Acetylenesulfonamides and their applications

By developing sulfadiazine compounds as GPX4 inhibitors, the shortcomings of existing pancreatic cancer treatment methods have been addressed, achieving effective inhibition and treatment of various tumors, especially pancreatic cancer through the ferroptosis pathway.

CN118496130BActive Publication Date: 2026-05-26JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Filing Date
2023-02-15
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing treatment options for pancreatic cancer are limited. GPX4 inhibitors are insufficient in terms of activity and selectivity, resulting in poor treatment outcomes, and there is a lack of effective new treatment strategies.

Method used

A class of acetylsulamide compounds has been developed as GPX4 inhibitors to inhibit GPX4 activity and induce ferroptosis, thereby treating a variety of tumors, including pancreatic cancer.

Benefits of technology

Sulphine amides have a strong inhibitory effect on GPX4 and exert anti-tumor effects through the ferroptosis pathway. They have significant inhibitory and therapeutic effects on various tumors such as pancreatic cancer, leukemia, and breast cancer.

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Abstract

This invention provides a sulfadiazine amide compound having the structure shown in Formula (I), or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, and its use in the preparation of GPX4 inhibitors, as well as its use in drugs for the prevention and / or treatment of tumors. The sulfadiazine amide compound provided by this invention can act on targets including GPX4, exhibits strong inhibitory activity against GPX4, exerts antitumor effects through the ferroptosis pathway, and has strong inhibitory and therapeutic effects on various tumors, including pancreatic cancer.
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