A traditional Chinese medicine composition for treating fever, cough and expectoration

Abstract

The application discloses a traditional Chinese medicine composition for treating fever, cough and expectoration, which is prepared from the following raw medicinal materials in parts by weight: kelp 5-15 parts, hawthorn 5-10 parts, sea buckthorn 5-10 parts, Rosa roxburghii Tratt 10-20 parts, peppermint 5-15 parts, dried tangerine or orange peel 15-20 parts, agastache 5-15 parts, platycodon 5-20 parts, chaenomeles 15-25 parts, mulberry leaf 5-10 parts, apricot kernel 5-10 parts, perilla 10-20 parts, radix puerariae 10-20 parts, gardenia 10-20 parts, amomum 15-25 parts, raphanus 15-20 parts, radix astragali 5-10 parts, imperata 5-15 parts, chrysanthemum 5-20 parts, fat seaurchin 5-20 parts, dandelion 5-20 parts, reed 5-20 parts, caryopteris 5-15 parts, honeysuckle 15-25 parts. The traditional Chinese medicine composition has the effects of clearing heat and reducing fever, nourishing yin and blood, dispersing wind-heat, dredging water passages, removing dampness and malaria, detoxifying, tonifying healthy qi and expelling pathogenic factors.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating fever, cough and expectoration. BACKGROUND

[0002] Fever, cough and expectoration are common diseases of respiratory tract, which are mostly caused by bacterial and / or viral infection, and are clinically accompanied by various symptoms such as headache, cough and fever, and can be life-threatening in severe cases. At present, antibiotics or antiviral drugs are mostly used in clinical treatment, but drug resistance is easily caused, which is not conducive to the control of the disease, or the liver and kidney are injured or the stomach is injured. With the progress of modern pharmacology in recent years, good progress has been made in the treatment of respiratory diseases by traditional Chinese medicine. According to traditional Chinese medicine, respiratory diseases belong to the category of phlegm-heat obstructing lung syndrome, and are characterized by fever, cough, expectoration, sore throat and the like. The lung is invaded by wind-heat pathogen, and the lung loses the function of clearing and purifying due to heat obstruction. The treatment of respiratory diseases by traditional Chinese medicine is rich and characteristic, and at present mainly focuses on: regulating immunity, preventing infection and resisting virus, and improving clinical symptoms, shortening the course of disease and reducing the toxic and side effects of western medicine, and the curative effect is more remarkable for the remission period of exogenous cough, chronic obstructive pulmonary disease, bronchial asthma and pulmonary heart disease.

[0003] However, the traditional Chinese medicine compound currently used for the treatment of respiratory diseases is mostly cold and cool formula, which cannot be taken for a long time, and lacks nourishment to the spleen and stomach, resulting in the inability to tonify the healthy qi, and thus the body cannot effectively resist external evils, and the treatment effect is not satisfactory. In <Analysis on the application of traditional Chinese medicine tea in the prevention and treatment of pneumonia>, Yu Li et al. provide a traditional Chinese medicine compound, which has the effects of immune regulation and anti-inflammatory, can enhance the body's resistance, and has the effect of resisting external evils, but acupuncture treatment is needed to relieve clinical symptoms, especially fever. It is necessary to provide a traditional Chinese medicine formula which not only has remarkable effect in enhancing the body's resistance, but also has advantages in improving clinical symptoms. SUMMARY

[0004] To solve the above problems, the present application provides a traditional Chinese medicine composition for treating fever, cough and expectoration, which is prepared from the following raw materials by weight:

[0005] Kelp 5-15 parts, hawthorn 5-10 parts, sea buckthorn 5-10 parts, roxburgh rose 10-20 parts, peppermint 5-15 parts, dried tangerine or orange peel 15-20 parts, agastache rugosa 5-15 parts, platycodon 5-20 parts, papaya 15-25 parts, mulberry leaf 5-10 parts, apricot kernel 5-10 parts, perilla 10-20 parts, kudzu root 10-20 parts, gardenia 10-20 parts, cardamom 15-25 parts, raphanus 15-20 parts, radix astragali 5-10 parts, imperata cylindrica 5-15 parts, chrysanthemum 5-20 parts, fat sea urchin 5-20 parts, dandelion 5-20 parts, reed 5-20 parts, caryopteris 5-15 parts, honeysuckle 15-25 parts.

[0006] Further, it is prepared from the following raw medicinal materials by weight:

[0007] Kelp 10 parts, hawthorn 8 parts, sea buckthorn 8 parts, roxburgh 10 parts, peppermint 10 parts, dried tangerine or orange peel 20 parts, agastache 10 parts, platycodon 15 parts, papaya 25 parts, mulberry leaf 7 parts, apricot kernel 8 parts, perilla 11 parts, kudzu root 11 parts, gardenia 15 parts, cardamom 25 parts, raphanus 20 parts, milk vetch 9 parts, lalang 14 parts, chrysanthemum 14 parts, fat sea 6 parts, dandelion 15 parts, reed 14 parts, mugwort 13 parts, honeysuckle 25 parts.

[0008] Further, the lalang is fresh lalang, and the reed is fresh reed.

[0009] Further, it is prepared from the medicinal powder of the raw medicinal materials, or the water or organic solvent extract of the raw medicinal materials as the active ingredient, and the pharmaceutically acceptable adjuvant.

[0010] Further, the preparation is an oral preparation.

[0011] Further, the oral preparation includes granules, solutions, pills, powders, pastes, tablets.

[0012] The application also provides a preparation method of the aforementioned traditional Chinese medicine composition, which comprises the following steps:

[0013] (1) the raw medicinal materials are weighed according to the aforementioned proportion;

[0014] (2) the raw medicinal materials are ground into powder, or the water or organic solvent extract of the raw medicinal materials is obtained, and the commonly used adjuvant or auxiliary ingredient for medicines is added.

[0015] The application finally provides the use of the aforementioned traditional Chinese medicine composition in the preparation of a medicine for treating fever, cough and sputum.

[0016] Further, the medicine is a medicine for relieving fever and reducing fever and / or relieving phlegm and relieving cough.

[0017] Further, the medicine has the effect of expelling evil and supporting the healthy.

[0018] The fresh lalang in the application refers to the lalang that is not processed after being collected.

[0019] The fresh reed in the application refers to the reed that is not processed after being collected.

[0020] This invention utilizes a traditional Chinese medicine composition. Tangerine peel (Chenpi) clears heat and dispels stagnation in the chest and chest, while platycodon root (Jiegeng) treats sore throat, replenishes deficiency, eliminates phlegm, and breaks up masses. Peppermint (Bohe) clears heat and phlegm, benefits the throat and diaphragm, and treats wind-heat. Chrysanthemum (Juhua) clears wind and heat, relieves chest discomfort and heat, and benefits the five meridians. Dandelion (Pugongying) clears heat and detoxifies, eliminates carbuncles and nodules. Mulberry leaf (Sangye) disperses wind-heat, cools and relieves exterior symptoms, clears the lungs and moistens dryness. These six ingredients work together to clear heat and detoxify, promote lung function, and dispel wind and heat, thus harmonizing the body's defenses and relieving irritability. It also clears heat and detoxifies, cools the blood and eliminates toxins for inflammation and heat syndromes caused by accumulated external pathogens in the internal organs.

[0021] Malva nut clears lung heat and soothes the throat; honeysuckle clears wind-heat and dampness from the meridians and relieves febrile diseases; apricot kernel stops cough, eliminates phlegm, and moistens the lungs; and Imperata cylindrica root clears heat, cools the blood, and soothes the throat. The four ingredients work together to relieve sore throat and cough, and detoxify, cool the blood, and relieve fever.

[0022] Gardenia clears heat and promotes diuresis, cools the blood and detoxifies; kelp promotes urination, drains water and removes dampness, breaks up accumulations and softens hard masses; sea buckthorn stops cough and eliminates phlegm, promotes digestion and removes stagnation, invigorates blood and removes blood stasis; prickly pear clears heat and promotes digestion. Together, these four herbs work to clear heat, detoxify and dry dampness, thus promoting urination.

[0023] Elsholtzia ciliata is used to treat seasonal typhoid fever, regulate qi, relieve irritability and fever, and treat nausea and vomiting. Patchouli dispels cold, dampness, summer heat, dampness and heat, and replenishes defensive qi and stomach qi. The combination of the two is aromatic and opens the orifices, relieves headaches and stuffiness, and enhances the body's vital energy.

[0024] Kudzu root releases the exterior and relieves muscle tension, thus expelling pathogenic factors; hawthorn resolves food stagnation, promotes qi circulation, strengthens the stomach and widens the diaphragm, and eliminates blood stasis and qi stagnation; cardamom digests food and water, warms the spleen and stomach, promotes qi circulation, regulates the middle jiao, and resolves stagnation; astragalus tonifies qi and generates fluids, replenishes qi and promotes qi circulation; papaya astringes the lungs and harmonizes the stomach, regulates the spleen and liver, and promotes food circulation and quenches thirst; perilla promotes qi circulation, widens the middle jiao, eliminates phlegm and benefits the lungs; radish seed lowers qi, widens the middle jiao, reduces phlegm, and calms wheezing; imperata root clears heat, generates fluids, relieves irritability, promotes urination, removes stomach heat, and treats vomiting, lung abscess, and purulent sputum. The eight ingredients work together to strengthen the spleen and stomach, resolve dampness, warm the middle jiao and dispel cold, relieve nausea and vomiting, and warm the middle jiao and lower qi to expel pathogenic factors smoothly.

[0025] The formula uses Amomum villosum, Radish seed, Papaya, Tangerine peel, and Honeysuckle as the chief herbs; Peppermint, Patchouli, Platycodon grandiflorus, Apricot kernel, Perilla frutescens, Kudzu root, Gardenia jasminoides, Astragalus membranaceus, Imperata cylindrica root, Dandelion, Phragmites communis root, and Elsholtzia ciliata as the assistant herbs; Laminaria japonica, Hawthorn, Sea buckthorn, and Rosa rugosa as the adjuvant herbs; and Chrysanthemum morifolium, Sterculia lychnophora, and Mulberry leaf as the guiding herbs. Together, they clear heat and detoxify, promote lung qi circulation, dispel wind and heat, cool the blood, and detoxify. This formula is beneficial for calming the mind and relieving irritability, soothing the throat, and while eliminating inflammation and heat caused by accumulated external pathogens in the internal organs, it also focuses on strengthening the spleen and stomach to resolve dampness, warm the middle jiao and dispel cold, and promote the downward flow of qi to expel pathogens. This approach promotes the expulsion of external pathogens and strengthens the spleen and stomach center, enhancing the absorption of the medicine and creating a positive cycle. Simultaneously, regulating qi also helps reduce coughing caused by upward flow of qi.

[0026] Animal experiments show that the traditional Chinese medicine composition has the effects of clearing heat and reducing fever, nourishing yin and blood, and dispersing wind-heat, and has remarkable effects in reducing body temperature when feverish. Meanwhile, the traditional Chinese medicine composition has the effects of dredging water passages, removing dampness and malaria, and obviously removing phlegm and relieving cough. The traditional Chinese medicine composition has advantages in improving clinical symptoms, and has outstanding advantages in enhancing body anti-inflammatory and immune regulation, and can have the effects of detoxification, tonifying healthy qi, and strengthening the body to resist evils.

[0027] Obviously, according to the above content of the present application, according to the ordinary technical knowledge and common means in the art, other various forms of modifications, replacements or changes can be made without departing from the above basic technical idea of the present application.

[0028] The above content of the present application will be further explained in detail through the following embodiment. However, it should not be understood that the above subject matter of the present application is limited to the following examples. Any technology realized based on the above content of the present application belongs to the scope of the present application. DETAILED DESCRIPTION

[0029] The raw materials and equipment used in the embodiment of the present application are known products, which are obtained by purchasing commercially available products. The preparation process of granules, solutions, pills, tablets, powders or pastes made of the composition of the present application is mature, and can be prepared by referring to conventional methods in the prior art.

[0030] Example 1, preparation of the medicine of the present application

[0031] Formula: Kelp 10g, hawthorn 8g, sea buckthorn 8g, roxburgh rose 10g, mint 10g, dried tangerine or orange peel 20g, agastache rugosa 10g, platycodon 15g, papaya 25g, mulberry leaf 7g, apricot kernel 8g, perilla 11g, kudzu root 11g, gardenia 15g, cardamom 25g, radish seed 20g, radix astragali 9g, imperata cylindrical 14g, chrysanthemum 14g, fat seaurchin 6g, dandelion 15g, reed 14g, caryophyllus 13g, honeysuckle 25g.

[0032] Preparation method: the above raw materials are weighed according to the proportion, soaked in 15 times the amount of water for 20 minutes, then decocted for 20-30 minutes, filtered, the dregs are added with 15 times the amount of water, and decocted and filtered again once, the two filtrates are combined and concentrated under reduced pressure to prepare the decoction.

[0033] Example 2, preparation of the medicine of the present application

[0034] Formula: Kelp 5g, hawthorn 5g, sea buckthorn 5g, roxburgh rose 10g, mint 5g, dried tangerine or orange peel 5g, agastache rugosa 5g, platycodon 5g, papaya 5g, mulberry leaf 5g, apricot kernel 5g, perilla 10g, kudzu root 10g, gardenia 10g, cardamom 5g, radish seed 5g, radix astragali 5g, imperata cylindrical 5g, chrysanthemum 5g, fat seaurchin 5g, dandelion 5g, reed 5g, caryophyllus 5g, honeysuckle 5g

[0035] Preparation method: the above-mentioned raw materials are weighed according to the proportion, soaked in 12 times the amount of water for 20 minutes, then decocted for 20-30 minutes, filtered, the residue is added with 12 times the amount of water, repeated decoction and filtration once, the filtrates are combined, the filtrate is concentrated into thick paste under reduced pressure, and then the conventional excipients for medicines are added to prepare tablets.

[0036] Example 3, preparation of the medicine of the present application

[0037] Formula: Kelp 15g, haw 10g, sea buckthorn 10g, rose apple 20g, mint 15g, dried tangerine or orange peel 20g, agastache rugosa 15g, platycodon 20g, papaya 10g, mulberry leaf 10g, apricot kernel 10g, perilla 20g, radix puerariae 20g, gardenia 20g, cardamom 10g, raphanus 20g, radix astragali 10g, imperata cylindrical 15g, chrysanthemum 20g, fat sea 20g, dandelion 20g, reed 20g, caryophyllus 15g, honeysuckle 15g

[0038] Preparation method: the above-mentioned raw materials are weighed according to the proportion, soaked in 10 times the amount of water for 20 minutes, then decocted for 20-30 minutes, filtered, the residue is added with 10 times the amount of water, repeated decoction and filtration once, the filtrates are combined, the filtrate is concentrated into thick paste under reduced pressure, and then the conventional excipients for medicines are added to prepare granules.

[0039] The composition of the present application is an excellent formula formed through a large number of screening, and the curative effect is poor if the medicinal ingredients in the formula are replaced by other medicinal ingredients. The beneficial effects of the present application are further illustrated by listing some comparative groups in the test examples.

[0040] Test example 1: efficacy research based on animal experiments

[0041] In the experiment, 9 or 10 groups were set up for efficacy observation, specifically, in addition to the blank group, the model group, the control group, group 1 (the medicine prepared in example 1), another 6 control groups formed by splitting the formula in example 1, the corresponding split formula and numbers are as follows:

[0042] 2 group: dried tangerine or orange peel 20g, platycodon 15g, mint 10g, chrysanthemum 14g, dandelion 15g, mulberry leaf 7g

[0043] 3 group: fat sea 6g, dried tangerine or orange peel 20g, apricot kernel 8g

[0044] 4 group: gardenia 15g, kelp 10g, sea buckthorn 8g, rose apple 10g

[0045] 5 group: caryophyllus 13g, agastache rugosa 10g, radix astragali 9g

[0046] 6 group: radix puerariae 11g

[0047] Group 7: Hawthorn 8g, Amomum 25g, Tangerine Peel 20g, Chaenomeles 25g, Perilla 11g, Raphanus 20g

[0048] Each group of the control group was prepared according to the preparation method of Example 1 into the same decoction containing the same amount of crude drug.

[0049] I. Heat-clearing and fever-reducing experiment

[0050] 1. Method

[0051] A large number of research results believe that LPS is the active component of gram-negative bacterial endotoxin, has high water solubility, and is a very strong bacterial pyrogen, and the type of fever induced by it is biphasic or triphasic, which is similar to the type of fever caused by clinical infectious inflammation. Therefore, 80 healthy Kunming mice with normal development and no fever lesions were randomly divided into 10 groups (blank group, model group, control group, group 1-7), 8 mice per group, and the body weight of the mice was about 18-22g. Except for the blank group, LPS was used to induce fever in the other groups of mice.

[0052] The mice were fasted for 8 hours before modeling but not deprived of water. The blank group and the model group were given 0.2mL / 10g of normal saline by gavage, and the body temperature was measured every 0.5h for 10h. Except for the blank group, the other groups were given LPS (20μg / kg) by intraperitoneal injection to induce animal fever, and different drugs were given by gavage at the same time; the control group was given acetaminophen at a dose of 1.5mg / 20g; groups 1-7 were given the corresponding Chinese medicine decoction according to the grouping, with a dose of 0.2mL / 10g. After injection of LPS, the body temperature was measured every 0.5h for 10h, and the maximum body temperature rise height △T (the difference between the body temperature during fever and the basal body temperature) was recorded.

[0053] 2. Results

[0054] The specific results are shown in Tables 1-3

[0055] Table 1: △T (℃) data measured every 0.5h

[0056]

[0057]

[0058] Table 2: △T (℃) data measured every 0.5h

[0059]

[0060] Table 3: △T (℃) data measured every 0.5h

[0061]

[0062]

[0063] Note: compared with the blank group, *p≤0.05; compared with the model group, #p≤0.05; compared with #1 group, ☆p≤0.05.

[0064] From the above results, it can be seen that for the LPS-induced fever model mice, the prescription of the application can reduce the temperature within 1.5h and last for 8.5h, and has a definite effect of reducing temperature, antipyretic and fever-reducing, and the effect is fast and strong. After the prescription of the application is split differently, the antipyretic and fever-reducing effect of each split item is not obvious. Therefore, it is illustrated that the prescription of the application has the effects of clearing heat and reducing fever, nourishing yin and blood, and dispersing wind-heat through a specific drug composition.

[0065] II. Phlegm experiment

[0066] 1. Method

[0067] Select 72 healthy Kunming mice with normal development and no fever lesions, weighing about 18-22g, and randomly divide them into 9 groups (blank group, control group, group 1-7), 8 mice in each group, to conduct tracheal phenol red excretion experiment. The experimental principle is that phenol red is used as an indicator. After intraperitoneal injection of phenol red in mice, if the mice take drugs with phlegm-removing effect, the secretion of the mouse bronchus will increase, the excretion of phenol red in the respiratory mucosa will increase, and the excretion of phenol red will increase, indicating that the coughing out of phlegm is promoted. Therefore, the effect of the experimental drug on the excretion of phenol red in the trachea can be used to infer the expectorant effect of the drug.

[0068] The blank group is given normal saline by gavage at 0.2mL / 10g, the control group is given compound fresh bamboo juice, and groups 1-7 are given corresponding traditional Chinese medicine decoction according to the grouping, with a dose of 0.2mL / 10g. Before the experiment, the mice are fasted for 8h, and 30min after the administration, each mouse is intraperitoneally injected with 2.5% phenol red solution 0.7mL, and immediately after 30min, the mice are sacrificed, fixed in a supine position, the trachea is separated, 0.5mL of 5% NaHCO3 solution is extracted with a 1mL syringe, inserted into the trachea about 0.3-0.5cm from the thyroid cartilage, and the trachea is flushed 3 times, with 3 times of back and forth suction each time. The 3 times of washing liquid is combined, centrifuged for 15min, the supernatant is diluted 5 times with distilled water, and the phenol red absorption value (A) is measured at a wavelength of 546nm with a ultraviolet spectrophotometer.

[0069] 2. Results

[0070] The specific results are shown in Table 4

[0071] Table 4 Comparison of tracheal phenol red excretion of mice in each group

[0072]

[0073]

[0074] Note: compared with the blank group, *p≤0.05; compared with #1 group, ☆p≤0.05.

[0075] From the above results, it can be seen that the prescription of the application can promote the secretion of phenol red in the trachea of mice, suggesting that it has obvious expectorant effect and reduces phlegm. After the prescription of the application is split differently, the expectorant effect of each split item is not obvious. Therefore, it is illustrated that the prescription of the application can take into account the function of spleen and stomach transportation by specific drug composition, and has the effects of dredging water passage and removing dampness.

[0076] III. Acute upper respiratory tract infection simulation experiment

[0077] 1. Method

[0078] Acute upper respiratory tract infection belongs to the category of exogenous in traditional Chinese medicine. No matter the exogenous pathogen is wind-cold, wind-heat or exogenous epidemic, the lung qi will be impaired, and the cold in the exterior will be transformed into heat, which will cause the phlegm-heat and lung heat. Traditional Chinese medicine believes that no matter what the exogenous pathogen is, it is because of the internal cause of "deficiency of vital qi". Therefore, it is necessary to support the healthy qi and eliminate the pathogenic factors, so as to improve the immune capacity of the body, inhibit bacteria and anti-inflammatory, and control the disease, reduce the symptoms and shorten the course of disease by mobilizing the body's immunity.

[0079] Eighty healthy Kunming mice with normal development and no fever lesions were selected, with a body weight of about 18-22 g, and were randomly divided into 10 groups (blank group, model group, control group, group 1-7), 8 mice in each group. Except for the blank group, the rest of the mice were slowly dripped with 50 μl of staphylococcus aureus liquid from the nose under the condition of ether anesthesia, and then automatically inhaled. One hour after modeling, drug treatment was started. The blank group and the model group were given 0.2 mL / 10 g of normal saline by gavage, and the control group was given 1.5 mg / 20 g of azithromycin. Groups 1-7 were given corresponding traditional Chinese medicine decoction by gavage according to the grouping, with a dose of 0.2 mL / 10 g. The mice were fasted for 8 hours before the experiment, and were given drugs once a day for 7 consecutive days. Seven days after modeling, TNF-α and IL-6 were detected.

[0080] 2. Results

[0081] The specific results are shown in Tables 5-6.

[0082] Table 5: Lung TNF-α content of mice in each group (pg / ml)

[0083]

[0084] Note: compared with the blank group, *p≤0.05; compared with the model group, #p≤0.05; compared with #1 group, ☆p≤0.05.

[0085] Table 6: Lung IL-6 content of mice in each group (pg / ml)

[0086]

[0087] Note: compared with the blank group, *p≤0.05; compared with the model group, #p≤0.05; compared with the #1 group, ☆p≤0.05.

[0088] TNF-α has inflammation, immunity, internal environment stability and other activities, TNF-α and IL-6 are important links in the immune regulation system of the body after infection, have the effect of improving the immune response of the body, and have an important role in resisting infection. The experimental results show that, compared with the healthy and lively mice in the blank group, the concentration of TNF-α and IL-6 in the model group of mice is increased, and the mental state of the mice is not good, the mice are curled up, the reaction to the surrounding environment is poor, the hair is erect and has no luster, and part of the mice has increased conjunctival secretion, rapid breathing with coughing symptoms, which is positively correlated with the degree of clinical verification of infection fever. Among the mice treated by gavage, it is found that the content of TNF-α and IL-6 in the lung tissue homogenate of the mice in the control group and the 1 group is obviously reduced compared with the model group, and the mental state of the mice is gradually improved, the breathing is stable, and there is no coughing symptom. Compared with other split groups, the 1 group is obviously better than other groups, which shows that the composition of the application can activate the immune mechanism of the body in a short time, enhance the anti-inflammatory and immune regulation effect of the body, shorten the anti-inflammatory process of the body, and accelerate the recovery of respiratory tract infectious diseases, but other formulations after splitting the composition of the application do not have obvious effect.

[0089] From the experimental results, it can be seen that the prescription of the application has the effects of detoxification, tonifying qi and supporting healthy qi and expelling pathogenic factors by specific drug composition, not only has advantages in improving the clinical symptoms of fever, sputum and cough, but also has outstanding advantages in enhancing the anti-inflammatory and immune regulation of the body.

Claims

1. A traditional Chinese medicine composition for treating fever, cough and expectoration, characterized in that: It is prepared from the following raw medicinal materials: ​ Kelp 10 parts, hawthorn 8 parts, sea buckthorn 8 parts, roxburgh 10 parts, mint 10 parts, dried tangerine or orange peel 20 parts, agastache 10 parts, platycodon 15 parts, papaya 25 parts, mulberry leaves 7 parts, apricot kernel 8 parts, perilla 11 parts, kudzu 11 parts, gardenia 15 parts, cardamom 25 parts, raphanus 20 parts, milk vetch 9 parts, white morinda 14 parts, chrysanthemum 14 parts, fat 6 parts, dandelion 15 parts, reed 14 parts, caryopteris 13 parts, honeysuckle 25 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that: The white morinda is fresh white morinda, and the reed is fresh reed.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that: It is a preparation prepared from the medicinal powder of the raw medicinal materials, or the water or organic solvent extract of the raw medicinal materials as the active ingredient, plus pharmaceutically acceptable excipients.

4. The traditional Chinese medicine composition according to claim 3, characterized in that: The preparation is an oral preparation.

5. The traditional Chinese medicine composition according to claim 4, characterized in that: The oral preparation includes granules, solutions, pills, powders, pastes, and tablets.

6. The preparation method of the traditional Chinese medicine composition according to any one of claims 1-5, characterized in that: It includes the following steps: (1) The raw medicinal materials are weighed according to the proportions in claim 1; (2) The raw medicinal materials are ground into powder, or the water or organic solvent extract of the raw medicinal materials is added with commonly used pharmaceutical excipients or auxiliary ingredients, and the mixture is obtained.

7. Use of the traditional Chinese medicine composition of any one of claims 1-6 in the preparation of a medicine for treating fever, cough, and sputum.

8. Use according to claim 7, characterized in that: The medicine is an antipyretic, antiphlogistic, and / or expectorant and antitussive medicine.

9. Use according to claim 7 or 8, characterized in that: The medicine has the effect of expelling pathogenic factors and supporting the healthy qi. The medicine has the effect of expelling pathogenic factors and supporting the healthy qi.

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