Micro-liquid injection system and method thereof

Abstract

The application provides a micro-liquid injection system and a method thereof, and relates to the technical field of medical devices, and solves the technical problem of inconvenient use of an injection device for subretinal drug injection used in the prior art. The system comprises an injection cylinder, a piston, a connecting hose, a transfusion connector, a needle, and a connecting piece. The piston is arranged in the injection cylinder. The injection cylinder is connected with the needle through the transfusion connector and the connecting hose. The injection cylinder is connected with a vitreous body cutting and ultrasonic emulsification integrated machine (hereinafter referred to as a vitreous body cutting machine) through the connecting piece. The application provides a micro-liquid injection system. By adding the transfusion connector, unidirectional conduction and instantaneous positive pressure can be generated, so that the injection of bubbles can be avoided as much as possible when an ophthalmologist or the like performs drug injection. The connecting hose is arranged between the injection cylinder and the needle, the distance between the injection cylinder and the needle is increased, and a nurse can observe the display on the syringe to remind the doctor of the drug injection amount.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a micro-liquid injection system and a method thereof. BACKGROUND

[0002] Submacular hemorrhage (SMH) is a serious complication associated with polypoidal choroidal vasculopathy (PCV), retinal arterial macroaneurysm (RAM), neovascular age-related macular degeneration (nAMD), and traumatic retinopathy. Blood accumulation between the retinal neuroepithelial layer and the retinal pigment epithelial (RPE) layer causes severe damage to the retina, which often leads to irreversible vision loss without early intervention. Therefore, SMH is increasingly attracting the attention of fundus disease ophthalmologists.

[0003] Many studies have evaluated intravitreal or subretinal injection of recombinant tissue plasminogen activator (rt-PA) for the treatment of SMH. Subretinal injection of rt-PA combined with pars plana vitrectomy (PPV) and vitreous cavity tamponade to replace SMH shows good prognosis and has become the standard treatment for SMH patients. The key step for the success of rt-PA injection treatment of SMH is that the surgical physician inserts the needle into the retina with a thickness of less than 1 mm, and accurately, uniformly and bubble-free injects the treatment drug between the retinal neuroepithelial layer and the pigment epithelial layer cells.

[0004] The injection device used in clinical practice for subretinal drug injection is a micro-instrument with fine and accurate scales. The injection device can be connected to the gas source of an ophthalmic treatment system, i.e., a vitrectomy and phacoemulsification integrated machine (hereinafter referred to as a vitrectomy machine). The gas source is controlled by the ophthalmologist to be opened or closed through the foot pedal of the vitrectomy machine, and the gas is introduced into the injection device to push the piston in the injection device to inject the drug into the patient's eye.

[0005] The applicant found that the prior art at least has the following technical problems:

[0006] (1) When performing drug injection, the ophthalmologist uses both hands to hold the barrel of the injection device and needs to concentrate on aiming at the injection site. The ophthalmologist controls the opening / closing of the gas source of the vitrectomy machine by using the foot pedal, and the operation is as follows: the ophthalmologist concentrates on aiming at the injection site, steps on the foot pedal, injects the drug into the patient's eye, stops stepping on the foot pedal, shifts the line of sight to observe the amount of drug in the syringe, concentrates on aiming at the injection site again to continue stepping on the foot pedal until the amount of drug injection meets the requirements;

[0007] (2) the injection device includes an injection needle and a syringe for containing the drug, the syringe is provided with a scale mark, the drug is pushed into the subretinal space from the vitreous route of the patient by using the syringe, sometimes the situation of injecting bubbles occurs when injecting the drug, and the bubble removal process of the eye is quite difficult;For example, in the silicone oil injection mode, the syringe piston is pushed to the end of the syringe, at this stage, because the syringe piston is made of rubber, when the foot pedal is loosened, the pressure is released, the piston will be squeezed and rebounded, and a vacuum area causing the liquid medicine to be sucked back into the syringe is generated, which increases the risk of bubble generation.

[0008] (3) the injection device is provided with a piston, the movement of the piston is realized by introducing and extracting gas into the syringe, compared with the method of extracting the liquid medicine by pulling the push rod in the syringe, the controllability is poor;During the extraction of the liquid medicine, if the operation is not careful, the front end of the injection device is not completely below the liquid level or the front end of the injection device is attached to the wall, bubbles will be generated, repeated suction of gas is needed to remove the bubbles, and the operation of repeated suction of gas to remove the bubbles is realized by the glass cutting machine, which is complicated and time-consuming;

[0009] (4) the operation process involved in the subretinal drug injection is completed in a dark room, the lighting system in the operating room often needs to be switched to see the scale line on the syringe by turning on the light and to perform the injection by turning off the light, so the above steps are repeated many times, which may cause insufficient or excessive injection of the liquid medicine, and medical errors or related serious complications are easy to occur. SUMMARY

[0010] The purpose of the present application is to provide a micro-liquid injection system and a method thereof, so as to solve the technical problem of inconvenient use of the injection device for subretinal drug injection in the prior art 。 The preferred technical solutions in the many technical solutions provided by the present application can produce many technical effects, which are described in detail below.

[0011] In order to achieve the above-mentioned purpose, the present application provides the following technical solutions.

[0012] The micro-liquid injection system provided by the present application comprises an injection syringe, a piston, a connecting hose, a liquid inlet connector, a needle and a connecting piece, wherein the injection syringe is provided with a piston, the injection syringe is connected with the needle through the liquid inlet connector and the connecting hose, and the injection syringe is connected with the glass cutting machine through the connecting piece.

[0013] Further, the injection syringe and the connecting piece are in an integrated structure, or the injection syringe and the connecting piece are detachably connected.

[0014] Further, one end of the syringe is formed with a connecting part, a through hole on the connecting part is in communication with the inside of the syringe, the connecting part is inserted into the connecting piece and the two are sealingly connected; or the connecting piece comprises a main body part and an insertion part, the insertion part is arranged on one side of the main body part and the two are connected, the insertion part is used to insert into the syringe and the two are sealingly connected.

[0015] Further, the connecting part is threadedly connected with the connecting piece; or a sealing ring is arranged on the connecting part or the connecting piece, the sealing ring is pressed between the connecting part and the connecting piece; a connecting plate is arranged on the connecting piece, the connecting plate is arranged on one end of the connecting piece and is arranged along the circumferential direction of the connecting piece, the connecting plate is used to be clamped on the joint end of the glass cutter.

[0016] Further, the micro-liquid injection system further comprises a push rod, the push rod is inserted into the syringe and connected with the piston, and the push rod is breakable.

[0017] Further, a breakage line is arranged on the push rod, the breakage line is arranged on the outer surface of the push rod along the length direction of the push rod and is spaced apart.

[0018] Further, the push rod comprises a push rod main body part and an end part, the two ends of the push rod main body part are connected with the piston and the end part respectively, the push rod main body part is a hollow cylindrical structure, and the end part is a thin plate.

[0019] Further, the micro-liquid injection system further comprises a lighting lamp and a pressure sensor, the lighting lamp is arranged on the connecting piece, the pressure sensor is arranged on the foot pedal of the glass cutter, and the lighting lamp and the pressure sensor are connected with a control device; when the signal value fed back by the pressure sensor is greater than a preset pressure value, the control device can control the lighting lamp not to emit light; when the signal value fed back by the pressure sensor is not greater than the preset pressure value, the control device can control the lighting lamp to emit light.

[0020] A use method of the micro-liquid injection system, comprising an injection system preparation process, and the process is as follows: the syringe is used to draw the push rod to suck medicine; after the medicine is sucked, the push rod is broken, the syringe is connected to the silicone oil injection and suction interface of the glass cutter through the connecting piece, or after the medicine is sucked, the push rod is broken after the infusion connector, the connecting hose and the needle are connected; the exhaust operation is performed during the connection of the infusion connector, the connecting hose and the needle.

[0021] Further, the exhaust operation is as follows: connecting the infusion connector to the syringe; opening the gas source of the push rod or glass cutter by pushing the push rod or glass cutter, and the drug liquid drops into the needle plug from the connecting hose; after the needle plug is filled with drug liquid, the needle is connected to the connecting hose; the push rod or glass cutter is pushed to open the gas source, and the treatment drug in the syringe is pushed to the appropriate amount, and the discharge of any visible bubbles is confirmed again to complete the preparation of the injection system.

[0022] The preferred technical scheme of the present application can at least produce one of the following technical effects:

[0023] The micro-liquid injection system provided by the present application increases the distance between the syringe and the needle by arranging a connecting hose between the syringe and the needle, so that during the operation, the ophthalmologist can concentrate on aiming at the injection site, and the nurse can observe the scale on the syringe to remind the ophthalmologist of the amount of drug injection.

[0024] The micro-liquid injection system provided by the present application increases the distance between the syringe and the needle by arranging a connecting hose between the syringe and the needle, so that during the operation, the ophthalmologist can concentrate on aiming at the injection site, and the nurse can observe the scale on the syringe to remind the ophthalmologist of the amount of drug injection.

[0025] In the prior art, the ophthalmologist may sometimes inject bubbles during drug injection, and the bubble removal process in the eye is quite difficult. The micro-liquid injection system provided by the present application can avoid the injection of bubbles during drug injection by the ophthalmologist by adding an infusion connector, which is unidirectional and can generate positive pressure instantaneously.

[0026] In order to further facilitate observation of the scale on the syringe, the thickness of the syringe can be increased, i.e. the capacity of the syringe ( 1ml-50ml ) is constant, increasing the thickness of the syringe can increase the diameter and surface area of the outer surface of the syringe, which can facilitate observation of the scale on the syringe.

[0027] The connecting piece and the syringe are connected by threads, which is convenient and fast, and the threaded connection can also achieve a sealing effect, and the threaded connection between the connecting piece and the syringe also facilitates cooperation with the push rod.

[0028] The needle includes two different specifications of needles, one of which is 38G-41G, used for ophthalmologists to pierce the needle into the vitreous body of the patient when performing drug injection; one of which can be 28G (of course, not limited to only 28G), used for extracting drugs, when it is needed to extract the liquid medicine into the inside of the syringe, the large specification needle is installed on the syringe, and then the extraction of the liquid medicine is realized by pulling the push rod upward. When the liquid medicine is extracted, the push rod needs to be broken to prevent affecting the connection of the syringe and the connecting piece.

[0029] The micro-liquid injection system also includes a lighting lamp, and the control device can control the working state of the lighting lamp according to the signal detected by the pressure sensor, and timely open and close the lighting lamp, so that the operation is quickly and efficiently performed;

[0030] In addition, the micro-liquid injection system provided by the application can not only be used for subretinal drug injection, but also can be used for neonatal liquid micro-injection, and is not limited to human bodies, but also can be animals. BRIEF DESCRIPTION OF DRAWINGS

[0031] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description only some embodiments of the application, and for those skilled in the art, other drawings can also be obtained without creative labor on the basis of these drawings.

[0032] Figure 1 It is a structural schematic diagram of a micro-liquid injection system according to an exemplary embodiment;

[0033] Figure 2 It is Figure 1 the local enlarged view of A in FIG. 4;

[0034] Figure 3 It is a structural schematic diagram of a micro-liquid injection system according to an exemplary embodiment;

[0035] Figure 4 It is Figure 3 the local enlarged view of B in FIG. 4;

[0036] Figure 5 It is a structural schematic diagram of a push rod according to an exemplary embodiment.

[0037] In the figure, 1 is a syringe; 2 is a piston; 3 is a connecting hose; 4 is a liquid infusion connector; 5 is a needle; 6 is a connecting piece; 7 is a connecting part; 8 is a connecting plate; 9 is a cylindrical part; 10 is a connecting block; 11 is a main body part; 12 is an insertion part; 13 is a lug; 14 is a clamping part; 15 is a push rod; DETAILED DESCRIPTION

[0038] In order to make the objects, technical solutions and advantages of the present application clearer, the technical solutions of the present application will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0039] Embodiment 1:

[0040] Referring to Figure 1 and Figure 3 , the present application provides a micro-liquid injection system, comprising an injection cylinder 1, a piston 2, a connecting hose 3, a transfusion connector 4, a needle 5 and a connecting piece 6, wherein the piston 2 is arranged in the injection cylinder 1, the injection cylinder 1 is connected with the needle 5 through the transfusion connector 4 and the connecting hose 3, and the injection cylinder 1 is connected with a glass cutting machine through the connecting piece 6.

[0041] When the injection device for subretinal drug injection in the prior art is used, since the injection cylinder 1 is directly connected with the needle 5, during the operation, the ophthalmologist concentrates on aiming at the injection site, steps on the foot pedal, injects the drug into the patient's eye, then stops stepping on the foot pedal, shifts the line of sight to observe the amount of drug in the syringe, concentrates on aiming at the injection site again to continue stepping on the foot pedal until the amount of drug injection reaches the requirement. During the operation, the line of sight of the ophthalmologist needs to be constantly switched between "aiming at the injection site" and "syringe indication", which not only affects the efficiency, but also increases the risk of surgery.

[0042] When the micro-liquid injection system provided by the present application is used, since the connecting hose 3 is arranged between the injection cylinder 1 and the needle 5, the distance between the injection cylinder 1 and the needle 5 is increased, so that during the operation, the ophthalmologist concentrates on aiming at the injection site, and the nurse can observe the indication on the syringe to remind the ophthalmologist of the amount of drug injection.

[0043] In addition, the operation process involved in subretinal drug injection is completed in a dark room, and the lighting system in the operating room often needs to be switched, so that the scale line on the needle cylinder can be seen by turning on the light and the injection can be performed by turning off the light, and this step is repeated many times, which is low in efficiency. Since the connecting hose is arranged between the injection cylinder and the needle in the micro-liquid injection system provided by the present application, the nurse can observe the indication on the syringe on one side through the lighting device, which solves the problem that the injection scale in the prior art cannot be clearly seen during the injection operation in the dark room, reduces the on-off operation of the light, improves the convenience of reading the injection dose during subretinal drug injection, and improves the safety of the injection operation.

[0044] The micro liquid injection system provided by the application has the advantages that the infusion connector 4 is arranged on the connecting hose 3 and can prevent backflow. When performing drug injection, an ophthalmologist uses both hands to hold the needle cylinder of the injection device and needs to concentrate on aiming at the injection site. The ophthalmologist controls the opening / closing of the gas source of the vitrector by using a foot pedal. When the ophthalmologist controls the opening of the gas source of the vitrector by using the foot pedal, the piston 2 in the injection cylinder 1 is pushed to move to one side of the connecting hose 3, and the drug is pushed into the connecting hose 3 and discharged from the needle 5. When the ophthalmologist controls the closing of the gas source of the vitrector by using the foot pedal, the infusion connector 4 is unidirectionally conducted and instantaneously generates positive pressure, so that the drug liquid in the connecting hose 3 cannot flow to the side of the injection cylinder 1, and further, the gas cannot enter through the needle 5.

[0045] In the prior art, when performing drug injection, the ophthalmologist may sometimes inject bubbles, and the bubble discharge process of the eye is quite difficult. The micro liquid injection system provided by the application can avoid the injection of bubbles when the ophthalmologist performs drug injection by adding the infusion connector, which is unidirectionally conducted and can instantaneously generate positive pressure. The front end of the infusion connector has a separation membrane made of a high-efficiency polymer material, such as a white elastic silicon cap, which has good sealing performance and can effectively prevent the penetration of gas, liquid, bacteria and cross infection. The infusion connector can be unidirectionally conducted and instantaneously generate positive pressure.

[0046] In order to further facilitate the observation of the indication on the injection cylinder 1, the thickness of the injection cylinder 1 can be increased, that is, the capacity (1ml-50ml) of the injection cylinder 1 is unchanged, and the thickness of the injection cylinder 1 is increased, that is, the diameter and surface area of the outer surface of the injection cylinder 1 are increased, which can facilitate the observation of the indication on the injection cylinder 1.

[0047] Regarding the structure of the connecting piece 6 and the connecting structure between the connecting piece 6 and the injection cylinder 1, the injection cylinder 1 and the connecting piece 6 are integrated or the injection cylinder 1 and the connecting piece 6 are detachably connected. That is, the injection cylinder 1 and the connecting piece 6 are integrally formed, or the injection cylinder 1 and the connecting piece 6 can be detachably connected.

[0048] Referring to Figure 3 and Figure 4 , the injection cylinder 1 and the connecting piece 6 are detachably connected, which can be as follows:

[0049] One end of the injection cylinder 1 is formed with a connecting part 7, a through hole on the connecting part 7 is in communication with the inside of the injection cylinder 1, and the connecting part 7 is inserted into the connecting piece 6 and sealingly matched with the connecting piece 6.

[0050] As to the sealing fit, the following can be specifically used: the connecting piece 6 and the injection cylinder 1 are connected by threads, which is convenient and fast, and the threaded connection can also have a sealing effect; or, a sealing ring is arranged on the connecting part 7 or the connecting piece 6, the sealing ring is pressed between the connecting part 7 and the connecting piece 6, and through the sealing ring, the connecting part 7 can be fixed on the connecting piece 6 and sealing can be realized.

[0051] Referring to Figure 4 , the connecting piece 6 is provided with a connecting plate 8, the connecting plate 8 is arranged at one end of the connecting piece 6 and along the circumferential direction of the connecting piece 6, and the connecting plate 8 is used to be clamped on the joint end of the glass cutting machine. As to the connection mode of the connecting piece 6 and the joint end of the glass cutting machine, it is the same as the prior art, and thus it is not necessary to repeat it here.

[0052] Referring to Figure 4 , the connecting piece 6 includes a cylindrical part 9 and a connecting block 10, the connecting block 10 is arranged in the cylindrical part 9 and located away from the connecting plate 8, the outer circumferential side of the connecting block 10 is connected with the inner side of the cylindrical part 9, a threaded hole is arranged on the connecting block 10, and an external thread is arranged on the connecting part 7 of the injection cylinder 1, the connecting part 7 is inserted into the threaded hole of the connecting block 10 and the two are threadedly connected.

[0053] The cylindrical part 9, the connecting block 10 and the connecting piece 6 are preferably integrally cast.

[0054] Referring to Figure 1 and Figure 2 , as to the structure of the connecting piece 6 and the connection structure between the connecting piece 6 and the injection cylinder 1, the following can also be used:

[0055] The connecting piece 6 includes a main body part 11 and an insertion part 12, the insertion part 12 is arranged at one side of the main body part 11 and connected with the main body part 11, the main body part 11 and the insertion part 12 are preferably integrally cast, the insertion part 12 is used to be inserted into the injection cylinder 1 and the two are sealingly fitted, an airflow channel is formed on the main body part 11 and the insertion part 12, and the lugs 13 on the injection cylinder 1 are clamped on the main body part 11.

[0056] A sealing ring is arranged on the insertion part 12, the insertion part 12 is inserted into the injection cylinder 1 and sealingly fitted with the inner side wall of the injection cylinder 1.

[0057] Two clamping parts 14 are arranged on the main body part 1, the two clamping parts 14 are symmetrically distributed on both sides of the main body part 1, and the lugs 13 are clamped between the clamping parts 14 and the main body part 1. Referring to Figure 2 , it is shown that the two lugs 13 of the injection cylinder 1 are clamped between the clamping parts 14 and the main body part 1. During installation, the insertion part 12 can be inserted into the injection cylinder 1 first, and then the injection cylinder 1 is rotated so that the two lugs 13 on the injection cylinder 1 are clamped on the corresponding clamping parts 14.

[0058] Referring toFigure 2 The connecting plate 8 is arranged on the body part 11 and at one end of the body part 11 and along the circumferential direction of the body part 11, and is used to be clamped on the joint end of the glass cutting machine.

[0059] Embodiment 2:

[0060] Different from embodiment 1, the micro liquid injection system further comprises a lighting lamp arranged on the connecting piece 6, and a pressure sensor arranged on the foot pedal, and the lighting lamp and the pressure sensor are connected with the control device. The control device is arranged on the glass cutting machine. The control device can control the working state of the lighting lamp according to the signal detected by the pressure sensor.

[0061] For example, when an ophthalmologist performs drug injection, first, the ophthalmologist turns on the switch connected with the lighting lamp, and when the ophthalmologist steps on the foot pedal to control the opening of the gas source of the glass cutting machine, the pressure sensor transmits the detected signal to the control device, and the control device controls the lighting lamp not to emit light. When the ophthalmologist does not step on the foot pedal to control the closing of the gas source of the glass cutting machine, the pressure sensor transmits the detected signal to the control device, and the control device controls the lighting lamp to emit light. At this time, the nurse can read the indication on the syringe 1 through the light emitted by the lighting lamp. That is, the control device controls the lighting lamp not to emit light according to the signal fed back by the pressure sensor if the signal value fed back by the pressure sensor is greater than the preset pressure value, and controls the lighting lamp to emit light if the signal value fed back by the pressure sensor is not greater than the preset pressure value.

[0062] By adopting the above structure, the lighting lamp can be turned on and off in time according to the operation process of the operation, so that the operation can be carried out quickly and efficiently.

[0063] The pressure sensor and the control device can adopt the prior art, which will not be described in detail here.

[0064] As for the connection and distribution of the lighting lamp and the connecting piece 6, the lighting lamp can be pasted on the connecting piece 6, and one lighting lamp is arranged on the side of the indication of the syringe 1. Of course, a plurality of lighting lamps can also be arranged along the circumferential direction of the connecting piece 6.

[0065] As for the connection mode of the lighting lamp and the connecting piece 6, the preferred mode is detachable connection. For example, elastic clamps are arranged on the outer circumferential side wall of the connecting piece 6, and the connecting line connected with the lighting lamp is fastened on the connecting piece 6 through the elastic clamps, so that the lighting lamp can be connected on the connecting piece 6 when needed, and can be detached from the connecting piece 6 when not needed.

[0066] Embodiment 3:

[0067] Unlike the embodiment 1, the micro-liquid injection system further comprises a push rod 15, which is inserted into the injection cylinder 1 and connected with the piston 2, and the push rod 15 is breakable. See Figure 5 By using the push rod 15, the drug liquid can be easily drawn into the injection cylinder 1.

[0068] The needle 5 comprises two different specifications of needles, one of which is 38G-41G, for example, a 40G needle can be selected to be used for the ophthalmologist to pierce the needle into the vitreous body of the patient when performing drug injection; and one of which can be 28G (of course, not limited to only 28G in size), which is used to draw the drug. When the drug liquid needs to be drawn into the injection cylinder 1, the large-size needle is installed on the injection cylinder 1, and then the push rod 15 is pulled upward to achieve the drawing of the drug liquid. After the drug liquid is drawn, the push rod 15 can also be used to remove the air bubbles, and the push rod 15 is pushed downward to remove the air bubbles in the injection cylinder 1.

[0069] To remove the air bubbles in the injection cylinder 1, the push rod 15 needs to be broken to prevent affecting the connection of the injection cylinder 1 and the connecting piece 6, the connecting hose 3 and the infusion connector 4 are connected to the injection cylinder 1, and the small-size needle is installed on the connecting hose 3. Specifically, the push rod 15 is broken, the injection cylinder 1 is connected with the connecting piece 6, the connecting hose 3 and the infusion connector 4 are connected to the injection cylinder 1, the gas source of the vitrector is opened, the piston is pushed to make the drug liquid flow out through the connecting hose 3, the small-size needle is used to receive the drug liquid, and then the small needle is installed on the connecting hose 3.

[0070] Alternatively, after the drug liquid is drawn, the push rod 15 is not broken, the connecting hose 3 and the infusion connector 4 are connected to the injection cylinder 1, and then the small-size needle is installed on the connecting hose 3. The push rod 15 is pushed to remove part of the drug liquid through the connecting hose 3 and the small needle to achieve air removal. Then the push rod 15 is broken, the injection cylinder 1 is connected with the connecting piece 6, and the air removal operation is simple.

[0071] Subretinal injection has been widely carried out, and is currently mainly used for: (1) rt-PA subretinal injection; (2) genetic therapy drug subretinal injection for ocular fundus lesions such as inherited retinal diseases (IRDs); (3) physiological saline subretinal injection; (4) RPE cell suspension or RPE membrane subretinal injection. The push rod design can facilitate the drawing of the drug liquid in the ampoule or the sterile drug liquid cup, and can prevent air bubbles from being easily generated during the drawing step.

[0072] Regarding the push rod 15, see Figure 5The push rod 15 is provided with a breaking line, which is distributed on the outer surface of the push rod 15 along the length direction of the push rod 15. The breaking line can facilitate the breaking of the push rod 15 along the breaking line. The distance between two adjacent breaking lines matches the 0.1ml small scale on the syringe 1.

[0073] The material of the push rod 15 is preferably glass or plastic.

[0074] The specific structure of the push rod 15 is described in detail in Figure 5 The push rod 15 includes a push rod main body and an end part. The two ends of the push rod main body are connected with the piston 2 and the end part respectively. The push rod main body is a hollow cylindrical structure, and the end part is a thin plate.

[0075] If the structure of the connecting piece 6 and the connection structure between the connecting piece 6 and the syringe 1 adopt the structure shown in Figure 3 and Figure 4 , the following is the implementation process:

[0076] After the extraction of the liquid medicine is completed, the push rod 15 needs to be broken, and the push rod 15 is almost flush with the connecting part 7 on the syringe 1. The connecting part 7 is inserted into the connecting piece 6 to realize the threaded connection of the two. The gas provided by the glass cutting machine can enter the content of the push rod 15 through the connecting piece 6, and the gas in the push rod 15 acts on the piston arranged at the end part of the push rod 15 to push the piston to move.

[0077] If the structure of the connecting piece 6 and the connection structure between the connecting piece 6 and the syringe 1 adopt the structure shown in Figure 1 and Figure 2 , the following is the implementation process:

[0078] After the extraction of the liquid medicine is completed, the push rod 15 needs to be broken, and the push rod 15 is almost flush with the syringe 1. The insertion part 12 of the connecting piece 6 is inserted into the syringe 1 and the two are sealingly matched, the push rod 15 is inserted into the airflow channel on the insertion part 12, and the lug 13 on the syringe 1 is clamped on the main body 11. The gas provided by the glass cutting machine can enter the content of the push rod 15 through the connecting piece 6, and the gas in the push rod 15 acts on the piston arranged at the end part of the push rod 15 to push the piston to move.

[0079] Example 4:

[0080] A method for using a micro-liquid injection system, including a preparation process of the injection system, the process is as follows:

[0081] The injection cylinder 1 uses the pull-push rod 15 to suck medicine; after sucking the medicine, the push rod 15 is broken, the injection cylinder 1 is connected to the silicone oil injection interface of the glass cutting machine through the connecting piece 6, or after sucking the medicine, the push rod 15 is broken after connecting the infusion connector 4, the connecting hose 3 and the needle 5; the exhaust operation is performed during the connection of the infusion connector 4, the connecting hose 3 and the needle 5.

[0082] The exhaust operation is as follows: the infusion connector 4 is connected to the injection cylinder 1; the medicine liquid flowing out of the connecting hose 3 is pushed into the needle plug by pushing the push rod 15 or opening the gas source of the glass cutting machine; after the needle plug is filled with medicine liquid, the needle 5 is connected to the connecting hose 3; the treatment medicine in the injection cylinder 1 is pushed to the appropriate amount by pushing the push rod 15 or opening the gas source of the glass cutting machine, and any visible bubbles are confirmed to be discharged again, and the preparation of the injection system is completed.

[0083] Regarding "the injection cylinder 1 uses the pull-push rod 15 to suck medicine", the specific actual operation is as follows:

[0084] For example, the medicine liquid is sucked from a sealed bottle, the injection cylinder 1 is connected to the needle 5 (the type of the medicine suction needle needs to be determined), the bottle plug is conventionally sterilized, the needle 5 is inserted into the bottle plug, the bottle is filled with the required amount of air to increase the pressure in the bottle, to avoid negative pressure, the bottle and the syringe are turned over, the needle 5 is below the liquid surface, then the required amount of medicine is sucked, the index finger is fixed on the needle plug, and the needle is pulled out. Then the needle 5 is pulled upward, the push rod 15 is pulled slightly to make the medicine liquid in the needle 5 flow into the injection cylinder 1, and the bubbles are gathered at the nipple port, and the push rod 15 is slightly pushed to drive out the gas;

[0085] For example, the medicine liquid is sucked from an ampoule bottle, the medicine liquid in the ampoule bottle is popped to the body part; after sterilizing the neck part of the ampoule, a saw mark is made, and after sterilizing again, the push rod 15 is broken, the needle 5 of the injection cylinder 1 is placed obliquely below the liquid surface, and the push rod 15 is pulled slightly to suck the medicine liquid;

[0086] If the medicine liquid is placed in a sterile open container, the nipple end of the injection cylinder 1 is placed in the medicine liquid, and the push rod 15 is pulled slightly to suck the required amount of medicine.

[0087] Regarding the injection system preparation process, if the push rod 15 is broken first, the specific operation is as follows:

[0088] The injection cylinder 1 uses the pull-push rod 15 to suck medicine;

[0089] After sucking the medicine, the push rod 15 is broken at the tail end of the injection cylinder 1, the tail end of the injection cylinder 1 is connected to the connecting piece 6 (or an integrated injection cylinder and connecting piece is used), and the connecting piece 6 is connected to the silicone oil injection interface of the ophthalmic treatment system-glass cutting and ultrasonic emulsification integrated machine;

[0090] Connect the infusion hub 4 with the syringe nipple end (Note: Keep the outer surface of the syringe nipple end dry before connection), set the maximum bolus pressure to 12-16mmHg in the silicone oil infusion mode of the vitreous cutting machine (In the silicone oil infusion mode, the opening / closing of the gas source of the vitreous cutting machine can be controlled by the foot pedal), and let the drug solution out of the end of the connecting hose 3 away from the infusion hub 4;

[0091] Drop the drug solution into the needle plug of the subretinal micro-injection needle, and complete the connection of the connecting hose 3 with the subretinal micro-injection needle 5 in the silicone oil infusion mode after the needle plug is filled with the drug solution;

[0092] In the silicone oil infusion mode of the vitreous cutting machine, adjust the bolus pressure to 8-10mmHg, control the foot pedal, push the therapeutic drug in the syringe 1 to the appropriate amount, and confirm again that any visible bubbles are discharged, and complete the preparation of the subretinal injection system.

[0093] Regarding the preparation process of the injection system, if the push rod 15 is not broken first, the specific operation is as follows:

[0094] Pull the push rod 15 to suck the drug in the syringe 1;

[0095] Connect the infusion hub 4 with the syringe nipple end (Note: Keep the outer surface of the syringe nipple end dry before connection), push the push rod 15, and let the drug solution out of the end of the connecting hose 3 away from the infusion hub 4;

[0096] Drop the drug solution into the needle plug of the subretinal micro-injection needle, and complete the connection of the connecting hose 3 with the subretinal micro-injection needle 5 in the silicone oil infusion mode after the needle plug is filled with the drug solution;

[0097] Push the therapeutic drug in the syringe 1 to the appropriate amount, and confirm again that any visible bubbles are discharged;

[0098] Break the push rod 15 at the position flush with the tail end of the syringe 1, connect the tail end of the syringe 1 with the connecting piece 6, connect the connecting piece 6 with the silicone oil infusion and aspiration interface of the ophthalmic treatment system, the vitreous cutting and ultrasonic emulsification integrated machine, and complete the preparation of the subretinal injection system.

[0099] Regarding the steps of subretinal injection of the drug, the specific operation is as follows:

[0100] (1) Insert the tip of the syringe needle loaded with the therapeutic drug into the subretinal space at a point with sufficient subretinal hemorrhage;

[0101] (2) In the silicone oil infusion mode, set the maximum bolus pressure to 8-10mmHg, control the foot pedal, and slowly infiltrate and inject the appropriate amount of therapeutic drug into the subretinal space according to the method described above;

[0102] (3) During the injection process, the scrub nurse holds the end of the silicone oil injection and suction interface in the pot belly part with the right hand index finger and thumb in the crab pincer shape, fixes the syringe with the index finger and thumb, ensures the stable connection of the syringe and the control pipeline, holds the injection cylinder and the infusion connector interface end with the left hand, and pays attention to the injection volume of the liquid medicine in the syringe at any time;

[0103] (4) After the subretinal injection operation at one point is completed, the subretinal micro-injection needle can be moved to other injection points to achieve the required treatment purpose of the liquid medicine dose;

[0104] (5) After the subretinal injection treatment is completed, the infusion connector is disconnected from the syringe, and then the subretinal micro-injection needle is removed.

[0105] In the description of the present application, it should be noted that, unless otherwise specified, the meaning of "a plurality of" is two or more; the orientations or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail" and the like are based on the orientations or positional relationships shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and are not intended to indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third" and the like are only for the purpose of description and cannot be understood as indicating or implying relative importance.

[0106] In the description of the present application, it should also be noted that, unless otherwise specified and limited, the terms "mounting", "connecting", "connecting" should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or integrally connected; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0107] In the description of the present application, the description of the terms "one embodiment", "some embodiments", "example", "specific example" or "one example" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In the present application, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0108] The above merely illustrates the specific embodiments of the present application, but the protection scope of the present application is not limited thereto, any person skilled in the art can easily think of the changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A micro-liquid injection system characterized by, The injection system comprises a syringe (1), a piston (2), a connecting hose (3), an infusion connector (4), a needle (5) and a connecting piece (6), wherein, The syringe (1) is provided with the piston (2), and the syringe (1) is connected with the needle (5) through the infusion connector (4) and the connecting hose (3), and the syringe (1) is connected with the glass cutting machine through the connecting piece (6); The micro-liquid injection system further comprises a push rod (15), the push rod (15) is inserted into the syringe (1) and connected with the piston (2), and the push rod (15) is breakable; The push rod (15) is provided with a breakage line on the outer surface thereof, and the breakage line is distributed along the length direction of the push rod (15); The push rod (15) comprises a push rod main body part and an end part, two ends of the push rod main body part are connected with the piston (2) and the end part respectively, the push rod main body part is a hollow cylindrical structure, and the end part is in the form of a thin plate.

2. A micro-liquid injection system according to claim 1, wherein The syringe (1) and the connecting piece (6) are in an integrated structure or detachably connected.

3. The micro-liquid injection system of claim 1, wherein One end of the syringe (1) is formed with a connecting part (7), a through hole in the connecting part (7) is in communication with the inside of the syringe (1), the connecting part (7) is inserted into the connecting piece (6) and the two are sealingly connected; or, The connecting piece (6) comprises a main body part (11) and an insertion part (12), the insertion part (12) is arranged on one side of the main body part (11) and connected with the main body part (11), and the insertion part (12) is used for being inserted into the syringe (1) and sealingly connected with the syringe (1).

4. A micro-liquid injection system according to claim 3, wherein The connecting part (7) and the connecting piece (6) are threadedly connected; or, a sealing ring is arranged on the connecting part (7) or the connecting piece (6), and the sealing ring is pressed between the connecting part (7) and the connecting piece (6); The connecting piece (6) is provided with a connecting plate (8), the connecting plate (8) is arranged at one end of the connecting piece (6) and arranged along the circumferential direction of the connecting piece (6), and the connecting plate (8) is used for being clamped on the connector end of the glass cutting machine.

5. The micro-liquid injection system of claim 1, wherein The micro-liquid injection system further comprises a lighting lamp and a pressure sensor, the lighting lamp is arranged on the connecting piece (6), the pressure sensor is arranged on the foot pedal of the glass cutting machine, and the lighting lamp and the pressure sensor are connected with a control device; when the signal value fed back by the pressure sensor is greater than a preset pressure value, the control device can control the lighting lamp not to emit light; when the signal value fed back by the pressure sensor is not greater than the preset pressure value, the control device can control the lighting lamp to emit light.

6. A method of using the micro-liquid injection system of any one of claims 1-5, wherein, The injection system preparation process comprises the following steps: The syringe (1) is used to draw the push rod (15) to suck medicine; After the medicine is sucked, the push rod (15) is broken, and the syringe (1) is connected to the silicone oil suction interface of the glass cutting machine through the connecting piece (6), or after the medicine is sucked, the push rod (15) is broken after the infusion connector (4), the connecting hose (3) and the needle (5) are connected; The venting operation is performed during the connection of the infusion connector (4), the connecting hose (3) and the needle (5).

7. The method of claim 6, wherein, The venting operation is as follows: The infusion connector (4) is connected to the syringe (1); The needle (5) is connected to the connecting hose (3) after the needle plug is filled with the drug solution; The syringe (1) is filled with the appropriate amount of the therapeutic drug by pushing the plunger (15) or opening the gas source of the glass cutter, and any visible air bubbles are checked again to complete the preparation of the injection system. ​

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