A kind of enantiotesenane type diterpene lactone compound and its preparation method and application
Extraction from herbs was obtained by extracting from the eptulaeum and purifying it by multi-step chromatography to obtain a 6/6/7 ring-based enantiosenoxa alkyl diterpenetone compound with anti-acetylcholinesterase activity, and the extraction from herbs was solved The problem of inhibiting acetylcholinesterase provides new drug development ideas for the treatment of Alzheimer's disease.
CN117105903BActive Publication Date: 2024-12-20SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE) +1
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Patent Information
- Application Number
- CN202310901545.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-07-21
- Publication Date
- 2024-12-20
- Estimated Expiration
- 2043-07-21
AI Technical Summary
Technical Problem
The prior art is difficult to extract natural products with inhibitory acetylcholinesterase from herbs for the treatment of Alzheimer's disease.
Method used
By extracting from the dried roots of Euphorbia and purifying by multi-step chromatography, a 6/6/7 ring-based enantiosenoxa alkyl diterpene lactone compound has good anti-acetylcholinesterase activity .
Benefits of technology
The extraction of compounds with inhibitory acetylcholinesterase from Euphorbia has provided new ideas and ways to prepare drugs for preventing or treating Alzheimer's disease, which has significant development value.
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Abstract
The present invention and the technical field of natural medicines particularly relate to an enantiopysenane-type diterpene lactone compound and a preparation method and application thereof. The enantiopysenane-type diterpene lactone compound has a structure as shown in Formula I, and the preparation method comprises the following steps: using the dried root of Euphorbia chamaejasme as a raw material, extracting by filtration and concentrating to obtain an extract and suspending it in water to obtain a suspension, extracting and concentrating to obtain an extract; taking the extract and eluting and purifying it by ODS liquid chromatography after gradient elution to obtain the compound shown in Formula I. The present invention realizes the extraction of a 6 / 6 / 6 / 7 ring system enantiopysenane-type diterpene lactone compound with acetylcholinesterase inhibition from Euphorbia chamaejasme for the first time, and has great development value as a new drug for the prevention or treatment of Alzheimer's disease. The design idea of such a compound also provides a new idea and approach for the development of a new drug for the prevention or treatment of Alzheimer's disease.
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