Risk assessment based high level pathogen laboratory air cycle unit

Abstract

The application is a circulating air conditioning system for high-level pathogenic microorganism laboratory based on risk assessment, characterized in that: an air supply air treatment unit is arranged on an air supply pipeline, an air exhaust unit is arranged on an air exhaust pipeline, the air supply pipeline is communicated with the air exhaust pipeline through a sterilization bypass air pipeline, the sterilization bypass air pipeline is communicated with one end of a return air pipeline, the other end of the return air pipeline is communicated with an inlet end of the air supply pipeline, the inlet end of the air supply pipeline is further provided with a fresh air bypass air pipeline, air supply closed valves and air exhaust closed valves are respectively arranged in a working room, the air supply closed valves are communicated with the air supply air treatment unit through the air supply pipeline, the air supply closed valves control the air volume entering the working room, the air exhaust closed valves are communicated with the air exhaust unit through the air exhaust pipeline, and the air exhaust closed valves control the air volume exhausted from the working room. The application realizes the switching of the circulating air of the ventilation air conditioning system and the full fresh air system, guarantees the invariability of the sterilization system, ensures that the risk is within an acceptable range, and makes the indoor air quality meet the requirements.

Description

TECHNICAL FIELD

[0001] The present application relates to a circulating air conditioning system for high-level pathogenic microorganism laboratory based on risk assessment. BACKGROUND

[0002] High-level biosafety facilities play a crucial role in ensuring biological safety. They are not only a safe guarantee for the study of highly pathogenic pathogenic microorganisms, but also a key facility for responding to the threat of new emerging infectious diseases, reflecting the national biological defense capability and overall security level. China started late in the construction and standardization of biological safety laboratories, resulting in more stringent requirements for ventilation and air conditioning systems and indoor environmental parameters during the initial construction period to accelerate implementation. At the same time, the function of high-level pathogenic microorganism laboratories determines that the main direction of controlling biological safety risks is to focus on how to ensure the biological safety of the laboratory and avoid cross-contamination. However, there is relatively little research on energy saving during laboratory operation. High-level pathogenic microorganism laboratory ventilation and air conditioning systems usually operate with fresh air. For enterprises with high-level biosafety facilities, reducing costs is not only a response to the needs of national policies, but also a key measure to effectively improve the competitiveness of enterprises. To effectively reduce operating costs, some domestic biological safety laboratories use variable air volume operation and heat recovery devices and other energy-saving technical measures. Although these measures save energy to some extent, the overall effect is not obvious, and it is urgent to research and explore more effective energy-saving methods under the premise of ensuring biological safety to promote the efficient and sustainable use of laboratory energy. According to the comparative analysis of domestic and foreign standards and guidelines in the field of biological safety laboratory construction, it is found that circulating air is allowed in the ventilation and air conditioning systems of foreign high-level biosafety laboratories, with the requirement that return air must be filtered by HEPA and can only be returned to the original area to ensure that cross-contamination does not occur. China explicitly requires the use of fresh air and does not allow the use of circulating air. This requirement is more in line with the national conditions at the time, but as China's biological safety laboratory protection technology continues to progress and develop, it is necessary to further explore and research the possibility of using circulating air in laboratories to effectively promote the energy saving and carbon reduction policy in the new era. SUMMARY

[0003] The application is a circulating air conditioning system for high-level pathogenic microorganism laboratory based on risk assessment, which breaks the traditional all-fresh air conditioning system and control mode, realizes the safe operation condition of the circulating air conditioning system based on biological risk assessment, and provides the best practice solution for promoting the realization of the national double carbon strategy target.

[0004] In order to achieve the above-mentioned purpose, the technical scheme adopted by the application is:

[0005] A circulating air conditioning system for high-level pathogenic microorganism laboratory based on risk assessment, characterized in that: an air supply pipeline is provided with an air supply air treatment unit, an air exhaust pipeline is provided with an air exhaust unit, the air supply pipeline is communicated with the air exhaust pipeline through a disinfection bypass air pipeline, one end of the disinfection bypass air pipeline is communicated with a return air pipeline, the other end of the return air pipeline is communicated with the inlet end of the air supply pipeline, and a fresh air bypass air pipeline is further arranged at the inlet end of the air supply pipeline.

[0006] Air supply and exhaust closed valves are respectively arranged in the working room, the air supply closed valve is communicated with the air supply air treatment unit through the air supply pipeline, the air supply closed valve controls the air volume entering the working room, the air exhaust closed valve is communicated with the air exhaust unit through the air exhaust pipeline, the air exhaust closed valve controls the air volume exhausted from the working room, a variable air volume valve is arranged at the inlet end of the air supply closed valve for controlling the air volume entering the working room, and a variable air volume valve is arranged at the outlet end of the air exhaust closed valve for controlling the air volume exhausted from the working room.

[0007] A sixth closed valve and a first adjusting valve are respectively arranged at the inlet end of the air supply air treatment unit for controlling the air volume entering the air supply air treatment unit, a first closed valve and a fourth adjusting valve are respectively arranged at the outlet end of the air supply air treatment unit for controlling the air volume supplied by the air supply air treatment unit, a third closed valve and a third adjusting valve are respectively arranged at the outlet end of the air exhaust pipeline for controlling the air volume exhausted by the air exhaust unit, a second closed valve is arranged on the disinfection bypass air pipeline for controlling the opening and closing of the pipeline, a fourth closed valve and a second adjusting valve are respectively arranged on the return air pipeline for adjusting the proportion of return air, and a fifth closed valve and a manual adjusting valve are arranged on the fresh air bypass air pipeline for controlling the opening and closing of the pipeline.

[0008] The first closed valve, the second closed valve, the third closed valve, the fourth closed valve, the fifth closed valve and the sixth closed valve are respectively connected with a control system signal, and the control system controls opening and closing respectively;

[0009] The first regulating valve, the second regulating valve, the third regulating valve and the fourth regulating valve are respectively connected with the control system signal, and the control system controls opening degree respectively;

[0010] The control system controls opening degree of the first regulating valve, the second regulating valve and the third regulating valve through monitoring signals of the carbon dioxide concentration detector and the online dust particle counter received, for automatically adjusting indoor air quality;

[0011] The control system is also respectively connected with the air supply air handling unit and the exhaust fan unit signal for controlling air supply and exhaust.

[0012] The circulating air conditioning system of the high-level pathogenic microorganism laboratory based on risk assessment, wherein the working room comprises a changing room, a forced shower room, a buffer room and an isolation aisle, and the isolation aisle is provided with a carbon dioxide concentration detector and an online dust particle counter.

[0013] A control mode of the circulating air conditioning system of the high-level pathogenic microorganism laboratory based on risk assessment, characterized in that:

[0014] When the control mode is a fresh air mode, the air supply air handling unit and the exhaust fan unit are started, the first closed valve, the third closed valve and the sixth closed valve are opened, the second closed valve, the fourth closed valve and the fifth closed valve are closed, the first regulating valve, the third regulating valve and the fourth regulating valve are respectively adjusted to 100% opening state, the second regulating valve is adjusted to 0% closing state, and the air in the working room is always kept as fresh air;

[0015] When the control mode is a circulating air mode, the air supply air handling unit and the exhaust fan unit are started, the first closed valve, the third closed valve, the fourth closed valve and the fifth closed valve are opened, the second closed valve and the sixth closed valve are closed, the first regulating valve is adjusted to 20% opening state, the second regulating valve is adjusted to 80% opening state, the third regulating valve is adjusted to 20% opening state, the fourth regulating valve is adjusted to 100% opening state, and the air in the working room circulates in a state of 20% fresh air and 80% return air;

[0016] When the laboratory runs normally in the circulating air mode, the self-control is based on risk assessment, and when biological safety hidden danger or risk occurs in the laboratory, the laboratory is automatically switched to the fresh air mode, and the working room can ensure a negative pressure state during the switching process, meeting relevant requirements.

[0017] When the control mode is the disinfection mode, it is divided into three stages of circulation, standing and replacement.

[0018] When in the circulation stage, the air supply air handling unit is closed, the air exhaust unit is started, the running frequency of the air exhaust unit is set to 40Hz, the parameter is set to a circulation time of 300 minutes, the second closed valve is opened, the first closed valve, the third closed valve, the fourth closed valve, the fifth closed valve and the sixth closed valve are closed, the first regulating valve, the second regulating valve, the third regulating valve and the fourth regulating valve are adjusted to a closed state of 0%, and the disinfection gas in the working room is circulated.

[0019] When in the standing stage, the air supply air handling unit is closed, the air exhaust unit is started, the running frequency of the air exhaust unit is set to 40Hz, the parameter is set to a standing time of 120 minutes, the second closed valve is opened, the first closed valve, the third closed valve, the fourth closed valve, the fifth closed valve and the sixth closed valve are closed, the first regulating valve, the second regulating valve, the third regulating valve and the fourth regulating valve are adjusted to a closed state of 0%, and the disinfection gas in the working room is standing.

[0020] When in the replacement stage, the air supply air handling unit is closed, the air exhaust unit is started, the running frequency of the air exhaust unit is set to 40Hz, the parameter is set to a replacement time of 240 minutes, the first closed valve, the third closed valve, the fourth closed valve and the fifth closed valve are opened, the second closed valve and the sixth closed valve are closed, the first regulating valve, the third regulating valve and the fourth regulating valve are adjusted to an open state of 100%, the second regulating valve is adjusted to a closed state of 0%, the disinfection gas in the working room is exhausted through the air exhaust unit, and the working room is replaced with fresh air.

[0021] The application has the beneficial effects that the energy saving and carbon reduction operation of the circulating air conditioning system of the high-level pathogenic microorganism laboratory based on risk assessment is realized, the circulating air and the full fresh air system of the ventilation and air conditioning system are automatically switched, the disinfection working condition of the ventilation system is unchanged, the biological safety risk is ensured to be within an acceptable range, and the indoor air quality is automatically controlled to meet the requirements. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 It is a structural diagram of the circulating air conditioning system of the high-level pathogenic microorganism laboratory based on risk assessment.

[0023] Explanation of reference signs: 1 - supply air handling unit; 2 - exhaust air handling unit; 3 - supply air duct; 4 - exhaust air duct; 5 - sterilization bypass air duct; 6 - return air duct; 7 - fresh air bypass air duct; 8 - first closed valve; 9 - second closed valve; 10 - third closed valve; 11 - fourth closed valve; 12 - fifth closed valve; 13 - sixth closed valve; 14 - first regulating valve; 15 - second regulating valve; 16 - third regulating valve; 17 - fourth regulating valve; 18 - supply air closed valve; 19 - exhaust air closed valve; 20 - supply air variable air volume valve; 21 - exhaust air variable air volume valve; 22 - workroom; 23 - carbon dioxide concentration detector; 24 - online dust particle counter. DETAILED DESCRIPTION

[0024] As Figure 1 shown in a high-level pathogenic microorganism laboratory circulating air conditioning system based on risk assessment, characterized in that: the supply air duct 3 is provided with a supply air handling unit 1, the exhaust air duct 4 is provided with an exhaust air handling unit 2, the supply air duct 3 is communicated with the exhaust air duct 4 through the sterilization bypass air duct 5, the sterilization bypass air duct 5 is communicated with one end of the return air duct 6, the other end of the return air duct 6 is communicated with the inlet end of the supply air duct 3, and the inlet end of the supply air duct 3 is further provided with a fresh air bypass air duct 7.

[0025] The workroom 22 includes a changing room, a compulsory shower room, a buffer room and an isolation walkway, the isolation walkway is provided with a carbon dioxide concentration detector 23 and an online dust particle counter 24, the carbon dioxide concentration in the isolation walkway is monitored through the carbon dioxide concentration detector 23, and then the circulating air ratio of the ventilation and air conditioning system is controlled, the dust particles in the isolation walkway are monitored through the online dust particle counter 24, and then the air change frequency in the room is determined, the air and the object surface in each workroom 22 are sampled periodically, the concentration of indoor pathogenic microorganisms is monitored periodically by using a real-time fluorescent quantitative PCR detection method, and it is ensured that there is no pollutant exposure in the room.

[0026] The supply air closed valve 18 and the exhaust air closed valve 19 are respectively arranged in each workroom 22, the supply air closed valve 18 is communicated with the supply air handling unit 1 through the supply air duct 3, the supply air closed valve 18 controls the air volume entering the workroom 22, the inlet end of the supply air closed valve 18 is provided with a supply air variable air volume valve 20 for controlling the air volume entering the workroom 22, the exhaust air closed valve 19 is communicated with the exhaust air handling unit 2 through the exhaust air duct 4, the exhaust air closed valve 19 controls the air volume discharged from the workroom 22, and the outlet end of the exhaust air closed valve 19 is provided with an exhaust air variable air volume valve 21 for controlling the air volume discharged from the workroom 22.

[0027] The inlet end of the air supply air handling unit 1 is respectively provided with a sixth closed valve 13 and a first regulating valve 14 for controlling the air volume entering the air supply air handling unit 1, the outlet end of the air supply air handling unit 1 is respectively provided with a first closed valve 8 and a fourth regulating valve 17 for controlling the air volume sent by the air supply air handling unit 1, the outlet end of the exhaust air duct 4 is respectively provided with a third closed valve 10 and a third regulating valve 16 for controlling the air volume discharged by the exhaust air handling unit 2, the disinfection bypass air duct 5 is provided with a second closed valve 9 for controlling the opening and closing of the duct, the return air duct 6 is respectively provided with a fourth closed valve 11 and a second regulating valve 15 for adjusting the proportion of return air, and the fresh air bypass air duct 7 is provided with a fifth closed valve 12 and a manual regulating valve for controlling the opening and closing of the duct.

[0028] The first closed valve 8, the second closed valve 9, the third closed valve 10, the fourth closed valve 11, the fifth closed valve 12 and the sixth closed valve 13 are respectively connected with a control system signal, the control system controls the opening and closing, the first regulating valve 14, the second regulating valve 15, the third regulating valve 16 and the fourth regulating valve 17 are respectively connected with the control system signal, the control system controls the opening degree, the control system controls the opening degree of the first regulating valve 14, the second regulating valve 15 and the third regulating valve 16 through the monitoring signals of the received carbon dioxide concentration detector 23 and the online dust particle counter 24, for automatically adjusting the indoor air quality, and the control system is also connected with the air supply air handling unit 1 and the exhaust air handling unit 2 respectively for controlling the air supply and exhaust.

[0029] A control mode of a circulating air conditioning system of a high-level pathogen laboratory based on risk assessment, characterized in that:

[0030] When the control mode is the all fresh air mode, the air supply air handling unit 1 and the exhaust air handling unit 2 are started, the first closed valve 8, the third closed valve 10 and the sixth closed valve 13 are opened, the second closed valve 9, the fourth closed valve 11 and the fifth closed valve 12 are closed, the first regulating valve 14, the third regulating valve 16 and the fourth regulating valve 17 are respectively adjusted to 100% of the opening state, the second regulating valve 15 is adjusted to 0% of the closed state, and the air in the workroom 22 is always kept as all fresh air;

[0031] When the control mode is the circulating air mode, the air supply air handling unit 1 and the air exhaust unit 2 are started, the first closed valve 8, the third closed valve 10, the fourth closed valve 11 and the fifth closed valve 12 are opened, the second closed valve 9 and the sixth closed valve 13 are closed, the first regulating valve 14 is adjusted to an opening state of 20%, the second regulating valve 15 is adjusted to an opening state of 80%, the third regulating valve 16 is adjusted to an opening state of 20%, the fourth regulating valve 17 is adjusted to an opening state of 100%, and the air in the workroom 22 circulates in a state of new air 20% and return air 80%;

[0032] When the laboratory is normally operated in the circulating air mode, the self-control is based on risk assessment, and when biological safety hidden dangers or risks occur in the laboratory, the laboratory is automatically switched to the full fresh air operation mode. During the switching process, the workroom 22 can ensure a negative pressure state to meet the relevant requirements.

[0033] When the control mode is the disinfection mode, it is divided into three stages of circulation, standing and replacement.

[0034] When in the circulation stage, the air supply air handling unit 1 is closed, the air exhaust unit 2 is started, the operating frequency of the air exhaust unit 2 is set to 40 Hz, the parameter is set to a circulation time of 300 minutes, the second closed valve 9 is opened, the first closed valve 8, the third closed valve 10, the fourth closed valve 11, the fifth closed valve 12 and the sixth closed valve 13 are closed, the first regulating valve 14, the second regulating valve 15, the third regulating valve 16 and the fourth regulating valve 17 are adjusted to a closed state of 0%, and the disinfection gas in the workroom 22 circulates.

[0035] When in the standing stage, the air supply air handling unit 1 is closed, the air exhaust unit 2 is started, the operating frequency of the air exhaust unit 2 is set to 40 Hz, the parameter is set to a standing time of 120 minutes, the second closed valve 9 is opened, the first closed valve 8, the third closed valve 10, the fourth closed valve 11, the fifth closed valve 12 and the sixth closed valve 13 are closed, the first regulating valve 14, the second regulating valve 15, the third regulating valve 16 and the fourth regulating valve 17 are adjusted to a closed state of 0%, and the disinfection gas in the workroom 22 stands.

[0036] When in the replacement stage, the air supply air handling unit 1 is closed, the air exhaust unit 2 is started, the air exhaust unit 2 is set to a frequency of 40 Hz, the parameter is set to a replacement time of 240 minutes, the first closed valve 8, the third closed valve 10, the fourth closed valve 11 and the fifth closed valve 12 are opened, the second closed valve 9 and the sixth closed valve 13 are closed, the first regulating valve 14, the third regulating valve 16 and the fourth regulating valve 17 are adjusted to an open state of 100%, the second regulating valve 15 is adjusted to a closed state of 0%, the sterilization gas in the workroom 22 is exhausted by the air exhaust unit 2, and the workroom 22 is replaced with fresh air.

[0037] The above description is only illustrative and not restrictive, and those skilled in the art understand that many modifications, changes or equivalents can be made without departing from the spirit and scope defined by the claims, and all of them will fall within the protection scope of the present application.

Claims

1. A risk assessment based, high level pathogen laboratory, air cycle air conditioning system, characterized by: The air supply pipeline (3) is provided with an air supply air handling unit (1), and the air exhaust pipeline (4) is provided with an air exhaust unit (2); the air supply pipeline (3) is communicated with the air exhaust pipeline (4) through a sterilization bypass air pipeline (5); the sterilization bypass air pipeline (5) is communicated with one end of a return air pipeline (6); the other end of the return air pipeline (6) is communicated with the inlet end of the air supply pipeline (3); and the inlet end of the air supply pipeline (3) is further provided with a fresh air bypass air pipeline (7); An air supply airtight valve (18) and an air exhaust airtight valve (19) are respectively arranged in the working room (22); the air supply airtight valve (18) is communicated with the air supply air handling unit (1) through the air supply pipeline (3); the air supply airtight valve (18) controls the air volume entering the working room (22); the air exhaust airtight valve (19) is communicated with the air exhaust unit (2) through the air exhaust pipeline (4); the air exhaust airtight valve (19) controls the air volume exhausted from the working room (22); the inlet end of the air supply airtight valve (18) is provided with an air supply variable air volume valve (20) for controlling the air volume entering the working room (22); and the outlet end of the air exhaust airtight valve (19) is provided with an air exhaust variable air volume valve (21) for controlling the air volume exhausted from the working room (22); The inlet end of the air supply air handling unit (1) is respectively provided with a sixth airtight valve (13) and a first adjusting valve (14) for controlling the air volume entering the air supply air handling unit (1); the outlet end of the air supply air handling unit (1) is respectively provided with a first airtight valve (8) and a fourth adjusting valve (17) for controlling the air volume supplied by the air supply air handling unit (1); the outlet end of the air exhaust pipeline (4) is respectively provided with a third airtight valve (10) and a third adjusting valve (16) for controlling the air volume exhausted by the air exhaust unit (2); the sterilization bypass air pipeline (5) is provided with a second airtight valve (9) for controlling the opening and closing of the pipeline; the return air pipeline (6) is respectively provided with a fourth airtight valve (11) and a second adjusting valve (15) for adjusting the proportion of return air; and the fresh air bypass air pipeline (7) is provided with a fifth airtight valve (12) and a manual adjusting valve for controlling the opening and closing of the pipeline; The first airtight valve (8), the second airtight valve (9), the third airtight valve (10), the fourth airtight valve (11), the fifth airtight valve (12) and the sixth airtight valve (13) are respectively connected with a control system signal; and the control system controls the opening and closing; The first adjusting valve (14), the second adjusting valve (15), the third adjusting valve (16) and the fourth adjusting valve (17) are respectively connected with the control system signal; and the control system controls the opening and closing degree; The control system controls the opening and closing degree of the first adjusting valve (14), the second adjusting valve (15) and the third adjusting valve (16) through the monitoring signals of a received carbon dioxide concentration detector (23) and an online dust particle counter (24) to automatically adjust the indoor air quality. The control system is also connected with the air supply air handling unit (1) and the exhaust air handling unit (2) respectively for controlling air supply and exhaust.

2. A risk assessment based high level pathogen laboratory air loop air conditioning system as defined in claim 1 wherein: The workroom (22) comprises a changing room, a compulsory shower room, a buffer room and an isolation aisle, and a carbon dioxide concentration detector (23) and an online dust particle counter (24) are arranged in the isolation aisle.

3. A control mode of a high-level pathogenic microorganism laboratory circulating air conditioning system based on risk assessment, realized by the high-level pathogenic microorganism laboratory circulating air conditioning system based on risk assessment of any one of claims 1 or 2, characterized in that: When the control mode is a fresh air mode, the air supply air handling unit (1) and the exhaust air handling unit (2) are started, the first closed valve (8), the third closed valve (10) and the sixth closed valve (13) are opened, the second closed valve (9), the fourth closed valve (11) and the fifth closed valve (12) are closed, the first regulating valve (14), the third regulating valve (16) and the fourth regulating valve (17) are adjusted to 100% open state respectively, the second regulating valve (15) is adjusted to 0% closed state, and the air in the workroom (22) is always kept in a fresh air mode; When the control mode is a circulating air mode, the air supply air handling unit (1) and the exhaust air handling unit (2) are started, the first closed valve (8), the third closed valve (10), the fourth closed valve (11) and the fifth closed valve (12) are opened, the second closed valve (9) and the sixth closed valve (13) are closed, the first regulating valve (14) is adjusted to 20% open state, the second regulating valve (15) is adjusted to 80% open state, the third regulating valve (16) is adjusted to 20% open state, the fourth regulating valve (17) is adjusted to 100% open state, and the air in the workroom (22) circulates in a state of 20% fresh air and 80% return air; When the laboratory is normally operated in a circulating air mode, the self-control is based on risk assessment, and when biological safety hidden dangers or risks occur in the laboratory, the laboratory is automatically switched to a fresh air mode, and the workroom (22) can ensure a negative pressure state during the switching process to meet relevant requirements; When the control mode is a disinfection mode, it is divided into three stages of circulation, standing and replacement; When in the circulation stage, the air supply air handling unit (1) is closed, the exhaust air handling unit (2) is started, the operating frequency of the exhaust air handling unit (2) is set to 40 Hz, the parameters are set to a circulation time of 300 minutes, the second closed valve (9) is opened, the first closed valve (8), the third closed valve (10), the fourth closed valve (11), the fifth closed valve (12) and the sixth closed valve (13) are closed, and the first regulating valve (14), the second regulating valve (15), the third regulating valve (16) and the fourth regulating valve (17) are adjusted to 0% closed state, and the disinfection gas in the workroom (22) circulates. In the static stage, the air supply air handling unit (1) is closed, the exhaust air handling unit (2) is started, the operating frequency of the exhaust air handling unit (2) is set to 40 Hz, the parameter is set to the static time of 120 minutes, the second closed valve (9) is opened, the first closed valve (8), the third closed valve (10), the fourth closed valve (11), the fifth closed valve (12) and the sixth closed valve (13) are closed, the first regulating valve (14), the second regulating valve (15), the third regulating valve (16) and the fourth regulating valve (17) are adjusted to the closed state of 0%, and the sterilizing gas in the working room (22) is static. In the replacement stage, the air supply air handling unit (1) is closed, the exhaust air handling unit (2) is started, the operating frequency of the exhaust air handling unit (2) is set to 40 Hz, the parameter is set to the replacement time of 240 minutes, the first closed valve (8), the third closed valve (10), the fourth closed valve (11) and the fifth closed valve (12) are opened, the second closed valve (9) and the sixth closed valve (13) are closed, the first regulating valve (14), the third regulating valve (16) and the fourth regulating valve (17) are adjusted to the open state of 100%, the second regulating valve (15) is adjusted to the closed state of 0%, the sterilizing gas in the working room (22) is exhausted through the exhaust air handling unit (2), and the working room (22) is replaced with fresh air.

Images