Dental anti-stain compositions, kits and methods of use thereof

Abstract

The present disclosure relates to a dental stain-resistant composition comprising a polyamine ester and dicalcium phosphate, and optionally other orally acceptable carriers and / or excipients. The present disclosure also provides a dental stain-resistant kit, and a method of dental stain resistance using the dental stain-resistant composition.

Description

Technical Field

[0001] This disclosure relates to tooth staining compositions and combinations comprising such tooth staining compositions, kits, and methods of using them. Background Technology

[0002] In modern times, more and more people are paying attention to the aesthetics of their teeth, and bright, white teeth are something everyone dreams of. Teeth whitening is one of the quickest and most effective methods. There are many reasons for tooth discoloration, mainly divided into "physiological" and "pathological" causes.

[0003] The "physiological" cause of tooth discoloration is mainly due to age. As we age, teeth tend to become more yellowish. This yellowing can be exacerbated by dietary habits such as drinking tea, coffee, red wine, or habitually consuming curry, which can lead to food pigments depositing on the tooth surface. The "pathological" cause of tooth discoloration is commonly seen in cavities, teeth that have undergone root canal treatment, or teeth that have been traumatized.

[0004] Teeth whitening is the most effective way to remove stains deposited on teeth. Its effectiveness depends on the concentration of peroxide and the duration of contact with the teeth, and dietary habits during the treatment can affect the overall whitening result. Numerous academic studies have indicated that teeth whitening can cause surface damage, making it easier for stains to accumulate and increasing tooth sensitivity. In particular, drinking coffee, cola, or other pigmented beverages after whitening can make teeth more prone to staining. Therefore, there remains a need for products and methods that prolong the whitening effect and prevent stains from re-attaching to teeth after whitening to address these issues. Summary of the Invention

[0005] This disclosure provides a tooth stain-resistant composition comprising polyurethane and dicalcium phosphate, and optionally other oral-acceptable carriers and / or excipients.

[0006] This disclosure also provides a tooth staining kit comprising a tooth staining composition and instructions for using the tooth staining composition.

[0007] This disclosure also provides a method for resisting tooth staining, comprising applying a tooth-resistant composition to teeth, wherein the composition comprises polyurethane and dicalcium phosphate, and optionally other oral-acceptable carriers and / or excipients. Attached Figure Description

[0008] Figure 1 A tooth shade guide created with a camera, based on the VITA Bleachedguide 3D-MASTER.

[0009] Figure 2 The color gradation of anti-stain gel formulations containing different concentrations of polyurethane-35 is shown.

[0010] Figure 3 The color gradation of anti-staining gel formulations containing different concentrations of dicalcium phosphate is shown.

[0011] Figure 4 The color gradation of anti-staining gel formulations containing different concentrations of calcium lactate is shown.

[0012] Figures 5 to 9 The color gradation of anti-staining gel formulations containing different concentrations of polyurethane-35, dicalcium phosphate, and calcium lactate is shown.

[0013] Figure 10 The color gradation of the teeth whitening effect.

[0014] Figure 11 The color gradation of the anti-staining effect on teeth. Detailed Implementation

[0015] It should be understood that the present invention is not limited to the materials, structures, procedures, methods, or constructions of the specific examples listed herein. Therefore, although some options are listed herein, those similar or having the same effect can be applied to the implementation or embodiments of the present invention, and only preferred materials and methods are described herein.

[0016] It should also be understood that the terminology used herein is for the purpose of describing specific embodiments of the invention and is not intended to be limiting.

[0017] The detailed description below, in relation to the accompanying drawings, is intended to illustrate exemplary embodiments of the invention and not to represent the only exemplary embodiments in which the invention may be practiced. The term "exemplary" as used throughout this specification means "serving as an example, instance, or illustration" and should not necessarily be construed as preferred or superior to other exemplary embodiments. The detailed description includes specific details provided for the purpose of giving a comprehensive understanding of exemplary embodiments of the invention. It will be apparent to those skilled in the art that exemplary embodiments described herein may be practiced without these specific details.

[0018] definition:

[0019] As used herein, the following terms have the meanings as described in this paragraph.

[0020] Unless otherwise defined, all technical and scientific terms used herein generally have the same meaning as would be understood by one of ordinary skill in the art to which this invention pertains. In general, the nomenclature used herein is well-known and commonly used in the laboratory procedures of animal pharmacology, pharmaceutical science, separation science, and organic chemistry. It should be understood that the order of steps or the sequence of certain actions is irrelevant as long as it preserves the operability of this teaching. Furthermore, two or more steps or actions may be performed simultaneously or at different times.

[0021] As used herein, “a” and “a type” refer to one or more (i.e., at least one) objects. For example, “a component” refers to one or more components.

[0022] Unless otherwise specified, all percentages used herein are based on the total weight of the dental anti-staining composition. Unless otherwise specified, ratios used herein are weight ratios of corresponding components. Unless otherwise specified, all measurements were performed at 25°C.

[0023] As used herein, the term "teeth" refers to natural teeth or artificial dentition. As used herein, the term "tooth surface" refers to the surface of natural teeth or the hard surface of artificial dentition, including dentures, caps, crowns, plates, bridges, fillings, implants, and the like. In one embodiment, tooth surface refers to the surface of natural teeth.

[0024] As used herein, the term "composition" refers to a mixture of at least one compound that can be used in this invention with an orally acceptable carrier and / or excipient.

[0025] As used herein, the term "orally acceptable" means a substance, such as a carrier or excipient, that does not eliminate the biological activity or properties of the useful compounds of the present invention and is relatively non-toxic, i.e., that the substance can be administered to a subject without causing undesirable biological effects or interacting with any component contained in the composition in a harmful manner.

[0026] As used herein, "effective amount" means an amount of compound or composition provided that, to the reasonable judgment of a person skilled in the art, is sufficient to induce a positive and beneficial effect, preferably a beneficial effect on oral health, but low enough to avoid unacceptable side effects, i.e., to provide a reasonable benefit for the risk ratio.

[0027] As used herein, the term "synergistic effect" refers to the effect produced by two or more ingredients that is greater than the simple sum of the effects of applying each ingredient individually, such as in prolonging the anti-staining effect on teeth.

[0028] Scope: Throughout this disclosure, various aspects of the invention may be presented in the form of scope. It should be understood that the scope description is for convenience and brevity only and should not be construed as limiting the scope of the invention. Therefore, the scope description should be considered as specifically disclosing all possible sub-scopes and single numerical values ​​within that scope. For example, a scope description from 1 to 6 should be considered as specifically disclosing sub-scopes such as from 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, 3 to 6, etc., and single and partial numbers within that scope, such as 1, 2, 2.7, 3, 4, 5, 5.3, and 6. This applies regardless of the width of the scope.

[0029] Tooth stain-resistant composition

[0030] The "dental anti-stain composition" used in this invention relates to a composition for use in oral care, oral hygiene, or oral aesthetics. The dental anti-stain composition of this invention comprises polyurethane and dicalcium phosphate, and optionally other oral-acceptable carriers and / or excipients.

[0031] The tooth stain-resistant composition of this disclosure may contain an orally acceptable amount of polyurethane. In one embodiment, the tooth stain-resistant composition may contain about 30% to about 3% polyurethane by weight of the total composition, preferably about 30% to about 10% polyurethane, more preferably about 30% to about 20% polyurethane. In another embodiment, the polyurethane content in the tooth stain-resistant composition of this disclosure may be 30%, 29%, 28%, 27%, 26%, 25%, 24%, 23%, 22%, 21%, 20%, 19%, 18%, 17%, 16%, 15%, 14%, 13%, 12%, 11%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, or 3% of the total composition, or any content between the foregoing.

[0032] The tooth stain-resistant composition of this disclosure may contain an orally acceptable amount of dicalcium phosphate. In one embodiment, the tooth stain-resistant composition may contain about 25% to about 0.1% of dicalcium phosphate by weight of the total composition, preferably about 10% to about 0.5% of dicalcium phosphate, more preferably about 5% to about 1% of dicalcium phosphate, and most preferably about 3% to about 1% of dicalcium phosphate. In another embodiment, the content of dicalcium phosphate in the tooth stain-resistant composition of this disclosure may be 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2.8%, 2.6%, 2.4%, 2.2%, 2.0%, 1.8%, 1.6%, 1.4%, 1.2%, 1.0%, 0.9%, 0.8%, 0.7%, 0.6%, 0.5%, 0.4%, 0.3%, 0.2%, or 0.1% of the total weight of the composition, or any content between the above.

[0033] The dental anti-staining composition of this disclosure may contain an orally acceptable amount of calcium lactate. In one embodiment, the dental anti-staining composition may contain about 25% to about 0.1% calcium lactate by weight of the total composition, preferably about 10% to about 0.1% calcium lactate, more preferably about 5% to about 0.5% calcium lactate, and most preferably about 3% to about 0.5% calcium lactate. In another embodiment, the calcium lactate content in the dental anti-staining composition of this disclosure may be 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1.8%, 1.6%, 1.4%, 1.2%, 1.0%, 0.9%, 0.8%, 0.7%, 0.6%, 0.5%, 0.4%, 0.3%, 0.2%, or 0.1% of the total weight of the composition, or any content between the foregoing.

[0034] The dental anti-staining composition of this disclosure may contain at least one cross-linked polyvinylpyrrolidone (PVP) thickener. The cross-linked PPVP may include homopolymers of PPVP or N-vinyl-2-pyrrolidone. In one embodiment, the dental anti-staining composition may contain about 30% to about 2.5% PPVP by weight of the composition, preferably about 15% to about 10%.

[0035] The dental anti-staining compositions of this disclosure may comprise polyphosphate materials known to effectively reduce the deposition of calcium phosphate minerals associated with tartar formation as anti-tartar agents, such as synthetic anionic polymers, copolymers of polyacrylates, maleic anhydride and / or methyl vinyl ethers, and mixtures thereof, preferably acrylate copolymers. In one embodiment, the content of the acrylate copolymer in the dental anti-staining composition may be from about 20% to about 0.2% by weight of the composition, preferably from about 2.5% to about 1.5%.

[0036] The dental anti-staining composition of this disclosure may contain titanium dioxide. In one embodiment, the content of titanium dioxide in the dental anti-staining composition may be from about 25% to about 0.1% by weight of the composition, preferably from about 5% to about 0.25%, more preferably from about 1.5% to about 0.5%.

[0037] Teeth whitening composition

[0038] This disclosure provides a teeth whitening composition comprising hydrogen peroxide and an orally acceptable carrier, wherein the teeth whitening composition may contain about 0.1% to about 6% hydrogen peroxide by weight of the total composition, preferably about 2% to about 6%, and more preferably 4% to about 6%.

[0039] In one embodiment, the teeth whitening composition of this disclosure further comprises a group selected from water, glycerin, propylene glycol, potassium citrate, polyvinylpyrrolidone, acrylates, alkyl acrylate crosspolymers, potassium nitrate, ethyl mentholatum formamide, pearl extract, and other orally acceptable ingredients.

[0040] Carriers and excipients

[0041] In this document, "orally acceptable carrier" and / or "orally acceptable excipient" are used interchangeably and refer to any carrier and / or excipient useful in the tooth staining compositions of this disclosure. Such an orally acceptable carrier and / or excipient, at the amounts disclosed herein, when retained in the oral cavity without being swallowed for a period of time as required by the present invention, is sufficient to make effective contact with the tooth surface without causing harm to mammals. Generally, such orally acceptable carrier and / or excipient is also harmless if accidentally swallowed.

[0042] As used in this disclosure, orally acceptable carriers and / or excipients refer to any safe and effective material that can be used in the tooth staining compositions of embodiments or examples of this disclosure without altering the efficacy or properties of the aforementioned key components. Suitable orally acceptable carriers and / or excipients that can be used in the tooth staining compositions of this disclosure may include one or more of the following groups: water, humectants, surfactants, sensitizing agents, antibacterial agents or preservatives, flavoring agents, etc.

[0043] The tooth stain-resistant composition of this disclosure may contain at least one humectant selected from the group consisting of sorbitol, glycerin, xylitol, propylene glycol, or combinations thereof.

[0044] The tooth stain-resistant composition of this disclosure may contain at least one surfactant, which may be anionic, nonionic, amphoteric, zwitterionic, cationic, or a mixture thereof. The surfactant is preferably selected from the group consisting of polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, or combinations thereof.

[0045] The tooth stain-resistant composition of this disclosure may contain at least one potassium salt as an antisensitizing agent, wherein the potassium salt is selected from the group consisting of potassium citrate, potassium nitrate, potassium chloride, or combinations thereof.

[0046] The tooth stain-resistant composition of this disclosure may contain at least one antimicrobial agent or preservative, wherein the antimicrobial agent or preservative is selected from the group consisting of phenoxyethanol, benzoic acid, salicylic acid, p-hydroxybenzoic acid, methylparaben, chlorphenesin, ethylhexylglycerin, or combinations thereof.

[0047] The tooth stain-resistant composition of this disclosure may comprise at least one flavoring agent, wherein the flavoring agent comprises essential oils and various flavoring aldehydes, esters, and alcohols, wherein examples of the essential oils include oil extracts of lemon, lime, grapefruit, orange, peppermint, wintergreen, sassafras, clove, sage, spearmint, marjoram, and cinnamon. In one embodiment, the flavoring agent comprises acesulfame potassium, ethylmenthaneformamide, menthol, carvone, or anethole.

[0048] The tooth stain-resistant composition of this disclosure may contain at least one abrasive, wherein the abrasive is selected from the group consisting of aluminum hydroxide, aluminum silicate, dicalcium phosphate, silica, calcium carbonate, bentonite, or combinations thereof.

[0049] It will be readily apparent to those skilled in the art that some components contained in the tooth stain-resistant compositions of this disclosure may have multiple functions. Therefore, the statement herein that a compound has one function does not preclude its use for other functions. For example, a compound such as menthol may function as both a flavoring agent and a disinfectant; a compound such as polysorbate 20 may function as both a surfactant and an emulsifier.

[0050] Dosage form

[0051] The tooth stain-resistant composition of this disclosure is designed to remain in the oral cavity for a sufficient period of time to substantially contact the entire tooth surface to achieve stain-resistant activity. Therefore, the tooth stain-resistant composition of this disclosure can be in the form of a solution, slurry, gel, paste, ointment, or any other dosage form. In one embodiment, the tooth stain-resistant composition is a mouthwash. In another embodiment, the tooth stain-resistant composition is a topical gel. In yet another embodiment, the tooth stain-resistant composition is a toothpaste.

[0052] The teeth whitening composition of this disclosure remains in the oral cavity for a sufficient period of time to substantially contact the entire tooth surface to achieve a whitening effect. Therefore, the teeth whitening composition of this disclosure can be in the form of a solution, paste, gel, ointment, or any other dosage form. In one embodiment, the teeth whitening composition is a mouthwash. In another embodiment, the teeth whitening composition is a topical gel. In yet another embodiment, the teeth whitening composition is a toothpaste.

[0053] Uses and methods

[0054] When implementing the tooth stain-resistant composition of this disclosure, the user only needs to apply the tooth stain-resistant composition to the surface of human teeth to obtain the desired effect in the desired tooth area, such as stain resistance, teeth whitening, and fresh breath. The tooth stain-resistant composition of this disclosure can be safely applied to other oral surfaces besides teeth, such as oral mucosa or gums, without causing or inducing allergies or discomfort. The tooth stain-resistant composition of this disclosure can be applied to teeth by any means, preferably using a toothbrush or dental brace or direct rinsing.

[0055] In one embodiment, when the tooth staining composition of this disclosure is in the form of a gel, paste, or ointment, an effective amount of the tooth staining composition can be applied to the tooth surface using a toothbrush. After the tooth surface is in contact with the tooth staining composition for a period of time, the tooth surface is then rinsed clean by rinsing. In another embodiment, when the tooth staining composition of this disclosure is in the form of a gel, paste, or ointment, an effective amount of the tooth staining composition can be filled into a dental crown, which is then placed over the teeth. After the tooth surface is in contact with the staining composition in the dental crown for a period of time, the tooth surface is then rinsed clean by rinsing. The contact time between the tooth staining composition and the tooth surface can vary depending on the concentration of the active ingredient in the tooth staining composition, for example, within 30 minutes, preferably 30 seconds to 25 minutes, more preferably 30 seconds to 10 minutes, and most preferably 30 seconds to 3 minutes.

[0056] In one embodiment, when the tooth staining composition of this disclosure is in the form of a solution or slurry, such as a mouthwash, an effective amount of the tooth staining composition can be applied directly, left in the mouth for a period of time, and then the tooth surface can be rinsed clean by rinsing.

[0057] There are no restrictions on the timing of application of the tooth stain-resistant composition of this disclosure. For example, it can be applied after daily cleaning with a dental cleaning agent. Preferably, it can be applied after a dental cleaning or teeth whitening procedure performed by a dentist. Alternatively, it can be applied at home after teeth whitening with a teeth whitening agent. There are no particular restrictions on the number or frequency of applications of the tooth stain-resistant composition of this disclosure within oral-acceptable limits. Preferably, it can be applied immediately after daily dental cleaning, preferably three times a day, twice a day, once a day, once every two days, once every three days, once every four days, once every five days, once every six days, or once a week. Alternatively, it can be used as directed by a dentist.

[0058] Reagent test kit

[0059] This disclosure provides a tooth staining kit comprising the above-described tooth staining composition and instructions for use, which the user may refer to when applying the tooth staining composition.

[0060] This disclosure also provides a teeth whitening and anti-staining kit, which includes the above-mentioned anti-staining composition, teeth whitening composition and instructions for use. Users can refer to the instructions for use to first apply the teeth whitening composition for the teeth whitening step, and then apply the teeth anti-staining composition for the teeth anti-staining step.

[0061] The following embodiments further illustrate preferred embodiments of the present disclosure, but it should be understood that the present disclosure is not limited to the contents of the embodiments described below.

[0062] Example

[0063] Materials and Methods

[0064] A. Selection criteria for test teeth

[0065] The teeth used in this embodiment are human permanent teeth, which are permanent teeth extracted from adults over 20 years of age for orthodontic treatment or abnormal tooth position. The selection criteria are set as follows: the surface has not been filled, the crown and root may be partially or completely cracked, and there is no lesion at the root apex. However, teeth with enamel hypoplasia, deformed or broken teeth, teeth with lesions at the root apex, congenital tooth discoloration, and tooth staining caused by smoking or chewing betel nut for more than one year are excluded.

[0066] B. Preparation of anti-dyeing agents

[0067] Anti-dyeing agent formulations in gel form containing different concentrations of polyurethane, dicalcium phosphate, and calcium lactate were prepared. Detailed components are shown in Table 1A. Except for the content of polyurethane, dicalcium phosphate, and calcium lactate, all other components and their contents are the same in each formulation. X represents the weight change of polyurethane-35 in the examples. Y represents the weight change of dicalcium phosphate in the examples. Z represents the weight change of calcium lactate in the examples.

[0068] Table 1A Composition of Anti-dyeing Agent

[0069]

[0070] C. Preparation of whitening agents

[0071] A whitening agent formulation containing 5.6% hydrogen peroxide in gel form was prepared. The detailed ingredients are shown in Table 1B.

[0072] Table 1B: Ingredients of Whitening Agents

[0073]

[0074] D. Staining solution

[0075] The following examples used commercially available Nespresso espresso to prepare the staining solution at a temperature of 37±2.5°C. In other examples, the staining resistance tests were conducted using staining solutions of the same concentration and composition prepared with the same espresso espresso.

[0076] E. Preparation of Tooth Shading Cards

[0077] Based on the 29 shades of whitening published by the American Dental Association (ADA) as the color matching benchmark, and using the VITA Bleachedguide 3D-MASTER as the reference standard, a tooth color matching card was created using a camera (Canon M6 Mark II). Figure 1 As shown in the figure, it is used to compare the results of changes in tooth color gradation.

[0078] Example 1

[0079] The collected teeth were randomly selected and cleaned with 37% phosphoric acid, then rinsed with water to remove surface dirt, and then dried in a 37°C oven.

[0080] Anti-staining gel formulations A (as shown in Table 1A) containing different concentrations of polyurethane-35 were prepared, as shown in Table 2. Formulations A-1, A-2, and A-3 contained 3%, 15%, and 30% polyurethane-35 by weight of the total anti-staining gel, respectively, with all other components remaining the same, as shown in Table 1A. Teeth were immersed in the above anti-staining gel formulations for 15 minutes, then rinsed once with water and dried. This process was repeated 7 times. Teeth were then immersed in the staining solution for 6 hours, and photographed every 15 minutes under the same conditions as those used in preparing the tooth color chart.

[0081] Table 2

[0082] Element Formula A-1 Formula A-2 Formula A-3 X 3％ 15％ 30％

[0083] The control group used water instead of anti-staining gel formulation A and performed the same steps as described above.

[0084] The results are as follows Figure 2 As shown in the figure, the average shade of the teeth in the control group before immersion in the staining solution was 7.6. After one hour, it increased to 28.33, a shade change of 97.7%. After two hours of continuous immersion, it reached 29 shades, a shade change of 100%.

[0085] In the experimental groups, the teeth in anti-staining gel formulation A-1, containing 3% polyurethane-35, had an average tooth color level of 2 before immersion in the staining solution. After two hours of immersion, the color level improved to 17.43, a change of 60.11%. After six hours of continuous immersion, the color level was measured at 25.53, a change of 88.04%. The teeth in anti-staining gel formulation A-2, containing 15% polyurethane-35, had a tooth color level of 3 before immersion in the staining solution. After two hours of immersion, the color level improved to 15.5, a change of 53.44%. After six hours of continuous immersion, the color level was 25, a change of 86.2%. The teeth in anti-staining gel formulation A-3, containing 30% polyurethane-35, had a tooth color level of 1 before immersion in the staining solution. After two hours of immersion, the color level improved to 12.25, a change of 42.24%. After six hours of continuous immersion, the color level was 18, a change of 62.06%.

[0086] The results show that in the control group not treated with the anti-staining gel of this disclosure, the teeth showed weak resistance to coffee pigment staining, with a color change of 97.7% after one hour of coffee immersion. Treatment with the anti-staining gel formulations A-1, A-2, and A-3 of this disclosure effectively improved the teeth's resistance to staining in a long-term coffee environment compared to the control group.

[0087] Example 2

[0088] Anti-staining gel formulations B (as shown in Table 1A) containing different concentrations of dicalcium phosphate were prepared, namely, formulations B-1, B-2, and B-3, which contain 0%, 1%, and 2% dicalcium phosphate by weight of the total anti-staining gel, respectively, with all other components remaining the same, as shown in Table 1A. Teeth were immersed in the above anti-staining gel formulations for 15 minutes, then rinsed once with water and dried. This process was repeated 7 times. Teeth were then immersed in coffee for 6 hours, and photographed every 15 minutes under the same conditions as those used to prepare the tooth color chart.

[0089] Table 3

[0090] Element Formula B-1 Formula B-2 Formula B-3 Y 0％ 1％ 2％

[0091] The control group used water instead of anti-staining gel formulation B and performed the same steps as described above.

[0092] The results are as follows Figure 3As shown. The average tooth shade of the anti-staining gel formulation B-1 (without dicalcium phosphate) before immersion in the staining solution was level 2. After one hour of immersion, it improved to level 14.8 (shade change 51.03%), after two hours of immersion, it improved to level 18.3 (shade change 53.44%), and after six consecutive hours of immersion, it reached level 25.7 (shade change 88.62%). The tooth shade of the anti-staining gel formulation B-2 (containing 1% dicalcium phosphate) before immersion in the staining solution was level 3. After two hours of immersion, it improved to level 15.5 (shade change 53.44%), and after six consecutive hours of immersion, it reached level 25 (shade change 86.2%). The tooth shade of the anti-staining gel formulation B-3 (containing 2% dicalcium phosphate) before immersion in the staining solution was level 1.5. After two hours of immersion, it improved to level 14.85 (shade change 51.12%), and after six consecutive hours of immersion, it reached level 17.22 (shade change 59.39%).

[0093] As described in Example 1, in the control group not treated with the anti-staining gel of this disclosure, the color gradation change reached 97.7% after one hour of coffee infusion. These results show that, compared to the control group, teeth treated with both anti-staining gel formulations containing and without dicalcium phosphate exhibited superior anti-staining effects. Notably, the anti-staining gel formulation with added dicalcium phosphate is more effective in enhancing the stain resistance of teeth exposed to coffee over extended periods compared to the formulation without dicalcium phosphate. It also demonstrates better anti-staining effects compared to other concentrations.

[0094] Example 3

[0095] Anti-staining gel formulations C (as shown in Table 1A) containing different concentrations of calcium lactate were prepared, namely, formulations C-1, C-2, and C-3, which contain 0%, 0.5%, and 1% calcium lactate by weight of the total anti-staining gel, respectively, with all other components remaining the same, as shown in Table 1A. Teeth were immersed in the above anti-staining gel formulations for 15 minutes, then rinsed once with water and dried. This process was repeated 7 times. Teeth were then immersed in coffee for 6 hours, and photographed every 15 minutes under the same conditions as those used to prepare the tooth color chart.

[0096] Table 4

[0097] Element Formula C-1 Formula C-2 Formula C-3 Z 0％ 0.5％ 1％

[0098] The control group used water instead of anti-staining gel formulation C and performed the same steps as described above.

[0099] The results are as follows Figure 5As shown. The teeth in the anti-staining gel formulation C-1 (without calcium lactate) had an average shade of 3 before immersion in the staining solution. After one hour of immersion, the shade improved to 13.5 (45.5% change), after two hours to 15.5 (53.44% change), and after six hours of continuous immersion, the shade reached 25 (86.2% change). The teeth in the anti-staining gel formulation C-2 (containing 0.5% calcium lactate) had a shade of 1 before immersion in the staining solution. After two hours of immersion, the shade improved to 15.2 (52.41% change), and after six hours of continuous immersion, the shade reached 24.63 (84.94% change). The teeth in the anti-staining gel formulation C-3 (containing 1% calcium lactate) had a shade of 1 before immersion in the staining solution. After two hours of immersion, the shade improved to 15.06 (51.95% change), and after six hours of continuous immersion, the shade reached 23.3 (80.34% change).

[0100] As described in Example 1, in the control group not treated with the anti-staining gel of this disclosure, the color gradation change reached 97.7% after one hour of coffee infusion. These results show that, compared to the control group, teeth treated with both calcium lactate-free and calcium lactate-containing anti-staining gel formulations exhibited better anti-staining effects. Notably, the anti-staining gel formulation with added calcium lactate is more effective than the formulation without added calcium lactate in enhancing the teeth's resistance to staining in a long-term coffee environment.

[0101] Example 4

[0102] According to Table 5, anti-staining gel formulations D-1, D-2, and D-3 containing different concentrations of polyurethane-35, dicalcium phosphate, and calcium lactate were prepared, with all other components being the same, as shown in Table 1A.

[0103] Table 5

[0104] Element Formula D-1 Formula D-2 Formula D-3 X 3％ 30％ 30％ Y 0％ 2％ 2％ Z 0％ 0％ 1％

[0105] The results are as follows Figure 5As shown. The anti-stain gel formulation D-1, containing 3% polyurethane-35, 0% dicalcium phosphate, and 0% calcium lactate, had an average tooth shade of 1 before immersion in the staining solution. After one hour of immersion, the shade increased to 12.6, a change of 43.6%. After two hours of immersion, it increased to 15.6, a change of 54.02%. After six consecutive hours of immersion, the shade reached 18, a change of 62.06%. The anti-stain gel formulation D-2, containing 30% polyurethane-35, 2% dicalcium phosphate, and 0% calcium lactate, had an average tooth shade of 1 before immersion in the staining solution. After two hours of immersion, the shade increased to 11.6, a change of 40.11%. After six consecutive hours of immersion, the shade reached 15.1, a change of 52.06%. The anti-stain gel formulation D-3, containing 30% polyurethane-35, 2% dicalcium phosphate, and 1% calcium lactate, showed an average tooth color level of 1 before immersion in the staining solution. After immersion for two hours, the color level increased to 10.1, a change of 34.82%. After immersion for six consecutive hours, the color level was 13.1, a change of 45.1%.

[0106] The results show that the anti-staining gel formulation D-3, containing polyurethane-35, dicalcium phosphate, and calcium lactate, is more effective than the anti-staining gel formulation D-1, which contains polyurethane-35, and the anti-staining gel formulation D-2, which contains polyurethane-35 and dicalcium phosphate, in enhancing the resistance of teeth to staining in a long-term coffee environment.

[0107] Example 5

[0108] Based on the experiments described above, it is known that polyurethane-35, calcium hydrogen phosphate, and calcium lactate, at different concentrations, individually, and in combination, possess certain anti-staining properties. The following examples further explore the synergistic effect of the composition ratios and anti-staining properties of these three different raw materials.

[0109] According to Table 6, anti-staining gel formulations C-1, E, F and G containing different concentrations of polyurethane-35, dicalcium phosphate and calcium lactate were prepared, with the remaining components shown in Table 1A.

[0110] Table 6

[0111] Element Formula C-1 Formula E Formula F Formula G X 15％ 15％ 0％ 0％ Y 1％ 0％ 1％ 0％ Z 0％ 0％ 0％ 0.5％

[0112] First, the anti-staining effect was tested using anti-staining compositions containing polyurethane-35, dicalcium phosphate, or calcium lactate alone. The results are as follows: Figure 6-1 and 6-2 As shown. Synergistic effects of polyurethane-35 and dicalcium phosphate were tested, as shown in formulations C-1 and E in Table 6-3. Detailed anti-staining results are as follows. Figure 6-3 As shown.

[0113] Formula C-1, prepared as described in Example 3 above, contains 15% polyurethane-35, 1% dicalcium phosphate, and 0% calcium lactate. The average tooth shade without coffee immersion is level 3. After one hour, it increases to level 13.5, a 45.5% change in shade; after two hours, it increases to level 15.5, a 53.44% change in shade; and after six hours of continuous immersion, it reaches level 25, a 86.2% change in shade. Formula E, prepared in the same manner, contains 15% polyurethane-35, 0% dicalcium phosphate, and 0% calcium lactate. The average tooth shade without coffee immersion is level 1.76. After one hour, it increases to level 17.06, a 58.85% change in shade; after two hours, it increases to level 21.53, a 74.25% change in shade; and after six hours of continuous immersion, it reaches level 27.33, a 94.25% change in shade. The results show that the combination of polyurethane-35 and dicalcium phosphate extends the stain resistance of teeth longer than polyurethane-35 alone.

[0114] Example 6

[0115] Example 6 was conducted in a manner similar to Example 5 above. According to Table 7, anti-staining gel formulations B-1 and E, containing different concentrations of polyurethane-35, dicalcium phosphate, and calcium lactate, were prepared, with the remaining components shown in Table 1A. Detailed anti-staining results are as follows: Figure 7 As shown.

[0116] Table 7

[0117] Element Formula B-1 Formula E X 15％ 15％ Y 0％ 0％ Z 0.5％ 0％

[0118] Formula B-1, prepared as described in Example 3 above, contains 15% polyurethane-35, 0% dicalcium phosphate, and 0.5% calcium lactate. Without coffee immersion, the average tooth shade is level 2. After one hour, it increases to level 14.8 (51.03% change); after two hours, it increases to level 18.3 (53.44% change); and after six hours of continuous immersion, it reaches level 25.7 (88.62% change). Formula E, containing 15% polyurethane-35, 0% dicalcium phosphate, and 0% calcium lactate, has an average tooth shade of 1.76 without coffee immersion. After one hour, it increases to level 17.06 (58.85% change); after two hours, it increases to level 21.53 (74.25% change); and after six hours of continuous immersion, it reaches level 27.33 (94.25% change). The results show that the combination of polyurethane-35 and calcium lactate extends the stain resistance of teeth longer than polyurethane-35 alone.

[0119] Example 7

[0120] Example 7 was carried out in a manner similar to Example 5 above. According to Table 8, anti-staining gel formulations D-2 and D-3 were prepared containing different concentrations of polyurethane-35, dicalcium phosphate, and calcium lactate, with the remaining components shown in Table 1A. Detailed anti-staining results are as follows: Figure 8 As shown.

[0121] Table 8

[0122] Element Formula D-2 Formula D-3 X 30％ 30％ Y 2％ 2％ Z 0％ 1％

[0123] Formulas D-2 and D-3 were prepared as described in Example 4 above. Formula D-2 contains 30% polyurethane-35, 2% dicalcium phosphate, and 0% calcium lactate. The tooth color gradation without coffee immersion is level 1, which increases to level 11.6 after two hours, a color gradation change of 40.11%; after six hours of continuous immersion, the color gradation is level 15.1, a color gradation change of 52.06%. Formula D-3 contains 30% polyurethane-35, 2% dicalcium phosphate, and 1% calcium lactate. The tooth color gradation without coffee immersion is level 1, which increases to level 10.1 after two hours, a color gradation change of 34.82%; after six hours of continuous immersion, the color gradation is level 13.1, a color gradation change of 45.1%. These results show that the combination of polyurethane-35 and dicalcium phosphate with calcium lactate in the anti-staining agent extends the tooth's anti-staining ability longer than the combination of polyurethane-35 and dicalcium phosphate alone.

[0124] Example 8

[0125] Example 8 was carried out in a manner similar to Example 5 above. According to Table 9, anti-staining gel formulations B-1 and B-2 containing different concentrations of polyurethane-35, dicalcium phosphate, and calcium lactate were prepared, with the remaining components shown in Table 1A. Detailed anti-staining results are as follows: Figure 9 As shown.

[0126] Table 9

[0127] Element Formula B-1 Formula B-2 X 15％ 15％ Y 0％ 1％ Z 0.5％ 0.5％

[0128] Formulas B-1 and B-2 were prepared as described in Example 2 above. Formula B-1 contains 15% polyurethane-35, 0% dicalcium phosphate, and 0.5% calcium lactate. Without coffee immersion, the average tooth shade was level 2. After one hour, it increased to level 14.8, a shade change of 51.03%; after two hours, it increased to level 18.3, a shade change of 53.44%; and after six hours of continuous immersion, it reached level 25.7, a shade change of 88.62%. Formula B-2 contains 15% polyurethane-35, 1% dicalcium phosphate, and 0.5% calcium lactate. Without coffee immersion, the tooth shade was level 3. After two hours, it increased to level 15.5, a shade change of 53.44%; and after six hours of continuous immersion, it reached level 25, a shade change of 86.2%. The results show that the combination of polyurethane-35 and calcium hydrogen phosphate with calcium lactate has a longer effect on prolonging the stain resistance of teeth than the combination of polyurethane-35 and calcium lactate.

[0129] The correlation between the three components and their anti-staining properties

[0130] {X}: Indicates the stain resistance (expressed as a percentage change in color gradation) of the formulation containing only polyurethane-35.

[0131] {Y}: Indicates the stain resistance of the formulation containing only dicalcium phosphate (expressed as a percentage change in color gradation).

[0132] {Z}: Indicates the stain resistance of the formula containing only calcium lactate (expressed as a percentage change in color gradation).

[0133] {X+Y}: Represents the stain resistance of the polyurethane-35 and dicalcium phosphate combination formulation (expressed as a percentage change in color gradation).

[0134] {X+Z}: Indicates the stain resistance of the polyurethane-35 and calcium lactate combination formulation (expressed as a percentage change in color gradation).

[0135] {X+Y+Z}: Represents the stain resistance of the polyurethane-35 formulation combined with dicalcium phosphate and calcium lactate (expressed as a percentage change in color gradation).

[0136] from Figure 6-3 The results showed that the combination of polyurethane-35 and dicalcium phosphate had at least an additive effect, with color gradation changes of 80.45% and 67.24% at the 4th hour, respectively, yielding the relationship {X+Y}≧1.23{X}. Figure 7 The results showed that the combination of polyurethane-35 and calcium lactate had at least an additive effect, with color gradation changes of 80.45% and 86.2% at the 4th hour, respectively, yielding the relationship {X+Z}≧1.03{X}. Figure 8 The results showed that the combination of polyurethane-35, dicalcium phosphate, and calcium lactate had at least an additive effect, with color gradation changes of 46.66% and 43.21% at the 4th hour, respectively, leading to the relationship {X+Y+Z}≧1{X+Y}. Figure 9The results showed that the combination of polyurethane-35, dicalcium phosphate and calcium lactate had at least an additive effect, with color gradation changes of 82.75% and 67.24% at the 4th hour. The relationship {X+Y+Z}≧1.37{X+Z} was obtained. From the above, it can be seen that the combination formulation in this concentration range has at least an additive effect on the anti-staining power of teeth.

[0137] Synergistic effect of the three components on anti-staining properties

[0138] The combination index (CI) proposed by TCChou et al. and L. Zhao et al. was used to assess the interaction between the two reagents. If CI < 1, the combined reagents have a synergistic effect; if CI ≥ 1, the combined reagents have an additive effect; if CI > 1, the combined reagents have an antagonistic effect. The larger the CI value, the greater the likelihood of an antagonistic effect.

[0139] A. Synergistic effect of polyurethane-35 and calcium hydrogen phosphate

[0140] The test was conducted with a 6-hour endpoint. The time corresponding to a 70% change in color recovery rate for different formulations was used as the calculated value, and the time for each concentration to reach a 70% change was defined as CI. 70％ The formula is as follows:

[0141]

[0142] The calculated CI value was approximately 0.81, confirming that the combination of polyurethane-35 and dicalcium phosphate has a synergistic effect.

[0143] B. Synergistic effect of polyurethane-35 and calcium lactate

[0144] The test was conducted with a 6-hour endpoint. The time corresponding to a 70% change in color recovery rate for different formulations was used as the calculated value, and the time for each concentration to reach a 70% change was defined as CI. 70％ The formula is as follows:

[0145]

[0146] The calculated CI value was approximately 0.812, confirming the synergistic effect of the combination of polyurethane-35 and calcium lactate.

[0147] C. Synergistic effect of polyurethane-35, calcium hydrogen phosphate and calcium lactate

[0148] The test was conducted at a time of six hours. Due to the significant synergistic effect of the three raw materials, the time corresponding to a 45% change in color recovery rate for different formulations was used as the calculation value, and the time for each concentration to reach a 45% change was defined as CI45.

[0149] I. Synergistic effect of polyurethane-35 combined with calcium hydrogen phosphate and calcium lactate

[0150]

[0151] The calculated CI value is approximately 0.04, confirming a synergistic effect between polyurethane-35 and calcium dicalcium phosphate and calcium lactate. II. Synergistic effect of polyurethane-35 combined with calcium lactate and calcium dicalcium phosphate.

[0152]

[0153] The calculated CI value was approximately 0.04, confirming the synergistic effect of polyurethane-35 in combination with calcium lactate and calcium hydrogen phosphate.

[0154] The above experimental results confirm that polyurethane-35 combined with dicalcium phosphate and polyurethane-35 combined with calcium lactate have a synergistic effect; the combination formulation containing polyurethane-35, dicalcium phosphate and calcium lactate also has a synergistic effect.

[0155] Example 9

[0156] Collected adult human molars were cleaned of dirt using ultrasonic agitation with 37% phosphoric acid and ultrapure water, and then soaked in concentrated black coffee staining solution at 37±2.5℃ for 48 hours to stain the teeth. Afterwards, the teeth were soaked in different reagents according to the following methods, and the tooth color gradation was recorded using a VITA tooth shade guide card and a camera (Canon M6 Mark II).

[0157] The stained teeth were divided into a blank group, a whitening group, and an anti-staining group. Three teeth (N=3) were tested in each group. Statistical analysis was performed using a t-test, with the group mean used as the basis for calculating the t-test. The following procedures were followed for each group:

[0158] (i) Control group: The teeth were immersed in ultrapure water for 25 minutes every day, then rinsed with ultrapure water (simulating mouth rinsing) and placed in PBS simulated culture medium (simulating oral environment) and cultured at 37℃±2.5℃ for 24 hours. The steps were repeated for 7 days.

[0159] (ii) Non-anti-staining treatment group: The teeth were soaked in whitening gel (see Table 1B) for 25 minutes every day, then rinsed with ultrapure water and placed in PBS simulated culture medium and cultured at 37℃±2.5℃ for 24 hours. The steps were repeated for 7 days.

[0160] (iii) Anti-staining treatment group: The teeth were soaked in whitening gel (refer to Table 1B) for 25 minutes every day, rinsed with ultrapure water, soaked in anti-staining gel (refer to Table 1A) for 15 minutes, rinsed with ultrapure water, and placed in PBS simulated culture medium and cultured at 37℃±2.5℃ for 24 hours. The steps were repeated for 7 days.

[0161] Subsequently, the teeth of the untreated and anti-stained groups were immersed in concentrated black coffee staining solution at 37±2.5℃ for 18 hours. The correlation between tooth color change and pigment accumulation time was observed every 15 minutes using a VITA tooth color chart and a camera (Canon M6 Mark ii).

[0162] Teeth whitening effect

[0163] Based on the above, the whitening test results for the blank group, the non-anti-staining treatment group, and the anti-staining treatment group over a 7-day period are as follows: Figure 10 As shown. From Figure 10 It is clear that the blank group had no teeth whitening effect, while both the untreated and anti-staining groups showed significant teeth whitening effects. During the 7-day trial, the untreated and anti-staining groups reduced the shade by an average of 21 and 25.6 shades, respectively. The anti-staining group showed the best teeth whitening effect, outperforming the untreated group by 4.5 shades.

[0164] Teeth stain resistance

[0165] After a 7-day whitening test, the untreated and treated groups were placed in black coffee staining solution for further analysis of the anti-staining effect of the anti-staining gel. The results are as follows: Figure 11 As shown. From Figure 11 It can be seen that, during the observation period of 15 minutes, in the first two hours, the teeth in the untreated group showed little resistance to coffee pigment, rising from shade 9 to shade 29 after two hours, with a 100% color return rate. In contrast, the teeth in the anti-staining group showed resistance to coffee pigment, rising from shade 3 to shade 16 after two hours, with a color return rate of only 46.2%; after six hours, the color return rate was 80%. In comparison, teeth treated with the anti-staining composition of this disclosure effectively enhance their resistance to coffee pigment. In other words, the anti-staining composition of this disclosure can prolong the whitening effect of the teeth whitening agent of this disclosure, helping to delay the adhesion of pigments after teeth whitening.

[0166] The results of the above embodiments show that teeth treated with the tooth stain-resistant composition of this disclosure have better stain resistance than teeth not treated with the tooth stain-resistant composition of this disclosure, and can prolong the stain resistance time. Furthermore, based on safety and the teeth's resistance to coffee staining, within a safe concentration range, the tooth stain-resistant composition containing 30% polyurethane-35 most effectively enhances the teeth's resistance to coffee pigments for six hours. The tooth stain-resistant composition containing 3% polyurethane-35 also maintains the teeth's resistance to coffee pigments even after being immersed in coffee for six hours.

[0167] According to the anti-staining efficacy results, the polyurethane-35 combined with dicalcium phosphate or calcium lactate formulations are more effective than the polyurethane-35 formulation in improving the anti-staining ability of teeth exposed to coffee environments over long periods or frequently. Figure 8 and Figure 9 The results showed that the polyurethane-35 formula with dicalcium phosphate and calcium lactate was more effective in improving the stain resistance of teeth when exposed to coffee for a long time or frequently than the polyurethane-35 formula without or with dicalcium phosphate or calcium lactate. Even teeth that were soaked in coffee for six hours still had a stain resistance to coffee pigments.

[0168] In addition, adding a certain proportion of dicalcium phosphate and calcium lactate to the anti-staining composition containing polyurethane-35 can assist polyurethane-35 in enhancing the anti-staining power of teeth and significantly improve the long-term anti-staining effect of teeth.

[0169] List of implementation methods

[0170] The following exemplary implementations are provided, and their numbers should not be interpreted as indicating a degree of importance.

[0171] Embodiment 1 provides a tooth staining composition comprising 3% to 30% by weight of polyurethane and 0.1% to 25% by weight of dicalcium phosphate, as well as other oral-acceptable carriers and / or excipients.

[0172] Embodiment 2 provides a tooth staining composition as described in Embodiment 1, which further comprises 0.1% to 25% calcium lactate by weight of the tooth staining composition.

[0173] Embodiment 3 provides a tooth staining composition as described in Embodiment 1 or 2, which further comprises 2.5% to 30% polyvinylpyrrolidone, 0.2% to 20% acrylate copolymer and / or 0.1% to 25% titanium dioxide by weight of the tooth staining composition, and the total weight of all components in the tooth staining composition is 100%.

[0174] Embodiment 4 provides a tooth stain-resistant composition as described in any one of Embodiments 1 to 3, further comprising water.

[0175] Embodiment 5 provides a tooth stain-resistant composition as described in any one of Embodiments 1 to 3, further comprising at least one wetting agent.

[0176] Embodiment 6 provides a tooth stain-resistant composition as described in Embodiment 5, wherein the wetting agent is selected from the group consisting of sorbitol, glycerin, xylitol, propylene glycol, or combinations thereof.

[0177] Embodiment 7 provides a tooth stain-resistant composition as described in any one of Embodiments 1 to 3, further comprising at least one surfactant.

[0178] Embodiment 8 provides a tooth stain-resistant composition as described in Embodiment 7, wherein the surfactant is selected from the group consisting of polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 65, polysorbate 80, or combinations thereof.

[0179] Embodiment 9 provides a tooth stain-resistant composition as described in any one of Embodiments 1 to 3, further comprising at least one potassium salt as an anti-sensitivity agent.

[0180] Embodiment 10 provides a tooth stain-resistant composition as described in Embodiment 9, wherein the potassium salt is selected from the group consisting of potassium citrate, potassium nitrate, potassium chloride, or combinations thereof.

[0181] Embodiment 11 provides a tooth stain-resistant composition as described in any one of Embodiments 1 to 3, further comprising at least one antibacterial agent or preservative.

[0182] Embodiment 12 provides a tooth staining composition as described in Embodiment 11, wherein the antibacterial agent or preservative is selected from the group consisting of phenoxyethanol, benzoic acid, salicylic acid, p-hydroxybenzoic acid, methylparaben, chlorphenesin, ethylhexylglycerin, or combinations thereof.

[0183] Embodiment 13 provides a tooth staining composition as described in any one of Embodiments 1 to 3, further comprising at least one flavoring agent.

[0184] Embodiment 14 provides a tooth staining composition as described in Embodiment 13, wherein the flavoring agent comprises essential oils and various flavoring aldehydes, esters and alcohols, wherein examples of the essential oils include oil extracts of lemon, lime, grapefruit, orange, peppermint, wintergreen, sassafras, clove, sage, spearmint, marjoram and cinnamon.

[0185] Embodiment 15 provides a tooth staining composition as described in Embodiment 13, wherein the flavoring agent comprises acesulfame potassium, ethyl menthane formamide, menthol, carvone, or anethole.

[0186] Embodiment 16 provides a tooth stain-resistant composition as described in any one of Embodiments 1 to 3, further comprising at least one abrasive.

[0187] Embodiment 17 provides a tooth stain-resistant composition as in Embodiment 16, wherein the abrasive is selected from the group consisting of aluminum hydroxide, aluminum silicate, dicalcium phosphate, silica, calcium carbonate, bentonite, or combinations thereof.

[0188] Embodiment 18 provides a tooth staining composition as described in any one of Embodiments 1 to 17, which is in the form of a solution, slurry, gel, paste or ointment.

[0189] Embodiment 19 provides a tooth staining kit comprising the tooth staining composition described in any one of Embodiments 1 to 17 and instructions for use.

[0190] Embodiment 20 provides a teeth whitening and anti-staining kit, which includes the teeth anti-staining composition, teeth whitening composition and instructions for use as described in any one of Embodiments 1 to 17.

[0191] Embodiment 21 provides a method for preventing tooth staining, which includes applying the tooth staining composition of any one of Embodiments 1 to 17 to the tooth surface for a period of time, and then rinsing the mouth with water to remove the tooth staining composition that is not adhered to the tooth surface.

[0192] Embodiment 22 provides a tooth anti-staining method as described in Embodiment 21, wherein the teeth have been whitened with a teeth whitening agent before the tooth anti-staining composition is applied.

[0193] Embodiment 23 provides a tooth staining method as described in Embodiment 21, wherein the tooth has been cleaned with a dental cleaning agent before the tooth staining composition is applied.

Claims

1. A tooth staining composition comprising 3% to 30% by weight of polyurethane, 0.1% to 25% by weight of dicalcium phosphate and 0.1% to 25% by weight of calcium lactate, and an oral-acceptable carrier and / or excipient.

2. The tooth staining composition according to claim 1, further comprising 2.5% to 30% polyvinylpyrrolidone, 0.2% to 20% acrylate copolymer and / or 0.1% to 25% titanium dioxide by weight of the tooth staining composition, and the total weight of all components in the tooth staining composition is 100%.

3. The tooth staining composition according to claim 1, wherein the oral-acceptable carrier and / or excipient is selected from one or more of the group consisting of humectants, surfactants, antisensitizers, antibacterial agents or preservatives, flavoring agents and abrasives.

4. The tooth stain-resistant composition according to claim 1, wherein it is in the form of a solution, slurry, gel, paste or ointment.

5. A tooth staining kit comprising a tooth staining composition according to any one of claims 1 to 3 and instructions for use.

6. A teeth whitening and anti-staining kit comprising a teeth anti-staining composition, a teeth whitening composition, and instructions for use according to any one of claims 1 to 3.

7. A method for resisting tooth staining, comprising applying a tooth staining composition according to any one of claims 1 to 3 to a tooth surface for a period of time, and then rinsing the mouth with water to remove the tooth staining composition that is not adhered to the tooth surface.

8. The method for resisting tooth staining according to claim 7, wherein the teeth have been whitened with a teeth whitening agent before the application of the tooth staining composition.

9. The method for preventing tooth staining according to claim 7, wherein the teeth have been cleaned with a dental cleaning agent before the tooth staining composition is applied.

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