A foam disinfectant containing glutaraldehyde-decylamine bromide and its preparation method

Abstract

This invention discloses a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant and its preparation method, belonging to the technical field of livestock and poultry disinfectants. It is made from the following raw materials in the indicated mass percentages: glutaraldehyde 3%-10%, decylmethylammonium bromide 3%-10%, foaming agent 1%-5%, control stabilizer 0.5%-3%, with the balance being deionized water; the control stabilizer comprises a composition formed by nanomaterials, organosiloxanes, and solvents. By adding a certain amount of control stabilizer and a specific foaming agent, this invention avoids the influence of conventional foaming agents on the identification of the glutaraldehyde-decylmethylammonium bromide system, without affecting the solution stability and usability, maintaining long-lasting foam adhesion, and providing good cleaning and disinfection effects.

Description

Technical Field

[0001] This invention relates to the field of livestock and poultry disinfectant technology, specifically to a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant and its preparation method. Background Technology

[0002] African swine fever (ASF) is a highly contagious disease caused by the African swine fever virus (ASFV), with a mortality rate that can reach 100%, seriously affecting the healthy development of my country's pig industry. The disease can spread among pigs through direct contact, indirect contact, and short-range aerosol transmission, and can also circulate among domestic pigs, wild boars, soft ticks, and back to domestic pigs. Currently, there is no commercially available vaccine for ASFV. Quarantine, culling, and appropriate biosecurity measures are the main means of controlling the disease, with disinfection being of paramount importance in the breeding process. Contact with contaminated pens is a significant route of infection for livestock and poultry; therefore, thorough cleaning and disinfection of pens are crucial for disease prevention and hygiene.

[0003] Glutaraldehyde is an aldehyde disinfectant that can kill vegetative bacteria and spores, fungi, viruses, etc. The killing effect of aldehyde disinfectants on microorganisms mainly relies on the aldehyde group. The aldehyde group acts on the sulfhydryl, hydroxyl, carboxyl, and amino groups of bacterial proteins, causing alkylation and protein coagulation, leading to bacterial death. Decyl bromide is a double long-chain cationic surfactant. Its quaternary ammonium cations can actively attract and accumulate on the surface of negatively charged bacteria and viruses, hindering bacterial metabolism and altering their membrane permeability. Combining glutaraldehyde with dedecyl bromide makes it easier for glutaraldehyde to penetrate the interior of bacteria and viruses, destroying protein and enzyme activity, achieving rapid and efficient disinfection. However, in the glutaraldehyde-decyl bromide system, dedecyl bromide acts as both a bactericide and a foaming agent, thus also serving as a foam cleaning agent. However, the foam in this system is unstable, has poor adhesion to surfaces, and the foam's adhesion time is short, generally 1-3 minutes, resulting in high water consumption and poor disinfection and cleaning effects. When using glutaraldehyde-decylamine bromide solution products on the market, the premises are usually cleaned first, and then disinfected. This requires a large amount of water for rinsing, which wastes water resources.

[0004] To improve foam performance, existing glutaraldehyde-decylmethyl bromide systems typically incorporate surfactants as foam stabilizers or additives. These surfactants can be nonionic, amphoteric, anionic, or fatty alcohols, or a combination thereof. Nonionic surfactants are generally alkyl glucosides and fatty alcohol polyoxyethylene ethers; however, their addition to the glutaraldehyde-decylmethyl bromide (or benzalkonium chloride) system affects the identification of bromide (or chloride) ions, leading to a lower product qualification rate. Amphoteric surfactants are commonly alkyl betaines, but overall foam performance remains unstable, with poor foam adhesion (typically 1-3 minutes). Anionic surfactants are typically alkyl sulfates, alkyl sulfonates, alkyl alcohol ether sulfates, and alkyl alcohol ether sulfonates; however, anionic surfactants readily react with decylmethyl bromide in the glutaraldehyde-decylmethyl bromide system, reducing its content and affecting bactericidal performance. Another type of surfactant added is the fluorocarbon surfactant. Fluorocarbon surfactants can improve foam performance, and while they may improve foam quality significantly, they are difficult to degrade and have certain biological effects. Even with conventional mixtures of several surfactants, the impact on the identification of the glutaraldehyde-decylmethyl bromide system and the content of decylmethyl bromide remains unresolved.

[0005] For example, CN114342928A discloses a foam generator for disinfectants and a method for preparing foam-type veterinary disinfectants. The foam generator is composed of fatty alcohol polyoxyethylene ether, PEG400, and fluorocarbon surfactants. Fluorocarbon surfactants (especially long-chain fluorocarbon surfactants PFOS and PFOA) have weak biodegradability in the environment and have been banned in many fields. Publication No. CN113197202A discloses a composite glutaraldehyde foam disinfectant and its preparation method. The method uses glutaraldehyde-double-chain quaternary ammonium salt (decyl bromide) and mixes several substances such as alkyl glucoside, fatty alcohol polyether, and alkyl betaine according to the specified ratio. However, this mixture still cannot solve the identification problem of the glutaraldehyde-decyl bromide system. In addition, the pH value of the solution is 5-9 (preferably 6-9, specifically 6.5-8.5). At this pH value, the activity of the glutaraldehyde solution is relatively the best, but the stability is relatively poor. At 4°C, it can only be maintained for 14 days in alkaline aqueous solution (pH value of 7.5-8.5), so the storage performance is poor and it is more prone to failure.

[0006] In summary, the surfactants or foam stabilizers added to the glutaraldehyde-decylmethylammonium bromide system have problems such as affecting system identification, poor foam adhesion, poor biodegradability, and unstable solution content. Therefore, there is a need for a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant that does not affect the identification of the glutaraldehyde-decylmethylammonium bromide solution, is stable in solution and foam, and is safe and environmentally friendly. Summary of the Invention

[0007] To address the aforementioned issues, this invention provides a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant and its preparation method. By adding a certain amount of control stabilizer and a specific foaming agent, the influence of conventional foaming agents on the identification of the glutaraldehyde-decylmethylammonium bromide system can be avoided, without affecting the stability and usability of the solution, maintaining long-lasting foam adhesion to the wall, and providing good cleaning and disinfection effects.

[0008] To achieve the above objectives, the present invention is implemented through the following technical solution:

[0009] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 3%-10%, decylmethylammonium bromide 3%-10%, foaming agent 1%-5%, control stabilizer 0.5%-3%, and the balance being deionized water;

[0010] The control stabilizer comprises a composition formed of nanomaterials, organosiloxanes, and solvents, wherein the control stabilizer is in the following mass percentages: 0.1%-5% nanomaterials, 40%-60% organosiloxanes, and the balance being solvent.

[0011] Furthermore, the nanomaterial is one or more of silicon dioxide, titanium dioxide, and halloysite.

[0012] Furthermore, the organosiloxane is one or more of the following: polyether-modified amino silicone oil, polyether-epoxy modified organosiloxane, epoxy-modified polymethylsiloxane, and polysiloxane-polyether copolymer.

[0013] Furthermore, the solvent includes one or more of propylene glycol methyl ether, propylene glycol ethyl ether, propylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol methyl ether, diethylene glycol ethyl ether, diethylene glycol propyl ether, dipropylene glycol butyl ether, diethylene glycol butyl ether, glycerol butyl ether, diethylene glycol, butanol, triethylene glycol, and water.

[0014] Furthermore, the foaming agent includes one or more of zwitterionic surfactants and nonionic surfactants.

[0015] Furthermore, the nonionic surfactant includes any one or more of alkyl glucose, fatty alcohol polyoxyethylene ether, fatty acid alcohol ester, and fatty acid alcohol ester polyoxyethylene ether.

[0016] Furthermore, the zwitterionic surfactant includes one or more of fatty alkyl amine oxides and alkyl methyl betaine.

[0017] Furthermore, the aliphatic alkyl amine oxide is any one or more of alkyl amine oxides with a carbon chain length of C8-C18.

[0018] Furthermore, the fatty alkyl amine oxide is a mixture of C12 alkyl amine oxide and C16 alkyl amine oxide in a mass ratio of 9:1 to 1:9.

[0019] Furthermore, the fatty acid alcohol ester polyoxyethylene ether includes any one or more of the following: polyoxyethylene ether oleate mixture, polyoxyethylene (20) sorbitan monolaurate (T-20), polyoxyethylene sorbitan monopalmitate (T-40), sorbitan monostearate polyoxyethylene (20) ether (T-60), polyoxyethylene dehydrated sorbitan monooleate (T-80), and polyoxyethylene sorbitan trioleate (T-85).

[0020] This invention also claims a method for preparing a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant, comprising the following steps:

[0021] (1) First, mix glutaraldehyde and decyl bromide solution evenly, then add control stabilizer and continue stirring evenly, then add deionized water and stir evenly to obtain premixed solution A;

[0022] (2) Continue stirring and mixing the premixed solution A with the foaming agent until the solution presents a homogeneous and transparent mixture B;

[0023] (3) Add pH adjuster as needed to adjust the pH of mixture B to 3.0-6.0 to obtain the finished product glutaraldehyde decyl bromide solution foam disinfectant.

[0024] Furthermore, the pH adjuster mentioned in step (3) is either citric acid or phosphoric acid.

[0025] This invention discloses a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant and its preparation method, the beneficial effects of which are:

[0026] (1) According to national standards, 10% dilute nitric acid needs to be added to the glutaraldehyde-decylmethylammonium bromide solution for identification, mainly to identify the generated decylmethylammonium salt. However, commonly used hydrocarbon surfactants tend to enlarge the micelles in the solution, increasing the solubility of decylmethylammonium salt and affecting the product qualification rate identification. This invention incorporates a control stabilizer and a foaming agent to change the distribution of decylmethylammonium bromide micelle concentration in the glutaraldehyde-decylmethylammonium bromide solution, keeping the decylmethylammonium bromide micelle concentration unchanged or decreasing. This does not affect the solubility of the decylmethylammonium salt generated by silver nitrate and decylmethylammonium bromide during the identification process, thus improving the influence of surfactants on the identification of decylmethylammonium salt, ensuring the identification of qualified products, and reducing losses.

[0027] (2) In this invention, a foaming agent is added to the glutaraldehyde-quaternary ammonium salt system, which improves the stability of the foam liquid film in the glutaraldehyde-quaternary ammonium salt system. The organosilicon polysiloxane in the added control stabilizer can further reduce the surface tension, increase the stability of the foam and the adhesion of the solid surface, thereby prolonging the wall adhesion performance, while increasing the wetting, emulsifying and bactericidal properties of the system.

[0028] (3) The addition of nanomaterials forms weak bonds with surfactant molecules in the foaming agent, causing significant changes in its rheology and producing an effective synergistic effect to increase foam stability. Because nanoparticles have a large surface area and high free energy, surfactants easily adsorb onto their surface, resulting in stronger adsorption of nanoparticles onto the foam surface, preventing bubble aggregation, inhibiting liquid film drainage, and improving the mechanical strength of the liquid film. It also increases the adhesion or viscous friction between the foam and the solid surface, further extending the wall-hanging performance, thereby prolonging the time the foam adheres to the solid surface, increasing the contact time for disinfecting and cleaning object surfaces, and extending the interaction time between the solution and pathogens and dirt, especially for complex object surfaces with grooves, mesh, or a fence-like structure.

[0029] (4) This invention uses a combination of nanomaterials and organosiloxanes. By grafting and modifying the nanomaterials with organosilicone, the dispersibility and stability of the nanoparticles can be effectively improved, forming a transparent and uniform control stabilizer. In addition, based on the property of nanomaterials agglomerating at the gas-liquid interface, it can inhibit the aggregation and disproportionation between bubbles, control the drainage time of the liquid film, and improve foam stability. Organosiloxanes have high chemical stability, good heat resistance and cold resistance, and can remain stable over a wide temperature range. Furthermore, the main chain of organosilicone surfactants is a soft Si-O bond, and the side chains are methyl groups arranged at the interface, which reduces the surface tension to about 20 mN / m, while ordinary hydrocarbon surfactants, with methylene groups arranged at the interface, can only reduce the surface tension to about 30 mN / m. Therefore, its addition can reduce the surface tension of the system and improve the wetting and permeability of the system solution. In addition, organosiloxanes can be rapidly degraded and are biologically and environmentally friendly. Furthermore, it can assist surfactants in improving the foam stability of the glutaraldehyde-decylmethylammonium bromide system. After foam stabilization, the disinfection and cleaning effects are better, allowing for cleaning with lower water volumes and further saving rinsing water. The combination of organosiloxanes and nanomaterials can effectively improve the dispersibility of nanoparticles, preventing aggregation and affecting the appearance and storage properties of the solution. It can also regulate the flow rate of water molecules on the foam film, giving the foam good self-healing capabilities and reducing bleeding. The combination of stabilizers and foaming agents can effectively reduce the charge repulsion between the foam bilayer, thereby enhancing foam stability.

[0030] (5) The surfactants added in this invention are preferably short-chain nonionic surfactants and amphoteric surfactants, which are not prone to react with glutaraldehyde and cationic decanmethyl bromide and do not affect product identification, thereby maintaining the content of effective components in the glutaraldehyde-decanmethyl bromide system, that is, maintaining solution stability. Attached Figure Description

[0031] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0032] Figure 1 The blank sample shows the cleaning and decontamination effect on the cement walls of a pigsty in a farm.

[0033] Figure 2 The foam disinfectant in Example 1 demonstrates its effectiveness in cleaning and removing dirt from the cement walls of a pigsty in a livestock farm.

[0034] Figure 3 The foam disinfectant in Example 6 is shown to be effective in cleaning and removing dirt from the cement walls of a pigsty in a farm.

[0035] Figure 4 The foam disinfectant in Example 9 is shown to be effective in cleaning and removing dirt from the cement walls of a pigsty in a farm.

[0036] Figure 5 The foam disinfectant in Example 13 demonstrates its effectiveness in cleaning and removing dirt from the cement walls of pigsties in a livestock farm. Detailed Implementation

[0037] To enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be clearly and completely described below with reference to embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] Glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in weight percentage: glutaraldehyde 3-10%, decylmethylammonium bromide 3-10%, foaming agent 1-5%, control stabilizer 0.5-3%, and the balance being deionized water.

[0039] As a preferred embodiment, the mass ratio of glutaraldehyde to decyl bromide is 1:1.

[0040] As one implementation method, the foaming agent is any one or more of nonionic surfactants and amphoteric surfactants.

[0041] In another embodiment, the zwitterionic surfactant includes one or more of fatty alkyl amine oxides and alkyl methyl betaine.

[0042] As another embodiment, the fatty alkyl amine oxide is any one or more of the alkyl amine oxides with a carbon chain length of C8-C18.

[0043] In another embodiment, the fatty alkyl amine oxide is a mixture of C12 alkyl amine oxide and C16 alkyl amine oxide in a mass ratio of 9:1 to 1:9.

[0044] As another embodiment, the nonionic surfactant is any one or more of alkyl glucosides, fatty alcohol polyoxyethylene ethers, fatty acid alcohol esters, and fatty acid alcohol ester polyoxyethylene ethers.

[0045] In another embodiment, the alkyl glucoside includes any one or a mixture of C6-C16 alkyl glycosides. Preferably, it includes one or more of C6-C10 alkyl glycosides.

[0046] As another implementation method, the chemical formula of fatty alcohol polyoxyethylene ether is RO(CH2CH2O). n H, where n is 2-20, preferably 5-15.

[0047] In another embodiment, the fatty acid alcohol ester polyoxyethylene ether comprises any one or more of the following: a mixture of polyoxyethylene ether oleate, polyoxyethylene (20) sorbitan monolaurate (T-20), polyoxyethylene sorbitan monopalmitate (T-40), sorbitan monostearate polyoxyethylene (20) ether (T-60), polyoxyethylene dehydrated sorbitan monooleate (T-80), and polyoxyethylene sorbitan trioleate (T-85). Preferably, one or more of T-20, T-60, T-80, and T-85 are used.

[0048] In one embodiment, the control stabilizer is a solution prepared from nanomaterials, solvents, and organosiloxanes in a certain proportion.

[0049] In another embodiment, the control stabilizer is a composition formed of nanomaterials, organosiloxanes and solvents, wherein the control stabilizer is in the following mass percentages: 0.1%-5% nanomaterials, 40%-60% organosiloxanes, and the balance being solvent.

[0050] As another implementation method, the nanomaterial is nano-silica.

[0051] As another implementation method, the organosiloxane is one or more of polyether-modified amino silicone oil, polyether-epoxy-modified silicone oil, epoxy-modified polymethylsiloxane, and polysiloxane-polyether copolymer.

[0052] In another embodiment, the solvent includes a mixture of a solubilizer and water, wherein the solubilizer is one or more of propylene glycol methyl ether, propylene glycol ethyl ether, propylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol methyl ether, diethylene glycol ethyl ether, diethylene glycol propyl ether, dipropylene glycol butyl ether, diethylene glycol butyl ether, glycerol butyl ether, diethylene glycol, butanol, and triethylene glycol.

[0053] As a preferred method, the solvent is obtained by mixing a solubilizer and water at a mass ratio of 1:1-10.

[0054] Method Example 1

[0055] A method for preparing a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant includes the following steps:

[0056] (1) First, mix glutaraldehyde and decyl bromide solution evenly, then add control stabilizer and continue stirring evenly, then add deionized water and stir evenly to obtain premixed solution A;

[0057] (2) Continue stirring and mixing the premixed solution A with the foaming agent until the solution presents a homogeneous and transparent mixture B;

[0058] (3) Add phosphoric acid as a pH adjuster as needed to adjust the pH of mixture B to 3.0, and the finished product glutaraldehyde decyl bromide solution foam disinfectant is obtained.

[0059] Method Example 2

[0060] A method for preparing a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant includes the following steps:

[0061] (1) First, mix glutaraldehyde and decyl bromide solution evenly, then add control stabilizer and continue stirring evenly, then add deionized water and stir evenly to obtain premixed solution A;

[0062] (2) Continue stirring and mixing the premixed solution A with the foaming agent until the solution presents a homogeneous and transparent mixture B;

[0063] (3) Add citric acid as a pH adjuster as needed to adjust the pH of mixture B to 6.0, and the finished product glutaraldehyde decyl bromide solution foam disinfectant is obtained.

[0064] Method Example 3

[0065] A method for preparing a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant includes the following steps:

[0066] (1) First, mix glutaraldehyde and decyl bromide solution evenly, then add control stabilizer and continue stirring evenly, then add deionized water and stir evenly to obtain premixed solution A;

[0067] (2) Continue stirring and mixing the premixed solution A with the foaming agent until the solution presents a homogeneous and transparent mixture B;

[0068] (3) Add citric acid as a pH adjuster as needed to adjust the pH of mixture B to 4.0, and the finished product glutaraldehyde decyl bromide solution foam disinfectant is obtained.

[0069] Example 1

[0070] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated mass percentages: glutaraldehyde 3%, decylmethylammonium bromide 3%, foaming agent 1%, control stabilizer 0.5%, and the balance being deionized water;

[0071] In this embodiment, the foaming agent is hexylalkyl glycoside and dodecyl dimethyl betaine in a mass ratio of 1:1.

[0072] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 5% nano-silica, 40% polyether epoxy modified silicone oil, and the remainder is solvent, which is a mixture of propylene glycol methyl ether and water in a ratio of 1:10.

[0073] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0074] Example 2

[0075] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 3%, control stabilizer 2%, and the balance being deionized water;

[0076] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 3% nano-silica, 50% polyether epoxy modified silicone oil, and the remainder is a mixture of solvent propylene glycol ethyl ether and water in a 1:5 ratio.

[0077] In this embodiment, the foaming agent is hexylalkyl glycoside and dodecyl dimethyl betaine in a mass ratio of 1:2.

[0078] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0079] Example 3

[0080] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 1%, and the balance being deionized water;

[0081] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 1% nano-silica, 55% polyether epoxy modified silicone oil, and the remaining solvent is a mixture of diethylene glycol ethyl ether and water in a 1:1 ratio.

[0082] In this embodiment, the foaming agent is hexylalkyl glycoside and dodecyl dimethyl betaine in a mass ratio of 2:1.

[0083] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 2.

[0084] Example 4

[0085] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 0.5%, and the balance being deionized water;

[0086] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 3% nano-silica, 50% polyether epoxy modified silicone oil, and the remaining solvent is a mixture of triethylene glycol and water in a 1:5 ratio.

[0087] In this embodiment, the foaming agent is a mixture of hexylalkyl glycoside, dodecylamine oxide, and hexadecylamine oxide in a mass ratio of 4:1:1.

[0088] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0089] Example 5

[0090] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 2%, and the balance being deionized water;

[0091] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 3% nano-silica, 50% polyether-modified amino silicone oil, and the remaining solvent is a mixture of diethylene glycol and water in a 1:5 ratio.

[0092] In this embodiment, the foaming agent is a mixture of ethylalkyl glycoside, dodecylamine oxide, and hexadecylamine oxide in a mass ratio of 6:2:1.

[0093] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0094] Example 6

[0095] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 2%, and the balance being deionized water;

[0096] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 3% nano-silica, 50% polysiloxane-polyether copolymer, and the remaining solvent is butanol and water mixed in a 1:5 ratio.

[0097] In this embodiment, the foaming agent is a mixture of ethyl alkyl glycoside and fatty alcohol polyoxyethylene ether-5 in a mass ratio of 2:1.

[0098] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0099] Example 7

[0100] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: 10% glutaraldehyde, 10% decylmethylammonium bromide, 5% foaming agent, 2% control stabilizer, and the balance being deionized water.

[0101] In this embodiment, the stabilizer is controlled by the following composition based on a mass fraction of 100%: 3% nano-silica, 50% epoxy-modified polymethylsiloxane, and the remaining solvent is a mixture of triethylene glycol and water in a 1:5 ratio.

[0102] In this embodiment, the foaming agent is a mixture of dodecyl dimethyl betaine and fatty alcohol polyoxyethylene ether-5 in a mass ratio of 1:1.

[0103] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0104] Example 8

[0105] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 7%, decylmethylammonium bromide 7%, foaming agent 5%, control stabilizer 2%, and the balance being deionized water;

[0106] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 3% nano silica, 40% polyether epoxy modified silicone oil, 10% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0107] In this embodiment, the foaming agent is a mixture of dodecyl dimethyl betaine and fatty alcohol polyoxyethylene ether-7 in a mass ratio of 1:1.

[0108] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0109] Example 9

[0110] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: 10% glutaraldehyde, 10% decylmethylammonium bromide, 5% foaming agent, 2% control stabilizer, and the balance being deionized water.

[0111] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 3% nano silica, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0112] In this embodiment, the foaming agent is a mixture of decyl alkyl glycoside, Tween 80, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:1:0.9:0.1:1.

[0113] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0114] Example 10

[0115] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: 10% glutaraldehyde, 10% decylmethylammonium bromide, 5% foaming agent, 2% control stabilizer, and the balance being deionized water.

[0116] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 3% nano titanium dioxide, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is a mixture of triethylene glycol and water in a 1:5 ratio.

[0117] In this embodiment, the foaming agent is a mixture of decylalkyl glycoside, Tween 60, dodecyl dimethyl betaine and fatty alcohol polyoxyethylene ether-15 in a mass ratio of 2:1:1:1.

[0118] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0119] Example 11

[0120] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: 10% glutaraldehyde, 10% decylmethylammonium bromide, 5% foaming agent, 2% control stabilizer, and the balance being deionized water.

[0121] In this embodiment, the stabilizer, calculated by mass fraction of 100%, is as follows: 1% nano halloysite, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0122] In this embodiment, the foaming agent is a mixture of octyldecyl alkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 1:0.2:1.8:1:1;

[0123] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0124] Example 12

[0125] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 2%, and the balance being deionized water;

[0126] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 2% nano silica, 1% nano titanium dioxide, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0127] In this embodiment, the foaming agent is a mixture of octyldecyl alkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0128] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0129] Example 13

[0130] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 2%, and the balance being deionized water;

[0131] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 2% nano silica, 1% nano titanium dioxide, 0.5% nano tallosite, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0132] In this embodiment, the foaming agent is a mixture of hexylalkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0133] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0134] Example 14

[0135] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, control stabilizer 1%, and the balance being deionized water;

[0136] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 2% nano silica, 1% nano titanium dioxide, 0.5% nano tallosite, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0137] In this embodiment, the foaming agent is a mixture of octylalkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0138] This embodiment prepares a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method embodiment 3.

[0139] Comparative Example 1

[0140] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, control stabilizer 2%, and the balance being deionized water;

[0141] In this embodiment, the stabilizer is controlled by the following components at a mass fraction of 100%: 2% nano silica, 1% nano titanium dioxide, 0.5% nano tallosite, 20% polyether epoxy modified silicone oil, 30% polysiloxane-polyether copolymer, and the remaining solvent is triethylene glycol and water mixed in a 1:5 ratio.

[0142] This comparative example prepared a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method example 3.

[0143] Comparative Example 2

[0144] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated mass percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, and the balance being deionized water;

[0145] In this embodiment, the foaming agent is a mixture of hexylalkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0146] This comparative example prepared a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method example 3.

[0147] Comparative Example 3

[0148] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated mass percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 1%, and the balance being deionized water;

[0149] In this embodiment, the foaming agent is a mixture of hexylalkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0150] This comparative example prepared a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method example 3.

[0151] Comparative Example 4

[0152] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, fatty alcohol 2%; the balance is deionized water.

[0153] In this embodiment, the foaming agent is a mixture of hexylalkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0154] This comparative example prepared a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method example 3.

[0155] Comparative Example 5

[0156] A glutaraldehyde-decylmethylammonium bromide solution foam disinfectant is made from the following raw materials in the indicated weight percentages: glutaraldehyde 5%, decylmethylammonium bromide 5%, foaming agent 5%, sodium bromide 2%; the balance is deionized water.

[0157] In this embodiment, the foaming agent is a mixture of hexylalkyl glycoside, dodecyl dimethylamine oxide, hexadecyl dimethylamine oxide, dodecyl dimethyl betaine, and fatty alcohol polyoxyethylene ether-9 in a mass ratio of 2:0.1:0.9:1:1.

[0158] This comparative example prepared a glutaraldehyde-decylmethylammonium bromide solution foam disinfectant according to method example 3.

[0159] Performance identification

[0160] Samples: Disinfectants obtained from Examples 1-14 and Comparative Examples 1-5.

[0161] Blank sample: Prepare a glutaraldehyde-decyl bromide solution by mixing 5% glutaraldehyde and 5% decyl bromide with the remainder in water.

[0162] Take appropriate amounts (approximately equivalent to 0.3 g of decanemethylammonium bromide) of the disinfectant samples and blank samples obtained in Examples 1-14 and Comparative Examples 1-5, place them in test tubes respectively, add 30 ml of water to prepare the test solutions. Take 20 ml of each test solution, add a few drops of saturated trinitrophenol solution, and observe the changes in the test tubes.

[0163] Take another 10 ml of the test solution, add 1 ml of dilute nitric acid, and observe whether a white precipitate forms. If a white precipitate forms, filter the solution. Once the filtrate is clear, add 2-4 drops of silver nitrate to the clear filtrate, gently shake, and let it stand. Observe whether a pale yellow precipitate forms at the bottom of the test tube, indicating that the filtrate shows the identification reaction for bromide. If all phenomena occur, the product is qualified. If no reaction occurs in any of the intermediate steps, the product is unqualified. The test results are shown in Table 1.

[0164] Table 1. Results of identification using glutaraldehyde-decylmethylammonium bromide solution

[0165]

[0166] As can be seen from Table 1, the blank sample and the foam disinfectant obtained in Examples 1-14 showed a pale yellow precipitate when saturated trinitrophenol was added in the identification method; a white precipitate when dilute nitric acid was added; and a pale yellow precipitate when silver bromide was added to the filtrate. This indicates that the control stabilizer and foaming agent added to the foam disinfectant obtained in Examples 1-14 did not affect the identification of decyl bromide in the solution.

[0167] Comparing the foam disinfectant obtained in Example 13 with Comparative Examples 1-5, Comparative Example 1, without adding any foaming agent but only adding a control agent, showed phenomena when identifying decyl bromide, indicating that it met the identification criteria. This suggests that the control stabilizer added in this invention has no effect on the qualified identification of decyl bromide. In Comparative Example 2, a large amount of foaming agent was added, and no control stabilizer was present, yet no corresponding precipitation phenomenon was observed in the test results, indicating that it affected the identification of decyl bromide. In Comparative Example 3, only the foaming agent content was reduced, and no control stabilizer was added, indicating that the presence of a small amount of foaming agent (i.e., conventional amphoteric surfactants and nonionic surfactants) has little effect on the identification of decyl bromide. Comparative Examples 4 and 5 both added a large amount of foaming agent, and simultaneously added fatty alcohol and sodium bromide as control stabilizers, respectively. Because the addition of fatty alcohol reduced the surface tension of the system, it reduced the solubilizing effect of the foaming agent on decyl bromide, and the addition of sodium bromide offset the solubilizing effect of the foaming agent on decyl bromide, phenomena were observed during identification in both examples.

[0168] Second foam stability

[0169] Disinfectants prepared in Examples 1-14, blank samples, Comparative Examples 1, 3, 4, and 5 (Comparative Example 2 was not evaluated in the following experiments because the product failed the identification test) were diluted to a 1% glutaraldehyde-decylmethylammonium bromide solution. These solutions were then mixed with tap water at a volume ratio of 1:100. Simulating an on-site foaming device, foam was sprayed using a high-pressure (0.7 MPa) foam gun. After the foam stabilized, the foaming ratio N and the half-life t of the separated liquid were tested using a funnel with a liquid-holding cylinder. Simultaneously, the foam adhesion time T (the time it takes for the foam to remain on approximately half the surface of the vertical glass plate) was tested. Each group underwent three experimental tests, and the average value was taken. Specific results are shown in Table 2 below (test temperature: 20℃-28℃).

[0170] Table 2. Foaming performance and wall-hanging time of disinfectant diluted 100 times.

[0171]

[0172] Foam performance typically includes foaming properties and foam stability. Foam stability is generally evaluated by the foam height half-life and the liquid separation half-life. Different foaming methods and test conditions affect foam performance, including foam stability. Therefore, by further evaluating the time it takes for the foam to adhere to the vertical plate surface, we can indirectly reflect its effectiveness in applications.

[0173] As can be seen from Table 2, the addition of a control stabilizer is crucial for maintaining foam stability and wall adhesion. Compared to the blank sample, Comparative Example 1, Comparative Example 3, Comparative Example 4, and Comparative Example 5, Examples 1-14 show significantly improved foam expansion ratio, liquid separation half-life, and foam wall adhesion. Examples 9 and 13, in particular, exhibit excellent performance in terms of foam expansion ratio, liquid separation half-life, and liquid separation half-life. This indicates that the combination of foaming agent and control stabilizer effectively improves foam adhesion and foam stability. The blank sample, due to the good foaming properties of decyl bromide, suffers from poor foam stability. The addition of a control stabilizer in Comparative Example 1 improves the foam stability of the solution to some extent, but also affects the foaming performance. In Comparative Examples 3, 4, and 5, the addition of foaming agents improved the foam expansion ratio and foam separation half-life to some extent. However, the improvement in foam adhesion did not meet the ideal requirements, indicating that a single foaming agent has poor foam stability and adhesion. In contrast, the combined use of stabilizers and foaming agents can effectively increase foam stability.

[0174] Storage stability and laboratory sterilization

[0175] (1) Storage stability test

[0176] The samples from Examples 1-14, the blank sample, Comparative Examples 1, 3, 4, and 5 were placed into sample vials, sealed, and placed in constant temperature ovens at 54±2℃ and 25±2℃. The appearance, pH value, glutaraldehyde content, and decyl bromide content of the samples were observed on day 14. The results are shown in Table 3.

[0177] Table 3 Comparison of storage stability properties of glutaraldehyde-decylmethylammonium bromide foam disinfectant

[0178]

[0179] As shown in Table 3, after the test ended (day 14), the content of glutaraldehyde and pH value in the foam disinfectant solution showed a decreasing trend, while the content of decyl bromide maintained a slight increasing trend. The color of the solution gradually changed from colorless to light yellow, yellow and dark yellow.

[0180] Compared with Examples 1-14 and the blank sample, Comparative Examples 1, 3, 4, and 5, after being stored at 54°C for 14 days, showed significant changes in solution appearance, pH, and glutaraldehyde content, except for the content of decanted methane bromide. These changes exceeded the quality standards for glutaraldehyde-decanoic acid-ammonium bromide solutions (pH 3-6; glutaraldehyde and decanted methane bromide content 90%-110%; solution color: colorless to pale yellow). Among these, Comparative Example 5 showed the greatest changes in solution color and pH. Comparative Examples 3, 4, and 5 showed significant decreases in the effective component glutaraldehyde, from 5.05% to 3.14%, 3.35%, and 3.68%, respectively. Examples 1-14 and the blank sample, however, met the quality standards for glutaraldehyde-decanoic acid-ammonium bromide solutions in terms of pH, glutaraldehyde content, decanted methane bromide content, and appearance. Example 9, after being stored at 54°C for 30 days, showed the least change in the effective component pH, glutaraldehyde content, and decanted methane bromide content, indicating that Example 9 of the present invention has the best storage stability.

[0181] (2) Laboratory sterilization test

[0182] The foam disinfectant samples prepared in Examples 1-14, blank samples, comparative examples 1, 3, 4, and 5 were subjected to sterilization and disinfection experiments before and after aging.

[0183] In accordance with the relevant provisions of the "Disinfection Technical Specifications" and the "National Food Safety Standard for Microbiological Examination of Food: Determination of Total Colony Count", the bacteria (Staphylococcus aureus, Escherichia coli, and hemolytic streptococci group C) were passaged to 6-8 generations using the 10-fold dilution method, and then diluted with PBS solution to a concentration of 5×10⁻⁶. 6 CUF / mL bacterial suspension. Decyl bromide glutaraldehyde foam disinfectant (glutaraldehyde concentration: 1%; dedecyl bromide concentration: 1%) was diluted to a concentration of 1:1000 with sterile distilled water. 2.5 mL of the test bacterial suspension was added to each tube, mixed well, and placed in a 20℃ water bath. Every 3, 5, 10, 15, 30 min, and 60 min, 0.5 mL from each tube was added to 4.5 mL of Martin broth containing neutralizing agent and shaken well. After neutralization for 10 min, another 0.5 mL was added to 4.5 mL of Martin broth medium and incubated at 37℃ for 24 h. Bacterial growth was observed. Turbidity indicated bacterial growth; no turbidity was observed. Incubation continued until day 7. If no turbidity was observed, sterile growth was considered. The results are shown in Table 4.

[0184] Table 4. Results of qualitative tests on bacteria using decyl bromide glutaraldehyde foam disinfectant.

[0185]

[0186] Note: 1) In Table 4, A, B, and C represent Staphylococcus aureus, Escherichia coli, and hemolytic streptococcus, respectively; 2) In Table 4, "+" indicates bacterial growth; "-" indicates no bacterial growth; 3) The test temperature is 20℃; 4) The test results are the average of 5 tests.

[0187] As shown in Table 4, the foam disinfectant samples from Examples 1-14, especially Examples 9 and 13, exhibited better bactericidal disinfection against the three bacterial colonies than the blank sample and the comparative examples. The results in Table 4 show that when the decanted methyl bromide glutaraldehyde foam disinfectant from Examples 1-14 was diluted 1:1000, no bacteria were generated within 3 minutes, indicating that it effectively killed Staphylococcus aureus, Escherichia coli, and hemolytic streptococci within 3 minutes. The blank sample, the decanted methyl bromide glutaraldehyde solution, showed no bacterial growth starting at 5 minutes, indicating that it effectively killed Staphylococcus aureus, Escherichia coli, and hemolytic streptococci within 5 minutes. However, comparative examples 1, 3, 4, and 5, when diluted 1000 times, all showed bacterial growth within 60 minutes, indicating that they were not effective against Staphylococcus aureus, Escherichia coli, and hemolytic streptococci.

[0188] Disinfection and cleaning performance tests at four farms

[0189] (1) Disinfection and sterilization performance test

[0190] A large pig farm in Sichuan Province was selected for disinfection. The pig farm had cement walls and floors. After cleaning and rinsing with tap water, and drying, foam was generated under pressure using a foam gun and sprayed onto the disinfection area (using the same concentration and amount of glutaraldehyde-decylmethylammonium bromide solution). The decylmethylammonium bromide-glutaraldehyde foam disinfectant was prepared with tap water (without other disinfectants) to a 1% concentration. After spraying, doors and windows were closed for 1 hour. Before and after disinfection, five points were swabbed on the walls of different pig farms using cotton swabs to obtain the average bacterial count before and after disinfection. Specifically, a 5cm × 5cm area was swabbed five times at each sampling point, while rotating the swab. The swab was then placed in the neutralizing solution and shaken vigorously 100 times. The washings were cultured on blood nutrient agar plates for viable bacterial count. The viable bacteria from the five sampling points were averaged to obtain the average colony count after disinfection. The sterilization rate is calculated based on the average bacterial count of the samples before and after sterilization. The formula for calculating the sterilization rate is:

[0191] The data results are shown in Table 5:

[0192] Table 5. Test results of disinfection and sterilization performance in livestock farms

[0193]

[0194] As shown in Table 5, the order of disinfection and sterilization effects from greatest to least is: Example 9 > Example 13 > Example 6 > Example 1 > Blank sample > Control group. Example 9 has the best disinfection and sterilization effect.

[0195] (2) Cleaning and decontamination performance test

[0196] Similar to disinfection and sterilization tests, a cleaning performance test was conducted on the cement walls of pigsties in a pig farm. The pigsties were first cleaned and rinsed with tap water. After drying, foam was created using a foam gun under certain pressure conditions. The foam was then sprayed onto the disinfection area (using a glutaraldehyde-decanoic acid solution of the same concentration and dosage). The decanoic acid-glutaraldehyde foam disinfectant was prepared at a 1% concentration with tap water (without other disinfectants). After spraying, the doors and windows were closed for 1 hour, and the wall surface was observed. Figures 1-5 As shown in Table 6, samples were taken from the same point or area of ​​the wall surface before and after cleaning, decontamination, and disinfection. The number of contaminants or microorganisms in the samples was determined using a 3M ATP fluorescence detector (detection mode RUL) to evaluate the cleaning and decontamination performance of the farm walls.

[0197] Table 6. Test Results of Cleaning and Decontamination Performance in Livestock Farms

[0198]

[0199] Table 6 shows that the foam disinfection results obtained in Examples 1, 6, 9, and 13 showed low levels of microbial content on the solid surface after on-site cleaning and decontamination, indicating good cleaning and decontamination effects. The results show that the cleaning and decontamination performance, from best to worst, is: Example 9 > Example 13 > Example 6 > Example 1 > Blank sample. Example 9 showed the best cleaning effect, demonstrating that the combination of the control stabilizer and foaming agent added in this invention can effectively improve the cleaning performance of the glutaraldehyde-decylmethylammonium bromide solution.

[0200] This invention demonstrates that the combination of control stabilizer and foaming agent can improve the foam stability and foaming performance of glutaraldehyde-decylmethylammonium bromide solution, improve foam adhesion to walls, enhance disinfection and sterilization effects, reduce dosage, and provide important reference and guidance for developing more efficient and environmentally friendly foam sterilization and disinfection technologies.

[0201] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of the invention. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0202] Finally, it should be noted that the embodiments disclosed in this invention are merely preferred embodiments of this invention and are only used to illustrate the technical solutions of this invention, not to limit it. Although this invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this invention.

Claims

1. A glutaraldehyde decamethonium bromide solution foam disinfectant characterized by: Made from the following raw materials by weight percentage: glutaraldehyde 3%-10%, decyl bromide 3%-10%, foaming agent 1%-5%, control stabilizer 0.5%-3%, optional pH adjuster, and the balance being deionized water; The control stabilizer is a composition formed from nanomaterials, organosiloxanes, and solvents, wherein the control stabilizer comprises, by mass percentage: 0.1-5% nanomaterials, 40%-60% organosiloxanes, and the balance being solvent; the nanomaterials are one or more of silicon dioxide, titanium dioxide, and halloysite; the organosiloxanes are one or more of polyether-modified amino silicone oil, polyether-epoxy-modified silicone oil, and epoxy-modified polymethylsiloxanes. The foaming agent is one or more of amphoteric surfactants and nonionic surfactants; the amphoteric surfactant is one or more of fatty alkyl amine oxides and alkyl methyl betaine; the nonionic surfactant is any one or more of alkyl glucose, fatty alcohol polyoxyethylene ether, fatty acid alcohol ester, and fatty acid alcohol ester polyoxyethylene ether.

2. The glutaraldehyde cetrimonium bromide solution foam disinfectant according to claim 1, characterized in that: The solvent is one or more of propylene glycol methyl ether, propylene glycol ethyl ether, propylene glycol propyl ether, propylene glycol butyl ether, dipropylene glycol methyl ether, diethylene glycol ethyl ether, diethylene glycol propyl ether, dipropylene glycol butyl ether, diethylene glycol butyl ether, glycerol butyl ether, diethylene glycol, butanol, triethylene glycol, and water.

3. The glutaraldehyde cetrimonium bromide solution foam disinfectant according to claim 1, characterized in that: The aliphatic alkyl amine oxide is any one or more of the alkyl amine oxides with a carbon chain length of C8-C18.

4. The glutaraldehyde cetrimonium bromide solution foam disinfectant according to claim 3, characterized in that: The fatty alkyl amine oxide is a mixture of C12 alkyl amine oxide and C16 alkyl amine oxide in a mass ratio of 9:1 to 1:

9.

5. A process for the preparation of a glutaraldehyde cetavlon solution foam disinfectant according to any one of claims 1 to 4, characterized in that: Includes the following steps: (1) First, mix glutaraldehyde and decyl bromide solution evenly, then add control stabilizer and continue stirring evenly, then add deionized water and stir evenly to obtain premixed solution A; (2) Continue stirring and mixing the premixed solution A with the foaming agent until the solution presents a homogeneous and transparent mixture B; (3) Add pH adjuster as needed to adjust the pH of mixture B to 3.0-6.0 to obtain the finished product glutaraldehyde decyl bromide solution foam disinfectant.

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