Atomizer and atomization method for adaptively generating medicament aerosol of different particle sizes

Abstract

A nebulizer that adaptively generates drug aerosols of different particle sizes includes a sensor module, a high-frequency oscillation circuit, a signal modulation module, a piezoelectric device, and a porous screen. The sensor module senses the patient's physical state, including respiratory status. A waveform pattern determination module generates a modulation control signal based on the patient's physical state. The high-frequency oscillation circuit provides a high-frequency oscillation signal. The signal modulation module modulates the high-frequency oscillation signal using the modulation control signal to generate a vibration signal. The piezoelectric device generates vibration based on the vibration signal. The porous screen, in response to the vibration of the piezoelectric device, compresses liquid drug through multiple holes in the porous screen to generate multiple drug aerosols corresponding to the particle size of the modulation control signal.

Description

Technical Field

[0001] This invention relates to an atomizer and atomization method for generating pharmaceutical aerosols, and more particularly to an atomizer and atomization method for adaptively generating pharmaceutical aerosols of different particle sizes according to the patient's physical condition, the medication used, or other factors. Background Technology

[0002] Pharmaceutical aerosols are atomized liquids containing drug particles. These aerosols can enter the upper and lower respiratory tracts and lungs, where they are absorbed to treat specific diseases. However, the particle size of pharmaceutical aerosols absorbed by different parts of the upper and lower respiratory tracts and lungs is not the same. The particle size of pharmaceutical aerosols is usually expressed as the mass medium aerodynamic diameter (MMAD).

[0003] For example, the median aerodynamic mass diameter of aerogels that can be absorbed in the upper respiratory tract (e.g., nose, throat, trachea) is approximately 5 to 50 micrometers (μm), or even greater than 50 micrometers; the median aerodynamic mass diameter of aerogels that can be absorbed in the lower respiratory tract is approximately 2 to 5 micrometers; the median aerodynamic mass diameter of aerogels that can be absorbed in the alveolar region is approximately 1 to 3 micrometers; and the median aerodynamic mass diameter of aerogels that can be absorbed in the thin-walled tissues of the lungs is approximately less than 0.1 micrometers.

[0004] For patients with different symptoms, it is necessary to deliver drug microparticles to different tissues. However, current nebulizers can only produce drug aerosols of a specific particle size. Therefore, multiple nebulizers producing drug aerosols of different particle sizes are needed to meet various treatment requirements. Furthermore, there are still individual differences among patients. Therefore, even drug aerosols targeting the same tissue may need to have different particle sizes to achieve precision treatment. Alternatively, different drugs may require different aerosol particle sizes for absorption.

[0005] For example, in treating a sore throat, patient A's throat can effectively absorb 40-micron aerosols, while patient B can only effectively absorb 45-micron aerosols. Similarly, in treating alveolar infections, 2-micron aerosols of drug C can be effectively absorbed by patient A's alveoli, but only 3-micron aerosols of drug D can be effectively absorbed by patient A's alveoli. In short, there is a need for a nebulizer and nebulization method that adaptively generates aerosols of different particle sizes based on the patient's physical condition, the drug used, or other factors. Summary of the Invention

[0006] The main objective of this invention is to provide a nebulizer and nebulization method that can adaptively generate drug aerosols of different particle sizes according to the patient's physical condition, the medication used, or other factors. Based on different patient physical conditions, different diseases, different medications, and different humidity or temperature factors, the nebulizer and nebulization method of this invention dynamically generate drug aerosols of different particle sizes, thereby achieving the goal of precise treatment.

[0007] This invention provides an nebulizer that adaptively generates drug aerosols of different particle sizes. The nebulizer includes a sensor module, a waveform pattern determination module, a high-frequency oscillation circuit, a signal modulation module, a piezoelectric device, and a porous screen. The sensor module senses the patient's physical state, including respiratory status. The waveform pattern determination module is electrically connected to the sensor module and generates a modulation control signal based on the patient's physical state. The high-frequency oscillation circuit provides a high-frequency oscillation signal. The signal modulation module is electrically connected to the waveform pattern determination module and the high-frequency oscillation circuit and modulates the high-frequency oscillation signal using the modulation control signal to generate a vibration signal. The piezoelectric device is electrically connected to the signal modulation module and generates vibration based on the vibration signal. The porous screen is physically connected to the piezoelectric device and, based on the vibration of the piezoelectric device, forces liquid drug through multiple holes in the porous screen to generate multiple drug aerosols corresponding to the particle size of the modulation control signal.

[0008] According to an embodiment of the present invention, the nebulizer further includes a data transmission interface. The data transmission interface is electrically connected to a waveform pattern determination module and is used to acquire auxiliary information, wherein a signal modulation module generates a modulation control signal based on the auxiliary information and the patient's physical condition, wherein the auxiliary information includes at least one of a drug type and a disease type, and the physical condition further includes at least one of the patient's facial expression, heart rate, heart rhythm, blood pressure, blood sugar, and body temperature.

[0009] According to an embodiment of the present invention, the nebulizer further includes a manual switch. The manual switch is electrically connected to a waveform pattern determination module for generating a switching signal based on the operation of the manual switch by the patient or operator, wherein the waveform pattern determination module further generates a modulation control signal based on the switching signal.

[0010] According to an embodiment of the present invention, the atomizer further includes an AC / DC converter and a power amplifier. The AC / DC converter is electrically connected to a high-frequency oscillation circuit and is used to convert the AC input voltage into a DC input voltage, so as to provide a high-frequency oscillation signal corresponding to the frequency of the DC input voltage generated by the high-frequency oscillation circuit. The power amplifier is electrically connected between the piezoelectric device and the signal modulation module, and is used to amplify the vibration signal and output the amplified vibration signal to the piezoelectric device.

[0011] According to an embodiment of the present invention, the waveform pattern determination module includes a signal processing module, a core computing module, and a modulation control signal generation module. The signal processing module is electrically connected to the sensor module and is used to perform noise filtering on the sensing signal of the body state. The core computing module is electrically connected to the signal processing module and is used to calculate the waveform pattern based on the noise-filtered sensing signal. The modulation control signal generation module is electrically connected to the core computing module and the signal modulation module, and generates a modulation control signal based on the calculated waveform pattern.

[0012] According to an embodiment of the present invention, the core computing module includes a neural network-based classifier to calculate waveform patterns based on the noise-filtered sensing signal.

[0013] According to an embodiment of the present invention, the sensor module includes a microphone module.

[0014] According to an embodiment of the present invention, the atomizer further includes a liquid container and a nozzle. The liquid container is used to contain a liquid medicine. The nozzle is disposed on the outer surface of the liquid container and is configured corresponding to a plurality of holes to spray a plurality of medicine aerosols.

[0015] According to an embodiment of the present invention, the signal modulation module includes a mixer and a filter module. The mixer is electrically connected to a high-frequency oscillation circuit and a waveform pattern determination module, and is used to mix the modulation control signal and the high-frequency oscillation signal to generate a mixed signal. The filter module is electrically connected to the mixer and a piezoelectric device, and is used to perform intermediate frequency filtering on the mixed signal to generate an vibration signal.

[0016] According to an embodiment of the present invention, the modulation control signal is one or a combination of a square wave, a triangle wave, and a sine wave.

[0017] This invention provides an adaptive atomization method for generating drug aerosols of different particle sizes, and this atomization method includes the following steps: A sensor module senses the patient's physical state, including respiratory state; a waveform pattern determination module generates a modulation control signal based on the physical state; a high-frequency oscillation circuit provides a high-frequency oscillation signal; a signal modulation module modulates the high-frequency oscillation signal with the modulation control signal to generate a vibration signal; and a piezoelectric device generates vibration based on the vibration signal to cause a porous screen to compress liquid drug through multiple holes in the porous screen to generate multiple drug aerosols corresponding to the particle size of the modulation control signal.

[0018] In summary, embodiments of the present invention provide a nebulizer and a nebulization method. This nebulizer and nebulization method acquire various factors and adjust the waveform pattern of the high-frequency oscillation signal accordingly to generate a drug aerosol that allows specific tissues of the patient to effectively absorb drug particles, thereby achieving the purpose of precision treatment. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the atomizer in use according to an embodiment of the present invention.

[0020] Figure 2 This is a functional block diagram of the atomizer according to an embodiment of the present invention.

[0021] Figure 3 This is a functional block diagram of the waveform pattern determination module in an embodiment of the present invention.

[0022] Figure 4 This is a schematic diagram of the piezoelectric device and porous screen generating pharmaceutical aerosol in an embodiment of the present invention.

[0023] Figure 5 This is a schematic flowchart of the atomization method according to an embodiment of the present invention.

[0024] Drawing number explanation:

[0025] 10: Atomizer

[0026] 11: Nozzle

[0027] 12: Sensor Module

[0028] 13: Waveform pattern determines the module

[0029] 131: Signal Processing Module

[0030] 132: Core Computing Module

[0031] 133: Modulation control signal generation module

[0032] 14: Signal Modulation Module

[0033] 15: High-frequency oscillation circuit

[0034] 16: AC / DC converter

[0035] 17: Power Amplifier

[0036] 18: Piezoelectric device

[0037] 19: Perforated screen

[0038] 191: Hole

[0039] 20: Pharmaceutical aerosol

[0040] 30: Patient

[0041] 31: Lungs

[0042] 40: Liquid medicine

[0043] CT: Liquid Container

[0044] DI: Data Transfer Interface

[0045] S51~S54: Steps

[0046] P: Manual switch. Detailed Implementation

[0047] Using pharmaceutical aerosols to treat patients requires consideration of multiple factors to generate one or more pharmaceutical aerosols of different particle sizes. In other words, adaptive generation of pharmaceutical aerosols with varying particle sizes is essential for achieving precise treatment. Therefore, this invention provides a nebulizer and nebulization method that acquires various factors (e.g., the patient's breathing status via a microphone and the type of medication used by the patient via a wireless communication interface) and adjusts the waveform of a high-frequency oscillation signal accordingly (e.g., generating a modulation control signal to modulate the intensity, frequency, or phase of the high-frequency oscillation signal as a carrier wave to generate a vibration signal sent to a piezoelectric device). This produces pharmaceutical aerosols that allow specific tissues of the patient to effectively absorb the pharmaceutical particles.

[0048] Please refer to Figure 1 , Figure 1 This is a schematic diagram of the nebulizer according to an embodiment of the present invention. The nebulizer 10, which adaptively generates drug aerosols 20 of different particle sizes, considers multiple factors to generate one or more drug aerosols 20 of different particle sizes to treat the patient 30. Typically, these multiple factors can be sensed by the sensor module 12 of the nebulizer 10, or acquired through other means, such as wireless or wired connection to other auxiliary information sources to obtain auxiliary information as factors to be considered. Additionally, the nozzle 11 of the nebulizer 10 (disposed on the outer surface of the liquid container CT of the nebulizer 10; see [link to liquid container CT]) Figure 2 The nebulizer 10 can generate a drug aerosol 20 and spray it into the upper respiratory tract of the patient 30, so that the patient 30 can inhale the drug aerosol 20 and the tissues of the upper or lower respiratory tract, such as the lungs 31 of the patient 30, can absorb the drug particles in the drug aerosol 20, thereby providing specific and precise treatment to the patient 30.

[0049] Furthermore, the atomizer 10 can dynamically generate multiple drug aerosols 20 with different particle sizes at different times based on at least one factor. It can also generate multiple drug aerosols 20 with different particle sizes at the same time, and then generate multiple drug aerosols 20 with different particle sizes at another time, with the particle size distribution of the multiple drug aerosols 20 at the two times not being the same. For example, at the first time, 50% of the drug aerosols 20 have a particle size of A and 50% have a particle size of B, and at the second time, 25% of the drug aerosols 20 have a particle size of A, 25% have a particle size of B, and 50% have a particle size of C. The particle size of the aforementioned drug aerosols 20 can refer to the median diameter of the aerodynamic mass, but this invention is not limited to this. In other embodiments, the particle size may also refer to the mean diameter of the aerodynamic mass.

[0050] Please refer to the following: Figure 2 , Figure 2 This is a functional block diagram of an atomizer according to an embodiment of the present invention. The atomizer 10 includes, in addition to... Figure 1 In addition to the sensor module 12 and nozzle 11, the atomizer 10 further includes a waveform pattern determination module 13, a data transmission interface DI, a high-frequency oscillation circuit 15, an AC / DC converter 16, a power amplifier 17, a signal modulation module 14, a piezoelectric device 18, a liquid container CT, and a porous screen 19 (illustrated in...). Figure 3 Not drawn in Figure 2 The waveform pattern determination module 13 is electrically connected to the sensor module 12, the data transmission interface DI is electrically connected to the waveform pattern determination module 13, the signal modulation module 14 is electrically connected to the waveform pattern determination module 13 and the high-frequency oscillation circuit 15, the AC / DC converter 16 is electrically connected to the high-frequency oscillation circuit 15, and the piezoelectric device 18 is electrically connected to the signal modulation module 14 through the power amplifier 17. The porous screen 19 is physically connected to the piezoelectric device 18, and the porous screen 19 and the piezoelectric device 18 are disposed within the liquid container CT.

[0051] The sensor module 12 is used to sense the patient's physical state, including respiratory status. The sensor module 12 may be, for example, a microphone module, but this invention is not limited thereto; by sensing the patient's breathing sounds through the microphone module, the patient's physical state can be obtained. The sensor module 12 may further include other types of sensors to sense at least one of the patient's facial expressions, heart rate, blood pressure, blood sugar, and body temperature, as well as the temperature of the user's environment. Correspondingly, the sensor module 12 may further include at least one of a camera, heart rate monitor, pacemaker, blood pressure monitor, blood glucose meter, thermometer, hygrometer, and ambient temperature sensor. The data transmission interface DI is used to acquire auxiliary information, including at least one of medication type and disease type. The data transmission interface DI may be a wired or wireless communication module, and its own signal is connected to an external auxiliary information source.

[0052] The waveform pattern determination module 13 generates modulation control signals based on the patient's physical condition and auxiliary information. That is, it determines the particle size or particle size distribution of the drug aerosol to be generated based on various factors. Simply put, the waveform pattern determination module 13 relies on various data (even large datasets) to determine how to generate a vibration signal with a specific waveform pattern to the piezoelectric device 18, causing the piezoelectric device 18 to vibrate and generate drug aerosols with a corresponding particle size (e.g., varying between 0.1 micrometers and 10 micrometers) or particle size distribution for precise patient treatment. The modulation control signal can be one or a combination of square waves, triangle waves, and sine waves (i.e., arbitrary waveforms), and is typically a low-frequency signal, such as a low-frequency signal between 0.05 Hz and 10 Hz, but this is not a limitation of the invention. In one embodiment, the data transmission interface DI can be removed, and the waveform pattern determination module 13 generates modulation control signals only based on the patient's physical condition.

[0053] The AC / DC converter 16 converts the AC input voltage to a DC input voltage to provide a high-frequency oscillation signal, such as a 100 kHz sine wave signal, to the high-frequency oscillation circuit 15, which generates the signal at a frequency corresponding to the DC input voltage. The AC / DC converter 16 can be any type of bridge rectifier circuit, and the invention is not limited thereto. Alternatively, in other embodiments, the DC input voltage can be directly input, and the AC / DC converter 16 can be removed.

[0054] The signal modulation module 14 is used to modulate a high-frequency oscillating signal using a modulation control signal to generate a vibration signal for the piezoelectric device 18. In one embodiment, the signal modulation module 14 may be an electronic switch that allows the high-frequency oscillating signal to generate a vibration signal based on the modulation control signal. In another embodiment, the signal modulation module 14 includes a mixer and a filter module. The mixer is electrically connected to the high-frequency oscillation circuit 15 and the waveform pattern determination module 13, and the filter module is electrically connected to the mixer and, through the power amplifier 17, to the piezoelectric device 18. The mixer is used to mix the modulation control signal and the high-frequency oscillating signal to generate a mixed signal. The filter module is used to perform intermediate frequency filtering on the mixed signal to generate a vibration signal. The signal modulation module 14 can perform modulation in many ways. Although the above modulation method is described using intensity modulation as an example, the modulation method can be one or a combination of intensity modulation, phase modulation, and frequency modulation, and the present invention is not limited thereto.

[0055] The power amplifier 17 amplifies the vibration signal and outputs the amplified vibration signal to the piezoelectric device 18. In one embodiment, if the vibration signal is not significantly affected by noise and the power of the vibration signal is sufficient to vibrate the piezoelectric device 18, the power amplifier 17 can be removed. The power amplifier 17 can be, for example, a low noise amplifier or other types of amplifiers, and the invention is not limited thereto.

[0056] In addition, please continue to refer to the following: Figure 1 and Figure 2 The nebulizer 10 may also be equipped with a manual switch P. The manual switch P is electrically connected to a waveform pattern determination module 13, which is located on the surface of the nebulizer 10 housing. It is used to generate a switching signal based on the operation of the manual switch P by the patient 30 or an operator (e.g., a nurse or physician) (e.g., pressing once, pressing for several seconds, pressing rapidly several times, etc.). The waveform pattern determination module 13 further generates a modulation control signal based on the switching signal. Thus, in addition to automatically changing the particle size of the drug aerosol 20 according to the patient 30's physical condition, the nebulizer 10 can also manually change the particle size of the drug aerosol 20 by operating the manual switch P. Preferably, in this embodiment of the invention, the switching signal has a higher priority than the physical condition; that is, when the nebulizer 10 receives a switching signal, it does not consider the patient 30's physical condition but determines the particle size of the drug aerosol 20 based on the switching signal. However, this invention is not limited to this.

[0057] Please refer to the following at the same time Figure 2 and Figure 4A liquid container CT is used to contain the pharmaceutical liquid 40. The piezoelectric device 18 includes, for example, multiple piezoelectric elements, with a porous screen 19 disposed between any two adjacent piezoelectric elements. The piezoelectric device 18 is used to generate vibration according to a vibration signal. The porous screen 19 is used to compress the pharmaceutical liquid 40 through multiple holes 191 of the porous screen 19 according to the vibration of the piezoelectric device 18 to generate multiple pharmaceutical aerosols 20 with particle sizes corresponding to a modulation control signal. Additionally, Figure 1 The nozzle 11 is disposed on the outer surface of the liquid container CT and is disposed corresponding to a plurality of holes 191 to spray out a plurality of aerosol 20.

[0058] Please note that, assuming the modulation control signal used is a square wave signal, the signal modulation module 14 is implemented with an electronic switch, and the high-frequency oscillation signal is a 100 kHz sine wave signal, then when the duration of both the logic high and logic low levels of the square wave signal is 1.5 seconds, the median aerodynamic mass diameter of the generated drug aerogel is 3.5 micrometers. Furthermore, when the duration of both the logic high and logic low levels of the square wave signal is 1.5 seconds and 3.0 seconds respectively, the median aerodynamic mass diameter of the generated drug aerogel is 1.85 micrometers. In short, by considering various factors to find the modulation control signal corresponding to the particle size of the drug aerogel suitable for the specific tissues of the patient to absorb, the goal of precision treatment can be achieved.

[0059] Please refer to the following: Figure 3 , Figure 3 This is a functional block diagram of the waveform pattern determination module according to an embodiment of the present invention. In one embodiment of the present invention, the waveform pattern determination module 13 includes a signal processing module 131, a core computing module 132, and a modulation control signal generation module 133. The signal processing module 131 is electrically connected to the sensor module 12, the core computing module 132 is electrically connected to the signal processing module 131, and the modulation control signal generation module 133 is electrically connected to the core computing module 132 and the signal modulation module 14.

[0060] Signal processing module 131 is used to perform noise filtering on the sensing signal of body state, and in one embodiment, signal processing module 131 may be a non-essential component. Core computing module 132 is used to calculate a waveform pattern based on the noise-filtered sensing signal, the waveform pattern corresponding to the particle size or particle size distribution of a predetermined pharmaceutical aerosol. Modulation control signal generation module 133 generates a modulation control signal based on the calculated waveform pattern. In this embodiment, core computing module 132 includes a neural network-based classifier to calculate the waveform pattern based on the noise-filtered sensing signal. In other embodiments, core computing module 132 may be other types of classifiers or a core computing module executing other specific algorithms.

[0061] Please refer to the following at the same time Figure 2 , Figure 4 and Figure 5 , Figure 5 This is a schematic flowchart of the nebulization method according to an embodiment of the present invention. The nebulization method for adaptively generating drug aerosols of different particle sizes includes steps S51 to S54. In step S51, a sensor module 12 is used to sense the patient's physical state, including respiratory state. In step S52, a waveform pattern determination module 13 is used to generate a modulation control signal based on the physical state. In one embodiment, the nebulization method further includes a step of acquiring auxiliary information, and step S52 can be modified to generate a modulation control signal based on the physical state and auxiliary information.

[0062] In step S53, a high-frequency oscillation signal is provided using a high-frequency oscillation circuit 15, and the high-frequency oscillation signal is modulated using a signal modulation module 14 with a modulation control signal to generate a vibration signal. In step S54, a piezoelectric device 18 generates vibration according to the vibration signal, causing a porous screen 19 to squeeze the liquid drug 40 through multiple holes 191 of the porous screen 19 to generate multiple drug aerosols 20 with particle sizes corresponding to the modulation control signal.

[0063] In summary, considering different patients' physical conditions, different diseases, different medications, and different humidity or temperature factors, the nebulizer and nebulization method of this invention can dynamically generate drug aerosols of different particle sizes, thereby achieving the purpose of precise treatment.

Claims

1. A nebulizer for adaptively generating a medicament aerosol of different particle sizes, characterized by, include: A sensor module for sensing the patient’s physical condition, including respiratory status; The waveform pattern determination module is electrically connected to the sensor module and is used to generate a modulation control signal with a frequency of 0.05 Hz to 10 Hz according to the body state. A high-frequency oscillation circuit is used to provide a high-frequency oscillation signal with a frequency of 100 kHz. A signal modulation module is electrically connected to the waveform pattern determination module and the high-frequency oscillation circuit, and is used to modulate the high-frequency oscillation signal using the modulation control signal to generate a vibration signal; A piezoelectric device, electrically connected to the signal modulation module, is used to generate vibration according to the vibration signal; as well as A porous screen, physically connected to the piezoelectric device, is used to squeeze liquid medication through multiple holes in the porous screen according to the vibration of the piezoelectric device to generate multiple drug aerosols with particle sizes corresponding to the modulation control signal. The average particle size of the drug aerosols changes with the frequency of the modulation control signal, and the signal modulation module continuously modulates the high-frequency oscillation signal through the modulation control signal, so that the particle size of the generated drug aerosols dynamically changes with the patient's respiratory state.

2. The atomizer for adaptively generating drug aerosols of different particle sizes as described in claim 1, characterized in that, Including: The data transmission interface is electrically connected to the waveform pattern determining module, which is used to acquire auxiliary information; The signal modulation module generates the modulation control signal based on the auxiliary information and the physical state, wherein the auxiliary information includes at least one of drug type and disease type, and the physical state further includes at least one of the patient's facial expression, heart rate, heart rhythm, blood pressure, blood sugar and body temperature.

3. The atomizer for adaptively generating drug aerosols of different particle sizes as described in claim 1, characterized in that, Including: A manual switch, electrically connected to the waveform pattern determination module, is used to generate a switching signal based on the operation of the manual switch by the patient or operator, wherein the waveform pattern determination module further generates the modulation control signal based on the switching signal.

4. The nebulizer of claim 1, wherein the nebulizer is configured to produce the medicament aerosol having different particle sizes in response to the change in the electrical signal. Including: An AC / DC converter, electrically connected to the high-frequency oscillation circuit, is used to convert an AC input voltage into a DC input voltage, so as to provide the high-frequency oscillation circuit with a frequency corresponding to the DC input voltage. as well as A power amplifier is electrically connected between the piezoelectric device and the signal modulation module, used to amplify the vibration signal and output the amplified vibration signal to the piezoelectric device.

5. The nebulizer of claim 1, wherein the nebulizer is configured to produce a drug aerosol having a particle size distribution that is different from a particle size distribution of a drug aerosol produced by the nebulizer when the nebulizer is operated in the second mode. The waveform pattern determination module includes: A signal processing module, electrically connected to the sensor module, is used to perform noise filtering on the sensing signals of the body state. The core computing module is electrically connected to the signal processing module and is used to calculate the waveform pattern based on the sensing signal after noise filtering. A modulation control signal generation module is electrically connected to the core computing module and the signal modulation module, and generates the modulation control signal according to the calculated waveform pattern.

6. The nebulizer of claim 5, wherein the controller is configured to control the flow rate of the pressurized gas to produce the medicament aerosol having a desired particle size distribution. The core computing module includes a neural network-based classifier to calculate the waveform pattern based on the noise-filtered sensing signal.

7. The nebulizer of claim 1, wherein the nebulizer is configured to produce a drug aerosol having a particle size distribution that is different at different times. The sensor module mentioned above includes a microphone module.

8. The atomizer for adaptively generating drug aerosols of different particle sizes as described in claim 1, characterized in that, Including: A liquid container for containing the liquid pharmaceutical agent; A nozzle is disposed on the outer surface of the liquid container and is configured corresponding to the plurality of holes to spray out the plurality of pharmaceutical aerosols.

9. The atomizer of claim 1, wherein the atomizer is configured to produce a drug aerosol having a plurality of different particle sizes. The signal modulation module mentioned above includes: A mixer, electrically connected to the high-frequency oscillation circuit and the waveform pattern determination module, is used to mix the modulation control signal and the high-frequency oscillation signal to generate a mixed signal. A filtering module, electrically connected to the mixer and the piezoelectric device, is used to perform intermediate frequency filtering on the mixed signal to generate the vibration signal.

10. The nebulizer of claim 1, wherein the nebulizer is configured to produce a drug aerosol having a particle size distribution that is different from a particle size distribution of a drug aerosol produced by a nebulizer of a different type. The modulation control signal is one or a combination of square wave, triangle wave and sine wave.

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