A batch pre-flushing device for a hemoperfusion cartridge and its usage method

Abstract

The present invention discloses a batch pre-flushing device for a hemoperfusion cartridge and a method for using the same. The device includes: a plurality of hemoperfusion cartridges, and the input end and the output end of each hemoperfusion cartridge can be respectively inserted into a shunt plate and a confluence plate through connecting tubes. The shunt plate is connected to a liquid end through a first pre-flushing liquid tube, and the confluence plate is connected to a waste liquid collector through a second pre-flushing liquid tube. The batch pre-flushing device for a hemoperfusion cartridge provided by the present invention can complete the pre-flushing function for one or more hemoperfusion cartridges as needed, reducing the use of nursing manpower and medical resources.

Description

Technical Field

[0001] The present invention relates to the technical field of hemodialysis, and particularly to a batch priming device for a hemoperfusion cartridge and a method for using the same. Background Art

[0002] Hemodialysis is one of the important methods commonly used in clinical treatment of end-stage renal disease. A hemoperfusion cartridge is an extracorporeal circulation technique mainly used to remove medium and large molecular toxins, drugs, or other harmful substances from a patient's blood. Priming of the hemoperfusion cartridge is a necessary step in hemoperfusion treatment. Among them, the quality of priming of the hemoperfusion cartridge is crucial for the effect of hemodialysis treatment.

[0003] However, in the prior art, the priming of the hemoperfusion cartridge can usually only be carried out for a single cartridge in a single priming. For one hemoperfusion treatment, one cartridge needs to be primed. Nurses are responsible for the treatment preparation work of multiple patients at the same time. If the liquid bag is not replaced in time and air enters the cartridge, the cartridge needs to be primed again with the priming solution, resulting in an extended single priming time. At the same time, due to the inability to meet the demand for large batch priming, the total priming time of multiple patients in charge of each nurse is long, wasting nursing manpower and medical resources. Summary of the Invention

[0004] The purpose of the present invention is to provide a batch priming device for a hemoperfusion cartridge and a method for using the same, so as to achieve the priming of multiple cartridges, meet the demand for large batch priming, reduce nursing manpower, and optimize medical resources.

[0005] To solve the above technical problems, on the one hand, the present invention provides a batch priming device for a hemoperfusion cartridge. The device includes: a plurality of hemoperfusion cartridges, the input end and the output end of each hemoperfusion cartridge can be respectively inserted into a flow distribution plate and a flow collecting plate through a connecting pipe, the flow distribution plate is connected to a liquid end through a first priming solution pipe, and the flow collecting plate is connected to a waste liquid collecting member through a second priming solution pipe.

[0006] Further, the flow distribution plate has an inlet, and a plurality of branches are provided in the flow distribution plate. One end of each branch is connected to the inlet, and the other end is connected to an insertion port.

[0007] Further, a switch is provided on each branch.

[0008] Further, the flow collecting plate has an outlet, and a plurality of branches are provided in the flow collecting plate. One end of each branch is connected to the outlet, and the other end is connected to an insertion port.

[0009] Further, the hemoperfusion cartridge is connected to a fixing component. The fixing component includes a fixing rod, a plurality of movable holes are provided inside the fixing rod, fixing blocks are provided in the movable holes, and the fixing blocks are detachably or fixedly connected to a connecting member for clamping the hemoperfusion cartridge.

[0010] Further, the connecting member includes a vibrating rod and a clamping element. One end of the vibrating rod is connected to the clamping element, and the other end is connected to the fixed block. The clamping element is used for clamping the hemoperfusion cartridge.

[0011] Further, the fixing assembly further includes a transmission rod, and the transmission rod is connected to a vibration motor.

[0012] Further, an installation member is installed on one side of the fixing rod. The installation member is detachably connected to a bubble detector. The input end of the bubble detector is connected to the controller, and the output end faces the hemoperfusion cartridge to detect bubbles in the hemoperfusion cartridge.

[0013] Further, on-off clamps are provided on the first pre-flushing liquid pipe and the second pre-flushing liquid pipe.

[0014] In a second aspect of the present invention, a method for using a batch pre-flushing device for a hemoperfusion cartridge is provided, including the following steps:

[0015] Step S11, connect a set number of hemoperfusion cartridges;

[0016] Step S12, set the pre-flushing program parameters;

[0017] Step S13, drive the pump to deliver the pre-flushing liquid and divert it into each hemoperfusion cartridge;

[0018] Step S14, start the vibration motor to vibrate the hemoperfusion cartridges;

[0019] Step S15, use the bubble detector to detect whether there is air in the hemoperfusion cartridge. If there is, an alarm message is sent in response to the alarm program parameters, and return to Step S14 according to the alarm message; if not, a pre-flushing end signal is sent in response to the pre-flushing end program parameters;

[0020] Step S16, according to the pre-flushing end signal, start the on-off clamp to block the first pre-flushing liquid pipe and the second pre-flushing liquid pipe.

[0021] The beneficial effects of the present invention are at least as follows: The liquid end passes the pre-flushing liquid through the first pre-flushing liquid pipe at a constant flow rate through the flow dividing plate, and then batch pre-flushes multiple hemoperfusion cartridges, so that the air in the multiple hemoperfusion cartridges is removed. At the same time of pre-flushing, the second pre-flushing liquid pipe is used to discharge the pre-flushing liquid passing through the hemoperfusion cartridge. Thus, the pre-flushing of multiple hemoperfusion cartridges is realized, the demand for large-batch pre-flushing is completed, and the use of nursing manpower and the waste of medical resources are reduced.

[0022] Furthermore, the number of hemoperfusion cartridges can be flexibly set according to needs. Description of the Drawings

[0023] Figure 1Schematic plan view of a batch pre - flushing device for a hemoperfusion cartridge in an embodiment of the present invention;

[0024] Figure 2 Schematic structural view of a flow - dividing plate in an embodiment of the present invention;

[0025] Figure 3 Schematic structural view of a hemoperfusion cartridge installed on a fixing rod in an embodiment of the present invention;

[0026] Figure 4 is Figure 3 Enlarged view at A in;

[0027] Figure 5 Schematic diagram of a controller connection medium in an embodiment of the present invention;

[0028] Figure 6 Flowchart of a method in an embodiment of the present invention. Detailed implementation manners

[0029] Hereinafter, embodiments of the present invention will be described in more detail with reference to the schematic diagrams, in which the preferred embodiments of the present invention are shown. It should be understood that those skilled in the art can modify the present invention described herein while still achieving the advantageous effects of the present invention. Therefore, the following description should be understood as a broad guidance for those skilled in the art and not as a limitation to the present invention.

[0030] In the following paragraphs, the present invention will be described more specifically by way of example with reference to the accompanying drawings. The advantages and features of the present invention will be clearer according to the following description and the claims. It should be noted that the drawings are all in a very simplified form and use non - precise scales, only for the purpose of facilitating and clearly assisting in explaining the objectives of the embodiments of the present invention.

[0031] As Figure 1 shown, an embodiment of the present invention provides a batch pre - flushing device for a hemoperfusion cartridge, including: a plurality of hemoperfusion cartridges 1, the input end and the output end of each hemoperfusion cartridge 1 can be respectively plugged into a flow - dividing plate 5 and a flow - collecting plate 6 through connecting tubes, the flow - dividing plate 5 is connected to a liquid end 15 through a first pre - flushing liquid tube 2, and the flow - collecting plate 6 is connected to a waste liquid collecting member 17 through a second pre - flushing liquid tube 3.

[0032] Among them, the hemoperfusion cartridge 1 is composed of a housing, a perfusion medium (such as activated carbon, resin, cellulose membrane, etc.), and liquid inlet and outlet ports. When in use, blood flows into the hemoperfusion cartridge 1 from one end (arterial end), and after passing through the perfusion medium, flows out from the other end (venous end). During this process, harmful substances are adsorbed or filtered by the medium, so as to achieve the purpose of purifying the blood. At present, in order to avoid serious complications such as air embolism caused by air entering the blood circulation, the hemoperfusion cartridge 1 is often designed with safety measures to prevent air from entering or facilitate air discharge during design.

[0033] Among them, the pre-flush solution provided at the liquid end is physiological saline. Heparin is pre-injected into the hemoperfusion cartridge 1 in advance. Heparinization is an anticoagulation measure taken to prevent blood from coagulating in the adsorption column of the hemoperfusion cartridge 1. Heparin is a potent anticoagulant drug that can effectively prevent the activation of blood coagulation factors and maintain the fluidity of blood during extracorporeal circulation.

[0034] Please refer to Figure 2 As shown, the flow distribution plate 5 is mainly used for the flow distribution after the pre-flush solution enters. The first pre-flush liquid pipe 2 is connected to the inlet 51 of the flow distribution plate 5. There are multiple branches in the flow distribution plate 5. One end of each branch is connected to the inlet 51, and the other end is connected to the insertion interface 52, so that the pre-flush solution can be distributed into multiple branches. Further, a switch 53 is provided on each branch to open the corresponding branch after the hemoperfusion cartridge 1 is connected to the insertion interface. Usually, the material and pipe diameter of each branch are the same to achieve basically the same flow rate and pressure, facilitating the pre-flush function for multiple hemoperfusion cartridges 1.

[0035] Among them, the first pre-flush liquid pipe 2 and the second pre-flush liquid pipe 3 are common medical infusion pipes. Larger-diameter infusion pipes are used to facilitate the flow of the pre-flush solution and meet the demand for a constant flow rate of the pre-flush solution by the flow distribution plate 5 and the confluence plate 6.

[0036] Usually, a driving pump 16 is also provided and acts on the first pre-flush liquid pipe 2. Further, at least one driving pump can also be provided in the flow distribution plate 5 to act on each branch.

[0037] The confluence plate 6 has basically the same structure as the flow distribution plate 5 and is mainly used to connect the hemoperfusion cartridge to the second pre-flush liquid pipe 3 so as to collect the waste liquid into the waste liquid collection member 17.

[0038] Further, on-off clamps 18 are provided on the first pre-flush liquid pipe 2 and the second pre-flush liquid pipe 3.

[0039] In this embodiment, the liquid end 15 passes the pre-flush solution through the first pre-flush liquid pipe 2 at a constant flow rate through the flow distribution plate 5, and then batch pre-flushes multiple hemoperfusion cartridges 1, so that the air in the multiple hemoperfusion cartridges 1 is removed. While pre-flushing, the second pre-flush liquid pipe 3 is used to discharge the pre-flush solution passing through the hemoperfusion cartridge 1. Thus, the pre-flush of multiple hemoperfusion cartridges 1 is realized, meeting the demand for large-batch pre-flushing, and reducing the use of manpower and waste of medical resources.

[0040] Please refer to Figure 3 and Figure 4 As shown, in a preferred embodiment, the hemoperfusion cartridge 1 is connected to a fixing component. Specifically, the fixing component includes a fixing rod 9. The fixing rod 9 is internally provided with multiple movable holes 10. Fixing blocks 11 are provided in the movable holes 10. The fixing blocks 11 are detachably connected or fixedly connected to the connecting member, and the connecting member is used for clamping the hemoperfusion cartridge 1.

[0041] For example, the connecting member includes a connecting rod 12 and a clamping member 13. One end of the connecting rod 12 is rotatably connected to the clamping element 13, and the other end is connected to the fixed block 11. The clamping member 13 is used to clamp the perfusion device 1.

[0042] It should be noted that the clamping member 13 is a plastic vise, and its clamping end fits the outer surface of the perfusion device 1. When clamping, through the rotation of the screw rod of the threaded rod, the perfusion device 1 is stably clamped to prevent the perfusion device 1 from falling off during vibration and accidentally damaging the perfusion device 1. Similarly, by reversing the threaded rod, the clamping end of the plastic vise is loosened to facilitate the removal of the perfusion device 1.

[0043] In addition, the clamping member 13 and the connecting rod 12 can also be fixedly connected, such as integrally formed. The clamping member 13 has a certain elasticity, so that the perfusion device 1 can be directly snapped in or pulled out.

[0044] Thus, the number of perfusion devices 1 required can be flexibly set on the fixed rod 9 according to actual needs to achieve the pre-flushing of one or more perfusion devices 1.

[0045] Furthermore, the fixing assembly further includes a transmission rod 7, and the transmission rod 7 is connected to a vibration motor 8.

[0046] For example, the vibration motor 8 is a small vibration motor 8 of hoyunstorm. Based on the oscillation scenario of the perfusion device 1, the small vibration motor 8 can meet the vibration requirements. Of course, motors of other specifications can also be selected.

[0047] The vibration motor 8 can be arranged on an external bracket, so that when the vibration motor 8 is started, it is convenient to drive the transmission rod 7 and the fixed rod 9 to vibrate.

[0048] In one example, when the vibration motor 8 is started, its output end drives the transmission rod 7 to vibrate, and the transmission rod 7 drives the fixed rod 9 to vibrate, thereby vibrating a plurality of perfusion devices 1, so that the air in the perfusion device 1 is discharged from the perfusion device 1 during vibration, and the perfusion device 1 is fully pre-flushed.

[0049] Furthermore, an installation member 14 is installed on one side of the fixed rod 9. The installation member 14 is detachably connected with a bubble detector. The input end of the bubble detector is connected to the controller, and the output end faces the perfusion device 1 to detect the bubbles in the perfusion device 1.

[0050] In this embodiment, the bubble detector adopts the ultrasonic detection principle. After the vibration of the perfusion device 1 is completed, ultrasonic waves are emitted by the ultrasonic probe to detect whether there is air in the perfusion device 1. If air is detected to exist, the controller (such as Figure 5After receiving the signal as shown, the controller starts the vibration motor 8 or manually starts the vibration motor 8 to vibrate again, continuously and thoroughly expelling the air in the perfusion device 1. When it is detected that there is no air in the perfusion device 1, the controller starts the buzzer to prompt the nurse that the pre-flushing is completed, and the perfusion device 1 is processed in a timely manner.

[0051] It should be noted that the controller is a single-chip microcomputer controller. By inputting the set parameters and program source code through the computer terminal, it receives the signal from the bubble detector and controls the start and stop of the vibration motor 8. The bubble detector is detachably connected to the fixed rod 9. When the fixed part vibrates, the bubble detector is detached to prevent damage to the internal components of the bubble detector due to long vibration time. When detection is required, the bubble detector is installed on the side of the fixed rod 9 to detect the perfusion device 1. The bubble detector uses different signals of ultrasonic refraction, and through control, it is displayed on the computer terminal to determine whether there are air bubbles in the perfusion device 1.

[0052] In this embodiment, the driving pump 16 sets the output parameters through the controller. After starting, it extracts the pre-flushing liquid in the liquid extraction end 15 according to the parameters and inputs it into the first pre-flushing liquid pipe 2 to complete the transportation of the pre-flushing liquid. When the perfusion device 1 is pre-flushed, the pre-flushing liquid flows through the second pre-flushing liquid pipe 3 to the waste liquid bag 17. Among them, through the parameters set by the controller, the driving pump 16 is better controlled to achieve a constant flow rate. After the pre-flushing is completed, the buzzer sounds, and the nurse uses the on-off clip 18 to clamp the first pre-flushing liquid pipe 2 and the second pre-flushing liquid pipe 3 to prevent liquid backflow and also avoid external air from entering the first pre-flushing liquid pipe 2 and the second pre-flushing liquid pipe 3, thereby affecting the pre-flushing result of the perfusion device 1.

[0053] In addition, the parameter setting can be completed according to the actual use, and it should not be limited to a unique fixed parameter.

[0054] As Figure 5 shown, the embodiment of the present invention proposes a method for using a blood perfusion device batch pre-flushing device, including the following steps:

[0055] Step S11, connect a set number of perfusion devices 1;

[0056] Step S12, set the pre-flushing program parameters, such as including the pre-flushing liquid volume, pre-flushing time, pre-flushing flow rate, pre-flushing completion reminder, and alarm parameter settings, etc.;

[0057] Step S13, the driving pump 16 transports the pre-flushing liquid and diverts it to each perfusion device 1;

[0058] Step S14, start the vibration motor 8 to vibrate the perfusion device 1;

[0059] Step S15: Detect whether there is air in the perfusion device 1 through a bubble detector. If there is air, an alarm message is sent in response to the alarm program parameter, and step S14 is resumed according to the alarm message; if there is no air, a pre-flushing end signal is sent in response to the pre-flushing end program parameter.

[0060] Step S16: According to the pre-flushing end signal, start the on-off clamp 18 to block the first pre-flushing liquid pipe 2 and the second pre-flushing liquid pipe 3.

[0061] Among them, the alarm message can adopt a sound alarm or a light alarm.

[0062] The specific setting of the flow parameter of the pre-flushing liquid depends on the actual situation. For example, it can be in the range of 200 - 400 ml / min to achieve a better output water pressure effect of the pre-flushing liquid.

[0063] In summary, by outputting program parameters through the controller, controlling the pre-flushing result prompt, detecting air bubbles in the perfusion device 1, and vibrating the perfusion device 1 to prevent air bubbles from existing in the perfusion device 1, the nurse intervention is reduced, the pre-flushing function of the perfusion device 1 is automatically completed, and the optimal pre-flushing effect is achieved. In addition, the pre-flushing function is completed for multiple perfusion devices 1, the pre-flushing of multiple perfusion devices 1 is achieved, the requirement for large-scale pre-flushing is completed, and the use of human and medical resources is reduced.

[0064] Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and its equivalent technologies, the present invention also intends to include these changes and modifications.

Claims

1. A batch pre-flushing device for a hemoperfusion cartridge, characterized in that, Including: A plurality of perfusion devices, the input end and the output end of each perfusion device can be respectively plugged into a flow distribution plate and a flow collecting plate through connecting pipes, the flow distribution plate is connected to the same liquid end through a first priming liquid pipe, and the flow collecting plate is connected to a waste liquid collecting member through a second priming liquid pipe; The flow distribution plate has an inlet, and a plurality of branches are arranged in the flow distribution plate. One end of each branch is connected to the inlet, and the other end is connected to an insertion port. The inlet is connected to the first priming liquid pipe, and the insertion port of the flow distribution plate is connected to the input end of the perfusion device; The flow collecting plate has an outlet, and a plurality of branches are arranged in the flow collecting plate. One end of each branch is connected to the outlet, and the other end is connected to an insertion port. The outlet is connected to the second priming liquid pipe, and the insertion port of the flow collecting plate is connected to the output end of the perfusion device; Wherein, the materials and pipe diameters of each branch are the same; The perfusion device is connected to a fixing assembly, the fixing assembly includes a fixing rod, a plurality of movable holes are arranged inside the fixing rod, fixing blocks are arranged in the movable holes, and the fixing blocks are detachably connected or fixedly connected to a connecting member, and the connecting member is used for clamping the perfusion device; The connecting member includes a vibrating rod and a clamping element, one end of the vibrating rod is connected to the clamping element, and the other end is connected to the fixing block, and the clamping element is used for clamping the perfusion device; The fixing assembly further includes a transmission rod, and the transmission rod is connected with a vibration motor.

2. The batch pre-flushing device for a hemoperfusion cartridge according to claim 1, characterized in that, A switch is arranged on each branch.

3. The batch pre-flushing device for a hemoperfusion cartridge according to claim 1, wherein, An installation member is arranged on one side of the fixing rod, the installation member is detachably connected with a bubble detector, the input end of the bubble detector is connected to a controller, and the output end faces the perfusion device to detect the air in the perfusion device.

4. The batch pre-rinsing device for a hemoperfusion cartridge according to claim 1, wherein, On-off clamps are arranged on the first priming liquid pipe and the second priming liquid pipe.

5. The method of using the batch pre-flushing device for a hemoperfusion cartridge according to any one of claims 1-4, characterized in that, Including the following steps: Step S11, connect a set number of perfusion devices; Step S12, set the priming program parameters; Step S13, drive a pump to transport the priming liquid and distribute it to each perfusion device; Step S14, start the vibration motor to vibrate the perfusion device; Step S15, detect whether there is air in the perfusion device through the bubble detector. If there is air, an alarm message is sent in response to the alarm program parameters, and return to step S14 according to the alarm message; if not, a priming end signal is sent in response to the priming end program parameters; Step S16, according to the priming end signal, start the on-off clamp to block the first priming liquid pipe and the second priming liquid pipe.

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