Disposable cartridge for electrostatic applicator, system and method thereof

Abstract

A disposable fluid delivery system for an electrostatic applicator. The system includes a nozzle housing including an air supply port, a voltage port, and a delivery outlet. A voltage wire has a contact in communication with a delivery tube in fluid communication with the delivery outlet. A syringe includes a barrel portion and a plunger configured to advance fluid from within the barrel portion and through the delivery tube. A cartridge housing can at least partially enclose the nozzle housing, the voltage wire, and the syringe.

Description

[0001] Cross-reference to related applications

[0002] This application claims priority and benefit to U.S. Provisional Patent Application No. 63 / 411,334, filed September 29, 2022, and U.S. Non-Provisional Patent Application No. 18 / 110,854, filed February 16, 2023, the contents of each of which are incorporated herein by reference in their entirety, as fully set forth below. Technical Field

[0003] This disclosure relates to devices, systems, and methods for applying one or more medicaments (e.g., one or more biologics, polymer spun wound dressings, antiseptics, or anesthetics) to a treatment site (e.g., the surface of a wound on a subject). More specifically, the devices, systems, and methods are for electrostatic applicator devices having a disposable cartridge for containing multiple solutions. Background Technology

[0004] In places where they should be safe, such as ambulances, hospitals, clinical settings, and other areas (e.g., assisted living facilities), infectious diseases are acquired far too frequently. Indeed, these healthcare-associated infections (HAIs) pose a significant threat to patient safety and impose unnecessary financial burdens. For example, surgical site infections, a major contributor to HAIs, can not only cause pain and discomfort but also lead to longer hospital stays and / or repeat admissions. Many antibacterial and / or analgesic compounds are available to help treat patients and prevent infection; however, despite the prevalence of these compounds, current delivery methods are often less effective.

[0005] For example, oral and intravenous administration is often insufficient to effectively control severe pain or treat specific areas of the body, and administering high-concentration doses can lead to adverse events. To overcome some of the problems associated with oral and intravenous administration, delivery vehicles (such as hydrogels) have been developed to provide spatial and temporal control over the release of various therapeutic agents, including small molecule drugs, peptides, and cells. However, hydrogels can also have some undesirable properties, including being expensive and difficult to sterilize.

[0006] Recently, electrospraying has emerged as a technology with potential biomedical applications. Electrospraying involves applying an electrostatic charge to the fluid as it is expelled from an electrosprayer. The electric field causes the expelled liquid to break into tiny droplets, for example, on the micrometer scale, which can then be relatively uniformly bound to the treatment site with less solution. That said, not all solutions (including antiseptics and / or analgesics) respond equally to the same electrostatic conditions—differences in the viscosity and / or dielectric properties of the solution will require different optimal configurations for the electrosprayer device. Current electrosprayer devices do not offer a modular system capable of handling the various types of different solutions within a single electrosprayer device.

[0007] This disclosure addresses these and other problems in the art. Summary of the Invention

[0008] The subject of this disclosure is an electrostatic applicator for dispensing contents from a disposable cartridge (e.g., a therapeutic solution contained in the cartridge) to a patient's treatment site.

[0009] In some examples, a disposable fluid delivery system for an electrostatic applicator is disclosed. The system may include a nozzle housing comprising an air supply port, a voltage port, and a delivery outlet. A voltage line may include a contact communicating with a delivery tube in fluid communication with the delivery outlet, the voltage line being configured to be electrically connected to a high-voltage module and to electrostatically charge the fluid contents within the delivery tube. A syringe may include a barrel portion and a plunger configured to propel fluid from the barrel portion through the delivery tube. A housing may at least partially enclose the nozzle housing, voltage line, and syringe.

[0010] In some examples, the voltage tube is electrically connected to the voltage port, wherein the voltage line extends between the contact in communication with the delivery tube and the contact port of the wall of the housing.

[0011] In some examples, voltage tubes and voltage lines include a generally S-shaped configuration.

[0012] In some examples, voltage tubes and voltage lines include substantially curved shapes.

[0013] In some examples, voltage tubes and voltage lines include linear shapes.

[0014] In some examples, the syringe contains a fluid, which includes one or more of the following: antiseptic, disinfectant solution, analgesic, exosome, biological agent, and / or liquid bandage solution.

[0015] In some examples, the analgesics include one or more of lidocaine, levobupivacaine, acemetacin, ketorolac, and ceftazidime.

[0016] In some examples, the biologics include one or more of stem cells and / or mammalian cells.

[0017] In some examples, the box shell is made of moldable plastic material.

[0018] In some examples, the housing includes multiple segments of moldable plastic that can be joined to create a single integrated component.

[0019] In some examples, the contacts of the voltage line include a line loop that at least partially surrounds the outer surface of the delivery tube to provide a voltage potential of about 1V to about 40kV.

[0020] In some examples, the contacts of the voltage line are in physical contact with the outer surface of the delivery tube to provide a voltage potential of about 1V to about 40kV.

[0021] In some examples, the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from the air supply port and fluid from the syringe barrel portion and discharge fluid charged by the voltage line in equal proportions.

[0022] In some examples, the disposable box includes an air supply tube connected to an air supply port.

[0023] In some examples, the system includes a reusable electrostatic applicator comprising a housing chamber sized and shaped to receive a housing. The reusable electrostatic applicator includes a high-voltage module configured to be electrically connected to a voltage line. A piston can be positioned adjacent to the housing chamber and configured to advance a plunger surrounding the housing when the housing is assembled with the housing chamber.

[0024] In some examples, the reusable electrostatic applicator includes: a motor configured to move a piston; one or more processors; and a memory storing instructions that, when executed by the one or more processors, cause the reusable electrostatic applicator to receive an activation signal, output a control signal to the motor to actuate the piston, and output a control signal to a switch to supply voltage from a high-voltage module to a voltage line.

[0025] In some examples, the motor is a stepper motor, a linear actuator, a worm gear motor, and / or a planetary gear motor.

[0026] In some examples, the motor is a driveable actuator system that uses power transmission to apply force.

[0027] In some examples, the reusable electrostatic applicator includes a display screen, and the activation signal is an input from the user on the display screen.

[0028] In some examples, the reusable electrostatic applicator also includes an actuator, and the activation signal is a user input received by the actuator.

[0029] In some examples, the reusable electrostatic applicator includes: a housing base including a voltage source; a device housing including a chamber; and a handle extending between the housing base and the device housing.

[0030] In some examples, the chamber is positioned within the device housing such that the actuator is positioned below the chamber relative to the horizontal direction.

[0031] In some examples, the reusable electrostatic applicator includes a wireless antenna, and the activation signal is a wireless signal received from a remote external user device.

[0032] In some examples, an electrostatic applicator system for delivering a therapeutic solution to a target site is disclosed. The system may include a portable, reusable electrostatic applicator comprising: a device housing configured for handheld use; a motor configured within the device housing to drive a piston; a voltage source within the device housing; a high-voltage module electrically connected to the voltage source; and a cartridge chamber. A disposable cartridge is removably insertable into the cartridge chamber and includes a nozzle housing comprising an air supply port, a voltage port, and a delivery outlet. A voltage line is provided with contacts communicating with a delivery tube in fluid communication with the delivery outlet. A syringe is provided with a barrel portion and a plunger configured to propel fluid distally from within the barrel portion and through a delivery tube. A cartridge housing is included that at least partially surrounds the nozzle housing, the voltage line, and the syringe.

[0033] In some examples, voltage lines and voltage tubes include voltage lines within a housing, and the voltage lines include linear and / or curved or substantially S-shaped shapes.

[0034] In some examples, the box shell is made of moldable plastic material.

[0035] In some examples, the housing includes multiple moldable plastic connecting sections.

[0036] In some examples, the chamber includes a wall comprising high-voltage contacts electrically connected to a high-voltage module and an air supply port fluidly connected to a pump positioned within the device housing. A voltage line may be electrically connected to the high-voltage contacts of the wall. The contacts of the voltage line may physically contact the outer surface of the delivery tube to provide a voltage potential of approximately 1V to approximately 40kV.

[0037] In some examples, the HV module includes multiple rotatable diodes, such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotatable diodes.

[0038] In some examples, the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system.

[0039] In some examples, the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from the air supply port and fluid from the syringe barrel portion and discharge fluid charged by the voltage line in equal proportions.

[0040] In some examples, the device housing includes a handle, and a voltage source is disposed within the housing base of the device housing, wherein the handle is disposed between the device housing and the housing base.

[0041] In some examples, the reusable electrostatic applicator includes one or more processors and a memory storing instructions that, when executed by one or more processors, cause the reusable electrostatic applicator to receive an activation signal and output a control signal to a motor that controls: (a) the voltage potential from the high-voltage module via a voltage line to the delivery tube, (b) the position of the piston and plunger of the disposable cartridge, and / or (c) a pump that regulates the airflow from the device housing to the air supply port via an air supply tube.

[0042] In some examples, the disposable cartridge includes an integrated memory containing information relating to operating parameters of the contents stored in the syringe and / or another fluid reservoir within the disposable cartridge. One or more processors of the reusable electrostatic applicator are configured to communicate with the integrated memory to retrieve information relating to the contents of the disposable cartridge and to control at least one of the flow rate, voltage potential, and nozzle settings.

[0043] In some examples, the disposable cartridge includes an integrated memory containing information related to operating parameters of the contents stored in the syringe and / or another fluid reservoir within the cartridge. One or more processors of the reusable electrostatic applicator are configured to communicate with the integrated memory to retrieve information related to the contents of the disposable cartridge and to control motor speed, air intake, and / or applied voltage.

[0044] In some examples, the memory is embedded in the processor of the electrostatic applicator system and includes operating instructions for operating the electrostatic applicator system.

[0045] In some examples, Near Field Communication (NFC) tags include memory.

[0046] In some examples, the instructions also include reading NFC information related to the operating parameters of the disposable box; and displaying at least some of the read NFC information (e.g., information such as the identification of the contents, volume, etc.) on a display screen. In some aspects, the information may be written to the NFC by the processor of the electrostatic applicator system.

[0047] In some examples, the applicator includes a display screen, and the activation signal is a user input to the display screen.

[0048] In some examples, the applicator includes an actuator, and the activation signal is user input received by the actuator.

[0049] In some examples, the applicator includes a communication system within the applicator's CPU. The communication system may include a wireless antenna (e.g., one or more transceivers may be compatible with short-range wireless communication connections), and the activation signal is a wireless signal received from an external user device.

[0050] In some examples, the applicator includes an accelerometer configured to output a movement signal to one or more processors in response to detecting movement of the electrostatic applicator system.

[0051] In some examples, the applicator includes a display screen on an electrostatic applicator system, which is activated in response to a wake-up signal received from one or more processors of a movement signal, and the activation signal is a user input to the display screen.

[0052] In some examples, the electrostatic applicator system also includes a proximity sensor configured to detect the distance between the system and the intended target. In response to the distance being within a predetermined distance threshold, one of the control signals is output to a motor. In some examples, the predetermined distance threshold can be between about 2 inches and about 18 inches, but is most preferably between about 4 inches and about 6 inches. In response to the distance being within the predetermined distance threshold, one of the control signals is output to a switch to control the voltage of the electrostatic applicator system.

[0053] In some examples, the electrostatic applicator system also includes a proximity sensor configured to detect the distance between the system and the intended target, wherein, in response to the distance being greater than or less than a predetermined distance threshold, one of the control signals is output to prevent operation of the motor.

[0054] In some examples, the electrostatic applicator system also includes a proximity sensor configured to detect the distance between the system and the intended target, wherein, in response to the distance being greater than or less than a predetermined distance threshold, one of the control signals is output to a switch to prevent voltage delivery by the electrostatic applicator system.

[0055] In some examples, a method for operating an electrostatic applicator system is disclosed. The method may include inserting a first disposable cartridge into the chamber housing of the electrostatic applicator system such that a voltage contact at a first end of a voltage line within the first disposable cartridge contacts a voltage contact of the electrostatic applicator system; a first end of an air supply port within the first disposable cartridge is fluidly connected to an air supply port of the electrostatic applicator system; and a plunger of a syringe within the first disposable cartridge is aligned with a piston of the electrostatic applicator system, the syringe containing a first fluid. The method may include actuating a motor via an activation input to the electrostatic applicator system and delivering a voltage potential to a delivery tube of the first disposable cartridge.

[0056] In some examples, an actuated motor and a delivered voltage potential cause a first fluid to be propelled from the syringe through a delivery tube and sprayed as atomized, electrostatically charged droplets onto a target site in a predetermined spray pattern. In some aspects, the target site may carry an opposite charge relative to the droplets. In some aspects, the path of maximum voltage potential may be between the target site and the charged droplets, although the target site may not specifically carry an opposite charge.

[0057] In some examples, an actuated motor and a voltage potential are delivered to propel a first fluid from the syringe through a delivery tube and spray it as atomized, electrostatically charged droplets, which are carried in a predetermined spray pattern to a target site with the opposite charge.

[0058] In some examples, the method may include removing a first disposable cartridge from the chamber housing; and inserting a second disposable cartridge into the chamber housing, wherein the second disposable cartridge contains a second fluid.

[0059] In some examples, the second disposable cartridge is configured for electrospinning. The method may include: actuating a motor via a second activation input to an electrostatic applicator system, and delivering a voltage potential to the delivery tube of the second disposable cartridge, such that a second fluid from the syringe of the second disposable cartridge is delivered from the delivery tube of the second disposable cartridge as electrospinning fibers to a target site (e.g., at a predetermined rate and / or emission pattern). In some examples, the second fluid may have fibers suspended in the second fluid prior to the formation of the electrospinning fibers.

[0060] In some examples, the first disposable cartridge and the second disposable cartridge each include an integrated memory containing information related to operating parameters of the first fluid and the second fluid, respectively, and wherein inserting the first disposable cartridge or the second disposable cartridge into the chamber housing causes the operating parameters to be transmitted to the memory of the electrostatic applicator system. The operating parameters include the speed of the motor, the air intake, and the voltage applied to the delivery tube of the respective disposable cartridge.

[0061] In some examples, the method may include, after inserting one of the first or second disposable boxes into the chamber housing, marking a registry associated with information about the operating parameters of the first or second disposable box as a used box; and, when it is determined that the first or second disposable box is a used box, preventing motor actuation and / or preventing voltage or potential delivery to the delivery tube of the first or second disposable box.

[0062] In some examples, the first disposable box and the second disposable box contain different fluids.

[0063] In some examples, the first disposable cartridge and the second disposable cartridge include at least one of a first fluid and / or a second fluid stored within the respective disposable cartridge, depending on the different voltage lines and different delivery tubes of the respective nozzle housings.

[0064] In some examples, providing activation input includes inputting information related to the first fluid into a display screen on the electrostatic applicator system and providing the input to the display screen.

[0065] In some examples, the method includes pairing the electrostatic applicator system to an external user device via a short-range wireless connection, wherein providing activation input includes inputting information related to a first fluid to the external user device and providing the input to the display screen of the external user device.

[0066] In some examples, a computer-implemented method for operating an electrostatic applicator system is disclosed. The method includes: actuating a motor and / or delivering a voltage potential via a voltage line of a disposable cartridge from a high-voltage module of the electrostatic applicator system to a delivery tube of the disposable cartridge, which is detachably attached to the chamber housing of the electrostatic applicator system, by means of an activation input to the electrostatic applicator system; actuating a plunger of a syringe to pass fluid contents propelled from the syringe through the delivery tube; electrostatically charging the fluid contents in the delivery tube via the voltage line; and discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge onto a treatment site.

[0067] In some examples, the method may include electrostatically charging the fluid contents in the barrel portion of the syringe near the delivery tube via a voltage line.

[0068] In some examples, the step of ejecting electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from the air supply of the electrostatic applicator system into a disposable cartridge to atomize the electrostatically charged fluid contents into droplets of a predetermined spray pattern onto the target site.

[0069] In some examples, the step of emitting electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers.

[0070] In some examples, the method includes: detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and, in response to the distance being within a predetermined distance threshold, transmitting an activation input to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0071] In some examples, the method includes: detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and preventing motor actuation and / or preventing the high-voltage module from delivering voltage potential in response to the distance being greater than or less than a predetermined distance threshold.

[0072] In some examples, the method includes: activating a wake-up signal from one or more processors via a display screen on the electrostatic applicator system in response to one or more processors receiving a movement signal; and causing an activation input to be transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential in response to the wake-up signal.

[0073] In some examples, the disposable cartridge includes an integrated memory that contains information relating to operating parameters of the fluid contents stored within the syringe. In this regard, the method may include: communicating with the integrated memory via one or more processors of a reusable electrostatic applicator to retrieve information relating to the fluid contents of the disposable cartridge; and controlling at least one of flow rate, voltage potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, including motor speed, air intake, and / or the applied voltage to the disposable cartridge.

[0074] In some examples, the memory is embedded in the processor of the electrostatic applicator system and includes operating instructions for operating computer-implemented methods of the electrostatic applicator system.

[0075] In some examples, a system for operating an electrostatic applicator system is disclosed. The system may include at least one memory storing instructions and at least one processor configured to execute the instructions to perform operations. In some aspects, the operations may include: actuating a motor and / or delivering a voltage potential from a high-voltage module of the electrostatic applicator system via a voltage line of a disposable cartridge to a delivery tube of a disposable cartridge removably attached to a chamber housing of the electrostatic applicator system by means of an activation input to the electrostatic applicator system; pushing a plunger of a syringe through the delivery tube to allow fluid contents propelled from the syringe from the disposable cartridge to pass through the delivery tube; electrostatically charging the fluid contents via the voltage line while they are in the delivery tube; and discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge onto a treatment site.

[0076] In some examples, the step of ejecting electrostatically charged fluid contents from the nozzle assembly includes controlling air intake from an air pump within the electrostatic applicator into a disposable cartridge to atomize the electrostatically charged fluid contents into droplets of a predetermined spray pattern onto a target site with the opposite charge.

[0077] In some examples, the step of ejecting electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers to a target site having a voltage potential difference at a predetermined rate and / or pattern.

[0078] In some examples, the operation includes: detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and, in response to the distance being within a predetermined distance threshold, causing an activation input to be transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0079] In some examples, the operation includes: in response to one or more processors of the electrostatic applicator system receiving a movement signal, activating a wake-up signal from one or more processors by a display screen on the electrostatic applicator system; and in response to the wake-up signal, causing an activation input to be transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0080] In some examples, the disposable cartridge includes an integrated memory containing information related to operating parameters of the fluid contents stored within the syringe. Operation in this regard may include: communicating with the integrated memory via one or more processors of a reusable electrostatic applicator to retrieve information related to the fluid contents of the disposable cartridge; and controlling at least one of flow rate, voltage potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, including motor speed, air intake, and / or the applied voltage to the disposable cartridge.

[0081] In some examples, the memory is embedded in the processor of the electrostatic applicator system and includes operating instructions for operating computer-implemented methods of the electrostatic applicator system.

[0082] In some examples, a non-transitory computer-readable medium storing instructions that, when executed by a processor, cause the processor to perform a method for operating an electrostatic applicator system. The method may include: actuating a motor and / or delivering a voltage potential from a high-voltage module of the electrostatic applicator system via a voltage line of a disposable cartridge to a delivery tube of the disposable cartridge, which is removably attached to a chamber housing of the electrostatic applicator system, via an activation input to the electrostatic applicator system; pushing a plunger of a syringe via a motor to pass fluid contents propelled from the syringe from the disposable cartridge through the delivery tube; electrostatically charging the fluid contents via the voltage line while they are in the delivery tube; and discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge onto a treatment site.

[0083] In some examples, the step of ejecting electrostatically charged fluid contents from the nozzle assembly includes controlling air intake from an air supply unit of the electrostatic applicator system into a disposable cartridge to atomize the electrostatically charged fluid contents into droplets of a predetermined spray pattern onto a target site with the opposite charge. In some examples, the predetermined spray pattern may include droplets becoming similarly electrostatically charged and repelled by other droplets in the droplet group when attracted toward the target site with the opposite charge. In some examples, the droplets may be positively charged, and the target site may be negatively charged. In some examples, the droplets may be negatively charged, and the target site may be positively charged.

[0084] In some examples, the step of emitting electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers to a target site with the opposite charge at a predetermined rate and / or pattern.

[0085] In some examples, the method includes: detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and, in response to the distance being within a predetermined distance threshold, transmitting an activation input to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0086] In some examples, the method includes: activating a wake-up signal from one or more processors of the electrostatic applicator system via a display screen on the electrostatic applicator system in response to one or more processors receiving a movement signal; and causing an activation input to be transmitted in response to the wake-up signal to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0087] In some examples, the disposable cartridge includes an integrated memory that contains information relating to one or more operating parameters of the fluid contents stored within the syringe. The method may include: one or more processors of a reusable electrostatic applicator communicating with the integrated memory to retrieve information relating to the fluid contents of the disposable cartridge; and controlling at least one of flow rate, voltage potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, including motor speed, air intake, and / or the applied voltage to the disposable cartridge.

[0088] To achieve the foregoing and related objectives, certain illustrative aspects have been described herein in conjunction with the following description and accompanying drawings. However, these aspects merely indicate a few of the different ways in which the principles of the claimed subject matter can be employed, and the claimed subject matter is intended to encompass all such aspects and their equivalents. Other advantages and novel features will become apparent from the following detailed description when considered in conjunction with the accompanying drawings. Attached Figure Description

[0089] The above and further aspects of the invention are further discussed in conjunction with the accompanying drawings, wherein like reference numerals denote like structural elements and features throughout the drawings. The drawings are not necessarily drawn to scale, but rather focus on illustrating the principles of the invention. The drawings illustrate one or more embodiments of the apparatus of the invention by way of example only and not limitation.

[0090] Figure 1A A perspective view of an example electrostatic applicator positioned in a decomposed state with an example base is depicted.

[0091] Figure 1B The positioning of the example base in the decomposed state is depicted. Figure 1A A side view of an example electrostatic applicator.

[0092] Figure 1C The image depicts the positioning of an example base in an assembled state. Figure 1A A side view of an example electrostatic applicator.

[0093] Figure 2A Depicting Figure 1A-1C A perspective view of an example electrostatic applicator with a disposable box in a disassembled state.

[0094] Figure 2B Show Figure 1A-1C The state of decomposition has Figure 2A A perspective view of an example electrostatic applicator for a disposable box.

[0095] Figure 3 Depicting Figure 1A A side view of an example electrostatic applicator with a portion of its outer casing removed.

[0096] Figure 4A Show Figures 1A to 2B The front perspective of the example box.

[0097] Figure 4B Show Figures 1A to 2B The back perspective of the example box.

[0098] Figure 5A Show Figures 1A to 2B The lower rear perspective view of the example box.

[0099] Figure 5B Depicting Figures 1A to 2B A side view of an example box in which part of its outer shell has been removed.

[0100] Figure 5C Depicting Figures 1A to 2B An exploded perspective view of the internal components of an example box whose outer shell has been removed.

[0101] Figure 6 Depicting from Figure 3 A close-up cross-sectional view of section 6, which shows Figures 1A to 3 Aspects of an example box with an electrostatic applicator in the closed position.

[0102] Figure 7A Depicting Figure 3 A close-up cross-sectional view of an example aspect, showing the closed system in the air inlet and outlet relative to the example electrostatic applicator and the example box.

[0103] Figure 7B Depicting something similar to Figure 7A A close-up cross-sectional view, but the example valve seal is in the open position.

[0104] Figure 8A Depicting the previous Figures 1A to 3 A side cross-sectional view of an example aspect of the actuator is shown in the figure.

[0105] Figure 8B Depicting what was previously intended for use with Figures 1A to 3 A side cross-sectional view of another example actuator used in conjunction with the example.

[0106] Figure 9A Depicting the intended use with Figures 1A to 3 A front perspective view of an example electrospinning box used with an example electrostatic applicator.

[0107] Figure 9B Depicting the intended use with Figures 1A to 3 The rear perspective view of an example electrospinning box used with an example electrostatic applicator.

[0108] Figure 10A Depicting Figures 9A-9B The lower rear perspective view of the example box.

[0109] Figure 10B Depicting Figures 9A-9B A side view of an example box in which part of its outer shell has been removed.

[0110] Figure 10C Depicting Figures 9A-9B An exploded perspective view of the internal components of an example box in which part of the outer shell has been removed.

[0111] Figure 11A Depicting the intended use with Figures 1A to 3 A perspective view of the internal components of an example electrostatic box used with an example electrostatic applicator, which includes a pair of syringes and an electrostatic nozzle.

[0112] Figure 11B Depicting Figure 11A The example internal component shown is a side cross-sectional view.

[0113] Figure 12A Depicting the intended use with Figures 1A to 3 A perspective view of the internal components of an example electrostatic box used with an example electrostatic applicator, the components including a pair of syringes, at least one electrostatic nozzle, and at least one electrospinning delivery tube.

[0114] Figure 12B Depicting Figure 12A The example internal component shown is a side cross-sectional view.

[0115] Figure 13A Depicting the intended use with Figures 1A to 3 A perspective view of the internal components of an example electrostatic box used with an example electrostatic applicator, which includes a pair of syringes and an electrospinning delivery tube interconnected by a Y-shaped member.

[0116] Figure 13B Depicting Figure 13A The example internal component shown is a side cross-sectional view.

[0117] Figure 14A A side perspective view depicts an example cone configured for use with any of the nozzles disclosed herein for use with the described disposable cartridge.

[0118] Figure 14B A side perspective view of another example cone configured for use with any of the nozzles disclosed herein for the described disposable cartridge is depicted.

[0119] Figure 14C A side perspective view of another example cone configured for use with any of the nozzles disclosed herein for the described disposable cartridge is depicted.

[0120] Figure 14D A side perspective view of another example cone configured for use with any of the nozzles disclosed herein for the described disposable cartridge is depicted.

[0121] Figure 15 This is a component diagram of the different parts and systems that may be included in the electrostatic and / or electrospinning apparatus according to this disclosure.

[0122] Figure 16 Based on this disclosure Figure 15 A diagram of the components of the user interface.

[0123] Figure 17 Based on this disclosure Figure 15 Component diagram of the controller.

[0124] Figure 18This is a flowchart of an example process for operating an electrostatic applicator and a disposable box system according to this disclosure.

[0125] Figure 19 This is a flowchart of an example process for operating an electrostatic applicator and a disposable box system according to this disclosure.

[0126] Figure 20 This is a flowchart of an example process for operating an electrostatic applicator and a disposable box system according to this disclosure.

[0127] Figure 21 This is a flowchart of an example process for operating an electrostatic applicator and a disposable box system according to this disclosure.

[0128] Figure 22 This is a flowchart of an example process for operating an electrostatic applicator and disposable cartridge system with an interactive component that provides feedback to the user about the status of the device, according to the present disclosure.

[0129] Figure 23 This is a flowchart of an example process for operating an electrostatic applicator and disposable cartridge system with an interactive component that provides feedback to the user about the status of the device, according to the present disclosure.

[0130] Figure 24 This is a flowchart of an example process for operating an electrostatic applicator and disposable cartridge system with an interactive component that provides feedback to the user about the status of the device, according to the present disclosure.

[0131] Figure 25 This is a flowchart of an example process for operating an electrostatic applicator and disposable cartridge system with an interactive component that provides feedback to the user about the status of the device, according to the present disclosure.

[0132] Figure 26 This is a flowchart of an example process for operating an electrostatic applicator and disposable cartridge system with an interactive component that provides feedback to the user about the status of the device, according to the present disclosure.

[0133] Figure 27 This is a flowchart of an example process for operating an electrostatic applicator and disposable cartridge system with an interactive component that provides feedback to the user about the status of the device, according to the present disclosure.

[0134] Figure 28 This is a flowchart, according to the present disclosure, for providing feedback to a user regarding the optimal applicator and disposable cartridge system positioning using proximity sensors.

[0135] Figure 29 This is a flowchart of an example applicator and a disposable box system used in accordance with this disclosure.

[0136] Figure 30 This is a flowchart of an example applicator and a disposable box system used in accordance with this disclosure.

[0137] Figure 31 This is a flowchart illustrating the operation of an example electrostatic applicator system according to this disclosure.

[0138] Figure 32 This is a flowchart of a computer-implemented method for operating any electrostatic applicator system of this disclosure. Detailed Implementation

[0139] While exemplary embodiments of the disclosed technology have been explained in detail herein, it should be understood that other embodiments are contemplated. Therefore, the disclosed technology is not intended to limit its scope to the details of the construction and arrangement of the components set forth in the following description or shown in the accompanying drawings. The disclosed technology is capable of having other embodiments and can be practiced or implemented in various ways.

[0140] It should be noted that, as used in the specification and appended claims, the singular forms “a,” “an,” and “the” include the plural forms unless the context clearly indicates otherwise. “Comprising,” “containing,” or “including” means that at least the specified compound, element, particle, or method step is present in the composition, article, or method, but does not exclude the presence of other compounds, materials, particles, or method steps, even if such other compounds, materials, particles, or method steps have the same function as those specified.

[0141] In this disclosure, relative terms such as “about,” “substantially,” or “approximately” are used to indicate possible variations of ±10% in the value.

[0142] In describing the example embodiments, terminology will be used for clarity. Each term is intended to be considered in its broadest sense as understood by one skilled in the art, and includes all technical equivalents that operate in a similar manner to achieve a similar purpose. It should also be understood that reference to one or more steps of a method does not exclude the presence of additional method steps or intermediate method steps between those expressly identified steps. The steps of a method may be performed in a different order than that described herein without departing from the scope of the disclosed technology. Similarly, it should be understood that reference to one or more components in an apparatus or system does not exclude the presence of additional components or intermediate components between those expressly identified components.

[0143] As discussed herein, the treatment site for the "subject" or "patient" can be a wound site or treatment on a human or any animal. It should be understood that the animal can be any applicable type, including but not limited to mammals, veterinarian animals, livestock animals, or pet-type animals. As an example, the animal can be a laboratory animal specifically selected to have certain characteristics similar to humans (e.g., rats, dogs, pigs, monkeys, etc.). It should be understood that, for example, the subject can be any applicable human patient.

[0144] As discussed herein, “operator” may include, but is not limited to, a physician, surgeon, nurse, physical therapist, or other medical professional, or any other suitable individual, or a delivery instrument associated with the application of a treatment solution to the treatment site of the subject.

[0145] As discussed herein, a “treatment solution” can be one or more fluids (e.g., liquid and / or emulsion solutions, gels, and / or mixtures) and can include one or more of the following: antiseptic solutions, disinfectant solutions, analgesics, exosomes, biologics, chlorohexidine gluconate, povidone-iodine, and / or liquid bandage solutions. Analgesics can include one or more of the following: lidocaine, levobupivacaine, acemetacin, ketorolac, and ceftazidime. Biologics can include one or more of the following: stem cells and / or primary mammalian cells, drugs, gels (e.g., hydrogels), and reconstitutable aspects (e.g., immiscible and / or lyophilized components that are miscible with one or more solvents). Disinfectants may include one or more alcohols, aldehydes, oxidatives, phenols, quaternary ammonium compounds, preservatives, biguanides, analgesics, surfactants, and / or debridement components, or any other contents and / or medicines intended for storage in a box disclosed herein, that can be delivered (e.g., applied, deposited, and / or sprayed) to a patient's treatment site. Treatment solutions may include any concentration or mixture of the ingredients disclosed herein.

[0146] The term "therapeutic solution" may also include one or more tracking materials (e.g., a gel with tracking properties, mixed with the therapeutic solution). Therapeutic solutions may include any number of small molecule drugs, peptides, cells, and other therapeutic agents. In some aspects, the therapeutic solution may include one or more active pharmaceutical ingredients, growth factors, trophic factors, exosomes, mammalian regenerative cells, and / or a supportive matrix. In some aspects, the therapeutic solution may include lidocaine, levobupivacaine, asimexine, ketorolac, etc., or any combination thereof.

[0147] The terms “distal” or “proximal” are used in the following description of location or orientation relative to a reference point (e.g., the user [e.g., a therapist or interventional therapist]). “Distal” or “distally” means a location remote from or in a direction remote from the reference point. “Proximal” or “proximal” or “near” means a location near or in a direction toward the reference point.

[0148] Increasing amounts of care and resources have been focused on creating effective treatments for pain and infection care. The most common methods for treating pain and infection include oral and intravenous (IV) administration. While these methods are prevalent, they often lack the efficacy of traditional drug delivery methods. For example, when administered orally or via IV, their therapeutic effect is broad and not local—the drug targets the entire patient rather than the site of treatment. To overcome some of these problems, delivery vehicles such as localized therapeutic and, more specifically, hydrogel compounds have been developed to provide spatial and temporal control over the release of various therapeutic agents, including small molecule drugs, peptides, and cells. However, these processes can also have drawbacks. These typically synthetically produced carriers of therapeutic agents can be expensive, and because they are fragile polymer chains, sterilizing the polymer chains of solution / hydrogel combinations can be difficult.

[0149] Recently, the concept of electrospraying therapeutic solutions (including antibacterial and / or analgesic solutions) to the treatment site has been considered. Electrospraying is a technique that subjectes the treatment fluid to an electric field to charge the fluid. The electric field provided by a voltage source can generate a charge (e.g., positive or negative) on the applied fluid. This is particularly helpful in the biomedical field because the natural resting state of human cells is negative (i.e., a negatively charged state). This imbalance is caused by potassium and sodium ions inside and outside the cells, which build up capacitance within the patient's body. This polarity difference creates a natural attraction between the treatment site and the sprayed solution.

[0150] However, negative / positive attraction is not the only benefit of electrostatic spraying. For example, subjecting the fluid to this electric field can also produce tiny droplets (e.g., micrometer-sized), thus providing a relatively uniformly distributed layer of therapeutic solution. When electrical stress due to charge builds up in the droplet beyond its surface tension, the droplet breaks down and / or atomizes into very fine droplets—a process known as Rayleigh disintegration or Coulomb fission. As discussed herein, the term “atomization” should be understood as some or all of the process of converting a substantially liquid solution into very fine particles or droplets. The solvent dielectric constant or conductivity can play a decisive role in controlling particle morphology. Other factors influencing the atomization mode of a liquid include vapor pressure, viscosity and miscibility of the therapeutic solution, voltage applied to the solution, etc.

[0151] Note that existing designs for electrospray devices do not take into account these different types of parameters. This is because most prior art electrostatic devices focus on spraying one type of solution—consider common examples such as inkjet sprayers, paint sprayers, etc., which spray a consistent solution at a consistent flow rate and a consistent voltage potential. Furthermore, these types of applications do not focus on operating parameters. This disclosure provides a solution that can maintain the sterility of each administration of a therapeutic solution by providing a personalized, pre-filled, disposable cartridge housing the components for electrospraying. Furthermore, each disposable cartridge can be individually customized and / or communicate with a reusable electrostatic applicator to individually customize the parameters required to deliver preferred particle (e.g., nanoparticle to microparticle) droplets for targeted therapy.

[0152] Turn to the attached diagram. Figure 1AAn example applicator 100 positioned in a disassembled state with an example base 80 is provided. According to this disclosure, the applicator 100 can be used in conjunction with a disposable cartridge 50. The applicator 100 may include an applicator housing 10, which may include an upper portion 31, a lower base portion 30 located in a lower section, and a handle portion 15 between portions 30 and 31. A forward-facing cartridge support portion 32 may also be positioned between portions 30 and 32. In some respects, obtuse angles may be formed between aspects of the outer surfaces of portions 30 and 32, and the handle portion 15 may be orthogonal to portions 30 and / or 31. And although shown as a handheld pistol-shaped device, there is no requirement that the reusable applicator 100 have a pistol-shaped design, as the components herein can also be incorporated into other electrosprayer designs, such as, but not limited to, fully cylindrical handheld electrosprayer designs.

[0153] As in Figure 3 As shown more clearly in the diagram, portion 30 may house a battery B that provides a voltage potential to generate an electric field at the nozzle assembly 60 of cartridge 50, and / or to power components of applicator 100 (e.g., CPU and / or HV module 86). Battery B may include one or more batteries, including, for example, DC batteries such as lithium-ion batteries. Battery B may provide sufficient voltage to generate the aforementioned voltage potential, including but not limited to about 1V to about 40kV. In some examples, this range may be about 1V to 8kV. In some examples, the voltage supply of battery B may be one or more rechargeable batteries. In this example, aspects of applicator 100 (such as portion 32) may engage with charging base 80, which may then charge the voltage supply of battery B (e.g., inductively) when the device is not in use. Portion 30 may be configured to detach from charging base 80 by pressing an electrostatic applicator release device (not shown). In some examples, the applicator 100 may include an actuator, such as a button 35 that can activate and / or actuate a component of the applicator 100. For example, the button 35 may be activated from battery B (see [link to relevant documentation]). Figure 3 Power is activated from battery B, which may include a rechargeable module battery such as a DC battery. By activating and / or starting the power from battery B, the system is powered to charge the liquid solution in the cartridge via direct charging, inductive charging, indirect charging, or any combination thereof. In the case of direct charging, the liquid solution in the cartridge may flow through an electrically conductive tube or other conduit, allowing the liquid solution to come into contact with and be charged through direct contact.

[0154] In some examples, battery B can power components of the high-voltage (HV) module 86, air pump 83, circuit board 64, target sensor 45, motor 90, user interface 87, one or more processors (e.g., central processing unit (CPU)) of applicator 100, and cartridge 50. As will be described in more detail below, applicator 100 may include other features that eliminate the need for button 35, including, for example, an accelerometer, activation input from a user device, etc.

[0155] The applicator housing 10 may include a cartridge chamber 27, the size and position of which are configured to receive a housing 49 of a disposable cartridge 50, as explained in more detail below (see [link to documentation]). Figure 2A-4B The chamber 27 may include a distal step 29 through which connection ports of internal components of the housing 10 can be connected to various aspects of the housing 50 (e.g., air supply ports). Although Figure 1A-1C The example shown positions the cartridge chamber 27 on top of the gun-shaped, portable, cordless, reusable applicator 100, but the cartridge chamber 402 does not need to be positioned in this way. For example, the cartridge chamber 27 could be positioned on the side of the applicator 100 (e.g., on the side of the housing 10 of the applicator 100, or any other location). In some aspects, the HV module 86 may include electrical components for powering components for charging and spraying the liquid solution into the cartridge 50. For example, the HV module 86 may include components for supplying power from voltage line 92c through port 92a of the cartridge 50 to line 92d to control the voltage of the liquid solution applied to the cartridge 50 and / or for supplying power to actuate the plunger 71 (or for operating a motor 90 that includes a syringe 70 that pushes the plunger 71) to control the flow rate of the liquid solution from the cartridge 50 and through the nozzle assembly 60.

[0156] In some aspects, the HV module 86 may be configured to adjust or otherwise control operating aspects of the housing 50, including but not limited to frequency, duty cycle, and input voltage, thereby producing different output voltages with different efficiencies. In some aspects, the HV module 86 may be a closed-loop system that monitors the output voltage and adjusts input parameters to optimize the output to the desired voltage for the housing 50. The HV module 86 may also be configured to generate positive high voltages and / or negative high voltages using the same board. In some aspects, the HV module 86 may include a double-sided printed circuit board to minimize the footprint used within the housing 10. In some aspects, the HV module 86 may include a dedicated module for generating positive high voltages. In some aspects, the HV module 86 includes a plurality of diodes configured to physically rotate (e.g., rotate approximately 180°). In some aspects, the diodes may be configured to rotate or otherwise adjust their orientation based on system operating commands. In this rotation, in this example, the HV module 86 is configured to flip the polarity of its diode in the multiplier stage, enabling the HV module 86 to generate positive and negative high voltages depending on the orientation of the rotatable diode. In some aspects, the HV module 86 may include a first positive high voltage multiplier system and a second negative high voltage multiplier system physically independent of the first positive high voltage multiplier system. Each subsystem of the HV module 86 may be located on the same circuit board and may be selectively actuated during operation of the applicator 100 as needed or required. In some aspects, each of the subsystems may be located on a separate circuit board.

[0157] The applicator 100 may include one or more processors, such as a CPU, which facilitate the activation of the applicator 100, receive and output signals related to voltage, flow rate, proximity, etc., for a particular liquid therapeutic solution.

[0158] Within the housing 10, the applicator 100 may include a piston 94 and a corresponding motor 90 for actuating the injector 70. The piston 94 may be positioned between the motor 90 and the HV wall 93. On the opposite side of the HV wall 93, the cartridge 50 may be positioned when attached to the chamber 27 of the housing 10. In some aspects, when the cartridge 50 is as Figure 3 During positioning, a plunger, piston, or other component within the syringe 70 of cartridge 50 can be advanced by piston 94 through HV wall 93 to propel the contents of cartridge 50 through nozzle assembly 60. In some aspects, motor 90 may be positioned within portion 31 adjacent to user interface 87. In some aspects, motor 90 may be a stepper motor, worm gear drive motor, solenoid, etc. The speed of motor 90 may be adjusted based on aspects such as the preferred flow rate of a particular liquid solution emitted by nozzle assembly 60 of cartridge 50.

[0159] like Figure 3As shown, housing 10 may include voltage lines 92c that contact the voltage contacts 92e of HV module 86 and the box voltage contacts 92a of HV wall 93. When assembled in chamber 27 of housing 10, box 50 is connected via box HV contacts 46 (see box HV contact 46). Figure 4B , 5A 5B) is electrically connected to voltage contact 92a. In operation, line 92c provides an electrical connection between the voltage supply of the high-voltage module 86 powered by battery B. Within portion 32 of housing 20 (e.g., below chamber 27), air pump 83 is connected to the supply end of air supply tube 81. When housing 50 is assembled with chamber 27, air supply tube 81 further supplies air to air supply tube 76 of housing 50 to provide air for spraying electrostatically charged droplets. The air supply of air pump 83 can provide a high-speed air supply without a separate air hose. In other embodiments, housing 10 may be connected to an external air hose that provides the air supply for spraying.

[0160] The applicator 100 may include a display screen with its user interface 87, which may include a liquid crystal (LCD) and / or a light-emitting diode (LED) display. The display screen of the user interface 87 allows the operator of the applicator 100 to receive information related to the status of the applicator 100, including operating parameters of the cartridge 50. For example, the display screen of the user interface 87 may display information related to the type of liquid solution within the disposable cartridge 50 connected to the applicator 100. As described above, this information may be written to the integrated memory of the disposable cartridge 50, and the CPU of the applicator 100 may receive and display this information to the operator of the applicator 100. In some aspects, the user interface 87 may display a welcome animation, indicate whether the electrostatic applicator has been connected to the user device (as described below), indicate whether the applicator 100 has been properly grounded, indicate whether the disposable cartridge 50 has been loaded into the cartridge chamber 27, and indicate what parameters are used for a particular liquid solution (e.g., flow rate, voltage supply, droplet size, expected target, expected patient condition, recommended proximity, etc.).

[0161] In some examples, the display of user interface 87 may also have touchscreen capability. For example, user interface 87 may act as an actuator to initiate or otherwise control the voltage supply to voltage line 92d of cartridge 50, initiate or otherwise control the airflow into air supply line 76, and / or initiate or otherwise control the plunger 71 of syringe 70 to expel fluid from syringe 70 through nozzle assembly 60. Other actuation mechanisms may be used for the sprayed fluid, including actuator 35 (e.g., mechanical triggers, switches, actuators, and / or graphical user interfaces configured to receive input from the user and perform one or more related operations) and / or signals from external user devices.

[0162] refer to Figure 4A It provides a front perspective view of box 50, while Figure 4B A rear perspective view of box 50 is depicted. Similarly, Figure 5A The lower rear perspective view of box 50 is depicted. Figure 5B A side view of the box, depicting a portion of its outer casing 49 removed, is shown. Figure 5C An exploded perspective view depicts the internal components of the box 50 with the outer shell 49 removed. Figure 5B A detailed view of the nozzle housing 60a is also shown. It should be understood that in some aspects, the entire housing 60a may be molded (e.g., insert molding) as a single integrally formed part and / or formed from multiple parts or segments. The nozzle housing 60a may include a nozzle outlet passage 62 at its distal end, which may be funnel-shaped, sized, and positioned to receive the outlet end of the delivery tube 61. The nozzle housing 60a may include an air inlet 66 in fluid communication with the nozzle end of the air supply tube 76 and the inlet 59 of the housing 50.

[0163] The nozzle housing 60a may include a voltage cavity port 69 for connecting a voltage line 92d and a corresponding voltage tube 92 to a delivery tube 61. One side of port 69 (e.g., the distal end of port 69) may include a contact section through which the line 92d can pass to contact the delivery tube 61. At the other end of port 69 (e.g., the proximal end of port 69), the cavity associated with port 69 may be tubular for frictionally securing the outer surface of the voltage tube 92. The nozzle outlet passage of the housing 60a may be positioned at the distal end of the housing 60a and may receive air from port 66 and the fluid delivery tube 61 and discharge droplets charged by the voltage line 92d. In some aspects, the line 92d may electrostatically charge the contents within the delivery tube 61 and the fluid contents proximal to it (e.g., the contents within the cylindrical portion 72 of the syringe 70). Figure 5B and Figure 5C As shown, voltage line 92d may include one or more curved surfaces (e.g., at least one downward angled bend to connect through tube 92, port 69, and contact delivery tube 61). Line 92d may include any number of shapes, including but not limited to S-shaped or serpentine shapes. To facilitate the shape of line 92d, tube 92 may include one or more curves or bends, as shown.

[0164] The housing 49 may be formed of a multi-part shell having an alignment groove 55 that engages with an alignment tab 25 of the cartridge chamber 27. The housing 49 may be formed and / or assembled in a variety of ways, including but not limited to machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Suitable materials for the housing 49 may include one or more of glass-filled nylon, glass-filled polypropylene, glass-filled polyethylene, polypropylene, polyethylene, or plastic materials. In some examples, the housing 49 may include two or more moldable plastic segments, such as a first half and a second half. The segments of the housing 49 may be assembled together by fasteners (e.g., screws, rivets, welding [e.g., acoustic welding], one or more straps or snaps, adhesives or adhesive tape, etc.) such that internal components are disposed between portions and / or corresponding halves of the housing 49. In some aspects, the housing 49 may include a housing spray outlet associated with the nozzle assembly 60, which allows an electrified treatment solution to be discharged from the cartridge 50.

[0165] The recess 55 can engage with the tab 25 to align the housing with the cartridge chamber 27, ensuring proper alignment between the cartridge 50 and the chamber 27. The housing 49 may include a recess 55 positioned on opposite lateral sides of the cartridge 50. The recess 55 may include an open proximal end 55p and a closed distal end 55d. When the distal end 55d of the recess 55 is adjacent to or otherwise toward the nozzle assembly 60, the distal end 55d prevents the tab 25 from sliding deeper into the recess 55. In some aspects, the proximal end 55p may be the opposite distal end 55d and may include an open, funnel-shaped, or tapered shape to facilitate alignment and engagement between the recess 55 and the tab 25.

[0166] Figure 4B Specifically, the supply end and contact end of the housing 50 are shown. The HV contact 46 may be a contact port embedded in and / or otherwise positioned on the surface of the housing HV wall 54, configured to abut against the HV wall 93 of the housing 10. The HV wall 54 may also include an air inlet 47, which may be configured to engage with a corresponding air inlet 147 of the HV wall 93 (see, for example...). Figure 7A and 7B ).like Figure 3 and Figure 5AAs shown, the housing 50 may also include an air supply port 59 configured to receive an air supply tube 81 to provide fluid communication between the tubes 81, 76, and the pump 83. The air supply port 59 may be positioned on a stepped portion of the housing 49, the stepped portion being shaped to correspondingly attach to a stepped portion 29 of the housing 49. The supply port 59 of the air supply tube 81 may extend at least partially from the housing 49 and is shaped to insert at or near the stepped portion 29 into an air supply port 29a on the applicator housing 10. In some aspects, the air supply tube 76 of the housing 50 and the air supply tube 81 of the housing 10 may comprise a combination of both flexible and rigid materials (e.g., nylon braiding). In some aspects, the air supply tube 76 of the housing 50 and the air supply tube 81 of the housing 10 may be made of a flexible, fluid-impermeable material (such as an elastomer, rubber, silicone, polyvinyl chloride, etc.). In some aspects, the air supply pipe 76 of the housing 50 and the air supply pipe 81 of the housing 10 may also be inserted into the molding and / or overmolded using a combination of softer, flexible, impermeable materials and / or one or more rigid materials (e.g., metals, alloys, etc.).

[0167] Once securely engaged with chamber 27, box 50 can be released via release button 57. Figure 5A , 5B and Figure 6 As shown, button 57 may extend at least partially through the lower surface 53 of housing 49 via an aperture in the lower surface 53 of housing 49. Button 57 may be a latch attached to, for example, a portion of syringe 70 and removable from cartridge 50 when it is ready to be attached to housing 10. This may indicate to the user that cartridge 50 has not been used and its contents (e.g., liquid therapeutic solution) have not been used. In some examples, the contents stored within syringe 70 may be sterilized, and releasing button 57 may indicate that the contents of disposable cartridge 50 are sterile and have not been used (e.g., not used on a previous patient). In some aspects, button 57 may prevent syringe 70 and any of its components from advancing the contents therein before use. In some aspects, button 57 may include a near field communication (NFC) tag having identification cartridge information and other operating parameters that can be read from it, thereby indicating to the user that cartridge 50 has not been used and its contents (e.g., liquid therapeutic solution) have not been used.

[0168] For example Figure 5A , 5B and Figure 6As shown, the cartridge 50 may contain and / or at least partially surround the aforementioned air supply tube 76, voltage tube 92, and syringe 70 within its housing 49. The syringe 70 may be an assembly including a glass or plastic syringe for storing a liquid solution to be applied using the disposable cartridge 50. The syringe 70 may be assembled within the disposable cartridge 50 pre-filled with the desired liquid solution. Proximally, the syringe 70 may include a movable plunger 71, a movable stopper 71a, and a barrel portion 72 extending distally therefrom. The plunger 71 and stopper 71a are configured to advance within the barrel 72 such that the contents of the barrel portion 72 are advanced through a Luer lock 74 located distally at the portion 72. An internal distal delivery tube 61 may extend distally from the Luer lock 74 through the nozzle assembly 60. The delivery tube 61 may be substantially tubular with a blunt distal tip. However, the delivery tube 61 is not limited thereto and may include a puncture tip. The delivery tube 61 can preferably be in the range of about 15 gauge (0.072 inches outer diameter and 0.054 inches inner diameter) to about 30 gauge (0.01225 inches outer diameter and 0.00625 inches inner diameter). At the distal end of the Luer lock 74, the distal end of the voltage line 92d can pass through the nozzle tube 92 and connect to the proximal portion of the internal distal delivery tube 61, which can be constructed of one or more conductive materials. The line 92d can include a needle-like structure made of one or more conductive materials (e.g., metal) that can generate an electric field to charge the liquid solution flowing from the syringe 70 through the nozzle assembly 60. In operation, the syringe 70 can be configured to deliver the stored liquid solution from the barrel portion 72 through the delivery tube 61 at a predetermined rate and ultimately spray it onto the treatment site (e.g., a patient's wound site) via the nozzle assembly 60.

[0169] In some aspects, voltage line 92d may be electrically connected to a voltage source at one end (e.g., port 46) and to a nozzle tube (e.g., nozzle tube 92d) at the nozzle end, such as... Figure 5B and 5C As shown in the diagram. Although not shown, it is conceivable that in some aspects, contact 46 may be in direct electrical communication with multiple aspects of syringe 70 (e.g., directly connected to plunger 71), rather than having line 92d extend from port 46 to tube 61. Voltage line 92d may be substantially axially aligned along syringe 70 within disposable cartridge 50. Nozzle tube 92 may be positioned such that the nozzle end of line 92d may electrostatically charge the contents of syringe 70 prior to delivery from nozzle assembly 60 (e.g., by contacting delivery tube 61 as it exits Luer lock 74 distally). For example, as Figure 5BAs shown, the distal end of the delivery tube 61 through the Luer lock 74 is electrically connected to the distal end of the line 92d, while the opposite end (contact 46) of the voltage line 92d is electrically connected to the contact 92a, line 92c, and port 92e of the HV module 86. In some aspects, a loop or hook of the line 92d may contact the delivery tube 61. In some aspects, the loop or hook of the line 92d may comprise one or more conductive materials, such as copper, steel, or any other metal alloy. In some aspects, the inner diameter of the loop or hook of the line 92d may be configured to allow contact with the delivery tube 61. In some aspects, the voltage line 92d may be attached (e.g., spotwelded, crimped, etc.) in place and then encapsulated with a high-dielectric adhesive. The loop or hook of the line 92d may at least partially surround the outer surface of the delivery tube 61 to provide it with a voltage potential.

[0170] In some examples, the NFC tag of the disposable cartridge 50 and / or other internal memory of the cartridge 50 may include additional information about the contents stored therein (e.g., liquid therapeutic solution, recommended operating parameters, tracking information, expiration date, etc.). This information may be used by, for example, the applicator 100 to monitor the type of contents, its volume, and to modify the voltage, flow rate, recommended travel distance (i.e., proximity), etc., for a particular solution. In some examples, this information may be stored on an integrated memory, which may include, but is not limited to, RAM, ROM, EPROM, EEPROM, etc. The information on the integrated memory 120 may be relayed to the applicator 100 via the integrated memory and / or the NFC tag, and this information may be used to adjust or otherwise control aspects of the cartridge (e.g., components of the syringe 70 (e.g., stop 71a), flow rate, air intake from the pump 83, voltage applied to the delivery tube 61 by the line 92d, etc.). In some aspects, one or more processors of the applicator 100 may be configured to read information from an NFC tag or other internal memory of the cartridge 50 in relation to operating parameters of the cartridge 50; and to display the read NFC information (e.g., information such as identification of the contents of the cartridge 50, volume information, etc.) on a display screen. In some aspects, operating information may be written to the NFC by a processor of the electrostatic applicator system.

[0171] The distal end of tube 92 may be configured to be physically connected to port 69 of nozzle assembly 60. Similarly, air supply tube 76 may extend from cartridge air port 59 to nozzle air port 66 of nozzle assembly 60. Tube 76 may provide high-speed air to spray the contents of cartridge 50 (e.g., contents disposed in syringe 70) onto the treatment site. The distal end of tube 76 may be an outlet of air supply tube 76 via port 66 for providing high-speed airflow to nozzle assembly 60.

[0172] In some aspects, one or more accumulators (not shown) may be positioned within the disposable cartridge 50 or housing, whereby the one or more accumulators are configured to receive, store, and release energy during operation of the disposable cartridge 50. Examples of one or more accumulators contemplated for use with the disposable cartridge 50 may include one or more springs, flywheel energy storage mechanisms, batteries, capacitors, etc.

[0173] Go to Figure 6 A spring 106 (e.g., a disposable latching spring) may communicate with the housing side of the button 57. In operation, the spring 106 may provide a spring bias to the button 57, which holds the button 57 in the closed position, as in... Figure 6 The one shown Figure 3 A close-up cross-sectional view of section 6 is shown. In some respects, Figure 6 The button 57, with spring 106 arranged in the middle, can be a movable hinge configured to hold the button 57 in the closed, retaining position shown. A solenoid 115 can be provided within the housing side of the housing 10. Figure 6 The image depicts the solenoid 115 in a non-energized position. A solenoid plunger 117 is disposed within the solenoid 115 and may include a return spring. A solenoid plunger tip 113 may be disposed at the distal end of the plunger 117. As can also be seen, a rigid housing catch 109 is provided to retain the button 57 in a closed configuration having the solenoid 115, including the plunger 117 and the tip 113. Figure 6 The example shown is merely one way to set up an easy and secure connection and separation between the cartridge 50 and the housing 10 of the applicator 100; other connection methods can be envisioned for use with the disposable cartridge 50 of this disclosure.

[0174] Figure 7A A close-up cross-sectional view of an example aspect of the HV wall 93 is depicted when the box 50 is not connected to the housing 10. Figure 7B An example aspect of the HV wall 93 is shown when the box 50 is connected to the housing 10. Figure 7A In this configuration, the HV wall 93 is closed relative to the housing 10 in all aspects of air intake and exhaust. Specifically, port 147 may include an air path opening through the HV wall 93 and ultimately to port 47 of the housing 50. Although the associated tubing for port 147 is not shown, it will be provided between port 147 and pump 83 during use. Port 147 may include a true valve seal housing in which the intake port 93a of the HV wall 93 may be nested. In some aspects, the valve seal conical spring may have been positioned to retrain the corresponding valve seal 143 in the sealed closed position, such as... Figure 7A As shown. In Figure 7BIn the diagram, housing 50 is shown attached to HV wall 93. Specifically, port 47 of housing 50 is shown inserted into port 93a, thereby pushing seal 143 into an open configuration. Air can then pass through seal 143 and enter housing 50.

[0175] Figure 8A Depicting the previous Figures 1A to 3 The diagram shows a side cross-sectional view of an example aspect of the actuator 35. Specifically, the actuator 35 may include a switch base 35a configured to be directly coupled to various aspects of the housing 10. In some aspects, the base 35a may be coupled to a flexible boot 35f and may be directly coupled to a switch cap 35c. One or more switch contacts 35b may be positioned in the base 35a and communicate with a switch return spring 35d and a switch short-circuit contact 35e. In some aspects, the actuator 35 may be configured to resist high pressure and heavy water jets (e.g., IP6X water ingress rating). In some aspects, the flexible boot 35f is configured to surround the components of the actuator 35 and allow movement while maintaining a seal.

[0176] Figure 8B It describes what was previously intended to be used with Figures 1A to 3 A side cross-sectional view of another example actuator 35' used in conjunction with the example, wherein the previous flexible shield 35f has been replaced by a flexible internal bellows boot 35' positioned inside the switch cap 35c and directly coupled to the base 35a. In some aspects, the flexible internal bellows boot 35' is configured to surround the return spring 35d and the contact 35e to resist high pressure and heavy water spray (e.g., IP6X water and dust intrusion rating).

[0177] refer to Figure 9A A front perspective view of the box 250 constructed for electrospinning is provided, while Figure 9B A rear perspective view of cartridge 250 is depicted. Aspects of cartridge 250 include the same reference numerals as those in cartridge 50, indicating the same structural elements and features. In some aspects, the nozzle 260 of cartridge 250 is configured to receive source liquid from syringe 270 and to feed highly compressed air via one or more injection holes 267, such that the source liquid for fibers in syringe 270 can be injected together with air and a voltage applied thereto to generate and eject electrospun fibers with a fine diameter. In some aspects, the holes 267 may be arranged radially around tube 261 and formed in... Figure 9BThe supply end and contact end of the housing 250 are specifically shown. HV contact 246 is positioned on the mounting surface of the housing HV wall 254, configured to abut against the HV wall 93 of the housing 10. The HV wall 254 may also include an air inlet 247, which may be configured to connect to a corresponding air inlet 147 on the HV wall 93 (see example...). Figure 7A and 7B ).

[0178] Similarly, Figure 10A A lower rear perspective view of box 250 is depicted. Figure 10B A side view of the box 250 with a portion of its outer casing 249 removed is depicted. Figure 10C An exploded perspective view depicts the internal components of the box 250 with the outer shell 249 removed. Similar to the housing 49, the housing 249 can be formed and / or assembled in a variety of ways, including but not limited to machining, molding, injection molding, 3D printing, or any other suitable manufacturing process. Materials suitable for the housing 249 may include one or more of glass-filled nylon, glass-filled polypropylene, glass-filled polyethylene, polypropylene, polyethylene, or other plastic materials.

[0179] like Figure 9A , Figure 10B and Figure 10C As shown, the nozzle assembly 260 may include a nozzle housing 260a. The housing 260a may include a nozzle outlet channel 262 at its distal end, which may include the outlet end of the delivery tube 261. The nozzle housing 260a may include an air inlet port 266 in fluid communication with an orifice 267 positioned around the channel 262. Figure 9A As shown, housing 260a may include six (6) holes arranged radially around a common axis of channel 262, but fewer or more holes may be used as needed or required. In some aspects, holes 267 may be replaced by an external concentric outlet channel that completely surrounds channel 262 and is similarly in fluid communication with port 266. During use, air pumped from port 266 and pumped out through the multiple holes 267 can create an air curtain surrounding the electrospun fibers emitted from tube 261. Figure 9A In the illustrated examples, the aperture 267 is shaped to be substantially straight or otherwise angled parallel to and / or axially aligned with the tube 261, such that the corresponding air curtain is similarly parallel and / or axially aligned. In other examples, the aperture 267 is shaped to be angled upward relative to the longitudinal axis of the tube 261 to create a funnel-shaped, tapered, outward air curtain. In still other examples, the aperture 267 is shaped to be angled downward relative to the longitudinal axis of the tube 261 to create a converging, tapered, inward-facing air curtain.

[0180] In some examples, housing 249 may comprise two or more segments of moldable plastic, such as a first half and a second half (which, when assembled together, will be referred to herein as housing 249). These two or more segments may be assembled together using fasteners (e.g., screws, rivets, welding [e.g., acoustic welding], one or more straps or snaps, adhesives or adhesive tapes, etc.) such that internal components are positioned between portions and / or corresponding halves of housing 249. In some aspects, housing 249 may include an optical fiber outlet associated with nozzle assembly 260, which allows atomized, electrostatically charged treatment solution to exit from cartridge 250. Port 247 is configured to receive air supply conduit 81, allowing conduits 81, 76 and pump 83 to be in fluid communication with each other.

[0181] Like cartridge 50, cartridge 250 can be securely engaged with chamber 27. Although not shown, cartridge 250 may contain an air supply tube, a voltage tube, and syringe 270 within its housing 249. Similar to syringe 270, syringe 270 may be an assembly including a glass or plastic syringe for storing a liquid solution to be applied using disposable cartridge 250. Syringe 270 may be assembled within disposable cartridge 250 pre-filled with the desired liquid solution. Proximally, syringe 270 may include a plunger and a barrel portion 272 extending distally from the plunger. The contents of syringe 270 may be propelled through a Luer lock 274 located distally at portion 272. An internal distal delivery tube 261 may extend distally from Luer lock 274 through nozzle assembly 260. At the distal end of the Luer lock 274, the distal end of a voltage line (not shown, though similar to line 92d of cartridge 50) passes through the nozzle tube of cartridge 250 and connects to the proximal portion of an internal distal delivery tube 261, which may be constructed of one or more conductive materials. In operation, syringe 270 may be configured to deliver electrospun fibers from a stored liquid solution from the barrel portion 272 through the delivery tube 261 at a predetermined rate and ultimately eject them via the nozzle assembly 260 to a treatment site (e.g., a patient's wound site).

[0182] In some examples, the aforementioned NFC tag of the disposable cartridge 250 and / or other internal memory of the cartridge 250 may include additional information about the contents stored therein (e.g., a liquid therapeutic solution). This information may be used by, for example, the applicator 100 to monitor the type of contents, its volume, and to modify the voltage, flow rate, recommended travel distance (i.e., proximity), etc., for a particular solution. In some examples, this information may be stored on an integrated memory, which may include, but is not limited to, RAM, ROM, EPROM, EEPROM, etc. Information on the integrated memory 120 may be relayed to the applicator 100 via the integrated memory and / or the NFC tag, and this information may be used to adjust or otherwise control aspects of the cartridge (e.g., components of the syringe 270).

[0183] Figure 11A Depicting the idea of ​​using with Figures 1A to 3 A perspective view of the internal components of another example electrostatic box 350 used in conjunction with the example electrostatic applicator, which includes a pair of syringes and an electrostatic nozzle. Figure 11B Depicting Figure 11A The example internal components are shown in a side cross-sectional view. For illustrative purposes, the outer shell of box 350 is not shown. Figure 11A and Figure 11B Strictly illustrated. In contrast to the previously described cartridges 50 and 250, cartridge 350 may contain a multi-plunger injector 370 within its housing, whereby each sub-injector of the multi-plunger injector 370 may include its own air supply tube, voltage tube 392, barrel 372, stop 371a, and injector actuation shaft 371. The actuation shaft 371 of the multi-plunger injector 370 may be proximally connected via a central drive surface 371b, such that the propulsion surface 371b causes each connected actuation shaft 371 to simultaneously advance the corresponding stop 371a to distally push the contents stored in the corresponding portion 372 through the corresponding Luer lock 374 and ultimately into the corresponding nozzle assembly 360. In some aspects, Figure 11A and 11B The example voltage transistor 392 and the corresponding voltage line (not shown) depicted may include a separate and independent high-voltage input. In some aspects, Figure 11A and Figure 11B An example configuration is to increase the generation of deliverable therapeutic solutions (e.g., electrospray contents, electrospun fibers, etc.) from it, and to cover a larger area more quickly via multiple nozzle assemblies, wherein the high voltages are separate and the fluid paths are always independent, as shown. In some aspects, the syringe 370 can be configured such that the sub-assemblies are dispensed at a ratio other than 1:1. Although in Figure 11A and 11BOnly two sub-components are shown, but it is conceivable that more than two sub-components can be used as needed or required.

[0184] Figure 12A Depicting the intended use with Figures 1A to 3 A perspective view of the internal components of another example electrostatic box 450 used in conjunction with the example electrostatic applicator, which includes a pair of syringes and an electrostatic nozzle. Figure 12B Depicting Figure 12A The example shown is a side cross-sectional view of the internal components. For illustrative purposes, the housing of box 450 is not shown. Figure 12A and 12B It is strictly shown in the text. In some respects, Figure 12A and Figure 12B Example configurations of the syringe 470 include increased production of deliverable therapeutic solutions (e.g., electrospray contents, electrospun fibers, etc.) and faster coverage of larger areas via multiple nozzle assemblies, wherein high voltages are separate and the fluid paths are always independent, as shown. In some aspects, the first sub-assembly of the syringe 470 may include a rod 471, a stop 471a, a barrel portion 472, a Luer lock 474, and a nozzle assembly 460, all configured for electrospraying. In some aspects, the second sub-assembly of the syringe 470 may include a rod 471', a stop 471a', a barrel portion 472', a Luer lock 474', and an electrospinning tube 461', all configured for electrospinning. In some aspects, the syringe 470 may be configured such that the sub-assemblies are dispensed at a ratio other than 1:1. In some aspects, the use of each of the first and second sub-assemblies of the syringe 470 is advantageous for both electrospraying and electrospinning using a single cartridge. In some respects, the cylinder portions 472 and 472' can be configured to contain fluid solutions of different volumes and / or types.

[0185] Contrary to the previously described cartridges 50 and 250, cartridge 450 may contain a multi-plunger injector 470 within its housing, whereby each sub-injector of the multi-plunger injector 470 may include its own air supply tube, voltage tube 492, barrel portions 472, 472', stops 471a, 471a', and injector rods 471, 471'. The shafts 471, 471' of the multi-plunger injector 470 may be connected proximally via a central drive surface 471b, such that the propulsion surface 471b causes each connecting rod 471, 471' to simultaneously advance the corresponding stops 471a, 471a', thereby distally propelling the contents stored in the corresponding portions 472, 472' through the corresponding Luer locks 474, 474' and ultimately into the corresponding nozzle assembly. In some aspects, Figure 12A and 12BThe example voltage transistor 492 and corresponding voltage lines (not shown) depicted may include separate and independent high-voltage input terminals. Although in Figure 12A and 12B Only two sub-components are shown in the image, but it is conceivable that more than two sub-components can be used as needed or required.

[0186] Figure 13A Depicting what is considered for use with Figures 1A to 3 A perspective view of the internal components of another example electrostatic box 550 used in conjunction with the example electrostatic applicator, which includes a pair of syringes and an electrostatic nozzle. Figure 13B Depicting Figure 13A The example shown is a side cross-sectional view of the internal components. The housing of box 550 is not in... Figure 13A and Figure 13B The internal components are shown strictly for illustrative purposes to observe them. Unlike the previously described cartridges 50 and 250, cartridge 550 may contain a multi-plunger injector 570 within its housing, whereby each sub-injector of the multi-plunger injector 570 may include its own air supply tube, voltage tube 592, barrel portion 572, stop 571a, and injector rod 571. The actuation shaft 571 of the multi-plunger injector 570 may be connected proximally via a central drive surface 571b, such that the propulsion surface 571b causes each connecting rod 571 to simultaneously advance its corresponding stop 571a, thereby pushing distally the contents stored in the corresponding portion 572 through the corresponding Luer lock 574 and ultimately into the corresponding nozzle assembly 560.

[0187] exist Figure 13A and Figure 13B In the example, each barrel portion 572 and its corresponding sub-assembly structure can be interconnected via a Y-shaped delivery needle 561. The tube 561, as shown, may include a proximal port in fluid communication with each Luer lock 574 and barrel portion 572, and is coupled to a single distal end via solution, which can be ejected or otherwise exited. A voltage tube 592 and a corresponding voltage line (not shown) may be coupled to the delivery tube 561 at the proximal end of the distal end of the tube 561, such that all solution ejected from it is charged by the voltage line. Although a Y-shaped component is shown, any number of syringe sub-assemblies can be used with the cartridge 550 upon request. In some aspects, Figure 13A and 13B The voltage transistor 592 and the corresponding voltage line (not shown) illustrated in the example may include a separate and independent high-voltage input. In some aspects, Figure 13A and 13BExample configurations include increasing the generation of deliverable therapeutic solutions (e.g., electrospray contents, electrospun fibers, etc.) from it, and more quickly covering larger areas via multiple nozzle assemblies, wherein the high voltages are separate and the through-fluid paths, as shown, are always independent. In some aspects, syringe 570 can be configured such that the sub-assemblies are dispensed at a ratio other than 1:1. Although in Figure 13A and Figure 13B Only two sub-components are shown, but it can be expected that more than two sub-components can be used as needed or required.

[0188] Figure 14A A side perspective view of example cones 607, 603 is shown, configured for use with any nozzle assembly disclosed herein of the described disposable cartridge. In some aspects, cone 603 may be a physical cone of any material attached to a distal end of a nozzle assembly or directly attached to housing 10. In some aspects, cone 607 may be directly attached to a distal end of a delivery tube associated with a respective nozzle assembly. In some aspects, cone 603 may be configured to protect electrospray or electrospinning material from the respective system (e.g., applicator 100 and any disposable cartridge attached thereto) to a treatment site (e.g., a patient's wound site) by preventing external airflow and / or external force interference. In some aspects, cone 603 may be configured to control airflow in the respective nozzle assembly by reflecting the spray from its cone walls. In some aspects, once attached to housing 10 and / or the corresponding nozzle assembly, cone 603 can be configured such that one or more lamps (e.g., LEDs) can generate a light pattern (e.g., a halo) on the target site from the proximal end of the annular cone of the electrostatic applicator and via a photopipe effect to aid in targeting. In some aspects, if a translucent material is used with cone 603, the cone can disperse light, including different colors, from applicator 100 to notify the user of the appropriate distance by warning whether the applicator is too close or too far.

[0189] Figure 14B A side perspective view of another example cone 703 is depicted, configured for use with any nozzle assembly disclosed herein of the described disposable cartridge. In some aspects, cone 703 may be a physical cone of any material attached to the distal end of the nozzle assembly or directly attached to housing 10. Similarly, cone 703 may be illuminated when a solution is emitted from it. For example, the inner surface 709 of cone 703 may be configured to be illuminated and plated or polished with a non-stick surface.

[0190] Figure 14CA side perspective view of another example cone 803 is depicted, configured for use with any nozzle assembly disclosed herein of the disposable cartridge. In some aspects, cone 803 may be a physical cone of any material attached to the distal end of the nozzle assembly or directly attached to housing 10. In some aspects, the inner surface 809 of cone 803 may be plated or polished with a conductive surface that may have the same polarity as the fluid being dispensed, which will aid in dispensing direction. The distal edge 808 of cone 803 may be left without the same conductive surface plated and / or polished.

[0191] Figure 14D A side perspective view of another example cone 903 is depicted, configured for use with any nozzle assembly disclosed herein of the disposable cartridge. In some aspects, the cone 903 may be a physical cone of any material attached to the distal end of the nozzle assembly or directly attached to the housing 10. In some aspects, the inner surface 909 of the cone 903 may be electroplated or polished with multiple conductive surfaces (e.g., radially separating surfaces that may be electrostatically charged to repel and / or attract solution and change the dispensing direction).

[0192] Figure 15-17 This is a component diagram of various parts and systems that may be included in an electrostatic applicator system (e.g., within applicator 100 and / or any disposable cartridges 50, 250, 350, 450, 550) according to this disclosure. A controller 1500, which may include a CPU, may communicate with various parts and systems to operate the electrostatic applicator. For example, controller 1500 may communicate with the disposable cartridge to receive information about a specific fluid contained within the cartridge. This information conveyed to controller 1500 (e.g., via integrated memory) may include information about preferred fluid flow rates (e.g., by adjusting motor speed), air supply rates, voltage (e.g., by adjusting the voltage potential between the voltage supply (e.g., HV module 86) and the delivery tube of the corresponding nozzle assembly of the respective cartridge), etc., such that preferred nanoparticles may be formed from the sprayed therapeutic solution. This information enables a single reusable applicator 100 to be used with many different disposable cartridges 50, 250, 350, 450, 550 with different solutions. Furthermore, not only may the fluid in each of the disposable cartridges 50, 250, 350, 450, and 550 differ, but depending on the specific application of each cartridge, different cartridges may have different air supply lines, voltage lines, and / or nozzle assemblies. For this purpose, this component information can also be relayed to the controller 1500, allowing the reusable applicator 100 to be adjusted accordingly.

[0193] The controller 1500 can communicate with a sensor subsystem 1502, which includes various sensors that can be used to operate the reusable applicator 100. The sensor subsystem 1502 may include an accelerometer 1504, which can be used to wake up the CPU when the user moves the reusable applicator 100. For example, in addition to or as an alternative to any button or capacitive input from the associated user interface described above, the reusable applicator 100 may be automatically activated (e.g., the CPU may receive power) when the accelerometer detects movement of the reusable electrostatic applicator. The sensor subsystem 1502 may include a burst detection 1506 located near the cartridge chamber 27 to determine whether the cartridge is adequately attached to the chamber 27. The burst detection 1506 may serve as a safety measure to ensure that disposable cartridges 50, 250, 350, 450, and 550 are fully seated within the chamber 27 before the applicator 100 can be activated. The burst detection 1506 may be a pressure sensor, a switch, etc.

[0194] The sensor subsystem 1502 may include a proximity sensor 1508 to detect the proximity of the reusable applicator 100 to the treatment or target site. The proximity sensor 1508 may be located at the distal end of the reusable applicator 100, for example, near or adjacent to the spray outlet of the corresponding cartridge 50, 250, 350, 450, 550. Alternatively, the proximity sensor 1508 may be located on, near, or adjacent to the housing spray outlet of the corresponding disposable cartridge 50, 250, 350, 450, 550. The proximity sensor 1508 may include, but is not limited to, inductive proximity sensors, capacitive proximity sensors, photoelectric proximity sensors, etc. The proximity sensor 1508 may be a safety feature for instructing an operator whether the electrostatic applicator is within a preferred distance from the target object (e.g., configured to detect the proximity between the electrostatic applicator and the target). For example, the travel distance of a charged droplet can affect the droplet's morphology upon contact with the target site. For this purpose, proximity sensor 1508 can send a signal to controller 1500 to indicate the distance to the target object, and controller 1500 can output a signal to user interface 1536 (e.g., display screen, external user device, etc.) to warn the user that the device is too far away or too close to the target area. As described above, this information can be based on information stored in the integrated memory of disposable cartridges 50, 250, 350, 450, and 550.

[0195] Sensor subsystem 1502 may include gyroscope 1510, which can be used to help measure or maintain a specific position of the reusable applicator 100. For example, gyroscope 1510 may output a signal to user interface 1536 (e.g., display screen, external user device, etc.) to indicate to the user that the device should be moved to an upright configuration or any other configuration. Sensor subsystem 1502 may also include the aforementioned handle ground 1426. In addition to grounding the operator, handle ground 1426 can be used to detect whether the user is holding the device and whether the device should be activated.

[0196] The controller 1500 can communicate with a control subsystem 1514, which includes various sensors, switches, etc., to ensure that the reusable applicator 100 operates as intended. The control subsystem 1514 may include a cartridge temperature sensor 1516. While disposable cartridges 50, 250, 350, 450, and 550 are intended to be stored and used at room temperature, they can also be stored under other conditions, such as frozen, to preserve the treatment solution stored within. The cartridge temperature sensor 1516 can detect the temperature of the treatment solution and alert the user if the solution is too cold or too hot to be applied to the patient's skin.

[0197] Control subsystem 1514 may include pressure sensor 1518, which is configured to read the air pressure of the airflow entering the respective cartridge (e.g., the air supply associated with pump 83) through an air supply source. This pressure information may be used by controller 1500 to determine whether the airflow through the device is providing a preferred air velocity for a specific sprayed fluid. Control subsystem 1514 may include flow meter 1520, which is configured to read the fluid velocity of the fluid traveling through or exiting the nozzles of the respective cartridges 50, 250, 350, 450, 550. This velocity information may be used by controller 1500 to determine whether the fluid flow through the device is providing a fluid volume for a specific sprayed solution.

[0198] The control subsystem 1514 may include a motor limit switch 1522. The motor limit switch 1522 can be used to limit the rate at which the piston of the applicator is actuated, to further limit and / or modulate the flow rate of the treatment solution. The control subsystem 1514 may include a voltmeter 524. The voltmeter 524 can be used to determine what voltage is applied at the nozzle tube 106. If the voltage is cut off for any reason related to the specific fluid, an alarm can be sent to the user interface 1536 (e.g., the display of the user interface 87, an external user device, etc.).

[0199] In some aspects, the control subsystem 1514 may include or communicate with a cartridge detection switch configured to detect the presence of a cartridge when assembled with an electrostatic applicator. If presence is detected, one or more operations associated with the corresponding cartridge may be performed or otherwise initiated. In some aspects, the control subsystem 1514 may include or communicate with an NFC chip of the disposable cartridge, whereby the NFC chip may include integrated memory having information relating to the characteristics (e.g., treatment solution) of the contents stored within the cartridge and / or the syringe within the cartridge, including operational parameters of the cartridge contents such as whether the cartridge is sealed or unsealed, flow rate, voltage potential, and / or nozzle settings associated with the nozzle, in order to adjust motor speed or the voltage applied to these contents for deposition from the cartridge and / or the electrostatic applicator to the treatment site.

[0200] The controller 1500 can also receive a signal indicating whether grounding strip 424 has been applied to the external ground (e.g., the wound site of the patient and / or target). If not, the controller 1500 can send an alarm to the user interface 1536 and / or disable activation of the reusable applicator 100 (e.g., by preventing electrical connection between the voltage supply of the HV module 86 and the corresponding nozzles of the respective cartridges 50, 250, 350, 450, 550, via a switch). The controller 1500 can also communicate with the charging system 1530. As described above, the voltage supply 420 may include one or more rechargeable batteries. The charging system 1530 may include an AC / DC converter and an inductive integrated circuit to manage charging of the rechargeable voltage supply of the HV module 86.

[0201] The controller 1500 can also communicate with the communication subsystem 1532. The communication subsystem 1532 may be integrated within the CPU and / or HV module 86 and includes one or more transceivers capable of communicating with external devices. The one or more transceivers may be compatible with short-range wireless communication connections, such as, but not limited to, radio frequency identification (RFID), near field communication (NFC), and Bluetooth. TM Low-energy Bluetooth TM (BLE), WiFi™, ZigBee™, and / or similar connections. The communication subsystem 1532 enables the reusable applicator 100 to communicate with external devices, such as user devices. User devices may include mobile cellular devices, personal digital assistants (PDAs), tablets, laptops or desktop computers, smart wearable devices, etc. In this example, the user device may operate similarly to a display screen to provide information to the device operator. For example, a display screen of the user device may be used in addition to or as an alternative to a display screen.

[0202] Wireless communication between the reusable applicator 100 and the user device provides the option to use the user device as an actuator to activate the spray sequence of the electrostatic applicator. For example, activation input to the controller 1500 (or CPU) may include providing input to a display screen on an external user device. Additionally, information related to the fluid within disposable cartridges 50, 250, 350, 450, and 550 can be input to the user device to inform the controller 1500 which spray parameters should be used for a particular cartridge. In some examples, barcodes, quick-response (QR) codes, etc., may be placed on disposable cartridges 50, 250, 350, 450, and 550. The user can scan the code using a camera or other scanner on the user device, and this information can be relayed to the controller 1500. The controller 1500 can then determine the necessary spray parameters for a particular cartridge. The user can then input activation input (e.g., pressing an icon on the user device's screen) to begin spraying the therapeutic solution.

[0203] Refer again Figure 15 The controller 1500 can communicate with the user interface 1536, which can provide information to and receive information from the operator of the reusable applicator 100. Figure 16 Detailed component diagrams of an example user interface 1536 are provided. User interface 1536 may include the display screen of the user interface 87 described above. For example, user interface 1536 may include an LCD / LED screen 1538 for providing the user with information about the status of the device.

[0204] In some examples, user interface 1536 may include a display touch panel 1540. In examples where user interface 1536 (e.g., existing user interface 87) is a display on reusable applicator 100, the display may include touchscreen capability. This allows the display to receive activation input to initiate a spray sequence from reusable applicator 100. For example, the display may provide an icon that can act as a virtual “actuator” to activate the spray sequence. Furthermore, information about the fluid contained in a particular disposable cartridge 50, 250, 350, 450, 550 may be input to the display touch panel 1540 to inform controller 1500 (or CPU) what parameters should be used for a particular treatment solution. User interface 1536 may include a buzzer 1542. Buzzer 1542 may include one or more speakers that can indicate to the operator whether a problem should be addressed with the device. For example, buzzer 1542 can provide audible feedback about a specific state if disposable boxes 50, 250, 350, 450, and 550 are not fully in place, if the ground of applicator 100 (e.g., grounding strip 1424 or handle grounding 1426) does not detect a proper ground, or if the voltage supply of HV module 86 is low or should be charged. Furthermore, the display of user interface 87 can also provide visual feedback to additionally alert the user to a specific problem. Alternatively or additionally, user interface 1536 may include a vibration motor 1544 that can indicate to the user, via tactile feedback, when a problem has occurred. User interface 1536 may include a start / stop button 1546. Alternatively, the start / stop button 1546 may be integrated into a display (e.g., the display of user interface 87 or a display on an external user device) so that activation of the device can be performed within a screen with touchscreen capability. User interface 1536 may include an actuator 1555 (e.g., a trigger). As described above, actuator 1555 may be an actuator, a virtual actuator within the user interface of an external user device, or a virtual actuator as an icon in the display screen of user interface 87.

[0205] Figure 17 This is a component diagram of an example controller 1500 according to the present disclosure. As described above, controller 1500 may include one or more processors, such as a CPU. The CPU may include one or more of a microprocessor, microcontroller, digital signal processor, coprocessor, etc., or a combination thereof, capable of executing stored instructions and manipulating data. The CPU may be configured as a single-core or multi-core processor that performs parallel processing simultaneously. For example, the CPU may be a single-core processor configured with virtual processing technology. The CPU may use a logic processor to execute and control multiple processes simultaneously.

[0206] Controller 1500 may include memory 1560. Memory 1560 may communicate with one or more processors (e.g., CPU). Memory 1560 may include instructions that cause the CPU and / or controller 1500 to perform any of the processes described herein, such as program 1580 or other applications. For example, memory 1560 may include instructions that cause controller 1500 and / or CPU to receive activation signals (e.g., from a manual trigger, from an external user device, from a display screen of user interface 87, etc.), output control signals (e.g., control signals to a motor and / or piston associated with actuating the pushing of solution from a corresponding cartridge through a corresponding nozzle) to actuate the delivery of fluid from syringes 70, 270, 370, 470, 570, and output control signals to switches to provide voltage from the voltage supply of HV module 86 to a corresponding voltage line (e.g., line 92d).

[0207] In some embodiments, memory 1560 may include one or more suitable types of memory (e.g., volatile or non-volatile memory, random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), disk, optical disk, floppy disk, hard disk, removable magnetic tape cassette, flash memory, redundant array of independent disks (RAID), etc.) for storing files including an operating system, applications, executable instructions, and data. Memory 1560 may also include programs, such as program 1580, which includes instructions for performing the processes described herein. For example, program 1580 may include instructions for receiving activation signals (e.g., from an actuator of applicator 100, or, for example, from a virtual trigger from an external user device and / or from a display screen of user interface 87), outputting a first control signal to a motor to actuate a piston associated with an actuation corresponding cartridge, and / or outputting a second control signal to a switch to provide voltage from a voltage supply source of HV module 86 to a voltage line. In addition, the controller 1500 may include a data storage device 1590 that can store data associated with parameters such as adjusting airflow, fluid flow and / or voltage for a particular treatment solution.

[0208] Figure 18-21 This is a flowchart of an example process for operating the reusable applicator 100 / disposable cartridge 50, 250, 350, 450, 550 system according to this disclosure. Specifically, Figure 18This is a flowchart of an example process 1800 for managing the operation of the applicator 100 described herein. In process 1800, the microcontroller unit can be woken up to determine if setup data is present (step 1802). If so, the applicator 100 system can be woken up to execute the main task process (step 1804). The main task process of step 1804 may include a proximity task step 1808, a stepper motor task 1810, a menu task 1812, and an MCU sleep mode 1814. In some aspects, the main task of step 1804 may be initiated upon detection of input from an accelerometer in communication with it (e.g., in response to detecting a predetermined change in acceleration above a threshold indicating user movement of the applicator 100). In some aspects, the proximity task 1808 may be initiated when a corresponding proximity sensor (e.g., target sensor 45) detects that a target site is within the threshold spray range of the applicator 100. In some aspects, the proximity task step 1808 may be initiated by starting and / or stopping actuation of an associated actuator (e.g., a button or capacitive input on the display of the user interface 87).

[0209] If, in step 1802, the system determines that no setup data exists, then step 1806 of the setup task of the applicator 100 is executed. In some aspects, step 1806 may include inputting setup data (e.g., via the display screen of the user interface 87). When setup data is input, a menu task 1812 may be executed. If no actuation or other input is received within a predetermined time period, then in step 1814, the system enters MCU sleep mode.

[0210] Figure 19This is a flowchart of an example process 1900 utilizing certain aspects of process 1800. In process 1900, the microcontroller unit can be woken up to initialize all systems and subsystems of the applicator 100 (step 1902). Such initialization may include a startup setup task 1904, a menu task 1906, a main task 1908, a proximity task 1910, a stepper motor task 1912, and other initialization tasks. After completing step 1902, a step of reading non-volatile memory 1914 is performed, and if the non-volatile memory is not empty (step 1916), the system determines whether all variables are loaded (step 1918). If all variables are loaded, the main task 1804 of process 1800, previously discussed, can be executed. If the non-volatile memory is empty in step 1916, the system can play a welcome animation on the display screen of interface 87 (step 1922). Similarly, if it is determined in step 1918 that all variables have not been loaded, step 1922 can be similarly executed by the system. When step 1922 is completed in any context, and after waiting for a predetermined period of time (e.g., approximately 3 seconds), the previously established task step 1806 from process 1800 can be executed.

[0211] Figure 20 This is a flowchart of the example process setup task 1806 regarding the previous process 1800 of initiating a wireless connection between example applicator 100 and wireless network.

[0212] Figure 21 The flowchart of the example process establishment task 1812 of the previous process 1800 is about initiating a wireless connection between the example applicator 100 and an external device, such that the external device (e.g., a mobile computing device such as a smartphone, tablet computer, etc.) can control and / or monitor one or more aspects of the operation of the applicator 100, including but not limited to the operation of the box attached thereto.

[0213] Figure 22 This is a flowchart of the example process main task 1804 concerning the previous process 1800 of initializing all systems and subsystems of the example applicator 100. Figure 23 From Figure 22 The flowchart continues and is specifically described in those examples where a grounding chain (strep) exists, detailing example sub-steps related to identifying and managing operations associated with the grounding strip and any associated grounding signals. Figure 23 and Figure 24 Example steps involving the operation of loading and managing components of any of the boxes described so far using the example applicator 100 of this disclosure are also described. For example, but not limited to, in Figure 23In step 2330, the box location can be analyzed to determine if it has been correctly installed. If not, an animation can be played (step 2332) until the MCU can eventually enable sleep mode execution (step 2336). If it is determined that the box is correctly installed (step 2330), in step 2402, box details can be read to determine certain information, including whether the box is genuine (step 2410), whether the OTP has been blown (step 2412), whether the box identification conforms to or is compatible with the current firmware and / or hardware of the applicator 100 (step 2422), whether the box ID indicates that its contents are preservatives (step 2424), whether it includes stem cells (step 2426), and / or whether it is constructed for electrospinning (step 2428). In these example processes, other aspects of the corresponding box can also be identified and evaluated. For example, other solution types and the box's origin and destination can be analyzed, whether its contents remain completely sealed, whether the box has been previously loaded into the applicator, whether the prescribing entity (e.g., a doctor or other operator has requested the box), and whether the box is associated with a specific patient or intended application.

[0214] depending on Figure 24 The system can then move to the result of certain sub-steps in the process. Figure 25 The process, therefore, steps 2502 (system setup for the preservative medium), 2504 (system setup for the stem cell medium), and 2506 (system setup for the electrospinning medium) can respectively initiate system setup in steps 2508, 2510, and 2512, and then continue the previous process. Figure 18 The remaining operational tasks described in process 1800, such as Figure 26 and Figure 27 This is further illustrated in the text. For example, in... Figure 27 In the process, a start / end can be set (step 2702), an OTP drill bit loaded on the cassette containing the applicator 100 can be set (step 2704), and then the stepper of the applicator can be moved forward according to the contents (i.e., the medium of the contents of the corresponding cassette) (step 2706). Then, proximity task 1808 can be read, and if satisfactory, stepping task 1810 can be executed. In some aspects, the result of proximity task 1808 can be presented on the display screen of interface 87 and / or presented in one or more LEDs associated therewith.

[0215] Figure 28 This is a flowchart of an example process for proximity task 1808, which is based on readings from one or more proximity sensors from the applicator 100 and related calculations for sensing and management operations.

[0216] Figure 29This is a flowchart of stepping task 1810, an example of the previous process 1800, which describes the operation of the stepper motor of the applicator 100 along with the firing of contents from the box loaded with the applicator 100 to the target site.

[0217] Figure 30 This is a flowchart of an example process that can be used before performing main task 1804 and / or putting the MCU into sleep mode (step 3020). For example, the process may include managing feedback from the accelerometer, manual triggers, actuation of the start / end button, the state of the grounding strip, signals from the grounding strip, the presence of user grounding, and feedback from limit switches.

[0218] Figure 31 This is a flowchart of a method 3100 for operating an example electrostatic applicator system. Step 3110 of method 3100 may include inserting a first disposable cartridge into the chamber housing of the electrostatic applicator system such that a voltage contact at a first end of a voltage line within the first disposable cartridge contacts a voltage contact of the electrostatic applicator system; a first end of an air supply port within the first disposable cartridge is fluidly connected to an air supply port of the electrostatic applicator system; and a plunger of a syringe within the first disposable cartridge is aligned with a piston of the electrostatic applicator system, the syringe containing a first fluid. Step 3120 of method 3100 may include actuating a motor via an activation input to the electrostatic applicator system and delivering a voltage potential to a delivery tube of the first disposable cartridge.

[0219] Figure 32 This is a computer-implemented method 3200 for operating an electrostatic applicator system. Step 3210 of method 3200 may include actuating a motor via an activation input to the electrostatic applicator system and / or delivering a voltage potential via a voltage line of a disposable cartridge from a high-voltage module of the electrostatic applicator system to a delivery tube of a disposable cartridge removably attached to a chamber housing of the electrostatic applicator system. Step 3220 of method 3200 may include propelling the fluid contents of the disposable cartridge through the delivery tube by pushing a stop of a syringe via a motor. Step 3230 of method 3200 may include electrostatically charging the fluid contents via the voltage line while in the delivery tube. Step 3240 of method 3200 may include dispensing the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge onto a treatment site.

[0220] The specific configuration, material selection, and dimensions and shapes of various components can be varied according to the specific design specifications or constraints of the system or method constructed based on the principles of the disclosed technology. These variations are intended to be included within the scope of the disclosed technology. Therefore, the currently disclosed embodiments are to be considered illustrative rather than restrictive in all respects. It will be apparent from the foregoing that while specific forms of this disclosure have been shown and described, various modifications may be made without departing from the spirit and scope of this disclosure, and all changes falling within the meaning and scope of their equivalents are intended to be included therein.

[0221] The following provisions set forth non-limiting embodiments of this disclosure:

[0222] 1. A disposable fluid delivery system for an electrostatic applicator, comprising:

[0223] A nozzle housing, comprising an air supply port, a voltage port, and a delivery outlet;

[0224] A voltage line includes contacts communicating with a delivery tube in fluid communication with a delivery outlet, the voltage line being configured to be electrically connected to a high-voltage module and to charge the fluid contents within the delivery tube with static electricity;

[0225] The syringe includes a barrel portion and a plunger configured to propel fluid from within the barrel portion and through a delivery tube; and

[0226] A housing that at least partially surrounds a nozzle housing, a voltage line, and a syringe.

[0227] 2. The disposable fluid delivery system according to Clause 1 further includes a voltage tube electrically connected to a voltage port, wherein the voltage line extends between a contact in communication with the delivery tube and a contact port on the wall of the housing.

[0228] 3. The disposable fluid delivery system according to Clause 2, wherein the voltage tube and voltage line comprise a substantially S-shape.

[0229] 4. The disposable fluid delivery system according to Clause 2, wherein the voltage tube and voltage line include a linear shape.

[0230] 5. The disposable fluid delivery system according to Clause 2, wherein the voltage tube and voltage line include a basic curved shape.

[0231] 6. The disposable fluid delivery system according to Clause 2 further includes an air supply pipe connected to the air supply port.

[0232] 7. The disposable fluid delivery system according to Clause 2, wherein the syringe contains contents including one or more of preservatives, disinfectant solutions, analgesics, exosomes, biological agents and / or liquid bandage solutions.

[0233] 8. The disposable fluid delivery system according to Clause 2, wherein the analgesic includes one or more of lidocaine, levobupivacaine, asimexine, ketorolac, and ceftazidime.

[0234] 9. The disposable fluid delivery system according to Clause 2, wherein the biological agent comprises one or more of stem cells and / or mammalian cells.

[0235] 10. The disposable fluid delivery system according to Clause 2, wherein the preservative and / or disinfectant solution comprises chlorhexidine gluconate and / or povidone-iodine.

[0236] 11. The disposable fluid delivery system according to Clause 1, wherein the housing is a moldable plastic material.

[0237] 12. The disposable fluid delivery system according to the clause, wherein the cartridge housing includes a plurality of moldable plastic segments that can be joined to produce a single integrated component.

[0238] 13. The disposable fluid delivery system according to Clause 1, wherein the contacts of the voltage line include a wire loop that at least partially surrounds the outer surface of the delivery tube to provide a voltage potential of about 1V to about 40kV.

[0239] 14. The disposable fluid delivery system according to Clause 1, wherein the contacts of the voltage line are in physical contact with the outer surface of the delivery tube to provide a voltage potential of about 1V to about 40kV.

[0240] 15. The disposable fluid delivery system according to Clause 1, wherein the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from an air supply port and fluid from the syringe barrel portion and equally discharge fluid charged by a voltage line.

[0241] 16. The disposable fluid delivery system according to Clause 1 further includes:

[0242] A reusable electrostatic applicator includes a housing chamber sized and shaped to receive a housing. The reusable electrostatic applicator includes:

[0243] High-voltage module, configured to be electrically connected to the voltage line; and

[0244] The piston is positioned adjacent to the housing and configured such that when the housing is assembled with the housing, the piston advances a plunger that surrounds the housing.

[0245] 17. The disposable fluid delivery system according to Clause 16, wherein the reusable electrostatic applicator comprises:

[0246] The motor is configured as a moving piston;

[0247] One or more processors; and

[0248] A memory that stores instructions, which are reusable electrostatic applicators when executed by one or more processors:

[0249] Receive activation signal;

[0250] The control signal is output to the motor to actuate the piston; and

[0251] The control signal is output to the switch to supply voltage from the high-voltage module to the voltage line.

[0252] 18. In the disposable fluid delivery system described in Clause 17, the motor is a stepper motor, a linear actuator, a worm gear motor, and / or a planetary gear motor.

[0253] 19. In the disposable fluid delivery system described in Clause 17, the motor is a driveable actuator system that uses dynamic transmission of applied force.

[0254] 20. The disposable fluid delivery system according to Clause 17, wherein the reusable electrostatic applicator further includes a display screen, and wherein the activation signal is input to a user on the display screen.

[0255] 21. The disposable fluid delivery system according to Clause 17, wherein the reusable electrostatic applicator further includes an actuator, and wherein the activation signal is a user input received by the actuator.

[0256] 22. The disposable fluid delivery system according to Clause 21, wherein the reusable electrostatic applicator comprises:

[0257] Housing base, housing base includes voltage source;

[0258] Device housing, the device housing including a housing chamber; and

[0259] The handle extends between the base and the device housing.

[0260] 23. The disposable fluid delivery system according to Clause 22, wherein the cartridge chamber is positioned within the device housing such that the actuator is positioned below the cartridge chamber relative to the horizontal direction.

[0261] 24. The disposable fluid delivery system according to Clause 17, wherein the reusable electrostatic applicator further includes a wireless antenna, and wherein the activation signal is a wireless signal received from a remote external user device.

[0262] 25. An electrostatic applicator system for delivering a treatment solution to a target site, comprising:

[0263] A portable, reusable electrostatic applicator comprising:

[0264] Device housing, configured for handheld use;

[0265] The motor is located inside the device housing and is configured to drive a piston.

[0266] Voltage source in the device housing;

[0267] High-voltage modules electrically connected to a voltage source; and

[0268] Box chamber; and

[0269] Disposable box, removably insertable into box chamber, the disposable box includes:

[0270] The nozzle housing includes an air supply port, a voltage port, and a delivery outlet.

[0271] The voltage line includes contacts that communicate with the delivery tube, which is in fluid communication with the delivery outlet;

[0272] The syringe includes a barrel portion and a plunger configured to propel fluid from within the barrel portion and through a delivery tube; and

[0273] The housing at least partially surrounds the nozzle housing, voltage line, and syringe.

[0274] 26. The electrostatic applicator system according to Clause 25, wherein the syringe contains a fluid, the fluid comprising one or more of a preservative, disinfectant solution, analgesic, exosome, biological agent and / or liquid bandage solution.

[0275] 27. The electrostatic applicator system according to Clause 26, wherein the analgesic includes one or more of lidocaine, levobupivacaine, asimexin, ketorolac, and ceftazidime.

[0276] 28. The electrostatic applicator system according to Clause 26, wherein the biological agent comprises one or more stem cells and / or mammalian cells.

[0277] 29. The electrostatic applicator system according to Clause 25, wherein the voltage line and the voltage tube including the voltage line in the housing have linear and / or curved or substantially S-shaped shapes.

[0278] 30. The electrostatic applicator system according to Clause 25, wherein the housing is made of a moldable plastic material.

[0279] 31. The electrostatic applicator system according to Clause 30, wherein the housing includes a plurality of moldable plastic connecting sections.

[0280] 32. The electrostatic applicator system according to Clause 25, wherein the chamber includes a wall, the wall including a high-voltage contact electrically connected to a high-voltage module and an air supply port fluidly connected to a pump located in the device housing;

[0281] Among them, the voltage line is electrically connected to the high-voltage contact of the wall; and

[0282] The contacts of the voltage line are in physical contact with the outer surface of the delivery tube to provide a voltage potential of approximately 1V to approximately 40kV.

[0283] 33. The electrostatic applicator system according to Clause 25, wherein the HV module includes a plurality of rotatable diodes, such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotatable diodes.

[0284] 34. The electrostatic applicator system according to Clause 25, wherein the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system.

[0285] 35. The electrostatic applicator system according to Clause 25, wherein the delivery tube, when assembled with the syringe and nozzle housing, is configured to receive air from the air supply port and fluid from the barrel portion of the syringe and equally discharge fluid charged by the voltage line.

[0286] 36. The electrostatic applicator system according to Clause 25, wherein the disposable cartridge includes an air supply tube connected to an air supply port.

[0287] 37. The electrostatic applicator system according to Clause 25, wherein the device housing includes a handle, and a voltage source is disposed within a housing base of the device housing, and wherein the handle is disposed between the device housing and the base.

[0288] 38. The electrostatic applicator system according to Clause 25, wherein the reusable electrostatic applicator comprises:

[0289] One or more processors; and

[0290] A memory that stores instructions, which are reusable electrostatic applicators when executed by one or more processors:

[0291] Receive activation signal; and

[0292] The control signal is output to the motor, and the control signal controls: (a) the voltage potential from the high-voltage module through the voltage line to the delivery tube, (b) the position of the piston and plunger of the disposable cartridge and / or (c) the pump that regulates the airflow from the device housing into the air supply port.

[0293] 39. The electrostatic applicator system according to Clause 38, wherein the disposable cartridge includes an integrated memory that includes information relating to one or more operating parameters of the contents stored in the syringe and / or another fluid reservoir within the disposable cartridge.

[0294] In this reusable electrostatic applicator, one or more processors are configured to communicate with an integrated memory to retrieve information related to the contents of a disposable cartridge and to control at least one of the flow rate, voltage potential, and nozzle settings.

[0295] 40. The electrostatic applicator system according to Clause 38, wherein the disposable cartridge includes an integrated memory, the integrated memory including information relating to the characteristics of the contents stored in the syringe and / or another fluid reservoir within the disposable cartridge.

[0296] In this reusable electrostatic applicator, one or more processors are configured to communicate with an integrated memory to retrieve information related to the contents of the disposable cartridge and to control motor speed, air intake, and / or applied voltage.

[0297] 41. The electrostatic applicator system according to Clause 39, wherein the memory is embedded in the processor of the electrostatic applicator system and includes operating instructions for operating the electrostatic applicator system.

[0298] 42. The electrostatic applicator system according to Clause 39, wherein the near field communication (NFC) tag includes a memory.

[0299] 43. The electrostatic applicator system according to Clause 42, further comprising a display screen, wherein the activation signal is input to a user on the display screen.

[0300] 44. The electrostatic applicator system according to clause 42 further includes a display screen, wherein: the instructions also include:

[0301] Read NFC information related to the operating parameters of the disposable box; and

[0302] The NFC information read is displayed on the screen.

[0303] 45. The electrostatic applicator system according to Clause 38 further includes an actuator, wherein the activation signal is a user input received by the actuator.

[0304] 46. ​​The electrostatic applicator system according to Clause 38 further includes a wireless antenna, wherein the activation signal is a wireless signal received from an external user device.

[0305] 47. The electrostatic applicator system according to Clause 38 further includes an accelerometer configured to output a movement signal to one or more processors in response to detecting movement of the electrostatic applicator system.

[0306] 48. The electrostatic applicator system according to Clause 47 further includes: a display screen on the electrostatic applicator system, the display screen being activated in response to a wake-up signal received from one or more processors of a movement signal;

[0307] Furthermore, the activation signal is an input sent to the user on the display screen.

[0308] 49. The electrostatic applicator system according to Clause 38, wherein the electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and the intended target;

[0309] Among them, in response to the distance being within a predetermined distance threshold, one of the control signals is output to the motor; and

[0310] In response to the distance being within a predetermined distance threshold, one of the control signals is output to the switch to control the voltage of the electrostatic applicator system.

[0311] 50. The electrostatic applicator system according to Clause 38, wherein the electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and a intended target, wherein, in response to the distance being greater than or less than a predetermined distance threshold, one of the control signals is output to prevent operation of the motor.

[0312] 51. The electrostatic applicator system according to Clause 38, wherein the electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and a intended target, wherein, in response to the distance being greater than or less than a predetermined distance threshold, one of the control signals is output to a switch to prevent voltage delivery by the electrostatic applicator system.

[0313] 52. A method for operating an electrostatic applicator system, comprising:

[0314] Insert the first disposable cartridge into the chamber housing of the electrostatic applicator system, such that:

[0315] The voltage contact at the first end of the voltage line inside the first disposable box contacts the voltage contact of the electrostatic applicator system.

[0316] The first end of the air supply port inside the first disposable cartridge is fluidly connected to the air supply of the electrostatic applicator system; and

[0317] The plunger of the syringe within the first disposable cartridge is aligned with the piston of the electrostatic applicator system; the syringe contains a first fluid; and

[0318] The motor is actuated by activating the electrostatic applicator system, and a voltage and potential are delivered to the delivery tube of the first disposable cartridge.

[0319] 53. The method according to Clause 52, wherein the actuating motor causes the first fluid from the syringe to be propelled through the delivery tube and sprayed as atomized, electrostatically charged droplets onto the target site in a predetermined spray pattern.

[0320] 54. The method described under clause 52 further includes:

[0321] Remove the first disposable cartridge from the chamber shell; and

[0322] A second disposable cartridge is inserted into the chamber housing, wherein the second disposable cartridge contains a second fluid.

[0323] 55. The method according to clause 54, wherein the second disposable box is configured for electrospinning, the method further comprising:

[0324] The motor is actuated by a second activation input to the electrostatic applicator system, and a voltage potential is delivered to the delivery tube of the second disposable cartridge, so that the second fluid of the syringe in the second disposable cartridge is delivered from the second fluid as electrospun fibers to the target site by the delivery tube of the second disposable cartridge.

[0325] 56. The method according to Clause 54, wherein the first disposable cartridge and the second disposable cartridge each include an integrated memory, the integrated memory including information relating to operating parameters of the first fluid and the second fluid, respectively, and wherein inserting the first disposable cartridge or the second disposable cartridge into the chamber housing causes the operating parameters to be transmitted to the memory of the electrostatic applicator system, the operating parameters including at least one of motor speed, air intake, and voltage applied to the delivery tube of the respective disposable cartridge.

[0326] 57. The method according to Clause 56, further comprising:

[0327] When one of the first or second disposable cartridges is inserted into the chamber housing, the registry associated with the operating parameters of the first or second disposable cartridge is marked as a used cartridge; and

[0328] When it is determined that the first disposable box or the second disposable box is a used box, prevent motor actuation and / or prevent the delivery tube of the first disposable box or the second disposable box from delivering voltage or potential.

[0329] 58. The method described in the clause, wherein the first disposable cartridge and the second disposable cartridge contain different fluids.

[0330] 59. The method according to Clause 54, wherein the first disposable cartridge and the second disposable cartridge include at least one of a first fluid and / or a second fluid stored in the respective disposable cartridge, depending on the different voltage lines and different delivery tubes of the respective nozzle housings.

[0331] 60. The method according to Clause 52, wherein providing activation input includes inputting information related to the first fluid into a display screen on the electrostatic applicator system; and providing the input to the display screen.

[0332] 61. The method according to Clause 52 further includes pairing the electrostatic applicator system to an external user device via a short-range wireless connection, wherein providing activation input includes inputting information related to the first fluid to the external user device and providing the input to a display screen of the external user device.

[0333] 62. A computer-implemented method for operating an electrostatic applicator system, the method comprising:

[0334] The activation input to the electrostatic applicator system actuates the motor and / or delivers voltage and potential from the high-voltage module of the electrostatic applicator system to the delivery tube of the disposable box, which is detachably attached to the chamber housing of the electrostatic applicator system, via the voltage line of the disposable box.

[0335] The plunger of the syringe is pushed by a motor, which propels the fluid contents of the disposable cartridge through the delivery tube.

[0336] Electrostatic charge is applied to the fluid contents in the delivery tube via a voltage line; and

[0337] The electrostatically charged fluid contents are ejected from the nozzle assembly of the disposable cartridge onto the treatment site.

[0338] 63. The computer-implemented method according to Clause 62 further includes:

[0339] The fluid contents in the syringe barrel near the delivery tube are electrostatically charged by a voltage line.

[0340] 64. The computer-implemented method according to Clause 62, wherein the step of emitting an electrostatically charged fluid content from a nozzle assembly includes controlling the intake of air from an air supply to a disposable cartridge from an electrostatic applicator system to atomize the electrostatically charged fluid content into droplets of a predetermined spray pattern onto a target site.

[0341] 65. The computer-implemented method according to Clause 62, wherein the step of emitting electrostatically charged fluid contents from a nozzle assembly includes delivery of the electrostatically charged fluid contents as electrospun fibers.

[0342] 66. The computer-implemented method according to clause 62, further comprising detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and

[0343] In response to a distance within a predetermined distance threshold, an activation input is transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0344] 67. The computer-implemented method according to clause 62, further comprising detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and

[0345] In response to a distance greater than or less than a predetermined distance threshold, motor actuation is prevented and / or the high-voltage module is prevented from delivering voltage potential.

[0346] 68. The computer-implemented method according to clause 62, further comprising: activating a wake-up signal from one or more processors of the electrostatic applicator system via a display screen on the electrostatic applicator system in response to one or more processors receiving a movement signal; and

[0347] In response to a wake-up signal, an activation input is transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0348] 69. The computer-implemented method according to claim 62, wherein the disposable cartridge includes an integrated memory that includes information relating to operating parameters of the fluid contents stored within the syringe, the method further comprising:

[0349] One or more processors of the reusable electrostatic applicator communicate with an integrated memory to retrieve information related to the fluid contents of a disposable cartridge; and

[0350] Control at least one of flow rate, voltage potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, including motor speed, air intake, and / or the voltage applied to the disposable cartridge.

[0351] 70. The computer-implemented method according to Clause 62, wherein the memory is embedded in the processor of the electrostatic applicator system and includes operating instructions for operating the computer-implemented method of the electrostatic applicator system.

[0352] 71. A system for operating an electrostatic applicator system, comprising:

[0353] At least one memory for storing instructions; and

[0354] At least one processor, configured to execute instructions to perform operations including the following:

[0355] The activation input to the electrostatic applicator system actuates the motor and / or delivers voltage and potential from the high-voltage module of the electrostatic applicator system to the delivery tube of the disposable box, which is detachably attached to the box housing of the electrostatic applicator system, via the voltage line of the disposable box.

[0356] The plunger of the syringe is pushed by a motor, which propels the fluid contents of the disposable cartridge through the delivery tube.

[0357] When the fluid contents are in the delivery tube, a voltage line is used to statically charge the fluid contents; and

[0358] The electrostatically charged fluid contents are ejected from the nozzle assembly of the disposable cartridge onto the treatment site.

[0359] 72. The system according to Clause 71, wherein the step of emitting electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from the air supply of the electrostatic applicator system into the disposable cartridge to atomize the electrostatically charged fluid contents into droplets of a predetermined spray pattern onto the target site.

[0360] 73. The system according to Clause 71, wherein the step of ejecting these electrostatically charged fluid contents from the nozzle assembly includes delivering them as electrospun fibers from the electrostatically charged fluid contents to a target site at a predetermined rate.

[0361] 74. The system according to Clause 71 further includes: detecting the distance between the electrostatic applicator system and the intended target via a proximity sensor; and

[0362] In response to a distance within a predetermined distance threshold, an activation input is transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0363] 75. The system according to Clause 71 further includes: activating a wake-up signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system in response to receiving a movement signal from one or more processors; and in response to the wake-up signal, causing an activation input to be transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0364] 76. The system according to claim 71, wherein the disposable cartridge includes an integrated memory that includes information relating to one or more operating parameters of the fluid contents stored within the syringe, the operating parameters further including:

[0365] One or more processors of the reusable electrostatic applicator communicate with an integrated memory to retrieve information related to the fluid contents of a disposable cartridge; and

[0366] Control at least one of flow rate, voltage potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, including motor speed, air intake, and / or the voltage applied to the disposable cartridge.

[0367] 77. The system according to Clause 71, wherein the memory is embedded in the processor of the electrostatic applicator system and includes operating instructions for operating a computer-implemented method of the electrostatic applicator system.

[0368] 78. A non-transitory computer-readable medium storing instructions, which, when executed by a processor, cause the processor to perform a method for operating an electrostatic applicator system, the method comprising:

[0369] The activation input to the electrostatic applicator system causes motor actuation and / or voltage potential to be delivered from the high-voltage module of the electrostatic applicator system to the delivery tube of the disposable box, which is detachably attached to the system housing of the electrostatic applicator system, via the voltage line of the disposable box.

[0370] The plunger of the syringe is pushed by a motor, which propels the fluid contents of the disposable cartridge through the delivery tube.

[0371] When the fluid contents are in the delivery tube, a voltage line is used to statically charge the fluid contents; and

[0372] The electrostatically charged fluid contents are ejected from the nozzle assembly of the disposable cartridge onto the treatment site.

[0373] 79. The non-transitory computer-readable medium according to Clause 78, wherein the step of emitting electrostatically charged fluid contents from a nozzle assembly includes controlling air intake from an air supply to a disposable cartridge from an electrostatic applicator system to atomize the electrostatically charged fluid contents into droplets of a predetermined spray pattern onto a target site with the opposite charge.

[0374] 80. The non-transitory computer-readable medium as described in Clause 78, wherein the step of ejecting these electrostatically charged fluid contents from the nozzle assembly comprises delivering them as electrospun fibers from the electrostatically charged fluid contents at a predetermined rate and / or pattern to a target site with the opposite charge.

[0375] 81. The method further comprises, according to the non-transitory computer-readable medium described in Clause 78:

[0376] The distance between the electrostatic applicator system and the intended target is detected by a proximity sensor; and

[0377] In response to a distance within a predetermined distance threshold, an activation input is transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0378] 82. The method further comprises, according to the non-transitory computer-readable medium described in Clause 78:

[0379] The display screen on the electrostatic applicator system activates a wake-up signal from one or more processors of the electrostatic applicator system in response to a movement signal received by one or more processors; and

[0380] In response to a wake-up signal, an activation input is transmitted to actuate a motor and / or a high-voltage module to deliver a voltage potential.

[0381] 83. The non-transitory computer-readable medium according to Clause 78, wherein the disposable cartridge includes integrated memory, the integrated memory including information relating to one or more operating parameters of the fluid contents stored within the syringe, the method further comprising:

[0382] One or more processors of the reusable electrostatic applicator communicate with an integrated memory to retrieve information related to the fluid contents of a disposable cartridge; and

[0383] Control at least one of flow rate, voltage potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, including motor speed, air intake, and / or the voltage applied to the disposable cartridge.

Claims

1. A disposable fluid delivery system for an electrostatic applicator, comprising: A nozzle housing, the nozzle housing including an air supply port, a voltage port, and a delivery outlet; A voltage line, the voltage line including a contact in communication with a delivery tube in fluid communication with the delivery outlet, the voltage line being configured to be electrically connected to a high-voltage module and to charge the fluid contents within the delivery tube with static electricity; An injector comprising a barrel portion and a plunger configured to propel fluid from within the barrel portion and to allow fluid to pass through the delivery tube; as well as A housing that at least partially surrounds the nozzle housing, the voltage line, and the syringe. The delivery tube, when assembled with the syringe and the nozzle housing, is configured to receive air from the air supply port and fluid from the barrel portion of the syringe and discharge fluid that is equally charged by the voltage lines.

2. The disposable fluid delivery system according to claim 1, further comprising: A voltage tube electrically connected to the voltage port, wherein the voltage line extends between the contact in communication with the delivery tube and the contact port of the wall of the housing.

3. The disposable fluid delivery system according to claim 2, wherein, The syringe contains contents including one or more of the following: preservatives, disinfectant solutions, analgesics, exosomes, biological agents, and / or liquid bandage solutions.

4. The disposable fluid delivery system according to claim 1, wherein, The box shell is made of moldable plastic material, and the box shell includes multiple moldable plastic connectable sections.

5. The disposable fluid delivery system according to claim 1, wherein, The contacts of the voltage line include a wire loop that at least partially surrounds the outer surface of the delivery tube to provide a voltage potential of 1 V to 40 kV.

6. The disposable fluid delivery system according to claim 1, wherein, The contacts of the voltage line are in physical contact with the delivery tube to provide a voltage potential from 1 V to 40 kV.

7. The disposable fluid delivery system according to claim 1, further comprising: A reusable electrostatic applicator, comprising a housing chamber sized and shaped to receive the housing, the reusable electrostatic applicator comprising: A high-voltage module, configured to be electrically connected to the voltage line; and A piston positioned adjacent to the housing chamber and configured such that when the housing is assembled with the housing chamber, the piston advances the plunger surrounding the housing chamber.

8. The disposable fluid delivery system according to claim 7, wherein, The reusable electrostatic applicator includes: An electric motor configured to move the piston; One or more processors; and A memory storing instructions that, when executed by the one or more processors, enable the reusable electrostatic applicator. Receive activation signal; The control signal is output to the motor to actuate the piston; and A control signal is output to a switch to supply voltage from the high-voltage module to the voltage line.

9. The disposable fluid delivery system according to claim 8, wherein, The reusable electrostatic applicator includes: Housing base, the housing base including a voltage source; Device housing, the device housing including the housing chamber; and A handle that extends between the housing base and the device housing.

10. An electrostatic applicator system for delivering a treatment solution to a target site, comprising: Portable, reusable electrostatic applicator, including: Device housing, the device housing being configured for handheld use; The motor is located in the housing of the device and is configured to drive a piston; The voltage source in the housing of the device; A high-voltage module, the high-voltage module being electrically connected to the voltage source; and Box chamber; and A disposable box that can be removably inserted into the box chamber, the disposable box comprising: A nozzle housing, the nozzle housing including an air supply port, a voltage port, and a delivery outlet; A voltage line, the voltage line including a contact in communication with a delivery tube, the delivery tube being in fluid communication with the delivery outlet; A syringe, the syringe including a barrel portion and a plunger configured to propel fluid from within the barrel portion and through the delivery tube; and A housing that at least partially surrounds the nozzle housing, the voltage line, and the syringe. The delivery tube, when assembled with the syringe and the nozzle housing, is configured to receive air from the air supply port and fluid from the barrel portion of the syringe and discharge fluid that is equally charged by the voltage lines.

11. The electrostatic applicator system of claim 10, wherein, The chamber includes a wall, the wall including a high-voltage contact electrically connected to the high-voltage module and an air supply port fluidly connected to a pump located in the device housing; The voltage line is electrically connected to the high-voltage contact of the wall; and The contacts of the voltage line are in physical contact with the outer surface of the delivery tube to provide a voltage potential of 1 V to 40 kV.

12. The electrostatic applicator system according to claim 10, wherein, The high-voltage module includes a plurality of rotatable diodes, such that the high-voltage module is configured to generate both positive and negative high voltages depending on the orientation of the rotatable diodes.

13. The electrostatic applicator system according to claim 10, wherein, The high-voltage module includes a circuit board, which includes a first positive high-voltage multiplier system and a second negative high-voltage multiplier system.

14. The electrostatic applicator system of claim 10, wherein, The reusable electrostatic applicator includes: One or more processors; and A memory storing instructions that, when executed by the one or more processors, enable the reusable electrostatic applicator. Receive activation signal; and A control signal is output to the motor, the control signal controlling: (a) the voltage potential from the high-voltage module via the voltage line to the delivery tube, (b) the position of the piston and plunger of the disposable cartridge and / or (c) the pump that regulates the airflow from the device housing into the air supply port.

15. The electrostatic applicator system according to claim 14, wherein, The disposable cartridge includes an integrated memory containing information relating to one or more operating parameters of the contents stored in the syringe and / or another fluid reservoir within the disposable cartridge, wherein the one or more processors of the reusable electrostatic applicator are configured to communicate with the integrated memory to retrieve information relating to the contents of the disposable cartridge and to control at least one of flow rate, voltage potential, and nozzle settings.

16. The electrostatic applicator system of claim 15, further comprising: An accelerometer configured to output a movement signal to the one or more processors in response to detecting movement of the electrostatic applicator system; And a display screen on the electrostatic applicator system, the display screen being activated by a wake-up signal from the one or more processors in response to the one or more processors receiving the movement signal; and wherein the activation signal is input to the user on the display screen.

17. A method for operating an electrostatic applicator system according to any one of claims 10 to 16, comprising: Insert the first disposable cartridge into the chamber housing of the electrostatic applicator system such that: The voltage contact at the first end of the voltage line inside the first disposable box contacts the voltage contact of the electrostatic applicator system; The first end of the air supply tube inside the first disposable box is fluidly connected to the air supply port of the electrostatic applicator system; as well as The plunger of the syringe within the first disposable cartridge is aligned with the piston of the electrostatic applicator system, and the syringe contains a first fluid; as well as The motor is actuated by activating the electrostatic applicator system, and a voltage or potential is delivered to the delivery tube of the first disposable cartridge.

18. The method according to claim 17, wherein, The first disposable cartridge includes an integrated memory containing information related to operating parameters of the first fluid, and wherein inserting the first disposable cartridge into the chamber housing causes the operating parameters to be transmitted to the memory of the electrostatic applicator system, the operating parameters including at least one of the motor speed, air intake, and voltage applied to the delivery tube of the corresponding disposable cartridge.

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