thereof. The composition comprises, by weight, 0.5-20 parts polyethylene glycol, 0.5-10 parts polydimethylsiloxane, 0.05-0.5 parts a first thickener, and 0.05-1.0 parts a second thickener. The first thickener is obtained by compounding xanthan gum and hydroxyethyl cellulose at a mass ratio of 1:0.3-0.8. The second thickener is at least one of ammonium acryloyl dimethyl taurate / VP copolymer, sodium polyacryloyl dimethyl taurate, polyacrylate crosspolymer-6, and carbomer. The essence provided by this invention comprises the above composition and one or more of a skin conditioning agent, moisturizer, pH adjuster, preservative, and deionized water. The composition system of this invention is free of alcohol and emulsifiers, has stable physicochemical properties, and is simple and safe in composition. The essence acts on multiple targets, including hydration, promoting collagen synthesis, promoting cell proliferation, anti-glycation, and anti-oxidation, and has good firming and anti-wrinkle effects.

Description

Technical Field

[0001] This invention belongs to the field of skincare technology, specifically relating to a composition for water-based cosmetics, an essence containing the composition, and a preparation method thereof. Background Technology

[0002] Currently, serums and facial masks on the market are categorized into non-emulsified and emulsion forms. Non-emulsified serums and facial masks are thickened with polymer gels, and the addition of active ingredients makes them sticky and not refreshing after application. Many products achieve a refreshing feel by adding alcohol (e.g., patent documents CN107510626A, CN116265006A); however, alcohol can cause significant irritation and allergic reactions to the skin. Emulsion-type serums and facial masks, due to the addition of oil-phase components, use a large amount of surfactants (such as emulsifiers), which can irritate the skin.

[0003] Therefore, developing a composition that is free of alcohol and emulsifiers, refreshing and easily absorbed, with low skin irritation and stable physicochemical properties, and can be used to prepare water-based cosmetics such as serums, facial masks, and toners, has significant practical application value.

[0004] In view of this, the present invention is proposed. Summary of the Invention

[0005] To address the aforementioned technical problems, the present invention aims to provide a composition for water-based cosmetics, an essence containing the composition, and a preparation method thereof, which solves the problem of stickiness and slow absorption of products such as essences by not adding alcohol and emulsifiers.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] In a first aspect, the present invention provides a composition for use in aqueous cosmetics, comprising, by weight, the following components: 0.5 to 20 parts polyethylene glycol, 0.5 to 10 parts polydimethylsiloxane, 0.05 to 0.5 parts a first thickener, and 0.05 to 1.0 parts a second thickener;

[0008] The first thickener is a compound of xanthan gum and hydroxyethyl cellulose;

[0009] The second thickener is at least one of ammonium acryloyldimethyl taurate / VP copolymer, sodium polyacryloyldimethyl taurate, polyacrylate crosspolymer-6, and carbomer.

[0010] The above composition does not contain alcohol or emulsifiers, resulting in a better skin feel and higher safety.

[0011] As a more preferred technical solution of the present invention, the second thickener is ammonium acryloyldimethyl taurate / VP copolymer.

[0012] As a more preferred technical solution of the present invention, the polyethylene glycol is selected from at least one of polyethylene glycol 200, polyethylene glycol 300, and polyethylene glycol 400.

[0013] As a more preferred technical solution of the present invention, the mass ratio of xanthan gum to hydroxyethyl cellulose is 1:0.3 to 0.8.

[0014] In a second aspect, the present invention provides a method for preparing the above-mentioned composition, comprising the following steps:

[0015] (1) Disperse the first thickener and the second thickener evenly with polyethylene glycol solution, add deionized water, stir homogenously and heat to 70-75°C to completely dissolve the material;

[0016] (2) Cool down to 40-45℃, add polydimethylsiloxane and stir homogenously until evenly mixed to obtain the final product.

[0017] As a more preferred technical solution of the present invention, in step (1) above, the homogenization rate of the homogenizing stirring is 4000-4500 r / min, the stirring speed is 20-40 r / min, and the homogenization time is 5-10 min.

[0018] As a more preferred technical solution of the present invention, in step (2) above, the homogenization rate of the homogenizing stirring is 5000-6000 r / min, the stirring speed is 30-50 r / min, and the stirring and homogenization time is 10-15 min.

[0019] It is understood that, and it should be particularly emphasized, the compositions of this invention can be prepared alone according to the above method and then used in the preparation of other products; the preparation method can also be adapted to the characteristics of other products and is not limited to the usage shown in the above preparation method.

[0020] Thirdly, the present invention also provides the use of the above composition in the preparation of lotions, serums or facial mask liquids.

[0021] Fourthly, the present invention also provides a serum containing the above-described composition that has firming and anti-wrinkle effects.

[0022] As a more preferred technical solution of the present invention, the above-mentioned essence also includes one or more of the following: skin conditioning agent, moisturizer, pH adjuster, preservative, and deionized water.

[0023] Furthermore, by weight, the specific amounts of each substance in the above-mentioned serum are as follows: 0.05-30 parts skin conditioning agent, 0.5-10 parts moisturizer, 0.01-1 part pH adjuster, 0.1-2 parts preservative, and 40-90 parts deionized water.

[0024] It is understood that the moisturizer may be selected from cosmetic moisturizers known to those skilled in the art, such as one or more combinations of glycerin, butylene glycol, 1,3-propanediol, and pentanediol. The pH adjuster may be selected from cosmetic pH adjusters known to those skilled in the art, such as one or more of citric acid, sodium citrate, sodium lactate, malic acid, lactic acid, tartaric acid, phosphoric acid, and triethanolamine. The preservative may be selected from cosmetic preservatives known to those skilled in the art, such as one or more combinations of phenoxyethanol, ethylhexylglycerin, chlorphenesin, p-hydroxyacetophenone, and 1,2-hexanediol.

[0025] As a more preferred technical solution of the present invention, the skin conditioning agent is made from the following raw materials:

[0026]

[0027] In summary, the essence provided by this invention comprises the following components, by weight:

[0028]

[0029]

[0030] The Eight Treasures Essence includes extracts of Ligusticum chuanxiong root, Poria cocos sclerotium extract, Atractylodes macrocephala root, Bletilla striata root, Ampelopsis japonica root, artificial bezoar, pearl extract, and borneol. Among them, bezoar has certain antioxidant functions, borneol has antiseptic and tissue-regenerating effects, and pearl has the effects of improving eyesight, calming the mind, relieving wind, promoting tissue regeneration and healing sores. Combined with the five ingredients of Ampelopsis japonica, Bletilla striata, Atractylodes macrocephala, Poria cocos, and Ligusticum chuanxiong, it has good antioxidant and blood-activating effects, which can effectively prevent cell damage and repair the skin barrier.

[0031] Specifically, the composition of the Eight Treasures Essence in this invention is as follows: 0.8 wt% Ligusticum chuanxiong root extract, 0.5 wt% Poria cocos sclerotium extract, 0.5 wt% Atractylodes macrocephala root extract, 0.3 wt% Bletilla striata root extract, 0.3 wt% Ampelopsis japonica root extract, 0.05 wt% artificial bezoar, 1 wt% pearl extract, 0.05 wt% borneol, 1 wt% 1,2-hexanediol, 5 wt% butylene glycol, 0.5 wt% phenoxyethanol, 0.1 wt% ethylhexylglycerin, and 89.9 wt% water. The Eight Treasures Essence in this invention is obtained by mixing the above raw materials evenly, filtering, and sterilizing.

[0032] Among them, ginseng enzyme is made by fermenting ginseng with beneficial bacteria. The ginseng enzyme used in this invention is composed of butylene glycol, lactobacillus / ginseng root fermentation product filtrate, and hydrolyzed ginsenosides. The ginsenosides contained therein can disrupt the process of melanin cells transferring from the basal layer to the upper keratinocytes, inhibit the transfer of melanosomes to keratinocytes, and have a good whitening effect. Ginseng enzyme can also promote the proliferation and migration of normal fibroblasts, which helps wound healing and skin renewal. It can also inhibit the proliferation of scar fibroblasts, reduce scar formation in the process of wound healing, reduce skin atrophy caused by ultraviolet rays, and alleviate photoaging, thus having a good repair effect.

[0033] The above technical solution utilizes multiple targets, including hydration and moisturizing, promoting collagen synthesis, promoting cell proliferation, anti-glycation, and anti-oxidation, to deliver a good firming and anti-wrinkle effect to the product. The specific mechanism of action is as follows:

[0034] ① Hydration and moisturization: The product utilizes moisturizers and 4D hyaluronic acid to provide good hydration and moisturization.

[0035] ② Promotes collagen synthesis: Recombinant human collagen is a high-molecular-weight biological protein, highly similar to human collagen. It utilizes carefully selected fermented active molecules to form a protective film on the skin surface, reaching deep into the skin to replenish lost collagen and promote collagen synthesis. Hydroxypropyl tetrahydropyranotriol is a xylose derivative with anti-aging active ingredients that promotes collagen synthesis, making the epidermis and dermis more tightly connected, resulting in plump, firm, and more elastic skin. Glyceryl glucoside significantly promotes type I collagen synthesis. Acetyl hexapeptide-8 is a bioactive polypeptide that can reduce existing facial wrinkles and effectively prevent new wrinkles. By inhibiting the release of the neurotransmitter acetylcholine, it reduces muscle contraction, thereby reducing dynamic wrinkles and expression lines.

[0036] ③ Promotes cell proliferation: Angelica POLYMORPHA SINENSIS root extract exhibits anti-aging effects by inhibiting membrane lipid peroxidation and free radical reactions induced by superoxide free radicals, increasing the activation rate of luciferase, and promoting stem cell proliferation.

[0037] ④ Anti-glycation: Carnosine prevents protein damage by inhibiting glycation. It helps protect the skin's connective tissue, making the skin firm, smooth, and correcting and preventing wrinkles.

[0038] ⑤ Antioxidant: The lactobacillus / ginseng root fermentation product filtrate in ginseng enzymes has an inhibitory effect on keratinocyte apoptosis caused by ultraviolet rays. It can participate in resisting photoaging of keratinocytes through multiple pathways. It can also help the skin inhibit lipid peroxides and oxygen free radicals, effectively preventing skin tissue aging and degenerative changes. It can also restore skin elasticity and reduce wrinkles by protecting collagen in fibroblasts. The Eight Treasures Essence Original Liquid has the effect of scavenging DPPH free radicals and inhibiting tyrosinase and hyaluronidase, and has a good antioxidant effect.

[0039] Fifthly, the present invention also provides a method for preparing the above-mentioned essence, comprising the following steps:

[0040] (1) Add the first part of deionized water to the emulsification tank, then add the first thickener, the second thickener, recombinant human collagen, polyethylene glycol, moisturizer, and pH adjuster. After heating, vacuum stir and homogenize until all materials are dissolved to obtain material 1.

[0041] (2) After cooling down the material 1 obtained in step (1), add hydroxypropyl tetrahydropyranotriol, Babao Essence Original Liquid, acetyl hexapeptide-8, glyceryl glucoside, 4D hyaluronic acid and ginseng enzyme to the material 1, and then homogenize it under vacuum to obtain material 2.

[0042] (3) Dissolve carnosine and Angelica sinensis root extract in the second part of deionized water, filter and add to the material 2 obtained in step (2), and then homogenize after vacuum stirring to obtain material 3.

[0043] (4) Add polydimethylsiloxane to material 3 obtained in step (3), and homogenize it under vacuum to obtain material 4;

[0044] (5) Add the preservative to the material 4 obtained in step (4), stir under vacuum and homogenize until the material is evenly dissolved, stop stirring and age to obtain the essence.

[0045] As a more preferred technical solution of the present invention, in step (1), the temperature is raised to 60-65°C, the vacuum stirring speed is 30-50 r / min, the homogenization speed is 1000-2000 r / min, and the homogenization time is 10-15 min.

[0046] In step (2), the vacuum stirring speed is 30-50 r / min, the homogenization speed is 1000-2000 r / min, and the homogenization time is 3-5 min.

[0047] In step (3), the vacuum stirring speed is 30-50 r / min, the homogenization speed is 1000-2000 r / min, and the homogenization time is 3-5 min.

[0048] In step (4), the vacuum stirring speed is 30-50 r / min, the homogenization speed is 2000-2500 r / min, and the homogenization time is 5-10 min.

[0049] In step (5), the vacuum stirring speed is 35-45 r / min, the homogenization speed is 1000-2000 r / min, the homogenization time is 3-5 min, and the aging time is 12-36 h.

[0050] Compared with the prior art, the present invention has the following beneficial effects:

[0051] (1) The composition system provided by the present invention does not contain alcohol or emulsifiers, but uses high-concentration, low-cost polyethylene glycol as a solubilizer and a compounded polymer thickening suspension system. This not only stabilizes polydimethylsiloxane in the aqueous system, but also brings a refreshing and easily absorbed skin feel to the product through the volatility of polydimethylsiloxane. Moreover, its physicochemical properties are stable and its ingredients are simple and safe. When applied to water-based cosmetic products such as toners, serums and facial masks, it can avoid the irritation caused by the use of alcohol and emulsifiers in cosmetic products, significantly improve the viscosity of the system, and make the product have a faster absorption effect and a better skin feel.

[0052] (2) The essence provided by the present invention is made of selected active substances, which work together to achieve multiple targets such as moisturizing, promoting collagen synthesis, promoting cell proliferation, anti-glycation, and anti-oxidation, thus bringing good firming and anti-wrinkle effects to the product. Attached Figure Description

[0053] Figure 1 The comparison chart shows the anti-wrinkle effect of the subjects before using the product (BL), after 2 weeks of using the product (W2), and after 4 weeks of using the product (W4).

[0054] Figure 2 The images show the before-and-after comparison of the firming effect on the subjects before (BL), after 2 weeks of product use (W2), and after 4 weeks of product use (W4). Detailed Implementation

[0055] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0056] It should be noted that some material information in the embodiments of the present invention is as follows:

[0057] The Eight Treasures Essence used in this embodiment of the invention is produced by Mayinglong Health Industry Co., Ltd., and its composition and preparation method can be referred to the patent document with publication number CN115317429A.

[0058] The ginseng enzyme used in this embodiment of the invention is composed of butylene glycol, lactobacillus / ginseng root fermentation product filtrate, and hydrolyzed ginsenosides, and was purchased from Guangzhou Ganeng Biotechnology Co., Ltd.

[0059] The recombinant human collagen used in the embodiments of this invention was purchased from Jiangsu Jiangshan Juyuan Biotechnology Co., Ltd.

[0060] The carnosine used in the embodiments of this invention is commercially known as Carnosine.

[0061] The glycerol glucoside used in the embodiments of this invention is commercially known as Annoin.

[0062] The phenoxyethanol / ethylhexylglycerin used in the embodiments of this invention is commercially known as euxyl PE 9010.

[0063] Example 1

[0064] A composition for use in an aqueous cosmetic product, by weight comprising: 10 g of polyethylene glycol 400, 0.15 g of xanthan gum, 0.06 g of hydroxyethyl cellulose, 0.5 g of ammonium acryloyl dimethyl taurate / VP copolymer, 5 g of 1,5-viscosity polydimethylsiloxane, and deionized water to a final volume of 100 g.

[0065] In this embodiment, a method for preparing the composition is also provided, comprising the following steps:

[0066] (1) In a reactor, xanthan gum, hydroxyethyl cellulose, and ammonium acryloyl dimethyl taurate / VP copolymer were evenly dispersed in polyethylene glycol solution. Deionized water was added, and the mixture was stirred and heated to 70°C. The homogenization rate was 4000 r / min and the homogenization time was 8 min to ensure that the materials were completely dissolved.

[0067] (2) Cool down to 42°C, add polydimethylsiloxane to the reactor and homogenize and stir. The homogenization rate is 5500 r / min, the stirring speed is 40 rpm / min, and the stirring and homogenization time is 15 min. The product is ready for use.

[0068] Example 2

[0069] A composition for use in an aqueous cosmetic product, by weight comprising: 8 g of polyethylene glycol 400, 0.18 g of xanthan gum, 0.08 g of hydroxyethyl cellulose, 0.4 g of ammonium acryloyl dimethyl taurate / VP copolymer, 2.5 g of 1,5-viscosity polydimethylsiloxane, and deionized water to a final volume of 100 g.

[0070] In this embodiment, a method for preparing the composition is also provided, comprising the following steps:

[0071] (1) In a reactor, xanthan gum, hydroxyethyl cellulose, and ammonium acryloyl dimethyl taurate / VP copolymer were evenly dispersed in polyethylene glycol solution. Deionized water was added, and the mixture was stirred and heated to 70°C. The homogenization rate was 4000 r / min and the homogenization time was 8 min to ensure that the materials were completely dissolved.

[0072] (2) Cool down to 42°C, add polydimethylsiloxane to the reactor and homogenize and stir. The homogenization rate is 5500 r / min, the stirring speed is 40 rpm / min, and the stirring and homogenization time is 15 min. The product is ready for use.

[0073] Example 3

[0074] A serum with firming and anti-wrinkle effects, made from the following ingredients by weight (g):

[0075] Table 1 Raw materials prepared in Example 3

[0076]

[0077] In this embodiment, a method for preparing the above-mentioned essence is also provided, comprising the following steps:

[0078] (1) Add the deionized water in phase A to the emulsification tank, then add the remaining material, heat to 60°C, vacuum stir (40 r / min) and then homogenize (1500 r / min) for 15 min until all the material is dissolved to obtain material 1;

[0079] (2) After cooling down the material 1 obtained in step (1), add the B phase material to the material 1, vacuum stir (45 r / min) and then homogenize (2000 r / min) for 4 min to obtain material 2;

[0080] (3) Dissolve the carnosine and Angelica sinensis root extract in phase C in deionized water, filter and add to material 2 obtained in step (2), vacuum stir (45 r / min) and homogenize (1800 r / min) for 5 min to obtain material 3.

[0081] (4) Add D-phase polydimethylsiloxane to material 3 obtained in step (3), stir under vacuum (45 r / min) and then homogenize (2200 r / min) for 8 min to obtain material 4;

[0082] (5) Add phase E to material 4 obtained in step (4), stir under vacuum (40 r / min) and then homogenize (1200 r / min) for 4 min until the material is evenly dissolved. Stop stirring and age for 24 h to obtain the essence.

[0083] Example 4

[0084] A serum with firming and anti-wrinkle effects, made from the following ingredients by weight (g):

[0085] Table 2 Raw materials prepared in Example 4

[0086]

[0087] In this embodiment, a method for preparing the above-mentioned essence is also provided, comprising the following steps:

[0088] (1) Add the deionized water in phase A to the emulsification tank, then add the remaining material, heat to 60°C, vacuum stir (40 r / min) and then homogenize (1500 r / min) for 15 min until all the material is dissolved to obtain material 1;

[0089] (2) After cooling down the material 1 obtained in step (1), add the B phase material to the material 1, vacuum stir (45 r / min) and then homogenize (2000 r / min) for 4 min to obtain material 2;

[0090] (3) Dissolve the carnosine and Angelica sinensis root extract in phase C in deionized water, filter and add to material 2 obtained in step (2), vacuum stir (45 r / min) and homogenize (1800 r / min) for 5 min to obtain material 3.

[0091] (4) Add D-phase polydimethylsiloxane to material 3 obtained in step (3), stir under vacuum (45 r / min) and then homogenize (2200 r / min) for 8 min to obtain material 4;

[0092] (5) Add phase E to material 4 obtained in step (4), stir under vacuum (40 r / min) and then homogenize (1200 r / min) for 4 min until the material is evenly dissolved. Stop stirring and age for 24 h to obtain the essence.

[0093] Example 5

[0094] A serum with firming and anti-wrinkle effects, made from the following ingredients by weight (g):

[0095] Table 3 Raw materials prepared in Example 5

[0096]

[0097] In this embodiment, a method for preparing the above-mentioned essence is also provided, comprising the following steps:

[0098] (1) Add the deionized water in phase A to the emulsification tank, then add the remaining material, heat to 60°C, vacuum stir (40 r / min) and then homogenize (1500 r / min) for 15 min until all the material is dissolved to obtain material 1;

[0099] (2) After cooling down the material 1 obtained in step (1), add the B phase material to the material 1, vacuum stir (45 r / min) and then homogenize (2000 r / min) for 4 min to obtain material 2;

[0100] (3) Dissolve the carnosine and Angelica sinensis root extract in phase C in deionized water, filter and add to material 2 obtained in step (2), vacuum stir (45 r / min) and homogenize (1800 r / min) for 5 min to obtain material 3.

[0101] (4) Add D-phase polydimethylsiloxane to material 3 obtained in step (3), stir under vacuum (45 r / min) and then homogenize (2200 r / min) for 8 min to obtain material 4;

[0102] (5) Add phase E to material 4 obtained in step (4), stir under vacuum (40 r / min) and then homogenize (1200 r / min) for 4 min until the material is evenly dissolved. Stop stirring and age for 24 h to obtain the essence.

[0103] Comparative Example 1

[0104] The preparation method of Comparative Example 1 is basically the same as that of Example 3, except that polyethylene glycol 400 is not added to the raw materials.

[0105] Comparative Example 2

[0106] The preparation methods of Comparative Example 2 and Example 3 are basically the same, except that xanthan gum and hydroxyethyl cellulose are not added to the raw materials.

[0107] Comparative Example 3

[0108] The preparation method of Comparative Example 3 is basically the same as that of Example 3, except that the ammonium acryloyl dimethyl taurate / VP copolymer is not added to the raw materials.

[0109] Comparative Example 4

[0110] The preparation method of Comparative Example 4 is basically the same as that of Example 3, except that polydimethylsiloxane is not added to its raw materials.

[0111] Comparative Example 5

[0112] Comparative Example 5 is prepared in a manner that is basically the same as that described in Example 3, except that Angelica POLYMORPHA SINENSIS root extract is not added to its raw materials.

[0113] Comparative Example 6

[0114] The preparation method of Comparative Example 6 is basically the same as that of Example 3, except that ginseng enzyme is not added to its raw materials.

[0115] Experimental Example 1

[0116] According to the standard "QB / T 2660-2004 Toner", the sensory indicators, appearance, skin feel, and physicochemical properties (cold resistance and heat resistance) of the essences prepared in Examples 3 to 5 and Comparative Examples 1 to 4 were evaluated. The test results are shown in Table 4.

[0117] Table 4. Results of Physicochemical Properties Test

[0118]

[0119] Experimental Example 2

[0120] The present invention uses the serums prepared in Example 3 and Comparative Examples 5-6 as test products to conduct human efficacy evaluation tests to evaluate the anti-wrinkle and firming effects of the products.

[0121] 2.1 Evaluation Indicators

[0122] (1) Anti-wrinkle effect - wrinkle volume

[0123] Measuring instrument: Derma TOP-V3 rapid optical imaging system for skin (EO-TECH, France)

[0124] Measurement requirements: Acquire one image (front view) and analyze the image once.

[0125] Parameter explanation: The lower the value, the shallower the wrinkles in the test area (site), and the unit is mm3.

[0126] (2) Anti-wrinkle effect - dermal density

[0127] Measuring instrument: Ultrasound skin testing instrument Series SkinLab Combo (CORTEX TECHNOLOGY, Denmark).

[0128] Measurement requirement: 1 test.

[0129] Parameter explanation: The higher the value, the higher the dermal density and the higher the collagen content. Unit: dimensionless.

[0130] 2.2 Test Methods

[0131] Thirty healthy Chinese subjects aged 35–60 years with prominent nasolabial folds, fine lines under the eyes, and forehead wrinkles were selected and divided into three groups of 10 each. Each group used the test product for four consecutive weeks. Testing was conducted at two and four weeks of product use. Each subject was tested three times, and the average value was taken. Statistical analysis was then performed using SPSS software.

[0132] After cleansing their face in the morning and evening, participants should take an appropriate amount into their palm, apply it evenly to their face, and gently pat until absorbed. Throughout the testing period, participants should avoid prolonged sun exposure, outdoor sports, travel, etc., and should not use cosmetics or medications with similar effects to the product. Furthermore, participants should not change their daily skincare routine.

[0133] 2.3 Test Results

[0134] 2.3.1 Results of wrinkle volume test

[0135] The results of the nasolabial fold volume test before and after the subjects used the product are shown in Table 5, and the rate of change of nasolabial fold volume before and after using the product is shown in Table 6.

[0136] Table 5. Results of nasolabial fold volume test before and after product use (X±S, n=10)

[0137]

[0138] (Compared with before product use, *P<0.05, **P<0.01, ***P<0.001)

[0139] Table 6. Change rate of nasolabial fold volume after subjects used the product.

[0140] Test case Rate of change after 2 weeks of use (W2) Rate of change after 4 weeks of use (W4) Example 3 -46.67％ -55.24％ Comparative Example 4 -33.63％ -40.71％ Comparative Example 5 -31.31％ -17.37％

[0141] As shown in the table, after 2 weeks of testing with the product of Example 3, the volume of nasolabial folds decreased significantly by 46.67% (p<0.01), and after 4 weeks of testing with the product of Example 3, the volume of nasolabial folds decreased significantly by 55.24% (p<0.001). This indicates that the product of the present invention has a better anti-wrinkle effect, while the anti-wrinkle effect of the comparative product is significantly worse than that of the examples.

[0142] One subject was selected who used the product of Example 3 for 4 weeks. Images of the nasolabial folds collected were analyzed using software. (See attached image) Figure 1 The software identifies and marks the target area in the image. In a black and white image, wrinkles are represented by white lines; the fewer white lines in the marked area, the better the wrinkle improvement. In a sepia image, wrinkles are represented by red lines; the fewer red lines in the marked area, the better the wrinkle improvement. In a green image, wrinkles are represented by red lines; the fewer red lines in the marked area, the better the wrinkle improvement. Figure 1 It can be seen that after the subjects used the product of the present invention, their wrinkles were significantly reduced, and the product of the present invention has a good anti-wrinkle effect.

[0143] 2.3.2 Results of dermal density test

[0144] The results of the dermal density test on the cheeks of the subjects before and after using the product are shown in Table 7, and the rate of change in dermal density before and after using the product is shown in Table 8.

[0145] Table 7. Dermal density test results of subjects before and after product use (X±S, n=10)

[0146]

[0147] (Compared with before product use, *P<0.05, **P<0.01, ***P<0.001)

[0148] Table 8. Changes in dermal density after product use by the subjects.

[0149] Test case Rate of change after 2 weeks of use (W2) Rate of change after 4 weeks of use (W4) Example 3 15.5％ 27.31％ Comparative Example 4 11.72％ 20.28％ Comparative Example 5 9.84％ 15.86％

[0150] As shown in the table, after using the product of Example 3 for 2 weeks, the dermal density of the cheeks increased significantly by 15.50% (p<0.01), and after using the product of Example 3 for 4 weeks, the dermal density of the cheeks increased significantly by 27.31% (p<0.001). This indicates that the collagen content of the cheeks increased significantly after using the product of this example. The product of this example has a better firming effect, while the anti-wrinkle effect of the comparative product is significantly worse than that of the example.

[0151] One subject was selected who used the product of Example 3 for 4 weeks. Skin ultrasound comparison images were collected before and after use. See details below. Figure 2 In the diagram, different colors represent the energy intensity of ultrasound waves emitted from the skin. Yellow and bright areas indicate high intensity, while green and black indicate low intensity. More yellow and bright areas indicate higher dermal density and higher collagen content. Figure 2 It can be seen that after the subjects used the product of the present invention, the dermal density increased significantly and the collagen content also increased significantly, resulting in a good firming effect.

[0152] 2.3.3 Subjective Evaluation Results

[0153] Four weeks after the participants used the product, they were asked to fill out a questionnaire with options including strongly agree, somewhat agree, neither agree nor disagree, somewhat disagree, and strongly disagree. The satisfaction rate was calculated and the results are shown in Table 9. Satisfaction rate = (total number of participants who selected strongly agree or somewhat agree) ÷ total number of valid participants × 100%.

[0154] Table 9. Subjects' self-rated satisfaction results

[0155]

[0156] After 28 days of product use, no adverse reactions were observed in either the example or the comparative subjects. The subjects in the example were satisfied with the product's skin feel, moisturizing, firming, and anti-wrinkle effects, showing the highest level of satisfaction and the best product evaluation.

[0157] The applicant declares that the technical solution of this invention is illustrated through the above embodiments, but this invention is not limited to the above embodiments, that is, it does not mean that this invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of individual raw materials in the product of this invention, additions of auxiliary components, and selection of specific methods, all fall within the protection scope and disclosure scope of this invention.

Claims

1. The use of a composition in the preparation of an essence, characterized in that, The composition is prepared by weight of the following components: 0.5-20 parts polyethylene glycol, 0.5-10 parts polydimethylsiloxane, 0.05-0.5 parts first thickener, and 0.05-1.0 parts second thickener; The first thickener is a compound of xanthan gum and hydroxyethyl cellulose; The second thickener is ammonium acryloyldimethyl taurate / VP copolymer; The polyethylene glycol is selected from at least one of polyethylene glycol 200, polyethylene glycol 300, and polyethylene glycol 400; the mass ratio of xanthan gum to hydroxyethyl cellulose is 1:0.3~0.

8. The essence is prepared from the following raw materials in parts by weight: 0.05-30 parts skin conditioning agent, 0.5-10 parts moisturizer, 0.01-1 part pH adjuster, 0.1-2 parts preservative, and 40-90 parts deionized water; The skin conditioning agent is made from the following raw materials: ； The humectant is selected from one or more of glycerin, butylene glycol, 1,3-propanediol, and pentanediol; the pH adjuster is selected from one or more of citric acid, sodium citrate, sodium lactate, malic acid, lactic acid, tartaric acid, phosphoric acid, and triethanolamine; and the preservative is selected from one or more of phenoxyethanol, ethylhexylglycerin, chlorphenesin, p-hydroxyacetophenone, and 1,2-hexanediol.

2. An application of the serum according to claim 1, characterized in that, Includes the following steps: (1) Add the first part of deionized water to the emulsification tank, then add the first thickener, the second thickener, recombinant human collagen, polyethylene glycol, humectant, and pH adjuster. After heating, vacuum stir and homogenize until all materials are dissolved to obtain material 1. (2) After cooling down the material 1 obtained in step (1), add hydroxypropyl tetrahydropyranotriol, Babao Essence Original Liquid, acetyl hexapeptide-8, glyceryl glucoside, 4D hyaluronic acid and ginseng enzyme to the material 1, and then homogenize it under vacuum to obtain material 2. (3) Dissolve carnosine and Angelica sinensis root extract in the second part of deionized water, filter and add to the material 2 obtained in step (2), and then homogenize after vacuum stirring to obtain material 3. (4) Add polydimethylsiloxane to material 3 obtained in step (3), and homogenize it under vacuum to obtain material 4; (5) Add the preservative to the material 4 obtained in step (4), stir under vacuum and homogenize until the material is evenly dissolved, stop stirring and age to obtain the essence.

3. The application according to claim 2, characterized in that, In step (1), the temperature is raised to 60~65℃, the vacuum stirring speed is 30~50 r / min, the homogenization speed is 1000~2000 r / min, and the homogenization time is 10~15 min; In step (2), the vacuum stirring speed is 30~50 r / min, the homogenization speed is 1000~2000 r / min, and the homogenization time is 3~5 min; In step (3), the vacuum stirring speed is 30~50 r / min, the homogenization speed is 1000~2000 r / min, and the homogenization time is 3~5 min; In step (4), the vacuum stirring speed is 30~50 r / min, the homogenization speed is 2000~2500 r / min, and the homogenization time is 5~10 min; In step (5), the vacuum stirring speed is 35~45 r / min, the homogenization speed is 1000~2000 r / min, the homogenization time is 3~5 min, and the aging time is 12~36 h.

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