A graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes

Abstract

The present invention discloses a graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes, and relates to the technical field of medical supplies. The raw materials of the Chinese medicine composition include: 6-10 parts of Coix lacryma-jobi, 6-10 parts of Buddleja buddleja, 6-10 parts of Bidens pilosa, 6-10 parts of Angelica sinensis and 0.3 parts of Borneol. The present invention formulates the Chinese medicine composition formula in the hot compress eye patch according to the etiology and pathogenesis of dry eyes and in combination with the characteristics of the medicine. After repeated revisions and verifications, it has been widely used in the treatment of various types of dry eyes. Most patients have good feedback, satisfactory efficacy, and no side effects.

Description

Technical Field

[0001] The present invention relates to the technical field of medical supplies, and in particular to a graphene Chinese medicine hot compress eye patch for assisting in the treatment of dry eyes. Background Art

[0002] Dry eye is a multifactorial ocular surface disease characterized by tear film homeostasis imbalance and accompanied by ocular discomfort symptoms. Its main pathophysiological mechanisms are tear film instability, increased tear osmotic pressure, ocular surface inflammatory response and damage, and neural abnormalities. Since 2020, dry eye has been defined as a chronic ocular surface disease caused by multiple factors, and the concept of ocular surface microcirculation has been introduced. This new concept emphasizes the accumulation of disease formation and the long-term nature of the treatment process, clarifies that dry eye is a chronic disease, and explains that there are many factors that lead to dry eye. Even the same patient may be caused by multiple factors. This reflects the complexity of the cause of dry eye and brings difficulties to the treatment of dry eye. "Ocular surface microenvironment" is a concept proposed for the first time, emphasizing that the ocular surface is a unified whole, relying on comprehensive factors such as tears, cells, nerves and immunity to maintain balance. Once one or more factors are out of balance, it may cause a series of chain reactions on the ocular surface, leading to an imbalance of ocular surface function. This coincides with the thinking mode of traditional Chinese medicine that emphasizes the holistic concept.

[0003] The high osmotic pressure of tears begins with a decrease in tear secretion and a thinning of the tear film, which is aggravated by a shortened tear film breakup time. Changes in tear osmotic pressure are not the starting point of dry eyes, but the core link in the pathogenesis of dry eyes, which can trigger a series of chain reactions. Any cause of dry eyes may be an entry point for increased tear osmotic pressure, such as ocular surface inflammatory reactions caused by ocular allergic diseases, ocular surface toxic reactions caused by local long-term application of preservative-containing eye drops, and mucin abnormalities caused by conjunctival goblet cell loss. High osmotic pressure tears contain some inflammatory reaction mediators, such as prostaglandins, cytokines, and neurokinases. These components can promote apoptosis of corneal cells, conjunctival epithelial cells, and goblet cells, further reducing tear secretion and mucin secretion, increasing glycoprotein degradation, and then aggravating tear film instability, causing dry eyes to enter a vicious cycle.

[0004] The main clinical symptoms of dry eyes are vision fluctuations and eye discomfort, including dry eyes, eye fatigue, foreign body sensation, burning sensation, photophobia, stinging, etc. The patient's pain and the degree of impact on the quality of life are closely related to the severity of the symptoms. Tear hyperosmotic pressure is the main cause of eye symptoms and is also related to the specific cause of the disease. In the early stages of dry eyes, symptom attacks are intermittent and self-healing. The body uses a compensatory mechanism, namely blinking, to compensate for the effects of dry eyes on the ocular surface, and increases tear secretion to relieve the dryness of the ocular surface and delay the progression of the disease. However, as the disease worsens, the decrease and loss of corneal sensitivity will cause the loss of the compensatory mechanism, leading to damage to the ocular surface and the formation of a chronic disease that cannot self-repair, eventually entering a vicious cycle.

[0005] There are many treatments for dry eyes, but currently the main treatment is symptomatic treatment to improve dry eye symptoms, such as various artificial tears and lacrimal punctum embolism, wet chamber mirrors, hot compress packs, etc. Some treatments targeting the cause of dry eyes, such as cleaning the eyelid margin, removing mites, meibomian gland massage, and OPT treatment, have good effects on dry eyes caused by meibomian gland dysfunction and Demodex blepharitis, but the cause of dry eyes is complex, and even the same patient may be the result of multiple factors. In addition, the long course of dry eyes brings great difficulties to treatment. Traditional Chinese medicine can better relieve the clinical symptoms of patients in the treatment of dry eyes. Syndrome differentiation and treatment, various acupuncture therapies, and external treatments such as mist fumigation can achieve satisfactory short-term effects. In the dry eye guidelines (DEWS II) formulated by the International Tear Film and Dry Eye Society in 2017, the efficacy of acupuncture therapy in the treatment of dry eyes was clarified; in the 2020 consensus of dry eye experts in my country, the role of traditional Chinese medicine in the treatment of dry eyes was affirmed. However, the current types of traditional Chinese medicine hot compress eye patches are single and cannot meet the selection needs of consumers. Summary of the invention

[0006] Based on the above content, the present invention provides a graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes according to the etiology and pathogenesis of dry eyes and combined with the characteristics of the medicine, which has the advantages of good efficacy and no side effects.

[0007] To achieve the above object, the present invention provides the following solutions:

[0008] One of the technical solutions of the present invention is a traditional Chinese medicine composition for treating dry eyes by external application, the raw materials of which include: 6-10 parts of Herba Corydalis, 6-10 parts of Buddleja Flos, 6-10 parts of Bidens pilosa, 6-10 parts of Angelica sinensis and 0.3 parts of Borneol.

[0009] The above-mentioned Chinese medicine composition is the result of repeated experiments and summaries by the inventor in long-term clinical practice. Since the use of Chinese medicine atomization in 2018 and Chinese medicine hot compress packs in 2020, the inventor believes that in order to quickly relieve dry eye symptoms, especially discomfort symptoms such as eye pain and foreign body sensation, it is necessary to relieve local inflammation and neuralgia of the eye as the main target, especially inflammation is the core link of dry inflammation. Combining the etiology and pathogenesis of dry eyes and the efficacy characteristics of Chinese medicine, the inventor believes that the pharmaceutical composition with the effects of dispelling wind and heat, purging fire and detoxifying, clearing the liver and improving eyesight, nourishing blood and relieving pain, and promoting blood circulation and removing blood stasis can achieve the above therapeutic purposes. This is because: First, Chinese medicine believes that "pain occurs when there is no circulation" or pain occurs when there is cold and blood stasis, so drugs with nourishing blood and promoting blood circulation, warming meridians and removing blood stasis can achieve a good analgesic effect. Secondly, most of the Chinese medicines with the effects of dispelling wind and heat, purging fire and detoxifying have anti-inflammatory and antioxidant effects. Finally, since Chinese medicine hot compress eye patches mainly act on the eyes, Chinese medicines with the effects of clearing heat and detoxifying and clearing the liver and improving eyesight are more suitable. To this end, in combination with the above analysis and literature, the present invention preliminarily selected more than 20 alternative drugs, optimized the combination and made into a Chinese medicine bag with non-woven fabric as external material and built-in rough processed Chinese medicine slices, which was used in the department. During use, the inventor found that most patients had a higher acceptance of drugs with fragrant smell and non-irritating. To this end, the inventor selected 12 drugs including chrysanthemum, honeysuckle, schizonepeta tenuifolia, buddlejac, selfheal, bidens pilosa, mint, chuanxiong, angelica, notopterygium, siler, and scutellaria. On the basis of achieving the effects of dispelling wind and clearing heat, purging fire and detoxifying, clearing the liver and improving eyesight, nourishing blood and relieving pain, and promoting blood circulation and removing blood stasis, a variety of different formula combinations were tried. In the repeated clinical use process, it was found that the Chinese medicine composition of the present invention had the highest patient acceptance, the best experience feeling, and the best efficacy.

[0010] The second technical solution of the present invention is a method for preparing the above-mentioned Chinese medicine composition for treating dry eyes by external application, comprising the following steps:

[0011] The other raw materials except borneol are mixed evenly and then crushed, and then borneol is added and mixed evenly to obtain the traditional Chinese medicine composition for treating dry eyes by external application.

[0012] Furthermore, the powder is crushed to a particle size of no more than 100 μm.

[0013] If the particle size is too large, the efficacy of traditional Chinese medicine will be difficult to exert during the hot compress process; if the particle size is too small, the energy consumption and manpower of grinding the medicine will increase. Considering the efficacy and energy consumption, the present invention preferably limits the crushing to a particle size of no more than 100 microns.

[0014] The third technical solution of the present invention is a graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes, which contains the above-mentioned Chinese medicine composition for treating dry eyes by external application, and a non-woven fabric containing graphene.

[0015] Furthermore, the eye patch has a double-layer structure, the outer layer is a heat-generating material, and the inner layer is the above-mentioned Chinese medicine composition.

[0016] Furthermore, the dosage of the Chinese medicine composition in the eye patch corresponding to the left and right eyes is 2g respectively.

[0017] Furthermore, the non-woven fabric on the side of the eye patch that contacts the eye skin is made of graphene medical-grade non-woven fabric.

[0018] The present invention is based on the clinical characteristics of dry eyes and the etiology and pathogenesis of traditional Chinese medicine, combined with many years of clinical experience, and selects traditional Chinese medicines with aromatic smell, liver-clearing and eye-improving, blood-nourishing and blood-activating properties to carefully develop a traditional Chinese medicine formula. The formula is mainly used to make traditional Chinese medicine hot compress eye patches, which can be used to make ordinary hot compress eye patches, and can also be used to make graphene traditional Chinese medicine hot compress eye patches with more stable heat conduction and longer hot compress time, and can also make other types of hot compress eye patches. The present invention is suitable for the auxiliary treatment of various types of dry eyes with dry eyes, eye fatigue, eye pain, eye swelling, stinging, photophobia, foreign body sensation, burning sensation, etc. as the main manifestations, especially the treatment of dry eyes with meibomian gland dysfunction as the main cause.

[0019] The Chinese medicine composition in the graphene Chinese medicine hot compress eye patch of the present invention is prepared by combining and preparing in proportion Herba Corydalis, Buddleja Buddleja, Herba Bidens, Angelicae Sinensis, and artificial borneol, and has the effects of dispelling wind and heat, purging fire and detoxifying, clearing the liver and improving eyesight, nourishing blood and relieving pain, promoting blood circulation and dispersing blood stasis, etc., and is used to treat various exogenous rheumatic heat and toxic evils, and ophthalmic diseases such as red and swollen eyes, itchy eyes, foreign body sensation, burning sensation, dryness and stinging discomfort caused by dysfunction of internal organs. Among them, Herba Corydalis and Herba Buddleja can dispel wind and heat, purge fire and detoxify, clear the liver and improve eyesight; Herba Bidens can clear heat and detoxify, disperse blood stasis and promote blood circulation, and Angelicae Sinensis can nourish blood, promote blood circulation and relieve pain. Borneol can improve eyesight and remove cataracts, open the orifices with fragrance, open the Xuanfu, and improve the bioavailability of other drugs. The extracts or active ingredients of Herba Corydalis, Herba Buddleja Buddleja, Herba Bidens have different degrees of therapeutic effects on dry eyes. Bidens pilosa can reduce the ocular surface inflammation of patients with dry eye and improve the subjective symptoms and clinical indicators of dry eye by affecting genes such as TNF, VEGFA, and IL-6, as well as regulating TLR signaling pathways, NF-κB signaling pathways, and MARK signaling pathways. Buddleja buddleja total flavonoids and buddleja buddleja extract can reduce inflammation of lacrimal gland tissue by inhibiting inflammatory-related factors and pathways, thereby achieving the purpose of treating dry eye. Borneol can remove mites and inhibit bacteria, and can also promote the absorption of drugs and improve the bioavailability of drugs.

[0020] The present invention formulates the Chinese medicine formula in the above-mentioned hot compress eye patch according to the etiology and pathogenesis of dry eyes and in combination with the characteristics of the medicine. After repeated revisions and verifications, it has been widely used in the treatment of various types of dry eyes. Most patients have good feedback, satisfactory efficacy, and no side effects. In order to solve the needs of some patients to take away, the inventor cooperated with relevant departments to make the above-mentioned Chinese medicine formula into a Chinese medicine hot compress eye patch, and conducted a questionnaire survey and dry eye efficacy evaluation on the test population. Most of the subjects believed that this product has a suitable fragrance, moderate heat, long hot compress effect time, and satisfactory efficacy.

[0021] The present invention discloses the following technical effects:

[0022] (1) The present invention uses an eye patch to "directly reach the affected area", which is beneficial for relieving dry eye symptoms: the Chinese medicine composition in the hot compress eye patch of the present invention is composed of Herba Corydalis, Buddleja Buddleja, Herba Bidens, Angelicae Sinensis and artificial borneol. The combination of these medicines can play the role of dispelling wind and heat, purging fire and detoxifying, clearing the liver and improving eyesight, nourishing blood and relieving pain, promoting blood circulation and dispersing blood stasis, etc., which is in line with the pathogenesis of dry eyes and can effectively relieve dry eyes caused by dry eyes. Eye pain, eye fatigue, soreness, burning sensation, foreign body sensation and other discomfort. Modern medicine believes that dry eyes are mainly caused by increased tear osmotic pressure, unstable tear film and local inflammation. Herba Corydalis and Herba Buddleja can dispel wind and heat, purge fire and detoxify, clear the liver and improve eyesight and remove cataracts, and Herba Bidens can clear heat and detoxify, disperse blood stasis and promote blood circulation. It not only has anti-inflammatory and antioxidant effects, but also can improve the stability of tear film. Directly acting on the periphery of the eye, it can effectively and quickly relieve dry eye symptoms such as dry eyes, stinging, burning sensation, foreign body sensation, etc., reflecting the advantages of external treatment of traditional Chinese medicine ophthalmology. Angelica sinensis nourishes blood, activates blood circulation and relieves pain. With the help of hot compress, it can not only promote local blood circulation and increase oxygen supply, but also accelerate metabolism and promote the restoration of the balance of the ocular surface microenvironment. At the same time, these drugs act directly on the eyes without the "first-pass effect" of the liver, avoiding possible side effects.

[0023] (2) The hot compress eye patch of the present invention is reasonably designed: the graphene Chinese medicine hot compress eye patch provided by the present invention is a double-layer structure, the outer layer is a heat-generating object, and the Chinese medicine mixture is located in the inner layer; through the heating of the outer layer and its thermal conduction effect, the heat energy can be effectively conducted to the eyes, and the discomfort of the eyes caused by the rapid heating of the heat-generating object and excessive temperature can be avoided. At the same time, because the graphene component is sprayed on the outer layer of the eye patch, the action time of the hot compress eye patch can be effectively stabilized, which can prolong the action time of the Chinese medicine and maximize the effect of the medicine, thereby effectively alleviating the symptoms of dry eyes. In addition, with the help of thermal conduction, the steam (active substance) and fragrance of the Chinese medicine can be better transported to the eyes continuously. Since the medicine of this formula has the characteristics of fragrant smell and moderate fragrance, if the patient experiences it quietly, it can also make the mood relaxed and the spirit happy.

[0024] (3) The graphene Chinese medicine hot compress eye patch of the present invention has the characteristics of uniform heat transmission and long-lasting heat generation: due to the stable and fast thermal conductivity of graphene, the graphene hot compress eye patch can reduce heat loss and maintain continuous heat generation for a longer period of time, and the heat transmission of each part of the eye patch is also relatively uniform. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0026] Figure 1 This is a working principle diagram of the graphene Chinese medicine hot compress eye patch of the present invention;

[0027] Figure 2 This is a physical picture of the graphene Chinese medicine hot compress eye patch prepared in Example 1;

[0028] Figure 3 The following are actual pictures of the eye patches of type A and type C used in the examples for verifying the effects of the present invention. DETAILED DESCRIPTION

[0029] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0030] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0031] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0032] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to the skilled artisan. The present invention description and examples are exemplary only.

[0033] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0034] Unless otherwise specified, the "parts" described in the present invention are all based on mass parts.

[0035] Unless otherwise specified, the raw materials used in the embodiments of the present invention can be obtained through commercial channels.

[0036] The working principle of the graphene Chinese medicine hot compress eye patch of the present invention is as follows Figure 1 shown.

[0037] Example 1

[0038] Accurately weigh 8 parts of Herba Corydalis, 8 parts of Buddleja Buddleja, 8 parts of Herba Bidens and 8 parts of Angelicae Sinensis, mix and stir, then use a Chinese medicine grinder to grind the above drug mixture and filter it with a filter screen with a diameter of 2 mm, remove the coarse residue and grind it again until the drug is completely crushed to a particle size of 100 μm, add 0.3 parts of finely crushed artificial borneol particles and mix evenly to obtain a Chinese medicine composition, which is divided into several portions with a mass of 2g after disinfection and sterilization, and each hot compress eye patch uses 4g of the Chinese medicine composition (2g for each left and right eye), and adds the inner layer of the hot compress eye patch. The hot compress eye patch is divided into two layers, the outer layer is composed of a heating material (a mixture of iron powder, edible salt, and activated carbon in a mass ratio of 1:2:1), and the inner layer is composed of the above Chinese medicine composition. The non-woven fabric on the side of the skin contacting the eye is a graphene medical grade non-woven fabric, which is then packaged and formed to obtain a graphene Chinese medicine hot compress eye patch, which is packaged with tin foil for standby use.

[0039] The actual picture of the graphene Chinese medicine hot compress eye patch prepared in this embodiment is as follows: Figure 2 As shown, Figure 2 In the figure, the left picture shows the finished product of the graphene Chinese medicine hot compress eye patch, and the right picture shows the placement of the heating material and the Chinese medicine composition in the graphene Chinese medicine hot compress eye patch. The inner layer of brown powder is the Chinese medicine composition, and the outer layer of black powder is the heating material.

[0040] Effect verification example

[0041] 1. Questionnaire survey and analysis of graphene Chinese medicine eye patch

[0042] 1.1 Research Method: This study adopted a crossover experimental design method, and included 30 patients. Each patient received two eye patches, A and C (see the actual picture). Figure 315 patients were treated with Type A eye patch first, and the other 15 patients were treated with Type C eye patch first; after using for 1 week, they rested for 3 days, and then used another type of hot compress eye patch respectively. All patients were blinded during the experiment, that is, they were unaware of the specific composition of the A / C eye patches. (Note: Type A eye patch is the graphene Chinese medicine hot compress eye patch prepared in Example 1, and Type C eye patch is a pure graphene hot compress eye patch, which differs from Example 1 only in that no Chinese medicine composition is added). Fill out the questionnaire after use.

[0043] The method of using the graphene Chinese medicine hot compress eye patch of the present invention is as follows: after taking it out, apply it directly to the eyes, and fix it on the auricle with the non-woven fabric hanging rope attached to the eye patch. During use, try to be calm and fully enjoy the fragrance of the Chinese medicine. It is usually used for 20 minutes, but because the surface layer of this product is made of graphene material with a longer lasting hot compress time and a more uniform thermal conductivity effect, it can maintain a longer fever time. Some critically ill patients can continue to use it for 30-40 minutes.

[0044] 1.2 The questionnaire consists of 10 questions, among which questions 1-4 compare and analyze the differences between the two graphene hot compress eye patches in terms of comfort, temperature, heating uniformity, and overall satisfaction; questions 5-9 compare the two hot compress eye patches in terms of overall efficacy, fragrance, hot compress duration, purchase and recommendations, etc.; question 10 is suggestions and opinions on the product.

[0045] (1) Basic information of patients: A total of 30 patients were included in the survey, including 3 males and 27 females, aged 17-66 years (mean, (33.43±9.75) years), and OSDI score for dry eye (24.92±9.24).

[0046] (2) After patients used eye patches A and C, the overall comfort, temperature suitability, heating uniformity, and overall satisfaction were compared. The overall comfort, temperature suitability, heating uniformity, and overall satisfaction of both groups were high, but the comfort and satisfaction of eye patch A were better. The results are as follows:

[0047] Table 1 compares the overall comfort, temperature suitability, heating uniformity, and overall satisfaction of the eye patches A and C.

[0048] Table 1 Comparison of satisfaction with Chinese medicine hot compress eye patch

[0049]

[0050] In the table, T is the statistical value calculated by the T test for two groups of data, P is the statistical probability, and P < 0.05 indicates statistical difference.

[0051] (3) After patients used eye patches A and C, they were asked to complete a questionnaire survey on the duration of action, overall efficacy, scent, and purchase recommendations. The results are as follows.

[0052] ① The duration of action of the two eye patches: The two patches were similar in 70% (21 cases), Type A was longer in 10% (3 cases), and Type C was longer in 20% (6 cases);

[0053] ②Comparison of overall effects: 56.6% (17 cases) thought that Type A was better, 27.7% (8 cases) thought that Type C was better, and 16.7% (5 cases) thought that the two types were similar.

[0054] ③ Acceptance of the two scents: 73.3% (22 cases) of scent A, 20% (6 cases) of scent C; 6.7% (2 cases) of the two scents were similar;

[0055] ④ Demand for fragrance improvement: Among the patients who agreed with Type A eye patch (22 cases, 73.3%), 22.7% (5 cases) thought that Type A was lighter, and 77.3% (17 cases) thought that it was suitable; among the patients who agreed with Type C eye patch (6 cases, 20%), 50% (3 cases) thought that Type C was stronger, and 50% (3 cases) thought that it was suitable;

[0056] ⑤ Purchase intention: 30% (9 cases) said they would buy Model A more than Model A, 60% (18 cases) said they would buy Model C more than Model C, and 10% (3 cases) said they would buy Model C more than Model A.

[0057] ⑥Other suggestions: 3 cases thought that Type A had too strong a medicinal smell; 2 cases thought that it was not well fitted; and 1 case thought that it was difficult to fix.

[0058] 2. Analysis of the efficacy of graphene Chinese medicine hot compress eye patch in treating MGD (meibomian gland dysfunction) related dry eyes

[0059] This effect verification example is a randomized controlled study, which aims to observe the efficacy of the graphene Chinese medicine hot compress eye patch prepared in Example 1 in the auxiliary treatment of MGD-related dry eyes. A total of 60 volunteer subjects were recruited for the study, and they were divided into a graphene Chinese medicine hot compress eye patch + sodium hyaluronate eye drops treatment group (hereinafter referred to as the treatment group) and a simple graphene hot compress eye patch + sodium hyaluronate eye drops treatment group (hereinafter referred to as the control group) by random number method, with 30 cases in each treatment group and control group. There were 5 males and 25 females in the treatment group, aged 21 to 66 years old, with an average age of (33.83 ± 9.28) years old, a course of 2 to 48 months, and an average of (18.57 ± 13.25) months; there were 7 males and 23 females in the control group, aged 23 to 66 years old, with an average age of (33.53 ± 8.83) years old, a course of 2 to 48 months, and an average of (15.86 ± 12.60) months. The data were compared between the two groups, and there was no statistically significant difference. The treatment group and the control group used hot compress eye patches once a day for 15 minutes each time; sodium hyaluronate eye drops were used 4 times a day. No other drugs or physical therapy such as meibomian gland massage were used during the treatment. After 1 month of follow-up, the OSDI score, BUT, and SIT scores were used as observation indicators to evaluate the efficacy of the two groups. The OSDI score was scored using the Chinese OSDI score table; BUT used the corneal fluorescein staining method under the slit lamp to observe the tear film breakup time, and the measurement was performed continuously for 3 times to calculate the average value; SIT was measured using Shimmer test paper, and the Shimmer test paper was placed in the middle and outer 1 / 3 of the lower eyelid, and the tear secretion value was measured for 5 minutes. After 4 weeks of treatment, the changes in OSDI scores, BUT, and SIT of the two groups of patients were as follows:

[0060] (1) Comparison of OSDI score changes before and after treatment between the two groups: The changes in OSDI scores between the two groups before and after treatment are shown in Table 2. After the treatment course, the OSDI scores between the two groups before and after treatment were compared by T test, and the differences were statistically significant (P<0.01). The OSDI difference between the two groups before and after treatment was compared by T test, and the difference was statistically significant (P<0.01), indicating that the treatment group had better efficacy, and the graphene Chinese medicine hot compress eye patch of this formula can relieve the clinical symptoms of MGD-related dry eye patients to a greater extent.

[0061] Table 2 Comparison of OSDI scores between the two groups before and after treatment

[0062]

[0063] (2) Comparison of BUT changes before and after treatment in the two groups: The changes in BUT before and after treatment in the two groups are shown in Table 3. After the treatment course, the changes in BUT before and after treatment in the two groups were compared by T test, and the differences were statistically significant (P<0.01). The difference in BUT before and after treatment in the two groups was compared by T test, and the difference was statistically significant (P<0.05), indicating that the treatment group had better efficacy, and the graphene Chinese medicine hot compress eye patch prepared in Example 1 could improve the tear film stability of patients with MGD-related dry eyes to a greater extent.

[0064] Table 3 Comparison of BUT changes between the two groups before and after treatment

[0065]

[0066] (3) Comparison of SIT changes before and after treatment between the two groups: The changes in SIT before and after treatment between the two groups are shown in Table 4. After the treatment course, the changes in SIT before and after treatment between the two groups were compared by T test. The difference between the treatment group and the control group was statistically significant (P<0.01), and the difference was statistically significant (P<0.05). The difference in SIT before and after treatment between the two groups was compared by T test. The difference was not statistically significant. This shows that both groups can improve the amount of tear secretion, and the graphene Chinese medicine hot compress eye patch of this formula has a better therapeutic effect.

[0067] Table 4 Comparison of changes in SIT scores between the two groups before and after treatment

[0068]

[0069] It can be seen from Tables 2-4 that the graphene Chinese medicine hot compress eye patch prepared in Example 1 combined with artificial tears (sodium hyaluronate eye drops) for the treatment of MGD-related dry eyes can more significantly improve the patient's clinical symptoms and tear film stability, and the therapeutic effect is better than that of simple graphene hot compress eye patch combined with artificial tears.

[0070] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicine composition for treating dry eyes by external application, characterized in that: The raw materials are: 6-10 parts of Herba Corydalis, 6-10 parts of Buddleja Soft, 6-10 parts of Bidens Piperis, 6-10 parts of Angelica Sinensis and 0.3 parts of Borneol.

2. A method for preparing the Chinese medicine composition for treating dry eyes by external application according to claim 1, characterized in that: The following steps are involved: The other raw materials except borneol are mixed evenly and then crushed, and then borneol is added and mixed evenly to obtain the traditional Chinese medicine composition for treating dry eyes by external application.

3. The preparation method according to claim 2, characterized in that: Grind to a particle size no greater than 100 μm.

4. A graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes, characterized in that: A non-woven fabric containing the Chinese medicinal composition for treating dry eyes by external application as claimed in claim 1, and graphene.

5. The graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes according to claim 4, characterized in that: The eye patch has a double-layer structure, the outer layer is a heating material, and the inner layer is the Chinese medicine composition according to claim 1.

6. The graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes according to claim 4, characterized in that: The dosage of the Chinese medicine composition in the corresponding parts of the left and right eyes in the eye patch is 2g respectively.

7. The graphene Chinese medicine hot compress eye patch for auxiliary treatment of dry eyes according to claim 4, characterized in that: The non-woven fabric on the side of the eye patch that contacts the eye skin is made of graphene medical-grade non-woven fabric.

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