Chiral amino acid type deep eutectic solvent, and preparation method and application thereof

By preparing a chiral amino acid-based deep eutectic solvent and using it in conjunction with maltodextrin, the problem of poor chiral separation effect in the prior art was solved, and a more efficient enantiomer separation effect was achieved, expanding the application of amino acid deep eutectic solvents in capillary electrophoresis.

CN118125931BActive Publication Date: 2026-06-09AFFILIATED HOSPITAL OF NANTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
AFFILIATED HOSPITAL OF NANTONG UNIV
Filing Date
2024-01-16
Publication Date
2026-06-09

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Abstract

The application relates to the technical field of pharmacy, in particular to a chiral amino acid type deep eutectic solvent and a preparation method and application thereof. The specific technical scheme is as follows: a preparation method of a chiral amino acid type deep eutectic solvent, wherein amino acid and a hydrogen bond donor are heated and stirred in an oil bath until transparent, and the hydrogen bond donor is L-lactic acid or glycerol. The application synthesizes a new type of DESs based on chiral amino acid, uses the DESs as enantiomer separation additives in CE after characterization, and compared with a single MD system, the proposed AADESs / MD synergistic system can significantly improve the enantiomer separation effect of a model drug.
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