A skin care composition with skin soothing and anti-allergic effects and its application

Abstract

This invention discloses a skincare composition with soothing and anti-allergic effects and its application, belonging to the field of cosmetic technology. The skincare composition comprises the following components in parts by weight: 5-15 parts of Clematis VITALBA leaf extract, 2-7 parts of Ginkgo BILOBA leaf extract, 2-7 parts of Pteris MULTIFIDA extract, 10-100 parts of polysorbate-20, and 20-300 parts of solvent. The skincare composition with soothing and anti-allergic effects provided by this invention has excellent anti-allergic effects, fewer side effects, and a wider range of applications. It also requires small dosage, is simple to operate, has controllable components, and is highly safe.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a skin care composition with soothing and anti-allergic effects and its application. Background Technology

[0002] With increasing environmental pollution and life stress, allergic diseases are becoming a growing health problem. Currently available anti-allergy agents are mostly single-ingredient or simply extracted from plants, with limited active ingredients, resulting in limited anti-allergy effects and potential side effects. Therefore, this invention aims to develop a skincare composition with soothing and anti-allergy effects, utilizing the synergistic effect of active ingredients from pure natural plants to enhance anti-allergy efficacy, reduce side effects, and meet the health needs of a broad population. Summary of the Invention

[0003] To address the aforementioned problems, the purpose of this invention is to provide a skincare composition with soothing and anti-allergic effects, and its application, exhibiting excellent anti-allergic, anti-inflammatory, and antipruritic effects.

[0004] Therefore, the present invention adopts the following technical solution:

[0005] This invention provides a skin care composition with soothing and anti-allergic effects, comprising the following components in parts by weight: 5-15 parts of Clematis VITALBA leaf extract, 2-7 parts of Ginkgo BILOBA leaf extract, 2-7 parts of Pteris MULTIFIDA extract, 10-100 parts of polysorbate-20, and 20-300 parts of solvent.

[0006] Preferably, the solvent comprises a polyol and water, wherein the polyol is selected from one or more of glycerol, propylene glycol, butanediol, 1,2-hexanediol, and pentanediol.

[0007] Preferably, the weight ratio of the polyol to water is (1-3):1.

[0008] Preferably, it also contains one or more plant extracts selected from oats, white chrysanthemum and licorice, or a variety of plant co-extracts.

[0009] Furthermore, the plant extract is a mixed extract of oats, white chrysanthemum, and licorice, and the preparation method of the plant extract includes the following steps:

[0010] S1. Mix oats, white chrysanthemum flowers and licorice, grind them into powder, and pass them through a 50-100 mesh sieve to obtain a mixed powder;

[0011] S2, disperse the mixed powder obtained in S1 with a mixed solution of 5-15 times the volume of ethanol and water, stir at 95-100℃ for 3-7h, control the stirring speed at 30-150r / min, filter and sterilize to obtain filtrate;

[0012] S3, concentrate and dry the filtrate obtained in S2 to obtain the final product.

[0013] Preferably, the weight ratio of oats, white chrysanthemum and licorice is (1-2):(1-2):(5-11).

[0014] Preferably, the volume ratio of ethanol to water in S2 is (1-10):(1-10).

[0015] Preferably, the product comprises the following components in parts by weight: 5-15 parts of Clematis VITALBA leaf extract, 2-7 parts of Ginkgo BILOBA leaf extract, 2-7 parts of Pteris MULTIFIDA extract, 5-10 parts of Avenasatativa extract, 5-10 parts of Anthemes SNOBILIS flower extract, 15-50 parts of Glycyrrhiza uralensis extract, 20-50 parts of polysorbate-20, and 50-300 parts of solvent.

[0016] Preferably, it also includes a preservative comprising 1,2-hexanediol and p-hydroxyacetophenone, wherein the weight ratio of 1,2-hexanediol to p-hydroxyacetophenone is (1-3):1.

[0017] The present invention also provides the application of a skin care composition with soothing and anti-allergic effects in cosmetics, wherein the cosmetics include toners, creams, lotions, masks, and sprays.

[0018] The cosmetics include anti-itch products, sensitive skin care products, sunscreen and after-sun repair products, and children's care products, such as anti-itch creams, anti-itch shower gels, anti-itch shampoos, skin itching products, anti-itch floral water, moisturizing lotions, anti-allergy repair creams, sensitive skin repair masks, and allergic dermatitis products.

[0019] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0020] This invention uses a scientifically formulated combination of extracts from clematis vitala leaves, ginkgo biloba leaves, and pteris multifida leaves, which work synergistically to produce a good anti-allergic effect.

[0021] This invention also employs a compound of three ingredients: oats, white chamomile, and licorice, which can further enhance the anti-allergic effect through synergistic action. Oat extracts contain alkaloids with significant anti-allergic and soothing effects, while white chamomile possesses anti-inflammatory and anti-allergic properties. Licorice, on the other hand, can inhibit allergic reactions and enhance skin immunity. By carefully adjusting the proportions of these three ingredients, the anti-allergic effect can be maximized.

[0022] This invention uses oats, white chamomile, and licorice in a suitable ratio to extract active ingredients, and combines them with clematis vitala leaf extract, ginkgo biloba leaf extract, and pteris mutilida extract to achieve excellent anti-inflammatory and antipruritic effects.

[0023] The skin care composition of the present invention, which has the effect of soothing the skin and preventing allergies, has excellent anti-allergic effect, fewer side effects and a wider range of applications. It also requires small dosage, is easy to operate, has controllable ingredients and is highly safe.

[0024] Instruction manual illustrations

[0025] Figure 1 This is a diagram showing the antihistamine effect of the skincare composition in Example 1 of Experimental Example 2 of this invention;

[0026] Figure 2 These are before and after images of the cream containing the skincare composition of Example 1 in Experimental Example 3 of the present invention. Detailed Implementation

[0027] The following specific embodiments further describe the detailed implementation of the technical solution described herein. These embodiments are for the purpose of detailed description of the technical solution and not for limiting the technical solution. Based on the embodiments in this description, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this description. Unless otherwise specified, the reagents, methods, and equipment used in this invention are conventional reagents, methods, and equipment in this technical field, and the reagents and materials used in the following embodiments are all commercially available.

[0028] *Clematis vitalba*, a grape-leaf clematis, belongs to the *Clematis* genus in the Ranunculaceae family. It is a woody vine with bipinnate or trifoliate compound leaves. It blooms on new shoots in late spring, summer, and early autumn, producing upright, spreading flowers up to 5 cm in diameter with 4 or 5-6 white sepals. At least one generation of its parents belongs to the *Clematis* genus: *Clematis vitalba*, *Clematis potaninii*, or *Clematis virginiana*. This type of clematis is best planted shallowly and heavily pruned in winter, maintaining a height of only 20 cm. Its medicinal properties include dispelling wind and dampness, clearing the meridians, and detoxification.

[0029] The leaf extract of Clematis vitalba was purchased from Shaanxi Xiazhou Biotechnology Co., Ltd.

[0030] Ginkgo biloba leaf extract was purchased from Shaanxi Huinengda Biotechnology Co., Ltd.

[0031] Pteris multifida extract was purchased from Shaanxi Lvlai Biotechnology Co., Ltd.

[0032] Oat extract was purchased from Yangling Ciyuan Biotechnology Co., Ltd.

[0033] The extract of white chrysanthemum was purchased from Lanzhou Waterles Biotechnology Co., Ltd.

[0034] The licorice extract was purchased from Shaanxi Chenming Biotechnology Co., Ltd.

[0035] Example 1

[0036] A skincare composition with soothing and anti-allergic effects comprises the following components in parts by weight: 12 parts of Clematis VITALBA leaf extract, 5 parts of Ginkgo BILOBA leaf extract, 5 parts of Pteris MULTIFIDA extract, 25 parts of polysorbate-20, 30 parts of butylene glycol, and 20 parts of water.

[0037] Example 2

[0038] A skincare composition with soothing and anti-allergic effects comprises the following components in parts by weight: 5 parts of Clematis VITALBA leaf extract, 7 parts of Ginkgo BILOBA leaf extract, 5 parts of Pteris MULTIFIDA extract, 18 parts of polysorbate-20, 25 parts of butylene glycol, and 20 parts of water.

[0039] Example 3

[0040] A skincare composition with soothing and anti-allergic effects comprises the following components in parts by weight: 10 parts of Clematis VITALBA leaf extract, 6 parts of Ginkgo BILOBA leaf extract, 4 parts of Pteris MULTIFIDA extract, 20 parts of polysorbate-20, 30 parts of butylene glycol, and 20 parts of water.

[0041] Example 4

[0042] A skincare composition with soothing and anti-allergic effects comprises the following components in parts by weight: 12 parts of Clematis VITALBA leaf extract, 5 parts of Ginkgo BILOBA leaf extract, 5 parts of Pteris MULTIFIDA extract, 5 parts of oat extract, 30 parts of polysorbate-20, 30 parts of butylene glycol, and 25 parts of water.

[0043] Example 5

[0044] A skincare composition with soothing and anti-allergic effects comprises the following components in parts by weight: 10 parts of Clematis VITALBA leaf extract, 6 parts of Ginkgo BILOBA leaf extract, 4 parts of Pteris MULTIFIDA extract, 5 parts of Chamomile scabra flower extract, 30 parts of polysorbate-20, 40 parts of butylene glycol, and 30 parts of water.

[0045] Example 6

[0046] 10 parts of clematis vitala leaf extract, 6 parts of ginkgo biloba leaf extract, 5 parts of pteris multifida extract, 6 parts of licorice extract, 40 parts of polysorbate-20, 30 parts of butylene glycol, and 30 parts of water.

[0047] Example 7

[0048] 15 parts of clematis vitala leaf extract, 6 parts of ginkgo biloba leaf extract, 5 parts of pteris multifida extract, 7 parts of oat extract, 7 parts of white chamomile flower extract, 50 parts of polysorbate-20, 60 parts of butylene glycol, and 30 parts of water.

[0049] Example 8

[0050] 7 parts of clematis vitala leaf extract, 5 parts of ginkgo biloba leaf extract, 5 parts of pteris multifida extract, 10 parts of oat extract, 20 parts of licorice extract, 55 parts of polysorbate-20, 60 parts of butylene glycol, and 50 parts of water.

[0051] Example 9

[0052] 7 parts of clematis vitala leaf extract, 5 parts of ginkgo biloba leaf extract, 5 parts of pteris multifida extract, 5 parts of chamomile extract, 15 parts of licorice extract, 45 parts of polysorbate-20, 60 parts of butylene glycol, and 20 parts of water.

[0053] Example 10

[0054] 5 parts of clematis vitala leaf extract, 5 parts of ginkgo biloba leaf extract, 5 parts of pteris multifida extract, 5 parts of oat extract, 5 parts of chamomile flower extract, 25 parts of licorice root extract, 75 parts of polysorbate-20, 145 parts of butylene glycol, 5 parts of 1,2-hexanediol, and 20 parts of water.

[0055] Example 11

[0056] 5 parts of clematis vitala leaf extract, 5 parts of ginkgo biloba leaf extract, 5 parts of pteris multifida extract, 35 parts of plant co-extracts, 75 parts of polysorbate-20, 145 parts of butylene glycol, 5 parts of 1,2-hexanediol, and 20 parts of water.

[0057] The method for preparing the plant co-extract includes the following steps:

[0058] S1. Mix oats, white chrysanthemum and licorice root in a ratio of 1:1:5, grind them into powder, and pass them through a 50-100 mesh sieve to obtain mixed powder;

[0059] S2, the mixed powder obtained in S1 is dispersed in a mixed solution of 10 times the volume of ethanol and water (v1:v2 = 5:1), stirred at 95℃ for 5 hours, with the stirring speed controlled at 50 r / min, filtered through a 0.1 μm pleated filter, and sterilized at a sterilization temperature of 100-121℃ for 20-30 min to obtain the filtrate;

[0060] S3, concentrate and freeze-dry the filtrate obtained in S2 to obtain the final product.

[0061] Comparative Example 1

[0062] Compared with Example 1, the difference is that it does not contain grape leaf clematis (CLEMATIS VITALBA) leaf extract, but all other aspects are the same.

[0063] Comparative Example 2

[0064] Compared with Example 1, the difference is that it does not contain Ginkgo biloba leaf extract, but all other aspects are the same.

[0065] Comparative Example 3

[0066] Compared with Example 1, the difference is that it does not contain Pteris multifida extract, but all other aspects are the same.

[0067] Preparation method of the skin care composition in the examples and comparative examples: Mix all components evenly to obtain the product.

[0068] Application examples

[0069] The skin care composition, which is a cream containing anti-inflammatory and antipruritic active ingredients, is prepared by adding 10% of the skin care composition of the example or comparative example to the emulsion base and stirring thoroughly until homogeneous.

[0070] The emulsion matrix comprises 0.05% disodium EDTA, 5% glycerol, 2% sodium hyaluronate, 0.2% xanthan gum, 4% caprylic / capric triglyceride, 2% isononyl isononanoate, 2% sorbitan isostearate, 1% glyceryl stearate, 0.5% 1,2-hexanediol, 0.4% p-hydroxyacetophenone, and the balance being water.

[0071] The following specific experiments demonstrate the beneficial effects of the present invention:

[0072] Experimental Example 1: Anti-inflammatory and Antipruritic Activity Test

[0073] The anti-inflammatory and antipruritic activity of the skin care composition of the present invention was evaluated by inhibiting oxazolone-induced ear contact allergic dermatitis in mice and compound 48 / 80-induced pruritus in mice.

[0074] 1. Inhibitory effect on oxazolone-induced contact allergic dermatitis in mice

[0075] Female ICR mice aged 8-10 weeks were randomly divided into a control group and an experimental group (using the skincare compositions of Examples 1-11 and Comparative Examples 1-3, respectively), with 32 animals in each group. Oxazolone was prepared as a 3% solution (olive oil / acetone = 4 / 1). 50 μL of this oxazolone solution was used to treat the shaved abdomen of the ICR mice to induce an allergic reaction. Five days later, 20 μL of a 2% oxazolone-acetone solution was used to treat the back of the left ear of the mice, while the right ear remained untreated. One hour later, 20 μL of physiological saline, or 0.5% aqueous solution of the skincare compositions of Examples 1-11 and Comparative Examples 1-3 (the same below), were applied to the back of the left ear, while the right ear remained untreated. Twenty-four hours later, the animals were euthanized by cervical dislocation, and 8 mm diameter holes were made in both ears. The ears were weighed separately, and the difference was calculated. The inhibition rate of the inflammatory response was calculated by comparing the differences in ear weight among the treatment groups. The test results are shown in Table 1.

[0076] 2. Inhibitory effect on histamine-producing compound 48 / 80-induced pruritus response in mice.

[0077] ICR mice were randomly divided into a model group and an experimental group (referred to as Examples 1-11 and Comparative Examples 1-3, respectively), with 32 animals in each group. The mice were shaved on their backs the day before the experiment, with the shaved area approximately 2×2 cm. 2 On the day of the experiment, compound 48 / 80 (0.1% saline solution) was evenly applied to the backs of ICR mice to induce an itching response. The model group and experimental group were then evenly applied with saline solution, solutions of 0.5% skin care compositions from Examples 1-11 and Comparative Examples 1-3, respectively. Mouse behavior was immediately observed, and the number of scratches was recorded within 30 minutes. The inhibition rate of the itching response was calculated by comparing the difference in the number of scratches between the two groups. The test results are shown in Table 1.

[0078] Table 1. Results of anti-inflammatory and antipruritic tests

[0079]

[0080]

[0081] As shown in Table 1, the skin care compositions of Examples 1-11 showed an inhibition rate of 70.7%-96.2% against contact allergic dermatitis and an inhibition rate of 68.5%-88.4% against compound 48 / 80-induced pruritus in mice, which were significantly higher than those of Comparative Examples 1-3. This indicates that the skin care compositions provided by the present invention have good anti-inflammatory and antipruritic effects. Among them, Examples 4-6, compared to Examples 1-3, added one of the following: oat extract, white chrysanthemum flower extract, and licorice root extract, resulting in a certain degree of improvement in both inflammation inhibition rate and pruritus inhibition rate. Examples 7-9, compared to Examples 1-3, added two of the following: oat extract, white chrysanthemum flower extract, and licorice root extract, resulting in a certain degree of improvement in both inflammation inhibition rate and pruritus inhibition rate, but not a particularly significant improvement compared to Examples 4-6. Example 10, compared to Examples 1-3, added three components: oat extract, white chrysanthemum flower extract, and licorice root extract, resulting in a significant increase in both inflammation inhibition rate and pruritus inhibition rate, indicating that oat extract, white chrysanthemum flower extract, and licorice root extract can work synergistically to enhance anti-inflammatory and antipruritic effects. Example 11, compared to Example 10, differs in that it was prepared by co-extraction of oat, white chrysanthemum, and licorice extracts, resulting in a higher inflammation inhibition rate and pruritus inhibition rate than Example 10, indicating that the skin care composition of Example 11 has better anti-inflammatory and antipruritic effects.

[0082] Experimental Example 2: In vitro antihistamine activity test

[0083] The skin prick test was used to test the antihistamine effect of the skin care composition of the present invention. Test group: 10 mg / mL histamine phosphate solution (containing 50% glycerin) + 0.5% concentration of the skin care composition of Example 1; Positive control group: 10 mg / mL histamine phosphate solution (containing 50% glycerin). The degree of redness and swelling of the erythema was observed visually. Figure 1 As shown.

[0084] Figure 1 A is the positive control group. Figure 1 Group B is the test group. It can be seen that the test group, with the addition of 0.5% of the skincare composition, showed a significant reduction in erythema and edema. This indicates that the skincare composition provided in this embodiment of the invention can improve and reduce the amount of redness and erythema caused by histamine, and has good antihistamine activity.

[0085] Experiment Example 3: Human Efficacy Experiment

[0086] One hundred and eighty participants with skin allergies, aged 18-60 years, were randomly divided into six groups (30 participants in each group). 10% by weight of the skincare compositions from Examples 1, 10, and 11, as well as Comparative Examples 1-3, were added to a standard lotion base to prepare a test cream. The cream was applied twice daily, morning and evening, after cleaning the affected skin area before application, and used continuously for seven days.

[0087] Judgment criteria:

[0088] (1) Significant effect: Allergic reactions such as skin redness, itching, and edema disappear.

[0089] (2) Effective: Reduces allergic reactions such as skin redness, itching, and edema.

[0090] (3) Ineffective: No significant change in allergic reactions such as skin redness, itching, and edema.

[0091] (4) Worsening: Allergic symptoms such as skin redness, itching, and edema worsen.

[0092] Table 2 Test Results

[0093]

[0094]

[0095] As shown in Table 2, the skincare composition of the present invention can effectively improve allergic reactions such as skin redness, itching, and edema, and has anti-allergic, soothing, and anti-inflammatory effects. The skincare composition provided by the present invention is gentle and non-irritating to the skin.

[0096] Figure 2 A and Figure 2 B shows the effect before and after application of the cream from Example 1, illustrating that the skincare composition provided in Example 1 can effectively reduce erythema.

[0097] In summary, the skin care composition provided by this invention, which has soothing and anti-allergic effects, has rapid anti-inflammatory, antipruritic, antihistamine, anti-allergic, anti-irritant, and anti-erythema effects.

[0098] Although embodiments of the present description have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present description, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A skincare composition with soothing and anti-allergic effects, characterized in that, Composed of the following components in parts by weight: 5-15 parts of Clematis vitala leaf extract, 2-7 parts of Ginkgo biloba leaf extract, 2-7 parts of Pteris multifida extract, 5-35 parts of a plant co-extract of oats, white chamomile, and licorice, and polysorbate-20. 10-100 parts of the extract and 20-300 parts of solvent; the solvent is a polyol and water, wherein the polyol is butanediol or a combination of butanediol and 1,2-hexanediol; the preparation method of the plant co-extract includes the following steps: S1, mixing oats, white chrysanthemum and licorice, grinding them into powder, and passing them through a 50-100 mesh sieve to obtain a mixed powder; S2, dispersing the mixed powder obtained in S1 with a mixed solution of 5-15 times the volume of ethanol and water, stirring at 95-100℃ for 3-7 hours, controlling the stirring speed at 30-150 r / min, filtering and sterilizing to obtain a filtrate; S3, concentrating and drying the filtrate obtained in S2 to obtain the final product; the weight ratio of oats, white chrysanthemum and licorice is (1-2):(1-2):(5-11).

2. The skincare composition with soothing and anti-allergic effects according to claim 1, characterized in that, The weight ratio of the polyol to water is (1-3):

1.

3. The skincare composition with soothing and anti-allergic effects according to claim 1, characterized in that, The volume ratio of ethanol to water in S2 is (1-10):(1-10).

4. The skincare composition with soothing and anti-allergic effects according to claim 1, characterized in that, It also contains a preservative comprising 1,2-hexanediol and p-hydroxyacetophenone in a weight ratio of (1-3):1.

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