A rumen continuous drug delivery system

Abstract

The present invention provides a rumen continuous drug delivery system, comprising: a slow-release bin body, having a prismatic outer wall and a cylindrical inner wall, the first end of the slow-release bin body being open, and a spring and a plunger being arranged therein; an end cover, being combined with the first end of the slow-release bin body, and having an opening formed therein; a wing, being arranged at the second end of the slow-release bin body, extending along the radial direction of the slow-release bin body, the wing being able to bend and fit with the outer wall of the slow-release bin body, and a plurality of "fish scale grooves" being arranged on both sides of the wing, and the "fish scale grooves" passing through the thickness of the wing and being arranged in a staggered manner at the sites on both sides of the wing. The rumen slow-release bin provided by the present invention increases the overall fluid dynamics performance of the slow-release bin, avoids entanglement of grass and materials, and enhances effectiveness and practicality.

Description

Technical Field

[0001] The invention relates to the field of animal husbandry and veterinary medicine, and in particular to a rumen continuous drug delivery system. Background Art

[0002] With the progress of modern agriculture, intensive ranches have developed rapidly. Intensive ranches focus on scientific and technological investment and technological innovation, and focus on improving breeding efficiency and quality, making dairy cattle breeding more scientific and efficient.

[0003] In the production application of dairy cows, in order to ensure their health and production efficiency, long-term and continuous drug administration strategies are often implemented for key drugs such as anthelmintics, antibiotics, vitamins, plant extracts, trace elements, etc. Especially in intensive pastures, where the number of animals is large and management is complex, long-acting sustained-release preparations can continuously release drugs for a predetermined long period of time, which can simplify the drug administration process, improve management efficiency, and ensure the health and production performance of animals. This means that animals in intensive pastures do not need to be frequently administered, reducing the number of drug administrations and labor costs, making the management of intensive pastures more convenient and efficient, thereby improving the economic benefits of intensive pastures. For grazing animals, there is also a long-term and continuous demand for drug use.

[0004] Sustained-release preparations refer to preparations that can continuously release drugs for a long time after administration to achieve long-term effects. They can release drugs in a certain part of the animal's body and effectively regulate the release rate of the drugs, maintain a constant blood drug concentration, reduce the number of dosing times, avoid uneven drug intake, and thus reduce or eliminate significant "peak and valley" fluctuations in blood drug concentration, ensuring that the drug can steadily exert its therapeutic effect over a long period of time. However, the existing rumen slow-release bins may cause esophageal obstruction or damage during feeding. In addition, due to insufficient strength of the main body and wings of the slow-release bin, some parts may be damaged, and the slow-release bins are prone to cause grass entanglement in the rumen. Summary of the invention

[0005] In order to overcome the shortcomings of the prior art, the present invention provides a rumen continuous drug delivery system, comprising: a sustained-release bin body, having a prismatic outer wall and a cylindrical inner wall, the first end of the sustained-release bin body being open, and a spring and a plunger being arranged therein; an end cover, combined with the first end of the sustained-release bin body, the end cover forming an opening; a wing, arranged at the second end of the sustained-release bin body, extending along the radial direction of the sustained-release bin body, the wing being able to bend and fit with the outer wall of the sustained-release bin body, a plurality of "fish scale grooves" being arranged on both sides of the wing, and the "fish scale grooves" passing through the thickness of the wing and being arranged in a staggered manner at the sites on both sides of the wing.

[0006] Furthermore, a groove is arranged on the outer wall of the slow-release bin body, and the groove is arranged to penetrate along the axial direction of the slow-release bin body.

[0007] Further, the outer surface of the slow-release bin body close to the second end is formed into an arc shape, a boss is provided at the end of the arc surface, and the wing is connected to the boss.

[0008] Further, the thickness of the boss along the axial direction of the slow-release bin body is greater than the thickness of the wing, and the width of the boss along the radial direction of the slow-release bin body is greater than the width of the wing.

[0009] Further, the slow-release bin includes a pair of wings, and the pair of wings extend outwardly in opposite directions of the boss, so that the rumen slow-release bin is formed into a T-shape.

[0010] Furthermore, the "fish scale groove" includes a first wall, a second wall and a third wall, wherein the first wall is parallel to the length direction of the wing, the second wall is closer to the boss relative to the third wall, the second wall is perpendicular to the first wall, and the angle between the third wall and the first wall is an obtuse angle.

[0011] Furthermore, the first wall has a dimension L1 along the wing length direction, and the second wall has a dimension L2 along the wing width direction, wherein L1 <L2。

[0012] Furthermore, the width of the wing gradually increases from the boss to the end of the wing.

[0013] Furthermore, a reinforcing rib is provided on the upper surface of the wing, and the reinforcing rib is arranged to extend from the boss along the length direction of the wing to approximately the center of the wing.

[0014] Furthermore, the distal end of the wing is bent toward the slow-release chamber and forms a thickened blunt round shape.

[0015] The present invention can achieve at least one of the following beneficial effects:

[0016] The rumen slow-release bin provided by the present invention can avoid the phenomenon of esophageal obstruction or damage that may occur during feeding.

[0017] The rumen slow-release bin provided by the present invention reinforces multiple parts of the slow-release bin body and wings to prevent damage caused by insufficient strength of some parts of the slow-release bin body and wings, thereby improving safety and stability.

[0018] The rumen slow-release bin provided by the present invention increases the overall fluid dynamics performance of the slow-release bin, avoids entanglement of grass and feed, and thus enhances its effectiveness and practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0020] Figure 1is a schematic diagram of the rumen sustained drug delivery system of the present invention;

[0021] Figure 2 It is a schematic diagram of the piston structure of the rumen continuous drug delivery system of the present invention;

[0022] Figure 3 is a partial cross-sectional view of the rumen continuous drug delivery system of the present invention;

[0023] Figure 4 yes Figure 3 A magnified view of part B;

[0024] Figure 5 Shows Figure 3 The CC-axis structural diagram shows the bone structure;

[0025] Figure 6 : is a schematic diagram of the top view of the rumen continuous drug delivery system of the present invention, and the dotted line portion schematically shows the thread-like structure of the fish scale groove;

[0026] Figure 7 yes Figure 6 A magnified view of part A;

[0027] Figure 8 This is the result diagram of simulation under forage parameters;

[0028] Description of reference numerals:

[0029] 10 rumen continuous drug delivery system; 100 slow-release chamber body; 101 first end; 102 second end; 110 groove; 120 bone structure; 130 piston; 131 hole; 140 spring; 200 end cover; 300 wing; 310 fish scale groove; 311 first wall surface, 312 second wall surface; 313 third wall surface; 320 reinforcing rib; 400 boss; DETAILED DESCRIPTION

[0030] The following will clearly and completely describe the concept, specific structure and technical effects of the present invention in combination with the embodiments and drawings, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, other embodiments obtained by technicians in this field without creative work are all within the scope of protection of the present invention. In addition, all the connection / connection relationships involved in the invention do not simply refer to the direct connection of components, but refer to the fact that a better connection structure can be formed by adding or reducing connection accessories according to the specific implementation situation. The various technical features in the present invention can be combined interchangeably without conflicting with each other.

[0031] Reference Figures 1 to 7The rumen sustained drug delivery system 10 provided by the present invention comprises a sustained-release chamber body 100, an end cover 200 and a wing 300. The outer wall of the sustained-release chamber body 100 is prismatic and the inner wall is cylindrical. The sustained-release chamber body 100 comprises a first end 101 and a second end 102, wherein the first end 101 is open and the second end 102 is closed, and a spring 140 and a piston 130 are arranged in the sustained-release chamber body 100; the end cover 200 is combined with the open first end of the sustained-release chamber body 100, and the end cover 200 is formed with an opening. The wing 300 is arranged at the second end of the sustained-release chamber body 100 and extends along the radial direction of the sustained-release chamber body 100. The wing 300 can be bent and fit with the outer side wall of the sustained-release chamber body 100. A plurality of "fish scale grooves" 310 are arranged on both sides of the wing, and the "fish scale grooves" 310 are arranged through the thickness of the wing 300 and the positions on both sides of the wing 300 are arranged in a staggered manner. Here, the thickness direction of the wing 300 is along the axial direction of the slow-release bin body 100. The width direction of the wing 300 is along the radial direction of the slow-release bin body 100, and is perpendicular to the long side of the wing 300. The "fish scale groove" means that the projection of the groove in the front view is in the shape of fish scales, such as Figure 3 and Figure 4 The fish scale grooves on both sides (in the width direction) of the wing 300 are arranged in a staggered manner to form a thread-like structure, such as Figure 6 and Figure 7 The slow-release bin body 100, the end cover 200 and the wing 300 are all made of polypropylene, and the spring is a steel compression spring.

[0032] In one embodiment, when in use, the compression spring, piston 130, and appropriate amount of tablets are sequentially placed from the bottom of the slow-release chamber body 100, and the end cap 200 is screwed. After the rumen continuous drug delivery system 10 enters the rumen, the steel compression spring can continuously push the solid tablets so that the release surface of the tablets can maintain contact with the inner surface of the end cap and the rumen fluid until all tablets are released. The fish scale grooves 310 on both sides of the wing 300 are arranged in a staggered manner to form a thread-like structure, which, along with the rhythmic peristalsis of the rumen, causes the grass wrapped around the wing to detach from the device. This prevents the grass from wrapping around the rumen slow-release chamber, reducing the impact of the rumen slow-release chamber on the original physiological function of the rumen.

[0033] Specifically, the slow-release bin body 100 includes a first end and a second end. The outer surface of the slow-release bin body 100 near the second end is formed into an arc shape, and a boss 400 is provided at the end of the arc surface. The boss 400 and the slow-release bin body 100 can be integrally formed or fixedly connected. The wing 300 and the boss 400 are preferably fixedly connected. The thickness of the boss 400 along the axial direction of the slow-release bin body 100 is greater than the thickness of the wing 300, and the width of the boss 400 along the radial direction of the slow-release bin body 100 is greater than the width of the wing 300. The boss 400 is provided so that the connection between the slow-release bin body 100 and the wing 300 is reinforced. The provision of the arc-shaped platform structure of the slow-release bin body 100 better protects the stability of the bending area when the wing 300 is bent, strengthens the connection between the wing 300 and the slow-release bin body 100, and reduces the possibility of the wing 300 and the slow-release bin body 100 being broken and separated. The top of the connection between the slow-release chamber body 100 and the wing 300 is thickened to enhance the stability of the connection structure.

[0034] The slow-release chamber body 100 is hollow, and the interior of the slow-release chamber is a hollow cylinder. A sheet-like bone structure 120 corresponding to the external shape is provided near the connection end with the wing 300, i.e., the second end. Figure 5 A platform is formed inside the slow-release bin, which increases the stability of the slow-release bin body 100 itself and the spring.

[0035] In a specific embodiment, the diameter of the inner cylinder of the sustained-release bin body 100 is 30 mm, and six bone structures 120 are evenly distributed inside the sustained-release bin body 100. The appearance of the sustained-release bin body 100 is an equilateral hexagonal column with a side length of 20 mm. Each edge of the hexagonal column is equal in thickness, which is a thickened structure of the sustained-release bin body wall, and the thickness of the barrel wall is between 2.5 mm and 5 mm. The wall thickness parameter design is further thickened on the basis of existing products, and is determined according to the size of the dosing device used in actual production and the physiology of the cow's esophagus. The design has good stability and load-bearing capacity, provides strength for the bin body to prevent it from being damaged in the rumen, causing poisoning caused by overdose of drugs, and avoiding situations such as spring damage to tissues. On the basis of reinforcing the bin body with a hexagonal structure, the volume of the reinforced sustained-release bin is minimized. Each edge is designed as a smooth blunt round structure to avoid damaging the esophagus during dosing and damaging the rumen wall during rumen retention. The improved sustained-release chamber 10 has a stronger fluid dynamics characteristic, which reduces the possibility of swallowing blockage during medication administration.

[0036] In addition, a groove 110 is provided on the outer wall of the slow-release bin body 100, and the groove 110 is provided along the axial direction and is provided on the outer surface of the slow-release bin body 100. Providing a groove on the outer wall of the slow-release bin body 100 can prevent possible esophageal obstruction or damage during feeding, and the slow-release bin from being regurgitated or entering other stomachs. Preferably, at least two grooves 110 may be provided. In a specific embodiment, six grooves 110 are evenly distributed on the outer wall of the slow-release bin body 100.

[0037] In a specific embodiment, the sustained-release chamber body 100 is formed as an equilateral hexagonal cylinder, and each edge of the equilateral hexagonal cylinder is provided with a semicircular groove that runs through the entire cylinder. The semicircular R=2.5mm is designed to ensure that the maximum groove thickness of the cylinder wall is at least 2.5mm. This design will not completely fit the esophagus when esophageal blockage occurs. In addition, an overhead space is formed between the esophageal wall, the side of the cylinder and the two adjacent edges of the side, which reserves space, reduces the severity of the blockage, effectively prolongs the preparation time for dealing with emergencies, and increases the safety of drug administration. The parameter design of the circular groove is the maximum size designed within the wall thickness range, which prevents it from fitting with the esophagus to the greatest extent while ensuring the stability of the main body of the rumen continuous drug delivery system 10.

[0038] Preferably, the rumen sustained drug delivery system 10 includes a pair of wings 300, which extend outward in opposite directions from the boss 400, so that the rumen sustained drug delivery system 10 is formed into a T-shape. The pair of wings 300 are both made of elastic material, so that the wings 300 can be folded close to the outer wall of the slow-release chamber body 100, and can be restored to the original shape after a short period of deformation, that is, the rumen sustained drug delivery system 10 is restored to a T-shape.

[0039] The sides of the outer part of the central area of ​​both wings are designed with "fish scale-like grooves", namely fish scale grooves 310. The two side groove sites of the same wing are arranged in a staggered manner to form a spiral local structure, which strengthens the hydrodynamic characteristics of the wing and can promote the grass wrapped around the wing to move further away from the connection between the wing and the main body along the groove, thereby preventing the grass from wrapping around the rumen slow-release chamber, greatly reducing the impact of the rumen slow-release chamber on the original physiological function of the rumen. The narrowness of the wing 300 near the connection is to maintain the bendable characteristics of the wing when feeding; the gradual widening is part of the anti-winding design and a design to increase the overall stability of the wing; the blunt end is to prevent damage to the rumen wall.

[0040] Specifically, in Figure 7In the embodiment, the "fish scale groove" 310 includes a first wall 311, a second wall 312 and a third wall 313, wherein the first wall 311 is parallel to the length direction of the wing 300, the second wall 312 is closer to the boss 400 than the third wall 313, the second wall 312 is perpendicular to the first wall 311, and the angle between the third wall 313 and the first wall 311 is an obtuse angle. The dimension L1 of the first wall 311 along the length direction of the wing, and the dimension L2 of the second wall 312 along the width direction of the wing, wherein L1>L2, are more conducive to the separation of grass. In a specific preferred embodiment, for example, L1=1.1 mm, L2=0.4 mm, the parameters of each groove are consistent, and the spacing distance of the grooves on the same side is consistent. The width of the wing 300 gradually increases from the boss 400 to the end of the wing 300. The fluid performance at the connection between the capsule and the wing will not cause entanglement. The principle of shedding is that the grooves on both sides of the wing are arranged in a staggered manner to form a thread-like structure, which, accompanied by the rhythmic peristalsis of the rumen, causes the forage entangled on the wing to detach from the device.

[0041] In a specific preferred embodiment, the design is a local embodiment of a sawtooth thread, with a working edge β = 0°, a non-working edge β = 63.44°, p = 3 mm, and a tooth bottom depth of 0.4 mm. Figure 7 As shown (shown in the figure). The grooves on both sides are staggered with a pitch of 3mm. The serrated thread is a type of thread that provides unidirectional power, and the design is the same as the principle of the serrated thread. Under the force of the peristalsis of the rumen body, when the grass is wrapped around the two side wings and embedded in the grooves, the working edge prevents the grass from moving toward the connection part, thereby causing it to move outward along the non-working edge. The grooves on both sides of the same wing are staggered, which is a partial manifestation of the thread structure, so that the grass maintains continuity in the force during the shedding process. In addition, the wing width gradually widens from the connection part to the outside. The structure of the grass becomes loose in the process of moving outward, and eventually it detaches from the sustained-release capsule, which serves the purpose of preventing winding.

[0042] In addition, there is a circular ridged protrusion in the center of each wing 300, which serves as the central skeleton structure of the wing, plays a role in reinforcement and fracture prevention, and can effectively maintain the initial shape of the wing, preventing the elasticity of the wing from weakening due to long-term compression, making it difficult to maintain the "T" shape structure and affecting the rumen retention function. The overall length of the wing is increased, and the improved width design together increases the safety of the capsule retention in the rumen, adapting to the increasing height of dairy cows year by year.

[0043] Specifically, the upper surface of the wing 300 (i.e., the surface away from the slow-release bin body) is provided with a reinforcing rib 320, which is arranged to extend from the boss 400 along the length direction of the wing 300 to approximately the center of the wing 300. The connection between the slow-release bin body 100 and the wing 300 is reinforced, and the arc-shaped platform structure better protects the stability of the bending area when the wing is bent, strengthens the connection between the wing 300 and the slow-release bin body 100, and reduces the frequency of the wing and the body breaking and separating. The top of the connection between the slow-release bin body and the wing is thickened to strengthen the stability of the connection structure.

[0044] like Figure 1 As shown, the wing 300 forms a gradually widening streamlined structure from the connection with the boss to its distal end along the length direction, and an arc-shaped blunt round structure bent toward the slow-release chamber body 100 is formed at the end of the wing 300. The gradually widening design makes the rumen continuous drug delivery system 10 easier to insert, and the blunt round structure can prevent damage. The streamlined edge structure in the central area of ​​the two wings enhances the fluid dynamics of the rumen continuous drug delivery system 10, so that the grass cannot be entangled in the connection between the wing and the body, so that the grass can be separated from the connection between the wing and the body along the curved edge during the operation of the rumen. The overall thickness of the wing is enhanced, and the part close to the connection with the body is thickened to maintain the stability and firmness of the wing. The end part of the wing is thickened to enhance the safety of the wing when it is retained in the rumen, and the blunt round design of the end can effectively avoid rumen damage. The original thickness is maintained in the bending area in the middle, retaining the flexibility of the wing, which can be well matched with the dosing device and smoothly pass through the esophagus into the rumen.

[0045] In addition, the bottom outer wall of the sustained-release bin body 100 may be designed with a threaded structure so that it can be matched and combined with the threaded structure on the inner side of the end cap 200. In this design, the bottom cover can maintain a hexagonal structure or a circular structure. With the threaded design, the assembly method of the medicine is increased, which makes it convenient for veterinarians to adjust the type and dosage of medicine according to the physical condition and illness of the cattle, providing the possibility for precise treatment. In addition, the sustained-release bin body 100 and the end cap 200 can be other connection structures, as long as the sustained-release bin body 100 and the end cap 200 are detachably connected.

[0046] A piston 130 and a spring 140 are also provided inside the sustained-release chamber body 100. The piston 130 is provided with a hole 131. In a preferred embodiment, three holes 131 are evenly distributed on the piston 130. One end of the piston abuts against the spring, and the other end contacts the tablet, so that the tablet can abut against the end cover 200 under the pressure of the spring 140 and release the drug through the opening (not shown) of the end cover 200.

[0047] The rumen continuous drug delivery system 10 is used as follows: bend the wings downward along the slow-release chamber body 100 to fit the outer wall of the slow-release chamber body 100, put it into the drug delivery device, and feed it orally into the esophagus through the drug delivery device. The rumen continuous drug delivery system 10 will move into the rumen through the esophagus, and the esophagus can hold the wings 300 in a superimposed position until the rumen continuous drug delivery system 10 reaches the rumen. The improved side wall of the rumen continuous drug delivery system 10 reduces the possibility of drug swallowing obstruction, and reserves space when esophageal obstruction occurs, effectively extending the preparation time for handling emergencies.

[0048] Subsequently, the wing 300 will bounce outward to the extended position and restore the T-shape. The rumen continuous drug delivery system 10 is subjected to continuous and strong mechanical pressure from undigested food in the rumen and rumen movement during normal eating, rumination and digestion. In this extended position, the wing basically presents a straight outer surface, which ensures that the rumen continuous drug delivery system 10 will not enter the reticulum, nor will it be taken out of the rumen due to rumination. The improved rumen continuous drug delivery system 10 of the present invention has a strong fluid dynamics characteristic, and the improved wings have enhanced rigidity, safety, and fluid dynamics properties, prevent the wings from breaking, folding, and damage, and increase the safety and stability of drug delivery.

[0049] The opening on the surface of the end cap 200 is a drug release port. After oral administration, the drug can remain in the rumen for a long time, reducing the number of medications and reducing the stress of dairy cows in the production process. The rumen slow-release bin of the system can be used to deliver various solid tablet drugs, and the type and dosage of the drug can be adjusted before use according to the condition of the cow. The rumen continuous drug delivery system is simple to produce and easy to transport, which has the effect of improving the economic benefits of the ranch. The improved wings enhance the fluid dynamics properties, effectively avoid the entanglement of other foreign objects such as hay, greatly reduce the impact on the original physiological function of the rumen, and increase the effectiveness and practicality of the slow-release bin.

[0050] Structural simulation verification: see Figure 8

[0051] Model design: The rumen is partially set as a sphere with a diameter of 200 mm, and the capsule is located in the center of the sphere. The forage is set to be 1 mm in diameter and 80 mm in length. The texture of the forage is soft (Young's modulus 2e5 pa), and the initial speed is randomly distributed at 0.5-1 m / s.

[0052] Through simulation, the length, diameter, moving speed and quantity of the grass were changed, and no grass fiber was found to be entangled with the capsule during movement. This shows that the structure can effectively prevent the problem of grass entanglement.

[0053] The above is a specific description of the preferred implementation of the present invention, but the invention is not limited to the embodiments. Those skilled in the art can make various equivalent modifications or substitutions without violating the spirit of the present invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A rumen continuous drug delivery system, characterized in that: include: The slow-release bin body has a prismatic outer wall and a cylindrical inner wall, the first end of the slow-release bin body is open, and a spring and a plunger are arranged inside the slow-release bin body; An end cap is coupled to the first end of the slow-release bin body, and the end cap is formed with an opening; A wing is arranged at the second end of the slow-release bin body and extends along the radial direction of the slow-release bin body. The wing can be bent and fit against the outer wall of the slow-release bin body. A plurality of "fish scale grooves" are arranged on both sides of the wing. The "fish scale grooves" penetrate the thickness of the wing and are arranged in a staggered manner at the sites on both sides of the wing to form a threaded structure. The outer surface of the slow-release bin body close to the second end is formed into an arc shape, and a boss is arranged at the end of the arc surface. The wing is connected to the boss, and the width of the wing gradually increases from the boss to the end of the wing.

2. The rumen continuous drug delivery system according to claim 1, characterized in that: A groove is arranged on the outer wall of the slow-release bin body, and the groove is arranged to penetrate along the axial direction of the slow-release bin body.

3. The rumen sustained drug delivery system according to claim 1, characterized in that: The thickness of the boss along the axial direction of the slow-release bin body is greater than the thickness of the wing, and the width of the boss along the radial direction of the slow-release bin body is greater than the width of the wing.

4. The rumen continuous drug delivery system according to claim 1, characterized in that: The slow-release bin includes a pair of wings, which extend outwardly in opposite directions of the bosses, so that the rumen slow-release bin is formed into a T-shape.

5. The rumen sustained drug delivery system according to claim 4, characterized in that: The "fish scale groove" includes a first wall, a second wall and a third wall, wherein the first wall is parallel to the length direction of the wing, the second wall is closer to the boss than the third wall, the second wall is perpendicular to the first wall, and the angle between the third wall and the first wall is an obtuse angle.

6. The rumen sustained drug delivery system according to claim 5, characterized in that: The first wall has a dimension L1 along the wing length direction, and the second wall has a dimension L2 along the wing width direction, wherein L1 <L2。 7. The rumen sustained drug delivery system according to claim 1, characterized in that: A reinforcing rib is disposed on the upper surface of the wing, and the reinforcing rib is arranged to extend from the boss along the length direction of the wing to the center of the wing.

8. The rumen sustained drug delivery system according to claim 7, characterized in that: The distal end of the wing is bent toward the slow-release chamber and has a blunt round shape.

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