An insecticide composition containing cybenzoxasulfyl and its application

Abstract

The present invention belongs to the field of pesticide insecticide technology and discloses an insecticidal composition containing cybenzoxasulfyl and its use. The active ingredients of the insecticidal composition include active ingredient A and active ingredient B, wherein active ingredient A is cybenzoxasulfyl and active ingredient B is any one of spidoxamat, spiropidion, or spiromesifen. The mass ratio of active ingredient A to active ingredient B is 45:1 to 1:30. The insecticidal composition of the present invention has excellent control effects on piercing-sucking pests and can be used for the integrated control of agricultural, horticultural, and forestry pests.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticide killing and discloses an insecticidal composition containing cybenzoxasulfyl and application thereof. Background Art

[0002] Spidoxamat is a spirocyclic quaternary ketoate acaricide. Its chemical name is: 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4 8 .2 5 Tetradec-11-en-10-one; CAS registration number: 907187-07-9. The structural formula is as follows:

[0003]

[0004] Spiropidion, chemically known as 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-1-methyl-2-oxyylidene-1,8-diazaspiro[4.5]dec-3-en-4-yl carbonate, belongs to the heterocyclic quaternary acid class of insecticides. This compound exhibits strong insecticidal activity against common fruit and vegetable pests such as spider mites, scale insects, rust mites, and aphids. Its structural formula is as follows:

[0005]

[0006] Spiromesifen is a spirocyclic tetraconjugate insecticide and acaricide developed by Bayer. It is primarily used to control whiteflies and spider mites on cotton, vegetables, and ornamental plants. Its mechanism of action is to interfere with the biosynthesis of lipid bodies, thereby affecting the development of the pests. It is particularly active against the larval stage. It can also produce an ovarian duct closure effect, reducing the pest's reproductive capacity and the number of eggs it lays. Its structural formula is as follows:

[0007]

[0008] Piercing-sucking pests such as aphids, whiteflies, and scale insects can damage high-value fruit and vegetable crops like tomatoes, oranges, and melons, as well as important arable crops like soybeans and cotton. These pests can also carry a variety of viruses, further exacerbating the damage to plants. Summary of the Invention

[0009] To address the aforementioned problems in the prior art, the present invention provides an insecticidal composition containing cybenzoxasulfyl and its use. This insecticidal composition effectively controls a variety of piercing-sucking pests, exhibiting synergistic effects within a certain ratio range. It is particularly effective against whiteflies, reducing pesticide use costs, reducing dosage, extending the duration of efficacy, and delaying the development of pesticide resistance.

[0010] To achieve the above object, the present invention adopts the following technical solution: an insecticidal composition containing cybenzoxasulfyl, wherein the active ingredients of the insecticidal composition include active ingredient A and active ingredient B, wherein the active ingredient A is cybenzoxasulfyl, and the active ingredient B is any one of spidoxamat, spiropidion, or spiromesifen, and the mass ratio of the active ingredient A to the active ingredient B is 45:1 to 1:30, or any value within the above numerical range;

[0011] Furthermore, the mass ratio of cybenzoxasulfyl to spidoxamat is 35:1 to 1:25, or any value within the above numerical range; the mass ratio of cybenzoxasulfyl to spiropidion is 30:1 to 1:24, or any value within the above numerical range; the mass ratio of cybenzoxasulfyl to spiromesifen is 20:1 to 1:28, or any value within the above numerical range;

[0012] Furthermore, the mass ratio of cybenzoxasulfyl to spidoxamat is 35:1, 25:1, 15:1, 5:1, 3:2, 1:5, 1:10, 1:15, 1:25, or any value therebetween; the mass ratio of cybenzoxasulfyl to spiropidion is 30:1, 25:1, 15:1, 8:1, 3:1, 1:2, 1:5, 1:12, 1:24, or any value therebetween; the mass ratio of cybenzoxasulfyl to spiromesifen is 20:1, 8:1, 4:1, 1:1, 1:4, 1:8, 1:16, 1:28, or any value therebetween;

[0013] Furthermore, the mass ratio of cybenzoxasulfyl to spidoxamat is 25:1 to 1:15, or any value within the above numerical range; the mass ratio of cybenzoxasulfyl to spiropidion is 25:1 to 1:12, or any value within the above numerical range; the mass ratio of cybenzoxasulfyl to spiromesifen is 8:1 to 1:16, or any value within the above numerical range.

[0014] Furthermore, the mass ratio of cybenzoxasulfyl to spidoxamat is 25:1, 15:1, 5:1, 3:2, 1:5, 1:10, 1:15, or any value therebetween; the mass ratio of cybenzoxasulfyl to spiropidion is 25:1, 15:1, 8:1, 3:1, 1:2, 1:5, 1:12, or any value therebetween; the mass ratio of cybenzoxasulfyl to spiromesifen is 8:1, 4:1, 1:1, 1:4, 1:8, 1:16, or any value therebetween;

[0015] Furthermore, the mass ratio of cybenzoxasulfyl to spidoxamat is 15:1 to 1:10, or any value within the above numerical range; the mass ratio of cybenzoxasulfyl to spiropidion is 15:1 to 1:12, or any value within the above numerical range; the mass ratio of cybenzoxasulfyl to spiromesifen is 8:1 to 1:8, or any value within the above numerical range;

[0016] Furthermore, the mass ratio of cybenzoxasulfyl to spidoxamat is 15:1, 5:1, 3:2, 1:5, 1:10, or any value therebetween; the mass ratio of cybenzoxasulfyl to spiropidion is 15:1, 8:1, 3:1, 1:2, 1:5, 1:12, or any value therebetween; the mass ratio of cybenzoxasulfyl to spiromesifen is 8:1, 4:1, 1:1, 1:4, 1:8, or any value therebetween;

[0017] Furthermore, based on 100 wt% of the total weight of the insecticide composition, the mass ratio of the active ingredient A to the active ingredient B accounts for 1% to 70% of the total weight of the insecticide composition.

[0018] Furthermore, based on 100 wt% of the total weight of the insecticide composition, the mass ratio of the active ingredient A to the active ingredient B accounts for 2% to 60% of the total weight of the insecticide composition.

[0019] Furthermore, the insecticide composition may comprise, in addition to the active ingredient, a wetting agent, a dispersant, an emulsifier, a thickener, a disintegrant, an antifreeze agent, a defoaming agent, a solvent, a preservative, a stabilizer, a synergist or a carrier;

[0020] The wetting agent is selected from one or more of alkylbenzene sulfonate, alkylnaphthalene sulfonate, lignin sulfonate, sodium lauryl sulfate, sodium dioctyl sulfosuccinate, α-olefin sulfonate, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol ethoxylate, fatty alcohol ethoxylate, fatty alcohol polyoxyethylene ether sodium sulfate, silkworm feces, soapberry powder, soapberry powder, SOPA, detergent, emulsifier 2000 series and wetting penetrant F; and / or

[0021] The dispersant is selected from one or more of lignin sulfonate, alkylnaphthalene sulfonate formaldehyde condensate, naphthalene sulfonate, tristyrylphenol ethoxylate phosphate, fatty alcohol ethoxylate, alkylphenol polyoxyethylene ether, alkylphenol polyoxyethylene ether methyl ether condensate sulfate, fatty amine polyoxyethylene ether, glycerol fatty acid ester polyoxyethylene ether, polycarboxylates, polyacrylic acids, phosphates, EO-PO block copolymers and EO-PO graft copolymers; and / or

[0022] The emulsifier is selected from one or more of calcium dodecylbenzenesulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenylethylphenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrylphenol polyoxyethylene ether, castor oil polyoxyethylene ether and alkylphenol ether phosphate; and / or

[0023] The thickener is selected from one or more of xanthan gum, organobentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose and white carbon black; and / or

[0024] The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid and tartaric acid; and / or

[0025] The antifreeze agent is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons and inorganic salts; and / or

[0026] Defoaming agent selected from C 10 -C 20 Saturated fatty acid compounds, silicone oil, silicone compounds, C8-C 10 One or more of fatty alcohols; and / or

[0027] The solvent is selected from one or more of benzene, toluene, xylene, durene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, alkylene carbonate, diesel, solvent oil, vegetable oil, vegetable oil derivatives and water; and / or

[0028] The preservative is selected from one or more of propionic acid, sodium propionic acid, sorbic acid, sodium sorbic acid, potassium sorbic acid, benzoic acid, sodium benzoic acid, sodium p-hydroxybenzoic acid, methyl p-hydroxybenzoate, kasone and 1,2-benzisothiazolin-3-one; and / or

[0029] The stabilizer is selected from one or more of disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, white carbon black, talc, montmorillonite and starch; and / or

[0030] Synergists are selected from synergist, piperonyl butoxide; and / or

[0031] The carrier is selected from one or more of ammonium salts, ground natural minerals, ground artificial minerals, silicates, resins, waxes, solid fertilizers, water, organic solvents, mineral oils, vegetable oils and vegetable oil derivatives;

[0032] Furthermore, the insecticide composition is prepared into a preparation form; the preparation form is a solid preparation or a liquid preparation;

[0033] Furthermore, the solid preparation includes powders, granules, pellets, tablets, strips, wettable powders, oil-dispersible powders, emulsion powders, water-dispersible granules, emulsion granules, water-dispersible tablets, soluble powders, soluble tablets or soluble granules;

[0034] The liquid preparations include soluble solutions, soluble gels, oils, film-spreading oils, emulsifiable concentrates, latexes, dispersible solutions, ointments, aqueous emulsions, oil emulsions, microemulsions, lipid suspensions, microcapsule suspensions, oil suspensions, dispersible oil suspensions, suspoemulsions, microcapsule suspension-suspension concentrates, microcapsule suspension-water emulsions, or microcapsule suspension-suspoemulsions;

[0035] Furthermore, the formulation is in the form of a suspension, water-dispersible granules, microemulsion, aqueous emulsion, emulsifiable concentrate, wettable powder or dispersible oil suspension.

[0036] The present invention also discloses the use of the insecticide composition for preventing and controlling piercing-sucking mouthpart pests.

[0037] Furthermore, the pests are whiteflies and planthoppers;

[0038] Further, applying the above-mentioned insecticidal composition or its formulation to the pests to be controlled or the medium where they grow;

[0039] In order to obtain the desired insecticidal effect, the dosage of the pesticide composition varies depending on various factors, such as the crop to be protected, the type of pest, the degree of infection, climatic conditions, application site, application method, dosage form used, etc.

[0040] The beneficial effects of the present invention are as follows:

[0041] The insecticidal composition of the present invention has excellent control effects on various piercing-sucking mouthpart pests. The two active ingredients are compounded to have a significant synergistic effect on target pests within a suitable ratio, thereby reducing the development of pest resistance to the agent, reducing the amount of pesticide used, and reducing pollution to the environment. DETAILED DESCRIPTION

[0042] The specific embodiments of the present invention are described in detail below with reference to the examples, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0043] Preparation example:

[0044] Preparation Example 1: 35% cybenzoxasulfyl·spidoxamat water dispersible granules (3:2)

[0045] By weight percentage, cybenzoxasulfyl 21%, spidoxamat 14%, naphthalenesulfonate formaldehyde condensate 7%, lignin sulfonate 8%, sodium lauryl sulfate 3%, ammonium sulfate 10%, and starch makes up the balance;

[0046] Preparation method: According to the formula ratio of the embodiment, the active ingredient is added to the carrier, and a surfactant and other functional additives are added thereto, mixed, and after air flow grinding, 10-25% water is added, and then kneading, granulation, drying, and sieving are carried out to obtain a water-dispersible granule product; or the pulverized powder is sprayed with water in a boiling granulator, granulated, dried, and then sieved to obtain the product.

[0047] Preparation Example 2: 27% cybenzoxasulfyl·spiropidion water dispersible granules (8:1)

[0048] By weight percentage, cybenzoxasulfyl 24%, spiropidion 3%, sodium lignin sulfonate 10%, sodium polycarboxylate 8%, dispersant MF, sodium lauryl sulfate 3%, white sugar 5%, and kaolin makes up the balance;

[0049] Preparation method: Same as Preparation Example 1.

[0050] Preparation Example 3: 30% cybenzoxasulfyl·spiromesifen water dispersible granules (4:1)

[0051] By weight percentage, cybenzoxasulfyl 24%, spiromesifen 6%, sodium lignin sulfonate 10%, lakai powder BX 3%, polycarboxylic acid sodium salt 6%, white sugar 5%, and kaolin makes up the balance;

[0052] Preparation method: Same as Preparation Example 1.

[0053] Preparation Example 4: 24% cybenzoxasulfyl·spidoxamat wettable powder (5:1)

[0054] Calculated by weight percentage, the following ingredients include 20% cybenzoxasulfyl, 4% spidoxamat, 6% naphthalenesulfonate, 4% dispersant NNO, 2% sodium lauryl sulfate, 2% succinate sulfonate, 6% ammonium sulfate, and kaolin to make up the balance.

[0055] Preparation method: The active ingredients, dispersant, wetting agent and filler are mixed according to the formula ratio, stirred evenly in a mixer, crushed in a jet mill and mixed evenly again to prepare the wettable powder of the composition of the present invention.

[0056] Preparation Example 5: 39% cybenzoxasulfyl·spiropidion wettable powder (1:12)

[0057] Calculated by weight, the following ingredients include 3% cybenzoxasulfyl, 36% spiropidion, 2% sodium polycarboxylate, 10% sodium lignin sulfonate, 3% BX powder, 2% naphthalenesulfonate formaldehyde condensate, 5% white carbon black, and the balance is made up of kaolin.

[0058] Preparation method: same as Preparation Example 4.

[0059] Preparation Example 6: 36% cybenzoxasulfyl·spiromesifen wettable powder (8:1)

[0060] By weight percentage, cybenzoxasulfyl 32%, spiromesifen 4%, sodium lignin sulfonate 5%, sodium alkylnaphthalene sulfonate 5%, BX powder 2%, white carbon black 5%, and kaolin makes up the balance;

[0061] Preparation method: same as Preparation Example 4.

[0062] Preparation Example 7: 11% cybenzoxasulfyl·spidoxamat emulsifiable concentrate (1:10)

[0063] Calculated by weight, 1% cybenzoxasulfy, 10% spidoxamat, 8% fatty alcohol polyoxyethylene ether, 7% styrylphenol polyoxyethylene ether, 3% calcium dodecylbenzenesulfonate, 18% acetophenone, 10% N-methylpyrrolidone, 10% cyclohexanone, and the balance is made up of trimethylbenzene.

[0064] Preparation method: add the measured active ingredients, solvent and cosolvent into a mixing kettle and stir to dissolve them, then add emulsifier, make up the balance with the remaining solvent, stir evenly in a stirring kettle, and filter to obtain the desired emulsifiable concentrate of the present invention.

[0065] Preparation Example 8: 18% cybenzoxasulfyl·spiropidion emulsifiable concentrate (1:5)

[0066] Calculated by weight, the following ingredients are: 3% cybenzoxasulfyl, 15% spiropidion, 22% propylene glycol methyl ether, 12% styrylphenol polyoxyethylene ether, 3% calcium dodecylbenzenesulfonate, 15% DMF, 15% cyclohexanone, and the balance is methyl oleate.

[0067] Preparation method: Same as Preparation Example 7.

[0068] Preparation Example 9: 20% cybenzoxasulfyl·spiromesifen emulsifiable concentrate (1:1)

[0069] Calculated by weight, the following ingredients include 10% cybenzoxasulfyl, 10% spiromesifen, 18% N-methylpyrrolidone, 15% alkylaryl polyoxyethylene ether polyoxypropylene ether, 3% calcium dodecylbenzenesulfonate, 10% DMF, 10% cyclohexanone, and the balance is made up of methyl oleate.

[0070] Preparation method: Same as Preparation Example 7.

[0071] Preparation Example 10: 30% cybenzoxasulfyl·spidoxamat suspension (1:5)

[0072] Calculated by weight: cybenzoxasulfyl 5%, spidoxamat 25%, sodium lauryl sulfate 1%, sorbitan polyoxyethylene ether 2%, polyoxyethylene sorbitan monooleate 3%, styrylphenol polyoxyethylene ether phosphate 3%, sodium lignin sulfonate 1%, xanthan gum 0.25%, glycerol 5%, sodium benzoate 0.1%, silicone oil 0.5%, and deionized water to make up the balance.

[0073] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in a reactor in sequence, water is added and mixed evenly, and the suspension product is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0074] Preparation Example 11: 20% cybenzoxasulfyl·spiropidion suspension (3:1)

[0075] Calculated by weight: 15% cybenzoxasulfyl, 5% spiropidion, 2% glycerol fatty acid ester polyoxyethylene ether, 2% sodium alkyl polyoxyethylene ether sulfonate, 4% alkylphenol polyoxyethylene ether phosphate, 2% sodium polycarboxylate, 3% styrylphenol polyoxyethylene ether phosphate, 0.25% xanthan gum, 5% ethylene glycol, 0.2% sodium sorbate, 0.5% dimethyl silicone oil, and the balance is made up with deionized water.

[0076] Preparation method: Same as Preparation Example 10.

[0077] Preparation Example 12: 17% cybenzoxasulfyl·spiromesifen suspension (1:16)

[0078] By weight percentage, cybenzoxasulfyl 1%, spiromesifen 16%, castor oil polyoxyethylene ether 2%, naphthalenesulfonate formaldehyde condensate 1%, polyoxyethylene sorbitan monooleate 3%, phenylethylphenol polyoxyethylene polyoxypropylene ether 2%, xanthan gum 0.25%, magnesium aluminum silicate 1%, propylene glycol 5%, potassium benzoate 0.1%, silicone oil 0.5%, and deionized water to make up the balance;

[0079] Preparation method: Same as Preparation Example 10.

[0080] Indoor joint action test:

[0081] Example 1: Indoor activity assay of Bemisia tabaci

[0082] Test basis: The test refers to NY / T 1154.9-2008 "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides Part 9: Spray Method" and NY / T 1154.7-2006 "Guidelines for Indoor Bioassay Tests of Pesticides - Insecticides Part 7: Determination of Combined Action of Mixtures".

[0083] Test agents: cybenzoxasulfyl, spidoxamat, spiropidion, and spiromesifen technical.

[0084] The test target was Bemisia tabaci Gennadius, second-instar nymphs reared indoors and in a consistent physiological state.

[0085] Preparation of pharmaceuticals: Prepare the mother liquor of single doses separately, and design a reasonable ratio according to the mixing purpose and the activity of the pharmaceuticals. Each single dose and each group of mixed doses shall be prepared into the required series of mass concentrations according to the equal ratio method.

[0086] Preparation of Potter spray tower: Stabilize the spray pressure of the Potter spray tower at 1.47×10 5Pa, the spray head was cleaned twice with acetone and then twice with distilled water.

[0087] Chemical treatment: 20 test insects of consistent physiological state were selected using a brush and placed in a Petri dish. The dish was then placed on the bottom plate of a Potter spray tower and sprayed with a fixed volume of 1 mL. The insects were removed after the chemical settled for 1 minute and reared. Each treatment was replicated four times, with a treatment containing no chemical (including all organic solvents and emulsifiers) serving as a blank control.

[0088] Rearing and observation: The treated test insects were placed in a temperature of (25±1)℃, relative humidity of (70±5)%, and a photoperiod of L:D=(16:8)h for rearing and observation.

[0089] Data statistics and analysis: 48 h after treatment, the mortality of the test insects was checked and the total number of insects and the number of dead insects were recorded respectively.

[0090] Based on the survey data, calculate the adjusted mortality rate of each treatment using formulas (1) and (2), with the results rounded to two decimal places:

[0091]

[0092] Where:

[0093] P——mortality rate, in percentage (%);

[0094] K——indicates the number of dead insects, the unit is head;

[0095] N——represents the total number of insects processed, in heads.

[0096]

[0097] Where:

[0098] P1——adjusted mortality rate, in percentage (%);

[0099] P t ——Treatment mortality rate, expressed in percentage (%);

[0100] P0 - blank control mortality rate, in percentage (%).

[0101] If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction should be made according to formula (2); if the control mortality rate is greater than 20%, the test needs to be repeated.

[0102] Use DPS statistical analysis system to analyze and obtain the toxicity regression equation, LC 50 The activity of the test agent on the biological test material was evaluated by using the value and correlation coefficient.

[0103] The co-toxicity coefficient (CTC value) of the mixture is calculated according to formula (3), formula (4), and formula (5):

[0104]

[0105] Where:

[0106] ATI - measured toxicity index of mixture;

[0107] S——LC of standard pesticide 50 , the unit is milligrams per liter (mg / L);

[0108] M——LC of the mixture 50 , the unit is milligrams per liter (mg / L).

[0109] TTI=TI A ×P A +TI B ×P B ·······(4)

[0110] Where:

[0111] TTI – Theoretical Toxicity Index of Mixtures;

[0112] TI A ——Agent toxicity index;

[0113] P A ——The percentage of agent A in the mixture, in percentage (%);

[0114] TI B ——Toxicity index of agent B;

[0115] P B ——The percentage of agent B in the mixture, in percentage (%).

[0116]

[0117] Where:

[0118] CTC – Co-toxicity coefficient;

[0119] ATI - measured toxicity index of mixture;

[0120] TTI - Theoretical Toxicity Index of Mixture.

[0121] A co-toxicity coefficient (CTC) of 120 or higher indicates a synergistic effect; a co-toxicity coefficient (CTC) of 80 or lower indicates an antagonistic effect; and a co-toxicity coefficient (CTC) of 80 or lower indicates an additive effect.

[0122] The results of the indoor combined action test are shown in the table below:

[0123] Table 1 Results of indoor bioactivity test of cybenzoxasulfyl and Spidoxamat complex against Bemisia tabaci

[0124]

[0125] Indoor toxicity results (Table 1) showed that combining cybenzoxasulfyl with Spidoxatam exhibited excellent control efficacy against whiteflies within an appropriate mass ratio range. The mass ratios of cybenzoxasulfyl to Spidoxatam ranged from 35:1 to 1:25, with a co-toxicity coefficient greater than 120, exhibiting a synergistic effect against whiteflies. The mass ratios of cybenzoxasulfyl to Spidoxatam ranged from 25:1 to 1:15, with a co-toxicity coefficient greater than 140, exhibiting a significant synergistic effect. The mass ratios of cybenzoxasulfyl to Spidoxatam ranged from 15:1 to 1:10, with a co-toxicity coefficient greater than 150, exhibiting a significant synergistic effect.

[0126] Table 2 Results of indoor bioactivity test of cybenzoxasulfyl and spiropidion complexes against Bemisia tabaci

[0127]

[0128]

[0129] Laboratory toxicity tests showed that combining cybenzoxasulfyl with spiropidion exhibited excellent control efficacy against Bemisia tabaci within an appropriate mass ratio range. The mass ratios of cybenzoxasulfyl to spiropidion ranged from 30:1 to 1:24, with a co-toxicity coefficient exceeding 120, exhibiting a synergistic effect against Bemisia tabaci. The mass ratios of cybenzoxasulfyl to spiropidion ranged from 25:1 to 1:12, with a co-toxicity coefficient exceeding 140, demonstrating a significant synergistic effect. The mass ratios of cybenzoxasulfyl to spiropidion ranged from 15:1 to 1:5, with a co-toxicity coefficient exceeding 150, demonstrating a significant synergistic effect.

[0130] Table 3 Results of indoor bioactivity test of cybenzoxasulfyl and spiromesifen against Bemisia tabaci

[0131]

[0132] Indoor toxicity tests showed that combining cybenzoxasulfyl with spiromesifen exhibited excellent control efficacy against Bemisia tabaci within an appropriate mass ratio range. The mass ratios of cybenzoxasulfyl to spiromesifen ranged from 20:1 to 1:28, with a co-toxicity coefficient exceeding 120, exhibiting a synergistic effect against Bemisia tabaci. The mass ratios of cybenzoxasulfyl to spiromesifen ranged from 8:1 to 1:8, with a co-toxicity coefficient exceeding 140, demonstrating a significant synergistic effect. The mass ratios of cybenzoxasulfyl to spiromesifen ranged from 4:1 to 1:4, with a co-toxicity coefficient exceeding 150, demonstrating a significant synergistic effect.

[0133] Field efficacy test:

[0134] Example 2: Field efficacy test on Bemisia tabaci

[0135] Test basis: The test refers to NY / T 1464.43-2012 "Guidelines for Field Efficacy Tests of Pesticides Part 43: Insecticides for Control of Vegetable Whiteflies".

[0136] Experimental location: The experiment was conducted at the tomato planting base in Wangyuan Village, Chengfu Town, Qiaocheng District, Bozhou City, Anhui Province. The experimental site has flat terrain and medium fertility. The fertilizer and water management is relatively uniform and consistent, which is in line with local scientific agricultural practices (GAP).

[0137] Test crop: Tomato.

[0138] Test target: Bemisia tabaci. During the test, tomatoes were in the young fruit stage.

[0139] Experimental design: The experimental plot area is 30m 2 , 4 replicates, randomized block arrangement.

[0140] Application Method and Timing: The trial was conducted on September 3, 2023, using a Singapore Linong 16L high-pressure manual sprayer for conventional spraying. A blank control was sprayed with an equal amount of water. The pesticide was thoroughly diluted with a small amount of water, then added with enough water to achieve the desired dilution factor. The spray was evenly applied to both sides of the leaves. The base insect population was assessed before application, and the number of live insects was counted 1, 3, and 7 days after application.

[0141] Survey method: 20 crops were marked in each plot, and all the adults were surveyed in the morning when the adults were inactive. The survey was conducted before 9:00 am, focusing on the back of the leaves. The number of live insects was surveyed and recorded while trying not to disturb the insects.

[0142] Calculation method of drug efficacy:

[0143]

[0144] Field observations during the trial showed normal growth of tomatoes in all treatments, consistent with the blank control. None of the test agents exhibited any adverse effects, such as growth stunting, chlorosis, or deformities. No effects were observed on other target organisms compared to the blank control.

[0145] The field efficacy test is shown in the table below:

[0146] Table 4 Results of field efficacy tests on Bemisia tabaci

[0147]

[0148] The test results, shown in Table 4, show that compounding cybenzoxasulfyl with any of pidoxamat, spiropidion, and spiromesifen in appropriate mass ratios demonstrated excellent control efficacy against Bemisia tabaci. These test results demonstrate that the compounded insecticidal compositions of the present invention significantly outperformed the single-dose control group in terms of control efficacy, exhibiting rapid effectiveness and a long-lasting effect. Furthermore, field trials revealed no phytotoxicity or other adverse effects on tomatoes, nor on beneficial organisms, observed with any of the treatments.

[0149] Although the present application describes specific embodiments in detail by way of example, the disclosure of the present application may adopt various modifications and alternative forms. However, it should be understood that the disclosure of the present application is not limited to the specific forms disclosed. On the contrary, the disclosure of the present application covers all modifications, equivalents and alternative forms within the scope of the disclosure of the present application, and the scope of the present application is limited by the appended claims and their legal equivalents.

Claims

1. An insecticidal composition containing cybenzoxasulfyl, characterized in that: The active ingredients of the insecticide composition include active ingredient A and active ingredient B, wherein the active ingredient A is cybenzoxasulfyl, and the active ingredient B is any one of spidoxamat, spiropidion or spiromesifen; The mass ratio of cybenzoxasulfyl to spidoxamat is 35:1 to 1:25; The mass ratio of cybenzoxasulfyl to spiropidion is 30:1 to 1:24; The mass ratio of cybenzoxasulfyl to spiromesifen is 20:1 to 1:

28.

2. The insecticidal composition according to claim 1, characterized in that The mass ratio of cybenzoxasulfyl to spidoxamat is 25:1 to 1:15; The mass ratio of cybenzoxasulfyl to spiropidion is 25:1 to 1:12; The mass ratio of cybenzoxasulfyl to spiromesifen is 8:1-1:

16.

3. The insecticidal composition according to claim 2, characterized in that The mass ratio of cybenzoxasulfyl to spidoxamat is 15:1 to 1:10; The mass ratio of cybenzoxasulfyl to spiropidion is 15:1 to 1:5; The mass ratio of cybenzoxasulfyl to spiromesifen is 8:1 to 1:

8.

4. The insecticidal composition according to claim 1, characterized in that The total weight of the insecticide composition is 100 wt %, and the mass ratio of the active ingredient A to the active ingredient B accounts for 1% to 70% of the total weight of the insecticide composition.

5. The insecticidal composition according to claim 4, characterized in that The total weight of the insecticide composition is 100 wt %, and the mass ratio of the active ingredient A to the active ingredient B accounts for 2% to 60% of the total weight of the insecticide composition.

6. The insecticidal composition according to claim 1, characterized in that The insecticide composition is prepared into a formulation, which is a suspension, water-dispersible granules, microemulsion, emulsion in water, emulsifiable concentrate, wettable powder or dispersible oil suspension.

7. Use of the insecticidal composition according to any one of claims 1 to 6 for controlling piercing-sucking pests.

8. The use according to claim 7, characterized in that The pests are whiteflies and plant hoppers.

9. The use according to claim 7, characterized in that The insecticidal composition or formulation according to any one of claims 1 to 6 is applied to the pests to be controlled or the medium in which they grow.

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