Acne-removing scrub shower gel and preparation method thereof

Abstract

The invention discloses an acne-removing scrub shower gel, which belongs to the technical field of skin care products. The acne-removing scrub shower gel provided by the invention can achieve good acne-removing and cleaning effects by selecting suitable components and the mass parts of the components, and the components work together. In addition, the shower gel has good stability and mildness on the basis of having a scrub effect.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care products, and in particular relates to an acne-removing scrub shower gel and a preparation method thereof. Background Art

[0002] Shower gel has become one of the most widely used products in the skin care industry. With the improvement of people's living standards, people's requirements for shower gel are getting higher and higher, such as the user experience and the ability to cleanse the skin. At the same time, some users will also pay attention to whether the shower gel has an acne-removing effect. Summary of the Invention

[0003] The purpose of the present invention is to overcome the deficiencies of the above-mentioned prior art and provide an acne-removing scrub shower gel with excellent cleaning ability, acne-removing effect, excellent stability, low irritation, and excellent user experience, and a preparation method thereof.

[0004] To achieve the above objectives, in a first aspect of the present invention, the present invention provides an acne-removing scrub shower gel, comprising the following components in parts by mass: 0.05-4 parts of scrub particles, 0.2-0.7 parts of acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer, 1-6 parts of suspending agent, 0.01-5 parts of supramolecular capryloyl glycine, 0.01-5 parts of supramolecular salicylic acid, 0.001-1 parts of dihydroxypropyl arginine hydrochloride, 0.001-1 parts of glycerol glucoside, 0.001-15 parts of moisturizing agent, 10-30 parts of surfactant, 0.01-0.1 parts of chelating agent, 0.2-1 parts of preservative, and 20-85 parts of deionized water;

[0005] The abrasive particles include at least one of mannan and sodium polyacrylate;

[0006] The suspending agents include microcrystalline cellulose and cellulose gum.

[0007] The acne-removing scrub shower gel provided by the present invention can achieve good acne-removing and cleaning effects by selecting appropriate components and the mass fractions of the components, and the components work together. In addition, the shower gel has good stability and mildness on the basis of having a scrub effect.

[0008] Specifically, in the first aspect, the shower gel provided by the present invention selects mannan and / or sodium polyacrylate particles as scrub particles, which have a round shape, a smooth surface, and a soft touch, and will not cause irritation or discomfort to the skin, making the scrubbing process more comfortable and gentle. The mannan or sodium polyacrylate particles have a certain elasticity and can slide gently on the skin surface. They are not easy to denature or break, and can effectively maintain the integrity and stability of the particles, effectively remove aged keratin on the skin surface, and will not cause damage to the skin. The present invention further introduces an acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and a suspending agent. The combination of the two can effectively stabilize and suspend the abrasive particles and maintain the stability of the system. Since mannan or sodium polyacrylate has the characteristic of swelling upon water absorption, it becomes heavier after absorbing water. Under the joint action of the acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and the suspending agent, the mannan or sodium polyacrylate particles after absorbing water can be stably suspended, and the gaps between the mannan or sodium polyacrylate particles can be effectively filled to prevent particle sedimentation or stratification. Specifically, the acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer can form an effective space-filling effect after the mannan or sodium polyacrylate swells, and the suspending agent can have a thickening effect through hydrogen bonding. After preparation, it can be uniformly dispersed in the liquid to form a highly thixotropic 3D gel structure carrier. Its unique network structure can stably suspend solid matter.

[0009] Secondly, the supramolecular capryloyl glycine and supramolecular salicylic acid introduced in the present invention both have antibacterial, anti-inflammatory and exfoliating effects, can effectively clean pores, reduce acne formation, and improve acne problems, and the introduced supramolecular capryloyl glycine and supramolecular salicylic acid both have the advantages of higher bioavailability, and are less irritating and more water-soluble than substances with non-supramolecular structures; the simultaneous addition of the two can work synergistically, thereby achieving effective acne removal, accelerating the disappearance of acne, improving skin texture, and making the skin more refreshed and smooth; at the same time, the present invention further selects dihydroxypropyl arginine hydrochloride and glycerol glucoside to cooperate with supramolecular capryloyl glycine and supramolecular salicylic acid, which can make the product have soothing and calming effects while removing acne. Among them, glyceryl glucoside is a type of glycoside compound formed by the connection of glycerol molecules and glucose molecules through glycosidic bonds. It can promote the synthesis of AQP3 water channel protein, comprehensively replenish and lock moisture for skin cells, significantly reduce the release of inflammatory factors IL-1α and IL-1β, inhibit the degranulation reaction of mast cells, improve skin inflammation, relieve skin redness and allergies, etc.; Dihydroxypropyl arginine hydrochloride can balance the skin flora, effectively condition the skin, prevent abnormal keratinization, improve multiple peeling of the stratum corneum, and reduce the risk of acne. After washing with water, it can still be firmly adsorbed on the skin surface, so that the skin continues to maintain a hydrated feeling. It can also effectively resist oxidation and relieve skin redness and allergies.

[0010] In one embodiment, the acne-removing scrub shower gel comprises the following components in parts by mass: 0.1-2 parts of scrub particles, 0.3-0.5 parts of acrylic acid (esters) / C10-30 alkyl acrylate cross-polymer, 2-4 parts of suspending agent, 0.1-3 parts of supramolecular capryloyl glycine, 0.1-3 parts of supramolecular salicylic acid, 0.05-0.5 parts of dihydroxypropyl arginine hydrochloride, 0.05-0.5 parts of glycerol glucoside, 2-10 parts of moisturizer, 12-26 parts of surfactant, 0.01-0.1 parts of chelating agent, 0.2-1 parts of preservative, and 40-80 parts of deionized water.

[0011] The present invention has found that the mass parts of the components in the acne-removing scrub shower gel will have a significant impact on the performance of the product. When the mass parts of the components are further selected to be within the above-mentioned range, the obtained product has stronger acne-removing effect and cleaning ability, better mildness and better stability.

[0012] In one embodiment, the average particle size of the abrasive particles is 30-120 meshes.

[0013] The present invention has found that the average particle size of the abrasive particles not only affects the stability of the system but also affects the cleaning ability of the product; when the average particle size of the abrasive particles is further selected to be within the above range, the overall performance of the obtained product is better.

[0014] In one embodiment, the average diameter of the microcrystalline cellulose is 15-220 μm.

[0015] In one embodiment, the cellulose gum has a weight average molecular weight of 250,000-395,000 and a degree of substitution of 0.7-0.9.

[0016] The present invention has found that the average diameter of the microcrystalline cellulose in the suspending agent and the weight-average molecular weight and degree of substitution of the cellulose gum will also affect the stability of the system, and will also affect the coordination effect between the microcrystalline cellulose and the abrasive particles and the acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, thereby affecting the cleaning ability of the product. When the average diameter of the microcrystalline cellulose and the weight-average molecular weight and degree of substitution of the cellulose gum are further selected to be within the above ranges, the overall performance of the obtained product is better.

[0017] In one embodiment, in the suspending agent, the mass ratio of microcrystalline cellulose to cellulose gum is (2-4):4.

[0018] The present invention found that the mass ratio of microcrystalline cellulose and cellulose gum in the suspending agent also affects the performance of the product. When the mass ratio of the two is further selected to be (2-4):4, the system can be better stabilized and the cleaning ability of the product can also be improved.

[0019] In one embodiment, the mass ratio of the abrasive particles, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and suspending agent is abrasive particles: acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer: suspending agent = 1: (0.3-0.5): 3

[0020] The present invention has found that since the scrub particles expand after absorbing water to form a high-viscosity system, the acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer in the present invention can effectively fill the pores in the above-mentioned high-viscosity system, and the suspending agent can form a unique 3D network structure. When the mass ratio of the three is within the above-mentioned range, they can have good scrub effects while also having excellent stability and skin cleansing ability.

[0021] In one embodiment, the mass ratio of supramolecular capryloyl glycine, supramolecular salicylic acid, dihydroxypropyl arginine hydrochloride and glycerol glucoside is supramolecular capryloyl glycine: supramolecular salicylic acid: dihydroxypropyl arginine hydrochloride: glycerol glucoside = 1: (0.6-0.8): (0.1-0.3): (0.1-0.3).

[0022] The present invention has found that supramolecular capryloyl glycine and supramolecular salicylic acid, in combination with dihydroxypropyl arginine hydrochloride and glyceryl glucoside, can achieve a mild acne-removing and skin-cleansing effect, especially when the ratio of supramolecular capryloyl glycine: supramolecular salicylic acid: dihydroxypropyl arginine hydrochloride: glyceryl glucoside is further selected to be 1: (0.6-0.8): (0.1-0.3): (0.1-0.3), the overall effect of the obtained product is even better.

[0023] In one embodiment, the anti-acne scrub shower gel further comprises 0.1-6.2 parts of fruit acid, 0.05-0.2 parts of a soothing composition, and 0.01-2 parts of a pH regulator.

[0024] Research has found that adding 0.1-6.2 parts of fruit acid and 0.05-0.2 parts of a soothing composition to the acne-removing scrub body wash provided by the present invention can further enhance the cleansing ability of the body wash. Specifically, the introduction of fruit acid can increase the pH value of the overall product to between 5.0 and 6.0, which is close to the pH value of human skin. Therefore, the introduced fruit acid can effectively help remove the stratum corneum, deeply cleanse pores, and promote the absorption of other active ingredients, thereby improving the overall effectiveness of the product.

[0025] In one embodiment, the fruit acid includes at least one of lactic acid, glycolic acid, citric acid, and lactobionic acid.

[0026] In one embodiment, the fruit acid comprises the following components in parts by weight: 1-4.5 parts of lactic acid, 0.01-0.2 parts of glycolic acid, 0.01-0.5 parts of citric acid, and 0.01-0.5 parts of lactobionic acid.

[0027] In one embodiment, the soothing composition includes bisabolol and ginger root extract.

[0028] In one embodiment, the mass ratio of bisabolol to ginger root extract is 20:(0.01-1).

[0029] In one embodiment, the ginger root extract is prepared by placing ginger root in a grinder to produce ginger root powder, which is then placed in an extraction kettle. Under specific pressure and temperature conditions, CO2 is liquefied and passed through the extraction kettle containing the ginger root powder. The ginger root powder and liquid CO2 interact, dissolving the target substance in the liquid CO2. Subsequently, by adjusting temperature and pressure, the liquid CO2 undergoes a phase change, allowing the ginger root extract to be separated.

[0030] The present invention has been found that by further simultaneously introducing fruit acid and a soothing composition into the system of the present invention, the cleaning ability of the product can be enhanced while avoiding the irritation of the fruit acid, thereby achieving a good comprehensive effect of the product.

[0031] In one embodiment, the moisturizing agent includes at least one of sorbitol, betaine, and D-panthenol.

[0032] In one embodiment, the moisturizing agent comprises sorbitol, betaine and D-panthenol.

[0033] The present invention has found that the introduction of sorbitol can effectively improve the tightness after washing and enhance the user experience; betaine has excellent moisturizing ability, can help the skin absorb and lock in moisture, keep the skin hydrated, and at the same time, betaine also has certain anti-inflammatory and anti-allergic effects, can reduce the irritation of acne-removing active substances, fruit acids and surfactants, alleviate the skin's inflammatory response, soothe sensitive skin, and reduce skin discomfort; D-panthenol is a form of vitamin B5, has excellent moisturizing ability, can help the skin absorb and retain moisture, and improve dry skin problems. At the same time, D-panthenol also has the effect of repairing the skin, can reduce skin inflammation and redness caused by other irritants, promote the skin's natural repair process, and make the skin healthier and smoother; therefore, when the moisturizers are further selected as the above three substances, the comprehensive effect of the obtained product is more excellent.

[0034] In one embodiment, the surfactant includes at least one of sodium olefin sulfonate, lauroyl sarcosinate surfactant, and alkyl glycoside surfactant.

[0035] In one embodiment, the sodium olefin sulfonate includes sodium C14-16 olefin sulfonate.

[0036] In one embodiment, the lauroyl sarcosinate surfactant includes sodium lauroyl sarcosinate.

[0037] In one embodiment, the alkyl glycoside surfactant includes at least one of octyl / decyl glucoside, decyl glucoside, and coconut glucoside.

[0038] The present invention has found that when the surfactant is further selected as at least one of sodium olefin sulfonate, lauroyl sarcosinate surfactant, and alkyl glycoside surfactant, the obtained surfactant system has good compatibility with other components and also has good foaming performance in the system of the present invention.

[0039] In one embodiment, the chelating agent includes at least one of disodium EDTA and tetrasodium diethylamine glutamate.

[0040] In one embodiment, the preservative includes at least one of phenoxyethanol and sodium benzoate.

[0041] In one embodiment, the pH adjuster comprises sodium hydroxide.

[0042] In a second aspect of the present invention, the present invention provides a method for preparing the acne-removing scrub shower gel, the preparation method comprising the following steps:

[0043] (1) After mixing and dispersing the phase A materials evenly, add the phase B and phase C materials, stir and heat, then add the phase D materials and stir;

[0044] (2) After the first cooling, add the E phase material and disperse it evenly. Then, after the second cooling, add the F phase material and disperse it evenly. Then, after the third cooling, add the G phase material and disperse it evenly. Finally, after the fourth cooling, add the H phase material, the I phase material, and the J phase material in sequence and disperse them evenly.

[0045] (3) slowly adding the K phase material to the surface of the material in step (2) and dispersing it evenly to obtain an anti-acne scrub shower gel;

[0046] The phase A material includes part of deionized water and acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer;

[0047] The phase B material includes a portion of a moisturizer and a chelating agent;

[0048] The phase C material includes a suspending agent;

[0049] The phase D material includes a surfactant;

[0050] The phase E material includes supramolecular capryloyl glycine, supramolecular salicylic acid and a soothing composition;

[0051] The phase F material includes a pH regulator and the remaining portion of deionized water;

[0052] The G phase material includes the remaining portion of the moisturizer;

[0053] The H phase material includes fruit acid;

[0054] The phase I material includes preservatives, glyceryl glucoside and dihydroxypropyl arginine hydrochloride;

[0055] The J-phase material includes abrasive particles.

[0056] The acne-removing scrub shower gel prepared by the preparation method provided by the present invention has excellent comprehensive effects.

[0057] In one embodiment, in step (1), the stirring and heating temperature is 80-85° C., and the stirring time for adding the phase D material is 25-35 minutes.

[0058] In one embodiment, in step (2), the temperature after the first cooling is 70-75°C, the temperature after the second cooling is 60-65°C, the temperature after the third cooling is 50-55°C, and the temperature after the fourth cooling is 40-45°C.

[0059] Compared with the prior art, the present invention has the following beneficial effects:

[0060] The acne-removing scrub shower gel provided by the present invention can achieve good acne-removing and cleaning effects by selecting appropriate components and the mass fractions of the components, and the components work together. In addition, the shower gel has good stability and mildness on the basis of having a scrub effect. DETAILED DESCRIPTION

[0061] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0062] Unless otherwise specified, the reagents, methods and equipment used in the present invention are all conventional reagents, methods and equipment in the art; and unless otherwise specified, the raw materials used are from the same batch.

[0063] Mannan 1: average particle size is 60 mesh;

[0064] Mannan 2: average particle size is 200 mesh;

[0065] Sodium polyacrylate: average particle size is 60 mesh;

[0066] Suspending agent: Shanghai Huanqiu Industrial Development Co., Ltd., brand: Supcare MCF, wherein the suspending agent includes microcrystalline cellulose and cellulose gum, the mass ratio of microcrystalline cellulose to cellulose gum is 3:4, the average diameter of the microcrystalline cellulose is 180 μm, the weight-average molecular weight of the cellulose gum is 250,000, and the degree of substitution is 0.7;

[0067] Microcrystalline cellulose: German JRS, brand: CSTEXEasy, average diameter 180 μm;

[0068] Ginger root extract: derived from natural plant ginger root, Dezhixin Flavors and Fragrances (Nantong) Co., Ltd., brand: Ginfuse;

[0069] Acrylates / C10-30 Alkyl Acrylate Crosspolymer: Lubrizol Advanced Materials, Inc., brand SC-800POLYMER;

[0070] Supramolecular capryloylglycine: Nanjing Huashi New Materials Co., Ltd., brand name EverPro LCY ZMED;

[0071] Supramolecular salicylic acid: Nanjing Huashi New Materials Co., Ltd. and / or Guangdong Xuanjia Medical Health Technology Co., Ltd., brand: EverPro LCY ZMED and / or Xuandouqing.

[0072] Examples 1-8

[0073] The embodiment of the present invention provides an anti-acne scrub shower gel, the components (mass percentage) of the anti-acne scrub shower gel are shown in Table 1;

[0074] Table 1

[0075]

[0076]

[0077] The preparation method of the acne-removing scrub shower gel provided in Example 8 comprises the following steps:

[0078] (1) After mixing and dispersing the phase A materials evenly, add the phase B and phase C materials, stir and heat to 80-85°C, keep warm for 30 minutes, then add the phase D materials and stir evenly;

[0079] (2) After the first cooling to 70-75°C, add the E phase material and disperse it evenly. Then, after the second cooling to 60-65°C, add the F phase material and disperse it evenly. Then, after the third cooling to 50-55°C, add the G phase material and disperse it evenly. Finally, after the fourth cooling to 40-45°C, add the H phase material and the I phase material in sequence and stir and disperse them evenly.

[0080] (3) Slowly add the J phase material to the surface of the material in step (2) and disperse it evenly to obtain an anti-acne scrub shower gel.

[0081] The preparation methods of the acne-removing scrub shower gels provided in Examples 1-7 are consistent with those in Example 8, except that no relevant components are added.

[0082] Example 9

[0083] The embodiment of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that sodium polyacrylate is used instead of mannan 1.

[0084] Example 10

[0085] The embodiment of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that mannan 2 is used instead of mannan 1.

[0086] Comparative Example 1

[0087] The comparative example of the present invention provides an acne-removing scrub shower gel, the only difference between the acne-removing scrub shower gel and Example 1 is that no acne-removing scrub shower gel is added. SC-800POLYMER, make up the amount of suspending agent.

[0088] Comparative Example 2

[0089] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that supramolecular capryloyl glycine is not added, and the amount of supramolecular salicylic acid is supplemented.

[0090] Comparative Example 3

[0091] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that glyceryl glucoside is not added, and the amount of dihydroxypropyl arginine hydrochloride is used to make up for it.

[0092] Comparative Example 4

[0093] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that walnut shell particles are used instead of mannan 1.

[0094] Comparative Example 5

[0095] The comparative example of the present invention provides an acne-removing scrub shower gel, the only difference between the acne-removing scrub shower gel and Example 1 is that SF-1 is used instead of SC-800POLYMER.

[0096] Comparative Example 6

[0097] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that microcrystalline cellulose is used instead of the suspending agent.

[0098] Comparative Example 7

[0099] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that monomeric salicylic acid is used instead of supramolecular salicylic acid.

[0100] Comparative Example 8

[0101] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that polyquaternium-6 is used instead of dihydroxypropyl arginine hydrochloride.

[0102] Comparative Example 9

[0103] The comparative example of the present invention provides an acne-removing scrub shower gel. The only difference between the acne-removing scrub shower gel and Example 1 is that glycerol is used instead of glyceryl glucoside.

[0104] Effect Examples

[0105] The efficacy of the acne-removing scrub shower gel prepared in Examples 1-10 and Comparative Examples 1-9 is verified, specifically including the following aspects:

[0106] 1. Stability test

[0107] Stability testing includes the following steps:

[0108] The acne-removing scrub shower gels prepared in Examples 1-10 and Comparative Examples 1-9 were weighed into 8 25 g samples each in a transparent PET bottle, and placed under constant temperature conditions of -18°C, -8°C, 5°C, 25°C (room temperature), 40°C, 45°C, 50°C, and cycled (-8°C to 40°C, one cycle every 2 days) for 90 days. After returning to room temperature, the stability was observed. The scoring test results are shown in Table 2 below. The stability judgment criteria are as follows: after the test sample is returned to room temperature, if there is any particle sinking, precipitation and agglomeration (aggregation into jelly), and if the transparency does not change, it is considered normal; otherwise, it is considered abnormal.

[0109] The test results are shown in Table 2;

[0110] Table 2

[0111]

[0112]

[0113] As can be seen from Table 2, when the technical solution of the present invention is adopted, the obtained product has excellent stability.

[0114] 2. Irritation test

[0115] Since the stability of the products obtained in Comparative Example 1 and Comparative Examples 5-6 is too poor, this effect example does not explore the irritation of the products obtained in Comparative Example 1 and Comparative Examples 5-6;

[0116] 2.1 Acute eye irritation test

[0117] 2.1.1 Test material: the anti-acne scrub shower gel prepared in Examples 1-10, Comparative Examples 2-4, and Comparative Examples 7-9. The samples were used directly without being treated.

[0118] 2.2.2 Experimental Animals and Housing Environment: Experimental animals: Three female, standard-grade New Zealand rabbits, weighing 2.16–2.33 kg. Eye examination showed no abnormalities. Experimental animals were purchased from Xinhua Experimental Animal Farm, Huadong, Huadu District, Guangzhou. Laboratory Animal Production License Number: SCXK(Guangdong)2024-0023, Quality Certificate Number: 44007600011794. Housing Environment: Temperature: 18–26°C, relative humidity: 40–70%. Laboratory Animal Use License Number: SYXK(Guangdong)2022-0198. Feed: Purchased from Qingdao Kangda Aibo Biotechnology Co., Ltd., Certificate Number: 3708702400052334.

[0119] 2.2.3 Test method: Chapter 6 (5) of the Technical Specifications for Safety of Cosmetics (2015 edition).

[0120] 2.2.3.1 Exposure: Gently pull open the lower eyelid of one rabbit and instill 0.1 mL of the test substance into the conjunctival sac of each rabbit. Close the upper and lower eyelids passively for 1 second. At the 30th second mark, flush with sufficient, but not damaging, water for 30 seconds. The other eye remains untreated as a control. After the 24-hour observation and recording period, all animals undergo further eye examination using sodium fluorescein.

[0121] 2.2.3.2 Animal Observation: Examine the eyes of the animals at 1, 24, 48, 72 hours, on the 4th day, and on the 7th day after instilling the test substance. If no irritation reaction occurs within 72 hours, the test can be terminated. If corneal involvement or other eye irritation effects are found and do not recover within 7 days, the observation time needs to be extended to determine the reversibility or irreversibility of the damage, generally not exceeding 21 days, and observation reports for 7 days, 14 days, and 21 days should be provided. In addition to observing the cornea, iris, and conjunctiva, other damage effects should be recorded and reported. The integral of the eye irritation reaction should be recorded according to the eye damage scoring criteria in each examination.

[0122] Evaluate based on the integral mean of the irritation reaction scores of the animal cornea, iris, or conjunctiva at the 24-hour, 48-hour, and 72-hour observation points after instilling the test substance and the recovery time, and determine the irritation intensity of the test substance to the eyes according to the classification of eye irritation reactions. Among them, the eye damage scoring criteria are shown in Table 3, and the classification of the product eye irritation reaction is shown in Table 4;

[0123] Table 3

[0124]

[0125]

[0126] Table 4

[0127]

[0128] The test results are shown in Table 5;

[0129] Table 5

[0130] Irritation response grading Irritation response grading Example 1 Slightly irritating Comparative Example 2 Mild irritation Example 2 Mild irritation Comparative Example 3 Mild irritation Example 3 Mild irritation Comparative Example 4 Slightly irritating Example 4 Mild irritation Comparative Example 7 Irritation Comparative Example 8 Mild irritation Example 6 Slightly irritating Comparative Example 9 Mild irritation Example 7 Slightly irritating Example 8 Non-irritating Example 9 Slightly irritating Example 10 Slightly irritating

[0131] 2.2 Acute Skin Irritation Test

[0132] 2.2.1. Test Substance: Light yellow particle-containing semi-transparent viscous liquid, the sample is used directly without treatment.

[0133] 2.2.2. Experimental Animals and Rearing Environment:

[0134] Experimental Animals: 4 ordinary-grade New Zealand rabbits, female, non-pregnant, never given birth, weighing 2.02 - 2.28 kg, with intact and normal skin upon examination. The experimental animals were purchased from Huadong Xinhua Experimental Animal Farm in Huadu District, Guangzhou. The production license number of the experimental animals: SCXK(Guangdong)2024 - 0023, quality certificate number: No.44007600011794.

[0135] Rearing Environment: Temperature is 18 - 26 °C, relative humidity is 40 - 70%, and the experimental animal use license number: SYXK(Guangdong)2022 - 0198.

[0136] Feed: purchased from Qingdao Kangda Aibo Biotechnology Co., Ltd., certificate number: 3708702400052334.

[0137] 2.2.3. Test method: Chapter 6 (4) of the Technical Specifications for Safety of Cosmetics (2015 edition).

[0138] 2.2.3.1 Animal Handling: Approximately 24 hours before the experiment, the hair on both sides of the spine of the experimental animals should be trimmed without damaging the epidermis. The hair removal area should be approximately 3 cm × 3 cm on the left and right sides.

[0139] 2.2.3.2 Exposure: Apply 0.5 mL of the test substance directly to the hairless area of ​​skin. Cover with two layers of medical gauze (2.5 cm × 2.5 cm) and a layer of oil-proof paper. Secure with a non-irritating medical bandage. The other side of the skin serves as a control. Maintain an occlusive application for 2 hours. After the test, remove any remaining test substance with warm water.

[0140] 2.2.3.3 Animal Observation: Observe skin reactions at the application site 1 hour, 24 hours, 48 ​​hours, and 72 hours after removal of the test substance. Skin reactions are scored according to the skin irritation scoring criteria. The average score of the test animals is used for comprehensive evaluation. The skin irritation intensity is determined according to the skin irritation intensity grading table based on the average of the highest scores at each observation time point (24 hours, 48 ​​hours, and 72 hours). The observation period should be sufficient to observe the entire process of reversible or irreversible irritation, generally not exceeding 14 days.

[0141] Among them, the skin irritation reaction classification is shown in Table 6, and the skin irritation intensity classification is shown in Table 7;

[0142] Table 6

[0143]

[0144]

[0145] Table 7

[0146] Integral mean strength 0-＜0.5 Non-irritating 0.5-＜2.0 Mild irritation 2.0-＜6.0 Moderate irritation 6.0-8.0 Strong irritation

[0147] The results are shown in Table 8;

[0148] Table 8

[0149] Irritation response grading Irritation response grading Example 1 Non-irritating Comparative Example 2 Mild irritation Example 2 Non-irritating Comparative Example 3 Mild irritation Example 3 Non-irritating Comparative Example 4 Non-irritating Example 4 Non-irritating Comparative Example 7 Moderate irritation Comparative Example 8 Mild irritation Example 6 Non-irritating Comparative Example 9 Mild irritation Example 7 Non-irritating Example 8 Non-irritating Example 9 Non-irritating Example 10 Non-irritating

[0150] 2.3 Human skin patch test:

[0151] The acne-removing scrub body wash prepared in Examples 1-10, Comparative Examples 2-4, and Comparative Examples 7-9 was administered to 30 volunteers. 0.020-0.025 ml of the test substance was placed in a spot tester and applied to the flexed forearm of the subject using hypoallergenic tape. The test substance was removed after 24 hours. Skin reactions were observed 0.5, 24, and 48 hours after removal. The results were recorded according to the skin reaction grading standards in the "Safety Technical Specifications for Cosmetics" (2015 edition). The identification criteria for the skin irritation test are shown in Table 9.

[0152] Table 9

[0153]

[0154]

[0155] The results are shown in Table 10;

[0156] Table 10

[0157]

[0158]

[0159]

[0160] It can be seen from Table 5, Table 8 and Table 10 that when the technical solution of the present invention is adopted, the product obtained has low irritation and good mildness.

[0161] 3. Cleaning ability test

[0162] The cleaning ability test includes the following steps:

[0163] Since the stability of the products obtained in Comparative Example 1 and Comparative Examples 5-6 is too poor, and since the eye irritation in Comparative Example 7 is too high, this effect example does not explore the cleaning ability of the products obtained in Comparative Examples 1 and Comparative Examples 5-7;

[0164] At least 150 subjects were selected and evenly divided into 15 test groups, each test group containing 10 subjects. Standard sebum containing carbon black was applied to the inner arms of the subjects, and then the subjects were cleaned with the acne-removing scrub shower gels prepared in Examples 1-10 and Comparative Examples 2-4 and Comparative Examples 8-9, respectively. The chromaticity ratio before and after cleaning was measured, and the chromaticity before cleaning remained consistent. The obtained chromaticity ratios before and after cleaning are shown in Table 11, where a higher chromaticity ratio indicates better cleaning ability.

[0165] ΔE1=sqrt((L0-L1) 2 +(a0-a1) 2 +(b0-b1) 2 )

[0166] ΔE2=sqrt((L0-L2) 2 +(a0-a2) 2 +(b0-b2) 2 )

[0167] ΔE1: skin chromaticity difference after applying carbon black sebum;

[0168] ΔE2: skin color difference immediately after washing;

[0169] L0: basic skin brightness;

[0170] L1: skin brightness after applying carbon black sebum;

[0171] L2: Skin brightness immediately after cleansing;

[0172] a0: base skin redness;

[0173] a1: skin redness after applying carbon black sebum;

[0174] a2: Skin redness immediately after cleansing

[0175] b0: basic value of skin yellowness;

[0176] b1: skin yellowness after applying carbon black sebum;

[0177] B2: skin yellowness immediately after washing;

[0178] Cleaning rate = (ΔE1-ΔE2) / ΔE1

[0179] Table 11

[0180]

[0181]

[0182]

[0183] It can be seen from Table 11 that when the technical solution of the present invention is adopted, the obtained product has a good cleaning effect.

[0184] 4. Antibacterial test of Propionibacterium acnes

[0185] Since the stability of the products obtained in Comparative Example 1 and Comparative Examples 5-6 was too poor, and the eye irritation in Comparative Example 7 was too high, this effect example did not explore the antibacterial effect of the products obtained in Comparative Examples 1 and Comparative Examples 5-7 on Propionibacterium acnes;

[0186] Test group: acne-removing scrub shower gels prepared in Examples 1-10, Comparative Examples 2-4, and Comparative Examples 8-9;

[0187] With reference to WS / T 650-2019, the inhibition ring test was used. A 24-hour fresh slant culture of P. acnes was washed with PBS and diluted to 5.0×10 5 CFU / mL-5.0×10 6 CFU / mL is reserved.

[0188] Preparation of antibacterial sheets: Cut filter paper sheets with a diameter of 5 mm and a thickness of no more than 4 mm, and immerse each group of 4 sheets in 10 mL of sample solution.

[0189] Preparation of negative control samples: Take samples of the same material, make discs (blocks) of the same size as the test group, and soak them in sterile water.

[0190] A sterile cotton swab was dipped in a solution of 5.0×10 5 CFU / mL-5.0×10 6 Apply CFU / mL of P. acnes suspension evenly three times on the surface of a suitable culture medium plate. Each time you apply it, the plate should be rotated 60°, and finally the cotton swab should be applied around the edge of the plate. Cover the plate and let it dry at room temperature for 5 minutes. Place one infected plate for each test, with four test samples and one negative control sample on each plate, for a total of five samples. Use sterile tweezers to take the sample and place it on the surface of the plate. The negative control sample should be placed in the center of the plate, and the test sample should be placed on the four sides. After placing it, use sterile tweezers to gently press the sample to make it stick to the surface of the plate. The centers of each sample should be at least 25 mm apart, and at least 15 mm away from the edge of the plate. Cover the plate, incubate at 36℃±1℃ for 16-18 hours, and observe the results. Repeat the test three times. Use a vernier caliper to measure the diameter of the antibacterial ring (including the patch) and record it. When measuring the antibacterial ring, a uniform and completely sterile antibacterial ring should be selected, and the diameter should be measured based on the outer edge of the antibacterial ring.

[0191] The negative control sample should produce no inhibition ring. If the diameter of the inhibition ring on the test sample is greater than 7 mm, it is considered to have an antibacterial effect; if the diameter of the inhibition ring is ≤ 7 mm, it is considered to have no antibacterial effect. If the inhibition effect is observed in all three repeated tests, the test is considered qualified. The specific results are shown in Table 12.

[0192] Table 12

[0193]

[0194]

[0195] As can be seen from Table 12, when the technical solution of the present invention is adopted, the obtained product has excellent antibacterial ability against Propionibacterium acnes.

[0196] 5. Acne removal ability test

[0197] Since the stability of the products obtained in Comparative Example 1 and Comparative Examples 5-6 is too poor, and the eye irritation in Comparative Example 7 is too high, this effect example does not explore the acne-removing ability of the products obtained in Comparative Examples 1 and Comparative Examples 5-7;

[0198] The acne removal ability test includes the following steps:

[0199] Tested substances: Anti-acne scrub shower gels prepared in Examples 1-10, Comparative Examples 2-4 and Comparative Examples 8-9 Control: Before and after comparison of the body itself

[0200] Subjects: Each group consisted of 15 healthy men or women aged 18-45 years, in good general health with no major systemic diseases. They had two or more acne patches on their backs and had not used steroids or immunosuppressants in the past month.

[0201] Test area: back.

[0202] Instrument measurement parameters and related equipment:

[0203]

[0204] Test environment: temperature: 20℃822℃, humidity: 40%~60%, and real-time dynamic monitoring.

[0205] Purpose and Principle of the Trial: Fifteen subjects were recruited to use the test sample for 28 consecutive days. The improvement level of acne lesions was evaluated subjectively and by a doctor. Antera 3D was used to collect and analyze the corresponding parameters of acne on the subjects' backs. The changes in various indicators before and after use were compared to determine the acne-removing effect of the product.

[0206] Experimental design principles: double-blind, randomized, and self-controlled.

[0207] Pre-test preparation: No products should be used on the test area on the day of the test. Before the test, subjects should sit quietly in the human efficacy evaluation room (temperature: 20°C-22°C, humidity: 40%-60%) for 30 minutes without drinking any water or other beverages. Subjects should remain relaxed and avoid touching their backs. Before the test, subjects should be briefed on the test and sign an informed consent form.

[0208] Product Usage: When bathing, apply an appropriate amount of the test product instead of your usual bath product, gently massage all over your body, and then rinse thoroughly. Use once daily for 28 consecutive days. During the trial, subjects are prohibited from using acne-fighting, anti-inflammatory, or antibacterial medications. Subjects are also prohibited from using intravenous drips, injections, oral administration, or other forms of ingestion that could affect acne treatment. Subjects should primarily remain indoors and avoid prolonged exposure to outdoor sunlight.

[0209] Subjective Evaluation: During a follow-up visit 28 days after using the product (D28), participants completed a questionnaire to evaluate their back condition and recorded their scores. Using a 7-point scale, the product was rated based on skin feel, effectiveness, mildness, and user satisfaction. This was then evaluated and recorded at each follow-up visit.

[0210] Semi-quantitative evaluation (physician assessment): Dermatologists evaluated the acne lesions on the subjects' backs (photographed) before product use (D0) and 28 days after use (D28). The improvement in lesion symptoms before and after use was scored using the ISGA scale (Table 2), and the percentage reduction in lesions was calculated.

[0211] Objective quantitative evaluation: After a 30-minute rest in the human efficacy evaluation room, subjects were photographed using an Antera 3D Skin Image Analyzer at the location of acne on their backs. Software analysis determined the average acne volume within the measured area, which served as the baseline value (D0). The product was then distributed and instruction on how to use the product was provided. Subjects were revisited 28 days after using the product (D28) for the same performance indicators.

[0212] Average acne volume reduction rate = (average acne volume before using the product - average acne volume after using the product) / average acne volume before using the product × 100%

[0213] The results are shown in Table 13;

[0214] Table 13

[0215]

[0216]

[0217] As can be seen from Table 13, when the technical solution of the present invention is adopted, the obtained product has an excellent acne-removing effect.

[0218] 6. Volunteer sensory evaluation

[0219] Collect the scores of volunteers in the acne test, scoring standard (self-rating value standard (7-level scoring method)

[0220] ) is shown in Table 14, and the results are shown in Table 15; Table 15 records the recognition rate, that is, the percentage of volunteers with a score of ≥5 points in the total number of test volunteers in each group;

[0221] Table 14

[0222]

[0223] Table 15

[0224]

[0225]

[0226] As can be seen from Table 15, when the technical solution of the present invention is adopted, the obtained product has a good usage evaluation.

[0227] Finally, it should be noted that the above embodiments are intended to illustrate the technical solutions of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. An anti-acne scrub shower gel, characterized in that: The acne-removing scrub shower gel is composed of the following components in parts by weight: 0.1-2 parts of scrub particles, 0.3-0.5 parts of acrylates / C10-30 alkyl acrylate cross-polymer, 2-4 parts of suspending agent, 0.1-3 parts of supramolecular capryloyl glycine, 0.1-3 parts of supramolecular salicylic acid, 0.05-0.5 parts of dihydroxypropyl arginine hydrochloride, 0.05-0.5 parts of glyceryl glucoside, 2-10 parts of moisturizing agent, 12-26 parts of surfactant, 0.01-0.1 parts of chelating agent, 1 part of preservative, 40-80 parts of deionized water, 0.1-6.2 parts of fruit acid, 0.05-0.2 parts of soothing composition, and 0.01-2 parts of pH regulator; The preservatives are 0.5 parts of phenoxyethanol and 0.5 parts of sodium benzoate; The scrub particles are mannan or sodium polyacrylate; The suspending agent is Supcare MCF, which includes microcrystalline cellulose and cellulose gum; The average particle size of the frosted particles is 60 mesh; The average diameter of the microcrystalline cellulose is 15-220 μm; The cellulose gum has a weight average molecular weight of 250,000-395,000 and a degree of substitution of 0.7-0.9; The mass ratio of the abrasive particles, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer and suspending agent is abrasive particles: acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer: suspending agent = 1: (0.3-0.5): 3; The mass ratio of the supramolecular capryloyl glycine, supramolecular salicylic acid, dihydroxypropyl arginine hydrochloride and glycerol glucoside is supramolecular capryloyl glycine: supramolecular salicylic acid: dihydroxypropyl arginine hydrochloride: glycerol glucoside = 1: (0.6-0.8): (0.1-0.3): (0.1-0.3).

2. The anti-acne scrub shower gel according to claim 1, characterized in that The mass ratio of the microcrystalline cellulose to the cellulose gum is microcrystalline cellulose:cellulose gum=(2-4):

4.

3. The anti-acne scrub shower gel according to claim 1, characterized in that At least one of the following is met: a. The moisturizing agent comprises at least one of sorbitol, betaine, and D-panthenol; b. The surfactant includes at least one of sodium olefin sulfonate, lauroyl sarcosinate surfactant, alkyl glycoside surfactant, and amphoteric surfactant; c. The chelating agent comprises at least one of disodium EDTA and tetrasodium diethylamine glutamate; e. The pH regulator includes at least one of sodium hydroxide and potassium hydroxide.

4. The method for preparing the acne-removing scrub shower gel according to claim 3, wherein: The preparation method comprises the following steps: (1) After mixing and dispersing the phase A materials evenly, add the phase B and phase C materials, stir and heat, then add the phase D materials and stir; (2) After the first cooling, add the E phase material and disperse it evenly. Then, after the second cooling, add the F phase material and disperse it evenly. Then, after the third cooling, add the G phase material and disperse it evenly. Finally, after the fourth cooling, add the H phase material and the I phase material in sequence and disperse them evenly. (3) Slowly add the J phase material to the surface of the material in step (2) and disperse evenly to obtain an anti-acne scrub shower gel; The phase A material includes a portion of deionized water and acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer; The phase B material includes a portion of a moisturizer and a chelating agent; The phase C material includes a suspending agent; The phase D material includes a surfactant; The phase E material includes supramolecular capryloyl glycine, supramolecular salicylic acid and a soothing composition; The phase F material includes a pH regulator and the remaining portion of deionized water; The G phase material includes the remaining portion of the moisturizer; The H phase material includes fruit acid; The phase I material includes preservatives, glyceryl glucoside and dihydroxypropyl arginine hydrochloride; The J-phase material includes abrasive particles.

5. The preparation method according to claim 4, characterized in that In step (1), the stirring temperature is 80-85°C, and the stirring time for adding the D phase material is 25-35 minutes; And / or, in step (2), the temperature after the first cooling is 70-75°C, the temperature after the second cooling is 60-65°C, the temperature after the third cooling is 50-55°C, and the temperature after the fourth cooling is 40-45°C.

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