Feed additive for replenishing qi and promoting estrus for cows and preparation method thereof

Abstract

This invention provides a feed additive for cows that replenishes qi and promotes estrus. By weight, it comprises 50-100 parts of Eucommia ulmoides leaf extract, 20-50 parts of Angelica sinensis extract, 20-50 parts of Ligusticum chuanxiong extract, 20-50 parts of Astragalus membranaceus extract, 30-50 parts of Glycyrrhiza uralensis extract, 20-40 parts of soy isoflavones, 30-60 parts of yeast iron, 20-50 parts of vitamin E, and 640-690 parts of bentonite. The yeast iron and vitamin E are coated with palm oil. This feed additive for cows combines traditional Chinese medicine with soy isoflavones and yeast iron, which can improve the release of the medicinal effects of the traditional Chinese medicine and the body's absorption capacity, enhancing the effect of replenishing qi and blood. It achieves the purpose of promoting estrus through replenishing qi and blood, and its effect is relatively rapid.

Description

Technical Field

[0001] This invention relates to the technical field of feed additives, specifically to a feed additive for cows that replenishes qi and promotes estrus, and its preparation method. Background Technology

[0002] Under normal circumstances, a cow can only give birth to one calf per year. However, due to unscientific feeding and management practices and untimely disease diagnosis, some farmers have experienced serious adverse consequences for cattle farming, such as cows not coming into estrus after calving, miscarriages during pregnancy, frequent reproductive diseases, and decreased immunity after calving.

[0003] Currently, the main technologies for solving this problem include the following: 1. The most mainstream method is to inject cows with chemical drugs and sex hormones to increase estrus rate. This method is fast-acting, but it only treats the symptoms and not the root cause, has significant side effects, and the body can develop drug resistance during use, leading to increasingly poor drug efficacy. Moreover, drug residues can enter the human body through ingestion, thus affecting human health; 2. Using traditional Chinese medicine to promote estrus and improve the cow's resistance. This method has no toxic side effects, but it is slow to take effect. In today's intensive farming environment that requires high efficiency, it has obvious drawbacks, and the quality of traditional Chinese medicine varies, making it difficult to determine the product's effectiveness; 3. Adding sufficient vitamins and trace elements to supplement the body's required nutrients in order to increase estrus rate. However, this method is only suitable for groups with nutrient deficiencies and is not suitable for all groups.

[0004] There is an urgent market demand for a safe, stable, and fast-acting product to induce estrus and improve the immunity of cows. Therefore, existing technologies need further development. Summary of the Invention

[0005] The purpose of this invention is to overcome the above-mentioned technical deficiencies and provide a feed additive for inducing estrus in cows and its preparation method, so as to solve the technical problem of slow effect of feed additives for inducing estrus in cows in related technologies.

[0006] To achieve the above technical objectives, the present invention adopts the following technical solution: It provides a feed additive for cows to replenish qi and promote estrus, comprising, by weight parts: 50-100 parts of Eucommia ulmoides leaf extract, 20-50 parts of Angelica sinensis extract, 20-50 parts of Ligusticum chuanxiong extract, 20-50 parts of Astragalus membranaceus extract, 30-50 parts of Glycyrrhiza uralensis extract, 20-40 parts of soybean isoflavones, 30-60 parts of yeast iron, 20-50 parts of vitamin E, and 640-690 parts of bentonite. The yeast iron is yeast iron coated with palm oil, and the vitamin E is vitamin E coated with palm oil.

[0007] Furthermore, the ratio of soybean isoflavones to yeast iron, by mass, is 2-5:5.

[0008] Furthermore, the ratio of soy isoflavones to yeast iron is 4:5 by mass.

[0009] Furthermore, based on mass fractions, the total amount of Eucommia ulmoides leaf extract, Angelica sinensis extract, Ligusticum chuanxiong extract, Astragalus membranaceus extract, and Glycyrrhiza uralensis extract is used in a ratio of 4-6:1 to the amount of yeast iron.

[0010] Furthermore, by weight, it consists of 100 parts of Eucommia ulmoides leaf extract, 40 parts of Angelica sinensis extract, 30 parts of Ligusticum chuanxiong extract, 40 parts of Astragalus membranaceus extract, 30 parts of Glycyrrhiza uralensis extract, 40 parts of soybean isoflavones, 50 parts of yeast iron, 30 parts of vitamin E, and 640 parts of bentonite.

[0011] Furthermore, by weight, it consists of 50 parts of Eucommia ulmoides leaf extract, 50 parts of Angelica sinensis extract, 20 parts of Ligusticum chuanxiong extract, 20 parts of Astragalus membranaceus extract, 50 parts of Glycyrrhiza uralensis extract, 20 parts of soybean isoflavones, 60 parts of yeast iron, 50 parts of vitamin E, and 680 parts of bentonite.

[0012] Furthermore, by weight, it consists of 80 parts of Eucommia ulmoides leaf extract, 20 parts of Angelica sinensis extract, 50 parts of Ligusticum chuanxiong extract, 50 parts of Astragalus membranaceus extract, 30 parts of Glycyrrhiza uralensis extract, 30 parts of soybean isoflavones, 30 parts of yeast iron, 20 parts of vitamin E, and 690 parts of bentonite.

[0013] Further, the preparation steps of the Eucommia ulmoides leaf extract are as follows: Eucommia ulmoides leaves are decocted in water for 150-200 minutes, then filtered and spray-dried to obtain Eucommia ulmoides leaf extract; the preparation steps of the Angelica sinensis extract are as follows: Angelica sinensis is decocted in water for 90-120 minutes, then filtered and spray-dried to obtain Angelica sinensis extract; the preparation steps of the Ligusticum chuanxiong extract are as follows: Ligusticum chuanxiong is decocted in water for 120-150 minutes, then filtered and spray-dried to obtain Ligusticum chuanxiong extract; the preparation steps of the Astragalus membranaceus extract are as follows: Astragalus membranaceus is decocted in water for 120-150 minutes, then filtered and spray-dried to obtain Astragalus membranaceus extract; the preparation steps of the Glycyrrhiza uralensis extract are as follows: Glycyrrhiza uralensis is decocted in water for 120-150 minutes, then filtered and spray-dried to obtain Glycyrrhiza uralensis extract.

[0014] In addition, the present invention also provides a method for preparing the above-mentioned feed additive for cows that replenishes qi and promotes estrus. The preparation method is as follows: Eucommia ulmoides leaf extract, Angelica sinensis extract, Ligusticum chuanxiong extract, Astragalus membranaceus extract, Glycyrrhiza uralensis extract, soybean isoflavones, yeast iron, vitamin E, and bentonite are mixed in a three-dimensional mixer for 10-20 minutes.

[0015] Furthermore, the extracts of Eucommia ulmoides leaves, Angelica sinensis, Ligusticum chuanxiong, Astragalus membranaceus, Glycyrrhiza uralensis, soy isoflavones, yeast iron, vitamin E, and bentonite were each sieved through a 60-mesh sieve before mixing.

[0016] Beneficial effects:

[0017] 1. This invention provides a feed additive for cows that replenishes qi and promotes estrus. It combines traditional Chinese medicine with soy isoflavones and yeast iron. Experiments have shown that soy isoflavones can increase blood flow and accelerate blood circulation. Iron is an essential trace element in blood, and the addition of yeast iron can improve the body's hematopoietic function and accelerate blood circulation. Through the above methods, soy isoflavones and yeast iron can enable the body to absorb the effective components of traditional Chinese medicine more quickly and fully, thereby enhancing the release of the efficacy of traditional Chinese medicine and improving the effect of replenishing qi and blood. This achieves the purpose of promoting estrus through replenishing qi and blood, and the effect is relatively fast.

[0018] 2. The soy isoflavones and yeast iron used in this invention work synergistically. Soy isoflavones can enhance the absorption and utilization of iron. They can promote the absorption of non-heme iron in the intestine and improve the bioavailability of iron.

[0019] 3. Cows that have not come into estrus for 2 months postpartum can achieve a 100% estrus rate after using a feed additive that promotes estrus in cows.

[0020] 4. This application targets the digestive and absorption mechanism of cows, and encapsulates yeast iron and vitamin E with palm oil respectively, so that the feed additive can avoid being digested in the rumen of cows and can be absorbed in the small intestine, thereby further improving the effect of the feed additive. Detailed Implementation

[0021] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present application, and not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present application.

[0022] According to an embodiment of the present invention, a feed additive for cows that replenishes qi and promotes estrus is provided. By weight, it comprises 50-100 parts of Eucommia ulmoides leaf extract, 20-50 parts of Angelica sinensis extract, 20-50 parts of Ligusticum chuanxiong extract, 20-50 parts of Astragalus membranaceus extract, 30-50 parts of Glycyrrhiza uralensis extract, 20-40 parts of soy isoflavones, 30-60 parts of yeast iron, 20-50 parts of vitamin E, and 640-690 parts of bentonite. The yeast iron is coated with palm oil, and the vitamin E is also coated with palm oil. This formulation combines traditional Chinese medicine with soy isoflavones and yeast iron, which can improve the release of the medicinal effects of the traditional Chinese medicine and the body's absorption capacity, enhancing the effect of replenishing qi and blood. By replenishing qi and blood, it achieves the purpose of promoting estrus, and the effect is relatively rapid.

[0023] Eucommia ulmoides leaf extract contains eucommia flavonoids, which have phytoestrogen-like effects. After binding to estrogen receptors, they stimulate the hypothalamus-pituitary-gonadal axis in animals, exerting a regulatory effect. Eucommia flavonoids bind to estrogen receptors, stimulating the hypothalamus to release gonadotropin-releasing hormone. This hormone acts on the pituitary gland, which then produces follicle-stimulating hormone and luteinizing hormone, which in turn act on the ovaries, promoting follicle development and maturation. It can also reduce follicular atresia and decrease cell apoptosis.

[0024] Angelica sinensis extract contains ligustilide, butylidene lactone, ferulic acid, nicotinic acid, sucrose, various amino acids, and sesquiterpenoids. It has the effects of nourishing blood and regulating menstruation, promoting blood circulation and relieving pain, moistening the intestines and promoting bowel movements, and improving reproductive health.

[0025] Ligusticum chuanxiong extract: contains ligustilide, 3-butyrolactone and sapinene, and has the effects of promoting blood circulation, dispelling wind and relieving pain, and relieving depression and drying dampness.

[0026] Astragalus extract: mainly contains astragalus polysaccharides, astragalus extract, etc., which have the effects of nourishing blood and qi, strengthening the body and stopping sweating. It can be used as an adjunct treatment for symptoms such as qi and blood deficiency, spontaneous sweating due to superficial deficiency, weakness of limbs, mental fatigue, weakness due to prolonged illness, and weakness of spleen and stomach.

[0027] Licorice extract contains glycyrrhizin, glycyrrhizic acid, glycyrrhizin, glycyrrhizin flavonoids, gentianin, gentianin, quercetin, etc. It has the effects of tonifying the spleen and replenishing qi, relieving spasms and pain, and harmonizing the effects of other herbs.

[0028] The extract obtained through this method is concentrated to increase the content of active ingredients and make its effects more significant.

[0029] This invention is primarily aimed at cows; cows are ruminants, and the digestive and absorption mechanisms of ruminants differ from those of ordinary monogastric animals (such as sows), so the mechanisms by which the product works are also different.

[0030] Example 1

[0031] A feed additive for cows to replenish qi and promote estrus includes 100g of Eucommia ulmoides leaf extract, 40g of Angelica sinensis extract, 30g of Ligusticum chuanxiong extract, 40g of Astragalus membranaceus extract, 30g of Glycyrrhiza uralensis extract, 40g of soybean isoflavones, 50g of yeast iron coated with palm oil, 30g of vitamin E coated with palm oil, and 640g of bentonite. Preparation method:

[0032] (1) Material selection: Prepare materials according to the components in the formula;

[0033] (2) Sieving: Pass all raw materials through a 60-mesh sieve for later use;

[0034] (3) Mixing: Mix in a three-dimensional mixer for 15 minutes to ensure uniform mixing;

[0035] (4) Packaging: Pack the mixed raw materials into 100g / bag packages.

[0036] Example 2

[0037] A feed additive for cows to replenish qi and promote estrus includes 50g of Eucommia ulmoides leaf extract, 50g of Angelica sinensis extract, 20g of Ligusticum chuanxiong extract, 20g of Astragalus membranaceus extract, 50g of Glycyrrhiza uralensis extract, 20g of soybean isoflavones, 60g of yeast iron coated with palm oil, 50g of vitamin E coated with palm oil, and 680g of bentonite.

[0038] Preparation method:

[0039] (1) Material selection: Prepare materials according to the components in the formula;

[0040] (2) Sieving: Pass all raw materials through a 60-mesh sieve for later use;

[0041] (3) Mixing: Mix in a three-dimensional mixer for 15 minutes to ensure uniform mixing;

[0042] (4) Packaging: Pack the mixed raw materials into 100g / bag packages.

[0043] Example 3

[0044] A feed additive for cows to replenish qi and promote estrus includes 80g of Eucommia ulmoides leaf extract, 20g of Angelica sinensis extract, 50g of Ligusticum chuanxiong extract, 50g of Astragalus membranaceus extract, 30g of Glycyrrhiza uralensis extract, 30g of soybean isoflavones, 30g of yeast iron coated with palm oil, 20g of vitamin E coated with palm oil, and 690g of bentonite.

[0045] Preparation method:

[0046] (1) Material selection: Prepare materials according to the components in the formula;

[0047] (2) Sieving: Pass all raw materials through a 60-mesh sieve for later use;

[0048] (3) Mixing: Mix in a three-dimensional mixer for 15 minutes to ensure uniform mixing;

[0049] (4) Packaging: Pack the mixed raw materials into 100g / bag packages.

[0050] Comparative Example 1

[0051] A feed additive for cows to replenish qi and promote estrus includes 100g of Eucommia ulmoides leaf extract, 40g of Angelica sinensis extract, 30g of Ligusticum chuanxiong extract, 40g of Astragalus membranaceus extract, 30g of Glycyrrhiza uralensis extract, and 760g of bentonite. Preparation method:

[0052] (1) Material selection: Prepare materials according to the components in the formula;

[0053] (2) Sieving: Pass all raw materials through a 60-mesh sieve for later use;

[0054] (3) Mixing: Mix in a three-dimensional mixer for 15 minutes to ensure uniform mixing;

[0055] (4) Packaging: Pack the mixed raw materials into 100g / bag packages.

[0056] Comparative Example 2

[0057] A feed additive for cows to replenish qi and promote estrus includes 100g of Eucommia ulmoides leaf extract, 40g of Angelica sinensis extract, 30g of Ligusticum chuanxiong extract, 40g of Astragalus membranaceus extract, 30g of Glycyrrhiza uralensis extract, 40g of soybean isoflavones, 10g of yeast iron coated with palm oil, 30g of vitamin E coated with palm oil, and 680g of bentonite.

[0058] Comparative Example 3

[0059] A feed additive for cows to replenish qi and promote estrus includes 100g of Eucommia ulmoides leaf extract, 40g of Angelica sinensis extract, 30g of Ligusticum chuanxiong extract, 40g of Astragalus membranaceus extract, 30g of Glycyrrhiza uralensis extract, 20g of soybean isoflavones without palm oil coating, 30g of yeast iron without palm oil coating, 30g of vitamin E, and 680g of bentonite.

[0060] Preparation method:

[0061] (1) Material selection: Prepare materials according to the components in the formula;

[0062] (2) Sieving: Pass all raw materials through a 60-mesh sieve for later use;

[0063] (3) Mixing: Mix in a three-dimensional mixer for 15 minutes to ensure uniform mixing;

[0064] (4) Packaging: Pack the mixed raw materials into 100g / bag packages.

[0065] Animal Experiment 1

[0066] A trial was conducted at a beef cattle farm in Nong'an County, Changchun City, Jilin Province, involving 150 cows, all of whom were postpartum cows that had not yet returned to estrus for two months. The cows were randomly divided into five groups of 30 each. All cows were fed the same weight of beef cattle concentrate supplement. The first group received an additional dose of the product from Example 1, the second group received an additional dose of the product from Comparative Example 1, the third group received an additional dose of the product from Comparative Example 2, and the fourth group received an additional dose of the product from Comparative Example 3. Each cow received 50g of the product twice daily. The control group received no additional supplementation. The trial lasted 21 days, and the results are shown in Table 1 below.

[0067] Table 1. Estrus rate results after product use in Examples 1 and Comparative Examples 1-3.

[0068] Example quantity Number of estrus cycles after use estrus rate Group 1 30 29 96.67％ Group 2 30 20 66.67％ Group 3 30 23 76.67％ Group 4 30 24 80％ Blank control group 30 6 20％

[0069] The results showed that the product of Example 1 had the best effect, with an estrus rate of 96.67%. Comparative Example 1, lacking the addition of soy isoflavones, yeast iron, and vitamin E, contained only traditional Chinese medicine ingredients, resulting in a slower onset of action and a more limited effect, thus its estrus rate was lower than that of Example 1. In Comparative Example 2, although soy isoflavones and yeast iron were added, the yeast iron content was low, and the ratio of the two was unreasonable, leading to a lower estrus rate. In Comparative Example 3, the yeast iron and vitamin E were not coated, and some of their components were already digested in the rumen, thus causing a decrease in the estrus rate compared to Example 1.

[0070] Animal Experiment 2: A trial of Examples 1-3 was conducted at a cattle farm in Zhujiafang Village, Liaozhong District, Shenyang City, Liaoning Province. A total of 45 cows, all of whom were postpartum cows that had not yet returned to estrus for two months, were used. They were randomly divided into three groups of 15 cows each. All cows were fed the same weight of beef concentrate supplement. Group 1 received an additional dose of the product from Example 1, Group 2 received an additional dose of the product from Example 2, and Group 3 received an additional dose of the product from Example 3. Each cow received 50g twice daily for 15 days. The results are as follows:

[0071] Table 2 shows the estrus rate results after using the products in Examples 1-3.

[0072] Example quantity Number of estrus cycles after use estrus rate Group 1 15 15 100％ Group 2 15 13 86.67％ Group 3 15 12 80％

[0073] The results showed that the optimal formulation was Example 1, with an estrus rate of 100%. Example 2, due to its lower content of soy isoflavones and Eucommia ulmoides leaf extract, while effective, was not as effective as Example 1. Example 3, with significantly reduced content of soy isoflavones, yeast iron, and vitamin E, also had less desirable effects than Examples 1 and 2. Comparative Example 1, a pure traditional Chinese medicine formula, showed a significantly lower estrus rate compared to the examples. This is because the release of the medicinal effects of the traditional Chinese medicine is further enhanced by soy isoflavones and yeast iron; their combined effect is faster. In Comparative Example 2, the dosage of yeast iron and soy isoflavones also affected the estrus rate; when their dosages were outside the protected range, the estrus effect did not reach the level of this formulation.

[0074] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A feed additive for cows that replenishes qi and promotes estrus, characterized in that, The product, by weight, comprises 50-100 parts of Eucommia ulmoides leaf extract, 20-50 parts of Angelica sinensis extract, 20-50 parts of Ligusticum chuanxiong extract, 20-50 parts of Astragalus membranaceus extract, 30-50 parts of Glycyrrhiza uralensis extract, 20-40 parts of soy isoflavones, 30-60 parts of yeast iron, 20-50 parts of vitamin E, and 640-690 parts of bentonite. The yeast iron is yeast iron coated with palm oil, and the vitamin E is vitamin E coated with palm oil. By weight, the ratio of soy isoflavones to yeast iron is 2-5:

5.

2. The feed additive for inducing estrus in cows according to claim 1, characterized in that, The ratio of soy isoflavones to yeast iron by weight is 4:

5.

3. The feed additive for inducing estrus in cows according to claim 1, characterized in that, The ratio of the total amount of Eucommia ulmoides leaf extract, Angelica sinensis extract, Ligusticum chuanxiong extract, Astragalus membranaceus extract, and Glycyrrhiza uralensis extract to the amount of yeast iron, by mass fraction, is 4-6:

1.

4. The feed additive for inducing estrus in cows according to claim 1, characterized in that, By weight, it consists of 100 parts of Eucommia ulmoides leaf extract, 40 parts of Angelica sinensis extract, 30 parts of Ligusticum chuanxiong extract, 40 parts of Astragalus membranaceus extract, 30 parts of Glycyrrhiza uralensis extract, 40 parts of soy isoflavones, 50 parts of yeast iron, 30 parts of vitamin E, and 640 parts of bentonite.

5. The feed additive for inducing estrus in cows according to claim 1, characterized in that, By weight, it consists of 50 parts of Eucommia ulmoides leaf extract, 50 parts of Angelica sinensis extract, 20 parts of Ligusticum chuanxiong extract, 20 parts of Astragalus membranaceus extract, 50 parts of Glycyrrhiza uralensis extract, 20 parts of soybean isoflavones, 60 parts of yeast iron, 50 parts of vitamin E, and 680 parts of bentonite.

6. The feed additive for inducing estrus in cows according to claim 1, characterized in that, By weight, it consists of 80 parts of Eucommia ulmoides leaf extract, 20 parts of Angelica sinensis extract, 50 parts of Ligusticum chuanxiong extract, 50 parts of Astragalus membranaceus extract, 30 parts of Glycyrrhiza uralensis extract, 30 parts of soybean isoflavones, 30 parts of yeast iron, 20 parts of vitamin E, and 690 parts of bentonite.

7. The feed additive for inducing estrus in cows according to claim 1, characterized in that, The preparation steps of the Eucommia ulmoides leaf extract are as follows: Eucommia ulmoides leaves are decocted in water for 150-200 minutes and then filtered and spray-dried to obtain Eucommia ulmoides leaf extract. The preparation steps of the Angelica sinensis extract are as follows: Angelica sinensis is decocted in water for 90-120 minutes and then filtered and spray-dried to obtain the Angelica sinensis extract; The preparation steps of the Ligusticum striatum extract are as follows: Ligusticum striatum is decocted in water for 120-150 minutes and then filtered and spray-dried to obtain the Ligusticum striatum extract. The preparation steps of the Astragalus extract are as follows: Astragalus is decocted in water for 120-150 minutes and then filtered and spray-dried to obtain the Astragalus extract; The preparation steps of the licorice extract are as follows: licorice is decocted in water for 120-150 minutes, then filtered and spray-dried to obtain the licorice extract.

8. A method for preparing a feed additive for cows to replenish qi and promote estrus as described in any one of claims 1-7, characterized in that, The preparation method is as follows: Eucommia ulmoides leaf extract, Angelica sinensis extract, Ligusticum chuanxiong extract, Astragalus membranaceus extract, Glycyrrhiza uralensis extract, soy isoflavones, yeast iron, vitamin E, and bentonite are mixed in a three-dimensional mixer for 10-15 minutes.

9. The method for preparing the feed additive for inducing estrus in cows according to claim 8, characterized in that, Eucommia ulmoides leaf extract, Angelica sinensis extract, Ligusticum chuanxiong extract, Astragalus membranaceus extract, Glycyrrhiza uralensis extract, soy isoflavones, yeast iron, vitamin E, and bentonite were each sieved through a 60-mesh sieve before mixing.