Blood purification apparatus and storage medium

Abstract

The application discloses a blood purification device and a storage medium. The device comprises a memory and a processor. The memory stores a computer program. The processor executes the computer program and realizes the following method: when entering a blood purification treatment stage, a first peristaltic pump is controlled to start rotating at a first theoretical rotating speed, which is obtained according to total liquid supplementing volume and total blood purification time length; every preset period, a theoretical weight reduction amount of a replacement fluid bag is determined according to the first theoretical rotating speed, and an actual weight reduction amount of the replacement fluid bag is detected by using a first weighing scale; when an absolute value of a first difference between the theoretical weight reduction amount and the actual weight reduction amount is greater than a first preset weight and less than or equal to a second preset weight, the rotating speed of the first peristaltic pump is feedback adjusted according to the first difference. In this way, the deviation degree between the actual liquid supplementing amount and the user's expected liquid supplementing amount in the liquid supplementing step can be reduced, and the blood purification treatment safety of the patient is improved.

Description

Technical Field

[0001] This application relates to the field of blood purification technology, and more particularly to a blood purification device and storage medium. Background Technology

[0002] In the treatment process of blood purification equipment, the step of removing waste fluid from the patient's blood is called the waste fluid removal step, and the step of replenishing the purified blood with replacement fluid is called the fluid replacement step. Both the waste fluid removal and fluid replacement steps need to maintain fluid balance during blood purification treatment, requiring adaptive adjustment of the total amount of replacement fluid in the fluid replacement step. However, during blood purification treatment, the fluid replacement rate is a user's expected value. The actual output rate of replacement fluid in the fluid replacement step is affected by many practical factors, leading to a significant deviation between the fluid replacement rate and the actual output rate. This deviation not only causes fluid imbalance during blood purification treatment, reducing the patient's blood purification effect, but also, in cases of significant deviation, can compromise the safety of the blood purification treatment and even lead to medical accidents. Therefore, the applicability of blood purification equipment is greatly limited. Summary of the Invention

[0003] Based on this, this application provides a blood purification device and storage medium that can reduce the deviation between the actual fluid replacement volume and the user's expected fluid replacement volume during the fluid replacement step, improve the safety of blood purification treatment for patients, and broaden the applicability of the blood purification device.

[0004] In a first aspect, this application provides a blood purification device, comprising: a first weighing scale, a first peristaltic pump, a replacement fluid bag, a rehydration branch, and a blood circuit; the blood circuit is used to transport blood, the replacement fluid bag is used to store replacement fluid, the first weighing scale is used to detect the weight of the replacement fluid bag, one end of the rehydration branch is connected to the blood circuit, the other end of the rehydration branch is connected to the replacement fluid bag, and the rehydration branch is disposed on the first peristaltic pump; the blood purifier further comprises: a memory and a processor, the memory being used to store a computer program, and the processor being used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device:

[0005] When the blood purification device enters the blood purification treatment stage, the first peristaltic pump is controlled to start rotating at a first theoretical speed. The first theoretical speed is calculated based on the preset total fluid resuscitation volume and the preset total blood purification time. The first theoretical speed is equal to the total fluid resuscitation volume divided by the total blood purification time.

[0006] Every preset period, the theoretical weight reduction of the replacement fluid bag is determined based on the first theoretical rotation speed, and the actual weight reduction of the replacement fluid bag is detected using the first weighing scale.

[0007] When the absolute value of the first difference between the theoretical weight reduction and the actual weight reduction is greater than the first preset weight and less than or equal to the second preset weight, the rotational speed of the first peristaltic pump is adjusted based on the first difference.

[0008] Secondly, this application provides a computer-readable storage medium storing a computer program that, when executed by a processor, causes the processor to implement the control method for the blood purification device as described above.

[0009] In this embodiment, the theoretical weight reduction of the replacement fluid bag represents the user's desired infusion rate, while the actual weight reduction represents the actual output rate of the replacement fluid. The rotational speed of the first peristaltic pump is adjusted based on the difference between the theoretical and actual weight reduction. This adjustment ensures that the actual output rate of the replacement fluid in the infusion branch driven by the first peristaltic pump consistently approaches the user's desired infusion rate, and the actual weight reduction of the replacement fluid bag remains within the user's acceptable error range. Therefore, the deviation between the actual infusion volume and the user's desired infusion volume during the infusion process is reduced, improving the safety of the patient's blood purification treatment and expanding the applicability of the blood purification device. Attached Figure Description

[0010] Figure 1 This is a schematic diagram illustrating the basic principle of an embodiment of the blood purification treatment method shown in this application;

[0011] Figure 2 This is a schematic diagram of the basic structure of an embodiment of the blood purification device of this application;

[0012] Figure 3 This is a schematic flowchart of an embodiment of the control method for the blood purification device of this application;

[0013] Figure 4 This is a schematic diagram showing an embodiment of the blood purification treatment interface shown in this application;

[0014] Figure 5 This is a schematic diagram of an embodiment of the actual rotational speed variation curve of the first peristaltic pump shown in this application;

[0015] Figure 6 This is a schematic diagram showing the relationship between the actual rotational speed of the first peristaltic pump and the rate of decrease in the liquid weight of the displacement fluid bag in a normal and abnormal embodiment, as illustrated in this application.

[0016] Figure 7 This is a schematic diagram of a curve representing an embodiment of the correspondence between the first theoretical rotational speed and the first preset duration shown in this application. Detailed Implementation

[0017] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0018] The flowchart shown in the attached diagram is for illustrative purposes only and does not necessarily include all content and operations / steps, nor does it necessarily have to be performed in the order described. For example, some operations / steps can be broken down, combined, or partially merged, so the actual execution order may change depending on the actual situation.

[0019] Blood purification therapy involves drawing blood from the patient's body and purifying it using specialized equipment to remove specific substances. The purified blood is then returned to the patient to achieve the goal of purifying the blood and treating the disease. Technicians need to utilize this blood purification equipment, which integrates various systems such as blood circuits, fluid circuits, monitoring systems, drive systems, anticoagulation systems, and waste fluid systems. Only through coordinated and balanced control of these systems can the patient's blood purification treatment be ensured to be safe.

[0020] Figure 1 The diagram illustrates the basic principle of blood purification treatment. During blood purification, a blood purifier removes specific substances from the patient's blood, forming waste fluid. Simultaneously, a solution containing therapeutic substances and essential nutrients is added to the purified blood, forming replacement fluid. The step of removing waste fluid from the patient's blood is called waste fluid removal, and the step of adding replacement fluid to the purified blood is called fluid replacement. Maintaining fluid balance during blood purification requires adaptive adjustment of the total amount of replacement fluid in the fluid replacement step.

[0021] However, during blood purification treatment, the fluid replacement rate is a user's expected value. The actual output rate of the replacement fluid during the fluid replacement step is affected by many practical factors, leading to a significant deviation between the fluid replacement rate and the actual output rate. This deviation not only causes fluid imbalance during blood purification treatment, reducing the patient's treatment effectiveness, but also, when the deviation between the fluid replacement rate and the actual output rate is very large, it can compromise the safety of the blood purification treatment and even lead to medical accidents. Therefore, the applicability of blood purification equipment is greatly limited.

[0022] To address the aforementioned issues, in this embodiment, the theoretical weight reduction of the replacement fluid bag represents the user's desired infusion rate, while the actual weight reduction represents the actual output rate of the replacement fluid. The rotational speed of the first peristaltic pump is adjusted based on the difference between the theoretical and actual weight reductions. This adjustment ensures that the actual output rate of the replacement fluid in the infusion branch driven by the first peristaltic pump consistently approaches the user's desired infusion rate, and the actual weight reduction of the replacement fluid bag remains within the user's acceptable error range. Therefore, the deviation between the actual infusion volume and the user's desired infusion volume during the infusion process is reduced, improving the safety of the patient's blood purification treatment and broadening the applicability of the blood purification device.

[0023] The blood purification device according to embodiments of this application will now be described in detail with reference to the accompanying drawings.

[0024] To better illustrate the specific implementation methods of the embodiments of this application, Figure 2 The basic structure of the blood purification equipment is shown in the diagram; combined with Figure 1 and Figure 2The blood purification device includes: a display screen, a first weighing scale, a first peristaltic pump, a replacement fluid bag, a rehydration branch, and a blood circuit; the blood circuit is used to transport blood, the replacement fluid bag is used to store a certain volume of replacement fluid, the first weighing scale is used to detect the weight of the replacement fluid bag, one end of the rehydration branch is connected to the blood circuit, the other end of the rehydration branch is connected to the replacement fluid bag, and the rehydration branch is mounted on the first peristaltic pump; the blood circuit includes: an arterial line and a venous line, the arterial line outputs arterial blood to the blood purifier, the blood purifier purifies the arterial blood, and the venous line outputs the purified blood to the veins of the body; Replacement fluid bags are medical fluid storage bags. Before the blood purification treatment begins, the replacement fluid bag stores a certain volume of replacement fluid, for example, 2500g of pre-stored replacement fluid. The replacement fluid is customized according to the patient's clinical treatment needs, including therapeutic substances and beneficial nutrients. During the blood purification treatment, the rehydration circuit outputs the replacement fluid to the blood circuit, which then returns the replacement fluid and purified blood to the body. The first peristaltic pump provides driving force to the rehydration circuit to regulate the flow rate and direction of the replacement fluid, enabling the rehydration process of the blood purification equipment.

[0025] It should be noted that the first peristaltic pump is a common electronic component. The control principle of the first peristaltic pump is as follows: when the replenishment branch is installed in the first peristaltic pump, the negative pressure generated by the operation of the first peristaltic pump draws the replacement fluid from the replacement fluid bag. The first peristaltic pump alternately squeezes and releases the pump tubing to pump the replacement fluid. The first peristaltic pump is a positive displacement pump. Because the liquid being transported flows slowly and in a pulsating manner, like a crawling animal moving forward, it is called a peristaltic pump. The peristaltic pump uses the method of squeezing an elastic flexible tube to push the gas or liquid inside the tube forward; it utilizes the local vacuum created when the tube recovers its elasticity to draw in the liquid or gas behind. This squeezing process is continuous, and the suction and transport of liquid or gas are constantly formed, thus achieving continuous pumping of gas or liquid.

[0026] The blood purification device further includes a memory and a processor; the memory is used to store a computer program, and the processor is used to execute the computer program and, when executing the computer program, implement the control method of the blood purification device as described below.

[0027] See Figure 3 The control method of the blood purification device in this application includes the following steps:

[0028] Step S101: When the blood purification device enters the blood purification treatment stage, the first peristaltic pump is controlled to start rotating at the first theoretical speed. The first theoretical speed is calculated based on the preset total fluid replacement volume and the preset total blood purification time. The first theoretical speed is equal to the total fluid replacement volume divided by the total blood purification time.

[0029] In this embodiment, the first theoretical rotational speed of the first peristaltic pump is calculated based on the preset total fluid refill volume and the preset total blood purification time; wherein, the first theoretical rotational speed = total fluid refill volume / total blood purification time.

[0030] Because the first peristaltic pump operates, the fluid replacement branch delivers replacement fluid to the blood circuit at a specific rate. This rate can fluctuate due to external factors. Since the total output of replacement fluid during the total blood purification time must equal the total fluid volume, a first theoretical speed of rotation for the first peristaltic pump needs to be set. This first theoretical speed represents the pump's rotation speed under theoretical conditions. Under these conditions, controlling the first peristaltic pump to rotate at this first theoretical speed ensures that the total output of replacement fluid in the fluid replacement branch during the total blood purification time is exactly equal to the total fluid volume. For example, if the total fluid volume is 1000g and the total blood purification time is 16h, the first theoretical speed = total fluid volume / total blood purification time = 1.04g / min.

[0031] When the blood purification device enters the blood purification treatment stage, the first peristaltic pump is controlled to start rotating at the first theoretical speed. The rotation of the first peristaltic pump provides driving force to the fluid replenishment branch, which connects to the replacement fluid. The fluid replenishment branch then transmits the replacement fluid to the blood circuit, through which the replacement fluid and the purified blood are returned to the body. It should be noted that while the first peristaltic pump starts rotating at the first theoretical speed at the beginning of the blood purification treatment stage, the actual speed of the first peristaltic pump will change as blood purification continues. The user can also adjust the actual speed of the first peristaltic pump, which will fluctuate to some extent. Therefore, in S101, the first peristaltic pump is controlled to start rotating at the first theoretical speed at the instant the "blood purification treatment stage" begins, rather than operating at the first theoretical speed continuously throughout the entire "blood purification treatment stage" (because the actual speed of the first peristaltic pump will actually change throughout the entire blood purification treatment stage).

[0032] Step S102: Every preset period, determine the theoretical weight reduction of the replacement fluid bag based on the first theoretical rotation speed, and use the first weighing scale to detect the actual weight reduction of the replacement fluid bag.

[0033] Step S103: When the absolute value of the first difference between the theoretical weight reduction and the actual weight reduction is greater than the first preset weight and less than or equal to the second preset weight, the rotation speed of the first peristaltic pump is adjusted according to the first difference.

[0034] During blood purification treatment, the fluid replacement branch continuously delivers replacement fluid to the blood circuit, and the weight of the replacement fluid stored in the replacement fluid bag gradually decreases. Therefore, the theoretical and actual weight reduction of the replacement fluid bag can be obtained every preset period. The preset period is a pre-defined value; for example, if the preset period is 3 seconds, then during blood purification treatment, the theoretical and actual weight reduction of the replacement fluid bag will be obtained every 3 seconds.

[0035] The theoretical weight reduction of the replacement fluid bag can be calculated using the following formula: Theoretical weight reduction of the replacement fluid bag = First theoretical rotation speed * Cumulative blood purification time; for example, if the first theoretical rotation speed is 1.04 g / min and the cumulative blood purification time is 180 min, then the theoretical weight reduction of the replacement fluid bag = First theoretical rotation speed * Cumulative blood purification time = 1.04 g / min * 180 min = 187.2 g. It is important to note the following two points: 1. In the formula for calculating the theoretical weight reduction, the first theoretical rotation speed is a fixed value. That is, the first theoretical rotation speed is the rotation speed of the first peristaltic pump under theoretical conditions, not the actual rotation speed of the first peristaltic pump. As mentioned above, the actual rotation speed of the first peristaltic pump can fluctuate. 2. In the formula for calculating the theoretical weight reduction, the cumulative blood purification time is a cumulative value, not a continuous value. For example, during the blood purification treatment phase, if the blood purification equipment performs blood purification treatment for 2 hours, then interrupts for 10 minutes, and then resumes blood purification treatment for another 2 hours, then the cumulative blood purification time is 4 hours. The theoretical weight reduction of the replacement fluid bag calculated based on the first theoretical rotation speed represents the user's expected weight reduction of the replacement fluid. If the actual weight reduction of the replacement fluid bag is equal to the theoretical weight reduction of the replacement fluid bag, then the fluid replenishment step of the replenishment branch is in the most normal state.

[0036] The actual weight reduction of the replacement fluid bag is detected using the first weighing scale. The actual weight reduction can be expressed by the following formula: Actual weight reduction of the replacement fluid bag = Initial weight of the replacement fluid bag - Actual weight of the replacement fluid bag. The initial weight of the replacement fluid bag represents its initial weight when fully filled with replacement fluid before the start of the blood purification treatment. The actual weight of the replacement fluid bag represents its weight measured at each preset cycle during the blood purification treatment. As the patient's blood purification treatment continues, the actual weight of the replacement fluid bag is measured using the first weighing scale at each preset cycle, and the actual weight of the replacement fluid bag will show a decreasing trend. For example, if the initial weight of the replacement fluid bag is 2000g, and after 4 hours of blood purification treatment, the actual weight measured by the first weighing scale is 1700g, then the actual weight reduction of the replacement fluid bag = Initial weight of the replacement fluid bag - Actual weight of the replacement fluid bag = 2000g - 1700g = 300g. The actual weight reduction of the replacement fluid bag represents the cumulative weight of replacement fluid actually output by the replacement fluid bag during the blood purification treatment.

[0037] If the first preset weight < |theoretical weight reduction - actual weight reduction| ≤ the second preset weight, then the rotational speed of the first peristaltic pump is adjusted based on the first difference between the theoretical weight reduction and the actual weight reduction. Wherein, the second preset weight is greater than the first preset weight, and both the second preset weight and the first preset weight are greater than 0.

[0038] Specifically, the first preset weight represents the user-acceptable error range, and the second preset weight represents the safe error range. These two preset weights can be empirical values ​​set in advance based on clinical experience. For example, the first preset weight is 3g and the second preset weight is 5g. If |theoretical weight reduction - actual weight reduction| ≤ the first preset weight, then the actual weight reduction of the replacement fluid bag is within the user-acceptable error range, the fluid infusion procedure of the infusion branch is in a normal state, there is no need to adjust the speed of the first peristaltic pump, and the patient's blood purification treatment stage is in a normal and safe state.

[0039] When the first preset weight <|theoretical weight reduction - actual weight reduction| ≤ the second preset weight, it indicates that the actual weight reduction of the replacement fluid bag has exceeded the user's acceptable error range, but is still within a safe error range. This means that there is a deviation between the actual output rate of the replacement fluid in the infusion branch controlled by the first peristaltic pump and the user's expected infusion rate. Based on the first difference between the theoretical weight reduction and the actual weight reduction, the rotation speed of the first peristaltic pump is adjusted. After feedback adjustment, the rotation speed of the first peristaltic pump will increase or decrease. Correspondingly, the flow rate of the replacement fluid in the infusion branch will also increase or decrease, the actual output rate of the replacement fluid in the infusion branch will also increase or decrease, and the actual weight reduction rate of the replacement fluid bag will also increase or decrease. After feedback adjustment, the actual weight reduction of the replacement fluid bag will return to the user's acceptable error range. Therefore, the embodiments of this application can realize the feedback adjustment function of the infusion step of the infusion branch, greatly ensuring the treatment safety of patients during the blood purification treatment stage.

[0040] Therefore, this embodiment monitors the actual state of the fluid replacement step in the fluid replacement branch and adjusts the speed of the first peristaltic pump based on the difference between the theoretical weight reduction and the actual weight reduction, thereby reducing the deviation between the actual weight reduction of the replacement fluid bag and the theoretical weight reduction of the replacement fluid bag, and ensuring the safety and flexibility of the fluid replacement step in the blood purification treatment stage.

[0041] In some embodiments, the method may further include:

[0042] Step S104: When the absolute value of the first difference is greater than the second preset weight, a first fault alarm signal is issued.

[0043] If the second preset weight is less than |theoretical weight reduction - actual weight reduction|, then a first fault alarm signal is issued, for example, an audible and visual fault alarm signal is issued.

[0044] When the second preset weight is less than |theoretical weight reduction - actual weight reduction|, it indicates that the actual weight reduction of the replacement fluid bag has exceeded the safe error range. The actual output rate of the replacement fluid in the infusion branch controlled by the first peristaltic pump is significantly too high or too low. In this case, there is no need to adjust the speed of the first peristaltic pump, because the replacement fluid output from the infusion branch is in a faulty state. This has caused the patient's blood purification treatment to be in an extremely unsafe state. This situation is very urgent and requires the immediate issuance of a first fault alarm signal (e.g., an audible and visual fault alarm signal). The first fault alarm signal will alert the user that the infusion step of the infusion branch is in a faulty state. When the user notices the first fault alarm signal, they will immediately address the faulty state of the infusion step. This can prevent the blood purification equipment from continuing to operate under faulty infusion steps, thus ensuring greater safety for the patient during the blood purification treatment.

[0045] It should be noted that the theoretical weight reduction and actual weight reduction of the replacement fluid bag are obtained every preset period. Based on the difference between the theoretical weight reduction and the actual weight reduction, three cases can be divided: 1. |Theoretical weight reduction - Actual weight reduction| ≤ First preset weight, normal state; 2. First preset weight < |Theoretical weight reduction - Actual weight reduction| ≤ Second preset weight, feedback adjustment state; 3. Second preset weight < |Theoretical weight reduction - Actual weight reduction|, fault state. As mentioned above, the theoretical weight reduction represents the weight reduction of the replacement fluid bag under theoretical conditions. So why does the actual weight reduction of the replacement fluid bag deviate from the theoretical weight reduction during blood purification treatment? This is related to the control performance of the first peristaltic pump itself. According to the driving principle of the peristaltic pump, the first peristaltic pump squeezes the tubing to drive the fluid flow within the tubing. Due to the long-term squeezing of the tubing by the first peristaltic pump, the tubing wall will deform and cannot recover. If the first peristaltic pump still maintains the first theoretical speed, due to the deformation of the tubing, the actual output rate of the replacement fluid driven by the first peristaltic pump in the fluid replenishment branch will increase or decrease relative to the user's expected replenishment rate. This will cause a deviation between the theoretical weight reduction and the actual weight reduction of the replacement fluid bag.

[0046] In some embodiments, step S101, before controlling the first peristaltic pump to start rotating at the first theoretical speed when the blood purification device enters the blood purification treatment stage, may further include:

[0047] Step S105: Display the blood purification treatment interface on the screen of the blood purification device, and set the total fluid replacement volume and the total blood purification time according to the input operation detected on the blood purification treatment interface.

[0048] Specifically, the two initial parameters of the blood purification device—total fluid replacement volume and total blood purification duration—need to be set in advance before starting the blood purification treatment phase. The total fluid replacement volume represents the total amount of replacement fluid the user expects to output throughout the entire blood purification treatment phase, and the total blood purification duration represents the total duration of the blood purification treatment the user expects. For example, as shown... Figure 4 On the blood purification treatment interface, the total fluid replacement volume is set to 1000g (this application uses the weight of the liquid to evaluate the liquid storage capacity of the replacement fluid bag), and the total blood purification time is set to 16h. The total fluid replacement volume and total blood purification time of the blood purification device can be directly set on the blood purification treatment interface based on user input, greatly simplifying the user's operation.

[0049] In some embodiments, step S105 involves displaying a blood purification treatment interface on the screen of the blood purification device, and setting the total fluid resuscitation volume and total blood purification duration based on the input operations detected on the blood purification treatment interface. Specifically, this includes:

[0050] Sub-step S1051: Display the selectable weight range and selectable time range on the blood purification treatment interface.

[0051] Sub-step S1052: Select a weight value from the weight selectable range based on the detected first selection input operation of the user, as the total fluid replacement volume; select a time value from the time selectable range based on the detected second selection input operation of the user, as the total blood purification time.

[0052] Specifically, the selectable weight range refers to the safe range of the total amount of replacement fluid output from the rehydration line, and the selectable time range refers to the safe range of the cumulative total time for the rehydration steps performed by the rehydration line. Both the selectable weight and time ranges can be pre-set based on clinical experience, and both are related to the blood purification treatment mode of the blood purification equipment. For example, when the blood purification treatment mode of the blood purification equipment is selected as plasma exchange therapy, the selectable weight range is 800g–1500g, and the selectable time range is 12h–24h. Only when a total rehydration volume is selected within the selectable weight range and a total blood purification duration is selected within the selectable time range can the blood purification treatment phase of the blood purification equipment be in a safe state. Therefore, combining… Figure 4When the user's first input is triggered in the input box corresponding to the total fluid replacement volume, a weight selection range will pop up on the blood purification treatment interface. The user simply needs to select a weight value from this range to complete the determination of the total fluid replacement volume. When the user's second input is triggered in the input box corresponding to the total blood purification duration, a time selection range will pop up on the blood purification treatment interface. The user simply needs to select a time value from this range to complete the determination of the total blood purification duration.

[0053] In this embodiment, the initial parameters of the blood purification device are limited to a specific safe range on the blood purification treatment interface. This not only speeds up the parameter evaluation efficiency but also avoids errors in the parameter evaluation process that could affect the operational safety of the blood purification device.

[0054] In some embodiments, step S101, before controlling the first peristaltic pump to start rotating at the first theoretical speed when the blood purification device enters the blood purification treatment stage, may further include:

[0055] Step S106: Calibrate the rotational speed of the first peristaltic pump so that there is a one-to-one correspondence between the calibrated rotational speed of the first peristaltic pump and the weight of the replacement fluid in the replacement fluid bag.

[0056] Specifically, as mentioned above, the first peristaltic pump uses a motor-driven principle. Therefore, the unit of the pump's rotational speed, detected by the Hall sensor, should be r / min. For example, if the pump's rotational speed is 10 r / min, and the theoretical rotational speed is measured in weight (g), a correlation needs to be established between the unit of rotational speed (r / min) and the unit of weight (g). The process of establishing this correlation between the pump's rotational speed and the weight of the replacement fluid in the replacement fluid bag is called calibration. There is a positive correlation between the pump's rotational speed and the replacement fluid flow rate in the replenishment branch, and also a positive correlation between the replenishment fluid flow rate and the actual weight reduction of the replacement fluid bag. For instance, the higher the pump's rotational speed, the greater the driving force it provides to the replenishment branch, resulting in a higher replacement fluid flow rate, a higher rate of replacement fluid output from the replacement fluid bag, a greater actual weight reduction in the replacement fluid bag, and a larger capacity of replacement fluid output to the blood circuit by the replenishment branch. Therefore, in this embodiment of the application, after calibrating the rotational speed of the first peristaltic pump, the rotational speed of the first peristaltic pump can be measured by the unit (g) of the weight of the replacement fluid bag, which greatly facilitates the calculation of the theoretical weight reduction of the replacement fluid bag.

[0057] For example, the specific method for "calibrating the rotational speed of the first peristaltic pump" can be as follows: Before starting the blood purification treatment phase, the rotational speed of the first peristaltic pump is tested multiple times, and the values ​​of the rotational speed of the first peristaltic pump and the weight reduction of the replacement fluid bag are recorded respectively to obtain a one-to-one correspondence between the rotational speed of the first peristaltic pump and the weight reduction of the replacement fluid bag, thus completing the calibration process; for example, after testing the rotational speed of the first peristaltic pump multiple times, it is found that whenever the rotational speed of the first peristaltic pump changes by 3 r / min, the weight reduction of the replacement fluid bag changes by 1 g / min, thus establishing the correlation between the rotational speed of the first peristaltic pump and the weight of the replacement fluid in the replacement fluid bag. After calibration, the conversion between the rotational speed of the first peristaltic pump and the weight reduction of the replacement fluid bag can be directly performed to ensure that the control method in this embodiment can be executed normally.

[0058] In some embodiments, the method may further include:

[0059] Step S107: When the blood purification device is in the blood purification treatment stage, the actual rotation speed of the first peristaltic pump is detected every preset cycle; when the actual rotation speed and the first theoretical rotation speed meet the first preset condition, a second fault alarm signal is issued, wherein the first preset condition is: the ratio of the absolute value of the second difference between the actual rotation speed and the first theoretical rotation speed to the first theoretical rotation speed is greater than or equal to a preset ratio.

[0060] The first preset condition is: |Actual speed of the first peristaltic pump - First theoretical speed of the first peristaltic pump| / First theoretical speed of the first peristaltic pump ≥ Preset ratio, for example, the preset ratio is 10%.

[0061] Specifically, during the blood purification treatment phase, the first peristaltic pump rotates to drive the replacement fluid in the fluid infusion branch to flow. The rotational speed of the first peristaltic pump is adjusted based on a first difference between the theoretical weight reduction and the actual weight reduction, thus changing the actual rotational speed of the first peristaltic pump. For example... Figure 5 The diagram shows the actual rotational speed variation curve of the first peristaltic pump. The deviation between the actual rotational speed and the theoretical rotational speed of the first peristaltic pump can be used to determine whether the actual rotation process of the first peristaltic pump is in a faulty state. When the first preset condition is met, if the rotational speed fluctuation of the first peristaltic pump exceeds the rotational speed error range, this indicates that the replenishment rate of the replenishment branch may have a sudden change, or that the first peristaltic pump itself has suffered physical damage. In this case, a second fault alarm signal needs to be issued immediately to remind the user that the rotational speed fluctuation of the first peristaltic pump is too large. The user needs to immediately address the rotational speed fault of the first peristaltic pump to ensure the safety of the rotational speed regulation of the first peristaltic pump.

[0062] It should be noted that after entering the blood purification treatment stage, the actual speed of the first peristaltic pump and its theoretical speed are continuously monitored to ensure they meet the first preset condition. Regardless of whether the fluid infusion step of the fluid infusion branch is in a normal state, a feedback adjustment state, or a fault state, the actual speed of the first peristaltic pump and its theoretical speed are monitored every preset period to ensure they meet the first preset condition. Although the speed of the first peristaltic pump is adjusted in the feedback adjustment state, if the actual speed of the first peristaltic pump after feedback adjustment meets the first preset condition, a second fault alarm signal will still be issued. Therefore, this embodiment of the application can ensure that the adjustment process of the actual speed of the first peristaltic pump during the blood purification treatment stage does not exceed the user-allowed speed error range, improving the safety and control flexibility of the fluid infusion step of the fluid infusion branch.

[0063] It is important to distinguish between the "rotational speed difference" in S106 and the "weight difference" in S104, as these are two completely different concepts. The "rotational speed difference" in S106 refers to the difference between the actual rotational speed of the first peristaltic pump and its theoretical rotational speed. The "weight difference" in S104 refers to the difference between the theoretical weight reduction and the actual weight reduction. Furthermore, the actual weight reduction in S104 is the actual weight reduction of the replacement fluid bag detected by the first weighing scale, and it is not directly related to the rotational speed of the first peristaltic pump. Therefore, this embodiment monitors the replenishment step of the replenishment branch for faults in both S104 and S106 through two dimensions.

[0064] In some embodiments, step S103, where the absolute value of the first difference between the theoretical weight reduction and the actual weight reduction is greater than a first preset weight and less than or equal to a second preset weight, involves feedback adjustment of the rotational speed of the first peristaltic pump based on the first difference, may include:

[0065] Sub-step S1031: When the difference between the theoretical weight reduction and the actual weight reduction is greater than the first preset weight and less than or equal to the second preset weight, the rotation speed of the first peristaltic pump is increased.

[0066] Sub-step S1032: When the difference between the actual weight reduction and the theoretical weight reduction is greater than the first preset weight and less than or equal to the second preset weight, the rotation speed of the first peristaltic pump is reduced.

[0067] If the first preset weight < theoretical weight reduction - actual weight reduction ≤ second preset weight, then the speed of the first peristaltic pump will be increased; if the first preset weight < actual weight reduction - theoretical weight reduction ≤ second preset weight, then the speed of the first peristaltic pump will be decreased.

[0068] Specifically, if the first preset weight <|theoretical weight reduction - actual weight reduction| ≤ the second preset weight, it can be further divided into the following two cases: 1. When the actual weight reduction of the replacement fluid bag is low, that is: first preset weight < theoretical weight reduction - actual weight reduction ≤ second preset weight, then the speed of the first peristaltic pump is increased, the driving force provided by the first peristaltic pump to the replenishment branch will also increase, the actual output rate of the replacement fluid in the replenishment branch will also increase, the weight of the replacement fluid output by the replacement fluid bag will also increase, and the actual weight reduction will gradually increase after feedback adjustment; 2. When the actual weight reduction of the replacement fluid bag is high, that is: first preset weight < actual weight reduction - theoretical weight reduction ≤ second preset weight, then the speed of the first peristaltic pump is decreased, the driving force provided by the first peristaltic pump to the replenishment branch will also decrease, the actual output rate of the replacement fluid in the replenishment branch will also decrease, the weight of the replacement fluid output by the replacement fluid bag will also decrease, and the actual weight reduction will gradually decrease after feedback adjustment. Therefore, in this embodiment, the rotation speed of the first peristaltic pump is adjusted according to the relative magnitude of the actual weight reduction and the theoretical weight reduction in each preset cycle, thereby improving the accuracy of the feedback adjustment of the rotation speed of the first peristaltic pump.

[0069] For example, in the embodiments of this application, the specific methods for "increasing the speed of the first peristaltic pump" and "decreasing the speed of the first peristaltic pump" can employ speed feedback adjustment methods in related technologies, such as PID (Proportion-Integration-Derivative) control methods. PID control is a linear control method, which is essentially a composite control of the proportional, integral, and derivative of the system deviation. The controller performs comprehensive control of the proportional, integral, and derivative of the system deviation based on the deviation between the given value and the feedback value. In the embodiments of this application, by using feedback control of the speed of the first peristaltic pump, the actual weight reduction of the replacement fluid bag after feedback adjustment can quickly return to the user-acceptable error range.

[0070] In some embodiments, please combine Figure 1 and Figure 2The blood purification device further includes: a second weighing scale, a second peristaltic pump, a waste fluid bag, and a waste fluid branch. One end of the waste fluid branch is connected to the blood circuit, and the other end is connected to the waste fluid bag. The waste fluid branch is mounted on the second peristaltic pump. The waste fluid bag is used to collect the waste fluid output from the waste fluid branch, and the second weighing scale is used to detect the weight of the waste fluid bag. As described above, during the blood purification treatment stage, waste fluid is removed from the patient's blood by the blood purifier. The waste fluid is output to the waste fluid bag through the waste fluid branch, and the waste fluid bag can collect the waste fluid output from the waste fluid branch for analysis to determine the patient's blood purification treatment status. The second peristaltic pump provides driving force to the waste fluid branch. The rotation speed of the second peristaltic pump controls the waste fluid output rate of the waste fluid branch, allowing the waste fluid branch to output waste fluid to the waste fluid bag at a specific rate. The weight of the waste fluid bag is detected by the second weighing scale, and the weight of the waste fluid bag can be used to more accurately determine whether there is a malfunction in the patient's waste fluid removal process.

[0071] At this point, the method may further include:

[0072] Step S108: When the blood purification device enters the blood purification treatment stage, the second peristaltic pump is controlled to start rotating at the second theoretical speed. The second theoretical speed is calculated based on the total dehydration volume and the total blood purification time. The second theoretical speed is equal to the total dehydration volume divided by the total blood purification time. The total dehydration volume is preset based on the total fluid replacement volume.

[0073] The total fluid replacement volume represents the total amount of replacement fluid output to the blood circuit, while the total dehydration volume represents the total amount of waste fluid removed from the blood circuit. These two volumes exhibit a specific correlation; for example, total dehydration volume = first ratio * total fluid replacement volume. The first ratio is related to the blood purification treatment mode of the blood purification device, and it is a value preset by the user based on clinical experience. For instance, in plasma exchange therapy mode, the first ratio can be any value within the range of 0.99 to 1.01. Therefore, when the user sets the total fluid replacement volume and total blood purification duration on the blood purification treatment interface, the total dehydration volume will be set according to the total fluid replacement volume to maintain the patient's fluid balance during blood purification treatment.

[0074] The second theoretical rotational speed of the blood purification device is calculated based on the total dehydration volume and the total blood purification time; wherein, the second theoretical rotational speed = total dehydration volume / total blood purification time.

[0075] When the blood purification device enters the blood purification treatment stage, the second peristaltic pump is controlled to start rotating at the second theoretical speed.

[0076] Step S109: Every preset period, determine the theoretical weight increase of the waste liquid bag according to the second theoretical rotation speed, and use the second weighing scale to detect the actual weight increase of the waste liquid bag.

[0077] Step S110: When the absolute value of the third difference between the theoretical weight increase and the actual weight increase is greater than the third preset weight and less than or equal to the fourth preset weight, the rotation speed of the second peristaltic pump is adjusted according to the third difference; when the absolute value of the third difference is greater than the fourth preset weight, a third fault alarm signal is issued.

[0078] Preferably, the third preset weight is equal to the first preset weight, and the fourth preset weight is equal to the second preset weight.

[0079] If the third preset weight <|theoretical weight increase - actual weight increase| ≤ the fourth preset weight, then the rotational speed of the second peristaltic pump is adjusted based on the third difference between the theoretical weight increase and the actual weight increase.

[0080] If the fourth preset weight is less than |theoretical weight increase - actual weight increase|, then a third fault alarm signal will be issued.

[0081] It should be noted that the specific implementations of S108 to S110 are similar to those of S101 to S104. Therefore, the specific implementations of S108 to S110 can be referred to the specific implementations of S101 to S104, and will not be repeated here.

[0082] This application embodiment monitors the actual status of the waste liquid removal step in the waste liquid branch in real time. Based on the difference between the theoretical weight increase and the actual weight increase, the rotation speed of the second peristaltic pump is adjusted accordingly. After the feedback adjustment, the total amount of waste liquid output from the waste liquid branch is always in a normal state. The waste liquid can be safely output to the waste liquid bag through the waste liquid branch, and the balance between the fluid replenishment step and the waste liquid removal step is maintained during the blood purification treatment stage.

[0083] In some embodiments, the method may further include:

[0084] Step S111: When the blood purification device is in the blood purification treatment stage, the actual speed of the first peristaltic pump and the actual speed of the second peristaltic pump are detected every preset period. When the absolute value of the fourth difference between the actual speed of the first peristaltic pump and the actual speed of the second peristaltic pump is greater than the first preset speed, and the duration of the fourth difference being greater than the first preset speed exceeds the first safe time, a fourth fault alarm signal is issued.

[0085] Specifically, during the blood purification treatment phase, the first peristaltic pump and the second peristaltic pump operate simultaneously, and feedback adjustments are made to the rotation speed of the first peristaltic pump and the rotation speed of the second peristaltic pump, respectively. In S111, by comparing the actual rotation speed of the first peristaltic pump and the actual rotation speed of the second peristaltic pump, the deviation between the fluid replenishment step and the waste fluid removal step in the actual state of the blood purification equipment can be determined. When the absolute value of the fourth difference between the actual speed of the first peristaltic pump and the actual speed of the second peristaltic pump is greater than the first preset speed, it indicates that the deviation between the fluid replenishment step and the waste fluid removal step is too large, and the patient's body fluid is unbalanced. Furthermore, when the absolute value of the fourth difference between the actual speed of the first peristaltic pump and the actual speed of the second peristaltic pump is greater than the first preset speed for a duration exceeding the first safety time, this excludes accidental errors in the blood purification equipment (such as shaking of the replacement fluid bag, shaking of the waste fluid bag, etc.) that cause an imbalance in the speed measurement value. When a patient's body fluid imbalance is detected, a fourth fault alarm signal (e.g., an audible and visual prompt signal) is issued to notify the user that a large deviation has occurred between the fluid replenishment step and the waste fluid removal step during the blood purification treatment. When the user notices the fourth fault alarm signal (e.g., the audible and visual prompt signal), they will immediately address the body fluid imbalance fault, greatly ensuring the patient's body fluid balance and the safety of blood purification treatment.

[0086] In some embodiments, the method may further include:

[0087] Step S112: When the absolute value of the first difference is less than or equal to the first preset weight, the actual weight reduction of the replacement fluid bag is recorded n times consecutively. The actual weight reduction rate of the replacement fluid bag for n-1 consecutive times is determined based on the actual weight reduction of the replacement fluid bag for n-1 consecutive times. If the difference between the maximum and minimum values ​​of the actual weight reduction rates for n-1 consecutive times is greater than or equal to the fifth preset weight, a fifth fault alarm signal is issued, where n is a positive integer greater than 1.

[0088] Preferably, the fifth preset weight is equal to the first preset weight.

[0089] Specifically, if |theoretical weight reduction - actual weight reduction| ≤ the first preset weight, this indicates that the fluid replacement branch is in a normal state during the fluid replacement step. In this normal state, there is no feedback adjustment to the speed of the first peristaltic pump. Therefore, the speed of the first peristaltic pump should remain constant, the flow rate of the replacement fluid in the fluid replacement branch should remain constant, the actual output rate of the replacement fluid in the replacement fluid bag should remain constant, and the actual weight reduction rate of the replacement fluid bag should also remain constant. Please pay close attention to the distinction between the actual weight reduction rate and the actual weight reduction amount. Actual weight reduction amount = initial weight of the replacement fluid bag - weight of the replacement fluid bag detected in the preset cycle; Actual weight reduction rate = weight of the replacement fluid bag detected in the current preset cycle - weight of the replacement fluid bag detected in the next preset cycle. The actual weight reduction rate represents the volume of replacement fluid output by the replacement fluid bag within a preset cycle, while the actual weight reduction amount represents the cumulative weight of replacement fluid actually output by the replacement fluid bag during the blood purification treatment phase up to the current preset cycle.

[0090] In this embodiment of the application, when the absolute value of the first difference is less than or equal to the fifth preset weight, the actual weight reduction of the replacement fluid bag is recorded n times (e.g., 4 times). Based on the actual weight reduction of the replacement fluid bag n times (e.g., 4 times), the actual weight reduction rate for n-1 times (e.g., 3 times) is calculated. The actual weight reduction rates detected for n-1 times (e.g., 3 times) are sorted. The difference between the maximum and minimum values ​​represents the fluctuation of the actual output rate of the replacement fluid. When the difference between the maximum and minimum values ​​is greater than or equal to the fifth preset weight, it indicates that the first weighing scale has malfunctioned in the weight detection process of the replacement fluid bag. The cause of the malfunction is usually that the first weighing scale is shaking. At this time, a fifth fault alarm signal (e.g., audible and visual fault prompt information) is issued to prompt the user that the first weighing scale has malfunctioned. When the user notices the fifth fault alarm signal (e.g., audible and visual fault prompt information), he will immediately eliminate the fault factor of the first weighing scale. This avoids the weighing detection error of the replacement fluid bag caused by the malfunction of the first weighing scale itself, and improves the accuracy and stability of the control method of this embodiment of the application.

[0091] It should be noted that in S112, the actual weight reduction of the replacement fluid bag is detected and recorded by the first weighing scale for n consecutive (e.g., 4) preset cycles. For example, if the preset cycle is 3 seconds, the actual weight reduction values ​​recorded 4 times within 9 seconds are 100g, 100.4g, 101.1g, and 101.6g respectively. Then, the actual weight reduction rates for 3 consecutive times are 0.4g (100.4g - 100g = 0.4g), 0.7g (101.1g - 100.4g = 0.7g), and 0.5g respectively. (101.6g-101.1g=0.5g), the actual weight reduction rate of the three consecutive times is sorted as follows: 0.7g (maximum value), 0.5g, 0.4g (minimum value), and the difference between the maximum and minimum values ​​is 0.7g-0.4g=0.3g; if the user sets the fifth preset weight to 0.2g based on clinical technical experience, and 0.3g>0.2g, then the shaking fault of the first weighing scale is determined, and the fifth fault alarm signal (e.g., audible and visual fault prompt information) is issued to prompt the user that the first weighing scale itself has shaken.

[0092] It should be noted that S112 will only be executed when |theoretical weight reduction - actual weight reduction| ≤ the first preset weight. This is because if the first preset weight < |theoretical weight reduction - actual weight reduction|, the replenishment step is in a feedback adjustment state or a fault state, and the calculated actual weight reduction rate of the replacement fluid bag has no practical reference value. Therefore, this embodiment will only calculate the actual weight reduction rate of the replacement fluid bag when the replenishment step is in a normal state. Furthermore, when the difference between the maximum and minimum values ​​is greater than or equal to the fifth preset weight, this only indicates a fault in the first weighing scale's weight detection process for the replacement fluid bag; the absolute value of the difference between the theoretical weight reduction and the actual weight reduction of the replacement fluid bag is still less than or equal to the first preset weight.

[0093] In some embodiments, please combine Figure 1 and Figure 2 The blood purification device further includes a third peristaltic pump, and the blood circuit is disposed on the third peristaltic pump; the rotation of the third peristaltic pump provides driving force to the blood circuit to drive the blood flow and blood direction in the blood circuit; wherein the greater the rotation speed of the third peristaltic pump, the greater the blood flow in the blood circuit.

[0094] At this point, the method may further include:

[0095] Step S113: When the blood purification device enters the blood purification treatment stage, the third peristaltic pump is controlled to start rotating at the third theoretical speed, which is calculated based on the first theoretical speed.

[0096] Step S114: When adjusting the rotational speed of the first peristaltic pump, adjust the rotational speed of the third peristaltic pump according to the adjusted rotational speed of the first peristaltic pump.

[0097] The third theoretical speed of the third peristaltic pump is calculated based on the first theoretical speed. Optionally, the formula for calculating the third theoretical speed of the third peristaltic pump is: Third theoretical speed = First theoretical speed / (3%~5%); for example, in the formula for calculating the third theoretical speed, if 4% is taken, the first theoretical speed is 1.04 g / min, and the third theoretical speed is = 1.04 g / min / 0.04 = 26 g / min. Then, the third peristaltic pump is controlled to rotate at 26 g / min to drive the blood flow in the blood circuit. After calculating the first theoretical speed of the first peristaltic pump, the third theoretical speed of the third peristaltic pump can be calculated according to a specific formula, and the first and third peristaltic pumps can achieve linkage control.

[0098] During the blood purification treatment phase, both the first and third peristaltic pumps operate. When performing the fluid replacement step in the fluid replacement branch, the rotation speed of the first peristaltic pump is adjusted based on feedback, either increasing or decreasing. To maintain a matching change between the blood flow in the blood circuit and the replacement fluid flow in the fluid replacement branch, this embodiment also adjusts the rotation speed of the third peristaltic pump based on the adjusted rotation speed of the first peristaltic pump, so that the rotation speed of the third peristaltic pump changes in accordance with the change in the rotation speed of the first peristaltic pump. It should be noted that in S114, the rotation speed of the first peristaltic pump refers to its actual rotation speed, not its theoretical rotation speed; similarly, in S114, the rotation speed of the third peristaltic pump refers to its actual rotation speed, not its theoretical rotation speed. Therefore, even though the first peristaltic pump is in a feedback regulation state, the speed of the third peristaltic pump after feedback regulation and the speed of the first peristaltic pump after feedback regulation can always change synchronously. The replacement fluid output through the fluid replenishment branch can just meet the patient's fluid replenishment needs during the blood purification treatment stage, ensuring the control safety of the blood purification equipment.

[0099] In step S114, the speed of the third peristaltic pump is adjusted based on the speed of the first peristaltic pump after feedback adjustment. The specific calculation formula for the feedback adjustment of the speed is: the speed of the third peristaltic pump after feedback adjustment = the speed of the first peristaltic pump after feedback adjustment / (2% to 6%). Therefore, once the speed of the first peristaltic pump is adjusted, the speed of the third peristaltic pump after feedback adjustment can be calculated according to the above calculation formula, so that the speeds of the first and third peristaltic pumps can be adjusted synchronously.

[0100] In some embodiments, the method further includes:

[0101] Step S115: When the absolute value of the first difference is less than or equal to the first preset weight, the actual rotation speed of the first peristaltic pump is detected every preset period, and it is determined whether the actual rotation speed of the first peristaltic pump exceeds the safe rotation speed range. When it is determined that the actual rotation speed of the first peristaltic pump exceeds the safe rotation speed range, a sixth fault alarm signal is issued.

[0102] If |theoretical weight reduction - actual weight reduction| ≤ the first preset weight, then the fluid replenishment step is in normal condition.

[0103] Specifically, under normal conditions during the replenishment process, the speed of the first peristaltic pump is not adjusted, and theoretically, its speed should remain constant. However, due to the long-term compression and drive of the replenishment branch by the first peristaltic pump, its drive control performance changes. For example, even with the input voltage and current of the first peristaltic pump remaining constant, the resistance to its rotation changes due to deformation caused by the long-term compression, leading to a change in the actual speed of the first peristaltic pump and consequently, a change in the flow rate of the replacement fluid in the replenishment branch driven by the first peristaltic pump. This situation constitutes a fault. Therefore, when the actual speed of the first peristaltic pump exceeds the safe speed range under normal replenishment conditions, a sixth fault alarm signal is issued to indicate that the first peristaltic pump is malfunctioning. Upon noticing the sixth fault alarm signal, the user will immediately address the malfunction. This method ensures a more comprehensive guarantee of the operational safety of the first peristaltic pump.

[0104] Specifically, the safe operating speed range represents the safe fluctuation range of the first peristaltic pump's operating speed. Only when the actual operating speed of the first peristaltic pump is within the safe operating speed range will the flow rate of the replacement fluid in the replenishment branch controlled by the first peristaltic pump be in a safe flow state. The safe operating speed range can be preset based on clinical experience, for example, 0.2 g / min to 3 g / min. Then, if the actual operating speed of the first peristaltic pump is detected to be less than 0.2 g / min when |theoretical weight reduction - actual weight reduction| ≤ the first preset weight, it is determined that the actual operating speed of the first peristaltic pump exceeds the safe operating speed range, and a third fault alarm signal is issued.

[0105] It should be noted that in the above S115, although it is determined that the actual speed of the first peristaltic pump exceeds the safe speed range, the condition "|theoretical weight reduction - actual weight reduction| ≤ first preset weight" is still satisfied. This is because the actual speed of the first peristaltic pump exceeds the safe speed range, and the actual weight reduction of the replacement fluid bag controlled by the first peristaltic pump will fluctuate. However, the actual weight reduction after such fluctuation is within the error range allowed by the user. In other words, step S115 is a step that is only executed when the fluid replenishment step is in a normal state.

[0106] In some embodiments, the method further includes:

[0107] Step S116: Before the blood purification equipment enters the blood purification treatment stage, perform fault self-checks on the first weighing scale and the first peristaltic pump respectively.

[0108] Specifically, before entering the blood purification treatment stage, a fault self-check needs to be performed on the first weighing scale and the first peristaltic pump to rule out the possibility that faults in the first weighing scale and the first peristaltic pump themselves could cause errors in the judgment of the fluid infusion step during the blood purification treatment stage. After S116, the interference of physical faults in the first weighing scale and the first peristaltic pump on the judgment process of the fluid infusion step can be eliminated. For example, the physical fault of the first weighing scale is that the outer shell of the first weighing scale is damaged, resulting in errors in the weighing result; another example is that the physical fault of the first peristaltic pump is that the circuit of the first peristaltic pump causes the drive of the first peristaltic pump to fail. Therefore, the embodiments of this application can improve the applicability and accuracy of the control method.

[0109] In some embodiments, step S116, which involves performing fault self-checks on the first weighing scale and the first peristaltic pump respectively, may include:

[0110] Sub-step S1161: Control the first peristaltic pump to start rotating.

[0111] Sub-step S1162: Detect the actual rotational speed of the first peristaltic pump, and use the first weighing scale to detect the rate of decrease in liquid weight of the replacement fluid bag.

[0112] Sub-step S1163: Continuously adjust the rotation speed of the first peristaltic pump and plot the relationship curve between the actual rotation speed of the first peristaltic pump and the rate of decrease in liquid weight of the replacement fluid bag.

[0113] Sub-step S1164: Determine whether the first weighing scale and the first peristaltic pump are malfunctioning based on the relationship curve.

[0114] Before entering the blood purification treatment stage, the replacement fluid bag also stores replacement fluid. The first peristaltic pump starts to rotate, and the rotation of the first peristaltic pump provides driving force to the fluid infusion branch, which outputs the fluid from the replacement fluid bag, and the weight of the fluid stored in the replacement fluid bag will also decrease. When the speed of the first peristaltic pump is continuously adjusted, for example, increasing the speed of the first peristaltic pump from small to large, the rate of decrease of the weight of the fluid in the replacement fluid bag will also increase from small to large. By recording the actual speed of the first peristaltic pump and the corresponding rate of decrease of the weight of the replacement fluid bag, a curve showing the relationship between the actual speed of the first peristaltic pump and the rate of decrease of the weight of the replacement fluid bag is plotted.

[0115] For example, such as Figure 6 As shown, the solid line curve represents the relationship between the actual rotational speed of the first peristaltic pump and the rate of decrease in the liquid weight of the replacement fluid bag under normal conditions. This situation represents a successful self-test of both the first weighing scale and the first peristaltic pump. In this case, the actual rotational speed of the first peristaltic pump and the rate of decrease in the liquid weight of the replacement fluid bag exhibit a strictly linear increasing function relationship. Only after the first weighing scale and the first peristaltic pump have successfully completed the self-test will the blood purification equipment enter the blood purification treatment stage. The dashed line curve represents the relationship between the actual rotational speed of the first peristaltic pump and the rate of decrease in the liquid weight of the replacement fluid bag under abnormal conditions. This situation indicates that the first weighing scale and / or the first peristaltic pump has malfunctioned, and the self-test has failed. Therefore, this embodiment of the application can complete the self-test process for both the first weighing scale and the first peristaltic pump based on the relationship curve between the actual rotational speed of the first peristaltic pump and the rate of decrease in the liquid weight of the replacement fluid bag, ensuring the accuracy and applicability of the control method.

[0116] It should be noted that the liquid weight reduction rate of the replacement fluid bag refers to the amount of liquid weight reduction in the replacement fluid bag per unit time. Please distinguish between the liquid weight reduction rate of the replacement fluid bag and the actual weight reduction of the replacement fluid bag.

[0117] During the blood purification treatment phase, blood flows within the blood circuit. The fluid replacement branch outputs replacement fluid to the blood circuit, and the blood purification equipment performs normal blood purification treatment on the patient's blood. The first peristaltic pump and the first weighing scale are powered on and operate. However, the total duration of blood purification is typically 12 to 24 hours. Therefore, during the blood purification treatment phase, the blood purification equipment may receive an abnormal stop command and cease operation. When the blood purification equipment stops, all components on the equipment (such as the first peristaltic pump and the first weighing scale) will lose power and stop. It should be noted that the abnormal stop command can be issued by the user or when the blood purification equipment malfunctions. For example, when a patient needs to eat, rest, or use the restroom after a period of time during blood purification treatment, the user can issue an abnormal stop command to control the blood purification equipment to lose power and stop. Similarly, if the blood purification equipment detects physical faults during operation (such as tubing detachment or abnormal power loss), it will also issue an abnormal stop command to cause all components on the blood purification equipment to lose power and stop.

[0118] When the blood purification equipment receives an abnormal stop command, the first peristaltic pump and the first weighing scale will lose power and stop. However, please combine this with... Figure 1 and Figure 2 The replacement fluid bags are suspended on top of the blood purification equipment, and the rehydration branch is always in a conductive state. Therefore, when the blood purification equipment is in a stopped state, the replacement fluid in the replacement fluid bag will also be output to the rehydration branch due to gravity. In this case, the first weighing scale has lost power and stopped, so it is impossible to determine whether the body fluid is unbalanced by the weighing result of the first weighing scale.

[0119] In some embodiments, the method may further include:

[0120] Step S117: When the blood purification device is in the blood purification treatment stage, if an abnormal stop command is received, the first peristaltic pump and the first weighing scale are controlled to stop due to power failure, and the theoretical weight reduction of the replacement fluid bag and the actual weight reduction of the replacement fluid bag are recorded.

[0121] Step S118: Determine the first weight reduction of the replacement fluid bag over a first preset time period, the first preset time period being set based on the first theoretical rotational speed.

[0122] Step S119: If the theoretical weight reduction and the actual weight reduction satisfy the second preset condition, then issue a seventh fault alarm signal; the second preset condition is: the absolute value of the difference between the theoretical weight reduction and the first weight reduction and the actual weight reduction is greater than the second preset weight.

[0123] The second preset condition is: second preset weight < |theoretical weight reduction - first weight reduction - actual weight reduction|.

[0124] Specifically, the first preset duration can represent the duration for which the replacement fluid bag outputs replacement fluid due to gravity after the blood purification equipment stops. The first preset duration is determined by the first theoretical speed of the first peristaltic pump. For example, the higher the first theoretical speed, the greater the actual output rate of the replacement fluid in the replenishment branch. When the first weighing scale suddenly loses power and stops, the residual replacement fluid in the replenishment branch will have a greater inertial effect, and the duration for which the replenishment branch outputs the residual replacement fluid will also be longer.

[0125] For example, a curve showing the correspondence between the first theoretical rotational speed and the first preset duration can be derived through clinical technical experience. Figure 7 The curve showing the correspondence between the first theoretical rotational speed and the first preset duration is illustrated. Figure 7 The relationship curves in the text are derived from clinical technical experience, therefore, the relationships described here are... Figure 7 The specific source of the relationship curves in the calculation is not described in detail. When calculating the first theoretical speed of the first peristaltic pump, according to... Figure 7 The corresponding first preset duration can be found by looking at the relationship curve in the graph.

[0126] When the blood purification device enters the blood purification treatment stage, it will lose power and stop upon receiving an abnormal stop command. At the moment of power loss, the theoretical and actual weight reduction of the replacement fluid bag will be recorded. It is important to note that these two values ​​represent the values ​​at the instant of power loss; because once the blood purification device loses power, both the first peristaltic pump and the first weighing scale have stopped, making it impossible to continue detecting the actual weight reduction or calculating the theoretical weight reduction of the replacement fluid bag. Upon receiving an abnormal stop command, this embodiment records the theoretical and actual weight reduction of the replacement fluid bag at the instant of power loss.

[0127] The first weight reduction represents the theoretical total amount of replacement fluid output by the replacement fluid bag within the first preset time period. It should be noted that the first weight reduction is the cumulative total amount of replacement fluid output by the replacement fluid bag within the first preset time period after the moment the blood purification equipment stops powering off. This needs to be distinguished from the actual weight reduction of the replacement fluid bag, because the actual weight reduction of the replacement fluid bag is the cumulative weight of the replacement fluid output after the start of the blood purification treatment phase.

[0128] As mentioned above, since the blood purification equipment stops working after a power outage, the weight reduction of the replacement fluid bag cannot be detected within the first preset time period. Therefore, the first weight reduction is a theoretical value used to compensate for the inability of the first weighing scale to continue weighing the replacement fluid bag. For example, the specific formula for calculating the first weight reduction can be: First weight reduction = First preset time period * Average weight reduction, where the average weight reduction represents the average actual weight reduction of the replacement fluid bag during the blood purification treatment phase. For instance, if the cumulative blood purification treatment phase lasts for 4 hours and the actual weight reduction of the replacement fluid bag is 300g, then the average weight reduction = actual weight reduction of the replacement fluid bag / cumulative blood purification time = 300 / 240g / min = 1.25g / min; if the first preset time period = 0.2min, the first weight reduction = 1.25 * 0.2g = 0.25g.

[0129] "First weight reduction + actual weight reduction" represents the cumulative weight of the replacement fluid output from the replacement fluid bag after the blood purification equipment stops operating due to power failure. Note that this "cumulative weight" includes both the cumulative weight of the replacement fluid bag detected by the first weighing scale and the cumulative weight of the replacement fluid output by the replacement fluid bag due to gravity after the power failure. When the second preset condition is met, the cumulative weight of the replacement fluid output by the replacement fluid bag exceeds the safe error range. A seventh fault alarm signal is issued to the user, indicating that the replacement fluid bag continues to output replacement fluid under gravity after the power failure, causing a malfunction in the fluid resuscitation step. Upon noticing the seventh fault alarm signal, the user will immediately address the malfunction in the fluid resuscitation step. This embodiment of the application can continue to monitor and assess the malfunction status of the fluid resuscitation step after the blood purification equipment stops operating due to power failure, thus more comprehensively ensuring the safety of the patient's blood purification treatment.

[0130] It should be noted that the "theoretical weight reduction" of the replacement fluid bag is the theoretical weight reduction calculated based on the first theoretical rotational speed of the first peristaltic pump at the instant of power failure. The "theoretical weight reduction" represents the standard weight reduction of the replacement fluid during the second preset condition judgment process, and the theoretical weight reduction remains unchanged within the first preset time period. "|theoretical weight reduction - first weight reduction - actual weight reduction|" represents the cumulative weight error caused by the replacement fluid output by the replacement fluid bag under the action of gravity. This allows for accurate determination of whether there is a fault in the replenishment step of the replenishment branch after power failure, resulting in higher fault judgment accuracy.

[0131] After the blood purification equipment stops briefly due to power failure, it will be powered on again and restarted. The first peristaltic pump and the first weighing scale will also be powered on and restarted. After restarting, the theoretical weight reduction of the replacement fluid bag will be recalculated based on the first theoretical rotational speed of the first peristaltic pump, and the actual weight reduction of the replacement fluid bag will be detected again using the first weighing scale. Then, the control method of the blood purification equipment will continue to be executed according to S103 and S104.

[0132] It should be noted that the sequence numbers of the above steps (such as S101, S102, etc.) are only used to refer to each step and do not mean that the steps in this application embodiment will be executed in the order of the sequence numbers. The steps in this application embodiment will be executed in the logical order of the technical solution.

[0133] This application also provides a computer-readable storage medium storing a computer program that, when executed by a processor, causes the processor to implement the control method for the blood purification device as described above. For detailed descriptions of the related content, please refer to the relevant content of the above methods, which will not be repeated here.

[0134] The computer-readable storage medium can be an internal storage unit of the aforementioned blood purification device, such as a hard drive or memory. Alternatively, it can be an external storage device, such as an external hard drive, smart memory card, secure digital card, flash memory card, etc.

[0135] It should be understood that the terminology used in this application specification is for the purpose of describing particular embodiments only and is not intended to limit the application.

[0136] It should also be understood that the term “and / or” as used in this application specification and the appended claims means any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0137] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and such modifications or substitutions should all be covered within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A blood purification device, characterized in that, The blood purification device includes: a first weighing scale, a first peristaltic pump, a replacement fluid bag, a rehydration branch, and a blood circuit; the blood circuit is used to transport blood, the replacement fluid bag is used to store replacement fluid, the first weighing scale is used to detect the weight of the replacement fluid bag, one end of the rehydration branch is connected to the blood circuit, and the other end of the rehydration branch is connected to the replacement fluid bag, the rehydration branch is disposed on the first peristaltic pump; the blood purification device further includes: a memory and a processor, the memory is used to store a computer program, and the processor is used to execute the computer program and, when executing the computer program, implement the following control method for the blood purification device: When the blood purification device enters the blood purification treatment stage, the first peristaltic pump is controlled to start rotating at a first theoretical speed. The first theoretical speed is calculated based on the preset total fluid resuscitation volume and the preset total blood purification time. The first theoretical speed is equal to the total fluid resuscitation volume divided by the total blood purification time. The rotational speed of the first peristaltic pump is calibrated so that there is a one-to-one correspondence between the calibrated rotational speed of the first peristaltic pump and the weight of the replacement fluid in the replacement fluid bag; Every preset period, the theoretical weight reduction of the replacement fluid bag is determined based on the first theoretical rotation speed and the cumulative blood purification time. The theoretical weight reduction is equal to the first theoretical rotation speed multiplied by the cumulative blood purification time. The actual weight reduction of the replacement fluid bag is detected using the first weighing scale. The actual weight reduction is equal to the initial weight of the replacement fluid bag minus the actual weight of the replacement fluid bag. When the absolute value of the first difference between the theoretical weight reduction and the actual weight reduction is greater than the first preset weight and less than or equal to the second preset weight, the rotation speed of the first peristaltic pump is adaptively adjusted according to the first difference using a PID control method, so that the actual weight reduction of the replacement fluid bag approaches the theoretical weight reduction.

2. The blood purification device according to claim 1, characterized in that, The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: When the blood purification device is in the blood purification treatment stage, the actual rotation speed of the first peristaltic pump is detected every preset cycle. When the actual rotational speed and the first theoretical rotational speed meet the first preset condition, a second fault alarm signal is issued. The first preset condition is that the ratio of the absolute value of the second difference between the actual rotational speed and the first theoretical rotational speed to the first theoretical rotational speed is greater than or equal to a preset ratio.

3. The blood purification device according to claim 1, characterized in that, The blood purification device further includes: a second weighing scale, a second peristaltic pump, a waste liquid bag, and a waste liquid branch; one end of the waste liquid branch is connected to the blood circuit, the other end of the waste liquid branch is connected to the waste liquid bag, the waste liquid branch is installed on the second peristaltic pump, the waste liquid bag is used to collect the waste liquid output by the waste liquid branch, and the second weighing scale is used to detect the weight of the waste liquid bag; The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: When the blood purification device enters the blood purification treatment stage, the second peristaltic pump is controlled to start rotating at the second theoretical speed. The second theoretical speed is calculated based on the total dehydration volume and the total blood purification time. The second theoretical speed is equal to the total dehydration volume divided by the total blood purification time. The total dehydration volume is preset based on the total fluid replacement volume. Every preset period, the theoretical weight increase of the waste liquid bag is determined based on the second theoretical rotation speed, and the actual weight increase of the waste liquid bag is detected using the second weighing scale. When the absolute value of the third difference between the theoretical weight increase and the actual weight increase is greater than the third preset weight and less than or equal to the fourth preset weight, the rotational speed of the second peristaltic pump is adjusted according to the third difference. When the absolute value of the third difference is greater than the fourth preset weight, a third fault alarm signal is issued.

4. The blood purification device according to claim 3, characterized in that, The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: When the blood purification device is in the blood purification treatment stage, the actual rotation speed of the first peristaltic pump and the actual rotation speed of the second peristaltic pump are detected every preset period. When the absolute value of the fourth difference between the actual speed of the first peristaltic pump and the actual speed of the second peristaltic pump is greater than the first preset speed, and the duration for which the absolute value of the fourth difference is greater than the first preset speed exceeds the first safe time, a fourth fault alarm signal is issued.

5. The blood purification device according to claim 1, characterized in that, The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: When the absolute value of the first difference is less than or equal to the first preset weight, the actual weight reduction of the replacement fluid bag is recorded n times consecutively. The actual weight reduction rate of the replacement fluid bag for n-1 consecutive times is determined based on the actual weight reduction of the replacement fluid bag for n-1 consecutive times. If the difference between the maximum and minimum values ​​of the actual weight reduction rates for n-1 consecutive times is greater than or equal to the fifth preset weight, a fifth fault alarm signal is issued, where n is a positive integer greater than 1.

6. The blood purification device according to claim 1, characterized in that, The blood purification device further includes: a third peristaltic pump, and the blood circuit is disposed on the third peristaltic pump; The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: When the blood purification device enters the blood purification treatment stage, the third peristaltic pump is controlled to start rotating at a third theoretical speed, which is calculated based on the first theoretical speed. When the rotational speed of the first peristaltic pump is adjusted by feedback, the rotational speed of the third peristaltic pump is adjusted by feedback based on the rotational speed of the first peristaltic pump after feedback adjustment.

7. The blood purification device according to claim 1, characterized in that, The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: Before the blood purification equipment enters the blood purification treatment stage, the first weighing scale and the first peristaltic pump are respectively subjected to fault self-checks. The self-checking of the first weighing scale and the first peristaltic pump specifically includes: Control the first peristaltic pump to start rotating; The actual rotational speed of the first peristaltic pump is detected, and the rate of decrease in the liquid weight of the replacement fluid bag is detected using the first weighing scale. By continuously adjusting the speed of the first peristaltic pump, a curve showing the relationship between the actual speed of the first peristaltic pump and the rate of decrease in the liquid weight of the replacement fluid bag is plotted. The relationship curve is used to determine whether the first weighing scale and the first peristaltic pump are malfunctioning.

8. The blood purification device according to claim 1, characterized in that, The processor is used to execute the computer program and, when executing the computer program, to implement the following control method for the blood purification device: When the blood purification device is in the blood purification treatment stage, if an abnormal stop command is received, the first peristaltic pump and the first weighing scale are controlled to lose power and stop, and the theoretical weight reduction of the replacement fluid bag and the actual weight reduction of the replacement fluid bag are recorded at the same time. Determine the first weight reduction of the replacement fluid bag over a first preset time period, wherein the first preset time period is set based on the first theoretical rotational speed; If the theoretical weight reduction and the actual weight reduction meet the second preset condition, a seventh fault alarm signal will be issued. The second preset condition is: the absolute value of the difference between the theoretical weight reduction and the first weight reduction and the actual weight reduction is greater than the second preset weight.

9. A computer-readable storage medium, characterized in that, The computer-readable storage medium stores a computer program that, when executed by a processor, causes the processor to implement the control method of the blood purification device as described in any one of claims 1-8.

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