A non-filling breast augmentation external skin-regenerating oil preparation and its preparation method and application

Abstract

The present invention relates to the technical field of new drug indications, and specifically discloses a non-filling breast augmentation external skin-rejuvenating oil preparation and its preparation method and application. The preparation method of the external skin-rejuvenating oil preparation is as follows: (1) preparing a skin-rejuvenating oil alcohol extract freeze-dried powder: taking astragalus, angelica, epimedium, ginkgo, green peel, frankincense, rhubarb, chicken gizzard, scutellaria, coptis, phellodendron and borneol in a certain weight ratio and adding them together into a container, and then adding an ethanol solution with a volume fraction of 40%-70% to the container, soaking, flash extraction, filtrate concentration, freeze drying to obtain; (2) preparing a skin-rejuvenating oil preparation: dissolving the skin-rejuvenating oil alcohol extract freeze-dried powder and egg yolk lecithin in edible vegetable oil to obtain an oil phase; then dripping the oil phase into the water phase obtained by dissolving Tween 60 and glycerol in ultrapure water, stirring and high-speed shearing, high-pressure homogenization, and obtaining. The external skin-rejuvenating oil preparation of the present invention has the effect of promoting breast fullness and uprightness in a short period of time.

Description

Technical Field

[0001] The invention relates to the technical field of new drug indications, and in particular to a non-filling breast augmentation external skin-regenerating oil preparation, a preparation method and application thereof. Background Art

[0002] The breasts are composed of mammary glands and fat that secrete milk, as well as muscle tissue that supports the breasts. They are the lactation organs that produce breast milk and nourish babies.

[0003] Breast hypoplasia can cause flat and small breasts, or improper maintenance, sagging breasts after breastfeeding or aging can greatly affect women's body beauty and even seriously threaten the harmonious relationship between couples. Therefore, making breasts fuller and taller (in other words, breast augmentation) through various methods has always been the focus and hot spot of women's beauty.

[0004] Currently, breast augmentation mainly includes two types of methods: non-surgical and surgical (also known as breast augmentation). Non-surgical methods: (1) taking estrogen, or applying ointments / essential oils containing estrogen (although effective, it is never recommended); (2) training chest muscles through fitness, which makes the breasts look bigger (safe, but has no actual breast enhancement effect). Surgical methods (need to be performed in a qualified and professional medical beauty center, or the plastic surgery department of a high-level clinical hospital): through surgical methods, certain chemical fillers (such as liquid paraffin, medicinal silicone oil, silicone capsule prosthesis, polyacrylamide hydrogel, double-capsule saline bag, etc.; breast augmentation materials that are scary to think about), biological fillers (such as collagen, gelatin matrix, chitosan gel, hyaluronic acid, etc.; non-autologous materials lead to rejection reactions, which are common and harmful to people) and certain autologous components (such as autologous adipose tissue, autologous adipose granular cells, autologous stem cells, autologous dermal fat flaps, etc.; seemingly harmless, but actually self-mutilation) can be used to quickly fill and make up for the defects and deficiencies of female breasts to achieve the purpose of "breast augmentation" (the short-term effect is good, but in the long run it is a waste of money, hurts people, and even kills people).

[0005] Obviously, the breast augmentation surgery from the earliest use of paraffin wax to the current filling of non-autologous materials and autologous materials is a blood and tears history of women's beauty. Although those constantly updated breast augmentation materials have made up for the visual defects of many women's breasts in a short period of time, in the long run, in addition to the high cost (basically a loss of money), there are also unbearable serious complications (painful suffering), and even make the parties pay an irreparable painful price.

[0006] Therefore, in order to prevent countless women from enduring endless pain for short-term sexual satisfaction, we need to find a healthy method that does not rely on abnormal estrogen supplementation, prostheses or autologous fillings, but rather a safe external application method that can make the breasts naturally fuller in a short period of time. Summary of the invention

[0007] In view of the problem that the above-mentioned prior art lacks non-filling external special medicines for breast enhancement:

[0008] The first object of the present invention is to provide a non-filling external skin-rejuvenating oil preparation that can enlarge breasts in a short period of time. The external skin-rejuvenating oil preparation is obtained by the inventor after substantial adjustments based on the early external skin-rejuvenating oil formula (CN202311321241.1) of the inventor's team in order to solve the problem of small and sagging breasts.

[0009] The second object of the present invention is to provide a method for preparing the above-mentioned external skin-regenerating oil preparation for breast enhancement.

[0010] The third object of the present invention is to provide the medical use of the above-mentioned external skin-regenerating oil preparation for breast enhancement.

[0011] The inventive concept of the present invention is as follows:

[0012] The inventors believe that small or flat breasts are mostly caused by congenital kidney deficiency, acquired spleen and stomach weakness, or liver qi stagnation, which causes qi deficiency and blood stasis, resulting in breasts being dehydrated and difficult to plump; qi deficiency lasts for a long time and is unable to lift, resulting in breast sagging. Combined with the "Huangdi Neijing" points out: "The meridians are the reason why we can decide life and death, treat all kinds of diseases, and adjust deficiency and excess, so they must be unblocked", so the inventors consider the treatment principle of "invigorating qi and activating blood circulation, removing blood stasis and unblocking meridians", based on unblocking local qi and blood meridians, improving breast microcirculation, supplementing the nutrients needed by breast cells, regulating hormone secretion, promoting breast development, and finally achieving full and firm breasts.

[0013] In order to achieve the first purpose, the present invention adopts the following technical measures:

[0014] A skin-enhancing external skin-regenerating oil preparation for breast enhancement, the skin-regenerating oil preparation is a skin-regenerating oil alcohol extract oil-in-water preparation, the solute of the skin-regenerating oil preparation is a skin-regenerating oil alcohol extract freeze-dried powder; wherein the content of the skin-regenerating oil alcohol extract in the skin-regenerating oil alcohol extract oil-in-water preparation is greater than 0 and not greater than 30 mg / ml, preferably not less than 10 mg / ml and not greater than 30 mg / ml, and more preferably 30 mg / ml. The skin-regenerating oil alcohol extract is prepared by alcohol extraction of 12 raw materials in the following weight proportions (preferably, prepared by immersing in an ethanol solution with a volume fraction of 40%-70% for 2-3 hours): 5-30 weight parts of astragalus, 5-30 weight parts of angelica, 5-30 weight parts of epimedium, 5-30 weight parts of ginkgo, 5-30 weight parts of green peel, 5-30 weight parts of frankincense, 5-30 weight parts of rhubarb, 5-30 weight parts of chicken gizzard lining, 5-30 weight parts of scutellaria, 5-30 weight parts of coptis, 5-30 weight parts of phellodendron, and 3-8 weight parts of borneol.

[0015] Furthermore, the preparation method of the lyophilized powder of the alcohol extract of raw skin oil is as follows: dry powders of 11 raw medicinal materials of raw skin oil and borneol are taken in a certain weight ratio and added into a container, and then an ethanol solution with a volume fraction of 40%-70% is added into the container, soaked for 2-3 hours, flash extracted 3-5 times, each time for 5 minutes, concentrated the filtrate, and freeze-dried to obtain the lyophilized powder of the alcohol extract of raw skin oil.

[0016] In order to achieve the second purpose, the present invention adopts the following technical measures:

[0017] A method for preparing the above-mentioned external skin-regenerating oil preparation for breast enhancement, the steps of which are as follows:

[0018] (1) Preparation of freeze-dried powder of alcohol extract of skin-generating oil: 12 raw materials of skin-generating oil are taken in certain weight proportions (the weight proportions of each raw material are: 5-30 weight parts of astragalus, 5-30 weight parts of angelica, 5-30 weight parts of epimedium, 5-30 weight parts of ginkgo, 5-30 weight parts of green peel, 5-30 weight parts of frankincense, 5-30 weight parts of rhubarb, 5-30 weight parts of chicken gizzard lining, 5-30 weight parts of scutellaria, 5-30 weight parts of coptis root, 5-30 weight parts of phellodendron amurense) 30 weight parts, borneol 3-8 weight parts) totaling 500g, except borneol, the remaining drugs are ground (passed through a 200-mesh sieve) and placed in a 10L stainless steel barrel, 3L-7L of ethanol with a volume fraction of 40%-70% is added, soaked for 2-3h, flash extracted 3-5 times, each time for 5min, and the filtered supernatant is quickly concentrated by a multi-stage flash evaporator, and then freeze-dried to obtain the lyophilized powder of the raw skin oil alcohol extract (the yield is 11.7%-13.1%).

[0019] (2) Preparation of skin-regenerating oil preparation: Dissolve the freeze-dried powder of skin-regenerating oil alcohol extract and egg yolk lecithin in edible vegetable oil to prepare an oil phase, and drop the oil phase into the water phase prepared by dissolving Tween 60 and glycerol in ultrapure water at a volume ratio of 1:4, stir and then high-speed shear and high-pressure homogenize to obtain; the zeta potential and particle size distribution of the obtained skin-regenerating oil alcohol extract water-in-oil preparation are uniform; its particle size distribution is 78 to 825 nm, and there is no multiple scattering phenomenon, the average particle size is 255±10 nm; the average zeta potential is -50 mV to -40 mV. Wherein, the edible vegetable oil is selected from at least one of sesame seed oil, coconut oil and olive oil. Preferably, the steps of preparing the skin-regenerating oil preparation in step (2) are:

[0020] 1) Dissolving the freeze-dried powder of the raw skin oil alcohol extract and egg yolk lecithin in edible vegetable oil to prepare an oil phase; the final concentration of the egg yolk lecithin is 6% (W / V; g / ml); 2) Dissolving Tween 60 and glycerol in ultrapure water to prepare an aqueous phase; the final concentration of Tween 60 is 1.2% (V / V); the final concentration of glycerol is 2% (V / V); 3) Under the condition of a 60° C. constant temperature water bath, the oil phase prepared in step 1) is dripped into the aqueous phase prepared in step 2), and stirred at 1200 r / min for 15 min; the volume ratio of the oil phase to the aqueous phase is 1:4; 4) High-speed shearing is performed at 10000 rpm for 2 min, and then high-pressure homogenization is performed at 1000 bar for 6 times to obtain a raw skin oil alcohol extract oil-in-water preparation.

[0021] In order to achieve the third purpose of the present invention, the present invention also adopts the following technical measures:

[0022] The application of the above-mentioned external skin-regenerating oil preparation or the external skin-regenerating oil preparation prepared by the above-mentioned method in the preparation of external breast enhancement drugs, especially in the preparation of non-filling external breast enhancement drugs. The breast enhancement type is small and / or loose.

[0023] The formulation principles of each Chinese medicinal raw material of the present invention are as follows:

[0024] Astragalus, Chinese angelica, epimedium, ginkgo, etc. are the main ingredients that nourish qi, blood and essence; green peel, frankincense, rhubarb, chicken gizzard lining, etc. are the ministers that relieve stagnation and relieve blood stasis; scutellaria, coptis, phellodendron, etc. are the assistants that cool blood and eliminate evil to prevent stagnation; borneol and vegetable oil (use their viscosity to cover the skin, retain moisture in the form of oil film, and prevent dryness) are the envoys. All the medicines work together to improve breast microcirculation, so that nutrients and oxygen can reach mammary cells and fat cells, which can not only quickly relieve breast relaxation and sagging, but also promote breast fullness and uprightness in a short period of time, increase breast elasticity and softness, and ultimately achieve breast augmentation without filling.

[0025] Compared with the prior art, the present invention has the following advantages and effects:

[0026] The results of the study show that the skin-enhancing oil preparation prepared by the present invention has the following advantages and effects after being administered through the skin: (1) It can be applied externally, which is extremely simple to operate and does not cause skin damage (this is incomparable to surgical filling). There is no need to worry about rupture inside the breast and harm to the body as with prostheses or autologous fillings; (2) The drug cost is low, it is non-irritating, has no toxic side effects, and does not pose any health threat to the body caused by breast augmentation of fillers; (3) It has a good breast enhancement effect for women with small breasts or sagging breasts, and the time required is very short; (4) When rubbing the breasts before and after, in addition to the increased fullness and softness, there is no abnormal touch (including hardening of the breasts); (5) In addition to making the breasts naturally fuller, it can also eliminate the discomfort of distension, nodules, etc. during the menstrual period. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 The particle size and potential of the skin-regenerating oil preparations prepared in Examples 1 and 2 are characterized in FIG.

[0028] Figure 2 This is a graph showing the effect of the skin-regenerating oil preparation prepared in Example 1 on smaller breasts.

[0029] Figure 3 This is a graph showing the effect of the skin-regenerating oil preparation prepared in Example 2 on breast sagging. DETAILED DESCRIPTION

[0030] The applicant will further explain the technical solution and application of the present invention in detail below in conjunction with specific embodiments. It should be understood that the following content shall not limit the protection scope of the present invention in any way.

[0031] The dry powders of eleven Chinese medicinal materials used in the embodiments of the present invention, including astragalus, angelica, epimedium, ginkgo, green peel, frankincense, rhubarb, chicken gizzard lining, scutellaria, coptis root, and phellodendron, were all sieved through a 200-mesh sieve.

[0032] Example 1: Preparation and characterization of skin-regenerating oil preparation

[0033] 1) Preparation of skin-regenerating oil preparation

[0034] Preparation of freeze-dried powder of raw skin oil alcohol extract: Take 521g of raw skin oil raw materials (80g each of dry powder of astragalus, angelica, epimedium, and ginkgo, 30g each of dry powder of green peel, frankincense, rhubarb, and chicken gizzard, 20g each of dry powder of scutellaria, coptis, and phellodendron, and 21g of borneol), stir evenly and place in a 10L stainless steel barrel, add 4L of 70v / v% ethanol, soak for 3h, flash extract 3 times, each time for 5min, and quickly concentrate the supernatant filtered three times by a multi-stage flash evaporator, and then freeze-dry to obtain freeze-dried powder of raw skin oil alcohol extract (60.9g).

[0035] Preparation of skin-generating oil preparation: ① Dissolve the freeze-dried powder of skin-generating oil alcohol extract and egg yolk lecithin in sesame seed oil to prepare the oil phase, and the final concentration of egg yolk lecithin is 6% (W / V). ② Dissolve Tween 60 and glycerol in ultrapure water to prepare the water phase, and the final concentration of Tween 60 is 1.2% (V / V), and the final concentration of glycerol is 2% (V / V). ③ Under the condition of a 60°C constant temperature water bath, drop the oil phase into the water phase, stir at 1200r / min for 15min, and the volume ratio of the oil phase to the water phase is 1:4. ④ High-speed shearing at 10000rpm for 2min, and then high-pressure homogenization at 1000bar for 6 times to obtain a skin-generating oil alcohol extract water-in-oil preparation, referred to as a skin-generating oil preparation, and the content of the skin-generating oil alcohol extract in the obtained skin-generating oil preparation is equal to 30mg / ml.

[0036] 2) Characterization of particle size and zeta potential of skin-regenerating oil preparations

[0037] When measuring the particle size of the skin-regenerating oil preparation, the sample was diluted with ultrapure water to make its count rate between 200 and 300 Kcps (1,000 counts per second), and then the particle size and polydispersity index were measured with a laser particle size analyzer at a scattering angle of 90° and a temperature of 25°C. When measuring the zeta potential, the conductivity of the skin-regenerating oil preparation was adjusted to 50 S / cm with a 0.9% (w / w) sodium chloride solution. Figure 1 As shown in (A, B), the particle size of the skin-regenerating oil preparation prepared in Example 1 is mainly distributed in the range of 78 to 825 nm, the average particle size is about 255 nm, and there is no multiple scattering phenomenon; and the zeta potential is evenly distributed, with an average of -47.5 mV.

[0038] Example 2: Preparation and characterization of skin-regenerating oil preparations

[0039] 1) Preparation of skin-regenerating oil preparation

[0040] Preparation of freeze-dried powder of raw skin oil alcohol extract: Take 680g of raw skin oil raw materials (60g each of dry powder of astragalus, angelica, epimedium, ginkgo, green peel, frankincense, rhubarb, chicken gizzard lining, scutellaria, coptis, and phellodendron, 20g of borneol), stir evenly and place in a 10L stainless steel barrel, add 9L of 40v / v% ethanol, soak for 3h, flash extract 5 times, each time for 5min, and quickly concentrate the supernatant filtered five times by a multi-stage flash evaporator, and then freeze-dry to obtain freeze-dried powder of raw skin oil alcohol extract (89.1g).

[0041] Preparation of skin-generating oil preparation: ① Dissolve the freeze-dried powder of skin-generating oil alcohol extract and egg yolk lecithin in olive oil to prepare the oil phase, and the final concentration of egg yolk lecithin is 6% (W / V). ② Dissolve Tween 60 and glycerol in ultrapure water to prepare the water phase, and the final concentration of Tween 60 is 1.2% (V / V), and the final concentration of glycerol is 2% (V / V). ③ Under the condition of a 60°C constant temperature water bath, drop the oil phase into the water phase, stir at 1200r / min for 15min, and the volume ratio of the oil phase to the water phase is 1:4. ④ High-speed shearing at 10000rpm for 2min, and then high-pressure homogenization at 1000bar for 6 times to obtain a skin-generating oil alcohol extract water-in-oil preparation, referred to as a skin-generating oil preparation, and the content of the skin-generating oil alcohol extract in the obtained skin-generating oil preparation is equal to 30mg / ml.

[0042] 2) Characterization of particle size and zeta potential of skin-regenerating oil preparations

[0043] When measuring the particle size of the skin-regenerating oil preparation, the sample was diluted with ultrapure water to make its count rate between 200 and 300 Kcps (1,000 counts per second), and then the particle size and polydispersity index were measured with a laser particle size analyzer at a scattering angle of 90° and a temperature of 25°C. When measuring the zeta potential, the conductivity of the skin-regenerating oil preparation was adjusted to 50 S / cm with a 0.9% (w / w) sodium chloride solution. Figure 1 As shown in (C, D), the particle size of the skin-regenerating oil preparation prepared in Example 2 is mainly distributed in the range of 91 to 712 nm, the average particle size is about 255 nm, and there is no multiple scattering phenomenon; and its zeta potential is evenly distributed, with an average of -46.6 mV.

[0044] Example 3 Effect of the skin-regenerating oil preparation prepared in Example 1 on small breasts

[0045] Volunteer Ms. S, 48 years old, is in good health and has no other skin diseases except that her left breast is too small. Ms. S has been engaged in the light medical beauty industry for nearly 20 years. Because of her asymmetric breast size (the left breast is obviously smaller), her body beauty is seriously affected. Although Ms. S refused breast augmentation surgery, she has tried external breast augmentation many times, but the result was basically ineffective. She started to use the skin-generating oil preparation for external application in mid-January 2024.

[0046] Before the assessment, stand naturally, with your feet shoulder-width apart, shoulders relaxed, upper limbs naturally drooping, and take a clear photo. Then, 2-3 ml of the skin-regenerating oil preparation prepared in Example 1 was dripped onto the left breast, and quickly spread by hand, starting from the bottom of the breast, and in a clockwise direction, gradually approaching the nipple direction, and continuously massaged for 10-15 minutes in a small circle (to ensure that the entire breast is massaged in place; once a day), and then washed. During the application period, personal eating habits and work and rest rules were not deliberately changed.

[0047] The results are as follows Figure 2 As shown in the figure above (before application), the middle figure (40 days after application) and the lower figure (86 days after application), the left breast: (1) the distance between the left and right breast lateral edges increased from 14.8 before application to 15.2 and 15.5 after 40 and 86 days of application, respectively (the length of the green box in the figure is 15.2 and the size of the black mole on the left breast is used as reference); (2) the distance between the left and right breast bottom edges decreased from 0.9 before application to 0.85 and 0.6 after 40 and 86 days of application, respectively (the length of the green box in the figure is 15.2 and the size of the black mole on the left breast is used as reference); (3) the patient said that compared with before application, the left breast after breast augmentation had a greater sense of fullness and softness when rubbing it, but there was no abnormal touch (including hardening of the breast); and there was no more discomfort such as swelling, pain and nodules during menstruation. The above results all indicate that after applying the skin-generating oil preparation externally, the left breast has indeed grown from small to fuller and rounder in comparison with the right breast.

[0048] Example 4 Effect of the skin-regenerating oil preparation prepared in Example 2 on breast sagging

[0049] Volunteer Ms. M, 36 years old, mother of two children (Eldest is 11 years old, Little is 2 years old), has been engaged in the medical beauty industry for nearly ten years; since giving birth, her abdominal stretch marks are very obvious (grey and white, bumpy), and her breasts (and nodules in the left breast, often feel bloated and uncomfortable on weekdays) and abdominal skin are very loose. In the past three years, in order to eliminate the problem of looseness, Ms. S often went to the hospital for consultation and medication, and also frequently visited medical beauty clinics to pursue "green" body shaping, but she spent a lot of money and hardly got the effect she wanted. In early March 2024, she began to use the skin-generating oil preparation for external application.

[0050] Before the assessment, stand naturally, with your feet shoulder-width apart, shoulders relaxed, upper limbs naturally drooping, and take a clear photo. Then, drop 2-3 ml of the skin-regenerating oil preparation prepared in Example 2 on the left and right breasts respectively, and spread it quickly with your hands, starting from the bottom of the breast, and massage in a clockwise direction, gradually approaching the nipple direction, and continue to massage for 10-15 minutes in a small circle (to ensure that the entire breast is massaged in place; once a day), and then wash. During the application period, do not deliberately change your personal eating habits and work and rest routines.

[0051] The results are as follows Figure 3As shown in the figure above (before application), the middle figure (2 days after application, 10 days after application) and the lower figure (20 days after application), it is shown that from before application of the skin-regenerating oil preparation to 20 days of continuous application, the breasts: (1) the distance between the left and right breasts (indicated by the numerical value at the bottom of the inverted "T" in the figure; its size is based on the length of the yellow line at the upper end of the chest, 14.00, and the length of the black line, 0.90; the position reference is the red circle in the middle of the upper end of the chest, which is a black mole of the volunteer) increased from 5.23 before application to 1.33 after application. After 2 days, 10 days and 20 days of application, the breasts were shortened to 5.00, 4.80 and 4.60 respectively; (2) Compared with before application, after 2 days, 10 days and 20 days of application, the breasts became obviously fuller; (3) She also said that compared with before application, after the breasts were rubbed, in addition to the fullness and softness, the feeling of the left nodule gradually disappeared, and there was no abnormal touch (including breast nodules); and there was no discomfort such as swelling, nodules, etc. on weekdays. The above results all indicate that after using the skin-enhancing oil preparation for external application, compared with before application, the breasts are no longer as loose as before, but have been greatly tightened and lifted, and are plump and round.

Claims

1. The use of a skin-regenerating oil preparation in the preparation of a breast-enhancing external medicine, characterized in that: The skin-regenerating oil preparation is a skin-regenerating oil alcohol extract oil-in-water preparation, and the content of the skin-regenerating oil alcohol extract in the skin-regenerating oil alcohol extract oil-in-water preparation is not less than 10 mg / ml and not more than 30 mg / ml; the preparation method of the skin-regenerating oil preparation is: dissolving the freeze-dried powder of the skin-regenerating oil alcohol extract and egg yolk lecithin in edible vegetable oil to prepare an oil phase, and dropping the oil phase into an aqueous phase prepared by dissolving Tween 60 and glycerol in ultrapure water at a volume ratio of 1:4 between the oil phase and the aqueous phase, stirring, high-speed shearing, and high-pressure homogenization to obtain the skin-regenerating oil alcohol extract oil-in-water preparation, whose zeta potential and particle size distribution are uniform; The preparation method of the lyophilized powder of the alcohol extract of the raw skin oil is as follows: the dry powders of 11 raw medicinal materials of the raw skin oil and borneol are respectively added into a container according to a certain weight ratio, and then a 40%-70% ethanol solution by volume fraction is added into the container, and the mixture is soaked for 2-3 hours, and then flash-extracted, the filtrate is concentrated, and freeze-dried to obtain the lyophilized powder of the alcohol extract of the raw skin oil; The 11 raw materials of the skin-regenerating oil are astragalus, angelica, epimedium, ginkgo, green peel, frankincense, rhubarb, chicken's gizzard lining, scutellaria, coptis, and phellodendron; the weight proportions of each raw material and borneol are as follows: 5-30 parts by weight of astragalus, 5-30 parts by weight of angelica, 5-30 parts by weight of epimedium, 5-30 parts by weight of ginkgo, 5-30 parts by weight of green peel, 5-30 parts by weight of frankincense, 5-30 parts by weight of rhubarb, 5-30 parts by weight of chicken's gizzard lining, 5-30 parts by weight of scutellaria, 5-30 parts by weight of coptis, 5-30 parts by weight of phellodendron, and 3-8 parts by weight of borneol; The total mass of the 12 raw materials of the skin-generating oil and the amount of the ethanol solution with a volume fraction of 40%-70% are in the relationship of 500g:3-7L.

2. The use according to claim 1, characterized in that: The edible vegetable oil is selected from at least one of sesame seed oil, coconut oil and olive oil.

3. The use according to claim 1, characterized in that: The content of the alcohol extract of raw skin oil in the oil-in-water preparation of the alcohol extract of raw skin oil is 30 mg / ml.

4. The use according to claim 1, characterized in that: The dry powders of the 11 medicinal materials, including astragalus, angelica, epimedium, ginkgo, green peel, frankincense, rhubarb, chicken gizzard lining, scutellaria, coptis root and phellodendron, are all sieved through a 200-mesh sieve.

5. The use according to claim 1, characterized in that: The preparation method of the skin-regenerating oil preparation is: (1) Preparing freeze-dried powder of alcohol extract of raw skin oil: taking dry powders of 11 raw medicinal materials of raw skin oil and borneol according to a certain weight ratio and adding them into a container, then adding 40%-70% ethanol solution by volume into the container, soaking for 2-3 hours, flash extraction 3-5 times, each time for 5 minutes, concentrating the filtrate, freeze-drying, and obtaining freeze-dried powder of alcohol extract of raw skin oil; (2) Preparation of skin-regenerating oil preparations: 1) Dissolving the freeze-dried powder of the raw skin oil alcohol extract and egg yolk lecithin in edible vegetable oil to prepare an oil phase; the final concentration of the egg yolk lecithin is 6% W / V; 2) Dissolve Tween 60 and glycerol in ultrapure water to prepare an aqueous phase; the final concentration of Tween 60 is 1.2% V / V; the final concentration of glycerol is 2% V / V; 3) In 60 o C constant temperature water bath, drop the oil phase prepared in step 1) into the water phase prepared in step 2), and stir at 1200 r / min for 15 min; the volume ratio of the oil phase to the water phase is 1:4; 4) High-speed shearing was performed at 10,000 rpm for 2 min, and then high-pressure homogenization was performed at 1,000 bar for 6 times to obtain an oil-in-water preparation of the alcohol extract of the raw skin oil.

6. The use according to claim 5, characterized in that: The zeta potential and particle size distribution of the obtained oil-in-water preparation of the alcohol extract of raw skin oil are uniform; its particle size distribution is 78 ~ 825 nm, and there is no multiple scattering phenomenon, the average particle size is 255±10 nm; the average zeta potential is -50 mV~-40 mV.

7. The use according to claim 1, characterized in that: The breast enlargement external medicine is a non-filling breast enlargement external medicine.

8. The use according to claim 1, characterized in that: The breast types described are small and / or sagging.

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