A kind of antipyretic Chinese medicine composition for treating fever caused by viral infection and its preparation method and application

Abstract

The present invention discloses a fever-reducing Chinese medicine composition for treating fever caused by viral infection, and its preparation method and application. The fever-reducing Chinese medicine composition is made of 5-20g of Artemisia annua, 5-20g of Bupleurum, 3-10g of Notopterygium wilfordii, 3-10g of Radix Ephedrae, 3-10g of Amomum villosum, 10-30g of Radix Trichosanthis, 5-20g of Flos Lonicerae and 5-20g of Fructus Forsythiae. The above-mentioned Chinese medicine composition is used to alleviate and treat fever caused by viral infection, especially fever caused by pulmonary viral infection, or fever caused by novel coronavirus infection, and has significant curative effect.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and more specifically, to a fever-reducing traditional Chinese medicine composition for treating fever caused by viral infection, and a preparation method and application thereof. Background Art

[0002] Fever is a relatively common symptom. Infectious fever is caused by bacteria, viruses, mycoplasma pneumoniae, rickettsia, fungi, spirochetes, etc. invading the human body. Fever caused by viral infection is characterized by high fever and persistence. The main symptoms of most patients infected with the 2019 novel coronavirus (SARS-CoV-2, referred to as the new coronavirus in this article) include fever, fatigue, dry cough, etc. Among them, fever has the characteristics of high fever, long duration, and higher fever at night.

[0003] Modern medicine mainly treats fever with non-steroidal anti-inflammatory drugs, including ibuprofen and acetaminophen. Ibuprofen is a non-selective COX inhibitor with obvious anti-inflammatory, antipyretic and analgesic effects. It has an antipyretic effect through the hypothalamic temperature regulation center. Acetaminophen is an acetanilide antipyretic and analgesic. 80% of cold medicines contain acetaminophen, such as Sanlitong, Tylenol, Gankang, Vitamin C Yinqiao Tablets, etc. However, these drugs do not have a thorough antipyretic effect, and the fever is prone to recurrence again and again. In addition, these drugs are prone to cause adverse reactions such as gastrointestinal reactions, and drug overdose can easily lead to liver and kidney damage. There are also some problems with children's antipyretic drugs, such as incomplete antipyretic effect, repeated fever, excessive sweating, gastrointestinal irritation, etc.

[0004] Therefore, it is very important to develop a Chinese medicine composition that has no adverse reactions, can significantly reduce the body temperature of patients infected with the virus, especially those with fever caused by the new coronavirus, and has a complete and non-recurrent antipyretic effect and significantly improves clinical symptoms. Summary of the invention

[0005] In response to the above technical problems, the first object of the present invention is to provide a new antipyretic Chinese medicine composition, which is used to relieve and treat fever caused by viral infection, especially fever caused by lung viral infection, or fever caused by new coronavirus infection, and has obvious efficacy.

[0006] The second object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition.

[0007] The third object of the present invention is to provide a medicine using the above-mentioned Chinese medicine composition as an effective active ingredient.

[0008] The fourth object of the present invention is to provide the use of the above-mentioned Chinese medicine composition in the preparation of a medicine for treating fever caused by viral infection.

[0009] In order to achieve the above object, the present invention adopts the following technical solutions:

[0010] In a first aspect, the present invention provides an antipyretic Chinese medicine composition for treating fever caused by viral infection, which is prepared from 5-20g of Artemisia annua, 5-20g of Bupleurum chinense, 3-10g of Notopterygium wilfordii, 3-10g of roasted Ephedra sinica, 3-10g of Amomum villosum, 10-30g of Radix Trichosanthis, 5-20g of Honeysuckle and 5-20g of Forsythia suspensa.

[0011] In the prescription of the present invention, the following are the functions and effects of each component:

[0012] Artemisia annua: bitter, pungent, cold. Enters the liver and gallbladder meridians. It has the effects of clearing away heat from the deficiency, removing bone steaming, relieving summer heat, stopping malaria, and relieving jaundice. It can be used to treat Yin damage caused by pathogenic heat, night heat and morning coolness, Yin deficiency fever, bone steaming and fatigue fever, exogenous summer heat, fever and thirst, malaria and cold and heat, etc. Pharmacological studies have shown that Artemisia annua has a significant antimalarial effect. The effective ingredients contained in it, such as artemisinin, β-sitosterol, and stigmasterol, have antiviral effects, and have choleretic, antipyretic, analgesic, anti-inflammatory, and anti-tumor effects. The volatile oil has antitussive, expectorant, and antiasthmatic effects.

[0013] Bupleurum: pungent, bitter, slightly cold. It enters the liver, gallbladder, and lung meridians. It can relieve fever, relieve liver depression, and raise Yang Qi. It can be used to treat colds and fever, alternating colds and heat; liver depression and qi stagnation, chest and flank pain, irregular menstruation; qi deficiency and sinking, uterine prolapse, and rectal prolapse. Experimental studies have shown that Bupleurum decoction, injection, alcohol extract, volatile oil, and crude saponin have obvious antipyretic effects on experimental fever caused by various animals, and can reduce the body temperature of normal animals. Bupleurum and its active ingredient, saikosaponin, have anti-inflammatory effects.

[0014] Qianghuo: pungent, bitter, warm. Enters the bladder and kidney meridians. It has the functions of dispelling cold, expelling wind and dampness, and relieving pain. It can treat colds, headaches, stiff necks, cold and dampness, shoulder and back pain, etc. Modern pharmacological studies have shown that Qianghuo has anti-inflammatory, analgesic and antipyretic effects. Qianghuo volatile oil can counteract myocardial ischemia caused by posterior pituitary hormone and increase nutritional blood flow for palpitations.

[0015] Ephedra: pungent, slightly bitter, warm. Enters the lung and bladder meridians. Has the effects of diaphoresis, relieving asthma, promoting diuresis and reducing swelling. Can treat colds, chest tightness, cough, edema, cold and dampness. Modern pharmacology indicates that ephedra decoction, ephedra volatile oil, ephedrine, methylephedrine, etc. have diaphoretic effects. Experimental studies have shown that ephedra volatile oil has antipyretic effects on a variety of experimental fever model animals.

[0016] Tsaoko: pungent, warm. Enters the spleen and stomach meridians. Has the effects of drying dampness, warming the middle, stopping malaria and removing phlegm. Pharmacological studies have shown that the α- and β-pinene contained in it have antitussive and expectorant effects, among which β-pinene has a strong anti-inflammatory and antifungal effect.

[0017] Radix Trichosanthis: sweet, slightly bitter, slightly cold. Enters the lung and stomach meridians. It has the effects of clearing away heat and purging fire, promoting fluid and quenching thirst, and reducing swelling and draining pus. It can be used to treat fever, thirst, lung heat and dry cough, internal heat and thirst, sores and swelling. Radix Trichosanthis protein can enhance the human immune response, and Radix Trichosanthis polysaccharide can enhance immune activity.

[0018] Honeysuckle: sweet and cold. Enters the lung, heart and stomach meridians. It has the effects of clearing away heat and detoxifying, and dispersing wind-heat. It can be used to treat wind-heat colds, fever caused by febrile diseases, carbuncles, furuncles, throat paralysis, erysipelas, and dysentery caused by heat and toxicity. Experiments have shown that the chlorogenic acid compounds and other ingredients contained in honeysuckle have a certain inhibitory effect on various pathogenic bacteria such as Staphylococcus aureus, hemolytic streptococci, Shigella dysenteriae, and Vibrio cholerae, and have a certain effect on influenza virus and Coxsackie virus.

[0019] Forsythia: bitter, slightly cold. Enters the lung, heart, and small intestine meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing stagnation, and evacuating wind-heat. It can be used to treat wind-heat colds, the beginning of febrile diseases, warm and hot entering the camp, high fever and thirst, coma and spots, carbuncle, scrofula, breast carbuncle, erysipelas, hot stranguria and astringent pain, etc. Experimental studies have shown that the decoction of Forsythia has a broad-spectrum antibacterial effect, and has a significant inhibitory effect on a variety of Gram-positive and Gram-negative bacteria. Its methanol extract also has anti-inflammatory and analgesic effects.

[0020] The virus is highly contagious. In the early stage after infection, headache, body pain, joint pain, aversion to cold, no sweating, and fever are common. They belong to the syndrome of wind-cold binding externally, which is on the surface of the Taiyang meridian. The tongue of this disease is often seen as thick white tongue coating, and the symptoms are often muscle soreness, which belongs to the syndrome of dampness blocking the Yangming meridian. The external evil can easily enter the interior and turn into heat, and quickly enter the Yangming meridian, which belongs to the syndrome of Yangming internal heat, which is on the interior of the Yangming meridian. The fever of this disease is characterized by light during the day and heavy at night, persistent heat, and alternating cold and heat, which belongs to the characteristics of evil hiding in Shaoyang and membrane origin, which is on the half-exterior and half-interior of Shaoyang. Comprehensive analysis shows that those who are infected with the virus and cause the three Yang diseases must be treated from Shaoyang. Therefore, Artemisia annua is the main herb. Artemisia annua is bitter, pungent, and cold, and has the energy of spring life. It has the ability to disperse, can promote the flow of qi and transform dampness, and can clear and resolve the exterior and reduce fever. Its antipyretic effect has the characteristics of a wide range of applications, rapid antipyretic, long-lasting effect, and thorough treatment. It has a significant antipyretic effect on fever caused by various viral infections. Bupleurum is bitter and slightly cold. The Shennong's Herbal Classic says that Bupleurum is "bitter and flat. It is used to treat the heart and abdomen, remove gas in the stomach and intestines, food accumulation, cold and heat evil qi, and remove the old and bring in the new." It can dissipate and reduce fever, and reconcile the Shaoyang. It can not only reconcile and reduce fever, but also dissipate heat and clear away excess heat. Ephedra is pungent and warm, and it belongs to the lung and bladder meridians. It can induce sweating, dissipate cold, and dissipate the evil of the sun. When sweating, the fever subsides. Notopterygium is pungent and warm, dissipates cold and relieves pain, and can also dissipate the sun. Bupleurum, ephedra, and notopterygium can dissipate cold, reconcile and reduce fever, and can not only dissipate the evil of the sun, but also dissipate the evil of the Shaoyang. They are all ministers. Amomum villosum is pungent and warm, and can dry dampness and warm the middle. It is specialized in transforming dampness, dissipating the evil of the Yangming, and clearing the Yangming bowels, so that dampness and heat are separated, and the heat evil is easier to retreat. Trichosanthes is heat-clearing and fire-purging, promoting fluid and quenching thirst, and is specialized in clearing the heat of the Yangming. Honeysuckle is sweet and cold, and can clear away heat and detoxify, and evacuate wind-heat. Forsythia suspensa is bitter and slightly cold, and can clear away heat and detoxify, and reduce swelling and resolve knots. The four are adjuvants. The combination of these medicines can disperse the evil of the sun externally, and clear the heat and dampness of the yangming internally, and harmonize the evil of the Shaoyang half-exterior and half-interior, and play the role of removing dampness and relieving exterior symptoms, clearing heat and detoxifying, and is mainly used to treat fever caused by viral infection.

[0021] Exemplarily, based on weight parts, the antipyretic Chinese medicine composition of the present invention is made of 20g of Artemisia annua, 20g of Bupleurum chinense, 10g of Notopterygium wilfordii, 10g of roasted Ephedra sinica, 10g of Amomum villosum, 30g of Radix Trichosanthis, 20g of Honeysuckle and 20g of Forsythia suspensa.

[0022] Exemplarily, based on weight, the antipyretic Chinese medicine composition is made of 15g of Artemisia annua, 15g of Bupleurum chinense, 9g of Notopterygium wilfordii, 9g of roasted Ephedra sinica, 7g of Amomum villosum, 30g of Radix Trichosanthis, 20g of Flos Lonicerae and 20g of Fructus Forsythiae.

[0023] Exemplarily, based on weight parts, the antipyretic Chinese medicine composition is made of 6g of Artemisia annua, 6g of Bupleurum chinense, 3g of Notopterygium wilfordii, 3g of roasted Ephedra sinica, 3g of Amomum villosum, 9g of Radix Trichosanthis, 6g of Flos Lonicerae and 6g of Fructus Forsythiae.

[0024] The basic formula of each raw material medicine of the above-mentioned Chinese medicine composition of the present invention can be adjusted according to clinical symptoms on the basis of the above-mentioned Chinese medicine composition in a specific embodiment to achieve the purpose of reducing fever and improving certain special clinical symptoms, further enhance the adaptability of the composition of the present invention, and improve the therapeutic effect. These adjustments made based on the basic formula of the present invention are also within the protection scope of this application.

[0025] In a second aspect, the present invention provides a method for preparing the above-mentioned antipyretic Chinese medicine composition for treating fever caused by viral infection, the preparation method comprising:

[0026] (1) Take Artemisia annua, Bupleurum chinense, Notopterygium wilfordii, roasted Ephedra sinica, Tsaoko, Radix Trichosanthis, Flos Lonicerae and Fructus Forsythiae according to the prescribed amount, add water and soak for 20 to 30 minutes;

[0027] (2) Cook over low heat until boiling and continue cooking for 15 to 20 minutes;

[0028] (3) Filter, add water to the residue and continue to boil for 15-20 minutes;

[0029] (4) Repeat step (3) 1-2 times and combine the filtrates;

[0030] or,

[0031] (1) crush Artemisia annua, Bupleurum chinense, Notopterygium wilfordii, roasted Ephedra sinica, Tsaoko, Radix Trichosanthis, Flos Lonicerae and Fructus Forsythiae according to the formula;

[0032] (2) mixing the crushed raw materials and extracting them with 70%-95% ethanol;

[0033] (3) Filter, recover ethanol under reduced pressure, concentrate, and dry to obtain the product.

[0034] Furthermore, for the convenience of storage, the above preparation method may further include the step of concentrating the filtrate obtained in step (4) into an extract; optionally, the extract is further dried to form powder.

[0035] In a third aspect, the present invention provides an antipyretic drug for treating fever caused by viral infection, wherein the drug comprises the above-mentioned Chinese medicine composition as an active ingredient.

[0036] According to actual needs, the drug may also include pharmaceutically acceptable adjuvants. According to conventional preparation processes, various preparations such as decoctions, granules, pills, capsules, tablets, powders, pastes or oral liquids may be prepared.

[0037] The present invention also provides the use of the above-mentioned antipyretic Chinese medicine composition in the preparation of a medicament for treating fever caused by viral infection; preferably, the fever caused by the viral infection is fever caused by pulmonary viral infection, or fever caused by novel coronavirus infection.

[0038] In addition, unless otherwise specified, the raw materials of the Chinese medicine composition of the present invention can be obtained commercially, and any range recorded in the present invention, including the end values ​​and any numerical value between the end values, and any sub-range of the Chinese medicine composition composed of the end values ​​or any numerical value between the end values, can achieve the purpose of reducing fever.

[0039] The beneficial effects of the present invention are as follows:

[0040] The combination of the drugs of the present invention can play the functions of removing dampness and relieving exterior symptoms, clearing away heat and detoxifying, and can effectively improve the clinical symptoms such as fever and chills, sore throat, cough and sputum, dizziness, etc. after viral infection, and has a significant effect on the treatment of fever with three yang combined diseases as the main pathogenesis. In addition, the Chinese medicine composition of the present invention can also be used for children with fever caused by viral infection, and can relieve exterior symptoms and fever, remove dampness and detoxify, and quickly reduce the body temperature of the children without recurrence. DETAILED DESCRIPTION

[0041] In order to explain the present invention more clearly, the present invention is further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the following specific description is illustrative rather than restrictive, and should not be used to limit the scope of protection of the present invention.

[0042] Example 1

[0043] Raw material medicine formula: Artemisia annua 15g, Bupleurum 15g, Notopterygium wilfordii 9g, roasted Ephedra 9g, Amomum villosum 6g, Radix Trichosanthis 30g, Honeysuckle 15g and Forsythia suspensa 15g.

[0044] Mix the above raw materials together, put them in a casserole, add water to cover the surface of the medicine, soak for 20 to 30 minutes, then decoct with a slow fire, continue to decoct for 15 to 20 minutes after boiling, filter, add water to the residue and decoct for 15 to 20 minutes, decoct three times in total, and combine the three filtrates to obtain a decoction. Instructions for use: decoction, one dose per day, decocted in water, once in the morning and evening, 7 days as a course of treatment.

[0045] Example 2

[0046] Raw material medicine formula: Artemisia annua 20g, Bupleurum 20g, Notopterygium wilfordii 10g, roasted Ephedra 10g, Amomum villosum 10g, Radix Trichosanthis 30g, Honeysuckle 20g and Forsythia suspensa 20g.

[0047] The above raw materials were crushed and mixed, and three times the weight of 95% ethanol was added, and ultrasonic extraction was performed for 1 hour; the residue was filtered, and the residue was ultrasonically extracted twice with three times the weight of 80% ethanol, each time for 1 hour; the three filtrates were combined, the ethanol was recovered under reduced pressure, concentrated, and dried to obtain an alcohol extract.

[0048] The above alcohol extract is made into tablets according to conventional preparation methods in the art.

[0049] Example 3

[0050] Raw material medicine formula: Artemisia annua 6g, Bupleurum 6g, Notopterygium wilfordii 3g, roasted Ephedra 3g, Amomum villosum 3g, Radix Trichosanthis 9g, Honeysuckle 6g and Forsythia suspensa 6g.

[0051] The above-mentioned raw materials are made into capsules according to conventional preparation methods in the art.

[0052] Example 4

[0053] A total of 60 patients with fever caused by respiratory viral infection who visited Guang'anmen Hospital of China Academy of Chinese Medical Sciences from September 2022 to December 2022 were included, including 30 patients in the Tuirefang granule group (the drug of the present invention) and 30 patients in the Lianhua Qingwen group.

[0054] The treatment of the Tuirefang granule group was as follows: prescription: Artemisia annua 15g, Bupleurum 15g, Notopterygium 9g, Ephedra sinica 9g, Tsaoko 6g, Radix Trichosanthis 30g, Flos Lonicerae 15g and Fructus Forsythiae 15g, prepared into granules by Guang'anmen Hospital according to the conventional granule preparation process, take 1 capsule each time, take once every 6 hours, and stop taking it when the fever subsides. The treatment of the Lianhua Qingwen group was as follows: Lianhua Qingwen capsule, 4 capsules each time, 3 times a day, oral, stop taking it when the fever subsides.

[0055] Inclusion criteria: patients with acute upper respiratory tract infection, influenza, novel coronavirus infection, body temperature ≥ 38.5℃, and who meet the following conditions and have no other serious systemic lesions can be selected. ① Patients with syndrome differentiation of three-yang combined disease; ② Peripheral blood WBC count ≤ 10×10 9 / L, neutrophil ≤70%; ③ Virus detection of nasopharyngeal secretions: (using alkaline phosphatase bridge enzyme labeling method) positive for influenza virus, new coronavirus, parainfluenza virus, and adenovirus; ④ Aged 15 to 55 years, seeking medical treatment within 24 hours of fever, and having not used antiviral Chinese or Western medicine.

[0056] Exclusion criteria: ① The wind-cold evil qi is in the Taiyang meridian and has not yet spread to the Yangming and Shaoyang meridians, and the patient has severe aversion to cold and mild fever; ② Fever caused by internal injuries; ③ Fever caused by bacterial infection.

[0057] Efficacy standards: The efficacy refers to the "Guidelines for Clinical Research of New Chinese Medicines (Trial)": The patient is cured if the body temperature and abnormal indicators return to normal and the symptoms disappear within 48 hours; the patient is markedly effective if the body temperature returns to normal and most symptoms disappear within 72 hours; the patient is effective if the body temperature drops and the main symptoms are alleviated within 72 hours; the patient is ineffective if the body temperature does not drop and the symptoms do not alleviate within 72 hours.

[0058] The baseline data of the two groups of patients, such as gender, age, body temperature, and onset time, were analyzed. The results showed that there was no difference in the baseline data between the two groups (P < 0.05), and the two groups were comparable.

[0059] Table 1 Clinical efficacy distribution table

[0060]

[0061] The results of clinical studies showed that the total effective rate of the Tuirefang granule group was 93.33%, and the total effective rate of the Lianhua Qingwen capsule group was 83.33%. There was no statistically significant difference in the total effective rate between the two groups. However, the research results show that the Tuirefang has a faster fever-reducing speed, and 73.33% of the patients can restore their body temperature to normal within 48 hours, indicating that the Tuirefang granule group has a better fever-reducing effect and can quickly lower the patient's body temperature.

[0062] Classic Case

[0063] Case 1

[0064] Li, male, 30 years old, was treated for "chills and high fever for more than 1 day". The patient had no obvious cause for aversion to cold and high fever 1 day ago, with an axillary temperature of 39.8℃. He took Lianhua Qingwen capsules orally and his fever subsided, but it came back soon. The self-test of the new crown antigen at home showed positive, so he went to our hospital for treatment and was determined to be infected with the new coronavirus. The current symptoms are: fever and chills, throat discomfort, occasional dry cough, fatigue and heaviness, cold extremities, red tongue, thick and greasy yellow fur, and floating pulse. The Chinese medicine antipyretic prescription of Example 2 of the present invention is given: 20g of Artemisia annua, 20g of Bupleurum, 10g of Notopterygium, 10g of roasted Ephedra, 10g of Tsaoko, 30g of Radix Trichosanthis, 20g of Honeysuckle and 20g of Forsythia. 7 doses, decocted in water, 1 dose per day, divided into 2g, 1g each morning and evening, taken with boiled water. After taking half a dose of the medicine, sweating and fever decreased, after taking one dose of the medicine, the body temperature dropped to 37℃, after taking two doses of the medicine, the body temperature returned to normal, and after taking three doses of the medicine, all symptoms disappeared.

[0065] Case 2

[0066] Zhang, female, 25 years old, was treated for "throat tingling and fever for more than three days". The patient had a sudden high fever and throat pain three days ago, with an axillary temperature of 39°C. She took vitamin C Yinqiao tablets by herself, and the throat pain was relieved after the medicine. Although the body temperature dropped, it did not heal repeatedly, so she was treated in our hospital. Current symptoms: repeated low fever, 37°C-38°C, sore throat, itchy throat, mild cough, dry and itchy throat at night, aggravated cough, red tongue with yellow greasy coating, and a weak pulse. The Chinese medicine antipyretic prescription of Example 2 of the present invention is given: 20g of Artemisia annua, 20g of Bupleurum, 10g of Notopterygium, 10g of roasted Ephedra, 10g of Tsaoko, 30g of Radix Trichosanthis, 20g of Honeysuckle and 20g of Forsythia, 3 doses, decocted in water, 1 dose per day, twice a day. After taking half a dose of the medicine, the body temperature returned to normal, the throat pain was relieved, and the cough was relieved.

[0067] Case 3

[0068] Liu, female, 37 years old, was treated for "throat tingling and fever for more than two days". The patient had a sudden high fever and throat pain two days ago, with an axillary temperature of 39.5℃. She took Lanqin oral liquid by herself, and the throat pain was relieved after the medicine, but the body temperature did not drop, so she was treated in our hospital. The current symptoms are: high fever is difficult to subside, sore throat, itchy throat, mild cough, dry and itchy throat at night, aggravated cough, red tongue with thick yellow fur, and a weak pulse. The Chinese medicine antipyretic prescription composition of Example 1 of the present invention is given: 15g of Artemisia annua, 15g of Bupleurum, 9g of Notopterygium, 9g of roasted Ephedra, 6g of Amomum villosum, 30g of Radix Trichosanthis, 15g of Honeysuckle and 15g of Forsythia, 3 doses, decocted in water, 1 dose per day, 2 times a day. After taking 1 dose of the medicine, the body temperature returned to normal, and the sore throat, itchy throat and cough were significantly relieved.

[0069] Case 4

[0070] Wang, female, 6 years old, was treated for "fever for 2 days". The patient had a sudden high fever 2 days ago, with an axillary temperature of 39.1°C. After taking ibuprofen suspension, the body temperature dropped, but the body temperature rose again on the second day, with an axillary temperature of 38.8°C, so she was treated in our hospital. The current symptoms are: fever, sore throat, occasional cough, red tongue with yellow greasy fur, and slippery pulse. The Chinese medicine antipyretic prescription of Example 3 of the present invention is given: 6g of Artemisia annua, 6g of Bupleurum, 3g of Notopterygium, 3g of Ephedra, 3g of Tsaoko, 9g of Radix Trichosanthis, 6g of Honeysuckle and 6g of Forsythia, 2 doses, decocted in water, 1 dose per day, 2 times a day. After taking the medicine once, the body temperature returned to normal, and there was no cough after taking 1 dose, and there was slight sore throat.

[0071] Case 5

[0072] Li, male, 4 years old, was treated for "fever for 1 day". The patient had a fever after catching a cold 1 day ago, with an axillary temperature of 38.5℃. After taking Xiaoer Chiqiao Qingre Granules, the body temperature did not drop significantly, so he was treated in our hospital. The current symptoms are: fever, occasional cough, red throat, red tongue with yellow fur, and slippery pulse. The Chinese medicine antipyretic prescription of Example 3 of the present invention, Artemisia annua 6g, Bupleurum 6g, Notopterygium 3g, Ephedra 3g, Tsaoko 3g, Radix Trichosanthis 9g, Flos Lonicerae 6g and Fructus Forsythiae 6g, 2 doses, decocted in water, 1 dose per day, 2 times a day. The body temperature returned to normal after taking the medicine once.

[0073] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not limitations on the implementation methods of the present invention. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made based on the above description. It is impossible to list all the implementation methods here. All obvious changes or modifications derived from the technical solution of the present invention are still within the protection scope of the present invention.

Claims

1. A Chinese medicinal composition for treating fever caused by viral infection, characterized in that: It is made of Artemisia annua 5-20g, Bupleurum 5-20g, Notopterygium wilfordii 3-10g, roasted Ephedra 3-10g, Tsaoko 3-10g, Radix Trichosanthis 10-30g, Flos Lonicerae 5-20g and Fructus Forsythiae 5-20g.

2. The antipyretic Chinese medicine composition according to claim 1, characterized in that: Based on weight parts, it is made from 20g of Artemisia annua, 20g of Bupleurum chinense, 10g of Notopterygium wilfordii, 10g of roasted Ephedra sinica, 10g of Tsaoko, 30g of Radix Trichosanthis, 20g of Flos Lonicerae and 20g of Fructus Forsythiae.

3. The antipyretic Chinese medicine composition according to claim 1, characterized in that: Based on weight parts, it is made from 15g of Artemisia annua, 15g of Bupleurum chinense, 9g of Notopterygium wilfordii, 9g of roasted Ephedra sinica, 6g of Amomum villosum, 30g of Radix Trichosanthis, 15g of Flos Lonicerae and 15g of Fructus Forsythiae.

4. The antipyretic Chinese medicine composition according to claim 1, characterized in that: Based on weight portions, it is made from 6g of Artemisia annua, 6g of Bupleurum chinense, 3g of Notopterygium wilfordii, 3g of roasted Ephedra sinica, 3g of Tsaoko, 9g of Radix Trichosanthis, 6g of Flos Lonicerae and 6g of Fructus Forsythiae.

5. The method for preparing the antipyretic Chinese medicinal composition for treating fever caused by viral infection according to any one of claims 1 to 4, characterized in that: The preparation method comprises: (1) Take Artemisia annua, Bupleurum chinense, Notopterygium wilfordii, roasted Ephedra sinica, Tsaoko, Radix Trichosanthis, Flos Lonicerae and Fructus Forsythiae according to the formula, add water and soak for 20-30 minutes; (2) Cook over low heat until boiling and continue cooking for 15-20 minutes; (3) Filter, add water to the residue and continue to boil for 15-20 minutes; (4) Repeat step (3) 1-2 times and combine the filtrates; or, (1) Powder Artemisia annua, Bupleurum chinense, Notopterygium wilfordii, roasted Ephedra sinica, Tsaoko, Radix Trichosanthis, Flos Lonicerae and Fructus Forsythiae according to the formula; (2) Mix the crushed APIs and extract with 70%-95% ethanol; (3) Filter, recover ethanol under reduced pressure, concentrate, and dry.

6. The preparation method according to claim 5, characterized in that: The preparation method further comprises the step of concentrating the filtrate obtained in step (4) into an extract.

7. The preparation method according to claim 6, characterized in that: The preparation method further comprises drying the extract into powder.

8. An antipyretic drug for treating fever caused by viral infection, characterized in that: The drug uses the antipyretic Chinese medicine composition described in any one of claims 1 to 4, or the antipyretic Chinese medicine composition prepared by the preparation method described in any one of claims 5 to 7 as an active ingredient.

9. The drug according to claim 8, characterized in that The drug also includes pharmaceutically acceptable excipients.

10. The drug according to claim 8, characterized in that The dosage form of the medicine is decoction, granules, pills, capsules, tablets, powders, ointments or oral liquids.

11. Use of the antipyretic Chinese medicinal composition according to any one of claims 1 to 4, or the antipyretic Chinese medicinal composition prepared by the preparation method according to any one of claims 5 to 7 in preparing a medicament for treating fever caused by viral infection.

12. The use according to claim 11, characterized in that: The fever caused by the viral infection is a fever caused by a lung viral infection or a fever caused by a new coronavirus infection.

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