Use of chlorindole hydrazide as a safener for herbicides

Abstract

The present application belongs to the technical field of herbicide safener, and particularly relates to the use of chlorindole hydrazide as a herbicide safener, chlorindole hydrazide as a safener of nicosulfuron, carfentrazone-ethyl, benzenesulfonamide and quizalofop-p-ethyl, which can relieve or eliminate the crop phytotoxicity caused by the above herbicides, and is applied after or before the crop phytotoxicity is caused. The application amount of chlorindole hydrazide (converted into the original drug) is 1-2 g / mu, the mass concentration of chlorindole hydrazide is 0.00667-0.01333% when applied, and a very good control effect can be achieved.

Description

Technical Field

[0001] This invention belongs to the field of herbicide safener technology, specifically relating to the use of chloroindolehydrazine as a herbicide safener. Background Technology

[0002] Nicosulfuron and quizalofop-P-ethyl are systemic herbicides that can be absorbed by the stems, leaves and roots of weeds and then translocated within the plant, causing sensitive plants to stop growing, turn pale, and gradually die. Herbicides such as oxychloride and flumetsulam are contact herbicides that cause leaf burn, but they can also have some adverse effects on crops. If crops show abnormal reactions due to pesticide application, affecting growth or reducing yield, it is called herbicide damage.

[0003] A safener, also known as a pesticide safener, is an organic compound used in combination with pesticides. It has no significant side effects on plants and can, to some extent, eliminate or alleviate pesticide damage; it is also called an antidote. Studies have shown that some synthetically produced plant hormone-like compounds (such as gibberellins) can be used as safeners. Pesticides, as exogenous compounds, can cause significant damage to crops when they affect the physiological metabolism of their target. When crops come into contact with these exogenous compounds, they activate the synthesis of related metabolic enzymes (such as cytochrome P450). Through a series of physiological and biochemical reactions, these enzymes remove as much pesticide as possible from the plant. The use of safeners can induce these enzymes to accelerate the metabolism of pesticides, ultimately achieving a detoxification effect.

[0004] Herbicide damage can cause significant crop yield losses. Although there are many safeners that can mitigate herbicide damage to crops to some extent, there are few safeners that are both effective and environmentally friendly and do not cause secondary damage. Summary of the Invention

[0005] To address the existing technical problems, this invention provides the use of chloroindolehydrazine as a safener to prevent herbicide damage to crops. Chloroindolehydrazine is harmless to crops, can prevent the side effects on crops caused by the use of various herbicides, and can increase crop yield, which is conducive to the promotion and application of chloroindolehydrazine in the field of plant pesticide safeners.

[0006] The technical solution of the present invention is as follows:

[0007] Uses of chloroindolehydrazine as a herbicide safener.

[0008] As one implementation method, the effective ingredient of the safener (chloroindolehydrazine) is used at a dosage of 1-2g / acre. Too much or too little will not achieve the best control effect within the above range.

[0009] As one implementation method, the mass concentration of chloroindolehydrazine during application is 0.00667-0.01333%.

[0010] As one implementation method: Chlorindolehydrazine can be applied together with or separately from the herbicide. The application rate is not affected by whether it is applied together or separately.

[0011] One implementation method involves applying chloroindolehydrazine together with a herbicide to crops during their seedling stage.

[0012] One implementation method is to apply chloroindolehydrazine to crops after they have suffered herbicide damage.

[0013] One method of application: application is by spraying.

[0014] One implementation method is as follows: the herbicide is one of nicosulfuron, oxychloride, flusulfanilamide, or quizalofop-P-ethyl.

[0015] One possible implementation method is to use one of the following crops: corn, wheat, mung beans, or soybeans.

[0016] In this invention, chloroindolehydrazine primarily affects the biological functions of plants, upregulating genes and mainly enriching metabolic, cellular, and single biological processes; as well as the catalytic activity and binding processes of molecular functions. Chloroindolehydrazine can eliminate or alleviate phytotoxicity caused by herbicide application to crops, effectively increasing crop yield.

[0017] The chloroindolehydrazine provided by this invention serves as a safener to eliminate or alleviate phytotoxicity caused by herbicide application to crops. As a safener, chloroindolehydrazine does not harm crops, can prevent side effects on crops caused by herbicide application, and can increase crop yield. This is conducive to the promotion and application of chloroindolehydrazine in the field of plant pesticide safeners. As a safener, chloroindolehydrazine is effective and environmentally friendly, and will not cause secondary phytotoxicity. Attached Figure Description

[0018] Figure 1 Symptoms of A-1 treated corn potted plants after spraying with nicosulfuron solution 6 days later;

[0019] Figure 2 Symptoms of corn potted plants treated with pesticide A-1 7 days after spraying with pesticide A;

[0020] Figure 3 Comparison of symptoms of A-1 treated corn plants sprayed with nicosulfuron solution 6 days after treatment with A-7 treated corn plants (water control).

[0021] Figure 4 Comparison of symptoms of corn potted plants treated with A-1 solution for 7 days with symptoms of A-7 solution treated with water.

[0022] Figures 3-4 In the diagram, the circled areas are for processing A-1, and the uncircled areas are for processing A-7. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions in the embodiments of this invention will be clearly and completely described below in conjunction with the embodiments of this invention. Obviously, the described embodiments are only some embodiments of this invention, not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0024] All materials used in the following examples were available through conventional channels. 10% chlorindolehydrazine SC, 40 g / L nicosulfuron SC, 10% cyclohexane WP, 25% flufenoxuron AS, and 10% quizalofop-P-ethyl EC were commercially available and kept for future use.

[0025] Example 1

[0026] The use of chloroindolehydrazine as a herbicide safener: The dosage of chloroindolehydrazine (converted to technical grade) is 1 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.00667%.

[0027] Preparation method of 0.00667% chloroindolehydrazine single-component solution: Add 10g of 10% chloroindolehydrazine SC to water to prepare 15L of solution A.

[0028] Example 2

[0029] The application of chloroindolehydrazine as a herbicide safener: The application rate of chloroindolehydrazine (converted to technical grade) is 2 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.01333%.

[0030] Preparation method of 0.01333% chloroindolehydrazine single-component solution: Add 20g of 10% chloroindolehydrazine SC to water to prepare 15L of solution B.

[0031] Example 3

[0032] The application of chloroindolehydrazine as a safener for herbicides: The application rate of chloroindolehydrazine (converted to technical grade) is 1 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.00667%.

[0033] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 10g of 10% chlorindolehydrazine SC and 120g of 40g / L nicosulfuron SC to water to prepare 15L solution C.

[0034] Example 4

[0035] The application of chloroindolehydrazine as a herbicide safener: The application rate of chloroindolehydrazine (converted to technical grade) is 2 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.01333%.

[0036] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 20g of 10% chlorindolehydrazine SC and 120g of 40g / L nicosulfuron SC to water to prepare 15L solution D.

[0037] Example 5

[0038] The application of chloroindolehydrazine as a safener for herbicides: The application rate of chloroindolehydrazine (converted to technical grade) is 1 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.00667%.

[0039] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 10g of 10% chlorindolehydrazine SC and 12g of 10% chlorpyrifos WP to water to prepare 15L solution E.

[0040] Example 6

[0041] The application of chloroindolehydrazine as a herbicide safener: The application rate of chloroindolehydrazine (converted to technical grade) is 2 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.01333%.

[0042] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 20g of 10% chlorindolehydrazine SC and 12g of 10% chlorpyrifos WP to water to prepare 15L solution F.

[0043] Example 7

[0044] The application of chloroindolehydrazine as a safener for herbicides: The application rate of chloroindolehydrazine (converted to technical grade) is 1 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.00667%.

[0045] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 10g of 10% chlorindolehydrazine SC and 30g of 25% flufenoxuron AS to water to prepare 15L solution G.

[0046] Example 8

[0047] The application of chloroindolehydrazine as a herbicide safener: The application rate of chloroindolehydrazine (converted to technical grade) is 2 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.01333%.

[0048] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 20g of 10% chlorindolehydrazine SC and 30g of 25% flufenoxuron AS to water to prepare 15L of solution H.

[0049] Example 9

[0050] The application of chloroindolehydrazine as a safener for herbicides: The application rate of chloroindolehydrazine (converted to technical grade) is 1 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.00667%.

[0051] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 10g of 10% chlorindolehydrazine SC and 20g of 10% quizalofop-P-ethyl EC to water to prepare 15L solution I.

[0052] Example 10

[0053] The application of chloroindolehydrazine as a herbicide safener: The application rate of chloroindolehydrazine (converted to technical grade) is 2 g / mu, and the mass concentration of chloroindolehydrazine at the time of application is 0.01333%.

[0054] Preparation method of two-component solution of chlorindolehydrazine and herbicide: Add 20g of 10% chlorindolehydrazine SC and 20g of 10% quizalofop-P-ethyl EC to water to prepare 15L solution J.

[0055] The specific preparation method of the above-mentioned drug solution is as follows: First, weigh the safety agent chloroindolehydrazine and the purchased drug into the sample bottle according to the prescribed dosage. Then, dilute them twice and pour them into an electric sprayer containing a small amount of water. Finally, bring the water in the electric sprayer to a final volume of 15L to prepare the required drug solution.

[0056] Experimental example:

[0057] Preparation method of nicosulfuron single-component solution: 120g of 40g / L nicosulfuron SC agent is diluted with water to prepare 15L of solution.

[0058] Preparation method of cyclohexane single-component solution: 12g of 10% cyclohexane WP is diluted with water to prepare 15L of solution;

[0059] Preparation method of flumetsulam single-component solution: 30g of 25% flumetsulam AS is diluted with water to prepare 15L of solution;

[0060] Preparation method of single-component quizalofop-P-ethyl solution: 20g of 10% quizalofop-P-ethyl EC is diluted with water to prepare 15L of solution;

[0061] In the following test examples, the amount of pesticide solution and water sprayed was 15L per acre, which was the standard dosage. The standard was that the solution was sprayed evenly on the leaf surface and the solution did not drip.

[0062] Experimental Example 1

[0063] On March 2, 2022, potted maize seedlings with 3-6 leaves and similar growth at the greenhouse stage were selected and divided into 8 treatments: A-1, A-2, A-3, A-4, A-5, A-6, A-7, and A-8, with each group consisting of 2 treatments. Treatments A-1, A-2, A-3, and A-4 were sprayed with a single-component nicosulfuron solution; A-5 was sprayed with solution C, and A-6 with solution D; A-7 and A-8 were sprayed with water as a control. Six days later, the maize seedlings in treatments A-1, A-2, A-3, and A-4 showed phytotoxicity, with symptoms including yellowing of the central leaves, growth inhibition, and some seedlings exhibiting twisted hearts. The phytotoxicity observed in treatment A-1 is described in [details omitted]. Figure 1 As shown, yellowing of the central leaves was obvious; the corn seedlings in treatments A-5 and A-6 grew normally, with fewer plants showing pesticide damage; the corn seedlings in treatments A-7 and A-8 grew normally, with no pesticide damage; the growth of A-1 and A-7 seedlings was compared after 6 days. Figure 3 As shown, A-1 treatment inhibits growth;

[0064] Corn seedlings in treatments A-1 were sprayed with pesticide solution A, and those in treatments A-2 were sprayed with pesticide solution B. Seedlings in treatments A-3 and A-4 that experienced pesticide damage were sprayed with water. Seedlings in treatments A-5, A-6, A-7, and A-8 were not sprayed with pesticide solution or water. After 7 days, the growth of seedlings in treatments A-1 and A-2 gradually recovered, the yellowing lessened, the leaves turned green, and the seedlings gradually returned to normal. The recovery of treatment A-1 was observed... Figure 2 As shown, the yellowing of new leaves recovered; the pesticide damage symptoms in treatments A-3 and A-4 remained unchanged; treatments A-5, A-6, A-7, and A-8 showed normal overall growth; and the growth comparison between treatments A-1 and A-7 after 7 days is shown in the figure. Figure 4 As shown, the growth inhibition caused by A-1 treatment was basically restored;

[0065] Observe the herbicide damage, calculate the herbicide damage rate, and record the recovery of corn after applying chlorindolehydrazine and water following herbicide damage to nicosulfuron. The records are shown in Table 1 below:

[0066]

[0067]

[0068] In the above experimental examples, chlorindolehydrazine was applied after the herbicide caused phytotoxicity, which greatly reduced the phytotoxicity response of corn to nicosulfuron. The results showed that applying chlorindolehydrazine after corn was damaged by nicosulfuron allowed the corn to recover to its normal physiological state. The combined application of chlorindolehydrazine and nicosulfuron reduced the occurrence of phytotoxicity.

[0069] Experimental Example 2

[0070] On March 2, 2022, potted wheat seedlings with uniform growth in a greenhouse were selected and divided into six treatments: B-1, B-2, B-3, B-4, B-5, and B-6, with each group consisting of two treatments. Treatments B-1, B-2, B-3, and B-4 were sprayed with a single-component solution of cyclohexane; treatment B-5 was sprayed with solution E, and treatment B-6 was sprayed with solution F; treatments B-7 and B-8 were sprayed with water as a control. Eight days later, wheat seedlings in treatments B-1, B-2, B-3, and B-4 showed phytotoxicity, with symptoms including leaf burning. Wheat seedlings in treatments B-5 and B-6 grew normally, with fewer seedlings showing phytotoxicity. Wheat seedlings in treatments B-7 and B-8 grew normally and did not show phytotoxicity.

[0071] Wheat seedlings with herbicide damage in treatment B-1 were sprayed with pesticide solution A, and wheat seedlings with herbicide damage in treatment B-2 were sprayed with pesticide solution B. Wheat seedlings with herbicide damage in treatments B-3 and B-4 were sprayed with water, while wheat seedlings with herbicide damage in treatments B-5, B-6, B-7, and B-8 were not sprayed with pesticide solution or water. After 7 days, the leaves of treatments B-1 and B-2 gradually recovered and turned green; the herbicide damage symptoms of treatments B-3 and B-4 remained unchanged; and the overall growth of treatments B-5, B-6, B-7, and B-8 was normal.

[0072] Observe the herbicide damage, calculate the herbicide damage rate, and record the recovery of wheat after applying chlorindolehydrazine and water following herbicide damage to parabens. The records are shown in Table 2 below.

[0073]

[0074]

[0075] In the above experimental examples, applying chlorindolehydrazine after herbicide damage occurred can greatly reduce the wheat's response to herbicide-induced damage. The results show that applying chlorindolehydrazine after wheat has been damaged by herbicide-induced damage can help wheat recover to its normal physiological state. The combined application of chlorindolehydrazine and herbicide-induced damage can effectively reduce the occurrence of herbicide damage.

[0076] Experimental Example 3

[0077] On March 8, 2022, potted soybean seedlings with uniform growth in a greenhouse were selected and divided into six treatments: C-1, C-2, C-3, C-4, C-5, and C-6, with each group consisting of two treatments. Treatments C-1, C-2, C-3, and C-4 were sprayed with a single-component solution of flufenoxuron; C-5 was sprayed with solution G, and C-6 was sprayed with solution H; C-7 and C-8 were sprayed with water as a control. Seven days later, soybean seedlings in treatments C-1, C-2, C-3, and C-4 showed phytotoxicity, with symptoms including inhibited plant growth and leaf scorching. Wheat seedlings in treatments C-5 and C-6 grew normally, with fewer seedlings showing phytotoxicity. Wheat seedlings in treatments C-7 and C-8 grew normally and did not show phytotoxicity.

[0078] Soybean seedlings with pesticide damage in treatment C-1 were sprayed with pesticide solution A; soybean seedlings with pesticide damage in treatment C-2 were sprayed with pesticide solution B; soybean seedlings with pesticide damage in treatments C-5, C-6, C-7, and C-8 were not sprayed with pesticide solution or water; soybean seedlings with pesticide damage in treatments C-3 and C-4 were sprayed with water; after 7 days, the plant height and leaf color of treatments C-1 and C-2 gradually recovered; the pesticide damage symptoms of treatments C-3 and C-4 remained unchanged; and the overall growth of treatments C-5, C-6, C-7, and C-8 was normal.

[0079] Observe the herbicide damage, calculate the herbicide damage rate, and record the recovery of soybeans after application of chlordane and water following herbicide damage to flumetsulam. The records are shown in Table 3 below.

[0080]

[0081]

[0082] In the above experimental examples, chlorindolehydrazine was applied after the herbicide caused phytotoxicity, which greatly reduced the phytotoxicity response of soybeans to flusulfanilamide. The results showed that after soybeans were phytotoxicated by flusulfanilamide, the application of 10% chlorindolehydrazine allowed the soybeans to recover to a normal physiological state. The combined application of chlorindolehydrazine and flusulfanilamide was beneficial in reducing the occurrence of phytotoxicity.

[0083] Test Example 4

[0084] On March 12, 2022, potted soybean seedlings with uniform growth in a greenhouse were selected and divided into six treatments: D-1, D-2, D-3, D-4, D-5, and D-6, with each group consisting of two treatments. Treatments D-1, D-2, D-3, and D-4 were sprayed with a single-component solution of quizalofop-P-ethyl; D-5 was sprayed with solution I, and D-6 with solution J; treatments D-7 and D-8 were sprayed with water as a control. Seven days later, the soybean seedlings in treatments D-1, D-2, D-3, and D-4 showed phytotoxicity, with symptoms including inhibited growth and chlorosis. The seedlings in treatments D-5 and D-6 showed generally normal growth with fewer seedlings showing phytotoxicity. The seedlings in treatments D-7 and D-8 showed normal growth without phytotoxicity.

[0085] Mung bean seedlings with pesticide damage in treatment D-1 were sprayed with pesticide solution A, and mung bean seedlings with pesticide damage in treatment D-1 were sprayed with pesticide solution B; mung bean seedlings with pesticide damage in treatments D-3 and D-4 were sprayed with water, and mung bean seedlings with pesticide damage in treatments D-5, D-6, D-7, and D-8 were not sprayed with pesticide solution or water; after 7 days, the leaf height and leaf color of treatments D-1 and D-2 gradually recovered; the pesticide damage symptoms of treatments D-3 and D-4 remained unchanged; and the overall growth of treatments D-5, D-6, D-7, and D-8 was normal.

[0086] Observe the damage caused by phytotoxicity, calculate the damage rate, and record the recovery of mung beans after applying chlordane and water following phytotoxicity to mung beans. The records are shown in Table 4 below.

[0087]

[0088]

[0089] In the above experimental examples, applying chlordane after the herbicide caused phytotoxicity can greatly reduce the phytotoxicity response of mung beans to quizalofop-P-ethyl. The results show that applying chlordane after mung beans have been damaged by quizalofop-P-ethyl allows them to recover to their normal physiological state. The combined application of chlordane and quizalofop-P-ethyl effectively reduces the occurrence of phytotoxicity.

[0090] The present invention provides the use of chloroindolehydrazine as a safener to prevent herbicide damage to crops. Chloroindolehydrazine, as a safener, does not harm crops, can prevent the side effects on crops caused by herbicide use, and can increase crop yield. It is conducive to the promotion and application of chloroindolehydrazine in the field of plant pesticide safeners. As a safener, chloroindolehydrazine is effective and environmentally friendly, and will not cause secondary phytotoxicity.

Claims

1. The use of chloroindolehydrazine as a herbicide safener, characterized in that, The safener's effective ingredient dosage is 1-2 g / mu, and the herbicide is one of nicosulfuron, oxychloride, flusulfanilamide, and quizalofop-P-ethyl.

2. The use according to claim 1, characterized in that, When applied, the mass concentration of chloroindolehydrazine is 0.00667-0.01333%.

3. The use according to claim 1, characterized in that, The chloroindolehydrazine can be applied together with or separately from the herbicide.

4. The use according to claim 3, characterized in that, The chloroindolehydrazine is applied in combination with the herbicide to crops during their growing season.

5. The use according to claim 4, characterized in that, The growth period mentioned refers to the seedling stage.

6. The use according to claim 3, characterized in that, After crops suffer from herbicide damage, chloroindolehydrazine is applied to the crops.

7. The use according to claim 4, characterized in that, The application is by spraying.

8. The use according to claim 4 or 6, characterized in that, The crop mentioned is one of corn, wheat, mung beans, or soybeans.

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