An anti-tumor composite dressing and its preparation method

Abstract

The present invention relates to the technical field of tumor treatment, and specifically provides an anti-tumor composite dressing and a preparation method thereof. The anti-tumor composite dressing includes: the traditional Chinese medicine extract and beeswax with a mass 0.05 times that of the traditional Chinese medicine extract. The anti-tumor composite dressing of the present invention mainly promotes blood circulation to dissipate stasis and secondarily activates the heart and promotes blood circulation, promotes the immune cycle, delays or even alleviates thyroid tumors, and finally achieves the goal of not undergoing surgery and maintaining a relatively normal thyroglobulin content for a long time.

Description

Technical Field

[0001] The present invention relates to the technical field of tumor treatment, and particularly relates to an anti-tumor composite dressing and a preparation method thereof. Background Art

[0002] Traditional Chinese medicine application therapy is a traditional Chinese medicine therapy. The principle of traditional Chinese medicine application has not been clearly explained. The mainstream view is that the applied medicine enables the drug components to be absorbed through the skin pores and acupoints, penetrate into the body, stimulate the acupoints, participate in the body regulation, and thus treat diseases.

[0003] The medicine applied to the skin can be absorbed through the skin and enter the body to play a role. When applying, the local area is in a state of "qi being closed and not leaking", and the skin temperature rises, accelerating the local blood circulation. If the medicine has strong penetrability and running property, it can also play the role of guiding the medicine into the meridian, making the medicine used in the application easy to enter the blood circulation, be absorbed by the body, and play the corresponding role. Modern medicine believes that after the medicine is absorbed through the skin, it does not pass through the digestive tract and rarely undergoes liver metabolism, but directly enters the blood circulation, can quickly reach a high blood drug concentration locally, treat local lesions, and at the same time avoid the decomposition and destruction of various digestive enzymes in the digestive tract on the drug components, so that more effective components of the medicine can be maintained and better play the treatment role in the body. In addition, it also avoids the irritation to the gastrointestinal tract caused by oral drugs when absorbed through the gastrointestinal tract, thus avoiding the adverse reactions caused by the gastrointestinal tract.

[0004] Thyroid tumor is a common tumor, with a mass in the front of the neck as the main symptom. The mass has benign and malignant types. Among them, the benign tumor is mainly an adenoma. If surgery is required, the thyroid gland needs to be cleared and lifelong medication is needed. However, it is expected to delay or even relieve the symptoms through application, and ultimately achieve no surgery and long-term maintenance of benignity. Since the volume of thyroid benign tumor changes slowly, the condition is generally characterized by detecting the content of thyroglobulin in the blood. The closer the content of thyroglobulin is to the normal value of 15 μg / L, the better the treatment effect.

[0005] Therefore, an anti-tumor composite dressing and a preparation method thereof are needed. Summary of the Invention

[0006] In order to solve the above problems, the purpose of the present invention is to provide an anti-tumor composite dressing and a preparation method thereof.

[0007] On the one hand, the present invention provides a preparation method of an anti-tumor composite dressing, and the preparation method of the anti-tumor composite dressing includes the following steps:

[0008] Step 1: Take oyster with a mass fraction of 22 - 29%, Scrophulariae Radix with a mass fraction of 20 - 27%, Trionycis Carapax with a mass fraction of 11 - 16%, Scorpio with a mass fraction of 8 - 12%, Agkistrodon with a mass fraction of 6 - 10%, Bufonis Venenum with a mass fraction of 3 - 5%, and make up the remaining mass fraction with pure water. Chop the above medicinal materials and pass them through a 20 - mesh sieve. Add 85% ethanol with a mass 10 times that of the total mass of the medicinal materials and water, immerse them at 63°C for 40 h. Pour the solid - liquid mixture into an ultrafine grinder, with a crushing temperature of 10°C and a main shaft rotation speed of 960 r / min. After discharging, filter through a 200 - mesh sieve to obtain a roughly filtered extract. Add pure water with a mass 0.2 times that of the roughly filtered extract, and then perform vacuum distillation in a rotary evaporator at 38°C and a pressure of 120 mbar until the mass is 0.1 times that before distillation. Collect the remaining liquid to obtain a Chinese medicine extract;

[0009] Step 2: Melt beeswax at 65°C for standby. Rapidly stir the Chinese medicine extract and beeswax with a mass 0.05 times that of the Chinese medicine extract at 50°C until emulsified and mixed to obtain the anti - tumor composite dressing.

[0010] Further, the mass fraction of the oyster is 26%.

[0011] Further, the mass fraction of the Scrophulariae Radix is 25%.

[0012] Further, the mass fraction of the Trionycis Carapax is 14%.

[0013] Further, the mass fraction of the Scorpio is 10%.

[0014] Further, the mass fraction of the Agkistrodon is 8%.

[0015] Further, the mass fraction of the Bufonis Venenum is 4%.

[0016] On the other hand, the present invention provides an anti - tumor composite dressing prepared by the preparation method of the anti - tumor composite dressing as described above. The anti - tumor composite dressing includes: the Chinese medicine extract and beeswax with a mass 0.05 times that of the Chinese medicine extract.

[0017] The present invention can bring the following beneficial effects:

[0018] The anti - tumor composite dressing of the present invention mainly focuses on dissipating stasis and resolving masses, supplemented by promoting blood circulation and strengthening the heart, promoting the immune circulation, delaying and even alleviating thyroid tumors, and ultimately achieving the goal of not undergoing surgery and maintaining a relatively normal thyroglobulin content for a long time.

[0019] Traditional Chinese medicine believes that the main pathogenesis of thyroid disease is liver depression and qi stagnation, endogenous phlegm and dampness, qi and blood stasis, and phlegm and dampness condensing in the front of the neck, which causes blood stasis over time, with qi, phlegm and blood stasis combined as a problem. The oyster of the present invention calms the mind and nourishes the liver and kidneys; Scrophularia nourishes yin, detoxifies, reduces swelling and disperses nodules; turtle shell nourishes yin, suppresses yang, softens and disperses nodules; scorpion clears the meridians, relieves pain, attacks toxins and disperses nodules, and its toxicity is reduced after alcohol extraction; Tianlong is also called gecko, which relieves pain and disperses nodules; toad venom reduces swelling and strengthens the heart. In order to cooperate with the application, the present invention also matches the scorpion and Tianlong with a suitable proportion. The above-mentioned components of Chinese medicine cooperate with each other under the process and ratio of the present invention to nourish yin, activate blood circulation, reduce swelling and disperse nodules, and finally achieve the anti-tumor treatment effect of the present invention.

[0020] Please note that although the oyster, Scrophularia, turtle shell, scorpion, dragon shell and toad venom of the present invention may have been used to treat tumors, it is the first time that the proportion and process of the present invention are used to treat thyroid tumors. The process parameters and drug proportions of the present invention cannot be obtained by simple experiments, and have a certain degree of randomness and creativity. DETAILED DESCRIPTION

[0021] In order to more clearly explain the overall concept of the present invention, the overall scheme of the present invention is described in detail in the form of embodiments below; in the following description, a large number of specific details are given to provide a more thorough understanding of the present invention; however, it is obvious to those skilled in the art that the present invention can be implemented without one or more of these details; in other examples, in order to avoid confusion with the present invention, some technical features known in the art are not described.

[0022] In the present invention, the ultrafine grinder was purchased from Shandong Baishun Machinery Co., Ltd., model BW-L100B; the rotary evaporator was purchased from Anhui Huixi Chemical Equipment Co., Ltd., model HX-0553; the water content of oyster, Scrophularia, turtle shell, scorpion, dragon and toad venom was 5%, all purchased from Anguo Yaoyuan Trading Co., Ltd.; beeswax was purchased from Hengshui Xinchangsheng Beeswax Co., Ltd. The silicone gel non-woven acupuncture point patch was purchased from Guangxi Dezhiran Biotechnology Co., Ltd., and there was a circular medicine pit inside to place the dressing.

[0023] Unless otherwise specified, all raw material components in the following examples can be purchased from commercial sources, the experimental instruments used are conventional laboratory experimental instruments, and the performance test methods are known in the art. The overall space environment is 25°C and the air humidity is 30%.

[0024] The preferred implementation is as follows:

[0025] Embodiment 1:

[0026] The preparation method of the anti-tumor composite dressing is as follows:

[0027] Step 1: Take oyster with a mass fraction of 26%, Scrophulariae Radix with a mass fraction of 25%, Amydae Carapax with a mass fraction of 14%, Scorpio with a mass fraction of 10%, Agkistrodon with a mass fraction of 8%, Venenum Bufonis with a mass fraction of 4%, and make up the remaining mass fraction with pure water. Chop the above-mentioned medicinal materials, pass 1 kg of them through a 20-mesh sieve, add 85% ethanol with a mass 10 times that of the total mass of the medicinal materials and water, immerse them at 63°C for 40 h. Pour the solid-liquid mixture into an ultrafine grinder, with a crushing temperature of 10°C and a main shaft rotation speed of 960 r / min. After discharging, filter through a 200-mesh sieve to obtain 9.6 kg of a roughly filtered extract; add pure water with a mass 0.2 times that of the roughly filtered extract, and then in a rotary evaporator at 38°C and a pressure of 120 mbar, batchwise reduce the pressure to distill according to the maximum usable capacity of the rotary evaporator until the mass is 0.1 times that before distillation, and collect the remaining liquid to obtain 1.2 kg of a traditional Chinese medicine extract, with the above masses accurate to 0.1 kg;

[0028] Step 2: Melt beeswax at 65°C for later use. Rapidly stir the traditional Chinese medicine extract and beeswax with a mass 0.05 times that of the traditional Chinese medicine extract at 50°C until emulsified and mixed to obtain the anti-tumor composite dressing.

[0029] The anti-tumor composite dressing is made from raw materials including the following proportions:

[0030] The traditional Chinese medicine extract and beeswax with a mass 0.05 times that of the traditional Chinese medicine extract.

[0031] Examples 2 - 13:

[0032] The difference between Example 2 and Example 1 is only that the mass fraction of oyster is 22%;

[0033] The difference between Example 3 and Example 1 is only that the mass fraction of oyster is 29%;

[0034] The difference between Example 4 and Example 1 is only that the mass fraction of Scrophulariae Radix is 20%;

[0035] The difference between Example 5 and Example 1 is only that the mass fraction of Scrophulariae Radix is 27%;

[0036] The difference between Example 6 and Example 1 is only that the mass fraction of Amydae Carapax is 11%;

[0037] The difference between Example 7 and Example 1 is only that the mass fraction of Amydae Carapax is 16%;

[0038] The difference between Example 8 and Example 1 is only that the mass fraction of Scorpio is 8%;

[0039] The difference between Example 9 and Example 1 is only that the mass fraction of Scorpio is 12%;

[0040] Example 10 is only different from Example 1 in that the mass fraction of Tianlong is 6%;

[0041] Example 11 is only different from Example 1 in that the mass fraction of Tianlong is 10%;

[0042] Example 12 is only different from Example 1 in that the mass fraction of Chan Su is 3%;

[0043] Example 13 is only different from Example 1 in that the mass fraction of Chan Su is 5%.

[0044] Comparative Examples 1-24:

[0045] Comparative Example 1 is only different from Example 1 in that the mass fraction of Oyster is 10%;

[0046] Comparative Example 2 is only different from Example 1 in that the mass fraction of Oyster is 35%;

[0047] Comparative Example 3 is only different from Example 1 in that the mass fraction of Scrophulariae Radix is 10%;

[0048] Comparative Example 4 is only different from Example 1 in that the mass fraction of Scrophulariae Radix is 35%;

[0049] Comparative Example 5 is only different from Example 1 in that the mass fraction of Amydae Carapax is 5%;

[0050] Comparative Example 6 is only different from Example 1 in that the mass fraction of Amydae Carapax is 25%;

[0051] Comparative Example 7 is only different from Example 1 in that the mass fraction of Scorpio is 4%;

[0052] Comparative Example 8 is only different from Example 1 in that the mass fraction of Scorpio is 18%;

[0053] Comparative Example 9 is only different from Example 1 in that the mass fraction of Tianlong is 3%;

[0054] Comparative Example 10 is only different from Example 1 in that the mass fraction of Tianlong is 15%;

[0055] Comparative Example 11 is only different from Example 1 in that the mass fraction of Chan Su is 1%;

[0056] Comparative Example 12 is only different from Example 1 in that the mass fraction of Chan Su is 8%;

[0057] Comparative Example 13 is only different from Example 1 in that in the preparation method of the traditional Chinese medicine extract, ethanol is immersed at 50 °C;

[0058] Comparative Example 14 is only different from Example 1 in that in the preparation method of the traditional Chinese medicine extract, ethanol is immersed at 75 °C;

[0059] The difference between Comparative Example 15 and Example 1 is only that in the preparation method of the traditional Chinese medicine extract, the temperature of vacuum distillation is 50 °C;

[0060] The difference between Comparative Example 16 and Example 1 is only that Scrophulariae Radix, Amydae Carapax, Scorpio, Agkistrodon and Venenum Bufonis are replaced with an equal mass of Ostreae Concha;

[0061] The difference between Comparative Example 17 and Example 1 is only that Ostreae Concha, Amydae Carapax, Scorpio, Agkistrodon and Venenum Bufonis are replaced with an equal mass of Scrophulariae Radix;

[0062] The difference between Comparative Example 18 and Example 1 is only that Ostreae Concha, Scrophulariae Radix, Scorpio, Agkistrodon and Venenum Bufonis are replaced with an equal mass of Amydae Carapax;

[0063] The difference between Comparative Example 19 and Example 1 is only that Ostreae Concha, Scrophulariae Radix, Amydae Carapax, Agkistrodon and Venenum Bufonis are replaced with an equal mass of Scorpio;

[0064] The difference between Comparative Example 20 and Example 1 is only that Ostreae Concha, Scrophulariae Radix, Amydae Carapax, Scorpio and Venenum Bufonis are replaced with an equal mass of Agkistrodon;

[0065] The difference between Comparative Example 21 and Example 1 is only that Ostreae Concha, Scrophulariae Radix, Amydae Carapax, Scorpio and Agkistrodon are replaced with an equal mass of Venenum Bufonis;

[0066] The difference between Comparative Example 22 and Example 1 is only that Scorpio and Agkistrodon are replaced with an equal mass of Ostreae Concha, Scrophulariae Radix, Amydae Carapax and Venenum Bufonis in the proportion of Example 1;

[0067] The difference between Comparative Example 23 and Example 1 is only that Scrophulariae Radix is replaced with an equal mass of Codonopsis Pilosulae Radix;

[0068] The difference between Comparative Example 24 and Example 1 is only that the traditional Chinese medicine extract is replaced with an equal mass of pure water.

[0069] Recruit male volunteers aged 35 with thyroid tumors equal to the number of examples in the present invention. Before this experiment, the thyroglobulin content in their respective blood was basically the same, which was 210 μg / L; each volunteer corresponded to and only corresponded to a verification experiment of one example; for the above-mentioned volunteers, a silicone gel non-woven fabric acupoint patch with a medicine pit inner diameter of 3 cm was used, and 10 g of the dressing corresponding to each example was filled in the medicine pit, and it was applied to the Tiantu acupoint for 8 h, repeated once a day. After 90 days, the hospital was entrusted to collect the venous blood of each volunteer, and the human thyroglobulin (TG) detection kit of XinYu Biology was used to measure and calculate the thyroglobulin content of each volunteer according to the ELISA method.

[0070] The results of the experiment are shown in Table 1. The unit of thyroglobulin content is μg / L, and the integer significant figures are retained.

[0071] Table 1: Test results of thyroglobulin content of volunteers corresponding to each example:

[0072]

[0073] As can be seen from the data in Table 1, compared with other examples, the anti-tumor composite dressing prepared by the solution of the anti-tumor composite dressing and its preparation method in Example 1 of the present invention, especially, has a thyroglobulin content closer to the normal value under the same dressing dosage and usage method; that is, the anti-tumor composite dressing obtained by the solution of the present invention can delay and even relieve the symptoms of thyroid tumors by dressing, and ultimately achieve the effect of remaining benign without surgery for a relatively long period (90 days).

[0074] It should be noted that the above process parameters and effects have a non-linear correlation, and the cooperation conditions with other components and processes of the present invention should be considered. The above are only the embodiments of the present invention and are not used to limit the present invention; for those skilled in the art, the present invention can have various changes and modifications; any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the scope of the claims of the present invention.

Claims

1. A preparation method of a composite dressing for anti-thyroid tumors, characterized in that, The preparation method of the composite dressing for anti-thyroid tumor comprises the following steps: Step 1: Take oyster with a mass fraction of 22 - 29%, scrophularia with a mass fraction of 20 - 27%, turtle shell with a mass fraction of 11 - 16%, scorpion with a mass fraction of 8 - 12%, cobra with a mass fraction of 6 - 10%, toad venom with a mass fraction of 3 - 5%, and pure water to make up the remaining mass fraction. Chop the above medicinal materials, pass through a 20-mesh sieve, add 85% ethanol which is 10 times the total mass of the above medicinal materials and water, immerse at 63°C for 40 h. Pour the solid-liquid mixture into an ultrafine grinder, with a crushing temperature of 10°C and a main shaft rotation speed of 960 r / min. After discharging, filter through a 200-mesh sieve to obtain a crude filtered extract. Add 0.2 times the mass of pure water to the crude filtered extract, and then perform vacuum distillation in a rotary evaporator at 38°C and a pressure of 120 mbar until the mass is 0.1 times that before distillation. Collect the remaining liquid to obtain a traditional Chinese medicine extract; Step 2: Melt beeswax at 65°C for standby. Rapidly stir the traditional Chinese medicine extract and beeswax with a mass of 0.05 times the mass of the traditional Chinese medicine extract at 50°C until emulsified and mixed to obtain the composite dressing for anti-thyroid tumor.

2. The preparation method of the composite dressing for anti-thyroid tumor according to claim 1, characterized in that, The mass fraction of the oyster is 26%.

3. The preparation method of the composite dressing for anti-thyroid tumor according to claim 1, characterized in that, The mass fraction of the scrophularia is 25%.

4. The preparation method of the composite dressing for anti-thyroid tumor according to claim 1, wherein, The mass fraction of the turtle shell is 14%.

5. The preparation method of the composite dressing for anti-thyroid tumor according to claim 1, characterized in that, The mass fraction of the scorpion is 10%.

6. The preparation method of the composite dressing for anti-thyroid tumor according to claim 1, characterized in that, The mass fraction of the cobra is 8%.

7. The preparation method of the anti-thyroid tumor composite dressing according to claim 1, wherein The mass fraction of the toad venom is 4%.

8. An anti-thyroid tumor composite dressing prepared by the method for preparing an anti-thyroid tumor composite dressing according to any one of claims 1 to 7, characterized in that, The composite dressing for anti-thyroid tumor comprises: the traditional Chinese medicine extract and beeswax with a mass of 0.05 times the mass of the traditional Chinese medicine extract.

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