A filling system and control method for ampoule and penicillin bottle

Abstract

An ampoule and a penicillin bottle integrated filling system and operation method belong to the technical field of biological medicine equipment. It comprises feeding net belt assembly, feeding screw rod assembly, feeding star wheel assembly, inlet plum blossom star wheel, needle rack assembly, outlet plum blossom assembly, sampling and rejecting assembly, discharging screw rod assembly and control system arranged in sequence. The control system is connected with the feeding net belt assembly, the feeding screw rod assembly, the filling system assembly, the needle rack assembly, the fire rack assembly, the wire drawing assembly, the rubber plug feeding system assembly, the plug pressing assembly and the discharging screw rod assembly respectively. The two kinds of filling systems of ampoule and penicillin bottle are combined together, the floor area of the filling system is significantly reduced, it can be installed in different types of factory buildings, and the applicability is stronger.

Description

Technical Field

[0001] This invention relates to an integrated ampoule and vial filling system and control method, belonging to the field of biomedical equipment technology. The direction mentioned in this invention is defined as a direction perpendicular to the horizontal plane from top to bottom. Background Technology

[0002] Currently, existing filling machines in the pharmaceutical equipment market can only meet the filling needs of vials or ampoules individually. However, with the increasing demand for diverse product packaging materials, a multi-functional filling machine capable of filling both vials and ampoules is becoming increasingly important. Therefore, this technical field urgently needs an integrated ampoule and vial filling system that can simultaneously accommodate the filling needs of both. By simply changing the mold specifications and adjusting the filling program, it can meet the filling requirements of different types and shapes of bottles, thus achieving a dual-purpose function. Summary of the Invention

[0003] The purpose of this invention is to solve the technical problem of how to obtain an integrated ampoule and vial filling system that can simultaneously meet the filling needs of both ampoules and vials.

[0004] To address the aforementioned problems, the present invention provides an integrated ampoule and vial filling system, comprising, in sequence, a feeding conveyor belt assembly, a feeding screw assembly, a feeding star wheel assembly, an inlet star wheel, a needle holder assembly, an outlet star wheel assembly, a sampling and rejection assembly, a discharge screw assembly, and a control system; a filling system assembly is located adjacent to the needle holder assembly; a bottle feeding assembly and a bottle protection assembly are located adjacent to the inlet star wheel; a flame holder assembly and a stringing assembly are located between the needle holder assembly and the outlet star wheel assembly; a rubber stopper feeding system assembly and a stoppering assembly are located adjacent to the outlet star wheel assembly; an ampoule discharge assembly and a vial discharge assembly are located at the outlet end of the discharge screw assembly; and the control system is connected to the feeding conveyor belt assembly, the feeding screw assembly, the filling system assembly, the needle holder assembly, the flame holder assembly, the stringing assembly, the rubber stopper feeding system assembly, the stoppering assembly, and the discharge screw assembly.

[0005] Furthermore, it includes a working platform and an isolation wall surrounding the working platform, the isolation wall, the working platform, and the ceiling forming an isolation space, the operating parts of each component in the filling system are on the working platform, and the drive and power supply parts are located below the working platform.

[0006] Furthermore, the feed conveyor belt assembly stores and transports ampoules or vials input from the upstream process to the feed star wheel assembly.

[0007] Furthermore, the feeding conveyor belt assembly includes a first fence, a second fence, a feeding conveyor belt, and an arc-shaped tensioning spring; the first fence, the second fence, and the feeding screw assembly form a "U" shape, with its opening facing the upstream feed inlet; a transport conveyor belt is also laid flat inside the first fence, the second fence, and the feeding screw assembly, with its transport direction perpendicular to the axial direction of the feeding screw; the arc-shaped tensioning spring is vertically arranged on the feeding conveyor belt, with one side connected to the first fence and the other side connected to the second fence.

[0008] Furthermore, the needle holder assembly is equipped with a servo motor and a transmission screw for moving up and down in coordination with the filling system assembly to perform nitrogen filling and filling operations on the packaging material.

[0009] Furthermore, the filling system components are connected to the fire rack assembly and the wire drawing assembly via a control system.

[0010] Furthermore, a rotating bottle assembly is provided between the fire frame assembly and the drawing assembly. The rotating bottle assembly includes a rotating bottle base and a turntable with a rotating shaft protruding above the rotating bottle base. A first drive rod is connected below the rotating bottle base. The first drive rod is connected to a first drive wheel. The first drive wheel is connected to a first servo motor. The first servo motor can drive the first drive wheel to rotate, thereby driving the turntable to rotate.

[0011] Furthermore, the flame holder assembly includes a nozzle holder with a nozzle orifice on its upper side and a second drive rod connected to the lower side of the nozzle holder. The second drive rod is connected to a second drive wheel, and the rotation of the second drive wheel can drive the second drive rod to move up and down. The second drive wheel is connected to a second servo motor. The bottle rotating assembly is located on one side of the nozzle orifice of the flame holder assembly. The second servo motor drives the nozzle holder to move downward and can align the nozzle orifice with the neck of the ampoule located on the turntable.

[0012] Furthermore, the second drive wheel is provided with a first drive swing arm and a second drive swing arm. One side of the first drive swing arm and the second drive swing arm are hinged to each other, and the other side of the first drive swing arm and the second drive swing arm are connected to the adjacent side of the second drive wheel. The lower part of the second drive rod is connected to the first drive swing arm.

[0013] Furthermore, the wire drawing assembly includes a wire drawing frame, on which a rotating component is provided, and on which wire drawing clamps are provided. A third drive rod is connected to the lower side of the wire drawing frame, and a third drive wheel is connected to the third drive rod. The rotation of the third drive wheel can drive the third drive rod to move up and down. A third servo motor is connected to the third drive wheel. The third servo motor drives the wire drawing frame to move up and down.

[0014] Furthermore, a sealing housing is provided behind the wire drawing frame. The sealing housing includes a first sealing container and a second sealing container fixedly connected vertically. The upper section of the third drive rod is disposed in the first sealing container, and the lower end of the third drive rod is disposed in the second sealing container. A first through hole for the third drive rod to pass through is provided at the junction of the first sealing container and the second sealing container. A spring is sleeved on the upper section of the third drive rod. The diameter of the spring and the area of ​​the upper end of the third drive rod are larger than the diameter of the through hole. The lower edge of the sealing housing abuts against the top of the work platform. A second through hole for the third drive rod to pass through is provided on the lower edge, and a sealing O-ring is provided at the junction of the sealing housing and the second through hole.

[0015] Furthermore, the rotating assembly also includes a main support, and a first rotating shaft, a second rotating shaft, and a third rotating shaft rotatably connected within the main support. The first rotating shaft and the second rotating shaft are arranged side by side below the third rotating shaft. The wire drawing clamp consists of several single-sided components respectively arranged facing each other on the first rotating shaft and the second rotating shaft. The same side of the first rotating shaft and the second rotating shaft are rotatably connected to the main support through mutually meshing first gears. The wire drawing clamp is opened or closed by rotating the first rotating shaft and the second rotating shaft. The third rotating shaft allows the rotating assembly to flip to one side. A damping structure is embedded in the end of the main support near the first gear side. The first gear end of the first rotating shaft is wound with one side of the first steel strand, and the other side of the first steel strand is wound around the top of the third drive rod. The end of the third rotating shaft is wound with one side of the second steel strand, and the other side of the second steel strand is wound around the top of the third drive rod. A third steel strand and a fourth steel strand are connected between the bottom of the third drive rod and the third drive wheel.

[0016] Furthermore, the third drive wheel, facing the third servo motor, sequentially includes a clamping cam, a swing frame cam, and an opening cam; the clamping cam drives the wire drawing frame to move up and down; the swing frame cam, connected to the fourth steel strand, drives the clamp to swing back and forth; the opening cam, connected to the third steel strand, drives the wire drawing clamp to open or close; the third drive rod includes a left drive rod and a right drive rod, the upper side of the left drive rod is connected to the first steel strand, and the lower side is connected to the third steel strand, the upper side of the right drive rod is connected to the second steel strand, and the lower side is connected to the fourth steel strand.

[0017] Furthermore, an "L"-shaped guide plate and a guide wheel are provided in the direction of the steel strand leading to the drive wheel. One side of the guide plate is connected to the lower side of the sealing housing, and the other side is connected to the third drive wheel. The third steel strand and the fourth steel strand bypass the guide wheel and are connected to the third drive wheel.

[0018] Furthermore, a shrink rod assembly is provided between the clamping cam and the wire drawing frame. The shrink rod assembly includes a shrinking shell and a displacement rod that can move up and down inside the shrinking shell. A support platform is provided at the upper end of the displacement rod. The rod body of the displacement rod relies on the clamping cam. By utilizing the self-rotation of the clamping cam, the displacement rod is driven to move up or down.

[0019] Furthermore, a slag discharge assembly is provided opposite the fire frame assembly; the slag discharge assembly includes a first slag discharge channel with an opening at the top, a sealed chamber connected below the first slag discharge channel, a movable base plate provided in the sealed chamber, a base plate drive rod provided on one side of the movable base plate, the base plate drive rod passing through the side wall of the sealed chamber and connected to an external drive cylinder, the drive cylinder being fixedly connected to a limiting plate; a second slag discharge channel is provided below the movable base plate, a sealed slag box is provided at the outlet of the second slag discharge channel, the slag box has an opening above it communicating with the outlet of the second slag discharge channel and is sealed to the second slag discharge channel, a track is laid at the bottom of the slag box, a slag trolley with rollers is provided on the track, the slag trolley is used to receive the residue falling from the second slag discharge channel, a sealed front door is provided on the front side of the slag box, the sealed front door is paired with a sensor, when the sensor senses that the sealed front door is open, it notifies the control system to drive the cylinder to close the movable base plate, when the sensor senses that the sealed front door is closed, it restores the movable base plate to its initial open state.

[0020] Furthermore, the slag discharge assembly is equipped with an exhaust assembly, which includes a fan hopper, a pneumatic butterfly valve, and a heat exhaust channel connected sequentially from bottom to top; a heat exhaust fan and a fan housing disposed outside the heat exhaust fan are disposed together on one side of the heat exhaust channel.

[0021] Furthermore, the filling system assembly is connected to the stopper feeding system assembly and the stopper pressing assembly via a control system.

[0022] Furthermore, the filling system components are connected to the discharge screw assembly via a control system; the discharge screw assembly is connected to either the ampoule discharge assembly or the vial discharge assembly.

[0023] Furthermore, a filling control method for an integrated ampoule and vial: This control method is based on any of the above-mentioned integrated ampoule and vial filling systems. When the container to be filled is an ampoule, the ampoule filling mode is activated through the control system. The screw component of the feed screw assembly, the gear component of the feed star wheel assembly, the guardrail component of the bottle protection assembly, the gear component of the inlet star wheel, and the gear component of the outlet star wheel assembly are replaced to suit the operation of the ampoule. In the ampoule filling mode, the control system controls the operation of the feed conveyor belt assembly, feed screw assembly, feed star wheel assembly, inlet star wheel, filling system assembly, needle holder assembly, flame holder assembly, wire drawing assembly, outlet star wheel assembly, discharge screw assembly, and ampoule discharge assembly.

[0024] When the container to be filled is a vial, the vial filling mode is activated through the control system. The screw of the feed screw assembly, the gear of the feed star wheel assembly, the guardrail of the bottle guard assembly, the gear of the inlet star wheel, and the gear of the outlet star wheel assembly are replaced to suit the operation of the vial. In the ampoule filling mode, the control system controls the operation of the feed conveyor belt assembly, feed screw assembly, feed star wheel assembly, inlet star wheel, filling system assembly, needle holder assembly, outlet star wheel assembly, rubber stopper feeding system assembly, stopper pressing assembly, discharge screw assembly, and vial discharge assembly.

[0025] The feeding conveyor belt assembly transports the containers to the feeding screw assembly. The feeding screw assembly changes the transport direction of the containers, transporting them one by one to the feeding star wheel assembly. The feeding star wheel assembly rotates, transporting the containers to the inlet star wheel. The inlet star wheel transports the containers to the filling system assembly and needle holder assembly for nitrogen filling and medication administration. The bottle delivery assembly and bottle protection assembly hold the containers in the grooves of the bottle delivery assembly and protect them with the guardrails of the bottle protection assembly, transporting the containers to the relevant process components for processing. Finally, the discharge screw assembly transports the containers to the corresponding outlet.

[0026] The fire rack assembly heats the neck of the ampoule to melt it, and the wire drawing assembly throws the residue from the ampoule to the slag discharge assembly.

[0027] The stopper feeding system assembly is used to store the stopper cap. The stopper cap is rotated inside the container and then fed to the upper part of the stoppering assembly. When the vial is fed to the lower part of the stoppering assembly, the stoppering assembly presses down to seal the stopper cap at the upper end of the vial.

[0028] The beneficial effects of this plan are:

[0029] This invention cleverly combines two filling systems, ampoule and vial, significantly reducing the floor space required for the filling system. It can be installed in different types of factories, making it more versatile.

[0030] This invention incorporates sealing devices in the wire drawing assembly, slag removal assembly, and venting assembly, ensuring that the cleanliness requirements of the ampoule filling equipment meet those of vial filling. This allows for a single system suitable for two different bottle types. Attached Figure Description

[0031] Other features, objects, and advantages of the invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0032] Figure 1 This is a schematic diagram of an integrated ampoule and vial filling system according to an embodiment of the present invention;

[0033] Figure 2 This is a schematic diagram of the feeding conveyor belt assembly in an embodiment of the present invention;

[0034] Figure 3 This is a schematic diagram of the structure of the fire frame assembly, the wire drawing assembly, and the bottle rotating assembly in an embodiment of the present invention. Figure 1 ;

[0035] Figure 4 This is a schematic diagram of the structure of the fire frame assembly, the wire drawing assembly, and the bottle rotating assembly in an embodiment of the present invention. Figure 2 ;

[0036] Figure 5 This is a schematic diagram of the wire drawing assembly in an embodiment of the present invention. Figure 1 ;

[0037] Figure 6 This is a schematic diagram of the wire drawing assembly in an embodiment of the present invention. Figure 2 ;

[0038] Figure 7 This is a schematic diagram of the structure of the sealing shell in an embodiment of the present invention;

[0039] Figure 8 This is a schematic diagram of the rotating component in an embodiment of the present invention;

[0040] Figure 9 for Figure 8 A partial structural diagram of section A in the middle;

[0041] Figure 10 This is a schematic diagram of the slag discharge assembly in an embodiment of the present invention. Figure 1 ;

[0042] Figure 11 This is a schematic diagram of the slag discharge assembly in an embodiment of the present invention. Figure 2 ;

[0043] Figure 12 This is a schematic diagram of the exhaust assembly in an embodiment of the present invention. Figure 1 ;

[0044] Figure 13 This is a schematic diagram of the exhaust assembly in an embodiment of the present invention. Figure 2 ;

[0045] Figure 14 This is a schematic diagram of the structure of the bottle rotating assembly in an embodiment of the present invention;

[0046] Figure 15 This is a schematic diagram of the needle holder assembly in an embodiment of the present invention;

[0047] Figure 16 This is a schematic diagram of the wire drawing assembly in an embodiment of the present invention. Figure 3 ;

[0048] Figure 17 This is a schematic diagram of the fire frame assembly in an embodiment of the present invention;

[0049] Explanation of reference numerals in the attached drawings: 1. Feeding mesh belt assembly; 101 First fence; 102 Second fence; 103 Conveyor mesh belt; 104 Arc-shaped tension spring; 105 Feed inlet; 2. Feeding screw assembly; 3. Feeding star wheel assembly; 4. Inlet plum blossom star wheel; 5. Bottle feeding assembly; 6. Bottle protection assembly; 7. Filling system assembly; 8. Needle holder assembly; 9. Flame holder assembly; 901. Nozzle holder; 902. Nozzle outlet; 903. Second drive rod; 904. Second drive wheel; 905. Second servo motor; 906. First drive swing arm; 907. Second drive swing arm; 10. Wire drawing assembly; 1001. Wire drawing frame; 1002. Rotation assembly; 10021. Main support; 10022. First rotating shaft; 10023. Second rotating shaft; 10024. Third rotating shaft; 10025. First gear; 10026. Damping Structure; 1003. Wire drawing clamp; 1004. Third drive rod; 10041. Left drive rod; 10042. Right drive rod; 1005. Third drive wheel; 10051. Clamping cam; 10052. Swing frame cam; 10053. Clamping cam; 1006. Third servo motor; 11. Outlet plum blossom assembly; 12. Rubber stopper feeding system assembly; 13. Stopper pressing assembly; 14. Sampling and waste rejection assembly; 15. Discharge screw assembly; 16. Ampoule discharge assembly; 17. Vial discharge assembly; 18. Working platform; 19. Isolation wall; 20. Rotating bottle assembly; 201. Rotating bottle base; 202. Turntable; 203. First drive rod; 204. First drive wheel; 205. First servo motor; 21. Sealing shell; 211. First sealing container; 212. Second sealing container; 213. First through hole; 216. Sealing O-ring; 217. First steel strand; 218. Second steel strand; 219. Third steel strand; 220. Fourth steel strand; 221. Guide plate; 222. Guide wheel; 223. Retraction rod assembly; 224. Retraction shell; 225. Displacement rod; 226. Support platform; 23. Slag discharge assembly; 231. First slag discharge channel; 232. Sealed chamber; 233. Movable base plate; 234. Base plate drive rod; 235. Drive cylinder; 236. Limiting plate; 237. Second slag discharge channel; 238. Sealed slag box; 239. Track; 240. Slag trolley; 241. Sealed front door; 242. Sensor; 25. Exhaust assembly; 251. Air hopper; 252. Pneumatic butterfly valve; 253. Exhaust fan; 254. Fan housing; 255. Exhaust channel. Detailed Implementation

[0050] The present invention will now be described in further detail with reference to the accompanying drawings.

[0051] Other embodiments of the invention will readily occur to those skilled in the art upon consideration of the specification and practice of the invention disclosed herein. This application is intended to cover any variations, uses, or adaptations of the invention that follow the general principles of the invention and include common knowledge or customary techniques in the art not disclosed herein. The specification and examples are to be considered exemplary only, and the true scope and spirit of the invention are indicated by the claims.

[0052] The container bottle described in this invention includes either an ampoule or a vial, or both.

[0053] like Figure 1 As shown, the present invention provides an integrated ampoule and vial filling system, comprising, in sequence, a feeding mesh belt assembly 1, a feeding screw assembly 2, a feeding star wheel assembly 3, an inlet star wheel 4, a needle holder assembly 8, an outlet star wheel assembly 11, a sampling and waste rejection assembly 14, a discharge screw assembly 15, and a control system; a filling system assembly 7 is provided adjacent to the needle holder assembly 8; a bottle feeding assembly 5 and a bottle protection assembly 6 are provided adjacent to the inlet star wheel 4; a flame holder assembly 9 and a wire drawing assembly 10 are provided in sequence between the needle holder assembly 8 and the outlet star wheel assembly 11; a rubber stopper feeding system assembly 12 and a stopper pressing assembly 13 are provided adjacent to the outlet star wheel assembly 11; and an ampoule discharge assembly 16 and a vial discharge assembly 17 are respectively provided at the outlet end of the discharge screw assembly 15. In this embodiment, the ampoule filling system and the vial filling system are cleverly combined into one system. The feeding conveyor belt assembly 1, the feeding screw assembly 2, the feeding star wheel assembly 3, the inlet star wheel 4, the needle holder assembly 8, the outlet star wheel assembly 11, the sampling and rejection assembly 14, and the discharge screw assembly 15 are connected adjacently from one side to the other. This not only efficiently realizes the feeding, filling, and sealing of various bottle types, but also further reduces the floor space of the production system by arranging the devices in pairs, making it suitable for more workplace scenarios.

[0054] Furthermore, the system includes a work platform 18 and an isolation wall 19 surrounding the work platform 18. The isolation wall 19, the work platform 18, and the ceiling form an isolation space. The operating parts of each component in the filling system are located on the work platform 18, and the drive and power supply parts are located below the work platform 18. In this embodiment, since ampoules and vials are to be filled in one system, but the filling of vials requires a higher level of environmental cleanliness than that of ampoules, the cleanliness requirements for ampoule filling need to be increased to accommodate the cleanliness requirements of the two different bottle types. The work platform 18 and the isolation wall 19, which are typically made of transparent glass, along with the ceiling or the top of the building itself, constitute a physical isolation, forming a partially sealed state. Each component operates within this isolation space, achieving the required cleanliness for component operation. Operators can intervene as necessary using gloves and through open windows.

[0055] The control system is connected to the feeding conveyor belt assembly 1, the feeding screw assembly 2, the filling system assembly 7, the needle holder assembly 8, the flame holder assembly 9, the stringing assembly 10, the rubber stopper feeding system assembly 12, the stopper pressing assembly 13, and the discharge screw assembly 15. The feeding conveyor belt assembly 1 stores and transports ampoules or vials from the upstream process to the feeding star wheel assembly 3. The needle holder assembly 8 is equipped with a servo motor and a drive screw for its up-and-down movement to coordinate with the filling system assembly 7 in nitrogen filling and packaging. The filling system assembly 7 is connected to the flame holder assembly 99 and the stringing assembly 10 via the control system. The filling system assembly 7 is also connected to the rubber stopper feeding system assembly 12 and the stopper pressing assembly 13 via the control system. The filling system assembly 7 is connected to the discharge screw assembly 15 via the control system; the discharge screw assembly 15 is connected to either the ampoule discharge assembly 16 or the vial discharge assembly 17. Example

[0056] like Figure 1-5 As shown, the purpose of this invention is to provide an integrated ampoule and vial filling system that can accommodate the filling needs of both ampoules and vials (two bottle types), achieving a dual-purpose filling function in one machine.

[0057] The present invention provides an integrated ampoule and vial filling system, comprising a feeding conveyor belt assembly 1, a feeding screw assembly 2, a feeding star wheel assembly 3, an inlet star wheel 4, a bottle feeding assembly 5, a bottle protection assembly 6, a filling system assembly 7, a needle holder assembly 8, a flame holder assembly 9, a stringing assembly 10, an outlet star wheel assembly 11, a rubber stopper feeding system assembly 12, a stopper pressing assembly 13, a sampling and waste rejection assembly 14, a discharge screw assembly 15, an ampoule discharge assembly 16, and a vial discharge assembly 17.

[0058] The functions of the above components are as follows:

[0059] The control system of this filling system has two preset filling modes: ampoule filling system and vial filling system. The staff selects the bottle type to be filled and starts the filling system.

[0060] The feed conveyor belt assembly 1 is used to store and transport packaging materials (ampoules or vials) that have been cleaned and sterilized from upstream via a bottle washing machine and a tunnel drying oven. The feed conveyor belt assembly stores the containers and can reduce the distance between two adjacent containers to make the containers touch. At the same time, the feed conveyor belt assembly transports containers input from the upstream process to the feed star wheel assembly.

[0061] like Figure 2 As shown, the feeding conveyor belt assembly 1 further includes a first fence 101, a second fence 102, a feeding conveyor belt, and an arc-shaped tensioning spring 104; the first fence 101, the second fence 102, and the feeding screw assembly 2 form a "U" shape, with its opening facing the upstream feed inlet 105; a transport conveyor belt 103 is also laid flat inside the first fence 101, the second fence 102, and the feeding screw assembly 2, with its transport direction perpendicular to the axial direction of the feeding screw; the arc-shaped tensioning spring 104 is vertically arranged on the feeding conveyor belt, with one side connected to the first fence 101 and the other side connected to the second fence 102. In this embodiment, since the integrated machine receives different bottle types from the discharge port, ampoules and vials, due to their different collision volumes and heights, may tip over if they are too loose or too tightly packed. This invention employs an arc-shaped tension spring 104, utilizing its elasticity to generate a certain low-amplitude vibration. When a bottle is pushed towards the arc-shaped tension spring 104, it is not only loosened by the vibration, but the arc shape also guides the bottle's movement more smoothly. Testing shows that it can effectively loosen not only ampoules but also vials, causing them to move towards the feed screw assembly 2. The movement of each bottle remains largely consistent, better adapting to the integrated machine provided by this invention. In this embodiment, the arc-shaped tension spring 104 is made of aluminum. Compared to the prior art that uses a vibrator to generate a vibration source to prevent bottle tipping, this invention only uses one spring, significantly reducing manufacturing costs.

[0062] The feed screw assembly 2 and the feed star wheel assembly 3 are used to convey the packaging materials from the feed mesh belt assembly 1, so that the ampoules or vials are arranged at equal intervals and conveyed to the feed star wheel assembly 3 at a uniform speed.

[0063] Furthermore, the feed screw assembly 2 includes at least a detachable feed screw, and the feed star wheel assembly 3, the inlet star wheel 4, and the sampling and rejection assembly 14 each include at least a detachable star wheel. In this embodiment, since the filling system needs to accommodate the transportation of ampoules and vials, which have different widths, the feed screw and star wheel need to be replaced according to the specific bottle type being transported, so that the size of the feeding troughs on their parts can match the width of the ampoules and vials. By simply replacing some parts, the system can accommodate the transportation of both bottle types, significantly reducing production costs and the floor space required for production equipment.

[0064] The inlet star wheel 4 can transport three sets of vials from the feed star wheel assembly 3 to the dispensing station in an intermittent motion.

[0065] Bottle feeding assembly 5 and bottle protection assembly 6 work together to intermittently transfer and transport packaging materials. Bottle protection assembly 6 transports the containers to the corresponding process handling units via the inlet star wheel assembly 4.

[0066] like Figure 15 As shown, the function of the needle holder assembly 8 is to coordinate with the filling system assembly 7 to perform nitrogen filling and filling operations on the packaging material through the up-and-down movement of the servo motor and transmission screw. The filling system assembly 7 selects different filling systems (peristaltic pump / plunger pump) according to different drug characteristics.

[0067] Furthermore, the filling system component 7 includes a first nitrogen-filling valve, a second nitrogen-filling valve, and a third nitrogen-filling valve. The first nitrogen-filling valve is a common valve according to the direction of bottle movement; the second nitrogen-filling valve is used for post-nitrogen filling of ampoules; and the third nitrogen-filling valve is used for post-nitrogen filling of vials. In this embodiment, regardless of whether it is an ampoule or a vial, the first nitrogen-filling valve needs to purge the air from the bottle; due to the different processes, the second nitrogen-filling valve only opens when the bottle type is an ampoule; similarly, the third nitrogen-filling valve only opens when the vial is used.

[0068] The filling pump used in this system is a peristaltic pump. Before production, the filling volume needs to be calibrated. When weighing the filled containers, if the filling volume differs significantly from the system's set volume, the tubing on the peristaltic pump needs to be replaced, and the capacity needs to be calibrated again.

[0069] After filling, the subsequent processes will differ depending on the bottle type, especially the sealing process. Ampoules and vials are sealed differently: ampoules are sealed by heating and drawing threads. Vials, however, require capping after filling, and the condition of the caps is then used to determine whether they need to be discarded.

[0070] like Figure 17 As shown, the function of the flame holder assembly 9 is as follows: when filling ampoules, the flame holder assembly 9 is activated by an electrical signal controlled by the filling program command issued by the control system to heat the upper part of the ampoule packaging material for a limited time by the flame emitted by the flame holder assembly 9; when filling vials, the flame holder assembly 9 does not activate.

[0071] like Figure 16 As shown, the function of the stringing component 10 is as follows: when filling ampoules, the stringing component 10 performs a sealing action according to the instructions given by the filling program issued by the control system, and performs stringing sealing on the ampoule after it has been heated by the flame holder; when filling vials, the stringing component 10 does not operate.

[0072] like Figure 3 , 4 As shown in Figures 5, 6, and 14, a rotating bottle assembly 20 is further provided between the fire frame assembly 9 and the drawing assembly 10. The rotating bottle assembly 20 includes a rotating bottle base 201 and a turntable 202 with a rotating shaft passing through the rotating bottle base 201. An opening for the turntable 202 to extend from the rotating bottle base 201 is provided on the rotating bottle base 201. The rotating shaft is connected to the first servo motor 205. A first drive rod 203 is connected below the rotating bottle base 201. The first drive rod 203 is connected to a first drive wheel 204. The drive wheel is connected to the first servo motor 205. The first servo motor 205 can drive the first drive wheel 204 to rotate, causing the turntable 202 to move towards the drawing assembly 10. After the drawing is completed, it leaves the drawing assembly and returns to its original position. In this embodiment, when the ampoule needs to be drawn into threads, the rotating base 201 moves towards the thread drawing assembly 10 under the rotation of the first drive wheel 204. The thread drawing clamp 1003 of the thread drawing assembly 10 then descends to the neck of the ampoule for thread drawing. At this time, the turntable 202 rotates the ampoule body 360 degrees by the drive of the rotating shaft, so that it is heated evenly and the thread drawing stability is higher.

[0073] like Figure 4 As shown, further, the second drive wheel 904 is provided with a first drive swing arm 906 and a second drive swing arm 907. One side of the first drive swing arm 906 and the second drive swing arm 907 are hinged to each other, and the other side of the first drive swing arm 906 and the second drive swing arm 907 are connected to the second drive wheel 904. The lower part of the first drive rod 203 is connected to the first drive swing arm 906. In this embodiment, the second drive wheel 904 drives the first drive swing arm 906 and the second drive swing arm 907 to swing back and forth, thereby driving the first drive rod 203 to move up and down, so as to realize the raising or lowering of the fire frame assembly 9.

[0074] Furthermore, the flame holder assembly 9 includes a nozzle holder 901, with a nozzle orifice 902 disposed on its upper side. A second drive rod 903 is connected to the lower side of the nozzle holder 901, and a second drive wheel 904 is connected to the second drive rod 903. The second drive wheel 904 rotates to drive the second drive rod 903 to move up and down. A second servo motor 905 is connected to the second drive wheel 904. The bottle rotating assembly 20 is disposed on one side of the nozzle orifice 902 of the flame holder assembly 9. The second drive motor drives the nozzle holder 901 to move downward, and the nozzle orifice 902 can be aligned with the neck of the ampoule disposed on the turntable 202. In this example, the nozzle holder 901 uses two types of nozzle orifices 902 with different power levels. The front nozzle orifice 902 is used for preheating, and the rear nozzle orifice 902 is used for high-temperature melting. This arrangement can improve the efficiency of the wire drawing assembly 10.

[0075] like Figure 8 , 9 As shown, the wire drawing assembly 10 further includes a wire drawing frame 1001, which is equipped with a rotating assembly 1002. A wire drawing clamp 1003 is mounted on the rotating assembly 1002. A third drive rod 1004 is connected to the lower side of the wire drawing frame 1001. A third drive wheel 1005 is connected to the third drive rod 1004. The third drive wheel 1005 rotates to drive the third drive rod 1004 up and down. A third servo motor 1006 is connected to the third drive wheel 1005. The third servo motor 1006 drives the wire drawing frame 1001 to move up and down. In this embodiment, the wire drawing clamp 1003, from its open state, descends to the neck of the ampoule and clamps it. Then, the molten neck is lifted upwards. The angle of the wire drawing clamp 1003 is changed by the third rotating rod, causing it to turn towards the slag discharge device. After the wire drawing clamp 1003 opens, the bottle residue is discharged. The rotating bottle assembly 20 rotates the ampoule body 360 degrees through equidistant rotating shaft platforms, so that the neck of the ampoule can be heated evenly.

[0076] like Figure 7As shown, further, a sealing housing 21 is provided after the wire drawing frame 1001. The sealing housing 21 includes a first sealing container 211 and a second sealing container 212 fixedly connected vertically. The upper section of the third drive rod 1004 is disposed in the first sealing container 211, and the lower section of the third drive rod 1004 is disposed in the second sealing container 212. A first through hole 213 is provided at the junction of the first sealing container 211 and the second sealing container 212 for the third drive rod 1004 to pass through. The upper section of the third drive rod 1004 is fitted with a spring, the diameter of which and the cross-sectional area of ​​the upper end of the third drive rod 1004 are larger than the diameter of the through hole; this ensures that the third drive rod 1004 can abut against the spring after being pulled down by force, and the spring can abut against the first through hole 213; the lower edge of the sealing housing 21 abuts against the top of the working platform 18; and a second through hole is provided on the lower edge for the third drive rod 1004 to pass through, and a sealing O-ring 216 is provided on the second through hole. In this embodiment, since the drive device that drives the wire drawing clamp 1003 to swing and open / close is located below the working platform 18, the middle drive rod passes through the working platform 18 to connect the clamp and the drive device, and requires a certain amount of space. This results in a large opening being needed at the working platform 18 for the drive rod to pass through. In traditional ampoule wire drawing processes, it is not necessary to isolate the space of the wire drawing part. In short, the cleanliness requirement for ampoule wire drawing is not high. However, this system also needs to be compatible with the working cleanliness requirements of vials (the aseptic core area is Grade A in a Grade B environment). A large opening in this area cannot meet the cleanliness requirements. This application adds a sealed outer shell to the drive rod and uses a sealing O-ring 216 at the boundary of the isolation space to further seal and isolate the operating part of the wire drawing assembly 10 to achieve a higher cleanliness requirement.

[0077] Furthermore, the rotating assembly 1002 also includes a main support 10021, and a first rotating shaft 10022, a second rotating shaft 10023, and a third rotating shaft 10024 rotatably connected to the main support 10021. The first rotating shaft 10022 and the second rotating shaft 10023 are arranged side by side below the third rotating shaft 10024. The wire drawing clamp 1003 consists of several single-sided components respectively arranged facing each other on the first rotating shaft 10022 and the second rotating shaft 10023. The same side of the first rotating shaft 10022 and the second rotating shaft 10023 are respectively rotatably connected to the main support 10021 through mutually meshing first gears 10025. The wire drawing clamp 1003 is opened or closed by rotating the first rotating shaft 10022 and the second rotating shaft 10023. A wire clamp 1003; the third rotating shaft 10024 allows the rotating assembly 1002 to be flipped to one side; the end of the main support 10021 near the first gear 10025 has an embedded damping structure; the end of the first rotating shaft 10022 near the first gear 10025 is wound with one side of the first steel strand 217, and the other side of the first steel strand is wound around the top of the third drive rod 1004; the end of the third rotating shaft 10024 is wound with one side of the second steel strand 218, which is the first gear side of the first rotating shaft 10022; the other side of the second steel strand 218 is wound around the top of the third drive rod 1004; a third steel strand 219 and a fourth steel strand 220 are connected between the bottom of the third drive rod 1004 and the third drive wheel 1005. In this embodiment, the drawing assembly 10 needs to complete three actions. First, it can move vertically up and down, descending from the initial position to the bottle position. Second, it needs to open and close the clamps so that they can hold the molten bottle neck. Finally, the entire clamping assembly swings outward and opens the clamps, throwing the held residual glass into the slag discharge assembly 23, and returns to the initial position, repeating the above actions. The first rotating shaft 10022 and the second rotating shaft 10023 are used to drive the clamps to open or close. The meshing first gear structure can make the movement of the two rotating shafts highly synchronized, making the opening or closing of the clamps smoother and less prone to jamming or other malfunctions. The third rotating shaft 10024 is located above the first rotating shaft 10022 and the second rotating shaft 10023 and is used to drive the entire clamping device to swing outward. Therefore, its diameter is larger than that of the first rotating shaft 10022 and the second rotating shaft 10023, which can better drive the entire clamping device to swing.

[0078] Further, the third drive wheel 1005, facing the third servo motor 1006, sequentially includes a clamping cam 10051, a swing frame cam 10052, and an opening cam 10053; the clamping cam 10051 drives the wire drawing frame 1001 to move up and down; the swing frame cam 10052, connected to the fourth steel strand, drives the clamp to swing back and forth; the opening cam 10053, connected to the third steel strand 219, drives the wire drawing clamp 1003 to open or close; the third drive rod 1004 includes a left drive rod 10041 and a right drive rod 10042, the upper side of the left drive rod 10041 is connected to the first steel strand, and the lower side is connected to the third steel strand 219, the upper side of the right drive rod 10042 is connected to the second steel strand, and the lower side is connected to the fourth steel strand 220. In this embodiment, steel strands are connected to the upper and lower sides of the drive rod, respectively, and the clamping device and the drive device are linked through the steel strands. Due to its high flexibility and high hardness, it can be better designed in space, saving space while ensuring the stress requirements of the drive wire drawing assembly 10.

[0079] Furthermore, as mentioned above, the first rotating shaft 10022, the second rotating shaft 10023, and the third rotating shaft 10024 have different modes of motion, so the drive wheels and drive rods they are connected to are also different. The first steel strand 217, the third rigid strand 219, the left drive rod 10041, the first rotating shaft 10022, the second rotating shaft 10023, and the clamping cam 10053 form a set of linked components; the second steel strand 218, the fourth steel strand 220, the right drive rod 10042, the third rotating shaft 10024, and the swing frame cam 10052 form a set of linked components; the wire drawing frame 1001 and the clamping cam 10051 form a set of linked components to complete the up and down movement of the upper and lower wire drawing frame 1001.

[0080] Furthermore, an "L"-shaped guide plate 221 and guide wheels 222 disposed between the guide plates 221 are provided in the direction of the steel strand leading to the drive wheel. One side of the guide plate 221 is connected to the lower side of the sealing housing 21, and the other side is connected to the third drive wheel 1005. The third steel strand 219 and the fourth steel strand 220 bypass the guide wheels 222 and connect to the third drive wheel 1005. This arrangement can smoothly change the direction of force and better transmit driving force.

[0081] Furthermore, a shrinkage rod assembly 223 is provided between the clamping cam 10051 and the wire drawing frame 1001. The shrinkage rod assembly 223 includes a shrinkage housing 224 and a displacement rod 225 that can move up and down within the shrinkage housing 224. A support platform 226 is provided at the upper end of the displacement rod 225. The rod body of the displacement rod 225 relies on the clamping cam 10051. By utilizing the self-rotation of the clamping cam 10051, the displacement rod 225 is driven to move up or down. This achieves three different motion actions through a set of drive wheels using three different cams, completing wire drawing and slag discharge. It is multi-functional, non-interfering, highly efficient, and stable.

[0082] like Figure 10 , 11As shown, further, a slag discharge assembly 23 is provided opposite the fire frame assembly 9; the slag discharge assembly 23 includes a ground slag discharge channel 231 with an opening at the top, and a sealed chamber 232 is connected below the ground slag discharge channel 231. The sealed chamber 232 is provided with a movable base plate 233, and the default state of the movable base plate 233 is tilted open; a base plate drive rod 234 is provided on one side of the movable base plate 233, and the base plate drive rod 234 passes through the side wall of the sealed chamber 232 and is connected to a drive cylinder 235. The drive cylinder 235 is fixedly connected to a limiting plate 236; a vertical limiting plate 236 is welded above the sealed slag box 238; a second slag discharge channel 237 is provided below the movable base plate 233, and the outlet of the second slag discharge channel 237 is provided with A sealed slag box 238 is provided. The top of the slag box has an opening that communicates with the outlet of the second slag discharge channel 237 and is sealed to the second slag discharge channel 237. The bottom of the slag box is laid with a track 239, and a slag trolley 240 with rollers is provided on the track 239. The slag trolley 240 is used to receive the residue falling from the second slag discharge channel 237. A sealed front door 241 is provided on the front side of the slag box. The sealed front door 241 is paired with a sensor 242. In this embodiment, an optical fiber sensor 242 is used. When the sensor 242 senses that the sealed front door 241 is open, it notifies the control system to drive the cylinder 235 to close the movable bottom plate 233. When the sensor 242 senses that the sealed front door 241 is closed, it restores the movable bottom plate 233 to its initial open state. In this embodiment, to ensure the cleanliness requirements of the isolation area, the slag discharge system for ampoules also needs to be improved to enhance cleanliness, so that it can meet the cleanliness requirements of the vials passing through this area in the integrated system. Although this working area does not operate when the vials pass through, if the slag discharge system is in an open state, it will reduce the entry of dust or residue into the isolation working area, thereby reducing the cleanliness of the isolation working area. Therefore, this embodiment proposes a slag discharge system that is in an isolated and sealed state regardless of whether it is operating or not. First, when the system is operating, the movable bottom plate 233 of the sealing chamber 232 is open to allow the calcined residue to be discharged; when it is necessary to empty the residue in the slag cart 240, the front door of the slag box is opened, and the movable bottom plate 233 is closed by a sensor, always keeping the isolation space in a sealed state to meet the cleanliness requirements of the vials.

[0083] like Figure 12 , 13As shown, the slag discharge assembly 23 is further provided with an exhaust assembly 25, which includes a fan hopper 251, a pneumatic butterfly valve 252, and a heat exhaust channel 255 connected sequentially from bottom to top; a heat exhaust fan 253 and a fan housing 254 disposed outside the heat exhaust fan 253 are disposed on one side of the start butterfly valve. In this embodiment, the exhaust assembly 25 on the slag discharge assembly 23 can quickly and efficiently dissipate the heat generated when the fire rack assembly 9 heats the ampoules, and the heat exhaust fan 253 absorbs the heat, effectively ensuring that the temperature inside the isolator is within a reasonable range and will not affect the operation of the filling system and the product.

[0084] Furthermore, the air hopper 251 adopts a funnel-shaped structure with its outlet facing the heat exchanger assembly 9. The air hopper 251 concentrates the airflow and increases its velocity, causing the incoming airflow to rotate and pass through the built-in fan ball into the heat exhaust channel 255, thereby achieving automatic air intake. The valve body of the pneumatic butterfly valve 252 is constructed as a short-distance clamp-type structure to accommodate the narrow pipe space, improving the sealing performance of the exhaust assembly 25 and further enhancing the sealing performance of the ampoule-related process equipment to achieve higher cleanliness requirements.

[0085] After the user inputs the bottle type, the sealing process differs between ampoules and vials. The aforementioned flame holder assembly 9, bottle rotating assembly 20, and wire drawing assembly 10 are only activated during ampoule filling. The system activates the bottle rotating motor to ensure uniform 360° heating of the bottle during flame heating. The control system uses electrical signals to control the sealing lifting motor and the wire drawing clamp 1003 motor to perform the corresponding actions to seal the ampoule. When the bottle type is a vial, the above steps are disabled. After filling, the vials need to be capped. After capping, the control system uses signals collected by sensor 242 to determine the capping status and whether the vials need to be discarded.

[0086] The function of the rubber stopper feeding system component 12 is as follows: when filling vials, the rubber stopper feeding system component 12 is activated by the instruction given by the filling program issued by the control system, and the rubber stopper is activated by oscillation to stopper the filled vials; when filling ampoules, the rubber stopper feeding system component 12 is not activated.

[0087] The function of the stopper assembly 13 is as follows: when filling vials, the stopper assembly 13 uses vacuum suction to lift the vial by the lifting block on the lifting rod to press the stopper into the vial, according to the instructions given by the filling program issued by the control system; when filling ampoules, the stopper assembly 13 does not operate.

[0088] The function of the sampling and rejection component 14 is to control the rotation of the star wheel with vacuum suction cup through the command issued by the control system, to sample and reject defective products and samples, and put them into the sampling and rejection box for subsequent material transfer.

[0089] The function of the discharge screw assembly 15 is to arrange the filled penicillin / ampoules at equal intervals and convey them at a uniform speed to the ampoule discharge / penicillin discharge assembly through the discharge screw.

[0090] The functions of the ampoule dispensing assembly 16 and the vial dispensing assembly 17 are as follows: after filling, the filled ampoules are directly discharged from the ampoule dispensing assembly 16 through the action of the dispensing star wheel; the filled vials are conveyed downstream through the vial dispensing assembly 17 and the mesh belt for capping (water injection) or freeze-drying and capping (powder injection).

[0091] Furthermore, a filling control method for an integrated ampoule and vial: This control method is based on any of the aforementioned integrated ampoule and vial filling systems. When the container to be filled is an ampoule, the ampoule filling mode is activated through the control system. The screw component of the feed screw assembly 2, the gear component of the feed star wheel assembly 3, the guardrail component of the bottle protection assembly 6, the gear component of the inlet star wheel 4, and the gear component of the outlet star wheel assembly 11 are replaced to suit the operation of the ampoule. In the ampoule filling mode, the control system controls the feed conveyor belt assembly 1, the feed screw assembly 2, the feed star wheel assembly 3, the inlet star wheel 4, the filling system assembly 7, the needle holder assembly 8, the flame holder assembly 9, the wire drawing assembly 10, and the outlet star wheel assembly. 11. The discharge screw assembly 15 and ampoule discharge assembly operate; when the container to be filled is a vial, the vial filling mode is opened through the control system, and the screw of the feed screw assembly 2, the gear of the feed star wheel assembly 3, the guardrail of the bottle protection assembly 6, the gear of the inlet star wheel 4, and the gear of the outlet star wheel assembly 11 are replaced to suit the operation of the vial; in the ampoule filling mode, the control system controls the operation of the feed mesh belt assembly 1, feed screw assembly 2, feed star wheel assembly 3, inlet star wheel 4, filling system assembly 7, needle holder assembly 8, outlet star wheel assembly 11, rubber stopper feeding system assembly 12, stopper assembly 13, discharge screw assembly 15, and vial discharge assembly 17.

[0092] The feeding conveyor belt assembly 1 transports the containers to the feeding screw assembly 2. The feeding screw assembly 2 changes the transport direction of the containers, transporting them one by one to the feeding star wheel assembly. The feeding star wheel assembly 3, through rotation, transports the containers to the inlet star wheel 4. The inlet star wheel 4 transports the containers to the filling system assembly 7 and the needle holder assembly 8 for nitrogen filling and medication filling. The bottle delivery assembly 5 and the bottle protection assembly 6 hold the containers in the groove of the bottle delivery assembly 5 and protect them with the guardrail of the bottle protection assembly 6, transporting the containers to the relevant process components for processing. Finally, the discharge screw assembly 15 transports the containers to the corresponding outlet.

[0093] The fire rack assembly 9 heats the neck of the ampoule to melt it, and the wire drawing assembly 10 throws the residue from the ampoule to the slag discharge assembly 23.

[0094] The stopper feeding system component 12 is used to store the stopper cap. The stopper cap is rotated inside the container and then fed to the upper part of the stoppering component 13. When the vial is fed to the lower part of the stoppering component 13, the stoppering component 13 presses down as a whole to seal the stopper cap at the upper end of the vial.

[0095] The ampoule or vial filling process and the equipment involved are similar to the existing ampoule or vial independent filling process and the equipment involved. Therefore, the specific details of the equipment will not be elaborated on.

[0096] It should be understood that the present invention is not limited to the precise structure described above and shown in the accompanying drawings, and various modifications and changes can be made without departing from its scope.

Claims

1. A filling system integrating ampoules and vials, characterized in that, The system includes, in sequence, a feeding conveyor belt assembly, a feeding screw assembly, a feeding star wheel assembly, an inlet star wheel, a needle holder assembly, an outlet star wheel assembly, a sampling and rejection assembly, a discharge screw assembly, and a control system; a filling system assembly is located adjacent to the needle holder assembly; a bottle feeding assembly and a bottle protection assembly are located adjacent to the inlet star wheel; a flame holder assembly and a stringing assembly are located between the needle holder assembly and the outlet star wheel assembly; a stopper feeding system assembly and a stopper pressing assembly are located adjacent to the outlet star wheel assembly; and an ampoule discharge assembly and a vial discharge assembly are located at the outlet end of the discharge screw assembly. The control system is connected to the feeding conveyor belt assembly, feeding screw assembly, filling system assembly, needle holder assembly, flame holder assembly, drawing assembly, rubber stopper feeding system assembly, stopper pressing assembly, and discharge screw assembly. A rotating bottle assembly is also provided between the flame holder assembly and the drawing assembly. The rotating bottle assembly includes a rotating bottle base and a turntable with a rotating shaft passing through it. An opening for the turntable to extend from the rotating bottle base is provided. The rotating shaft is connected to a first servo motor. A first drive rod is connected below the rotating bottle base, and the first drive rod is connected to a first drive wheel. The first drive wheel is connected to a first servo motor, which drives the first drive wheel to rotate, causing the turntable to move towards the drawing assembly. After drawing, the wheel moves away from the drawing assembly and returns to its original position. The flame frame assembly includes a nozzle frame with a nozzle orifice on its upper side. A second drive rod is connected to the lower side of the nozzle frame, and a second drive wheel is connected to the second drive rod. The rotation of the second drive wheel drives the second drive rod to move up and down. The second drive wheel is connected to a second servo motor. The bottle rotating assembly is located on one side of the nozzle orifice of the flame frame assembly. The second servo motor drives the nozzle frame to move downward, aligning the nozzle orifice with the neck of the ampoule on the turntable. The drawing assembly includes a drawing frame with a rotating assembly and drawing clamps. A third drive rod is connected to the lower side of the drawing frame, and a third drive wheel is connected to the third drive rod. The rotation of the third drive wheel drives the third drive rod to move up and down. The third drive wheel is connected to a third servo motor, which drives the drawing frame to move up and down.

2. The ampoule-vial integrated filling system according to claim 1, characterized in that, It includes a working platform and an isolation wall surrounding the working platform. The isolation wall, the working platform, and the ceiling form an isolation space. The operating parts of each component in the filling system are located on the working platform, and the drive and power supply parts are located below the working platform.

3. The ampoule-vial integrated filling system according to claim 1, characterized in that, The feeding conveyor belt assembly stores container bottles, and the feeding conveyor belt assembly reduces the distance between two adjacent container bottles until the bottle body is next to the bottle body. At the same time, the feeding conveyor belt assembly transports the container bottles input from the upstream process to the feeding star wheel assembly.

4. The ampoule-vial integrated filling system according to claim 3, characterized in that, The feeding conveyor belt assembly includes a first guardrail, a second guardrail, a feeding conveyor belt, and an arc-shaped tensioning spring. The first guardrail, the second guardrail, and the feeding screw assembly form a "U" shape, with their openings facing the upstream feed inlet. A transport conveyor belt is also laid flat inside the first guardrail, the second guardrail, and the feeding screw assembly, with its transport direction parallel to the axial direction of the feeding screw. The arc-shaped tensioning spring is vertically arranged on the feeding conveyor belt, with one side connected to the first guardrail and the other side connected to the second guardrail.

5. The ampoule-vial integrated filling system according to claim 1, characterized in that, The needle holder assembly is equipped with a servo motor and a transmission screw for moving up and down in coordination with the filling system assembly to perform nitrogen filling and filling operations on the packaging material.

6. The ampoule-vial integrated filling system according to claim 1, characterized in that, The filling system components are connected to the fire frame assembly and the wire drawing assembly via a control system.

7. The ampoule-vial integrated filling system according to claim 1, characterized in that, The second drive wheel is provided with a first drive swing arm and a second drive swing arm. One side of the first drive swing arm and the second drive swing arm are hinged to each other, and the other side of the first drive swing arm and the second drive swing arm are connected to the adjacent side of the second drive wheel. The lower part of the second drive rod is connected to the first drive swing arm.

8. The ampoule-vial integrated filling system according to claim 1, characterized in that, A sealing housing is provided behind the wire drawing frame. The sealing housing includes a first sealing container and a second sealing container fixedly connected vertically. The upper section of the third drive rod is disposed in the first sealing container, and the lower end of the third drive rod is disposed in the second sealing container. A first through hole for the third drive rod to pass through is provided at the junction of the first sealing container and the second sealing container. A spring is sleeved on the upper section of the third drive rod. The diameter of the spring and the area of ​​the upper end of the third drive rod are both larger than the diameter of the through hole. This ensures that when the third drive rod is pulled down by force, the third drive rod abuts against the spring, and the spring abuts against the first through hole. The lower edge of the sealing housing abuts against the top of the work platform. A second through hole for the third drive rod to pass through is provided on the lower edge, and a sealing O-ring is provided at the junction of the sealing housing and the second through hole.

9. The ampoule-vial integrated filling system according to claim 8, characterized in that, The rotating assembly further includes a main support frame, and a first rotating shaft, a second rotating shaft, and a third rotating shaft rotatably connected within the main support frame. The first rotating shaft and the second rotating shaft are arranged side by side below the third rotating shaft. The wire drawing clamp consists of several single-sided components respectively arranged facing each other on the first rotating shaft and the second rotating shaft. The same side of the first rotating shaft and the second rotating shaft are rotatably connected to the main support frame via meshing first gears. Rotating the first rotating shaft and the second rotating shaft opens or closes the wire drawing clamp. The third rotating shaft allows the rotating assembly to flip to one side. A damping structure is embedded in the end of the main support frame near the first gear. The first gear end of the first rotating shaft is wound around one side of the first steel strand, and the other side of the first steel strand is wound around the top of the third drive rod. The end of the third rotating shaft is wound around one side of the second steel strand, and the other side of the second steel strand is wound around the top of the third drive rod. A third steel strand and a fourth steel strand are connected between the bottom of the third drive rod and the third drive wheel.

10. The ampoule-vial integrated filling system according to claim 9, characterized in that, The third drive wheel, facing the third servo motor, includes a clamping cam, a swing frame cam, and an opening cam. The clamping cam drives the wire drawing frame to move up and down. The swing frame cam, connected to the fourth steel strand, drives the clamp to swing back and forth. The opening cam, connected to the third steel strand, drives the wire drawing clamp to open or close. The third drive rod includes a left drive rod and a right drive rod. The upper side of the left drive rod is connected to the first steel strand, and the lower side is connected to the third steel strand. The upper side of the right drive rod is connected to the second steel strand, and the lower side is connected to the fourth steel strand.

11. The ampoule-vial integrated filling system according to claim 10, characterized in that, An "L"-shaped guide plate and a guide wheel are provided in the direction of the steel strand leading to the drive wheel. One side of the guide plate is connected to the lower side of the sealing housing, and the other side is connected to the third drive wheel. The third steel strand and the fourth steel strand bypass the guide wheel and are connected to the third drive wheel.

12. The ampoule-vial integrated filling system according to claim 11, characterized in that, A shrink rod assembly is also provided between the clamping cam and the wire drawing frame. The shrink rod assembly includes a shrinking shell and a displacement rod that can move up and down inside the shrinking shell. A support platform is provided at the upper end of the displacement rod. The rod body of the displacement rod relies on the clamping cam. By utilizing the self-rotation of the clamping cam, the displacement rod is driven to move up or down.

13. The ampoule-vial integrated filling system according to claim 12, characterized in that, Opposite the fire frame assembly is a slag discharge assembly. The slag discharge assembly includes a first slag discharge channel with an opening at the top. A sealed chamber is connected below the first slag discharge channel. The sealed chamber has a movable base plate. A base plate drive rod is provided on one side of the movable base plate. The base plate drive rod passes through the side wall of the sealed chamber and is connected to an external drive cylinder. The drive cylinder is fixedly connected to a limiting plate. A second slag discharge channel is provided below the movable base plate. A sealed slag box is provided at the outlet of the second slag discharge channel. An opening communicating with the outlet of the second slag discharge channel is provided above the slag box and is sealed to the second slag discharge channel. A track is laid at the bottom of the slag box. A slag trolley with rollers is provided on the track. The slag trolley is used to receive the residue falling from the second slag discharge channel. A sealed front door is provided on the front side of the slag box. A sensor is paired with the sealed front door. When the sensor senses that the sealed front door is open, it notifies the control system to drive the cylinder to close the movable base plate. When the sensor senses that the sealed front door is closed, it restores the movable base plate to its initial open state.

14. The ampoule-vial integrated filling system according to claim 13, characterized in that, The slag discharge assembly is equipped with an exhaust assembly, which includes a fan hopper, a pneumatic butterfly valve and a heat exhaust channel connected sequentially from bottom to top; a heat exhaust fan and a fan housing disposed outside the heat exhaust fan are disposed together on one side of the heat exhaust channel.

15. The ampoule-vial integrated filling system according to claim 1, characterized in that, The filling system components are connected to the stopper feeding system components and the stopper pressing components via a control system.

16. The ampoule-vial integrated filling system according to claim 1, characterized in that, The filling system components are connected to the discharge screw assembly via a control system; the discharge screw assembly is connected to either the ampoule discharge assembly or the vial discharge assembly.

17. A filling control method for an integrated ampoule and vial: This control method is based on any one of the integrated ampoule and vial filling systems according to claims 1 to 16, characterized in that, When the container to be filled is an ampoule, the ampoule filling mode is activated through the control system. The screw of the feed screw assembly, the gear of the feed star wheel assembly, the guardrail of the bottle protection assembly, the gear of the inlet star wheel, and the gear of the outlet star wheel assembly are replaced to suit the operation of the ampoule. In the ampoule filling mode, the control system controls the operation of the feed conveyor belt assembly, feed screw assembly, feed star wheel assembly, inlet star wheel, filling system assembly, needle holder assembly, flame holder assembly, wire drawing assembly, outlet star wheel assembly, discharge screw assembly, and ampoule discharge assembly. When the container to be filled is a vial, the vial filling mode is activated through the control system. The screw of the feed screw assembly, the gear of the feed star wheel assembly, the guardrail of the bottle guard assembly, the gear of the inlet star wheel, and the gear of the outlet star wheel assembly are replaced to suit the operation of the vial. In the ampoule filling mode, the control system controls the operation of the feed conveyor belt assembly, feed screw assembly, feed star wheel assembly, inlet star wheel, filling system assembly, needle holder assembly, outlet star wheel assembly, rubber stopper feeding system assembly, stopper pressing assembly, discharge screw assembly, and vial discharge assembly. The feeding conveyor belt assembly transports the containers to the feeding screw assembly. The feeding screw assembly changes the transport direction of the containers, transporting them one by one to the feeding star wheel assembly. The feeding star wheel assembly rotates and transports the containers to the inlet star wheel. The inlet star wheel transports the containers to the filling system assembly and needle holder assembly for nitrogen filling and medication administration. The bottle delivery assembly and bottle protection assembly hold the containers in the grooves of the bottle delivery assembly and protect them with the guardrails of the bottle protection assembly, then transport the containers to the relevant process components for processing. Finally, the discharge screw assembly transports the containers to the corresponding outlet. The fire rack assembly heats the neck of the ampoule to melt it, and the wire drawing assembly throws the residue from the ampoule to the slag discharge assembly. The stopper feeding system assembly is used to store the stopper cap. The stopper cap is rotated inside the container and then fed to the upper part of the stoppering assembly. When the vial is fed to the lower part of the stoppering assembly, the stoppering assembly presses down to seal the stopper cap at the upper end of the vial.

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