Antibodies or antigen-binding fragments thereof against np protein of sftsv and use thereof
By developing antibodies or antigen-binding fragments that specifically bind to the new Bunyavirus NP protein, a highly sensitive immunoassay kit was prepared, solving the problems of complexity and equipment dependence in existing detection methods, and realizing rapid and convenient SFTSV detection.
CN118852419BActive Publication Date: 2026-06-02SURE BIOTECH (HANGZHOU) LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SURE BIOTECH (HANGZHOU) LTD
- Filing Date
- 2024-07-31
- Publication Date
- 2026-06-02
AI Technical Summary
Technical Problem
Existing SFTSV testing methods are complex to operate, require specialized equipment and personnel, and lack rapid testing methods suitable for point-of-care testing and large-scale population screening.
Method used
Antibodies or antigen-binding fragments of the novel Bunyavirus NP protein have been developed. Highly sensitive and specific immunoassay kits have been prepared using the double-antibody sandwich principle, which are suitable for rapid detection of SFTSV.
Benefits of technology
It enables screening for early infection with the novel Bunyavirus and provides clinical auxiliary diagnosis for later prognosis, offering a rapid and convenient testing method suitable for point-of-care testing and large-scale population screening.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN118852419B_ABST
Abstract
The application provides an antibody or antigen-binding fragment thereof against NP protein of SFTSV and application thereof, and relates to the technical field of biotechnology.The antibody or antigen-binding fragment thereof contains a complementarity determining region of a heavy chain variable region and a complementarity determining region of a light chain variable region, the complementarity determining region of the heavy chain variable region includes amino acid sequences identical to HCDR1, HCDR2 and HCDR3 of the heavy chain variable region shown in SEQ ID NO.1 or 3; and the complementarity determining region of the light chain variable region includes amino acid sequences identical to LCDR1, LCDR2 and LCDR3 of the light chain variable region shown in SEQ ID NO.2 or 4.The NP protein of SFTSV is detected by an immunodetection product using the antibody or antigen-binding fragment thereof, and the detection has good sensitivity and specificity.
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