A qistagnation and blood stasis acupoint patch and a preparation method thereof

Abstract

The present application relates to the technical field of Qizixuexu agent sticking, especially to a Qizixuexu acupoint sticking and a preparation method thereof, the Qizixuexu acupoint sticking comprises the following raw materials and weight parts, Anarhichas lupus, 3-7 parts; red peony root, 8-12 parts; peach kernel, 8-12 parts; gardenia, 8-12 parts; myrrh in vinegar, 8-12 parts; olibanum in vinegar, 8-12 parts; baizhi, 8-12 parts; sanqi, 8-12 parts; rhubarb, 8-12 parts; xiangfu, 8-12 parts; corydalis, 8-12 parts; safflower, 8-12 parts. The present application improves the Qizixuexu related symptoms of the elderly patients by preparing a specific Qizixuexu acupoint sticking, plays a role in multiple targets and multiple directions, and improves the treatment effect of the patients.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of Qizixuexu Decoction, in particular to a Qizixuexu acupoint patch and a preparation method thereof. BACKGROUND

[0002] Qizixuexu refers to the pathogenesis of blood stasis caused by long-term stagnation of Qi movement. The normal movement of blood relies on the promotion of Qi. If Qi movement is not smooth, blood cannot be moved, and blood stasis occurs.

[0003] Chinese medicine classifies clinical diseases using the method of syndrome differentiation. Blood stasis can be divided into Qizixuexu, cold blood stasis, Qi deficiency blood stasis, and liver blood stasis. Among them, Qizixuexu accounts for about 70%. Qizixuexu can lead to blood stasis, and blood stasis must be accompanied by Qizixuexu. Qizixuexu is mainly caused by emotional internal injury, depression, stagnation of Qi movement, and blood stasis. The main manifestations are chest and hypochondrium distension, wandering pain or obvious stabbing pain, fixed pain and cannot be touched, pain aggravated when touched, or hard mass, local purple and swollen; or emotional depression, irritable; or cyanotic complexion, exposed blue veins; women may have amenorrhea or dysmenorrhea, dark purple or clotted menstrual blood, or breast pain; purple tongue or ecchymosis, wiry and astringent pulse.

[0004] At present, the treatment of Qizixuexu mainly adopts taking Chinese medicine or Chinese patent medicine, cupping, acupuncture, scraping or dietary regulation. However, most patients with Qizixuexu are old people, and taking Chinese medicine or Chinese patent medicine will increase the burden on the old people's intestines and stomach; cupping or acupuncture is prone to infection, hemorrhagic disease, etc.; the treatment rate is slow when using dietary regulation, and the cooperation rate of old patients is low.

[0005] Therefore, the technical personnel in the art are committed to developing a Qizixuexu acupoint patch and a preparation method thereof. The specific Qizixuexu acupoint patch is prepared to improve the Qizixuexu related symptoms of old patients, and plays a role through multiple targets and multiple directions, thereby improving the treatment effect of patients. SUMMARY

[0006] The technical problem to be solved by the present application is to provide a Qizixuexu acupoint patch and a preparation method thereof. The specific Qizixuexu acupoint patch is prepared to improve the Qizixuexu related symptoms of old patients, and plays a role through multiple targets and multiple directions, thereby improving the treatment effect of patients.

[0007] The technical solution of the present application to solve the above technical problem is as follows:

[0008] A Qistagnation and Blood Stasis Acupoint Plaster comprises the following raw materials and weight parts: Anarctica root, 3-7 parts; red peony root, 8-12 parts; peach kernel, 8-12 parts; gardenia, 8-12 parts; vinegar myrrh, 8-12 parts; vinegar olibanum, 8-12 parts; Baizhi, 8-12 parts; Sanqi, 8-12 parts; rhubarb, 8-12 parts; Cyperus rotundus, 8-12 parts; Corydalis, 8-12 parts; safflower, 8-12 parts.

[0009] The beneficial effects of the above scheme are: the Anarctica root has the effects of anti-inflammatory, blood sugar reduction, and antioxidant; the red peony root has the effects of clearing heat and cooling blood, removing blood stasis and relieving pain; the peach kernel has the effects of activating blood and removing blood stasis, inhibiting blood clotting and hemolysis; the gardenia has the effects of clearing heat and removing dampness, cooling blood and detoxifying, and relieving pain; the vinegar myrrh has the effects of removing blood stasis and relieving pain, and removing swelling and promoting tissue regeneration; the vinegar olibanum has the effects of activating blood and relieving pain, and removing swelling and promoting tissue regeneration; the Baizhi has the effects of relieving the exterior and dispelling cold, dispelling wind and relieving pain; the Sanqi has the effects of removing blood stasis and stopping bleeding, and removing swelling and relieving pain; the rhubarb has the effects of purgation, clearing heat and removing blood stasis, and removing swelling and promoting tissue regeneration; the Cyperus rotundus has the effects of relieving pain, anti-inflammatory, and antibacterial; the Corydalis has the effects of relieving pain, sedation, improving blood flow dynamics, and improving blood rheology; and the safflower has the effects of activating blood and removing blood stasis, and relieving pain.

[0010] After the above raw materials are prepared into acupoint plasters according to a certain proportion, the acupoint plasters are applied to specific acupoints of patients according to the patient's condition and TCM differentiation, so as to improve the Qistagnation and Blood Stasis related symptoms of elderly patients, and play a role through multiple targets and multiple directions, thereby improving the treatment effect of patients.

[0011] On the basis of the above technical scheme, the application can also be improved as follows.

[0012] Further, the application comprises the following raw materials and weight parts: Anarctica root, 4-6 parts; red peony root, 9-11 parts; peach kernel, 9-11 parts; gardenia, 9-11 parts; vinegar myrrh, 9-11 parts; vinegar olibanum, 9-11 parts; Baizhi, 9-11 parts; Sanqi, 9-11 parts; rhubarb, 9-11 parts; Cyperus rotundus, 9-11 parts; Corydalis, 9-11 parts; safflower, 9-11 parts.

[0013] The beneficial effects of the above further scheme are: after the above raw materials are prepared into acupoint plasters according to a certain proportion, the acupoint plasters are applied to specific acupoints of patients according to the patient's condition and TCM differentiation, so as to improve the Qistagnation and Blood Stasis related symptoms of elderly patients, and play a role through multiple targets and multiple directions, thereby improving the treatment effect of patients.

[0014] Further, the following raw materials and weight parts are included, Anagallis arvensis, 5 parts; Red peony root, 10 parts; Peach kernel, 10 parts; Gardenia, 10 parts; Myrrh in vinegar, 10 parts; Olibanum in vinegar, 10 parts; Baizhi, 10 parts; Sanqi, 10 parts; Rhubarb, 10 parts; Cyperus rotundus, 10 parts; Corydalis, 10 parts; Safflower, 10 parts.

[0015] The beneficial effect of the above further scheme is: After the above raw materials are prepared into acupoint patches according to a certain proportion, and are applied to specific acupoints of patients according to the patient's condition and TCM differentiation, the symptoms related to Qi stagnation and blood stasis of the elderly patients are improved, the effect is exerted from multiple targets and multiple directions, and the treatment effect of the patients is improved.

[0016] An acupoint patch for Qi stagnation and blood stasis, comprising the acupoint patch for Qi stagnation and blood stasis as described above, comprising the following steps:

[0017] S100, crushing the weighed raw materials into fine powder and mixing uniformly, and sieving through a sieve;

[0018] S200, heating the honey to boiling, removing the floating scum and impurities, and then heating for the second time and keeping until the water content is 10% to 13%;

[0019] S300, mixing and stirring the raw materials sieved in step S100 and the honey refined in step S200 until a paste is formed;

[0020] S400, uniformly coating the paste in step S300 on the acupoint patch backing material to prepare an acupoint patch.

[0021] The beneficial effect of the above scheme is: The raw materials are crushed into fine powder and added to the paste prepared from honey to prepare an acupoint patch, which is beneficial to the application of the acupoint patch to the acupoints of the patient, and the slow release and action of the raw materials on the acupoints of the patient, the effect is exerted from multiple targets and multiple directions, and the treatment efficiency of the patient is improved.

[0022] Further, after step S400, it further includes storage, placing the acupoint patch in a sealed container, the storage temperature is 2°C to 8°C, and direct sunlight is avoided.

[0023] The beneficial effect of the above further scheme is: The acupoint patch is placed in a low-temperature sealed container to avoid the oxidation of the effective components of the acupoint patch by oxygen in the air, and to avoid the deterioration of the acupoint patch caused by direct sunlight.

[0024] Further, in step S100, the sieve is a 100-mesh to 120-mesh sieve.

[0025] The beneficial effect of the above further scheme is: The raw materials are finely crushed into fine powder, which is beneficial to the rapid release of medicinal power and the action on the acupoints of the patient.

[0026] Further, in step S200, the second heating temperature is 116-118℃.

[0027] The beneficial effect of the above further scheme is that the liquid surface presents uniform fish-eye-like light yellow bubbles during the second heating, the foam presents light red luster, the water in the honey is evaporated, and the water content in the paste is reduced.

[0028] Further, in step S300, the mixing ratio of the raw material and the honey is 80-120:10-50.

[0029] The beneficial effect of the above further scheme is that the drug is beneficial to penetrate into the subcutaneous tissue, expand the blood vessels, and promote the local tissue blood circulation. BRIEF DESCRIPTION OF DRAWINGS

[0030] Figure 1 The step flow chart of a specific embodiment of the present application is shown. DETAILED DESCRIPTION

[0031] The principles and features of the present application are described below in combination with the drawings, and the examples are only used to explain the present application, and are not used to limit the scope of the present application.

[0032] In the description of the present application, it should be understood that the terms "center", "length", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "inner", "outer", "peripheral side", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only used to facilitate the description of the present application and simplify the description, and therefore cannot be understood as indicating or implying that the system or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0033] In the description of the present application, the meaning of "a plurality of" is at least two, such as two, three, etc., unless otherwise explicitly specified and limited.

[0034] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection", "fixing" and the like should be understood in a broad sense, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise explicitly limited. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0035] As Figure 1As shown, a Qisteng Xueyu acupoint patch includes the following raw materials and weight parts: Anarctica root, 3-7 parts; red peony root, 8-12 parts; peach kernel, 8-12 parts; gardenia, 8-12 parts; vinegar myrrh, 8-12 parts; vinegar olibanum, 8-12 parts; Baizhi, 8-12 parts; Sanqi, 8-12 parts; rhubarb, 8-12 parts; Xiangfu, 8-12 parts; Corydalis, 8-12 parts; safflower, 8-12 parts.

[0036] In the present application, the monarch drug Anarctica root has the effects of anti-inflammatory, blood glucose reduction, and antioxidant; red peony root has the effects of clearing heat and cooling blood, removing blood stasis and relieving pain; peach kernel has the effects of activating blood and removing blood stasis, inhibiting blood clotting and hemolysis; gardenia has the effects of clearing heat, removing dampness, cooling blood, and relieving pain; vinegar myrrh has the effects of removing blood stasis and relieving pain, removing swelling and promoting tissue regeneration; vinegar olibanum has the effects of activating blood and relieving pain, removing swelling and promoting tissue regeneration; Baizhi has the effects of relieving superficies and dispelling cold, dispelling wind and relieving pain; Sanqi has the effects of removing blood stasis and stopping bleeding, removing swelling and relieving pain; rhubarb has the effects of purgation, clearing heat and removing blood stasis, and removing blood stasis and unblocking channels; Xiangfu has the effects of relieving pain, anti-inflammatory, and antibacterial; Corydalis has the effects of relieving pain, calming, improving hemodynamics, and improving blood rheology; safflower has the effects of activating blood and unblocking channels, removing blood stasis and relieving pain.

[0037] After the above raw materials are prepared into acupoint patches according to a certain proportion, the acupoint patches are applied to specific acupoints of patients according to the patient's condition and TCM differentiation to treat Qisteng Xueyu syndrome of elderly patients, and the acupoint patches play a role through multiple targets and multiple directions to improve the treatment effect of patients.

[0038] In another embodiment, a Qisteng Xueyu acupoint patch includes the following raw materials and weight parts: Anarctica root, 4-6 parts; red peony root, 9-11 parts; peach kernel, 9-11 parts; gardenia, 9-11 parts; vinegar myrrh, 9-11 parts; vinegar olibanum, 9-11 parts; Baizhi, 9-11 parts; Sanqi, 9-11 parts; rhubarb, 9-11 parts; Xiangfu, 9-11 parts; Corydalis, 9-11 parts; safflower, 9-11 parts.

[0039] In a specific embodiment, a Qisteng Xueyu acupoint patch includes the following raw materials and weight parts: Anarctica root, 5 parts; red peony root, 10 parts; peach kernel, 10 parts; gardenia, 10 parts; vinegar myrrh, 10 parts; vinegar olibanum, 10 parts; Baizhi, 10 parts; Sanqi, 10 parts; rhubarb, 10 parts; Xiangfu, 10 parts; Corydalis, 10 parts; safflower, 10 parts.

[0040] The present application also provides a preparation method of a Qisteng Xueyu acupoint patch, which includes the Qisteng Xueyu acupoint patch as described above and includes the following steps:

[0041] S100, the above-mentioned raw materials are crushed into fine powder and mixed uniformly, and sieved through a sieve with a mesh size of 100-120 meshes.

[0042] S200, heating the honey to boiling, removing the scum and impurities, and then heating again until the water content is 10% to 13%, wherein the second heating temperature is 116°C to 118°C.

[0043] S300, mixing and stirring the raw materials screened in step S100 and the honey refined in step S200 until a paste is formed, wherein the mixing ratio of the raw materials to the honey is 80 to 120:10 to 50.

[0044] S400, uniformly applying the paste in step S300 to an acupoint patch backing material to prepare an acupoint patch.

[0045] S400 also includes storage, placing the acupoint patch in a sealed container, storing at a temperature of 2°C to 8°C and avoiding direct sunlight.

[0046] Example One

[0047] The clinical data of inpatients from September 2023 to March 2024 in a hospital (including TCM department, neurology department one, neurology department two, rehabilitation medicine department, pain department, rheumatism and immunity department, sports medicine department, trauma one department, trauma two department, joint surgery department, general practice department, spine one department, spine two department, spine three department, minimally invasive spine department, hand and foot microsurgery department, bone disease orthopedic surgery department, and ear, nose and throat department) were collected.

[0048] Inclusion criteria: (1) patients with pain in legs, feet, elbows, waists, necks, and joints, aged over 65 years, diagnosed as qi stagnation and blood stasis by TCM doctors in the hospital; (2) willing to accept pain relief program treatment; (3) treatment cycle ≥7 days; (4) patients with no skin trauma or ulceration.

[0049] Exclusion criteria: (1) patients with severe heart, brain, and liver and kidney function; (2) patients with mental and speech disorders; (3) treatment cycle <7 days; (4) patients allergic to acupoint patch traditional Chinese medicine ingredients or any of flurbiprofen axetil or non-steroidal anti-inflammatory drugs.

[0050] Exclusion criteria: (1) patients who self-withdrew from the pain relief program; (2) patients who did not follow the pain relief program and used additional medication; (3) patients who were unwilling to cooperate with the treatment or transferred to another department; (4) patients who could not continue medication due to adverse reactions.

[0051] 1.2 Implementation of randomized controlled and blinded method

[0052] The 249 patients were divided into 3 groups by random number table method, 115 patients with qi stagnation and blood stasis, 101 patients with cold congealing blood stasis, and 33 patients with flurbiprofen. Double-blind method, that is, patients are divided into groups by random number table, and then the medicine is sent to the relevant department of nurses, who are responsible for giving the medicine to the patients. During the implementation of the treatment, both the patients and the nurses are blinded to prevent bias caused by subjective factors during the trial.

[0053] 1.3 Determination of sample size: sample size required for multiple sample rate comparison

[0054] Sample size = 3

[0055] Test water level a = 0.05

[0056] Test power 1-beta = 0.9000

[0057] Minimum population rate (estimated value) pmin = 0.7

[0058] Maximum population rate (estimated value) pmax = 0.9

[0059] The number of samples required for each group is n = 95

[0060] 1.4 Qi stagnation and blood stasis acupoint paste and preparation:

[0061] 1.4.1, accurately weigh: anagallis root, 5g; red peony root, 10g; peach kernel, 10g; gardenia, 10g; vinegar myrrh, 10g; vinegar olibanum, 10g; baizhi, 10g; sanqi, 10g; rhubarb, 10g; xiangfu, 10g; corydalis, 10g; safflower, 10g;

[0062] 1.4.2. Preparation method:

[0063] S100, crush the weighed raw materials into fine powder and mix evenly, and sieve through a sieve. Specifically, put the weighed traditional Chinese medicine into a grinder and crush it into fine powder and mix evenly, and sieve through a 100-120 mesh sieve. Different medicinal materials should be ground for different times according to their characteristics.

[0064] S200, heat the honey to boiling, remove the scum and impurities, heat again and keep until the water content is 10%-13%; the second heating temperature is 116-118℃. Specifically, put the appropriate amount of honey into a pot and heat slowly on low heat, stir constantly until the honey is completely dissolved, heat to boiling, remove the scum and impurities, continue to heat in the pot to 116-118℃, the liquid surface presents uniform fish eye-like light yellow bubbles, the foam presents light red luster, the water content is about 10%-13%, the hand twist has stickiness, but cannot be pulled into long white silk (medium honey).

[0065] S300, the raw materials screened in step S100 and the honey refined in step S200 are mixed and stirred until a paste is formed; the mixing ratio of the raw materials to the honey is 80-120:10-50. Specifically, a container is prepared, the crushed Chinese medicinal materials are poured into the container, and then an appropriate amount of refined honey is added. The amount of honey is determined according to the type and quantity of the Chinese medicinal materials (about 30 g of refined honey is added per 100 g of Chinese medicinal material powder), and the Chinese medicinal materials and the honey are mixed evenly with a spoon until a paste is formed.

[0066] S400, the paste in step S300 is uniformly coated on the acupoint sticking treatment paste backing material to prepare an acupoint paste.

[0067] S400 also includes storage, the acupoint paste is placed in a sealed container, the storage temperature is 2-8°C and direct sunlight is avoided. Specifically, the prepared paste is loaded into a stainless steel jar with a lid, and the jar is covered to maintain the sealing of the container to prevent the invasion of air and external bacteria, and is stored in a refrigerator at 2-8°C to avoid direct sunlight and high temperature.

[0068] 1.4.3 Preparation of Control Example One Cold Congestion and Blood Stasis Paste

[0069] 1. Accurately weigh: 10 g of Dahuang, 10 g of Sanqi powder, 10 g of Gushugu, 10 g of Danggui, 10 g of Niuxi, 10 g of Honghua, 10 g of Chishao, 10 g of Weilingxian, 10 g of Tougucao, and 10 g of Chuanxiong.

[0070] 1.4.4 Preparation method: the preparation method is the same as the method for preparing the Qi Stagnation and Blood Stasis Acupoint Paste described above.

[0071] 1.4.5 Preparation of Control Example Two

[0072] Buprofen gel paste (purchased from Beijing Pharmaceutical Co., Ltd. 312121-04, 311081-01).

[0073] 1.5 VAS score

[0074] Visual Analogue Scale (VAS) for pain; VAS score scale was used to score VAS before medication, on the third day of medication, and on the seventh day of medication, 0 for no pain, 1-3 for mild pain, sleep and activity not limited, and no need for drug analgesia, 4-7 for moderate pain, which affects sleep and eating, and needs regular drug analgesia, 8-10 for severe pain, which cannot be tolerated and must use NSAIDs and opioids.

[0075] 1.6 Adverse reactions

[0076] After acupoint sticking, due to different physical conditions of each person, the skin sensitivity to drugs is also different, and some patients have overlong drug application time and cause adverse reactions. The adverse reactions of patients include skin redness, swelling, itching and other symptoms. Stop applying drugs in time to avoid more serious adverse reactions.

[0077] 1.7 Statistical processing

[0078] The data in this study were analyzed by SPSS21.0 software. The normality and homogeneity of variance of the measurement data were tested. If normality and homogeneity of variance were met, independent sample t test was used for comparison between two groups, and chi-square test was used for comparison among multiple groups. If normality was not met, Mann-Whitney method was used for comparison between groups, and Kruskal-Wallis method was used for comparison among multiple groups. Chi-square test was used for comparison between groups of count data, and the test level α=0.05. 2

[0079] 2 Results

[0080] 2.1 Population information processing results

[0081] There were 101 patients in the cold blood stasis group, including 10 patients with skin allergy, 3 patients transferred to other departments or discharged, and finally 88 patients were included as the cold blood stasis group. There were 115 patients in the qi stagnation and blood stasis group, including 10 patients with skin allergy, 5 patients transferred to other departments or discharged, and finally 100 patients were included as the qi stagnation and blood stasis group. There were 33 patients in the flurbiprofen group, and there was no skin allergy, transfer to other departments or discharge. Comparison of age, gender, height and weight of patients in cold blood stasis group, qi stagnation and blood stasis group and flurbiprofen group showed that there was no difference between the three groups, and there was no statistical significance (H=0.623, P=0.732; χ2=3.965, P=0.138; H=2.006, P=0.367; H=1.653, P=0.438), as shown in Table 1 below:

[0082]

[0083] Table 1 Basic information of patients

[0084] 2.2 Comparison of VAS scores

[0085] Through Kruskal-Wallis H test, the results showed that there were differences in VAS scores of patients in cold blood stasis group, qi stagnation and blood stasis group and flurbiprofen group before medication, on the 3rd day and 7th day of medication, with statistical significance (H=23.981, P=0.000; H=51.992, P=0.000; H=34.768, P=0.000).

[0086] ​In the cold blood stasis group, compared with before treatment, the VAS scores of patients were significantly reduced on the 3rd and 7th day of treatment, with statistical significance (P=0.002; P=0.000); compared with the 3rd day of treatment, the VAS scores of patients on the 7th day had no difference, with no statistical significance (P=0.510). In the Qi stagnation and blood stasis group, compared with before treatment, the VAS scores of patients were significantly reduced on the 3rd and 7th day of treatment, with statistical significance (P=0.000; P=0.000); compared with the 3rd day of treatment, the VAS scores of patients on the 7th day had no difference, with no statistical significance (P=0.450). In the flurbiprofen group, compared with before treatment, the VAS scores of patients were significantly reduced on the 3rd and 7th day of treatment, with statistical significance (P=0.003; P=0.000); compared with the 3rd day of treatment, the VAS scores of patients on the 7th day were significantly reduced, with statistical significance (P=0.028).

[0087] Before treatment and on the 3rd day of treatment, the VAS scores of patients in the cold blood stasis group, the Qi stagnation and blood stasis group and the flurbiprofen group had no difference, with no statistical significance (H=0.695, P=0.706; H=5.102, P=0.078, wherein H represents probability distribution and p represents probability); on the 7th day of treatment, the VAS scores of patients among the three groups had difference, with statistical significance (H=14.834, P=0.001), as shown in Table 2 below:

[0088]

[0089] Table 2 Comparison of VAS scores of patients in the cold blood stasis group, the Qi stagnation and blood stasis group and the flurbiprofen group

[0090] Note: Compared with before treatment of each group, *P<0.05; compared with the 3rd day of treatment of each group, #P<0.05; on the 7th day, ^P<0.05 compared with the cold blood stasis group.

[0091] 2.4 Adverse reaction results

[0092] The main manifestations of adverse reactions of patients in the cold blood stasis group and the Qi stagnation and blood stasis group when using acupoint sticking were allergy (skin itching and redness), with 2 cases; there were 10 cases in the cold blood stasis group; while patients in the flurbiprofen group had no adverse reactions. Through chi-square test, the results showed that the incidence of adverse reactions of patients in the three groups had no statistical significance (χ2=3.966, P=0.138, wherein χ represents the value of variable), as shown in Table 3 below:

[0093]

[0094]

[0095] Table 3 Incidence of adverse reactions of patients in the cold blood stasis group, the Qi stagnation and blood stasis group and the flurbiprofen group

[0096] 2.5 Effect evaluation​

[0097] TCM uses the method of syndrome differentiation to classify clinical diseases. For blood stasis, it can be divided into qi stagnation and blood stasis, cold coagulation and blood stasis, qi deficiency and blood stasis, and liver qi and blood stasis. Among them, qi stagnation and blood stasis accounts for about 70%. The main manifestations are chest and diaphragm distension, wandering pain or obvious stabbing pain, fixed pain and cannot be touched, pain aggravated when touched, or hard mass, local cyanosis and swelling; or depressed mood, irritable; or cyanotic complexion, exposed blue veins; women may have amenorrhea or dysmenorrhea, dark purple or clotted menstrual blood, or breast pain; purple tongue or ecchymosis, and stringy and astringent pulse. For the above symptoms, qi stagnation and blood stasis acupoint paste can be applied at different acupoints after TCM pulse diagnosis and treatment (see the acupoint paste diagram for specific acupoints).

[0098] The first advantage of traditional Chinese medicine acupoint paste is comprehensive effect, not only analgesia, but also considering various symptoms of qi stagnation and blood stasis; the second is simple, convenient, cheap and effective. It is easy to operate, simple, convenient to learn, low in price, and the prescription is the experience accumulated for many years. The third is that TCM treatment plays a role in multiple targets and multiple directions, and can treat internal and surgical diseases, of course, on the basis of accurate TCM differentiation. Therefore, the treatment range is large, cost-effective, and multiple acupoints can be applied at the same time, as shown in the following Table 4:

[0099]

[0100] Table 4 Comparison of acupoint paste treatment effect

[0101] In summary, the western medicine paste has a larger area, the drug is a single component, and the paste can be applied anywhere. Compared with traditional Chinese medicine, it is also very convenient to use, but it cannot involve other diseases, and the price is relatively high, and allergic reactions also exist. The first advantage of traditional Chinese medicine acupoint paste is comprehensive effect, not only analgesia, but also considering various symptoms of qi stagnation and blood stasis.

[0102] In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples. In addition, those skilled in the art can combine and combine different embodiments or examples described in the present specification and the features of different embodiments or examples without contradiction.

[0103] The above merely describes preferred embodiments of the present application, and is not used to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A type of acupoint patch for qi stagnation and blood stasis, characterized in that: It is made from the following raw materials and parts by weight: Anachi root, 3 to 7 parts; Paeonia lactiflora, 8 to 12 parts; Peach kernels, 8 to 12 parts; Gardenia, 8 to 12 parts; vinegar-processed myrrh, 8 to 12 parts; vinegar-processed frankincense, 8 to 12 parts; Angelica dahurica, 8 to 12 parts; Panax notoginseng, 8 to 12 parts; Rhubarb, 8 to 12 parts; Cyperus rotundus, 8 to 12 parts; Corydalis rhizome, 8 to 12 parts; Safflower, 8 to 12 parts.

2. The acupoint patch for qi stagnation and blood stasis according to claim 1, characterized in that: It is made from the following raw materials and parts by weight: Anachi root, 4 to 6 parts; Red peony root, 9 to 11 parts; Peach kernel, 9 to 11 parts; Gardenia, 9 to 11 parts; vinegar-processed myrrh, 9 to 11 parts; vinegar-processed frankincense, 9 to 11 parts; Angelica dahurica, 9 to 11 parts; Panax notoginseng, 9 to 11 parts; Rhubarb, 9 to 11 parts; Cyperus rotundus, 9 to 11 parts; Corydalis rhizome, 9 to 11 parts; Safflower, 9 to 11 parts.

3. The acupoint patch for qi stagnation and blood stasis according to claim 1, characterized in that: It is made from the following raw materials and parts by weight: Anachi root, 5 parts; Red peony root, 10 parts; Peach kernel, 10 parts; Gardenia, 10 parts; Myrrh in vinegar, 10 parts; Frankincense in vinegar, 10 parts; Angelica dahurica, 10 parts; Panax notoginseng, 10 portions; Rhubarb, 10 portions; Cyperus rotundus, 10 portions; Corydalis rhizome, 10 portions; Safflower, 10 portions.

4. A method for preparing an acupoint patch for qi stagnation and blood stasis, characterized in that, The acupoint patch for qi stagnation and blood stasis as described in any one of claims 1 to 3 includes the following steps: S100. Crush the weighed raw materials into fine powder and mix them evenly, then sieve them. S200. Heat the honey to a boil, remove the foam and impurities, then heat it a second time and maintain the boiling point until the water content is 10% to 13%. S300: Mix and stir the raw materials selected in step S100 and the honey refined in step S200 until it becomes a paste. S400: The ointment from step S300 is evenly applied onto the backing material of the acupoint patch to prepare an acupoint patch.

5. The method for preparing the acupoint patch for qi stagnation and blood stasis according to claim 4, characterized in that, Step S400 also includes preservation, placing the acupoint patch in a sealed container, storing it at a temperature of 2℃~8℃ and avoiding direct sunlight.

6. The method for preparing the acupoint patch for qi stagnation and blood stasis according to claim 4, characterized in that, In step S100, the sieve is a 100-120 mesh sieve.

7. The method for preparing the acupoint patch for qi stagnation and blood stasis according to claim 4, characterized in that, In step S200, the temperature of the second heating is 116℃~118℃.

8. The method for preparing the acupoint patch for qi stagnation and blood stasis according to claim 4, characterized in that, In step S300, the mixing ratio of raw materials and bees is 80-120:10-50.

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