A traditional Chinese medicine composition for treating cough caused by cold, and its preparation method and application

Abstract

The present invention provides a traditional Chinese medicine composition for treating cough caused by a cold, and its preparation method and application, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention is composed of cooked aconite root, dried ginger, ginseng, stir-fried white atractylodes macrocephala, roasted licorice root, stir-fried coix seed, poria, bupleurum root, white peony root, immature bitter orange, ephedra, apricot kernel, forsythia suspensa, gypsum, cicada slough, and amethyst. The present invention uses aconite root and dried ginger to warm yang as the main medicine; ginseng and atractylodes macrocephala nourish the middle and replenish qi; bupleurum root and white peony root, one ascending and one astringing, and apricot kernel invigorating qi, which not only soothe the liver and regulate qi to avoid qi stagnation, but also guide warming herbs upward, as the ministerial medicine; coix seed and poria strengthen the spleen and eliminate dampness; ephedra, apricot kernel, gypsum, forsythia suspensa, cicada slough, and amethyst to promote lung function and relieve cough; roasted licorice root relieves urgency, harmonizes the middle, and can also harmonize the other medicines as the guiding medicine; the combination of these medicines achieves the effects of warming yang, regulating qi, promoting lung function and relieving cough. The composition of the present invention is used for treating post-infectious cough and chronic cough of lung and spleen yang deficiency type, with a total effective rate of up to 94.4%, a low recurrence rate and no adverse reactions.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating cough caused by cold, and a preparation method and application thereof. Background Art

[0002] The common cold, also known as the flu, is a common acute upper respiratory viral infection, often caused by rhinoviruses, parainfluenza viruses, respiratory syncytial viruses, echoviruses, coxsackieviruses, coronaviruses, and adenoviruses. Clinical manifestations include nasal congestion, sneezing, runny nose, fever, cough, and headache, which are generally self-limited. They are often sporadic, occurring more frequently in winter and spring, and more frequently during seasonal transitions. When the acute symptoms of a respiratory infection subside, a persistent cough persists for three to eight weeks or even longer, with no obvious abnormalities on chest X-rays. This is called a "post-infectious cough," also known as a "post-cold cough." Long-term observation has revealed that some patients with post-infectious cough exhibit a craving for cold drinks, such as cold water and cold beverages. These coughs, often after a cold or infection, persist for a long time. Physical examination reveals a pale tongue with a thin, slightly greasy white coating and tooth marks along the edges. The pulse is weak, deep, and thready on both hands.

[0003] Currently, Western medicine typically uses antibiotics to treat coughs after a cold, but long-term use can lead to drug resistance. Traditional Chinese medicines available on the market, such as Qingfei Oral Liquid, Qingxuan Zhike Lu, and Xiaoji Zhike Oral Liquid, are slow to cure and have a high recurrence rate. Therefore, there is an urgent need to develop a traditional Chinese medicine with a low recurrence rate and good therapeutic effect to treat the common symptoms of coughs after a cold. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating cough caused by cold, and its preparation method and application. The traditional Chinese medicine composition of the present invention has a low recurrence rate, no adverse reactions, and good clinical effects.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating cough caused by cold. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 3-9 parts of cooked aconite root, 13-18 parts of dried ginger, 8-12 parts of ginseng, 18-23 parts of stir-fried white atractylodes, 8-12 parts of roasted liquorice root, 25-35 parts of stir-fried coix seeds, 18-23 parts of poria, 8-12 parts of bupleurum root, 8-12 parts of white peony root, 8-12 parts of immature bitter orange, 3-9 parts of ephedra, 8-12 parts of apricot kernel, 8-12 parts of forsythia, 13-18 parts of gypsum, 3-9 parts of cicada slough and 25-35 parts of amethyst.

[0007] Preferably, it is composed of the following raw materials in parts by weight: 6 parts of cooked aconite, 15 parts of dried ginger, 10 parts of ginseng, 20 parts of stir-fried white atractylodes, 10 parts of roasted licorice, 30 parts of stir-fried coix seeds, 20 parts of poria, 10 parts of bupleurum, 10 parts of white peony root, 10 parts of immature bitter orange, 6 parts of ephedra, 10 parts of apricot kernel, 10 parts of forsythia, 15 parts of gypsum, 6 parts of cicada shell and 30 parts of purple quartz.

[0008] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, comprising: mixing cooked aconite root, ginseng, gypsum and purple quartz and decocting them separately, then decocting them together with other raw materials, filtering, decocting the residue again, combining the filtrate, concentrating, standing, filling and sterilizing to obtain the composition.

[0009] Preferably, the material-liquid ratio of the single decoction, the combined decoction and the boiling is 1:6-10 g / mL.

[0010] Preferably, the single frying time is 25 to 35 minutes.

[0011] Preferably, the time for the combined decocting and the boiling is 30 to 35 minutes.

[0012] Preferably, the concentration comprises: concentrating the filtrate to 1.02-1.06 at 50-60°C.

[0013] Preferably, the standing temperature is 2-5°C and the standing time is 24-72 hours.

[0014] The present invention also provides the use of the traditional Chinese medicine composition in preparing medicine for treating post-infectious cough of lung and spleen yang deficiency type.

[0015] Preferably, the dosage form of the medicine is a decoction.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The present invention uses aconite root and dried ginger to warm the yang, which are the main medicine; ginseng and white atractylodes nourish the middle and replenish qi, bupleurum can both relieve liver depression and promote clear yang, peony nourishes blood and restrains yin, and is matched with bupleurum, one ascends and one astringes, and is assisted by bitter orange to disperse qi and disperse stagnation, so as to enhance the effect of dredging qi mechanism, avoid aconite root and dried ginger warming yang too much to transform fire, and simultaneously promote the power of warming yang to reach the lung, improve the disease of lung yang deficiency; ephedra promotes lung function to relieve asthma and cough, apricot root descends lung qi, while gypsum and forsythia assist ephedra in inducing sweating, cicada slough and purple quartz are the opposite medicines, cicada slough dispels wind and heat, amethyst warms the middle and lowers qi, one ascends and one descends, cooperates with ephedra and apricot root, strengthens the power of promoting lung function to relieve cough, and is assisted by solving throat itching, fried coix seed and poria are assisted by invigorating the spleen and removing dampness, and roasted liquorice relieves urgency and harmonizes the middle, and can also coordinate various medicines. All medicines are used together to play the power of warming yang and regulating qi, promoting lung function to relieve cough.

[0018] The present invention uses the above-mentioned composition for treating post-infectious cough and chronic cough of lung and spleen yang deficiency type, and has good clinical efficacy. Clinical experiments have shown that the composition of the present invention has a total efficacy of up to 94.4% in treating post-infectious cough of lung and spleen yang deficiency type, with a low recurrence rate and no adverse reactions. DETAILED DESCRIPTION

[0019] The invention provides a traditional Chinese medicine composition for treating cough caused by cold. The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 3-9 parts of cooked aconite root, 13-18 parts of dried ginger, 8-12 parts of ginseng, 18-23 parts of stir-fried white atractylodes, 8-12 parts of roasted liquorice root, 25-35 parts of stir-fried coix seeds, 18-23 parts of poria, 8-12 parts of bupleurum root, 8-12 parts of white peony root, 8-12 parts of immature bitter orange, 3-9 parts of ephedra, 8-12 parts of apricot kernel, 8-12 parts of forsythia, 13-18 parts of gypsum, 3-9 parts of cicada slough and 25-35 parts of amethyst.

[0020] The present invention is preferably composed of the following raw materials in parts by weight: 6 parts of cooked aconite root, 15 parts of dried ginger, 10 parts of ginseng, 20 parts of stir-fried white atractylodes, 10 parts of roasted licorice, 30 parts of stir-fried coix seeds, 20 parts of poria, 10 parts of bupleurum, 10 parts of white peony root, 10 parts of immature bitter orange, 6 parts of ephedra, 10 parts of apricot kernel, 10 parts of forsythia, 15 parts of gypsum, 6 parts of cicada shell and 30 parts of purple quartz.

[0021] The present invention believes that patient's lung and spleen yang deficiency, after exogenous pathogens attack the lung or there is residual pathogenic factors not clean, or because of lung qi deficiency, promoting descending is powerless, causes dereliction of duty, produces cough, because spleen yang deficiency, no way to nourish the lung, causes prolonged illness, spleen yang deficiency simultaneously, middle jiao mediation dereliction of duty, increases the weight of the degree of cough, and soil stagnation and wood stasis, liver and gallbladder unfavorable for dispersing and dispersing qi, causes lung qi stagnation and increases the weight of together, lung, spleen, liver three zang acts together, causes cough prolonged illness, wherein, especially based on lung and spleen yang deficiency. Under this theory, for lung and spleen yang deficiency type post-infection cough patient, in warming yang and regulating qi, under the guidance of lung and cough relieving principle, founded Wenyang Liqi Xuanfei Decoction (present composition).

[0022] The present invention uses aconite and dried ginger to warm the yang as the main medicine; ginseng and white atractylodes nourish the middle and replenish qi, bupleurum can both relieve liver depression and promote clear yang, peony nourishes blood and restrains yin, and is matched with bupleurum, one ascending and the other restraining, and is assisted by bitter orange peel to disperse qi and enhance the effect of dredging qi, avoid aconite and dried ginger from excessively warming yang and transforming into fire, and at the same time promote the warming yang function to reach the lungs, improving the symptoms of lung yang deficiency; ephedra promotes lung function, relieves asthma and relieves cough, apricot kernel descends lung qi, and at the same time gypsum and forsythia assist in controlling the sweating effect of ephedra, cicada shell and purple quartz are the counter-medicines, cicada shell dispels wind and clears heat, amethyst warms the middle and lowers qi, one ascending and the other descending, and cooperates with ephedra and apricot kernel to strengthen the function of promoting lung function and relieving cough, and at the same time relieves throat itching, fried coix seed and poria assist in strengthening the spleen and removing dampness, roasted licorice relieves urgency and harmonizes the middle, and can also harmonize various medicines. In short, the present invention uses aconite and dried ginger to warm the yang, which are the main drugs; ginseng and white atractylodes nourish the middle and replenish qi, bupleurum and white peony root, one ascending and the other astringing, and tangerine peel promote qi, which can not only soothe the liver and regulate qi to avoid qi stagnation, but also lead the warming drugs upward, which are the minister drugs; coix seed and poria strengthen the spleen and eliminate dampness, ephedra, apricot kernel, gypsum, forsythia, cicada shell, and purple quartz promote lung and relieve cough, which are the adjuvant drugs; roasted licorice relieves urgency and harmonizes the middle, and can also harmonize all the drugs, and all the drugs are used together to achieve the effects of warming the yang and regulating qi, promoting lung and relieving cough.

[0023] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, comprising: mixing cooked aconite root, ginseng, gypsum and purple quartz and decocting them separately, then decocting them together with other raw materials, filtering, decocting the residue again, combining the filtrate, concentrating, standing, filling and sterilizing to obtain the composition.

[0024] The material-liquid ratio of the single decoction, the combined decoction and the decoction of the present invention is preferably 1:6-10 g / mL, more preferably 1:7.8 g / mL; the time of the single decoction is preferably 25-35 min, more preferably 30 min; the time of the combined decoction and the decoction is preferably 30-35 min, more preferably 33 min; the concentration preferably includes: concentrating the filtrate to 1.02-1.06 at 50-60°C (measured at 70°C); the standing temperature is preferably 2-5°C, more preferably 4°C, and the time is preferably 24-72 h, more preferably 36 h.

[0025] The cooked aconite root, ginseng, gypsum and purple quartz of the present invention are relatively heavy, and the decoction time is prolonged, which can eliminate the toxicity of the aconite root and facilitate the dissolution of the effective ingredients to increase the efficacy. After decoction, the effective ingredients of the traditional Chinese medicine are mixed to achieve the therapeutic effect.

[0026] The present invention also provides the use of the above-mentioned traditional Chinese medicine composition in preparing a medicine for treating post-infectious cough of lung and spleen yang deficiency type; the dosage form of the medicine is a decoction.

[0027] The prepared Wenyang Liqi Xuanfei Decoction and compound methoxyphenamine capsules are used to treat cough. Clinical experimental results show that the total effective rate of Wenyang Liqi Xuanfei Decoction is 94.44%, which is higher than 86.11% of the compound methoxyphenamine capsules, and the recurrence rate and adverse reaction rate of Wenyang Liqi Xuanfei Decoction are lower.

[0028] In the present invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

[0029] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions of the present invention. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] In the following examples, unless otherwise specified, all methods are conventional.

[0031] Example 1

[0032] Preparation of Wenyang Liqi Xuanfei Decoction

[0033] (1) Accurately weigh 6g of cooked aconite root, 15g of dried ginger, 10g of ginseng, 20g of stir-fried white atractylodes, 10g of roasted licorice root, 30g of stir-fried coix seed, 20g of poria, 10g of bupleurum root, 10g of white peony root, 10g of immature bitter orange, 6g of ephedra, 10g of apricot kernel, 10g of forsythia, 15g of gypsum, 6g of cicada shell, and 30g of purple quartz;

[0034] (2) Cooked aconite root, ginseng, gypsum, and purple quartz were mixed and decocted separately (material-liquid ratio of 1:7.8 g / mL) for 30 min, and then decocted with other raw materials (material-liquid ratio of 1:7.8 g / mL) for 33 min. After filtering, the residue was decocted again (material-liquid ratio of 1:7.8 g / mL) for 33 min;

[0035] (3) The filtrates were combined and concentrated to 1.06 at 55°C (measured at 70°C), allowed to stand at 4°C for 36 hours, filled and sterilized to obtain the Wenyang Liqi Xuanfei Decoction.

[0036] Example 2

[0037] Preparation of Wenyang Liqi Xuanfei Decoction

[0038] (1) Accurately weigh 3g of cooked aconite root, 13g of dried ginger, 8g of ginseng, 18g of stir-fried white atractylodes, 8g of roasted licorice root, 25g of stir-fried coix seed, 18g of poria, 8g of bupleurum root, 8g of white peony root, 8g of immature bitter orange, 3g of ephedra, 8g of apricot kernel, 8g of forsythia, 13g of gypsum, 3g of cicada shell, and 25g of purple quartz;

[0039] (2) Cooked aconite root, ginseng, gypsum, and purple quartz were mixed and decocted separately (material-liquid ratio of 1:6 g / mL) for 25 min, and then decocted with other raw materials (material-liquid ratio of 1:6 g / mL) for 30 min. After filtering, the residue was decocted again (material-liquid ratio of 1:6 g / mL) for 30 min;

[0040] (3) The filtrates were combined and concentrated to 1.02 at 60°C (measured at 70°C), allowed to stand at 2°C for 24 hours, filled and sterilized to obtain the Wenyang Liqi Xuanfei Decoction.

[0041] Example 3

[0042] Preparation of Wenyang Liqi Xuanfei Decoction

[0043] (1) Accurately weigh 9g of cooked aconite root, 18g of dried ginger, 12g of ginseng, 23g of stir-fried white atractylodes, 12g of roasted licorice root, 35g of stir-fried coix seed, 23g of poria, 12g of bupleurum root, 12g of white peony root, 12g of immature bitter orange, 9g of ephedra, 12g of apricot kernel, 12g of forsythia, 18g of gypsum, 9g of cicada slough, and 35g of amethyst;

[0044] (2) Cooked aconite root, ginseng, gypsum, and purple quartz were mixed and decocted separately (material-liquid ratio of 1:10 g / mL) for 35 min, and then decocted with other raw materials (material-liquid ratio of 1:10 g / mL) for 35 min. After filtering, the residue was decocted again (material-liquid ratio of 1:10 g / mL) for 30 min.

[0045] (3) The filtrates were combined and concentrated to 1.04 at 50°C (measured at 70°C), allowed to stand at 5°C for 36 hours, filled and sterilized to obtain the Wenyang Liqi Xuanfei Decoction.

[0046] Example 4

[0047] clinical trials

[0048] 1. Case selection

[0049] A total of 72 patients with post-infectious cough (lung and spleen yang deficiency type) who were treated in the outpatient department of pulmonary disease at the Affiliated Hospital of Changchun University of Chinese Medicine from May to November 2023 were randomly divided into a control group and a treatment group, with 36 cases in each group. The control group included 4 males and 32 females, aged 23 to 65 years (mean, 41.02±10.16) years; the treatment group included 9 males and 27 females, aged 25 to 57 years (mean, 40.97±8.20) years. There was no statistically significant difference in the general information between the two groups (P>0.05).

[0050] Western medicine diagnostic criteria for PIC are based on the diagnostic criteria for PIC in the "Guidelines for the Diagnosis and Treatment of Cough (2015)." After the acute symptoms of respiratory infection disappear, the cough persists, often manifesting as an irritating, dry cough or coughing up small amounts of white mucus, typically lasting three to eight weeks. X-rays are normal.

[0051] The TCM diagnostic criteria are based on the "TCM Clinical Pathways for 104 Diseases in 24 Specialties," "Expert Consensus on TCM Diagnosis and Treatment of Cough (2011 Edition)," and "Guidelines for the Diagnosis and Treatment of Cough (2021 Edition)." Clinical manifestations of TCM syndrome differentiation are as follows: Primary symptom: cough; Secondary symptoms: itchy throat, irritating dry cough, small amounts of white sputum, chills, with a certain probability of being triggered or aggravated by inhalation of irritating odors such as fumes and dust, cold air, rapid conversation, or laughing; pale tongue with a slightly greasy white coating with teeth marks on the edges, and a deep, thready pulse. If both the primary symptom and ≥2 of the secondary symptoms are met, and based on the tongue and pulse, the syndrome is diagnosed as lung and spleen yang deficiency.

[0052] The inclusion criteria included meeting the above diagnostic criteria; age 18 to 70 years old; voluntarily participating in this study and being able to receive follow-up visits, and signing the informed consent.

[0053] Exclusion criteria included the presence of underlying lung disease; taking angiotensin-converting enzyme inhibitors within the past three months; the presence of severe primary cardiovascular and cerebrovascular diseases or other systemic diseases; pregnancy, lactation, and allergy to the study drugs.

[0054] 2. Treatment Methods

[0055] Treatment group: took Wenyang Liqi Xuanfei decoction prepared in Example 1 of the present invention, 1 dose / d, decocted in water, taken in the morning and evening, for 10 days.

[0056] The control group received compound methoxyphenamine capsules (Daiichi Sankyo Pharmaceutical Co., Ltd., approved by the National Medical Products Administration, H20033669), 2 capsules / time, 3 times / day, orally for 10 days.

[0057] 3. Observation of therapeutic efficacy

[0058] Observation Indicators: Primary efficacy indicator: 1. Simple Cough Evaluation Test (CET). Secondary efficacy indicators: Leicester Cough Questionnaire (LCQ); relapse rate; safety indicators: blood routine; adverse reactions and adverse events. Indicator Description: The Simple Cough Evaluation Test (CET) includes five items: the patient's daytime cough intensity, the impact of nighttime cough on sleep, the severity of cough, and the impact of cough on daily life and psychology. Studies have confirmed that the CET has excellent test-retest reliability and response validity, and has a good correlation with VAS scores and cough quality of life questionnaires. The Leicester Cough Questionnaire (LCQ) can systematically evaluate cough intensity and efficacy, covering three aspects: physiological status, mental health, and social function. The total score of the LCQ is positively correlated with the patient's health status.

[0059] Efficacy criteria ① Clinical efficacy. The efficacy evaluation criteria were formulated with reference to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial Implementation)". Cured: clinical symptoms and signs disappear; markedly effective: clinical symptoms and signs basically disappear; effective: clinical symptoms and signs improve to some extent, with occasional coughing up white sputum; ineffective: clinical symptoms and signs do not improve or even worsen. Total effective rate = (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%. ② Simple Cough Severity Scale (CET): Fill out the Simple Cough Severity Scale, which includes five items: the patient's daytime cough intensity, the impact of nighttime cough on sleep, the severity of cough, and the impact of cough on daily life and psychology. Studies have confirmed that the CET has excellent test-retest reliability and response validity, and is well correlated with VAS scores and the Cough Quality of Life Questionnaire. ③ Leicester Cough Quality of Life Score: Fill out the Leicester Cough Quality of Life Questionnaire. There are 19 items in total, each scored 1 to 7 points based on the criteria of "always," "most of the time," "often," "sometimes," "occasionally," "hardly," and "never," for a total score of 133 points. Assessments were conducted before and after treatment. ④ Cough recurrence rate was calculated one week after discontinuation of medication: recurrence rate = number of recurrences / total number of effective cases × 100%. ⑤ Safety indicators: Adverse drug reactions and other adverse events were recorded during treatment.

[0060] 4. Statistical methods

[0061] SPSS 23.0 software was used to perform statistical analysis on the data in this paper. t test is used to express the data; count data is expressed as rate (%) and X test is used to express the data. 2 P<0.05 indicated statistically significant differences.

[0062] 5. Results

[0063] 5.1 Comparison of clinical efficacy

[0064] The results of clinical efficacy comparison between the treatment group and the control group are shown in Table 1.

[0065] Table 1 Comparison of clinical efficacy between the two groups of patients [cases (%)]

[0066] Group Number of cases Cured (case) Significantly effective (example) Valid (example) Invalid (example) Total effective (%) Treatment group 36 7 20 7 2 <![CDATA[94.44 a ]]> control group 36 1 14 15 6 83.33

[0067] Note: Compared with the control group, a P<0.05.

[0068] As shown in Table 1, the total effective rate of the treatment group was 94.44% (34 / 36), which was higher than that of the control group (86.11% (31 / 36), and the difference was statistically significant (P < 0.05).

[0069] 5.2 Comparison of CET scores before and after treatment

[0070] The results of intra-group comparison of CET scores before and after treatment and inter-group comparison after treatment in the treatment group and the control group are shown in Table 2.

[0071] Table 2 Comparison of CET scores before and after treatment in the treatment group and the control group ( point)

[0072]

[0073] Note: Compared with the group before treatment, a P<0.05; compared with the control group after treatment, b P<0.05.

[0074] As shown in Table 2, the CET scores of the treatment group and the control group were comparable before treatment and had no statistical significance. After treatment, the CET scores of the treatment group were significantly different from those before treatment and the control group (P < 0.05).

[0075] 5.3 Comparison of LCQ scores before and after treatment

[0076] The results of intra-group comparison of LCQ scores before and after treatment and inter-group comparison after treatment in the treatment group and the control group are shown in Table 3.

[0077] Table 3 Comparison of LCQ scores before and after treatment in the treatment group and the control group ( point)

[0078]

[0079]

[0080] Note: Compared with the group before treatment, a P<0.05; compared with the control group after treatment, b P<0.05

[0081] The results in Table 3 show that the LCQ scores of the treatment group and the control group were not statistically significant before treatment and were comparable. After treatment, the differences in LCQ scores of the treatment group compared with those before treatment and the control group were statistically significant (P < 0.05).

[0082] 5.4 Recurrence Rate

[0083] The recurrence rates of the treatment group and the control group are shown in Table 4.

[0084] Table 4 Comparison of recurrence rates among patients [cases (%)]

[0085] Group Total effective cases Number of recurrence cases Treatment group 34 2(5.88) control group 30 <![CDATA[8(26.66) a ]]>

[0086] Note: Compared with the control group, a P<0.05.

[0087] As shown in Table 4, the recurrence rate in the treatment group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05).

[0088] 5.5 Occurrence of adverse reactions

[0089] During treatment, no adverse reactions occurred in the treatment group, which was lower than the 8.3% in the control group. In the control group, 2 cases experienced nausea and vomiting, and 1 case experienced palpitations. Both symptoms resolved after discontinuation of Compound Methoxyphenamine Capsules. No serious adverse reactions occurred in either group.

[0090] Based on the above results, it can be seen that Wenyang Liqi Xuanfei Decoction has a significant therapeutic effect in the treatment of cough compared with Compound Methoxyphenamine Capsules, and Wenyang Liqi Xuanfei Decoction has a lower recurrence rate and adverse reaction rate.

[0091] Although the above embodiment provides a detailed description of the present invention, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating cough caused by cold, characterized in that: The invention is composed of the following raw materials in parts by weight: 3-9 parts of cooked aconite root, 13-18 parts of dried ginger, 8-12 parts of ginseng, 18-23 parts of stir-fried white atractylodes, 8-12 parts of roasted licorice root, 25-35 parts of stir-fried coix seeds, 18-23 parts of poria, 8-12 parts of bupleurum root, 8-12 parts of white peony root, 8-12 parts of immature bitter orange, 3-9 parts of ephedra, 8-12 parts of apricot kernel, 8-12 parts of forsythia, 13-18 parts of gypsum, 3-9 parts of cicada shell and 25-35 parts of purple quartz.

2. The Chinese medicine composition according to claim 1, characterized in that The invention is composed of the following raw materials in parts by weight: 6 parts of cooked aconite root, 15 parts of dried ginger, 10 parts of ginseng, 20 parts of stir-fried white atractylodes, 10 parts of roasted licorice root, 30 parts of stir-fried coix seed, 20 parts of poria, 10 parts of bupleurum root, 10 parts of white peony root, 10 parts of immature bitter orange, 6 parts of ephedra, 10 parts of apricot kernel, 10 parts of forsythia, 15 parts of gypsum, 6 parts of cicada shell and 30 parts of purple quartz.

3. The method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: include: The prepared aconite root, ginseng, gypsum and purple quartz are mixed and decocted separately, and then decocted together with other raw materials. After filtering, the medicinal residues are decocted again, and the filtrates are combined, concentrated, allowed to stand, filled and sterilized to obtain the composition.

4. The preparation method according to claim 3, characterized in that The material-liquid ratio of the single decoction, the combined decoction and the decoction is 1:6-10 g / mL.

5. The preparation method according to claim 3, characterized in that The single frying time is 25 to 35 minutes.

6. The preparation method according to claim 3, characterized in that The time for the combined decoction and the decoction is 30 to 35 minutes.

7. The preparation method according to claim 3, characterized in that The temperature of the standing state is 2-5° C., and the time is 24-72 hours.

8. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of a medicine for treating post-infectious cough of lung and spleen yang deficiency type.

9. The use according to claim 8, characterized in that The dosage form of the medicine is decoction.

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