A gas island structure for microfluidic chip

Abstract

The present invention provides a gas island structure for a microfluidic chip, comprising a gas island body and a control valve body. The sidewalls of the gas island body are provided with multiple air inlet pipes. The interior of the gas island body is provided with a first main air channel and a second main air channel, the same number as the air inlet pipes. Each of the air inlet pipes is connected to a corresponding first main air channel for air supply. The upper surface of the gas island body is provided with an air outlet connected to the first main air channel and an air inlet connected to the second main air channel. The lower surface of the gas island body is provided with an air outlet connected to the second main air channel. The control valve body is provided at the air inlet and air outlet. By integrating the first and second main air channels, as well as the corresponding air inlet and air outlet holes, within the gas island body, pressure control of multiple hole positions is integrated into a single structure, reducing the need for external hoses and simplifying system design.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a gas island structure for a microfluidic chip. Background Art

[0002] Microfluidic chip technology plays a crucial role in the development and application of single-cell capture platforms. With their ability to precisely manipulate tiny volumes of fluid, microfluidic chips offer revolutionary solutions for sample preparation, reactions, separations, and detection in fields such as biology, chemistry, and medicine. However, practical applications of microfluidic chips, particularly in single-cell capture platforms requiring precise control of pressure at different well locations, still present several technical challenges and challenges.

[0003] Currently, instruments on the market usually connect each hole of each chip to a hose leading to a solenoid valve to achieve pressure control. Although this method meets the needs of pressure control to a certain extent, it brings many inconveniences. First, this design complicates the installation and testing process of the instrument, because each hole needs to be connected to a hose separately, which greatly increases the difficulty and time cost of operation. Secondly, the numerous hose interfaces not only increase the size and weight of the instrument, but also increase the risk of air leakage in the air path, thereby affecting the accuracy and reliability of the experimental results. Even more seriously, plastic hoses have the problem of aging during long-term use. Summary of the Invention

[0004] Based on this, the purpose of the present invention is to provide a gas island structure for a microfluidic chip, which is used to solve the technical problems mentioned in the above background technology.

[0005] The present invention provides a gas island structure for a microfluidic chip, comprising:

[0006] An air island body, wherein the side wall of the air island body is provided with a plurality of air inlet pipes, the interior of the air island body is provided with a first main air channel and a second main air channel having the same number as the air inlet pipes, each of the air inlet pipes is connected to a corresponding first main air channel for air supply, the upper surface of the air island body is provided with an air outlet connected to the first main air channel, and an air inlet connected to the second main air channel, and the lower surface of the air island body is provided with an air outlet connected to the second main air channel;

[0007] A control valve body is provided at the air inlet and the air outlet. When the control valve body is in a closed state, the air path between the air inlet and the air outlet is blocked, and exhaust from the air outlet is obstructed; when the control valve body is in an open state, the air path between the air inlet and the air outlet is connected, and the air outlet releases gas.

[0008] Furthermore, the microfluidic chip uses an air island structure, wherein the air island body has an adjacent first side wall and a second side wall, a plurality of the air inlet pipes are arranged at intervals on the first side wall, the first main air duct and the second main air duct pass through the second side wall to the interior of the air island body, and a sealing plate is provided on the second side wall to close the openings of the first main air duct and the second main air duct.

[0009] Furthermore, the microfluidic chip uses an air island structure, wherein a plurality of the first main air channels are horizontally spaced apart on the second side wall, and the second main air channels are staggered below the first main air channels.

[0010] Furthermore, the microfluidic chip uses an air island structure, wherein the second side wall is provided with a first sealing groove corresponding to the first main air channel and the second main air channel, and a first sealing ring is provided in the first sealing groove.

[0011] Furthermore, the microfluidic chip uses an air island structure, wherein the lower surface of the air island body is provided with drainage air channels with the same number as the air inlet pipes, and the drainage air channels simultaneously penetrate the first main air channel and the inner cavity of the air inlet pipe along the vertical direction of the air island body, so that the air inlet pipe is connected to the first main air channel through the drainage air channels, and the lower surface of the air island body is provided with a seal for sealing the drainage air channels.

[0012] Furthermore, the microfluidic chip uses an air island structure, wherein the sealing member is a sealing bolt, the inner wall of the opening of the drainage airway is provided with an internal thread, and the sealing bolt thread cooperates with the internal thread, thereby sealing the drainage airway.

[0013] Furthermore, the microfluidic chip uses an air island structure, wherein a plurality of partition grooves are provided on the lower surface of the air island body corresponding to the position of the second main air channel, and the plurality of partition grooves divide the second main air channel into a plurality of independent sub-air channels, and each of the sub-air channels has an air inlet connected to the control valve body, and a plurality of air outlets connected to the outside world.

[0014] Furthermore, the microfluidic chip uses a gas island structure, wherein the sub-gas channel passes through the inner side wall of the break groove, and a sealing baffle for closing the sub-gas channel is provided on the inner side wall of the break groove.

[0015] Furthermore, the microfluidic chip uses an air island structure, wherein a second threaded hole is provided on the bottom surface of the isolating groove, and sealing baffles for closing the sub-air channel are respectively provided on both sides of the second threaded hole, and the adjacent sides of the two sealing baffles are inclined surfaces, and the second threaded hole is used to insert a screw, so that the nut part of the screw squeezes the inclined surfaces of the sealing baffles on both sides, so that the sealing baffles fit tightly with the opening of the sub-air channel.

[0016] Furthermore, the microfluidic chip uses an air island structure, wherein a third sealing groove is provided on the bonding surface of the sealing baffle, and a third sealing ring is provided in the third sealing groove.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. By integrating the first and second main air channels, as well as the corresponding air inlet and outlet holes inside the gas island body, the pressure control of multiple holes is integrated into one structure, reducing the need for external hoses and simplifying system design.

[0019] 2. By reducing the use of external hoses, this design reduces the risk of gas leakage, improves the sealing and reliability of the system, and ensures the accuracy of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a three-dimensional diagram of the gas island structure for the microfluidic chip of the present invention from the first perspective;

[0021] Figure 2 A perspective view of the gas island structure for the microfluidic chip of the present invention from a second viewing angle;

[0022] Figure 3 This is an exploded view of the gas island structure used in the microfluidic chip of the present invention;

[0023] Figure 4 A cross-sectional view of the gas island structure for the microfluidic chip of the present invention;

[0024] Figure 5 Schematic diagram of the specific structure of the gas island body in the present invention;

[0025] Figure 6 It is a side view of the gas island body in the present invention;

[0026] Figure 7 for Figure 6 Schematic diagram of the structure of the lower half cut along the cutting line AA;

[0027] Figure 8 for Figure 6 Schematic diagram of the structure of the upper and lower parts cut along the cutting line BB;

[0028] Figure 9 for Figure 6 A schematic diagram of the structure of the lower half cut along the cutting line CC;

[0029] Figure 10 Schematic diagram of the specific structure of the sealing baffle in the present invention;

[0030] Description of main component symbols:

[0031] 100, gas island body; 200, control valve body; 10, air inlet pipe; 11, air inlet pipe a; 12, air inlet pipe b; 13, air inlet pipe c; 14, air inlet pipe d; 20, first main air channel; 21, first main air channel a; 22, first main air channel b; 23, first main air channel c; 24, first main air channel d; 30, second main air channel; 31, sub-air channel; 41, air outlet; 42, air inlet; 43, air outlet; 101, first side wall; 102, second side wall ; 50. Sealing plate; 51. First threaded hole; 52. First mounting hole; 53. First sealing ring; 60. Drainage airway; 61. Drainage airway a; 62. Drainage airway b; 63. Drainage airway c; 64. Drainage airway d; 601. Second sealing ring; 71. Breaking groove; 72. Sealing baffle; 73. Second threaded hole; 74. Inclined surface; 75. Third sealing ring; 81. Connecting plate; 82. Linear bearing; 91. Second mounting hole; 92. Third threaded hole.

[0032] The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0033] To facilitate understanding of the present invention, the present invention will be described more fully below with reference to the accompanying drawings. The drawings illustrate several embodiments of the present invention. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present invention.

[0034] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only.

[0035] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used in this specification of the present invention are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0036] See also Figures 1 to 5 The gas island structure for the microfluidic chip of the present invention includes a gas island body 100 and a control valve body 200.

[0037] The side wall of the gas island body 100 is provided with a plurality of air inlet pipes 10. The interior of the gas island body 100 is provided with the same number of first main air channels 20 and second main air channels 30 as the air inlet pipes 10. Each of the air inlet pipes 10 is connected to a corresponding first main air channel 20 for air supply. The upper surface of the gas island body 100 is provided with an air outlet 41 connected to the first main air channel 20 and an air inlet 42 connected to the second main air channel 30. The lower surface of the gas island body 100 is provided with an air outlet 43 connected to the second main air channel 30.

[0038] The above-mentioned control valve body 200 is arranged at the air inlet hole 42 and the air outlet hole 41. When the control valve body 200 is in a closed state, the air path between the air inlet hole 42 and the air outlet hole 41 is blocked, and the exhaust of the air outlet 43 is blocked; when the control valve body 200 is in an open state, the air path between the air inlet hole 42 and the air outlet hole 41 is connected, and the air outlet 43 releases gas.

[0039] By integrating the first and second main air channels 20, 30, and the corresponding air inlet and outlet ports 42, 41, within the gas island body 100, pressure control for multiple locations is integrated into a single structure, reducing the need for external hoses and simplifying system design. Furthermore, by eliminating the need for external hoses, this design reduces the risk of air leakage, improves the system's sealing and reliability, and ensures experimental accuracy.

[0040] like Figure 3 As shown, the air island body 100 has an adjacent first side wall 101 and a second side wall 102, and a plurality of the air intake pipes 10 are arranged at intervals on the first side wall 101. The first main air duct 20 and the second main air duct 30 pass through the second side wall 102 to the interior of the air island body 100, and the second side wall 102 is provided with a sealing plate 50 for closing the openings of the first main air duct 20 and the second main air duct 30.

[0041] Specifically, in this embodiment, the gas island body 100 is a rectangular parallelepiped structure, the first main air channel 20 and the second main air channel 30 pass through the gas island body 100 along the length direction thereof, and the inner cavity of the air inlet pipe 10 passes through the gas island body 100 along the width direction thereof, and each air inlet pipe 10 is connected to a corresponding first main air channel 20, and the air inlet pipe 10 is used to connect to the gas source to introduce gas into the first main air channel 20. The first main air channel 20 and the second main air channel 30 are connected by a control valve body 200 to control the on-off of the air paths of the two. When the control valve body 200 is opened, the gas sent into the first main air channel 20 by the air inlet pipe 10 can enter the second main air channel 30 through the control valve body 200, and then be discharged from the air outlet 43 on the lower surface of the gas island body 100 to act on the microfluidic chip. In addition, the number of air inlet pipes 10 is not Figure 1 The specific number of the four groups shown can be adjusted as needed. This embodiment is only an example and not a limitation.

[0042] It should be noted that the gas island structure of the microfluidic chip in this embodiment is applied to the single-cell capture platform. The driving structure provided on the single-cell capture platform drives the gas island body 100 to press the microfluidic chip downward, so that the air outlet 43 on the lower surface of the gas island body 100 is aligned with the air inlet on the microfluidic chip. Then, the control valve body 200 is opened to transmit the airflow to the air outlet 43, so that stable single-cell droplets are formed inside the microfluidic chip.

[0043] like Figure 6 As shown, multiple first main air ducts 20 are horizontally spaced apart on the second sidewall 102, and the second main air ducts 30 are staggered below the first main air ducts 20. This design maximizes the internal space of the air island body 100 while ensuring that the first and second main air ducts 20 and 30 do not interfere with each other, thereby improving the spatial efficiency of the overall structure. Furthermore, the staggered layout of the first and second main air ducts 20 and 30 allows the air outlet holes 41 and air inlet holes 42 to be vertically machined on the upper surface of the air island body 100, directly connecting the corresponding first and second main air ducts 20 and 30, effectively reducing the difficulty of machining air paths within the air island body 100.

[0044] like Figure 3 As shown, the second side wall 102 is provided with a plurality of first threaded holes 51, and the sealing plate 50 is provided with a plurality of first mounting holes 52 corresponding to the first threaded holes 51. During assembly, the sealing plate 50 is placed on the second side wall 102 of the gas island body 100, ensuring that the first mounting holes 52 on the sealing plate 50 are fully aligned with the first threaded holes 51 on the gas island body 100. At this point, screws are inserted one by one through the first mounting holes 52 on the sealing plate 50 and into the first threaded holes 51 on the gas island body 100, completing the installation of the sealing plate 50.

[0045] It should be noted that an airtightness test should be performed after the sealing plate 50 is installed to prevent air leakage in the first main air duct 20 or the second main air duct 30 from affecting the experimental results.

[0046] For further information, see Figure 3 The second sidewall 102 is provided with a first sealing groove corresponding to the first main airway 20 and the second main airway 30. A first sealing ring 53 is disposed within the first sealing groove. When the sealing plate 50 is assembled on the second sidewall 102, it squeezes the first sealing ring 53, thereby forming an effective seal and further enhancing the sealing effect of the sealing plate 50 on the first and second main airways 20 and 30.

[0047] See Figure 2 、 Figure 7 and Figure 8 The lower surface of the air island body 100 is provided with drainage air channels 60, the same number as the intake pipe 10. The drainage air channels 60 simultaneously penetrate the first main air channel 20 and the inner cavity of the intake pipe 10 along the vertical direction of the air island body 100, so that the intake pipe 10 is connected to the first main air channel 20 through the drainage air channels 60. The lower surface of the air island body 100 is provided with a sealing member for sealing the drainage air channels 60.

[0048] For details, see Figure 6 and Figure 7In this embodiment, the number of the air intake pipes 10 is 4, corresponding to the air intake pipe a11, the air intake pipe b12, the air intake pipe c13 and the air intake pipe d14 respectively. The second side wall 102 is provided with the corresponding first main air channel a21, the first main air channel b22, the first main air channel c23 and the first main air channel d24, and the lower surface of the air island body 100 is provided with the corresponding drainage air channel a61, the drainage air channel b62, the drainage air channel c63 and the drainage air channel d64. Since the four first main air passages 20 are arranged at intervals along the width direction of the air island body 100, the inner cavity of the air intake pipe a11 needs to be extended to a position aligned with the first main air passage a21, the inner cavity of the air intake pipe b12 needs to be extended to a position aligned with the first main air passage b22, the inner cavity of the air intake pipe c13 needs to be extended to a position aligned with the first main air passage c23, and the inner cavity of the air intake pipe d14 needs to be extended to a position aligned with the first main air passage d24. The inner cavity lengths of the four air intake pipes 10 gradually increase from left to right. The drainage air passage a61 extends along the vertical direction of the air island body 100. The drainage air duct b62 penetrates the inner cavity of the air intake pipe a11 and the first main air duct a21 at the same time along the vertical direction of the air island body 100, the drainage air duct b63 penetrates the inner cavity of the air intake pipe c13 and the first main air duct c23 at the same time along the vertical direction of the air island body 100, and the drainage air duct d64 penetrates the inner cavity of the air intake pipe d14 and the first main air duct d24 at the same time along the vertical direction of the air island body 100, thereby realizing that each air intake pipe 10 is connected to a corresponding first main air duct 20.

[0049] For further information, see Figure 2 The sealing member is a sealing bolt (not shown). The inner wall of the opening of the drainage airway 60 is provided with an internal thread. The sealing bolt thread mates with the internal thread, thereby sealing the drainage airway 60 and preventing gas leakage. Furthermore, a second sealing groove is provided on the lower surface of the gas island body 100 corresponding to the position of the drainage airway 60. A second sealing ring 601 is provided in the second sealing groove. When the sealing bolt blocks the drainage airway 60, the nut portion of the sealing bolt squeezes the second sealing ring 601, thereby forming an effective seal and further enhancing the sealing effect of the sealing bolt on the drainage airway 60.

[0050] See Figure 2 、 Figure 4 and Figure 9, a plurality of partition grooves 71 are provided on the lower surface of the gas island body 100 at positions corresponding to the second main gas channel 30. The plurality of partition grooves 71 divide the second main gas channel 30 into a plurality of independent sub-gas channels 31. Each sub-gas channel 31 has an air inlet 42 connected to the control valve body 200 and a plurality of air outlets 43 connected to the outside. It can be understood that since the plurality of sub-gas channels 31 are independent of each other and each sub-gas channel 31 is individually controlled by a control valve body 200 for gas entry, during the experiment, the user can adjust the control valve body 200 to allow gas to enter the sub-gas channel 31 at a specific position and to exit the gas at the air outlet 43 at a specific position. Secondly, the gas flow and pressure in different sub-gas channels 31 can also be independently adjusted by the control valve body 200, providing greater flexibility and accuracy for the experiment.

[0051] In addition, it is worth mentioning that the independent control of each sub-airway 31 helps to maintain the stability of the entire system. Even if a problem occurs in a sub-airway 31, it will not affect the normal operation of other sub-airways 31.

[0052] See Figure 9 In this embodiment, each of the sub-air channels 31 has two air outlets 43 connected to the outside world, which can provide air pressure to two microfluidic chips at the same time. Of course, in this embodiment, the number of air outlets 43 is only an example and not a limitation, and can be adjusted according to the actual size of the microfluidic chip.

[0053] For further information, see Figure 2 、 Figure 3 and Figure 9 The sub-airway 31 extends through the inner sidewall of the cutout groove 71, which is provided with a sealing flap 72 that seals the sub-airway 31. This design allows for independent maintenance of a single sub-airway 31 without affecting other sub-airways 31. When maintenance is required on a particular sub-airway 31, only the corresponding sealing flap 72 needs to be removed, without dismantling the entire air island body 100, greatly facilitating subsequent maintenance.

[0054] For details, see Figure 2 、 Figure 3 and Figure 10The bottom surface of the cutout groove 71 is provided with a second threaded hole 73. On either side of the second threaded hole 73 are two sealing flaps 72 that seal the sub-airway 31. The adjacent surfaces of the two sealing flaps 72 are inclined surfaces 74. The second threaded holes 73 are used to insert screws, so that the nut portion of the screw presses against the inclined surfaces 74 of the sealing flaps 72 on both sides, making the sealing flaps 72 fit tightly against the opening of the sub-airway 31. When maintenance is required on the sub-airway 31, the sealing flaps 72 can be easily removed by simply removing the screws. After performing the necessary operations on the sub-airway 31, the screws are re-tightened, and the sealing flaps 72 will once again tightly seal the sub-airway 31, restoring the system's sealing state.

[0055] For further information, see Figure 10 The sealing baffle 72 has a third sealing groove on its contact surface, and a third sealing ring 75 is disposed within the third sealing groove. When the sealing baffle 72 blocks the sub-airway 31, the third sealing ring 75 can form an effective seal, further enhancing the sealing effect of the sealing baffle 72 on the sub-airway 31.

[0056] In this embodiment, the control valve is specifically a solenoid valve, which can achieve fast switching response and accurately control the flow of gas, providing precise control of gas flow in the microfluidic system. The gas island body 100 is made of metal material, which has a longer service life than plastic hoses.

[0057] See Figure 2 The two sides of the gas island body 100 extend outward to form connecting plates 81, and the connecting plates 81 are provided with linear bearings 82. It should be noted that the linear bearings 82 are used to cooperate with the guide rods of the single cell capture platform to enable the gas island body 100 to slide up and down along the catheter.

[0058] See Figure 1 and Figure 5 The control valve body 200 is provided with a plurality of second mounting holes 91, and the upper surface of the gas island body 100 is provided with third threaded holes 92 corresponding to the second mounting holes 91. The second mounting holes 91 are used to insert screws and connect the third threaded holes 92, thereby achieving the fixation of the control valve body 200 on the gas island body 100.

[0059] In summary, the microfluidic chip gas island structure in the above-described embodiment of the present invention integrates the first and second main gas channels 20, 30, and the corresponding inlet and outlet holes 42, 41, within the gas island body 100. This allows for integrated pressure control of multiple locations within a single structure, reducing the need for external hoses and simplifying system design. Furthermore, by eliminating the need for external hoses, this design reduces the risk of gas leakage, improves the system's sealing and reliability, and ensures experimental accuracy.

[0060] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0061] The above-described embodiments merely illustrate several implementations of the present invention, and while their descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the spirit of the present invention, all of which fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A gas island structure for a microfluidic chip, characterized in that: include: An air island body, wherein the side wall of the air island body is provided with a plurality of air inlet pipes, the interior of the air island body is provided with a first main air channel and a second main air channel having the same number as the air inlet pipes, each of the air inlet pipes is connected to a corresponding first main air channel for air supply, the upper surface of the air island body is provided with an air outlet connected to the first main air channel, and an air inlet connected to the second main air channel, and the lower surface of the air island body is provided with an air outlet connected to the second main air channel; a control valve body, the control valve body being arranged at the air inlet and the air outlet, and when the control valve body is in a closed state, the air path between the air inlet and the air outlet is blocked, and exhaust from the air outlet is obstructed; When the control valve body is in an open state, the air path between the air inlet and the air outlet is connected, and the air outlet releases gas; A plurality of partition grooves are provided on the lower surface of the gas island body at positions corresponding to the second main gas channel, and the plurality of partition grooves divide the second main gas channel into a plurality of mutually independent sub-gas channels, each of the sub-gas channels having an air inlet connected to the control valve body and a plurality of air outlets connected to the outside; The sub-air channel passes through the inner side wall of the break groove, and a sealing baffle for closing the sub-air channel is provided on the inner side wall of the break groove.

2. The gas island structure for a microfluidic chip according to claim 1, characterized in that: The air island body has an adjacent first side wall and a second side wall, and a plurality of the air intake pipes are arranged at intervals on the first side wall. The first main air duct and the second main air duct pass through the second side wall to the interior of the air island body, and a sealing plate is provided on the second side wall to close the openings of the first main air duct and the second main air duct.

3. The gas island structure for a microfluidic chip according to claim 2, characterized in that: A plurality of the first main air ducts are horizontally arranged on the second side wall at intervals, and the second main air duct is staggered below the first main air duct. 4 . The gas island structure for a microfluidic chip according to claim 2 , wherein a first sealing groove corresponding to the first main air channel and the second main air channel is provided on the second side wall, and a first sealing ring is provided in the first sealing groove.

5. The gas island structure for a microfluidic chip according to claim 1, characterized in that: The lower surface of the air island body is provided with drainage air ducts with the same number as the air intake pipes. The drainage air ducts penetrate the inner cavities of the first main air duct and the air intake pipe at the same time along the vertical direction of the air island body, so that the air intake pipe is connected to the first main air duct through the drainage air ducts. The lower surface of the air island body is provided with a seal for sealing the drainage air ducts.

6. The gas island structure for a microfluidic chip according to claim 5, characterized in that: The sealing member is a sealing bolt. The inner wall of the opening of the drainage airway is provided with an internal thread. The sealing bolt thread matches the internal thread, thereby sealing the drainage airway.

7. The gas island structure for a microfluidic chip according to claim 1, characterized in that: A second threaded hole is provided on the bottom surface of the isolating groove, and the sealing baffles for closing the sub-air duct are respectively provided on both sides of the second threaded hole. The adjacent sides of the two sealing baffles are inclined surfaces, and the second threaded hole is used to insert the screw, so that the nut part of the screw squeezes the inclined surfaces of the sealing baffles on both sides, so that the sealing baffles fit tightly with the opening of the sub-air duct.

8. The gas island structure for a microfluidic chip according to claim 1, characterized in that: A third sealing groove is provided on the fitting surface of the sealing baffle, and a third sealing ring is provided in the third sealing groove.

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