Biological laboratory with pathogen nucleic acid aerosol air purification system

Abstract

A biological laboratory with a pathogen nucleic acid aerosol air purification system comprises a biological laboratory, two pathogen nucleic acid aerosol purification devices are arranged in the biological laboratory, each pathogen nucleic acid aerosol purification device comprises a casing, the casing comprises a frame, a front panel, a left side plate, a right side plate, a rear baffle and a top cover plate are arranged on the frame, the front panel is an arc-shaped plate which is gradually bent forward from bottom to top, and the plate surface of the rear baffle is located in the left-right vertical direction. The purpose is to provide a biological laboratory with a pathogen nucleic acid aerosol air purification system, which can make the air in the biological laboratory circulate without dead angle, make the air circulation as vortex-free and cross-interference-free as possible, complete high-efficiency disinfection and removal of nucleic acid fragments, viruses and bacterial microorganisms in the aerosol in the air in the biological laboratory in a very short time, and complete high-efficiency removal of suspended particulate matters in the air in the biological laboratory.

Description

TECHNICAL FIELD

[0001] The present application relates to a biological laboratory with a pathogen nucleic acid aerosol air purification system. BACKGROUND

[0002] Aerosol nucleic acid fragments are generated during biological assay experiments when nucleic acid samples are shaken and centrifuged. After the cover is opened, the aerosol nucleic acid fragment sample can easily diffuse into the air, and even a small amount of aerosol nucleic acid fragment diffusion can contaminate the entire laboratory. Aerosol nucleic acid fragment contamination is a common problem in laboratories. How to solve the problem of aerosol contamination in laboratories is an urgent problem in biological assay experiments and a common problem faced by the biological field at home and abroad.

[0003] Currently, all comprehensive hospitals with biological assay laboratories above the second level have nucleic acid detection capabilities, and most hospitals have established PCR laboratories. PCR laboratories are also known as gene amplification laboratories. PCR is an abbreviation for Polymerase Chain Reaction. It is a molecular biology technique used to amplify specific DNA fragments and can be considered as a special DNA replication outside the organism.

[0004] A biological safety protection level three laboratory, referred to as a P3 laboratory, P represents Physical containment. The entire laboratory is completely sealed, and the indoor pressure is negative, so that the gas inside the laboratory will not leak to the outside and cause contamination.

[0005] In China, when performing high-level biological nucleic acid detection in a P3 laboratory, strict physical isolation methods are adopted in the process to prevent aerosol nucleic acid fragment contamination. The detection is divided into reagent preparation, sample preparation, amplification, and product detection. These strategies maximize the prevention of aerosol nucleic acid fragment contamination. The air flow organization design adopts one-way air supply, but there is still a certain probability of aerosol nucleic acid fragment contamination accidents.

[0006] Biological laboratories are key units for the prevention and control of infectious diseases and the defense of biological hazards in China. Clean laboratory space and complete experimental conditions are the basis for early detection, warning, detection, and defense. Solving the problem of aerosol nucleic acid fragment contamination and building an international first-class research and technology platform are important components of building a national biological safety barrier. SUMMARY

[0007] The present application aims to provide a biological laboratory with a pathogen nucleic acid aerosol air purification system, which can fully circulate the air in the biological laboratory without dead angle, and can complete high-efficiency sterilization and removal of nucleic acid fragments, viruses and bacterial microorganisms in the aerosol in the air in the biological laboratory in a very short time, and can complete high-efficiency removal of suspended particulate matters in the air in the biological laboratory.

[0008] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application comprises a biological laboratory, and two pathogen nucleic acid aerosol purification devices are arranged in the biological laboratory.

[0009] The bottom of the machine shell is an air inlet, and the front panel, the left side plate, the right side plate, the back plate and the top cover plate form an air duct through which air can flow from bottom to top.

[0010] A deodorizing filter screen is arranged below the centrifugal fan in the air duct along the horizontal direction, a microporous filter membrane made of H14 high-efficiency filter material is arranged below the deodorizing filter screen in the air duct along the horizontal direction, and an air electrostatic disinfection and purification module is arranged below the microporous filter membrane in the air duct along the horizontal direction.

[0011] The upper part of one wall in the biological laboratory is suspended and fixed with a pathogen nucleic acid aerosol purification device, the back plate of the pathogen nucleic acid aerosol purification device is attached to the corresponding wall, the air inlet of the pathogen nucleic acid aerosol purification device is arranged towards the ground in the biological laboratory, and the top cover plate of the pathogen nucleic acid aerosol purification device is attached to or located near the roof in the biological laboratory.

[0012] The lower part of the other wall opposite to the wall fixed with the pathogen nucleic acid aerosol purification device in the biological laboratory is provided with a pathogen nucleic acid aerosol purification device, the back baffle of the pathogen nucleic acid aerosol purification device is attached to the corresponding wall, the air inlet of the pathogen nucleic acid aerosol purification device is arranged towards the roof in the biological laboratory, and the top cover plate of the pathogen nucleic acid aerosol purification device is attached to or near the ground in the biological laboratory.

[0013] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the bottom end or the side edge of the front panel is connected to the frame mounting through a hinge, the upper part of the front panel is connected to the frame or the left side plate or the right side plate mounting through a screw or a door bolt, and an air-tight sealing strip is arranged at the edge of the front panel.

[0014] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the upper part of the west side of the north wall in the biological laboratory is hung and fixed with a pathogen nucleic acid aerosol purification device, and the lower part of the east side of the south wall in the biological laboratory is fixed with a pathogen nucleic acid aerosol purification device.

[0015] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the number of centrifugal fans is 3-5, the centrifugal fan is an adjustable air volume fan, the height of the casing along the vertical direction is 1500mm-1700mm, the width of the casing along the left-right horizontal direction is 1400mm-1900mm, the width of the top of the casing along the front-back direction is 600mm-800mm, and the width of the bottom of the casing along the front-back direction is 300mm-500mm.

[0016] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the height between the ground and the roof in the biological laboratory is 2500mm-2700mm, and the ground area in the biological laboratory is 30-50 square meters.

[0017] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein a plurality of ultraviolet lamp tubes for sterilization are arranged on the front surface of the back baffle.

[0018] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the air electrostatic disinfection and purification module comprises a plurality of foam metal plates with plate surfaces through which air flows, the plate surfaces of the foam metal plates are arranged along the front-back vertical direction, air flow channels are arranged between the foam metal plates, a row of discharge electrodes is arranged in the middle of the air flow channels along the front-back horizontal direction, the plurality of foam metal plates and the discharge electrodes are respectively mounted on an air electrostatic disinfection and purification module frame, and the air electrostatic disinfection and purification module frame is inserted into the air duct in a clearance fit.

[0019] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the thickness of the foam metal plate is 5mm-15mm.

[0020] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein the number of holes per inch PPI of the foam metal plate is 80-120, the porosity is 98%, and the bulk density of the foam metal plate is 0.1g / cm 3 , and the through-hole rate is not more than 98%.

[0021] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application, wherein a coarse filter screen is arranged at the air inlet of the bottom of the cabinet to remove various large-volume sundries first, then the airflow enters the air electrostatic disinfection and purification module, where the microorganisms are disinfected and captured by high-voltage electric field, and then the residual disinfected microorganism nucleic acid fragments are further captured by the microporous filter membrane made of H14 high-efficiency filter material to ensure the final purification effect, and the ozone removal filter screen is used to remove ozone in the airflow; a plurality of centrifugal fans are arranged in parallel along the left-right horizontal direction at intervals in the upper part of the air duct, the air inlets of the centrifugal fans are respectively located in the air duct, the air outlets of the centrifugal fans are respectively communicated with the air inlets of the arc-shaped jet pipes, the arc-shaped jet pipes are arranged along the front-back direction, the cross section of the arc-shaped jet pipes along the left-right vertical direction is rectangular, the air outlet ends of the arc-shaped jet pipes are respectively fixedly connected with the upper part of the front panel, and each arc-shaped jet pipe is in the shape of a curved arc with the air inlet end lower than the air outlet end. Due to the arc-shaped design of the arc-shaped jet pipes at the air outlet and the arc-shaped front panel which is gradually bent forward from bottom to top, the design can produce better wall attachment effect of fluid and can drive the air around the front panel to flow with the air ejected from the air outlet, so that the air flow in the biological laboratory is strengthened and disinfection dead angles are avoided. Therefore, the biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application has the characteristics that the air in the biological laboratory can be fully circulated without dead angles, the air circulation is as vortex-free and cross disturbance-free as possible, the nucleic acid fragments, viruses and bacterial microorganisms in the aerosol in the air of the biological laboratory can be disinfected and removed with high efficiency in a very short time, and the suspended particulate matters in the air of the biological laboratory can be removed with high efficiency.

[0022] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application will be further described in detail below with reference to the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is a front view of the structural schematic diagram of the biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application;

[0024] Figure 2 is a side sectional view of the air purification system of the present application; Figure 1

[0025] Figure 3 is a plan view of the air purification system of the present application; Figure 1

[0026] Figure 4 is an enlarged front view of the foam metal plate portion of the air electrostatic disinfection and purification module of the biological laboratory of the present application having the pathogen nucleic acid aerosol air purification system;

[0027] Figure 5 is a front view of the biological laboratory portion of the biological laboratory of the present application having the pathogen nucleic acid aerosol air purification system;

[0028] Figure 6 is a plan view of the air purification system of the present application; Figure 5 DETAILED DESCRIPTION

[0029] As shown in Figs. Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 , the biological laboratory of the present application having the pathogen nucleic acid aerosol air purification system comprises a biological laboratory 20, and two pathogen nucleic acid aerosol purification devices 1 are arranged in the biological laboratory 20, each of the pathogen nucleic acid aerosol purification devices 1 comprises a casing, the casing comprises a frame, and a front panel 2, a left side plate 3, a right side plate 4, a back baffle 5 and a top cover plate 6 are arranged on the frame, the front panel 2 is an arc-shaped panel which is gradually bent forward from bottom to top, the back baffle 5 and the top cover plate 6 are rectangular, the panel surface of the back baffle 5 is in the vertical direction, and the panel surface of the top cover plate 6 is in the horizontal direction;

[0030] The bottom of the casing is an air inlet, and the front panel 2, the left side plate 3, the right side plate 4, the back baffle 5 and the top cover plate 6 form an air duct 7 through which air can flow from bottom to top, a plurality of centrifugal fans 10 are arranged in the air duct 7 in parallel along the horizontal direction, the air inlets of the centrifugal fans 10 are respectively arranged in the air duct 7, the air outlets of the centrifugal fans 10 are respectively connected to the air inlets of arc-shaped jet pipes 15, the arc-shaped jet pipes 15 are arranged along the front-back direction, the cross section of the arc-shaped jet pipes 15 along the vertical direction is rectangular, the air outlets of the arc-shaped jet pipes 15 are respectively fixed to the upper portion of the front panel 2, and each of the arc-shaped jet pipes 15 is in a curved arc shape with the air inlet lower than the air outlet;

[0031] ​​​The wind channel 7 is provided with an ozone removal filter screen 11 below the centrifugal fan 10 along the horizontal direction, and is provided with a microporous filter film 12 made of H14 grade high-efficiency filter material below the ozone removal filter screen 11 along the horizontal direction, and is provided with an air static electricity sterilization and purification module 13 below the microporous filter film 12 along the horizontal direction.

[0032] The upper part of one wall in the biological laboratory 20 is hung and fixed with a pathogen nucleic acid aerosol purification device 1, the back baffle 5 of the pathogen nucleic acid aerosol purification device 1 is attached to the corresponding wall, the air inlet of the pathogen nucleic acid aerosol purification device 1 is arranged towards the ground in the biological laboratory 20, and the top cover plate 6 of the pathogen nucleic acid aerosol purification device 1 is attached to or located near the roof in the biological laboratory 20.

[0033] The lower part of the other wall opposite to the wall fixed with a pathogen nucleic acid aerosol purification device 1 in the biological laboratory 20 is provided with a pathogen nucleic acid aerosol purification device 1, the back baffle 5 of the pathogen nucleic acid aerosol purification device 1 is attached to the corresponding wall, the air inlet of the pathogen nucleic acid aerosol purification device 1 is arranged towards the roof in the biological laboratory 20, and the top cover plate 6 of the pathogen nucleic acid aerosol purification device 1 is attached to or located near the ground in the biological laboratory 20.

[0034] As a further improvement of the present application, the bottom end or side edge of the above-mentioned front panel 2 is connected to the frame mounting through a hinge, the upper part of the front panel 2 is connected to the frame or left side plate 3 or right side plate 4 through a screw or door bolt, and the edge of the front panel 2 is provided with an air-tight sealing strip.

[0035] As a further improvement of the present application, the upper part of the west side of the north wall in the above-mentioned biological laboratory 20 is hung and fixed with a pathogen nucleic acid aerosol purification device 1, and the lower part of the east side of the south wall in the biological laboratory 20 is fixed with a pathogen nucleic acid aerosol purification device 1.

[0036] As a further improvement of the present application, the number of the above-mentioned centrifugal fan 10 is 3-5, the centrifugal fan 10 is an adjustable air volume fan, the height of the cabinet along the vertical direction is 1500mm-1700mm, the width of the cabinet along the left-right horizontal direction is 1400mm-1900mm, the width of the top of the cabinet along the front-rear direction is 600mm-800mm, and the width of the bottom of the cabinet along the front-rear direction is 300mm-500mm.

[0037] As a further improvement of the present application, the height between the ground and the roof in the biological laboratory 20 is 2500mm-2700mm, and the ground area in the biological laboratory 20 is 30-50 square meters.

[0038] As a further improvement of the present application, a plurality of ultraviolet lamps for sterilization are arranged on the front surface of the back plate 5.

[0039] As a further improvement of the present application, the air electrostatic sterilization and purification module 13 comprises a plurality of foam metal plates 16 with surfaces through which air flows, the surfaces of the foam metal plates 16 are arranged along the vertical direction from front to back, air flow channels 17 are arranged between the foam metal plates 16, a row of discharge electrodes 18 is arranged in the middle of the air flow channels 17 along the horizontal direction from front to back, the plurality of foam metal plates 16 and the discharge electrodes 18 are respectively installed on an air electrostatic sterilization and purification module frame, and the air electrostatic sterilization and purification module frame is inserted into the air duct 7 in a clearance fit.

[0040] Compared with the ordinary anode plate used in the conventional electric dust removal technology, the field strength of the ordinary anode plate is only distributed on the surface of the plate, while the porous structure of the foam metal plate 16 is distributed in three dimensions, so that the field strength is formed in a three-dimensional direction and has a thorn-like shape, the space electric field is changed to an electric field similar to that formed by a sharp tip, the local field strength is increased, and the breaking effect of the nucleic acid linkage is enhanced. Meanwhile, compared with the ordinary plate, the foam metal plate 16 has a larger dust collection area in the same volume, which is equivalent to 50 times that of the ordinary anode plate, thereby greatly improving the capturing efficiency of nucleic acid fragments, viruses and bacterial microorganisms existing in the air of the biological laboratory 20.

[0041] As a further improvement of the present application, the thickness of the foam metal plate 16 is 5mm-15mm.

[0042] As a further improvement of the present application, the number of holes per inch PPI of the foam metal plate 16 is 80-120, the porosity is 98%, and the bulk density of the foam metal plate 16 is 0.1g / cm 3 , and the through-hole rate is not greater than 98%.

[0043] The design of the biological laboratory with the pathogen nucleic acid aerosol air purification system of the present application refers to the following standards and requirements formulated by the state:

[0044] JGJ91-93 "Code for Design of Scientific Laboratory Buildings"

[0045] GB 50346-2011 "Technical Code for Biosafety Laboratory Buildings"

[0046] GB / 19489-2008 "General Requirements for Laboratory Biosafety"

[0047] GB 14925-2010 Laboratory Animal Environment and Facilities

[0048] GB / T29475-2012 "Design Principles and Basic Requirements for Mobile Laboratories"

[0049] GB / T29479-2012 General Requirements for Mobile Laboratories

[0050] National Standard for Laboratory Animal Environment and Facilities (GB 14925-2010)

[0051] According to the relevant design specifications for ventilation in safety laboratories, the air circulation volume for disinfection and purification in Biological Laboratory 20 must meet the requirement of at least 15 disinfection and purification cycles per hour. If the preset conditions for Biological Laboratory 20 are: a usable area of ​​40 square meters, a room height of 2.6 meters, and an indoor air volume of 104 cubic meters, then the minimum total air circulation volume for disinfection and purification in Biological Laboratory 20 is: 104 * 15 = 1560 m³. 3 / h.

[0052] In the design process of the biological laboratory with pathogen nucleic acid aerosol air purification system of the present invention, after multiple comprehensive comparisons of various unit placement methods and different equipment air outlet designs, it was found that the best air circulation effect was achieved when two units were placed opposite each other in biological laboratory room 20, with the air inlet and outlet of the two units designed in opposite directions and symmetrically. This can minimize the problems of severe imbalance in circulation and numerous dead zones in biological laboratory room 20 caused by traditional top-supply and top-return air fields and floor-standing air sterilizers.

[0053] The fan of the two pathogen nucleic acid aerosol purification device 1 can be designed to be 1000m. 3 / h and 600m 3 Two airflow rates are available: 1000 m³ / h. In a biological laboratory where no one is present and disinfection is required, the 1000 m³ / h rate can be used. 3 The 600 m³ / h airflow mode maximizes the number of indoor air circulations; when people and machines coexist, the 600 m³ / h airflow mode is used to keep the air in the biological laboratory 20 in a relatively stable state while disinfecting and purifying. The air purification circulation times for the 40 square meter, 2.6-meter-high biological laboratory 20 room are 19 and 12 respectively under the two airflow modes.

[0054] The air electrostatic disinfection and purification module 13 and coarse filter 14 of the pathogen nucleic acid aerosol purification device 1 can be manually cleaned, and the microporous filter membrane 12 made of H14 grade high-efficiency filter material can be replaced periodically according to the usage time.

[0055] In summary, the diagonal arrangement scheme of the two pathogen nucleic acid aerosol purification devices 1 with the reversed air inlet and outlet can make the airflow better fill the entire biological laboratory 20 without forming vortex, so as to ensure that the airflow in the biological laboratory 20 can smoothly enter the air inlet of the pathogen nucleic acid aerosol purification device 1, and when the air volume of a single pathogen nucleic acid aerosol purification device 1 is 1000 m 3 / h, more than 97% of the airflow velocity in the biological laboratory 20 is greater than 0.05 m / s.

[0056] The microorganism inactivation principle of the air electrostatic disinfection and purification module 13 of the present application is as follows.

[0057] The air electrostatic disinfection and purification module 13 of the present application inactivates microorganisms mainly through the following two aspects:

[0058] (1) The air electrostatic disinfection and purification module 13 can continuously release plasma, and the inactivation components (active groups, charged particles and electric field, etc.) in the plasma can rapidly kill microorganisms by biological damage (cell membrane damage, biological macromolecule damage and microbial sub-lethality).

[0059] (2) The air electrostatic disinfection and purification module 13 can continuously release the electric field force of the strong electric field of 30,000 volts, which can produce a polarization effect on microorganisms and nucleic acids, the active tissues of microorganisms are instantaneously broken by the strong electric field, so that the microorganisms are inactivated, and the nucleic acid sequence order is affected, further preventing the possibility of microbial amplification and replication.

[0060] (3) Kill microorganisms by plasma: the air electrostatic disinfection and purification module 13 can release a large amount of plasma by high-voltage electric field. Plasma is a conductive fluid with electrical neutrality, which is composed of electrons, ions, free radicals, excited particles, etc. Its composition is complex and diverse, and its nature is active. In addition to high-energy particles, ultraviolet rays and high-energy electric field, there are many active particles in the excited or unexcited state. When these active particles come into contact with microorganisms, a series of complex biochemical reactions and physical processes will occur between them and the biological membrane.

[0061] From a macroscopic point of view, the sterilization process of atmospheric pressure low temperature plasma is actually the interaction between the active components (such as positive and negative ions, active groups, charged particles and electric field, ultraviolet rays, etc.) produced by plasma and biological macromolecules (such as proteins, DNA, lipids, etc.), which causes changes in cell components (such as cell wall, cell membrane, cytoplasm, etc.), and then causes cell death. Plasma active components either inactivate and denature biological macromolecules in a short time, or change the oxidative stress level in the cell, so as to achieve the purpose of microorganism inactivation.

[0062] Main microorganism inactivation components of plasma

[0063] In the sterilization process of atmospheric pressure low temperature plasma, active groups, charged particles and electric field are the main factors of concern.

[0064] 1) Active groups

[0065] The mainstream theory of the sterilization mechanism of atmospheric pressure low temperature plasma at present believes that reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a major role in inducing cell death. Table 1 shows the common ROS and RNS in plasma.

[0066] Table 1 Common ROS / RNS in plasma

[0067]

[0068] 2) Charged particles and electric field

[0069] During the generation of plasma, an electric field exists between the two high-voltage electrodes, and the working gas is dissociated between the high-voltage electrodes to form many charged particles. Related studies have shown that when bacterial samples are placed in the gap of dielectric barrier discharge, plasma will transfer charged substances to the surface of bacteria, and high electric field strength will also have some impact on bacteria. Plasma can destroy the external structure of microorganisms, leading to the leakage of proteins, nucleic acids and K+ in the cytoplasm, in which charged particles and active substances play a major role.

[0070] Biological damage of plasma to microorganisms: When plasma acts on microorganisms, different tissues of microorganisms will respond differently. The mechanism of biological response generated by cells can be summarized as follows:

[0071] 1) Cell membrane damage theory

[0072] When the active substances generated by plasma act on the cell membrane, the lipids on the cell membrane are peroxidized, and the cell membrane potential is changed, the cell membrane permeability is increased, causing more plasma active ingredients from the outside to enter the cell interior, and the cell contents are leaked. At this time, the cell membrane morphology appears to collapse or defect, the normal physiological function of the cell is disordered, the cell membrane is ruptured, and thus the cell apoptosis or even death is caused.

[0073] 2) Biological macromolecule damage theory

[0074] When plasma active components act on cells, they cause oxidative damage to biological macromolecules such as proteins, nucleic acids and lipids, causing protein structure denaturation, DNA oxidative degradation and lipid peroxidation, and other complex biochemical reactions, which in turn have an important impact on the physiological function of biological tissues.

[0075] 3) Microbial sublethal theory

[0076] After the plasma treatment, the microorganism is not obviously damaged in morphology, but its metabolic capacity is weakened, growth is delayed or stopped, and metabolic enzyme activity is destroyed, eventually leading to microbial death. The cell lipid peroxidation caused by plasma may be the main factor causing the cell to be in a sublethal state.

[0077] The biological laboratory with the pathogen nucleic acid aerosol air purification system of the application is provided with a coarse filter screen 14 at the air inlet at the bottom of the cabinet, which first removes various large-volume sundries, and then the airflow enters the air electrostatic disinfection and purification module 13, where the microorganisms are disinfected and captured through a high-voltage electric field, and then the microporous filter film 12 made of H14 high-efficiency filter material is used to further capture the individual residual microorganism nucleic acid fragments that have been disinfected, to ensure the final purification effect, and the ozone removal filter screen 11 is used to remove ozone in the airflow; a plurality of centrifugal fans 10 are arranged in parallel along the left-right horizontal direction at the upper part in the air duct 7, the air inlets of each centrifugal fan 10 are located in the air duct 7 respectively, the air outlets of each centrifugal fan 10 are communicated with the air inlets of the arc-shaped jet pipe 15 respectively, the arc-shaped jet pipe 15 is arranged along the front-back direction, the cross section of the arc-shaped jet pipe 15 along the left-right vertical direction is rectangular, the air outlet ends of each arc-shaped jet pipe 15 are fixedly connected with the upper part of the front panel 2 respectively, and each arc-shaped jet pipe 15 is a curved arc-shaped pipe with the air inlet end lower than the air outlet end. Due to the arc-shaped design of the arc-shaped jet pipe 15 at the air outlet and the arc-shaped panel of the front panel 2 which is gradually bent forward from bottom to top, better wall attachment effect of fluid can be achieved, and the air around the front panel 2 can be driven to flow with the air ejected from the air outlet, so that the air flow in the entire biological laboratory 20 is strengthened, and disinfection dead angles are avoided. Therefore, the biological laboratory with the pathogen nucleic acid aerosol air purification system of the application has the characteristics that the air in the biological laboratory can be fully circulated without dead angles, the air circulation is as vortex-free and cross-interference-free as possible, the nucleic acid fragments, viruses and bacterial microorganisms in the aerosol in the air of the biological laboratory 20 are disinfected and removed with high efficiency in a very short time, and the suspended particulate matters in the air of the biological laboratory are removed with high efficiency.

Claims

1. A biological laboratory equipped with a pathogen nucleic acid aerosol air purification system, comprising a biological laboratory (20), characterized in that: The biological laboratory (20) is equipped with two pathogen nucleic acid aerosol purification devices (1). Each pathogen nucleic acid aerosol purification device (1) includes a housing, which includes a frame. The frame is equipped with a front panel (2), a left side panel (3), a right side panel (4), a rear baffle (5), and a top cover (6). The front panel (2) is an arc-shaped panel that gradually bends forward from bottom to top. The rear baffle (5) and the top cover (6) are rectangular. The surface of the rear baffle (5) is located in the left and right vertical direction, and the surface of the top cover (6) is located in the horizontal direction. The bottom of the casing is an air inlet (8). The front panel (2), left side panel (3), right side panel (4), rear baffle (5) and top cover (6) form an air duct (7) that allows air to flow from bottom to top. Multiple centrifugal fans (10) are arranged side by side in the upper part of the air duct (7) along the horizontal direction. The air inlet of each centrifugal fan (10) is located in the air duct (7). The air outlet of each centrifugal fan (10) is connected to the air inlet of the arc-shaped jet pipe (15). The arc-shaped jet pipe (15) is arranged along the front and back direction. The cross section of the arc-shaped jet pipe (15) along the vertical direction is rectangular. The air outlet end of each arc-shaped jet pipe (15) is fixedly connected to the upper part of the front panel (2). Each arc-shaped jet pipe (15) is a curved arc with a low air inlet end and a high air outlet end. An ozone deodorization filter (11) is provided horizontally below the centrifugal fan (10) in the air duct (7). A microporous filter membrane (12) made of H14 grade high-efficiency filter material is provided horizontally below the ozone deodorization filter (11) in the air duct (7). An air electrostatic disinfection and purification module (13) is provided horizontally below the microporous filter membrane (12) in the air duct (7). A coarse filter (14) is provided at the air inlet (8) at the bottom of the housing. A pathogen nucleic acid aerosol purification device (1) is suspended and fixed on the upper part of one wall in the biological laboratory (20). The rear baffle (5) of the pathogen nucleic acid aerosol purification device (1) is attached to the corresponding wall. The air inlet of the pathogen nucleic acid aerosol purification device (1) is arranged facing the ground in the biological laboratory (20). The top cover (6) of the pathogen nucleic acid aerosol purification device (1) is attached to the roof in the biological laboratory (20) or located near the roof in the biological laboratory (20). Inside the biological laboratory (20), a pathogen nucleic acid aerosol purification device (1) is provided on the lower part of another wall opposite to the wall on which a pathogen nucleic acid aerosol purification device (1) is fixed. The rear baffle (5) of the pathogen nucleic acid aerosol purification device (1) is attached to the corresponding wall. The air inlet of the pathogen nucleic acid aerosol purification device (1) is arranged facing the roof inside the biological laboratory (20). The top cover (6) of the pathogen nucleic acid aerosol purification device (1) is attached to the ground inside the biological laboratory (20) or located near the ground inside the biological laboratory (20). The rear baffle (5) has multiple ultraviolet lamps for sterilization on its front-facing surface. The air electrostatic disinfection and purification module (13) includes multiple foam metal plates (16) with airflow passing through their surfaces. The surfaces of the foam metal plates (16) are arranged in a vertical direction along the front and back, and airflow channels (17) are provided between the foam metal plates (16).

2. The biological laboratory with a pathogen nucleic acid aerosol air purification system according to claim 1, characterized in that: The bottom or side of the front panel (2) is connected to the frame by hinges, and the upper part of the front panel (2) is connected to the frame, the left side panel (3) or the right side panel (4) by screws or door latches. An airtight strip is provided at the edge of the front panel (2).

3. The biological laboratory with a pathogen nucleic acid aerosol air purification system according to claim 2, characterized in that: A pathogen nucleic acid aerosol purification device (1) is suspended and fixed on the upper part of the west side of the north wall inside the biological laboratory (20), and a pathogen nucleic acid aerosol purification device (1) is fixed on the lower part of the east side of the south wall inside the biological laboratory (20).

4. The biological laboratory with a pathogen nucleic acid aerosol air purification system according to claim 3, characterized in that: The number of centrifugal fans (10) is 3-5. The centrifugal fans (10) are adjustable air volume fans. The height of the casing along the vertical direction is 1500mm-1700mm, the width of the casing along the horizontal direction is 1400mm-1900mm, the width of the top of the casing along the front-back direction is 600mm-800mm, and the width of the bottom of the casing along the front-back direction is 300mm-500mm.

5. The biological laboratory with a pathogen nucleic acid aerosol air purification system according to claim 4, characterized in that: The height from the ground to the roof in the biological laboratory (20) is 2500mm-2700mm, and the ground area in the biological laboratory (20) is 30-50 square meters.

6. A biological laboratory with a pathogen nucleic acid aerosol air purification system according to any one of claims 1 to 5, characterized in that: A discharge electrode (18) is provided in the middle of the airflow channel (17) along the front and rear horizontal direction. Multiple foam metal plates (16) and discharge electrodes (18) are respectively installed on the air electrostatic disinfection and purification module frame. The air electrostatic disinfection and purification module frame is inserted into the air duct (7) with a gap fit.

7. The biological laboratory with a pathogen nucleic acid aerosol air purification system according to claim 6, characterized in that: The thickness of the foam metal plate (16) is 5mm-15mm.

8. The biological laboratory with a pathogen nucleic acid aerosol air purification system according to claim 7, characterized in that: The foamed metal board (16) has a pore size ratio (PPI) of 80-120 per inch, a porosity of 98%, and a bulk density of 0.1 g / cm³. 3 The porosity is no more than 98%.

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