Blood circulation circuit

Abstract

Provided is a blood circulation circuit capable of reducing manufacturing costs and maintenance costs. A blood circulation circuit (1) includes a blood removal line (2) that removes venous blood, a blood reservoir (4) that is connected to the blood removal line (2) and stores blood that has flowed through the blood removal line (2), a negative pressure adjustment device (6) that adjusts the negative pressure inside the blood reservoir (4), a blood pump (5) that transports the blood of the blood reservoir (4), an artificial lung (7) that performs gas exchange on the blood that has been sent from the blood pump (5), and a blood recovery line (3) that is connected to the blood reservoir (4) and sucks blood from a surgical site by the negative pressure of the blood reservoir (4).

Description

Technical Field

[0001] This invention relates to blood circulation circuits. Background Technology

[0002] Previously, in cardiac surgery, blood circulation circuits equipped with artificial lungs were used to replace the patient's circulatory function during surgery. The blood circulation circuit includes: a devascularized tubing that draws blood from a large vein; a blood reservoir connected to the devascularized tubing and storing the blood flowing in from it; a blood pump that delivers blood from the blood reservoir; an artificial lung that performs gas exchange on the blood pumped out; a negative pressure regulator that adjusts the negative pressure inside the blood reservoir; and blood recovery tubing, which serves as a suction line and a vent line for drawing blood from the surgical field, etc.

[0003] Here, the flow rate of blood flowing through the blood return tubing needs to be adjusted differently from the flow rate of blood flowing through the devascularized tubing; therefore, roller pumps have traditionally been installed in the blood return tubing. However, roller pumps are expensive and need to be replaced every few years. In recent years, there has been a growing trend to control equipment investment from the perspective of reducing medical costs. Therefore, there have been instances of roller pumps being used beyond their service life, and from a safety perspective, it is undesirable to use blood circulation circuits with roller pumps that have exceeded their service life in clinical practice.

[0004] Therefore, the following blood circulation loop is proposed: For the blood recovery pipeline, the blood is temporarily drawn into a blood recovery tank that is different from the blood storage tank and whose negative pressure can be adjusted by a negative pressure regulating device that is different from the negative pressure regulating device installed in the blood storage tank, and then the blood is transported to the blood storage tank (see Patent Document 1).

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: European Patent No. 2123315 Specification Summary of the Invention

[0008] The problem that the invention aims to solve

[0009] However, the blood circulation circuit proposed in Patent Document 1 requires two slots and two negative pressure regulating devices, which cannot reduce the manufacturing cost of the blood circulation circuit.

[0010] Therefore, the object of the present invention is to provide a blood circulation circuit that can reduce manufacturing costs.

[0011] Methods for solving problems

[0012] This invention relates to a blood circulation circuit comprising: a devascularization circuit for devascularizing venous blood; a blood storage tank connected to the devascularization circuit for storing blood flowing through the devascularization circuit; a negative pressure regulating device for regulating the negative pressure inside the blood storage tank; a blood pump for delivering blood from the blood storage tank; an artificial lung for gas exchange with blood delivered from the blood pump; and a blood recovery line connected to the blood storage tank for aspirating blood from the surgical site through the negative pressure of the blood storage tank.

[0013] In addition, the blood circulation circuit preferably includes a first flow regulating device for regulating the flow rate of blood flowing through the aforementioned blood recovery pipeline.

[0014] In addition, the aforementioned first flow regulating device preferably regulates the flow rate by changing the catheter opening area by externally pressing the catheter used in the aforementioned blood recovery pipeline in a non-contact state with blood.

[0015] In addition, the aforementioned blood circulation circuit preferably includes a second flow regulating device for regulating the flow rate of blood flowing through the aforementioned devascularized circuit.

[0016] In addition, the aforementioned second flow regulating device preferably regulates the flow rate by changing the catheter opening area by externally pressing the catheter used in the aforementioned devascularization circuit in a non-contact state with blood.

[0017] Invention Effects

[0018] According to the present invention, a blood circulation circuit that can reduce manufacturing costs can be provided. Attached Figure Description

[0019] [ Figure 1 [Illustration 1] is a diagram showing the configuration of the blood circulation circuit 1 according to the first embodiment of the present invention.

[0020] [ Figure 2 [ ] is a diagram showing the configuration of the blood circulation circuit 1A according to the second embodiment of the present invention. Detailed Implementation

[0021] Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. Figure 1 This is a diagram illustrating the configuration of the blood circulation circuit 1 according to the first embodiment. The blood circulation circuit 1 of the first embodiment is applied, for example, to an artificial heart-lung system used during cardiac surgery.

[0022] The blood circulation circuit 1 includes: a devascularization line 2, a blood recovery line 3, a blood storage tank 4, a blood pump 5 that delivers blood from the blood storage tank 4, a negative pressure regulating device 6 that regulates the negative pressure inside the blood storage tank 4, an artificial lung 7, a blood filtration device 8, and a delivery line 9.

[0023] The devascularization line 2, blood recovery line 3, and blood delivery line 9 are made of flexible polyvinyl chloride or other catheters.

[0024] The devascularization line 2 and the blood recovery line 3 are respectively equipped with a first flow regulating device 10 and a second flow regulating device 11 to regulate the flow rate of blood flowing through the inside of the catheter.

[0025] (Devascularization route 2)

[0026] The devascularization circuit 2 is connected to the large vein located near the heart H, and delivers the blood (venous blood) flowing through the large vein to the blood storage tank 4.

[0027] (Blood recovery tubing 3)

[0028] Blood recovery tubing 3 is used to absorb blood present in the surgical field and blood present in the heart chamber H. Blood recovery tubing 3 is not limited to one line; there can be two or more.

[0029] (Blood Tank 4)

[0030] Blood storage tank 4 stores blood that has flowed through devascularization line 2 and blood recovery line 3. Blood storage tank 4 is connected to devascularization line 2 and blood recovery line 3.

[0031] (Blood Pump 5)

[0032] A blood pump 5 is positioned downstream of the blood reservoir 4 to deliver blood from the reservoir 4 to the artificial lung 7, allowing the blood to circulate within the blood circulation loop 1. A known centrifugal pump or roller pump is used as the blood pump 5. In this embodiment, a centrifugal pump is used as the blood pump 5, which compresses the blood by driving a rotating body located inside.

[0033] (Artificial Lung 7)

[0034] The artificial lung 7 is positioned downstream of the blood pump 5 and is equipped with a hollow fiber membrane or flat sheet membrane with excellent gas permeability. The artificial lung 7 performs gas exchange, such as adding oxygen to the blood and removing carbon dioxide from the blood. The artificial lung 7 is connected to an oxygen supply mechanism (not shown) such as an oxygen cylinder, from which oxygen added to the blood is supplied to the artificial lung 7. Additionally, the artificial lung 7 is, for example, equipped with a heat exchanger for regulating blood temperature.

[0035] (Blood filtration device 8)

[0036] The blood filtration device 8 filters the blood and removes air bubbles from it.

[0037] (Negative pressure regulating device 6)

[0038] The negative pressure regulating device 6 maintains a predetermined negative pressure inside the blood storage tank 4. For example, a VAVD controller can be used as the negative pressure regulating device 6.

[0039] (First flow regulating device 10 and second flow regulating device 11)

[0040] The first flow regulating device 10 is installed in the blood recovery line 3. In this embodiment, the first flow regulating device 10 is a non-contact blood device installed on the outside of the conduit constituting the blood recovery line 3.

[0041] The second flow regulating device 11 is installed on the detubation tube 2. In this embodiment, the second flow regulating device 11 is a non-contact blood device installed on the outside of the catheter constituting the detubation tube 2.

[0042] The first flow regulating device 10 and the second flow regulating device 11 clamp and flatten the catheter from the outside to change the flow rate of blood flowing through the catheter. In this embodiment, the flow control of the first flow regulating device 10 and the second flow regulating device 11 is performed manually, but it is not limited to this and can also be performed electrically. Whether manually or electrically, the first flow regulating device 10 and the second flow regulating device 11 can narrow the catheter from the outside and can be easily controlled in multiple stages or without stages.

[0043] In this embodiment, the first flow regulating device 10 and the second flow regulating device 11 include: a cylindrical main body; a catheter inlet portion that can insert a catheter, which is formed by cutting off a portion of the side of the main body; a clamping member that is disposed inside the main body in a manner that can move forward and backward in the axial direction of the main body, and clamps the catheter inserted by the catheter inlet portion from the outside; and an operating part disposed at the axial end of the main body, which moves the clamping member forward and backward by rotation.

[0044] Based on the first flow regulating device 10 and the second flow regulating device 11 described above, with the catheter constituting the blood recovery line 3 and the catheter constituting the devascularization line 2 inserted into the catheter inlet, the clamping member is moved forward and backward by rotating the operating part. Thus, by clamping and flattening the catheter from the outside to achieve clamping, the flow rate of blood flowing through the catheter can be changed. Furthermore, the first flow regulating device 10 and the second flow regulating device 11 are easy to install and remove from the catheter. In addition, to control the flow of the catheter from the outside, a flow regulating mechanism such as a roller pump can reduce blood damage.

[0045] In this embodiment, the first flow regulating device 10 and the second flow regulating device 11 are made of materials capable of sterilization, such as metal parts.

[0046] Next, the operation of the blood circulation circuit 1 in this embodiment will be explained.

[0047] When using blood circulation circuit 1, the disconnection line 2 is connected to a large vein near the heart (H), and the delivery line 9 is connected to a large artery near the heart (H). Additionally, the blood recovery line 3 is positioned in the prescribed location, such as the surgical field.

[0048] Then, when the negative pressure regulating device 6 and the blood pump 5 are running, the inside of the blood storage tank 4 becomes negative pressure. Due to the negative pressure inside the blood storage tank 4, venous blood is drawn from the vena cava to the devascularization line 2, and the drawn blood is stored in the blood storage tank 4. The blood stored in the blood storage tank 4 is transported to the artificial lung 7 by the blood pump 5. In the artificial lung 7, gas exchange is performed to oxygenate the blood transported to the artificial lung 7 and remove carbon dioxide. In addition, the temperature of the blood passing through the artificial lung 7 is regulated. Furthermore, the blood is filtered in the blood filtration device 8, and the filtered blood is returned to the aorta near the heart H via the delivery line 9.

[0049] Furthermore, due to the negative pressure inside the blood storage tank 4, the inside of the blood recovery line 3 also becomes negative pressure, and blood is also drawn into the blood recovery line 3. Thus, by drawing blood from the surgical field through the blood recovery line 3, it is possible to prevent blood from bleeding in the surgical field from covering the lesion and making it impossible to see, thereby preventing the continuation of the surgery. Moreover, blood loss due to bleeding is kept to a minimum.

[0050] According to the above-described embodiment, by adjusting the negative pressure by the negative pressure regulating device 6 connected to the blood storage tank 4, blood can be drawn not only from the devascularization line 2 but also from the blood recovery line 3. That is, even without equipping the blood recovery line 3 with a roller pump or other blood suction mechanism, blood can be recovered from the blood recovery line 3.

[0051] Furthermore, the amount of venous blood aspirated via the devascularization line 2 and the amount of intraoperative bleeding aspirated via the blood recovery line 3 varies depending on the circumstances. Therefore, it is sometimes not preferable to perform blood aspiration via the devascularization line 2 and the blood recovery line 3 under the same negative pressure, and the aspiration volume needs to be changed depending on the situation.

[0052] In this embodiment, a first flow regulating device 10 is disposed in the blood recovery line 3, and a second flow regulating device 11 is disposed in the detubation line 2. Thus, by appropriately adjusting the first flow regulating device 10 and the second flow regulating device 11, the flow rate of blood drawn through the detubation line 2 and the blood recovery line 3 can be changed.

[0053] At this time, for example, if the flow regulating device 10 is only configured in the blood recovery line 3, the negative pressure of the blood recovery line 3 cannot be greater than that of the decompression line 2. However, in the embodiment, since the flow regulating device 11 is also configured in the decompression line 2, the negative pressure of the blood storage tank 4 can also be increased by the negative pressure regulating device 6, so that the negative pressure of the blood recovery line 3 is greater than that of the decompression line 2.

[0054] Therefore, since there is no need for a blood suction mechanism such as a roller pump for the blood recovery tubing 3, a compact and inexpensive blood circulation circuit 1 can be provided. Furthermore, since there is no need to replace the blood suction mechanism such as the roller pump, the maintenance costs of the blood circulation circuit 1 can be reduced.

[0055] Furthermore, in this embodiment, the flow rate is adjusted by the first flow rate regulating device 10 as follows: blood is drawn from the blood recovery line 3 using a negative pressure regulated by the negative pressure regulating device 6, and the catheter opening area is changed by externally closing the catheter used in the blood recovery line 3 in a non-contact state with the blood. Therefore, for example, if it is necessary to draw blood from multiple surgical sites, this can be easily handled by installing multiple sets of blood recovery lines 3 and the first flow rate regulating device 10. This reduces costs compared to equipping multiple blood pumps for blood drawing in each of the multiple blood recovery lines. Additionally, the number of blood recovery lines can be changed without complicating the control of the blood circulation loop. It should be noted that multiple flow rate regulating devices can also be installed in a single blood recovery line.

[0056] Furthermore, when adjusting the flow rate of the blood recovery tubing 3 using tweezers, it is only possible to control whether the blood flow is blocked or not. However, in this embodiment, the first flow rate adjustment device 10 allows for multi-stage changes in the pressure applied to the catheter, thus enabling multi-stage changes in the flow rate.

[0057] Furthermore, the first flow regulating device 10 and the second flow regulating device 11 are used as devices that adjust the flow rate by changing the catheter opening area by externally compressing the catheter in a non-contact state with blood. Thus, the first flow regulating device 10 can be positioned at a desired location in the blood recovery line 3, and the second flow regulating device 11 can be positioned at a desired location in the devascularization line 2. Therefore, by manufacturing the first flow regulating device 10 and the second flow regulating device 11 with sterilizable materials, and positioning the first flow regulating device 10 and / or the second flow regulating device 11 within the reach of the surgeon, the surgeon can operate the first flow regulating device 10 and / or the second flow regulating device 11 to adjust the flow rate.

[0058] Next, refer to Figure 2 The blood circulation circuit 1A of the second embodiment will be described. The blood circulation circuit 1A of the second embodiment differs from that of the first embodiment in that it includes a blood concentration circuit 91; and it includes a myocardial protection circuit 92 and a brain separation circuit 93 as blood delivery circuits. It should be noted that in describing the second embodiment, the same reference numerals are used for the same components, and their descriptions are omitted or simplified.

[0059] The blood concentration circuit 91 includes: a blood return line 911, a blood purifier 912 disposed in the blood return line 911, and a third flow regulating device 913.

[0060] One end of the blood return line 911 is connected between the blood pump 5 and the artificial lung 7, and the other end is connected to the upper part of the blood storage tank 4. A portion of the blood pumped from the blood pump 5 flows into the blood return line 911 and is returned to the blood storage tank 4.

[0061] The blood purifier 912 is positioned midway through the blood return line 911. Blood flowing through the blood return line 911 is introduced into the blood purifier 912. The blood purifier 912 removes excess water and waste from the blood.

[0062] The third flow regulating device 913 has the same configuration as the first flow regulating device 10 and the second flow regulating device 11. The third flow regulating device 913 is installed on the outside of the catheter constituting the blood return line 911. The third flow regulating device 913 clamps and flattens the catheter from the outside to change the flow rate of blood flowing through the catheter.

[0063] According to the blood concentration circuit 91 described above, a portion of the blood pumped from the blood pump 5 is introduced into the blood return line 911. Furthermore, the blood introduced into the blood return line 911 is dehydrated and purified by the blood purification device 912 before being returned to the blood storage tank 4. Additionally, the flow rate of the blood flowing through the blood return line 911 is regulated by the third flow rate regulating device 913.

[0064] The myocardial protection circuit 92 and the brain separation circuit 93 are provided so that the blood delivery destination of the blood delivery line 9 in the first embodiment can be multiple sites, depending on the purpose. That is, it can also be said that the blood circulation circuit 1A in the second embodiment has multiple blood delivery lines.

[0065] The myocardial protection circuit 92 includes: a myocardial protection line 921 and a fourth flow regulating device 922 disposed in the myocardial protection line 921.

[0066] One end of the myocardial protection line 921 is connected to the downstream side of the blood supply line 9, which is closer to the blood filtration device 8, and the other end is connected to the coronary artery, etc.

[0067] The fourth flow regulating device 922 has the same configuration as the first flow regulating device 10, the second flow regulating device 11, and the third flow regulating device 913. The fourth flow regulating device 922 is installed on the outside of the catheter constituting the myocardial protection line 921. The fourth flow regulating device 922 clamps and flattens the catheter from the outside to change the flow rate of blood flowing through the catheter.

[0068] The flow rate of blood flowing through the myocardial protection line 921 is regulated by the fourth flow regulating device 922.

[0069] The brain separation circuit 93 includes: a brain separation conduit 931 and a fifth flow regulating device 932 disposed in the brain separation conduit 931.

[0070] One end of the brain separation tube 931 is connected to the downstream side of the blood supply tube 9, which is closer to the blood filtration device 8, and the other end is connected to the carotid artery, etc.

[0071] The fifth flow regulating device 932 has the same configuration as the first flow regulating device 10, the second flow regulating device 11, the third flow regulating device 913, and the fourth flow regulating device 922. The fifth flow regulating device 932 is installed on the outside of the catheter constituting the brain separation conduit 931. The fifth flow regulating device 932 clamps and flattens the catheter from the outside to change the flow rate of blood flowing through the catheter.

[0072] Based on the brain separation circuit 93 described above, a portion of the blood flowing through the blood supply line 9 is diverted into the brain separation tube 931 to deliver blood to the carotid artery and other arteries, thereby protecting brain function. The flow rate of blood flowing through the brain separation tube 931 is regulated by the fifth flow regulating device 932.

[0073] The blood circulation circuit 1A according to the second embodiment described above achieves the same effects as the first embodiment. Specifically, the third flow regulating device 913, the fourth flow regulating device 922, and the fifth flow regulating device 932 use devices that adjust the flow rate by changing the catheter opening area by externally pressing the catheter closed in a non-contact state with blood. Therefore, when refluxing blood to multiple sites within the patient's body, the amount of blood refluxing can be easily adjusted according to the refluxing site.

[0074] The preferred embodiments of the blood circulation circuit 1 of the present invention have been described above, but the present invention is not limited to the above embodiments. For example, the blood return line from the blood filtration device to the patient may be two lines instead of one.

[0075] Explanation of reference numerals in the attached figures

[0076] 1.1A blood circulation circuit

[0077] 2. Devascularization

[0078] 3 Blood recovery tubing

[0079] 4 blood tanks

[0080] 5 blood pumps

[0081] 6 Negative pressure regulating devices

[0082] 7 artificial lungs

[0083] 8 Blood filtration devices

[0084] 9. Vascular pathway

[0085] 10 First Flow Regulator

[0086] 11. Flow regulating device No. 2

Claims

1. A blood circulation circuit, which includes: Devascularization circuit, which removes blood from venous blood; A blood storage tank, which is connected to the devascularization circuit, stores the blood flowing through the devascularization circuit; A negative pressure regulating device that regulates the negative pressure inside the blood storage tank; A blood pump that delivers blood to the blood reservoir; An artificial lung that performs gas exchange on blood pumped from the blood; A blood recovery pipeline is connected to the blood storage tank, and blood is drawn from the surgical site through the negative pressure of the blood storage tank; A first flow regulating device for regulating the flow rate of blood flowing through the blood recovery pipeline; and A second flow regulating device for regulating the flow rate of blood flowing through the devascularized blood passage.

2. The blood circulation circuit as described in claim 1, wherein, The first flow regulating device adjusts the flow rate by changing the catheter opening area by externally closing the catheter used in the blood recovery pipeline in a non-contact state with blood.

3. The blood circulation circuit as described in claim 1, wherein, The second flow regulating device adjusts the flow rate by changing the catheter opening area by externally closing the catheter used in the devascularization circuit in a non-contact state with blood.

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