A traditional Chinese medicine preparation for treating tachycardia

Abstract

The application discloses a traditional Chinese medicine preparation for treating tachycardia, which is prepared from the following raw medicinal materials: cassia twig 10-20 g, white atractylodes 10-20 g, radix codonopsis 15-25 g, prepared rehmannia 15-25 g, raw oyster shell 25-35 g, raw concha mallei 25-35 g, sophora flavescens 10-20 g, schisandra chinensis 10-20 g, gancao 15-25 g, ophiopogon japonicus 10-20 g, and turtle shell 10-20 g. The traditional Chinese medicine preparation for treating tachycardia is orally taken in a daily dose, and is taken twice a day, in the morning and in the evening, half an hour after meals, and is continuously taken for 4 weeks as a treatment course. The traditional Chinese medicine preparation for treating tachycardia can obviously improve symptoms such as palpitation, short breath, five heart heat, hot flashes, insomnia, dreaminess, anxiety and the like, has a remarkable curative effect, is safe, is cheap and simple, and has a high clinical promotion value.

Description

TECHNICAL FIELD

[0001] The present application relates to a kind of traditional Chinese medicine preparation for treating tachycardia, belong to traditional Chinese medicine preparation technical field. BACKGROUND

[0002] Tachycardia has obvious clinical symptoms, and patients have strong physical discomfort. The common clinical pathological tachycardia is divided into sinus tachycardia, supraventricular tachycardia, rapid atrial fibrillation, ventricular tachycardia and so on. Whether it is paroxysmal or continuous, it is easy to cause serious complications such as myocardial disease and heart failure. If it is combined with hemodynamic instability, the mortality rate of tachycardia is very high, which is an important cause of sudden cardiac death. In clinical practice, some patients have obvious discomfort, but no clear arrhythmia is captured, mostly middle-aged and elderly women, which is called functional tachycardia. Supraventricular tachycardia is one of the most common arrhythmias. Supraventricular tachycardia refers to a group of rapid arrhythmias in which the ectopic excitation forms above the His bifurcation or the reentry loop. In clinical practice, supraventricular tachycardia includes atrial tachycardia (atrial tachycardia), atrial flutter (atrial flutter), sinoatrial reentrant tachycardia, atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT). Atrial tachycardia and atrial flutter are mostly seen in patients with organic heart and lung diseases, such as chronic obstructive pulmonary disease, valvular heart disease, etc. They can occur after cardiac and thoracic surgery, and also in patients without clear organic heart disease. AVNRT and AVRT are mostly seen in patients without organic heart disease. The onset and termination of tachycardia are often sudden, and the frequency is less than 200 times per minute in young patients without organic heart disease, and the duration is relatively short. Most of them only have sudden palpitations, sometimes accompanied by fear, anxiety and polyuria. In patients with organic heart disease, the frequency is more than 200 times per minute, and the duration is relatively long, which can cause insufficient blood supply to organs such as heart and brain, leading to decreased blood pressure, dizziness, blackouts, angina pectoris, heart failure and other symptoms.

[0003] In western medicine, the development of antiarrhythmic drugs, radiofrequency ablation, implantation of implantable cardioverter-defibrillator (ICD) is rapid, but there are still patients with functional lesions, patients with poor drug effect, patients with radiofrequency that is difficult to completely ablate, and patients with ICD frequent discharge. The discomfort of patients is severe, and the body, psychology and economy of patients suffer great blows.

[0004] There is no exact record of this disease in the books of traditional Chinese medicine, but the onset characteristics of "palpitation" and "dizziness" are similar to this disease, so it can be used as a basis. Therefore, further research is needed to find an exact traditional Chinese medicine compound preparation to meet the needs of domestic and foreign markets. SUMMARY

[0005] In view of the above prior art, the present application provides a traditional Chinese medicine preparation for treating tachycardia.

[0006] The application is realized by the following technical scheme:

[0007] A traditional Chinese medicine preparation for treating tachycardia is prepared from the following raw materials: cassia 10-20 g, atractylodes 10-20 g, radix codonopsis 15-25 g, prepared rehmannia 15-25 g, raw oyster shell 25-35 g, raw conch 25-35 g, sophora 10-20 g, schisandra 10-20 g, sweet pine 15-25 g, ophiopogon 10-20 g, and turtle shell 10-20 g.

[0008] Preferably, the traditional Chinese medicine preparation for treating tachycardia is prepared from the following raw materials: cassia 15 g, atractylodes 15 g, radix codonopsis 20 g, prepared rehmannia 20 g, raw oyster shell 30 g, raw conch 30 g, sophora 15 g, schisandra 15 g, sweet pine 20 g, ophiopogon 15 g, and turtle shell 15 g.

[0009] The preparation method of the traditional Chinese medicine preparation for treating tachycardia comprises the following steps:

[0010] (1) Mix raw oyster shell, raw conch, and turtle shell, and soak them in water for 20-40 minutes for standby; mix cassia, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine, and ophiopogon, and soak them in water for 20-40 minutes for standby;

[0011] (2) Cook raw oyster shell, raw conch, and turtle shell for 20-30 minutes (raw oyster shell, raw conch, and turtle shell are hard medicinal materials such as minerals and shells, so they are cooked first);

[0012] (3) Add cassia, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine, and ophiopogon, and cook for 30-50 minutes to pour out the medicinal soup, which is the first decoction; add water to the medicinal residue, and cook for 30-50 minutes to pour out the medicinal soup, which is the second decoction; mix the two decoctions together to obtain the traditional Chinese medicine preparation for treating tachycardia.

[0013] Further, in step (1), the soaking time is 30 minutes.

[0014] Further, in step (2), the cooking time is 25 minutes.

[0015] Further, in step (3), the cooking time is 40 minutes.

[0016] The traditional Chinese medicine preparation for treating tachycardia of the application has the following treatment idea: the occurrence of the disease is mainly because of heart yin deficiency, "the heart is the main part of the human body, and the blood is the nourishment of the heart. If the heart blood is deficient, the spirit will not be stable, which is the beginning of palpitation", the heart yin includes the body fluid, blood and yin essence of the heart, and the heart blood also belongs to part of the heart yin. The functions of the heart in governing blood vessels and spirit must rely on the nourishment of the heart yin and the filling of the heart blood. The causes mainly include: first, overthinking and overwork, emotional internal injury, and hidden consumption of heart yin, that is, "if a person cannot concentrate on things, and thinks more, it is caused by overthinking and overwork, heart blood deficiency and damage", second, deficiency of yin in nature, or long-term illness and body decay, or heat disease damaging yin, or loss of treatment, misdiagnosis, overeating of hot medicine, consumption of yin, resulting in heart yin deficiency; third, old age and body decay, "the Great Discussion on Yin and Yang Correspondence and Shape" says, "at the age of 40, the yin energy is half, and the living is declining", which indicates that after middle age, the body yin energy begins to be scarce, the functions of viscera are declining, and the heart yin is deficient; fourth, deficiency of liver and kidney, and long-term damage to heart yin. The heart yin is consumed, and the heart is not nourished; at the same time, the deficiency of yin can also lead to deficiency of qi, so "the Yin Deficiency is No Qi"; the yin and yang are interdependent, and the long-term yin deficiency can also lead to yang deficiency; long-term yin deficiency, yin does not control yang, yang qi is hyperactive, internal fire is generated, liquid is refined into phlegm, and phlegm is accumulated in the heart and vessels; the internal generation of phlegm and blood stasis can block the blood circulation, and the phlegm and blood stasis can also block the qi, leading to qi stagnation; qi stagnation can promote the generation of phlegm and blood stasis, and the three are interdependent, making the deficiency more deficient, and the disease more serious. On the basis of the causes and mechanisms of the disease, the application develops the Yayin Anshen Dingji Decoction, which combines Rehmannia glutinosa to nourish yin and blood, Ophiopogon japonicus to nourish yin and clear the heart, and Carapax Trionycis to nourish yin and suppress yang, which can supplement heart yin and nourish heart blood, and combine Cinnamomum cassia to warm and supplement heart yang, to help the generation of heart yin, and combine Cinnamomum cassia with Schisandra chinensis to suppress yang and control hyperactive yang, so that the dragon returns to the sea, and the gas is self-contracted; add Codonopsis pilosula to supplement qi and nourish blood, qi, blood, yin and yang are all supplemented. The combination of raw oyster shell and raw dragon bone can calm the yang and calm the spirit, and can also play a role in stopping sweat, preventing heart yin from being consumed.

[0017] The medicine compatibility of the present application is unique, which not only focuses on the synergistic effect among the medicines, but also avoids the antagonistic effect among the medicines. For example, the compatibility of cassia twig and licorice can enhance the effect of warming and tonifying heart yang; the compatibility of raw oyster shell and raw conch can enhance the effect of heavy tranquilization and tranquilization of the mind; the compatibility of kuh-seng and ophiopogon can clear heat and nourish yin without damaging the normal body, etc. This unique medicine compatibility mode is helpful to improve the overall curative effect. The raw oyster shell is selected in the present application because the raw oyster shell has unique medicinal value and effect in the theory of traditional Chinese medicine. It can not only heavy tranquilize the mind, hide yang and tonify yin, but also is particularly suitable for the patients with rapid heart rate accompanied by palpitation, insomnia and other symptoms. Moreover, the rich mineral and trace elements of the raw oyster shell also have certain regulating effect on the heart function. More importantly, the raw oyster shell has better compatibility effect with other medicines in the present application. For example, the compatibility of the raw oyster shell and the raw conch can enhance the effect of heavy tranquilization and tranquilization of the mind, which has significant effect on relieving the nervous emotion and anxiety state of the patients with rapid heart rate; the compatibility of the raw oyster shell and kuh-seng can clear heat and dry dampness, and regulate the damp-heat state in the body, thereby indirectly improving the heart function. Therefore, considering the unique effect of the raw oyster shell and the compatibility effect of the raw oyster shell in the present application, the raw oyster shell is selected as one of the key raw medicines.

[0018] The traditional Chinese medicine preparation for treating rapid heart rate of the present application is orally taken (the medicine is absorbed through the gastrointestinal mucosa to play a therapeutic role) in a daily dose (the amount of each raw medicine as recorded above is the amount of one dose), which is taken twice a day, half an hour after breakfast and dinner, and is continuously taken for 4 weeks as one course of treatment.

[0019] The improvement of the symptoms of the patients, such as palpitation and shortness of breath, five heart heat, hot flashes, insomnia, dreaminess, anxiety and unease, etc. after the treatment of the traditional Chinese medicine preparation for treating rapid heart rate of the present application is obviously better than that of the control group (oral metoprolol), which has statistical significance (P<0.05). The improvement in the TCM syndrome score is better than that of the control group, which has statistical significance (P<0.05). The traditional Chinese medicine preparation for treating rapid heart rate of the present application has significant curative effect, good safety, low price and simple medicine, and has high clinical popularization value.

[0020] The various terms and phrases used in the present application have the general meanings known to those skilled in the art. DETAILED DESCRIPTION

[0021] The present application will be further described in conjunction with the examples. However, the scope of the present application is not limited to the following examples. Those skilled in the art can understand that various changes and modifications can be made to the present application without departing from the spirit and scope of the present application.

[0022] The instruments, reagents, materials involved in the following examples, if no special instructions, are conventional instruments, reagents, materials already existing in the prior art, which can be obtained through regular commercial channels. The experimental methods, detection methods, etc. involved in the following examples, if no special instructions, are conventional experimental methods, detection methods already existing in the prior art.

[0023] Example 1 Preparation of traditional Chinese medicine preparation for treating tachycardia

[0024] The composition is: cassia twig 15 g, atractylodes 15 g, radix codonopsis 20 g, radix rehmanniae preparata 20 g, raw oyster shell 30 g, raw conch 30 g, sophora flavescens 15 g, schisandra chinensis 15 g, sweet pine 20 g, ophiopogon 15 g, turtle shell 15 g. Each raw material medicine selects the corresponding traditional Chinese medicine decoction piece.

[0025] The preparation method is as follows:

[0026] (1) Mix raw oyster shell, raw conch and turtle shell, soak in water for 30 minutes, and prepare for use; Mix cassia twig, atractylodes, radix codonopsis, radix rehmanniae preparata, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon, soak in water for 30 minutes, and prepare for use;

[0027] (2) Raw oyster shell, raw conch and turtle shell are decocted for 25 minutes;

[0028] (3) Add cassia twig, atractylodes, radix codonopsis, radix rehmanniae preparata, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon, decoct for 40 minutes, pour out the decoction, which is the first decoction; Add water to the residue, decoct for 40 minutes again, pour out the decoction, which is the second decoction; Mix the two decoctions together, and the traditional Chinese medicine preparation for treating tachycardia is obtained.

[0029] Clinical research data

[0030] The research group of the inventors of the present application showed in the previous study that the present composition can significantly improve the symptoms of tachycardia in patients, can significantly improve the discomfort symptoms and TCM syndrome score of patients, and has good safety, fully embodies the advantages of TCM treatment of tachycardia, and at the same time, the preparation method is summarized from the clinical experience of the inventors for many years, which provides a safe and effective guarantee for the clinical popularization and application.

[0031] 1. Clinical data

[0032] 1.1 Diagnostic criteria

[0033] 1.1.1 Western medicine diagnostic criteria

[0034] The western medicine diagnostic criteria of this study, "Diagnosis and Treatment of Supraventricular Tachycardia and Treatment of Chinese Expert Consensus (2021)" and "Supraventricular Tachycardia Basic Diagnosis and Treatment Guidelines (2019)", are as follows:

[0035] (1) Heart rate 150-250 times / min, rhythm regular.

[0036] (2) QRS wave form and time limit are normal, but there is intraventricular differential conduction or original bundle branch block, QRS wave form is abnormal.

[0037] (3) Some patients can see retrograde P' wave, often at the end of QRS wave (pseudo-s wave in lead II, III, aVF, pseudo-r' wave in lead aVR, V1) or ST segment, T wave ascending branch, QRS wave and P' wave are fixed.

[0038] (4) The onset is sudden, often triggered by a premature atrial beat, and the PR interval of its downward transmission is significantly prolonged, followed by supraventricular attack.

[0039] 1.1.2 Diagnosis and quantitative standard of traditional Chinese medicine

[0040] All patients diagnosed as heart yin deficiency type according to the Diagnosis and Curative Effect Standard of TCM. The main symptoms are subjective heart palpitations, or excessive jumping, or jumping and stopping. It is paroxysmal or continuous, nervous, and the heart is not at ease. The secondary symptoms are palpitation, thinking and mental stress, hot in the heart, less sleep and more dreams, dizziness, tinnitus, dry mouth, hot cheeks. Red tongue, thin yellow fur, thin and stringy pulse. Three items of secondary symptoms can be diagnosed with two main symptoms.

[0041] 1.2 Inclusion criteria

[0042] (1) In line with the above diagnostic criteria;

[0043] (2) Age 18-60 years old;

[0044] (3) No use of hormone or mental drugs, or stop using in the past few months, and promise not to take other related drugs during treatment;

[0045] (4) No drug dependence;

[0046] (5) No serious suicidal tendency;

[0047] (6) Can be followed up;

[0048] (7) Volunteers participating in this study.

[0049] 1.3 Exclusion criteria

[0050] (1) Allergic body or allergic to the drug;

[0051] (2) Patients with cardiovascular and cerebrovascular diseases or other organic diseases;

[0052] (3) Patients with other nervous, mental and endocrine diseases;

[0053] (4) Patients with drug or alcohol dependence within 3 months or who have participated in other research projects or taken other tranquilizers.

[0054] 1.4 Discontinuation, withdrawal criteria

[0055] (1) Patients who do not use drugs as required during the experiment;

[0056] (2) Patients who have serious adverse reactions or changes in condition;

[0057] (3) Patients who voluntarily withdraw from the experiment;

[0058] (4) Patients who voluntarily take related drugs during treatment. Patients with allergic constitution or allergic to the drug.

[0059] 1.4 Exclusion criteria

[0060] (1) Patients who are found to be not in line with the inclusion criteria or in line with the exclusion criteria after inclusion;

[0061] (2) Patients who are found to have poor compliance and cannot strictly follow the treatment plan after inclusion;

[0062] (3) Patients who randomly use prohibited drugs during treatment after inclusion.

[0063] 1.5 Dropout criteria

[0064] (1) Poor compliance or combination of drugs outside the specified range, affecting the judgment of efficacy and safety;

[0065] (2) Patients who have allergic reactions or serious adverse events and cannot continue treatment;

[0066] (3) Patients who cannot continue the clinical trial due to various reasons, withdraw or discontinue the trial.

[0067] 1.6 General information

[0068] The included patients were patients who visited the outpatient department from January 2019 to January 2022, aged 18-60 years, diagnosed with tachycardia, a total of 60 cases. Randomized controlled principle is divided into oral traditional Chinese medicine preparation Yangyin Anshen Dingji Decoction group, western medicine group, each 30 cases. There is no significant difference in age between each group, with baseline consistency (P>0.05).

[0069] 2. Methods

[0070] 2.1 Treatment method

[0071] Treatment group: Yangyin Anshen Dingji Decoction (i.e. the traditional Chinese medicine preparation of the present application, prepared in Example 1), 1 dose per day, half an hour after breakfast and dinner. Take continuously for 4 weeks.

[0072] Control group: oral metoprolol tartrate (Astra Pharmaceuticals Limited, GMP H32025391, specification 50 mg, 20 tablets), once a day, 1 tablet each time, before breakfast, continuous use for 4 weeks.

[0073] 2.2 Observation index

[0074] 2.2.1 General information observation

[0075] The patient's age, disease progression, disease changes during treatment, and adverse reactions during treatment were observed and recorded.

[0076] 2.2.2 Treatment effect evaluation (recorded once before and after treatment)

[0077] Success rate and time of rhythm control, TCM syndrome score.

[0078] 3. Safety evaluation

[0079] Patients should pay attention to self-monitoring of blood pressure, heart rate and other vital signs during treatment. Blood, urine, stool routine, and liver and kidney function tests were performed before and after treatment.

[0080] 2.3 Efficacy evaluation criteria

[0081] 2.3.1 Western medical efficacy criteria

[0082] Dynamic electrocardiogram changes: significant effect: average heart rate decreased to 60-100 times / min; effective: average heart rate decreased by 20% or more than before treatment; ineffective: no change in average heart rate; aggravation: average heart rate increased by 20% or more than before treatment.

[0083] 2.3.2 TCM efficacy criteria

[0084] TCM syndrome score was modified according to the relevant contents of "Clinical Disease Diagnosis Basis Cure and Improvement Criteria" and "Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine (Trial)", evaluated by Nimodipine method, and the efficacy index (n) = [(pre-treatment score - post-treatment score) / pre-treatment score] x 100%. Cure: n≥95%; significant effect: 70%≤n<95%; improvement: 30%≤n<70%; ineffective: n<30%.

[0085] 2.3.3 Safety evaluation criteria

[0086] Grade 1: safe, no adverse reactions. Grade 2: relatively safe, does not affect continued administration and does not require special treatment. Grade 3: safety issues, moderate adverse reactions, can continue administration after treatment. Grade 4: serious adverse reactions, discontinue the trial.

[0087] 2.3.4 Adverse event severity judgment criteria

[0088] Mild: Tolerable, does not affect treatment and recovery, no special treatment required. Moderate: Unbearable, requires immediate discontinuation of medication or special treatment, affects recovery. Severe: Life-threatening, requires immediate discontinuation of medication or emergency treatment.

[0089] 2.4 Medical Ethics Control

[0090] When patients are enrolled in the clinical study, researchers will inform them or their families in detail of the following: the patient's Chinese and Western medicine diagnoses, the Chinese medicine syndrome differentiation, the further treatment plan, the expected treatment goals, and possible adverse reactions. The patient's address and telephone number will be recorded in detail for clinical follow-up. If the patient's symptoms worsen or discomfort occurs after treatment, they should contact the researchers immediately by phone to discontinue treatment, receive symptomatic treatment, and withdraw from the study. Participation and withdrawal are entirely voluntary.

[0091] 2.5 Statistical Methods

[0092] Statistical analysis was performed on all data using SPSS 26.0 software. Generally, two-tailed tests were used for statistical analysis, and a p-value < 0.05 was considered statistically significant. Chi-square tests were used for count data. 2 For statistical analysis, data are described using frequency, percentage, or proportion. Ordinal data are described using the rank-sum test, using proportion or rate. For continuous data, a normality analysis is first performed using the KS test. Continuous data that conforms to or approximately conforms to a normal distribution are expressed as mean ± standard deviation (X(—) ± S). Continuous data that does not conform to a normal distribution are expressed as the median (interquartiles), i.e., M(Q1, Q3). Data that conforms to normality and homogeneity of variance are tested using the t-test; otherwise, the rank-sum test is used.

[0093] 3. Results

[0094] 3.1 Comparison of the therapeutic effects of dynamic electrocardiogram between the two groups

[0095] There was no significant difference in dynamic electrocardiogram between the two groups before treatment. After treatment, both groups showed improvement compared to before treatment. However, the improvement in the treatment group was significantly better than that in the control group after treatment (P<0.05), as shown in Table 1.

[0096] Table 1 Comparison of therapeutic effects between the two groups of Holter monitoring

[0097]

[0098] 3.2 Comparison of TCM symptom scores before and after treatment

[0099] There was no significant difference in TCM syndrome scores between the two groups before treatment. After treatment, both groups showed improvement compared to before treatment. However, the improvement in the treatment group was significantly better than that in the control group after treatment (P<0.05), as shown in Table 2.

[0100] Table 2 Comparison of TCM syndrome score in two groups (X(-)±S)

[0101]

[0102] Note: * P<0.05 for comparison between groups after treatment.

[0103] 3.3 Adverse reaction occurrence

[0104] The liver and kidney functions of patients in each group were normal before and after treatment, and no adverse reactions occurred in each group.

[0105] 4. Discussion

[0106] The clinical research results show that the improvement of symptoms such as palpitation, shortness of breath, five heat, night sweat, insomnia, dreaminess, anxiety and restlessness of patients in the traditional Chinese medicine treatment group after treatment is obviously better than that of the control group (oral metoprolol), which has statistical significance (P<0.05). The improvement in TCM syndrome score is better than that of the control group, which has statistical significance (P<0.05). The traditional Chinese medicine preparation for treating tachycardia of the present application has remarkable curative effect, good safety, low price and simple medicine, and has high clinical popularization value.

[0107] 5. Conclusion

[0108] The clinical application effect of the yin-nourishing and heart-calming tachycardia-relieving prescription of the present application is obviously better than that of the commonly used metoprolol tartrate in clinic, and has good safety, which provides a guarantee for its clinical popularization.

[0109] Example 2 Preparation of the traditional Chinese medicine preparation for treating tachycardia

[0110] The group formula is: cassia 10 g, atractylodes 20 g, radix codonopsis 15 g, prepared rehmannia 25 g, raw oyster shell 25 g, raw oyster 35 g, sophora 10 g, schisandra 20 g, sweet pine 15 g, ophiopogon 20 g, turtle shell 10 g. Each raw material medicine selects the corresponding traditional Chinese medicine decoction piece.

[0111] The preparation method is as follows:

[0112] (1) Mix raw oyster shell, raw oyster and turtle shell, soak in water for 30 minutes, and prepare for use; Mix cassia, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine and ophiopogon, soak in water for 30 minutes, and prepare for use;

[0113] (2) Cook raw oyster shell, raw oyster and turtle shell for 20 minutes;

[0114] (3) Add cassia, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine and ophiopogon, and cook for 50 minutes. Pour out the medicine soup, which is the first decoction. Add water to the medicine residue, and decoct for 50 minutes again. Pour out the medicine soup, which is the second decoction. Mix the two decoctions together, and the traditional Chinese medicine preparation for treating tachycardia is obtained.

[0115] Example 3 Preparation of a Chinese medicine preparation for treating tachycardia

[0116] The prescription is: cassia twig 20 g, atractylodes 10 g, radix codonopsis 25 g, prepared rehmannia 15 g, raw oyster shell 35 g, raw concha 25 g, sophora 20 g, schisandra 10 g, sweet pine 25 g, ophiopogon 10 g, turtle shell 20 g. Each raw material medicine selects the corresponding traditional Chinese medicine decoction piece.

[0117] The preparation method is as follows:

[0118] (1) Mix raw oyster shell, raw concha and turtle shell, soak in water for 30 minutes, and prepare for use; Mix cassia twig, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine and ophiopogon, soak in water for 30 minutes, and prepare for use;

[0119] (2) Cook raw oyster shell, raw concha and turtle shell for 30 minutes;

[0120] (3) Add cassia twig, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine and ophiopogon, and decoct for 30 minutes. Pour out the medicinal soup, which is the first decoction. Add water to the residue, decoct for another 30 minutes, and pour out the medicinal soup, which is the second decoction. Mix the two decoctions together, and it is obtained.

[0121] Example 4 Preparation of a Chinese medicine preparation for treating tachycardia

[0122] The prescription is: cassia twig 13 g, atractylodes 17 g, radix codonopsis 18 g, prepared rehmannia 22 g, raw oyster shell 28 g, raw concha 32 g, sophora 13 g, schisandra 17 g, sweet pine 18 g, ophiopogon 17 g, turtle shell 13 g.

[0123] The preparation method is as follows:

[0124] (1) Mix raw oyster shell, raw concha and turtle shell, soak in water for 20 minutes, and prepare for use; Mix cassia twig, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine and ophiopogon, soak in water for 20 minutes, and prepare for use;

[0125] (2) Cook raw oyster shell, raw concha and turtle shell for 25 minutes;

[0126] (3) Add cassia twig, atractylodes, radix codonopsis, prepared rehmannia, sophora, schisandra, sweet pine and ophiopogon, and decoct for 40 minutes. Pour out the medicinal soup, which is the first decoction. Add water to the residue, decoct for another 40 minutes, and pour out the medicinal soup, which is the second decoction. Mix the two decoctions together, and it is obtained.

[0127] Example 5 Preparation of a Chinese medicine preparation for treating tachycardia

[0128] Ingredients: cassia twig 18 g, atractylodes 13 g, radix codonopsis 22 g, prepared rehmannia 18 g, raw oyster shell 32 g, raw concha mallei 28 g, sophora flavescens 18 g, schisandra chinensis 12 g, sweet pine 22 g, ophiopogon 12 g, turtle shell 18 g.

[0129] The preparation method is as follows:

[0130] (1) Mix raw oyster shell, raw concha mallei and turtle shell, soak in water for 40 minutes, and prepare for use. Mix cassia twig, atractylodes, radix codonopsis, prepared rehmannia, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon, soak in water for 40 minutes, and prepare for use;

[0131] (2) Boil raw oyster shell, raw concha mallei and turtle shell for 25 minutes;

[0132] (3) Add cassia twig, atractylodes, radix codonopsis, prepared rehmannia, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon, and boil for 40 minutes. Pour out the decoction, which is the first decoction. Add water to the residue, and boil for another 40 minutes. Pour out the decoction, which is the second decoction. Mix the two decoctions together, and you get the final product.

[0133] The above examples are provided to those skilled in the art to fully disclose and describe how to implement and use the claimed embodiments, rather than to limit the scope of the disclosure disclosed herein. Modifications obvious to those skilled in the art will be within the scope of the appended claims.

Claims

1. A traditional Chinese medicine preparation for treating tachycardia, characterized in that, Is made of the following raw drugs: cassia twig 15 g, white atractylodes 15 g, radix codonopsis 20 g, prepared rehmannia 20 g, raw oyster shell 30 g, raw concha 30 g, sophora flavescens 15 g, schisandra chinensis 15 g, sweet pine 20 g, ophiopogon 15 g, turtle shell 15 g; each raw drug selects corresponding traditional Chinese medicine decoction piece; Is prepared by the following method: (1) raw oyster shell, raw concha and turtle shell are mixed, soaked in water for 30 minutes, and prepared; cassia twig, white atractylodes, radix codonopsis, prepared rehmannia, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon are mixed, soaked in water for 30 minutes, and prepared; (2) raw oyster shell, raw concha and turtle shell are decocted for 25 minutes; (3) cassia twig, white atractylodes, radix codonopsis, prepared rehmannia, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon are added, decocted for 40 minutes, and the medicine soup is poured out, which is the first decoction; the medicine residue is added with water, decocted for 40 minutes again, and the medicine soup is poured out, which is the second decoction; the two decoctions are mixed together, and the medicine soup is obtained.

2. The preparation method of the traditional Chinese medicine preparation for treating tachycardia according to claim 1, characterized in that, The steps are as follows: (1) raw oyster shell, raw concha and turtle shell are mixed, soaked in water for 30 minutes, and prepared; cassia twig, white atractylodes, radix codonopsis, prepared rehmannia, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon are mixed, soaked in water for 30 minutes, and prepared; (2) raw oyster shell, raw concha and turtle shell are decocted for 25 minutes; (3) cassia twig, white atractylodes, radix codonopsis, prepared rehmannia, sophora flavescens, schisandra chinensis, sweet pine and ophiopogon are added, decocted for 40 minutes, and the medicine soup is poured out, which is the first decoction; the medicine residue is added with water, decocted for 40 minutes again, and the medicine soup is poured out, which is the second decoction; the two decoctions are mixed together, and the medicine soup is obtained.

Images