An intelligent operation monitoring system for a sildenafil citrate tablet preparation device

Abstract

The present invention relates to the technical field of preparation device control, and in particular to an intelligent operation monitoring system for a sildenafil citrate tablet preparation device. The system includes an acquisition module, an analysis module, a control module and an early warning module. The present invention ensures the stable operation of the preparation device by real-time monitoring and control of the process of preparing a foam liquid, measures the size of bubbles on the liquid surface by a joint image analysis technology, accurately analyzes the bubble formation rate, intelligently identifies the bubble formation situation, and timely controls the bubble formation rate to ensure that the foam liquid is uniform and the product quality is guaranteed, calculates the real-time density by a joint image analysis technology, and characterizes the stability of the foam structure by the real-time density to obtain a foam liquid that meets the requirements, intelligently monitors the preparation process of the foam liquid, monitors and controls the size, area and formation rate of the bubbles in real time, and adjusts the foam structure stability by controlling the mixing and stirring conditions to improve the product quality and production efficiency.

Description

Technical Field

[0001] The present invention relates to the technical field of preparation device control, and in particular to an intelligent operation monitoring system for a sildenafil citrate tablet preparation device. Background Art

[0002] Sildenafil citrate tablets are oral medications for the treatment of erectile dysfunction (ED). The pharmacological action of sildenafil citrate is that it acts on PDE5, inhibiting the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis into guanylic acid (GMP), thereby increasing the concentration of cGMP, relaxing smooth muscles, allowing blood to flow into the penis, and causing penis swelling.

[0003] At present, the research on sildenafil dosage forms at home and abroad mainly includes oral fast-dissolving films, pills, chewable tablets, sublingual sprays and dry foam tablets; the drying molding technology solves the problem of low bioavailability of tablet forms, but in industrial production, how to control content uniformity is also a hot topic for relevant researchers.

[0004] Patent document with publication number CN109010324B discloses a sildenafil orodispersible film preparation and a preparation method thereof, wherein a flavoring agent, a water-soluble polymer film-forming material and a plasticizer are mixed in a solvent, and then a pharmaceutical active ingredient is added thereto to disperse to obtain a pharmaceutical solution, and then a film-forming treatment is performed to obtain an orodispersible film preparation; it can be seen that the existing sildenafil citrate preparation technology lacks the steps of mixing sildenafil citrate with auxiliary materials to form a foam liquid, drying the foam liquid to obtain foam particles, and then tableting the foam particles and the auxiliary materials to obtain sildenafil citrate tablets, and accurately controlling the formation and quality of bubbles during the mixing and stirring process to avoid uneven size and distribution of bubbles in the foam liquid, making the foam quality unstable, and resulting in uneven content of the sildenafil citrate tablets obtained after final drying and tableting. Summary of the invention

[0005] To this end, the present invention proposes an intelligent operation monitoring system for a sildenafil citrate tablet preparation device, which is used to overcome the problem in the prior art that the size and formation rate of bubbles cannot be monitored in real time, and the stirring speed and the amount of diluent added are adjusted in time to control the size and stability of the bubbles, resulting in unstable foam quality and low quality of the final product.

[0006] To achieve the above object, the present invention provides an intelligent operation monitoring system for a sildenafil citrate tablet preparation device, comprising:

[0007] A collection module, used for collecting continuous liquid surface images of initial mixed solutions in a plurality of intelligent stirrers at a preset collection period;

[0008] An analysis module is used to analyze the continuous liquid surface images of the current acquisition cycle, calculate the real-time formation rate of bubbles according to two adjacent bubble images, compare the standard formation rate with the real-time formation rate to analyze the bubble formation situation, and when determining the foam formation, calculate the real-time density according to the number of bubbles corresponding to the minimum value of the real-time bubble diameter being less than the standard bubble diameter range, and determine the real-time density according to the standard density range to determine whether the target mixed solution is obtained, or adjust the operating state of the intelligent agitator;

[0009] A control module connected to the analysis module, for adjusting stirring and mixing parameters according to the analysis result of the analysis module, wherein the stirring and mixing parameters include a preset stirring speed, a preset addition amount, and a preset addition speed of the diluent;

[0010] The early warning module is used to give an early warning indication when the current stirring speed is greater than the maximum stirring speed.

[0011] Further, the analysis module includes a bubble formation analysis unit, a bubble size analysis unit, a foam formation analysis unit and a foam density analysis unit, wherein:

[0012] The bubble formation analysis unit is used to analyze the bubble formation situation according to the continuous liquid surface images;

[0013] The bubble size analysis unit is used to obtain the maximum diameter deviation value and the real-time bubble diameter according to the real-time liquid surface image, so as to analyze the uniformity and size of the bubbles;

[0014] The foam formation analysis unit is used to determine foam formation when the real-time bubble diameter is smaller than the minimum value of the standard bubble diameter range;

[0015] The foam density analysis unit is used to obtain continuous liquid surface images of the current acquisition cycle for analysis when foam is formed to calculate the real-time density, and to judge the real-time density according to the standard density range to determine whether the preparation of the target mixed solution is completed.

[0016] Further, the bubble formation analysis unit includes a first calculation subunit, a first comparison subunit and a first determination subunit, wherein:

[0017] The first calculation subunit is used to calculate the real-time formation rate according to the continuous bubble image;

[0018] The first comparison subunit is used to compare the real-time forming rate with the standard forming rate to obtain a comparison result;

[0019] The first determination subunit is used to determine the bubble formation situation according to the comparison result.

[0020] Furthermore, the bubble size analysis unit includes a second calculation subunit, a first identification mark subunit, a second comparison subunit and a second determination subunit, wherein:

[0021] The second calculation subunit is used to obtain a real-time liquid surface image of the initial mixed solution to obtain a maximum diameter deviation value;

[0022] The first identification and marking subunit is used to identify and mark the contours of each bubble in the real-time liquid surface image;

[0023] The second comparison subunit compares the standard diameter deviation value with the maximum diameter deviation value to obtain a comparison result;

[0024] The second determination subunit determines the uniformity of the formed bubbles according to the comparison result;

[0025] Wherein, the second determination subunit determines that the formed bubbles are uneven when the maximum diameter deviation value is greater than the standard diameter deviation value.

[0026] Furthermore, the bubble size analysis unit also includes a cause analysis subunit, wherein:

[0027] The cause analysis subunit is used to compare the real-time bubble diameter with the standard bubble diameter range when the maximum diameter deviation value is greater than the standard diameter deviation value, so as to determine the cause of the uneven bubbles and whether to adjust the real-time stirring speed.

[0028] Furthermore, the foam formation analysis unit is used to compare the real-time bubble diameter with the standard bubble diameter range to determine whether foam is formed when the real-time bubble diameter is not within the standard bubble diameter range.

[0029] Furthermore, the foam density analysis unit includes a third calculation subunit, a second identification mark subunit and a third determination subunit, wherein:

[0030] The second identification and marking subunit performs secondary marking on the corresponding bubbles in the real-time liquid surface image;

[0031] The third calculation subunit obtains the percentage of the number of bubbles that have completed secondary marking in each simulation contour to the real-time number of bubbles as real-time density;

[0032] The third determination subunit determines the real-time density according to the standard density range to determine whether the target mixed solution is obtained, or adjusts the operating state of the intelligent stirrer.

[0033] Furthermore, the control module includes an addition control unit, a stirring control unit and a set value control unit, wherein:

[0034] The adding control unit is used to increase the preset adding speed to a first corrected adding speed when the real-time forming rate is greater than the standard forming rate, and to decrease the preset adding speed to a second corrected adding speed when the maximum diameter deviation value is less than or equal to the standard diameter deviation value;

[0035] The stirring control unit is used to adjust the preset stirring speed when the real-time bubble diameter is within the standard bubble diameter range, or when the real-time density is less than the minimum value of the standard density range;

[0036] The set value control unit is used to correct the preset addition amount according to the real-time density when the real-time density is greater than the maximum value of the standard density range.

[0037] Furthermore, the first calculation subunit obtains continuous bubble images of the current acquisition cycle, obtains any bubble image and adjacent bubble images in chronological order, obtains the percentage of the number of newly added bubbles in the adjacent bubble images to the total number of bubbles, and records it as the real-time formation rate.

[0038] Furthermore, the second calculation subunit obtains the real-time liquid surface image, divides the real-time liquid surface image into a number of simulation areas with a grid, calculates the average value of the diameter of the bubbles in each of the simulation areas, obtains a number of unit bubble diameters, adds the unit bubble diameters and divides them by the number of the simulation areas to obtain the real-time bubble diameter, subtracts the unit bubble diameters from the real-time bubble diameter to obtain a number of bubble diameter differences, takes the absolute value of each bubble diameter difference, and selects the value with the largest absolute value as the maximum diameter deviation value.

[0039] Compared with the prior art, the beneficial effects of the present invention are that the stable operation of the preparation device is guaranteed by real-time monitoring and regulation of the process of preparing the foam liquid, the size of the bubbles on the liquid surface is measured by the joint image analysis technology to analyze the bubble formation rate, the bubble formation rate is accurately analyzed and the bubble formation situation is intelligently identified to accurately analyze the bubble formation process, so as to timely control the bubble formation rate, ensure the consistency of the foam liquid and ensure product quality, calculate the real-time density by the joint image analysis technology, and characterize the stability of the foam structure by the real-time density to obtain a foam liquid that meets the requirements, intelligently monitor the preparation process of the foam liquid, monitor and regulate the size, area and formation rate of the bubbles in real time, and adjust the stability of the foam structure by controlling the mixing and stirring conditions to improve product quality and production efficiency.

[0040] Furthermore, by acquiring continuous images and performing statistical analysis on newly added bubbles in adjacent images, the bubble formation speed is intelligently monitored. When the formation speed is high, the diluent addition speed is timely increased to dilute the sildenafil citrate in the solution and reduce the formation of bubbles, thereby achieving control over the formation of bubbles, precisely controlling the preparation process, maintaining stable operation of the device, and ensuring product quality.

[0041] Furthermore, by analyzing the size of the bubbles when determining that the bubbles are uneven, if the real-time bubble diameter is determined to be smaller than the minimum value of the standard bubble diameter range, it means that bubbles with very small diameters have appeared. In this case, it is a process of conversion from bubbles to foams, and the distribution of the foam structure needs to be continuously monitored to determine whether it is necessary to adjust the texture and stability of the foam by controlling the mixing and stirring conditions.

[0042] Furthermore, the real-time density is calculated based on the real-time bubble diameter and compared with the standard density range. If the real-time density is less than the minimum value of the standard density range, indicating that the bubble density in the foam liquid is low, the stirring speed is adjusted to increase the number and density of bubbles so that the real-time density gradually approaches the standard range. If the real-time density is within the standard density range, indicating that the bubble density of the foam liquid is within the ideal range, it is determined that the preparation of the foam liquid is completed. If the real-time density is greater than the maximum value of the standard density range, indicating that the bubble density is too high, the preset addition amount is adjusted according to the real-time density so that the bubble density of the foam liquid prepared in the next batch is within an appropriate range. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 Schematic diagram of the structure of the intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to the embodiment of the present invention;

[0044] Figure 2 It is a structural schematic diagram of an analysis module according to an embodiment of the present invention;

[0045] Figure 3 This is a schematic structural diagram of a bubble formation analysis unit according to an embodiment of the present invention;

[0046] Figure 4 It is a schematic diagram of the structure of the control module according to an embodiment of the present invention. DETAILED DESCRIPTION

[0047] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0048] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0049] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0050] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0051] See also Figure 1 As shown, it is a structural schematic diagram of an intelligent operation monitoring system for a sildenafil citrate tablet preparation device according to an embodiment of the present invention. The present invention provides an intelligent operation monitoring system for a sildenafil citrate tablet preparation device, comprising:

[0052] A collection module, used for collecting continuous liquid surface images of initial mixed solutions in a plurality of intelligent stirrers at a preset collection period;

[0053] An analysis module is used to analyze the continuous liquid surface images of the current acquisition cycle, calculate the real-time formation rate of bubbles according to two adjacent bubble images, compare the standard formation rate with the real-time formation rate to analyze the bubble formation situation, and when determining the foam formation, calculate the real-time density according to the number of bubbles corresponding to the minimum value of the real-time bubble diameter being less than the standard bubble diameter range, and determine the real-time density according to the standard density range to determine whether the target mixed solution is obtained, or adjust the operating state of the intelligent agitator;

[0054] A control module connected to the analysis module, for adjusting stirring and mixing parameters according to the analysis result of the analysis module, wherein the stirring and mixing parameters include a preset stirring speed, a preset addition amount, and a preset addition speed of the diluent;

[0055] The early warning module is used to give an early warning indication when the current stirring speed is greater than the maximum stirring speed.

[0056] The target mixed solution in this embodiment is a foam liquid. The process of preparing the foam liquid is monitored and regulated in real time to ensure the stable operation of the preparation device. The size of the bubbles on the liquid surface is measured by the joint image analysis technology to analyze the bubble formation rate. The bubble formation rate is accurately analyzed to intelligently identify the bubble formation situation to accurately analyze the bubble formation process. The addition rate of the diluent is then regulated to timely control the bubble formation rate, thereby ensuring the consistency of the foam liquid and ensuring product quality. The real-time density is calculated by the joint image analysis technology, and the stability of the foam structure is characterized by the real-time density to obtain a foam liquid that meets the requirements. The preparation process of the foam liquid is intelligently monitored, and the size, area and formation rate of the bubbles are monitored and regulated in real time. The mixing and stirring conditions are controlled to adjust the stability of the foam structure to improve product quality and production efficiency.

[0057] Specifically, the preparation process of sildenafil citrate tablets in this embodiment includes:

[0058] Step S1, preparing sildenafil citrate foam liquid, pouring a surfactant sodium lauryl sulfate solution into an intelligent stirrer in a preset addition amount, then adding 70.24 g of sildenafil citrate, stirring evenly to dissolve it;

[0059] Step S2, preparing a foam liquid; in a mixed layer, mixing maltodextrin and mannitol in a weight ratio of 1:1, stirring evenly, to form a diluent;

[0060] Add the mixed diluent to the sildenafil citrate solution at a preset adding speed, and stir at a preset stirring speed to make it evenly mixed. During the stirring process, the intelligent operation monitoring system performs real-time control to obtain a foam solution;

[0061] Step S3, preparing foam particles, pouring the foam liquid into a vacuum dryer, setting appropriate temperature and pressure conditions, drying until foam particles are obtained, and taking them out for later use;

[0062] Step S4, tableting, mixing the foam particles with other auxiliary materials uniformly to obtain a mixture;

[0063] The mixture is placed in a tablet press and tablets are formed, packaged and labeled according to the required tablet shape and pressure.

[0064] In this embodiment, the preparation process of step S2 is monitored in real time to ensure that the bubbles are evenly distributed in the liquid and the quality of the foam is guaranteed. The preset addition amount is 40g, and the preset addition speed is 10mL / s, which is measured in advance in the experiment. It starts from a slower speed of 1mL / s and then gradually increases the speed until the mixing effect of the bubbles appears. The preset stirring speed is set between 200 rpm and 400 rpm. The temperature in step S3 is between 20°C and 60°C, and the pressure condition is between 0.2bar and 0.5bar. It is selected and adjusted according to the performance of the actual equipment and the actual situation. Other auxiliary materials are composed of 40g of cross-linked sodium carboxymethyl cellulose, 4.76g of magnesium stearate and 95g of lactose. The tablet shape and pressure are not specifically limited as long as they meet the preparation requirements.

[0065] See also Figure 2 , Figure 3 and Figure 4 As shown, Figure 2 It is a structural schematic diagram of an analysis module according to an embodiment of the present invention;

[0066] Figure 3 This is a schematic structural diagram of a bubble formation analysis unit according to an embodiment of the present invention; Figure 4 This is a schematic diagram of the structure of a control module according to an embodiment of the present invention;

[0067] Specifically, a standard formation rate is set in the first determination subunit, the first calculation subunit obtains continuous bubble images of the current acquisition cycle, obtains a bubble image and adjacent bubble images in chronological order, obtains the percentage of the number of newly added bubbles in the adjacent bubble images to the total number of bubbles, and records it as the real-time formation rate, and the first comparison subunit compares the real-time formation rate with the standard formation rate.

[0068] If the real-time formation rate is less than or equal to the standard formation rate, the standard diameter deviation value is compared with the maximum diameter deviation value to analyze whether the initial mixed solution is uniform;

[0069] If the real-time formation rate is greater than the standard formation rate, the addition control unit increases the preset addition rate of the diluent to a first corrected addition rate;

[0070] Wherein, Uc1′=Uc×[1+(Vs−Vb) / Vs], Uc1′ is the first corrected adding speed, Uc is the preset adding speed, Vs is the real-time forming speed, and Vb is the standard forming speed.

[0071] The standard formation rate set in this embodiment indicates the number of bubbles generated per unit time, which is related to the cross-sectional area of ​​the intelligent agitator and the actual processing volume of the reactants. Generally, the standard formation rate is set between 5 and 50 bubbles per second, and is selected and fine-tuned according to actual conditions and product characteristics to ensure the quality and stability of the foam.

[0072] In this embodiment, the threshold segmentation method is used to extract the bubble features in the bubble image, that is, the bubble edge is segmented by using the watershed algorithm, which compares the maximum grayscale value to a peak and the minimum grayscale value to a valley, and realizes the area separated by the peak according to the different grayscale values, so as to process the superimposed bubbles. At the same time, in order to avoid the situation that when the image has more noise and texture, these noises will also be segmented into small basins, thus forming over-segmentation, the limited contrast adaptive histogram equalization is used before segmentation to perform the pre-processing operation of the enhanced image to improve the contrast of the image, avoid the image noise, and improve the accuracy of bubble recognition and processing. By acquiring continuous images and performing statistical analysis on the newly added bubbles in adjacent images, the bubble formation speed is intelligently monitored to accurately analyze the bubble formation process. When the formation speed is large, the diluent addition speed is timely increased to dilute the sildenafil citrate in the solution and reduce the formation of bubbles, so as to control the formation of bubbles, thereby ensuring the consistency of the foam liquid, finely controlling the preparation process, maintaining the stable operation of the device, and ensuring the product quality.

[0073] Specifically, a standard diameter deviation value is set. When it is determined that the real-time formation rate is less than or equal to the standard formation rate, the second calculation subunit obtains the real-time liquid surface image of the initial mixed solution through the acquisition module, and the identification and marking subunit identifies and outlines each bubble in the real-time liquid surface image to obtain the maximum diameter deviation value, and compares the standard diameter deviation value with the maximum diameter deviation value.

[0074] If the maximum diameter deviation value is greater than the standard diameter deviation value, the second determination subunit determines that the formed bubbles are uneven, and compares the real-time bubble diameter with the standard bubble diameter range to analyze the cause;

[0075] If the maximum diameter deviation value is less than or equal to the standard diameter deviation value, the second determination subunit determines that the bubbles formed are uniform, and the addition control unit reduces the preset addition speed of the diluent to a second corrected addition speed;

[0076] Among them, Uc2'=Uc×[1-(ΔRb-ΔRmax) / ΔRb], Uc2' is the second corrected addition speed, Uc is the preset addition speed, ΔRmax is the maximum diameter deviation value, and ΔRb is the standard diameter deviation value.

[0077] By calculating the maximum deviation when the formation rate is low, the standard diameter deviation value is compared with the maximum diameter deviation value to accurately analyze whether the size of the bubbles is uniform. If the maximum diameter deviation value is greater than the standard diameter deviation value, it means that larger bubbles appear, resulting in uneven bubble formation. If the maximum diameter deviation value is determined to be less than or equal to the standard diameter deviation value, it means that the size of the bubbles formed is within the standard range, that is, the bubbles formed are uniform. At this time, the formation rate is low, but it does not cause unevenness. Therefore, by reducing the concentration of diluent added, the formation of bubbles is promoted and the efficiency is improved.

[0078] Specifically, a standard bubble diameter range is set. When the maximum diameter deviation value is greater than the standard diameter deviation value, the cause analysis subunit compares the real-time bubble diameter with the standard bubble diameter range.

[0079] If the real-time bubble diameter is not within the standard bubble diameter range, the bubble sizes will be compared;

[0080] If the real-time bubble diameter is within the standard bubble diameter range, the cause analysis subunit determines that the unevenness is caused by a low bubble formation rate, and the stirring control unit increases the preset stirring speed to a first corrected stirring speed;

[0081] Wherein, Qc1'=Qc×[1+(Rmax-Rs) / Rmax], Qc1' is the first corrected stirring speed, Qc is the preset stirring speed, Rs is the real-time bubble diameter, and Rmax is the maximum value of the standard bubble diameter range.

[0082] By analyzing the reasons for uneven bubble formation, if it is determined that the real-time bubble diameter is not within the standard bubble diameter range, it means that there may be bubble aggregation, resulting in larger bubble diameters in these areas and smaller bubble diameters in other areas, which manifests as an overall unstable real-time bubble diameter. It may also be that the uneven stirring process leads to uneven bubble distribution, making the bubble diameters in some areas larger and the bubble diameters in other areas smaller, resulting in instability in the real-time bubble diameter. In this case, it is necessary to continue to analyze the bubble diameter to continuously monitor the changes in the bubble diameter to ensure that the bubble size remains within the standard range, and adjust the stirring speed in time to maintain stability. If the real-time bubble diameter is determined to be within the standard bubble diameter range, it means that there are bubbles with a large degree of deviation, but the average bubble size is within the standard range. This is caused by a low formation rate, so increase the stirring speed to speed up the bubble formation rate so that the bubbles reach the standard size range faster.

[0083] In this embodiment, the standard bubble diameter range is a suitable bubble size range set according to product requirements. The standard bubble diameter range is composed of a standard bubble diameter Rb and a standard diameter deviation value ΔRb. The standard bubble diameter range is (Rb-ΔRb, Rb+ΔRb). The standard diameter deviation value is set between 3% and 10% of the standard bubble diameter. The standard bubble diameter can be set within the range of 0.1 mm to 0.5 mm, and is selected and adjusted according to the specific product requirements and application scenarios to ensure that the quality of the final foam liquid and foam particles meets the expected standards.

[0084] Specifically, when the real-time bubble diameter is not within the standard bubble diameter range, the real-time bubble diameter is compared with the standard bubble diameter range.

[0085] If the real-time bubble diameter is less than the minimum value of the standard bubble diameter range, the foam formation analysis unit determines that foam is formed and calculates the real-time density for analysis;

[0086] If the real-time bubble diameter is greater than the maximum value of the standard bubble diameter range, the stirring control unit increases the preset stirring speed to a second corrected stirring speed;

[0087] Wherein, Qc2'=Qc×[1+(Rs-Rmax) / Rs], Qc2' is the second corrected stirring speed, Qc is the preset stirring speed, Rs is the real-time bubble diameter, and Rmax is the maximum value of the standard bubble diameter range.

[0088] By analyzing the size of the bubbles when determining that the bubbles are uneven, if the real-time bubble diameter is determined to be smaller than the minimum value of the standard bubble diameter range, it means that bubbles with very small diameters have appeared. In this case, it is a process of conversion from bubbles to foams. It is necessary to continuously monitor the distribution of the foam structure to determine whether it is necessary to adjust the texture and stability of the foam by controlling the mixing and stirring conditions.

[0089] Specifically, a standard density range of bubbles is set. When it is determined that the real-time bubble diameter is smaller than the minimum value of the standard bubble diameter range, the second identification and marking subunit performs secondary marking on the corresponding bubbles in the real-time liquid surface image. The third calculation subunit obtains the percentage of the number of bubbles that have completed secondary marking in each simulation contour and the real-time number of bubbles as the real-time density. The real-time density is compared with the standard density range.

[0090] If the real-time density is less than the minimum value of the standard density range, the stirring control unit increases the current stirring speed to obtain the current stirring speed, compares the current stirring speed with the maximum stirring speed, and issues an early warning indication when the current stirring speed is greater than the maximum stirring speed;

[0091] If the real-time density is within the standard density range, it is determined that the preparation of the foam liquid is completed;

[0092] If the real-time density is greater than the maximum value of the standard density range, the set value control unit corrects the preset addition amount of the surfactant according to the real-time density to a corrected addition amount;

[0093] Among them, Qs'=Qc×[1+(Wmin-Ws) / Wmin], Qs' is the current stirring speed, Qc is the preset stirring speed, Ws is the real-time density, and Wmin is the minimum value of the standard density range;

[0094] Ac'=Ac×[1-(Ws-Wmax) / Ws], Ac' is the corrected addition amount, Ac is the preset addition amount, Ws is the real-time density, and Wmax is the maximum value of the standard density range.

[0095] The standard density range in this embodiment represents the density threshold of the foam structure. If the real-time density is within the standard density range, it means that the foam density meets the requirements. The set value is related to the particle size requirement of the foam particles. If the particle size requirement of the foam particles is smaller, that is, a denser foam structure needs to be formed, then the standard density setting value is larger. On the contrary, if the particle size requirement of the foam particles is larger, that is, a looser foam structure needs to be formed, then the standard density setting value is lower. Generally, the standard density is set between 80% and 90%, and is selected and adjusted according to actual process requirements.

[0096] The real-time density is calculated based on the real-time bubble diameter and compared with the standard density range to intelligently monitor the preparation process of the foam liquid. If the real-time density is less than the minimum value of the standard density range, it means that the bubble density in the foam liquid is low. The stirring speed is adjusted to increase the number and density of bubbles so that the real-time density gradually approaches the standard range. If the real-time density is within the standard density range, it means that the bubble density of the foam liquid is within the ideal range, and the preparation of the foam liquid is determined to be completed. If the real-time density is greater than the maximum value of the standard density range, it means that the bubble density is too high. The preset addition amount is adjusted according to the real-time density so that the bubble density of the next batch of foam liquid prepared is within an appropriate range.

[0097] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0098] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An intelligent operation monitoring system for a sildenafil citrate tablet preparation device, characterized in that: include, An acquisition module, used to capture images of the surface of the initial mixed solution in the intelligent stirrer at a preset acquisition cycle to obtain corresponding continuous liquid surface images; An analysis module is used to analyze the continuous liquid surface images of the current acquisition cycle, calculate the real-time formation rate of bubbles according to two adjacent bubble images, compare the standard formation rate with the real-time formation rate to analyze the bubble formation situation, and when determining the foam formation, calculate the real-time density according to the number of bubbles corresponding to the minimum value of the real-time bubble diameter being less than the standard bubble diameter range, and determine the real-time density according to the standard density range to determine whether the target mixed solution is obtained, or adjust the operating state of the intelligent agitator; A control module connected to the analysis module, for adjusting stirring and mixing parameters according to the analysis result of the analysis module, wherein the stirring and mixing parameters include a preset stirring speed, a preset addition amount, and a preset addition speed of the diluent; An early warning module is used to issue an early warning indication when the current stirring speed is greater than the maximum stirring speed; The analysis module includes a bubble formation analysis unit, a bubble size analysis unit, a foam formation analysis unit and a foam density analysis unit, wherein: The bubble formation analysis unit is used to analyze the bubble formation situation according to the continuous liquid surface image; The bubble size analysis unit is used to obtain the maximum diameter deviation value and the real-time bubble diameter according to the real-time liquid surface image, so as to analyze the uniformity and size of the bubbles; The foam formation analysis unit is used to determine foam formation when the real-time bubble diameter is smaller than the minimum value of the standard bubble diameter range; The foam density analysis unit is used to obtain continuous liquid surface images of the current acquisition cycle for analysis when foam is formed to calculate the real-time density, and to judge the real-time density according to the standard density range to determine whether the preparation of the target mixed solution is completed.

2. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 1, characterized in that: The bubble formation analysis unit includes a first calculation subunit, a first comparison subunit and a first determination subunit, wherein: The first calculation subunit is used to calculate the real-time formation rate according to the continuous bubble image; The first comparison subunit is used to compare the real-time forming rate with the standard forming rate to obtain a comparison result; The first determination subunit is used to determine the bubble formation situation according to the comparison result.

3. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 1, characterized in that: The bubble size analysis unit includes a second calculation subunit, a first identification mark subunit, a second comparison subunit and a second determination subunit, wherein: The second calculation subunit is used to obtain a real-time liquid surface image of the initial mixed solution to obtain a maximum diameter deviation value; The first identification and marking subunit is used to identify and mark the contours of each bubble in the real-time liquid surface image; The second comparison subunit compares the standard diameter deviation value with the maximum diameter deviation value to obtain a comparison result; The second determination subunit determines the uniformity of the formed bubbles according to the comparison result; Wherein, the second determination subunit determines that the formed bubbles are uneven when the maximum diameter deviation value is greater than the standard diameter deviation value.

4. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 3, characterized in that: The bubble size analysis unit also includes a cause analysis subunit, wherein: The cause analysis subunit is used to compare the real-time bubble diameter with the standard bubble diameter range when the maximum diameter deviation value is greater than the standard diameter deviation value, so as to determine the cause of the uneven bubbles and whether to adjust the real-time stirring speed.

5. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 1, characterized in that: The foam formation analysis unit is used to compare the real-time bubble diameter with the standard bubble diameter range to determine whether foam is formed when the real-time bubble diameter is not within the standard bubble diameter range.

6. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 1, characterized in that: The foam density analysis unit includes a third calculation subunit, a second identification mark subunit and a third determination subunit, wherein: The second identification and marking subunit performs secondary marking on the corresponding bubbles in the real-time liquid surface image; The third calculation subunit obtains the percentage of the number of bubbles that have completed secondary marking in each simulation contour to the real-time number of bubbles as real-time density; The third determination subunit determines the real-time density according to the standard density range to determine whether the target mixed solution is obtained, or adjusts the operating state of the intelligent stirrer.

7. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 1, characterized in that: The control module includes an addition control unit, a stirring control unit and a set value control unit, wherein: The adding control unit is used to increase the preset adding speed to a first corrected adding speed when the real-time forming rate is greater than the standard forming rate, and to decrease the preset adding speed to a second corrected adding speed when the maximum diameter deviation value is less than or equal to the standard diameter deviation value; The stirring control unit is used to adjust the preset stirring speed when the real-time bubble diameter is within the standard bubble diameter range, or when the real-time density is less than the minimum value of the standard density range; The set value control unit is used to correct the preset addition amount according to the real-time density when the real-time density is greater than the maximum value of the standard density range.

8. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 2, characterized in that: The first calculation subunit obtains the continuous bubble image of the current acquisition cycle, obtains any bubble image and adjacent bubble images in chronological order, obtains the percentage of the number of newly added bubbles in the adjacent bubble images to the total number of bubbles, and records it as the real-time formation rate.

9. The intelligent operation monitoring system of the sildenafil citrate tablet preparation device according to claim 3, characterized in that: The second calculation subunit obtains the real-time liquid surface image, divides the real-time liquid surface image into a number of simulation areas with a grid, calculates the average value of the diameter of the bubbles in each simulation area, obtains a number of unit bubble diameters, adds the unit bubble diameters and divides them by the number of simulation areas to obtain the real-time bubble diameter, subtracts each unit bubble diameter from the real-time bubble diameter to obtain a number of bubble diameter differences, takes the absolute value of each bubble diameter difference, and selects the value with the largest absolute value as the maximum diameter deviation value.

Images